Mitchell F. Denning - Publications

Affiliations: 
Molecular Biology Loyola University Chicago, Chicago, IL, United States 
Area:
Molecular Biology, Cell Biology, Oncology

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, Bank T, Cotler SJ, Dhanarajan A, Denning MF, Ding X, Breslin P, Qiang W, Li J, Koleske AJ, et al. ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Gastroenterology. PMID 32171747 DOI: 10.1053/J.Gastro.2020.03.013  0.343
2019 Bielski M, Denning M. 158 Triggering immortalized keratinocyte growth arrest by protein kinase C delta activation Journal of Investigative Dermatology. 139: S28. DOI: 10.1016/J.JID.2019.03.234  0.341
2018 Wyatt DL, Zlobin A, Ma E, Denning MF, Osipo C. Abstract 1831: PKCδ as a novel target for HER2-positive, trastuzumab resistant breast cancer Cancer Research. 78: 1831-1831. DOI: 10.1158/1538-7445.Am2018-1831  0.348
2017 Kim JL, Ha GH, Campo L, Denning MF, Patel TB, Osipo C, Lin SY, Breuer EK. The role of Rak in the regulation of stability and function of BRCA1. Oncotarget. 8: 86799-86815. PMID 29156836 DOI: 10.18632/Oncotarget.5717  0.372
2017 Haick JM, Brueggemann LI, Cribbs LL, Denning MF, Schwartz J, Byron KL. PKC-DEPENDENT REGULATION OF Kv7.5 CHANNELS BY THE BRONCHOCONSTRICTOR HISTAMINE IN HUMAN AIRWAY SMOOTH MUSCLE CELLS. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00567.2016. PMID 28283479 DOI: 10.1152/Ajplung.00567.2016  0.361
2016 Arteaga M, Shang N, Ding X, Yong S, Cotler SJ, Denning MF, Shimamura T, Breslin P, Bernhard L, Qiu W. Inhibition of SIRT2 suppresses hepatic fibrosis. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00271.2015. PMID 27125275 DOI: 10.1152/Ajpgi.00271.2015  0.341
2016 Patil G, Wautlet A, Scheck J, Negro C, Denning M. 572 Protein kinase C delta is a central regulator of DNA damage responses Journal of Investigative Dermatology. 136: S101. DOI: 10.1016/J.Jid.2016.02.611  0.381
2015 Fenton SE, Denning MF. FYNagling divergent adhesive functions for Fyn in keratinocytes. Experimental Dermatology. 24: 81-5. PMID 24980626 DOI: 10.1111/Exd.12485  0.388
2015 Fenton SE, Hutchens KA, Denning MF. Targeting Fyn in Ras-transformed cells induces F-actin to promote adherens junction-mediated cell-cell adhesion. Molecular Carcinogenesis. 54: 1181-93. PMID 24976598 DOI: 10.1002/Mc.22190  0.435
2014 Zhang H, Lin Y, Mañas A, Zhao Y, Denning MF, Ma L, Xiang J. BaxΔ2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. Molecular Cancer Research : McR. 12: 1225-32. PMID 24842234 DOI: 10.1158/1541-7786.Mcr-14-0162  0.471
2013 Wheeler DL, Verma AK, Denning MF. Mouse models of the skin: models to define mechanisms of skin carcinogenesis. Journal of Skin Cancer. 2013: 971495. PMID 23819053 DOI: 10.1155/2013/971495  0.393
2012 Denning MF. Specifying protein kinase C functions in melanoma. Pigment Cell & Melanoma Research. 25: 466-76. PMID 22578192 DOI: 10.1111/J.1755-148X.2012.01015.X  0.423
2012 Mascia F, Denning M, Kopan R, Yuspa SH. The black box illuminated: signals and signaling. The Journal of Investigative Dermatology. 132: 811-9. PMID 22170487 DOI: 10.1038/Jid.2011.406  0.324
2012 Fenton S, Denning MF. Abstract 2864: Regulation and targeting of Fyn in cutaneous squamous cell carcinoma Cancer Research. 72: 2864-2864. DOI: 10.1158/1538-7445.Am2012-2864  0.431
2011 Yadav V, Denning MF. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Molecular Carcinogenesis. 50: 346-52. PMID 21480388 DOI: 10.1002/Mc.20716  0.733
2011 Hobbs RP, Amargo EV, Somasundaram A, Simpson CL, Prakriya M, Denning MF, Green KJ. The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 990-1001. PMID 21156808 DOI: 10.1096/Fj.10-163261  0.401
2011 Denning MF. Protein kinase C and the development of squamous cell carcinoma Signaling Pathways in Squamous Cancer. 165-184. DOI: 10.1007/978-1-4419-7203-3_8  0.407
2010 Denning MF. Protein kinase C/mitogen-activated protein kinase signaling in keratinocyte differentiation control. The Journal of Investigative Dermatology. 130: 1968-70. PMID 20631751 DOI: 10.1038/Jid.2010.194  0.412
2010 Yadav V, Yanez NC, Fenton SE, Denning MF. Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. The American Journal of Pathology. 176: 1091-6. PMID 20093486 DOI: 10.2353/Ajpath.2010.090816  0.758
2010 Voris JP, Sitailo LA, Rahn HR, Defnet A, Gerds AT, Sprague R, Yadav V, Caroline Le Poole I, Denning MF. Functional alterations in protein kinase C beta II expression in melanoma. Pigment Cell & Melanoma Research. 23: 216-24. PMID 20015121 DOI: 10.1111/J.1755-148X.2009.00664.X  0.733
2010 Denning MF. Sun-sensitizing effects of PKCepsilon shine on multiple mouse strains. The Journal of Investigative Dermatology. 130: 17-9. PMID 20010864 DOI: 10.1038/Jid.2009.354  0.363
2010 LaGory EL, Sitailo LA, Denning MF. The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. The Journal of Biological Chemistry. 285: 1879-87. PMID 19917613 DOI: 10.1074/Jbc.M109.055392  0.729
2010 Yadav V, Denning MF. Abstract 5194: Induction of Fyn via the Ras/PI3K pathway is necessary and sufficient for enhanced migration and invasion Cancer Research. 70: 5194-5194. DOI: 10.1158/1538-7445.Am10-5194  0.468
2010 Sitailo L, Sethupathi P, Denning MF. Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes Cancer Research. 70: 1026-1026. DOI: 10.1158/1538-7445.Am10-1026  0.443
2009 Jerome-Morais A, Rahn HR, Tibudan SS, Denning MF. Role for protein kinase C-alpha in keratinocyte growth arrest. The Journal of Investigative Dermatology. 129: 2365-75. PMID 19340015 DOI: 10.1038/Jid.2009.74  0.498
2009 Sitailo LA, Jerome-Morais A, Denning MF. Mcl-1 functions as major epidermal survival protein required for proper keratinocyte differentiation. The Journal of Investigative Dermatology. 129: 1351-60. PMID 19037233 DOI: 10.1038/Jid.2008.363  0.486
2009 Brown MV, Burnett PE, Denning MF, Reynolds AB. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Experimental Cell Research. 315: 39-49. PMID 18950621 DOI: 10.1016/J.Yexcr.2008.09.025  0.436
2008 Yang G, Li Y, Nishimura EK, Xin H, Zhou A, Guo Y, Dong L, Denning MF, Nickoloff BJ, Cui R. Inhibition of PAX3 by TGF-beta modulates melanocyte viability. Molecular Cell. 32: 554-63. PMID 19026785 DOI: 10.1016/J.Molcel.2008.11.002  0.37
2008 Bass-Zubek AE, Hobbs RP, Amargo EV, Garcia NJ, Hsieh SN, Chen X, Wahl JK, Denning MF, Green KJ. Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. The Journal of Cell Biology. 181: 605-13. PMID 18474624 DOI: 10.1083/Jcb.200712133  0.369
2007 Breitkreutz D, Braiman-Wiksman L, Daum N, Denning MF, Tennenbaum T. Protein kinase C family: On the crossroads of cell signaling in skin and tumor epithelium Journal of Cancer Research and Clinical Oncology. 133: 793-808. PMID 17661083 DOI: 10.1007/S00432-007-0280-3  0.477
2007 Denning MF. Tightening the epidermal barrier with atypical PKCs. The Journal of Investigative Dermatology. 127: 742-4. PMID 17363954 DOI: 10.1038/Sj.Jid.5700694  0.346
2006 Qin JZ, Xin H, Sitailo LA, Denning MF, Nickoloff BJ. Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Research. 66: 9636-45. PMID 17018621 DOI: 10.1158/0008-5472.Can-06-0747  0.457
2006 Sitailo LA, Tibudan SS, Denning MF. The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. The Journal of Biological Chemistry. 281: 29703-10. PMID 16901898 DOI: 10.1074/Jbc.M607351200  0.556
2006 Guo H, Miao H, Gerber L, Singh J, Denning MF, Gilliam AC, Wang B. Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Research. 66: 7050-8. PMID 16849550 DOI: 10.1158/0008-5472.Can-06-0004  0.424
2006 Fan J, Guan S, Cheng CF, Cho M, Fields JW, Chen M, Denning MF, Woodley DT, Li W. PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration. The Journal of Investigative Dermatology. 126: 1233-43. PMID 16543902 DOI: 10.1038/Sj.Jid.5700149  0.443
2006 Chaturvedi V, Sitailo LA, Bodner B, Denning MF, Nickoloff BJ. Defining the caspase-containing apoptotic machinery contributing to cornification in human epidermal equivalents. Experimental Dermatology. 15: 14-22. PMID 16364027 DOI: 10.1111/J.0906-6705.2005.00383.X  0.431
2006 D'Costa AM, Robinson JK, Maududi T, Chaturvedi V, Nickoloff BJ, Denning MF. The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. Oncogene. 25: 378-86. PMID 16158048 DOI: 10.1038/Sj.Onc.1209065  0.719
2005 Chaturvedi V, Sitailo LA, Qin JZ, Bodner B, Denning MF, Curry J, Zhang W, Brash D, Nickoloff BJ. Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis. Oncogene. 24: 5299-312. PMID 15940268 DOI: 10.1038/Sj.Onc.1208650  0.429
2005 Alkan S, Huang Q, Ergin M, Denning MF, Nand S, Maududi T, Paner GP, Ozpuyan F, Izban KF. Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. American Journal of Hematology. 79: 97-106. PMID 15929099 DOI: 10.1002/Ajh.20352  0.484
2005 D'Costa AM, Denning MF. A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis. Cell Death and Differentiation. 12: 224-32. PMID 15618968 DOI: 10.1038/Sj.Cdd.4401558  0.702
2004 Sitailo LA, Tibudan SS, Denning MF. Bax activation and induction of apoptosis in human keratinocytes by the protein kinase C delta catalytic domain. The Journal of Investigative Dermatology. 123: 434-43. PMID 15304079 DOI: 10.1111/J.0022-202X.2004.23403.X  0.493
2004 Qin JZ, Bacon P, Panella J, Sitailo LA, Denning MF, Nickoloff BJ. Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis. Journal of Cellular Physiology. 200: 155-66. PMID 15137068 DOI: 10.1002/Jcp.20017  0.421
2004 Denning MF. Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms. The International Journal of Biochemistry & Cell Biology. 36: 1141-6. PMID 15109560 DOI: 10.1016/J.Biocel.2003.12.004  0.429
2003 Chaturvedi V, Bonish B, Bacon P, Qin JZ, Denning MF, Foreman K, Diaz MO, Robinson J, Nickoloff BJ. Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma. Experimental Dermatology. 12: 255-60. PMID 12823438 DOI: 10.1034/J.1600-0625.2003.00066.X  0.41
2003 Ni H, Ergin M, Tibudan SS, Denning MF, Izban KF, Alkan S. Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis British Journal of Haematology. 121: 849-856. PMID 12786795 DOI: 10.1046/j.1365-2141.2003.04368.x  0.406
2002 Nickoloff BJ, Qin JZ, Chaturvedi V, Bacon P, Panella J, Denning MF. Life and death signaling pathways contributing to skin cancer. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 7: 27-35. PMID 12518789 DOI: 10.1046/J.1523-1747.2002.19633.X  0.451
2002 Weinberg WC, Denning MF. P21WAF1 control of epithelial cell cycle and cell fate Critical Reviews in Oral Biology and Medicine. 13: 453-464. PMID 12499239 DOI: 10.1177/154411130201300603  0.413
2002 Tibudan SS, Wang Y, Denning MF. Activation of protein kinase C triggers irreversible cell cycle withdrawal in human keratinocytes. The Journal of Investigative Dermatology. 119: 1282-9. PMID 12485429 DOI: 10.1046/J.1523-1747.2002.19625.X  0.517
2002 Nickoloff BJ, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ Cell Death and Differentiation. 9: 842-855. PMID 12107827 DOI: 10.1038/Sj.Cdd.4401036  0.383
2002 Qin JZ, Chaturvedi V, Denning MF, Bacon P, Panella J, Choubey D, Nickoloff BJ. Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene. 21: 2991-3002. PMID 12082529 DOI: 10.1038/Sj.Onc.1205404  0.479
2002 Sitailo LA, Tibudan SS, Denning MF. Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. The Journal of Biological Chemistry. 277: 19346-52. PMID 11919192 DOI: 10.1074/Jbc.M200401200  0.492
2002 Denning MF, Wang Y, Tibudan S, Alkan S, Nickoloff BJ, Qin JZ. Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C Cell Death and Differentiation. 9: 40-52. PMID 11803373 DOI: 10.1038/sj.cdd.4400929  0.426
2001 Ergin M, Denning MF, Izban KF, Amin HM, Martinez RL, Saeed S, Alkan S. Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein Experimental Hematology. 29: 1082-1090. PMID 11532349 DOI: 10.1016/S0301-472X(01)00688-9  0.497
2001 Alt A, Ohba M, Li L, Gartsbein M, Belanger A, Denning MF, Kuroki T, Yuspa SH, Tennenbaum T. Protein kinase Cδ-mediated phosphorylation of α6β4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment Cancer Research. 61: 4591-4598. PMID 11389095  0.328
2001 Park GT, Denning MF, Morasso MI. Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C Febs Letters. 496: 60-65. PMID 11343707 DOI: 10.1016/S0014-5793(01)02398-5  0.447
2001 Chaturvedi V, Qin JZ, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. Abnormal NF-κB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytes Journal of Dermatological Science. 26: 67-78. PMID 11323223 DOI: 10.1016/S0923-1811(00)00157-2  0.505
2000 Amin HM, Ergin M, Denning MF, Quevedo ME, Alkan S. Characterization of apoptosis induced by protein kinase C inhibitors and its modulation by the caspase pathway in acute promyelocytic leukaemia British Journal of Haematology. 110: 552-562. PMID 10997964 DOI: 10.1046/J.1365-2141.2000.02207.X  0.529
2000 Nickoloff BJ, Chaturvedi V, Bacon P, Qin JZ, Denning MF, Diaz MO. Id-1 delays senescence but does not immortalize keratinocytes Journal of Biological Chemistry. 275: 27501-27504. PMID 10908559 DOI: 10.1074/Jbc.C000311200  0.437
2000 Denning MF, Dlugosz AA, Cheng C, Dempsey PJ, Coffey RJ, Threadgill DW, Magnuson T, Yuspa SH. Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes Experimental Dermatology. 9: 192-199. PMID 10839717 DOI: 10.1034/J.1600-0625.2000.009003192.X  0.435
2000 Amin HM, Ergin M, Denning MF, Saeed S, Alkan S. Expression of protein kinase c (pkc) isoforms and the effect of selective pkc-s inhibition by rottlerin on the induction of apoptosis in acute promyelocytic leukemia Blood. 96.  0.39
1999 Qin JZ, Chaturvedi V, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. Role of NF-κB in the apoptotic-resistant phenotype of keratinocytes Journal of Biological Chemistry. 274: 37957-37964. PMID 10608863 DOI: 10.1074/Jbc.274.53.37957  0.426
1999 Chaturvedi V, Qin JZ, Denning MF, Choubey D, Diaz MO, Nickoloff BJ. Apoptosis in proliferating, senescent, and immortalized keratinocytes Journal of Biological Chemistry. 274: 23358-23367. PMID 10438513 DOI: 10.1074/Jbc.274.33.23358  0.523
1998 Denning MF, Wang Y, Nickoloff BJ, Wrone-Smith T. Protein kinase Cσ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes Journal of Biological Chemistry. 273: 29995-30002. PMID 9792720 DOI: 10.1074/Jbc.273.45.29995  0.543
1998 Denning MF, Guy SG, Ellerbroek SM, Norvell SM, Kowalczyk AP, Green KJ. The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C. Experimental Cell Research. 239: 50-9. PMID 9511724 DOI: 10.1006/Excr.1997.3890  0.348
1998 Denning M, Kowalczyk A, Borgwardt J, Green K. Disruption of desmosomes by activated SRC family kinases Journal of Dermatological Science. 16: S3. DOI: 10.1016/S0923-1811(98)83013-2  0.35
1996 Stanwell C, Denning MF, Rutberg SE, Cheng C, Yuspa SH, Dlugosz AA. Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes Journal of Investigative Dermatology. 106: 482-489. PMID 8648181 DOI: 10.1111/1523-1747.Ep12343690  0.4
1996 Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C δ Journal of Biological Chemistry. 271: 5325-5331. PMID 8621384 DOI: 10.1074/Jbc.271.10.5325  0.37
1995 Denning MF, Kazanietz MG, Blumberg PM, Yuspa SH. Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes Cell Growth and Differentiation. 6: 1619-1626. PMID 9019167  0.335
1994 Punnonen K, Denning MF, Rhee SG, Yuspa SH. Differences in the regulation of phosphatidylinositol-specific phospholipase C in normal and neoplastic keratinocytes Molecular Carcinogenesis. 10: 216-225. PMID 8068182 DOI: 10.1002/Mc.2940100406  0.414
1994 Dlugosz AA, Cheng C, Williams EK, Dharia AG, Denning MF, Yuspa SH. Alterations in Murine Keratinocyte Differentiation Induced by Activated rasHa Genes Are Mediated by Protein Kinase C-a Cancer Research. 54: 6413-6420. PMID 7987836  0.324
1994 Szallasi Z, Denning MF, Smith CB, Dlugosz AA, Yuspa SH, Pettit GR, Blumberg PM. Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation. Molecular Pharmacology. 46: 840-50. PMID 7969070  0.352
1994 Yuspa SH, Dlugosz AA, Cheng CK, Denning MF, Tennenbaum T, Glick AB, Weinberg WC. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis Journal of Investigative Dermatology. 103. PMID 7963691 DOI: 10.1038/Jid.1994.16  0.433
1993 Denning MF, Dlugosz AA, Howett MK, Yuspa SH. Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ Journal of Biological Chemistry. 268: 26079-26081. PMID 8253722  0.4
1993 Punnonen K, Denning M, Lee E, Li L, Rhee SG, Yuspa SH. Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes. The Journal of Investigative Dermatology. 101: 719-26. PMID 8228334 DOI: 10.1111/1523-1747.Ep12371682  0.395
1993 Dlugosz AA, Cheng C, Denning MF, Dempsey PJ, Coffey RJ, Yuspa SH. KGF induces TGFα expression and activates the EGF receptor signaling pathway to alter keratinocyte growth and differentiation in vitro Journal of Dermatological Science. 6: 41. DOI: 10.1016/0923-1811(93)90954-N  0.402
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