Year |
Citation |
Score |
2020 |
Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. CHARACTERIZATION OF DIFFERENTIAL TISSUE ABUNDANCE OF MAJOR NON-CYP ENZYMES IN HUMAN. Molecular Pharmaceutics. PMID 32955894 DOI: 10.1021/Acs.Molpharmaceut.0C00559 |
0.323 |
|
2016 |
Le H, Fan PW, Wong S, Ma S, Driscoll JP, Hop CE, Cyrus Khojasteh S. Elucidating the Mechanism of Tofacitinib Oxidative Decyanation. Drug Metabolism Letters. PMID 27117606 DOI: 10.2174/1872312810666160427104954 |
0.36 |
|
2011 |
Zhang C, Kenny JR, Le H, Deese A, Ford KA, Lightning LK, Fan PW, Driscoll JP, Halladay JS, Hop CE, Khojasteh SC. Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition. Chemical Research in Toxicology. 24: 1668-77. PMID 21905702 DOI: 10.1021/Tx2002228 |
0.425 |
|
2010 |
Wong SG, Fan PW, Subramanian R, Tonn GR, Henne KR, Johnson MG, Tadano Lohr M, Wong BK. Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 841-50. PMID 20100816 DOI: 10.1124/Dmd.109.031344 |
0.333 |
|
2001 |
Fan PW, Bolton JL. Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 891-6. PMID 11353759 |
0.607 |
|
2000 |
Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. Chemical Research in Toxicology. 13: 53-62. PMID 10649967 DOI: 10.1021/Tx990145N |
0.617 |
|
2000 |
Fan PW, Zhang F, Bolton JL. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides. Chemical Research in Toxicology. 13: 45-52. PMID 10649966 DOI: 10.1021/Tx990144V |
0.65 |
|
1999 |
Nikolic D, Fan PW, Bolton JL, van Breemen RB. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry. Combinatorial Chemistry & High Throughput Screening. 2: 165-75. PMID 10420970 |
0.517 |
|
1998 |
Sanchez C, Shibutani S, Dasaradhi L, Bolton JL, Fan PW, McClelland RA. Lifetime and reactivity of an ultimate tamoxifen carcinogen: The tamoxifen carbocation [1] Journal of the American Chemical Society. 120: 13513-13514. DOI: 10.1021/Ja982701Q |
0.615 |
|
1997 |
Ramakrishna KV, Fan PW, Boyer CS, Dalvie D, Bolton JL. Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen. Chemical Research in Toxicology. 10: 887-94. PMID 9282838 DOI: 10.1021/tx970060r |
0.532 |
|
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