| Year |
Citation |
Score |
| 2016 |
O'Brien CJ, Blanco MA, Costanzo JA, Enterline M, Fernandez EJ, Robinson AS, Roberts CJ. Modulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutations. Protein Engineering, Design & Selection : Peds. PMID 27160179 DOI: 10.1093/Protein/Gzw010 |
0.395 |
|
| 2014 |
Gospodarek AM, Sun W, O'Connell JP, Fernandez EJ. Structures of multidomain proteins adsorbed on hydrophobic interaction chromatography surfaces. Journal of Chromatography. A. 1371: 204-19. PMID 25456599 DOI: 10.1016/J.Chroma.2014.10.080 |
0.389 |
|
| 2014 |
Gospodarek AM, Hiser DE, O'Connell JP, Fernandez EJ. Unfolding of a model protein on ion exchange and mixed mode chromatography surfaces. Journal of Chromatography. A. 1355: 238-52. PMID 24997510 DOI: 10.1016/J.Chroma.2014.06.024 |
0.397 |
|
| 2014 |
Costanzo JA, O'Brien CJ, Tiller K, Tamargo E, Robinson AS, Roberts CJ, Fernandez EJ. Conformational stability as a design target to control protein aggregation. Protein Engineering, Design & Selection : Peds. 27: 157-67. PMID 24722670 DOI: 10.1093/Protein/Gzu008 |
0.4 |
|
| 2014 |
Weiss WF, Zhang A, Ivanova MI, Sahin E, Jordan JL, Fernandez EJ, Roberts CJ. Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation. Biophysical Chemistry. 185: 79-87. PMID 24374388 DOI: 10.1016/J.Bpc.2013.11.005 |
0.709 |
|
| 2014 |
Gregoire S, Zhang S, Costanzo J, Wilson K, Fernandez EJ, Kwon I. Cis-suppression to arrest protein aggregation in mammalian cells. Biotechnology and Bioengineering. 111: 462-74. PMID 24114411 DOI: 10.1002/Bit.25119 |
0.37 |
|
| 2013 |
Kim N, Remmele RL, Liu D, Razinkov VI, Fernandez EJ, Roberts CJ. Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration. Biophysical Chemistry. 172: 26-36. PMID 23334430 DOI: 10.1016/J.Bpc.2012.12.004 |
0.378 |
|
| 2012 |
Brummitt RK, Andrews JM, Jordan JL, Fernandez EJ, Roberts CJ. Thermodynamics of amyloid dissociation provide insights into aggregate stability regimes. Biophysical Chemistry. 168: 10-8. PMID 22750559 DOI: 10.1016/J.Bpc.2012.06.001 |
0.586 |
|
| 2012 |
Zhang A, Singh SK, Shirts MR, Kumar S, Fernandez EJ. Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharmaceutical Research. 29: 236-50. PMID 21805212 DOI: 10.1007/S11095-011-0538-Y |
0.609 |
|
| 2011 |
Wong HE, Qi W, Choi HM, Fernandez EJ, Kwon I. A safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregates. Acs Chemical Neuroscience. 2: 645-57. PMID 22860159 DOI: 10.1021/Cn200056G |
0.318 |
|
| 2011 |
Zhang A, Qi W, Singh SK, Fernandez EJ. A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS). Pharmaceutical Research. 28: 1179-93. PMID 21301933 DOI: 10.1007/S11095-011-0383-Z |
0.602 |
|
| 2011 |
Sahin E, Jordan JL, Spatara ML, Naranjo A, Costanzo JA, Weiss WF, Robinson AS, Fernandez EJ, Roberts CJ. Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity. Biochemistry. 50: 628-39. PMID 21184609 DOI: 10.1021/Bi100978R |
0.6 |
|
| 2011 |
Gospodarek AM, Smatlak ME, O'Connell JP, Fernandez EJ. Protein stability and structure in HIC: hydrogen exchange experiments and COREX calculations. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 286-95. PMID 21117672 DOI: 10.1021/La103793R |
0.412 |
|
| 2010 |
Zhang A, Jordan JL, Ivanova MI, Weiss WF, Roberts CJ, Fernandez EJ. Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology. Biochemistry. 49: 10553-64. PMID 21067192 DOI: 10.1021/Bi1014216 |
0.699 |
|
| 2010 |
Deitcher RW, O'Connell JP, Fernandez EJ. Changes in solvent exposure reveal the kinetics and equilibria of adsorbed protein unfolding in hydrophobic interaction chromatography Journal of Chromatography A. 1217: 5571-5583. PMID 20630532 DOI: 10.1016/J.Chroma.2010.06.051 |
0.422 |
|
| 2010 |
Deitcher RW, Rome JE, Gildea PA, O'Connell JP, Fernandez EJ. A new thermodynamic model describes the effects of ligand density and type, salt concentration and protein species in hydrophobic interaction chromatography Journal of Chromatography A. 1217: 199-208. PMID 19695574 DOI: 10.1016/J.Chroma.2009.07.068 |
0.31 |
|
| 2009 |
Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS. The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. Protein Science : a Publication of the Protein Society. 18: 2067-79. PMID 19670212 DOI: 10.1002/Pro.219 |
0.553 |
|
| 2009 |
Qi W, Zhang A, Good TA, Fernandez EJ. Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. Biochemistry. 48: 8908-19. PMID 19637920 DOI: 10.1021/Bi9006397 |
0.568 |
|
| 2009 |
Jordan JL, Arndt JW, Hanf K, Li G, Hall J, Demarest S, Huang F, Wu X, Miller B, Glaser S, Fernandez EJ, Wang D, Lugovskoy A. Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules. Proteins. 77: 832-41. PMID 19626705 DOI: 10.1002/Prot.22502 |
0.518 |
|
| 2009 |
Ramos I, Fabris D, Qi W, Fernandez EJ, Good TA. Kinetic study of beta-amyloid residue accessibility using reductive alkylation and mass spectrometry. Biotechnology and Bioengineering. 104: 181-92. PMID 19418563 DOI: 10.1002/Bit.22367 |
0.355 |
|
| 2009 |
Salay LC, Qi W, Keshet B, Tamm LK, Fernandez EJ. Membrane interactions of a self-assembling model peptide that mimics the self-association, structure and toxicity of Abeta(1-40). Biochimica Et Biophysica Acta. 1788: 1714-21. PMID 19393615 DOI: 10.1016/J.Bbamem.2009.04.010 |
0.314 |
|
| 2009 |
Zhang A, Qi W, Good TA, Fernandez EJ. Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange. Biophysical Journal. 96: 1091-104. PMID 19186145 DOI: 10.1016/J.Bpj.2008.10.022 |
0.605 |
|
| 2009 |
Deitcher RW, Xiao Y, O'Connell JP, Fernandez EJ. Protein instability during HIC: Evidence of unfolding reversibility, and apparent adsorption strength of disulfide bond-reduced α-lactalbumin variants Biotechnology and Bioengineering. 102: 1416-1427. PMID 19152385 DOI: 10.1002/Bit.22171 |
0.394 |
|
| 2008 |
Jordan JL, Fernandez EJ. QCM-D sensitivity to protein adsorption reversibility. Biotechnology and Bioengineering. 101: 837-42. PMID 18623227 DOI: 10.1002/Bit.21977 |
0.578 |
|
| 2008 |
Keener RN, Fernandez EJ, Maneval JE, Hart RA. Advancement in the modeling of pressure-flow for the guidance of development and scale-up of commercial-scale biopharmaceutical chromatography. Journal of Chromatography. A. 1190: 127-40. PMID 18374935 DOI: 10.1016/J.Chroma.2008.02.113 |
0.753 |
|
| 2008 |
Qi W, Zhang A, Patel D, Lee S, Harrington JL, Zhao L, Schaefer D, Good TA, Fernandez EJ. Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-40) fibrillogenesis. Biotechnology and Bioengineering. 100: 1214-27. PMID 18351682 DOI: 10.1002/Bit.21846 |
0.63 |
|
| 2007 |
Xiao Y, Rathore A, O'Connell JP, Fernandez EJ. Generalizing a two-conformation model for describing salt and temperature effects on protein retention and stability in hydrophobic interaction chromatography. Journal of Chromatography. A. 1157: 197-206. PMID 17524412 DOI: 10.1016/J.Chroma.2007.05.009 |
0.398 |
|
| 2007 |
Lee S, Fernandez EJ, Good TA. Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway. Protein Science : a Publication of the Protein Society. 16: 723-32. PMID 17327396 DOI: 10.1110/Ps.062514807 |
0.347 |
|
| 2007 |
Xiao Y, Jones TT, Laurent AH, O'Connell JP, Przybycien TM, Fernandez EJ. Protein instability during HIC: hydrogen exchange labeling analysis and a framework for describing mobile and stationary phase effects. Biotechnology and Bioengineering. 96: 80-93. PMID 16952152 DOI: 10.1002/Bit.21186 |
0.421 |
|
| 2006 |
Fogle JL, O'Connell JP, Fernandez EJ. Loading, stationary phase, and salt effects during hydrophobic interaction chromatography: alpha-lactalbumin is stabilized at high loadings. Journal of Chromatography. A. 1121: 209-18. PMID 16690064 DOI: 10.1016/J.Chroma.2006.04.015 |
0.756 |
|
| 2006 |
Xiao Y, Freed AS, Jones TT, Makrodimitris K, O'Connell JP, Fernandez EJ. Protein instability during HIC: describing the effects of mobile phase conditions on instability and chromatographic retention. Biotechnology and Bioengineering. 93: 1177-89. PMID 16444741 DOI: 10.1002/Bit.20826 |
0.392 |
|
| 2006 |
Fernandez EJ, Tobler SA. Elucidating structure, stability, and conformational distributions during protein aggregation with hydrogen exchange and mass spectrometry Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability. 81-98. DOI: 10.1007/978-0-387-36063-8_4 |
0.792 |
|
| 2006 |
Fogle JL, Fernandez EJ. Amide hydrogen-deuterium exchange: A fast tool for screening protein stabilities in chromatography Lcgc North America. 24: 158-168. |
0.781 |
|
| 2006 |
Fogle JL, Fernandez EJ. Amide hydrogen-deuterium exchange: A fast tool for screening protein stabilities in chromatography Lcgc North America. 24: 158-168. |
0.337 |
|
| 2005 |
Makrodimitris K, Fernandez EJ, Woolf TB, O'Connell JP. Mesoscopic simulation of adsorption of peptides in a hydrophobic chromatography system. Analytical Chemistry. 77: 1243-52. PMID 15732903 DOI: 10.1021/Ac048812R |
0.321 |
|
| 2004 |
Keener RN, Maneval JE, Fernandez EJ. Toward a robust model of packing and scale-up for chromatographic beds. 2. Flow packing. Biotechnology Progress. 20: 1159-68. PMID 15296443 DOI: 10.1021/Bp0342809 |
0.758 |
|
| 2004 |
Keener RN, Maneval JE, Fernandez EJ. Toward a robust model of packing and scale-up for chromatographic beds. 1. Mechanical compression. Biotechnology Progress. 20: 1146-58. PMID 15296442 DOI: 10.1021/Bp034279+ |
0.759 |
|
| 2004 |
Jones TT, Fernandez EJ. Hydrophobic interaction chromatography selectivity changes among three stable proteins: conformation does not play a major role. Biotechnology and Bioengineering. 87: 388-99. PMID 15281113 DOI: 10.1002/Bit.20123 |
0.416 |
|
| 2004 |
Tobler SA, Holmes BW, Cromwell ME, Fernandez EJ. Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange. Journal of Pharmaceutical Sciences. 93: 1605-17. PMID 15124217 DOI: 10.1002/Jps.10589 |
0.78 |
|
| 2003 |
Sokol JM, Holmes BW, O'Connell JP, Fernandez EJ. Aprotinin conformational distributions during reversed-phase liquid chromatography. Analysis by hydrogen-exchange mass spectrometry. Journal of Chromatography. A. 1007: 55-66. PMID 12924551 DOI: 10.1016/S0021-9673(03)00979-8 |
0.404 |
|
| 2003 |
Wang SS, Tobler SA, Good TA, Fernandez EJ. Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure. Biochemistry. 42: 9507-14. PMID 12899638 DOI: 10.1021/Bi0342766 |
0.765 |
|
| 2003 |
Tibbs Jones T, Fernandez EJ. Alpha-lactalbumin tertiary structure changes on hydrophobic interaction chromatography surfaces. Journal of Colloid and Interface Science. 259: 27-35. PMID 12651130 DOI: 10.1016/S0021-9797(02)00180-7 |
0.334 |
|
| 2002 |
Keener RN, Maneval JE, Ostergren KC, Fernandez EJ. Mechanical deformation of compressible chromatographic columns. Biotechnology Progress. 18: 587-96. PMID 12052077 DOI: 10.1021/Bp020051V |
0.761 |
|
| 2002 |
Tobler SA, Fernandez EJ. Structural features of interferon-gamma aggregation revealed by hydrogen exchange. Protein Science : a Publication of the Protein Society. 11: 1340-52. PMID 12021433 DOI: 10.1110/Ps.3770102 |
0.787 |
|
| 2001 |
McNay JL, O'Connell JP, Fernandez EJ. Protein unfolding during reversed-phase chromatography: II. Role of salt type and ionic strength. Biotechnology and Bioengineering. 76: 233-40. PMID 11668459 DOI: 10.1002/Bit.10016 |
0.638 |
|
| 2001 |
McNay JL, Fernandez EJ. Protein unfolding during reversed-phase chromatography: I. Effect of surface properties and duration of adsorption. Biotechnology and Bioengineering. 76: 224-32. PMID 11668458 DOI: 10.1002/Bit.10015 |
0.63 |
|
| 2001 |
Chang ST, Tobler SA, Fernandez EJ. Unfolding and conformational distributions during protein precipitation. Biotechnology Progress. 17: 583-5. PMID 11386884 DOI: 10.1021/Bp010025H |
0.79 |
|
| 2000 |
Tobler SA, Sherman NE, Fernandez EJ. Tracking lysozyme unfolding during salt-induced precipitation with hydrogen exchange and mass spectrometry. Biotechnology and Bioengineering. 71: 194-207. PMID 11291029 DOI: 10.1002/1097-0290(2000)71:3<194::Aid-Bit1009>3.0.Co;2-Q |
0.784 |
|
| 1999 |
McNay JL, Fernandez EJ. How does a protein unfold on a reversed-phase liquid chromatography surface? Journal of Chromatography A. 849: 135-148. DOI: 10.1016/S0021-9673(99)00546-4 |
0.615 |
|
| 1998 |
Chang ST, Fernandez EJ. Probing residue-level unfolding during lysozyme precipitation Biotechnology and Bioengineering. 59: 144-155. PMID 10099325 DOI: 10.1002/(Sici)1097-0290(19980720)59:2<144::Aid-Bit2>3.0.Co;2-H |
0.373 |
|
| 1998 |
Mancuso A, Sharfstein ST, Fernandez EJ, Clark DS, Blanch HW. Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma: an in vivo 13C nuclear magnetic resonance study. Biotechnology and Bioengineering. 57: 172-86. PMID 10099192 DOI: 10.1002/(Sici)1097-0290(19980120)57:2<172::Aid-Bit6>3.0.Co;2-K |
0.718 |
|
| 1997 |
Mitchell NS, Hagel L, Fernandez EJ. In situ analysis of protein chromotography and column efficiency using magnetic resonance imaging Journal of Chromatography A. 779: 73-89. PMID 9335119 DOI: 10.1016/S0021-9673(97)00457-3 |
0.354 |
|
| 1997 |
Dickson ML, Norton TT, Fernandez EJ. Chemical Imaging of Multicomponent Viscous Fingering in Chromatography Aiche Journal. 43: 409-418. DOI: 10.1002/Aic.690430214 |
0.721 |
|
| 1996 |
Tucker Norton T, Fernandez EJ. Viscous fingering in size exclusion chromatography: Insights from numerical simulation Industrial and Engineering Chemistry Research. 35: 2460-2468. DOI: 10.1021/Ie950777E |
0.343 |
|
| 1996 |
Fernandez EJ, Norton TT, Jung WC, Tsavalas JG. A column design for reducing viscous fingering in size exclusion chromatography Biotechnology Progress. 12: 480-487. DOI: 10.1021/Bp960031R |
0.336 |
|
| 1995 |
Fernandez EJ, Grotegut CA, Braun GW, Kirschner KJ, Staudaher JR, Dickson ML, Fernandez VL. The effects of permeability heterogeneity on miscible viscous fingering: A three-dimensional magnetic resonance imaging analysis Physics of Fluids. 7: 468-477. DOI: 10.1063/1.868645 |
0.728 |
|
| 1990 |
Fernandez EJ, Mancuso A, Murphy MK, Blanch HW, Clark DS. Nuclear magnetic resonance methods for observing the intracellular environment of mammalian cells. Annals of the New York Academy of Sciences. 589: 458-75. PMID 2357030 DOI: 10.1111/J.1749-6632.1990.Tb24264.X |
0.544 |
|
| 1990 |
Mancuso A, Fernandez EJ, Blanch HW, Clark DS. A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors. Bio/Technology (Nature Publishing Company). 8: 1282-5. PMID 1366962 DOI: 10.1038/nbt1290-1282 |
0.555 |
|
| 1989 |
Murphy MK, Fernandez EJ, Clark DS. A comparison of three radiofrequency coils for NMR studies of conductive samples Magnetic Resonance in Medicine. 12: 382-389. PMID 2628686 DOI: 10.1002/Mrm.1910120311 |
0.387 |
|
| 1987 |
Clark DS, Skerker PS, Fernandez EJ, Jagoda RB. SPECTROSCOPIC STUDIES OF STRUCTURE-FUNCTION RELATIONSHIPS IN FREE AND IMMOBILIZED ALCOHOL DEHYDROGENASE Annals of the New York Academy of Sciences. 506: 117-128. PMID 2829683 DOI: 10.1111/j.1749-6632.1987.tb23814.x |
0.376 |
|
| 1987 |
Fernandez EJ, Clark DS. N.m.r. spectroscopy: A non-invasive tool for studying intracellular processes Enzyme and Microbial Technology. 9: 259-271. DOI: 10.1016/0141-0229(87)90001-9 |
0.375 |
|
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