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Kirk A. Staschke, Ph.D. - Publications

Affiliations: 
2010 Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Molecular Biology
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Levy JL, Mirek ET, Rodriguez EM, Zalma B, Burns J, Jonsson WO, Sampath H, Staschke KA, Wek RC, Anthony TG. GCN2 is required to maintain core body temperature in mice during acute cold. American Journal of Physiology. Endocrinology and Metabolism. PMID 37792040 DOI: 10.1152/ajpendo.00181.2023  0.6
2023 Stokes ME, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, Shen L, Gasparek J, Betzenhauser M, Taylor SJ, Staschke KA, Rigby AC, Mulvihill MJ, Bose N, Lightcap ES, et al. PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 37733811 DOI: 10.1158/1078-0432.CCR-23-1182  0.304
2023 Mijit M, Boner M, Cordova RA, Gampala S, Kpenu E, Klunk AJ, Zhang C, Kelley MR, Staschke KA, Fishel ML. Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment. Frontiers in Medicine. 10: 1146115. PMID 37181357 DOI: 10.3389/fmed.2023.1146115  0.379
2023 Wek RC, Anthony TG, Staschke KA. Surviving and adapting to stress: Translational control and the integrated stress response. Antioxidants & Redox Signaling. PMID 36943285 DOI: 10.1089/ars.2022.0123  0.661
2023 Carlson KR, Georgiadis MM, Tameire F, Staschke KA, Wek RC. Activation of Gcn2 by small molecules designed to be inhibitors. The Journal of Biological Chemistry. 299: 104595. PMID 36898579 DOI: 10.1016/j.jbc.2023.104595  0.663
2022 Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Davé U, Kapur R, Batra S, Zhang C, Zhou J, Fan J, et al. Asparagine bioavailability regulates the translation of MYC oncogene. Oncogene. PMID 36182969 DOI: 10.1038/s41388-022-02474-9  0.592
2022 Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, ... ... Staschke KA, et al. GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis. Elife. 11. PMID 36107759 DOI: 10.7554/eLife.81083  0.604
2019 Staschke KA, Wek RC. Adapting to cell stress from inside and out. Nature Cell Biology. 21: 799-800. PMID 31263267 DOI: 10.1038/S41556-019-0354-X  0.607
2018 Augusto L, Martynowicz J, Staschke KA, Wek RC, Sullivan WJ. Effects of PERK eIF2α kinase inhibitor against . Antimicrobial Agents and Chemotherapy. PMID 30181373 DOI: 10.1128/Aac.01442-18  0.619
2018 Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A, Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE. Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells. Cell Death & Disease. 9: 254. PMID 29449538 DOI: 10.1038/S41419-018-0326-2  0.406
2018 Schaer D, Beckmann R, Dempsey J, Huber L, Forest A, Amaladas N, Wang YC, Rasmussen E, Chin D, Li Y, Capen A, Deroose M, Carpenito C, Gong X, Staschke K, et al. Abstract 4569: The CDK4/6 inhibitor abemaciclib synergizes with PD-L1 blockade to induce an immune inflamed tumor microenvironment through T cell and tumor cell intrinsic effects Cancer Research. 78: 4569-4569. DOI: 10.1158/1538-7445.Am2018-4569  0.303
2016 Pytel D, Gao Y, Mackiewicz K, Katlinskaya YV, Staschke KA, Paredes MC, Yoshida A, Qie S, Zhang G, Chajewski OS, Wu L, Majsterek I, Herlyn M, Fuchs SY, Diehl JA. PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. Plos Genetics. 12: e1006518. PMID 27977682 DOI: 10.1371/Journal.Pgen.1006518  0.373
2016 Sandoval MV, Fluegen G, Staschke KA, Calvo-Vidal V, Aguirre-Ghiso JA. Abstract A45: PERK-Inhibition as a possible therapy for hypoxia-induced solitary dormant tumor cells Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A45  0.356
2016 Calvo V, Staschke KA, Paredes MCG, Avivar-Valderas A, Cheung J, Wild R, Rigby AC, Farias EF, Aguirre-Ghiso J. Abstract A38: A PERK inhibitor that blocks HER2-driven tumorigenesis and suppresses metastasis by targeting single disseminated tumor cells Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A38  0.361
2015 Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE. mTORC2 balances Akt activation and eIF2alpha serine 51 phosphorylation to promote survival under stress. Molecular Cancer Research : McR. PMID 26130148 DOI: 10.1158/1541-7786.Mcr-15-0184-T  0.512
2014 Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, et al. Identification of druggable cancer driver genes amplified across TCGA datasets. Plos One. 9: e98293. PMID 24874471 DOI: 10.1371/Journal.Pone.0098293  0.338
2011 Kim TW, Febbraio M, Robinet P, Dugar B, Greene D, Cerny A, Latz E, Gilmour R, Staschke K, Chisolm G, Fox PL, DiCorleto PE, Smith JD, Li X. The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis. Journal of Immunology (Baltimore, Md. : 1950). 186: 2871-80. PMID 21278342 DOI: 10.4049/Jimmunol.1002242  0.337
2010 Wek RC, Staschke KA. How do tumours adapt to nutrient stress? The Embo Journal. 29: 1946-7. PMID 20551969 DOI: 10.1038/Emboj.2010.110  0.618
2010 Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, Edenberg HJ, Wek RC. Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. The Journal of Biological Chemistry. 285: 16893-911. PMID 20233714 DOI: 10.1074/Jbc.M110.121947  0.68
2008 Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X. Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NFκB activation Journal of Biological Chemistry. 283: 14654-14664. PMID 18326498 DOI: 10.1074/Jbc.M706931200  0.301
2008 Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA, Wek RC. Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. The Journal of Biological Chemistry. 283: 7064-73. PMID 18195013 DOI: 10.1074/Jbc.M708530200  0.716
2008 Rekhter M, Staschke K, Estridge T, Rutherford P, Jackson N, Gifford-Moore D, Foxworthy P, Reidy C, Huang XD, Kalbfleisch M, Hui K, Kuo MS, Gilmour R, Vlahos CJ. Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation. Biochemical and Biophysical Research Communications. 367: 642-8. PMID 18190779 DOI: 10.1016/J.Bbrc.2007.12.186  0.329
2007 Sklan EH, Staschke K, Oakes TM, Elazar M, Winters M, Aroeti B, Danieli T, Glenn JS. A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. Journal of Virology. 81: 11096-105. PMID 17686842 DOI: 10.1128/Jvi.01249-07  0.307
2007 Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH, Vandenburg Y, Xiao H, Qian W, Hamilton T, Min B, Sen G, Gilmour R, Li X. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. The Journal of Experimental Medicine. 204: 1025-36. PMID 17470642 DOI: 10.1084/Jem.20061825  0.355
2007 Huang Y, Staschke K, De Francesco R, Tan SL. Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication? Virology. 364: 1-9. PMID 17400273 DOI: 10.1016/J.Virol.2007.01.042  0.383
2004 Narasimhan J, Staschke KA, Wek RC. Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. The Journal of Biological Chemistry. 279: 22820-32. PMID 15010461 DOI: 10.1074/Jbc.M402228200  0.665
2001 Vattem KM, Staschke KA, Wek RC. Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). European Journal of Biochemistry / Febs. 268: 3674-84. PMID 11432733 DOI: 10.1046/J.1432-1327.2001.02273.X  0.635
2001 Vattem KM, Staschke KA, Zhu S, Wek RC. Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). European Journal of Biochemistry / Febs. 268: 1143-53. PMID 11179981 DOI: 10.1046/J.1432-1327.2001.01979.X  0.638
1998 Staschke KA, Hatch SD, Tang JC, Hornback WJ, Munroe JE, Colacino JM, Muesing MA. Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid Virology. 248: 264-274. PMID 9721235 DOI: 10.1006/Viro.1998.9273  0.3
1994 Staschke KA, Colacino JM, Mabry TE, Jones CD. The in vitro anti-hepatitis B virus activity of FIAU [1-(2′-deoxy-2′-fluoro-1-β-d-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell Antiviral Research. 23: 45-61. PMID 8141592 DOI: 10.1016/0166-3542(94)90032-9  0.301
1994 Staschke KA, Colacino JM. Priming of duck hepatitis B virus reverse transcription in vitro: Premature termination of primer DNA induced by the 5′-triphosphate of fialuridine Journal of Virology. 68: 8265-8269. PMID 7525986 DOI: 10.1128/Jvi.68.12.8265-8269.1994  0.318
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