| Year |
Citation |
Score |
| 2022 |
Roth RA, Kana O, Filipovic D, Ganey PE. Pharmacokinetic and toxicodynamic concepts in idiosyncratic, drug-induced liver injury. Expert Opinion On Drug Metabolism & Toxicology. 1-13. PMID 36003040 DOI: 10.1080/17425255.2022.2113379 |
0.322 |
|
| 2021 |
Olivero-Verbel J, Harkema JR, Roth RA, Ganey PE. Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, blocks steatosis and alters the inflammatory response in a mouse model of inflammation-dioxin interaction. Chemico-Biological Interactions. 109521. PMID 34052195 DOI: 10.1016/j.cbi.2021.109521 |
0.454 |
|
| 2020 |
Roth RA, Ganey PE. What have we learned from animal models of idiosyncratic, drug-induced liver injury? Expert Opinion On Drug Metabolism & Toxicology. 1-17. PMID 32324077 DOI: 10.1080/17425255.2020.1760246 |
0.42 |
|
| 2020 |
Hastings KL, Green MD, Gao B, Ganey PE, Roth RA, Burleson GR. Beyond Metabolism: Role of the Immune System in Hepatic Toxicity. International Journal of Toxicology. 39: 151-164. PMID 32174281 DOI: 10.1177/1091581819898399 |
0.395 |
|
| 2017 |
Maiuri AR, Wassink B, Turkus JD, Breier AB, Lansdell T, Kaur G, Hession SL, Ganey PE, Roth RA. Synergistic Cytotoxicity from Drugs and Cytokines in Vitro as an Approach to Classify Drugs According to their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof of Concept Study. The Journal of Pharmacology and Experimental Therapeutics. PMID 28687704 DOI: 10.1124/Jpet.117.242354 |
0.326 |
|
| 2017 |
Roth RA, Maiuri AR, Ganey PE. Idiosyncratic Drug-Induced Liver Injury: Is Drug-Cytokine Interaction the Linchpin? The Journal of Pharmacology and Experimental Therapeutics. 360: 461-470. PMID 28104833 DOI: 10.1124/Jpet.116.237578 |
0.415 |
|
| 2015 |
Maiuri AR, Breier AB, Turkus JD, Ganey PE, Roth RA. Calcium Contributes to the Cytotoxic Interaction between Diclofenac and Cytokines. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26609140 DOI: 10.1093/Toxsci/Kfv249 |
0.449 |
|
| 2015 |
Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA. Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood. PMID 26179083 DOI: 10.1182/Blood-2014-09-598656 |
0.458 |
|
| 2015 |
Miyakawa K, Albee R, Letzig LG, Lehner AF, Scott MA, Buchweitz JP, James LP, Ganey PE, Roth RA. A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 354: 230-7. PMID 26065700 DOI: 10.1124/Jpet.115.223537 |
0.342 |
|
| 2015 |
Maiuri AR, Breier AB, Gora LF, Parkins RV, Ganey PE, Roth RA. Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases. Toxicological Sciences : An Official Journal of the Society of Toxicology. 146: 265-80. PMID 25953702 DOI: 10.1093/Toxsci/Kfv091 |
0.417 |
|
| 2015 |
Beggs KM, Maiuri AR, Fullerton AM, Poulsen KL, Breier AB, Ganey PE, Roth RA. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology. 331: 35-46. PMID 25748550 DOI: 10.1016/J.Tox.2015.03.002 |
0.725 |
|
| 2014 |
Poulsen KL, Olivero-Verbel J, Beggs KM, Ganey PE, Roth RA. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response. The Journal of Pharmacology and Experimental Therapeutics. 350: 164-70. PMID 24817034 DOI: 10.1124/Jpet.114.214189 |
0.52 |
|
| 2014 |
Poulsen KL, Albee RP, Ganey PE, Roth RA. Trovafloxacin potentiation of lipopolysaccharide-induced tumor necrosis factor release from RAW 264.7 cells requires extracellular signal-regulated kinase and c-Jun N-Terminal Kinase. The Journal of Pharmacology and Experimental Therapeutics. 349: 185-91. PMID 24525298 DOI: 10.1124/Jpet.113.211276 |
0.526 |
|
| 2014 |
Beggs KM, Fullerton AM, Miyakawa K, Ganey PE, Roth RA. Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction. Toxicological Sciences : An Official Journal of the Society of Toxicology. 137: 91-101. PMID 24097668 DOI: 10.1093/Toxsci/Kft226 |
0.736 |
|
| 2013 |
Fullerton AM, Roth RA, Ganey PE. Pretreatment with TCDD exacerbates liver injury from Concanavalin A: critical role for NK cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 136: 72-85. PMID 23970800 DOI: 10.1093/Toxsci/Kft174 |
0.759 |
|
| 2013 |
Lu J, Roth RA, Malle E, Ganey PE. Roles of the hemostatic system and neutrophils in liver injury from co-exposure to amiodarone and lipopolysaccharide. Toxicological Sciences : An Official Journal of the Society of Toxicology. 136: 51-62. PMID 23912913 DOI: 10.1093/Toxsci/Kft170 |
0.721 |
|
| 2013 |
Fullerton AM, Roth RA, Ganey PE. 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicology and Applied Pharmacology. 266: 317-27. PMID 23164664 DOI: 10.1016/J.Taap.2012.11.009 |
0.757 |
|
| 2013 |
Lu J, Miyakawa K, Roth RA, Ganey PE. Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress. Toxicological Sciences : An Official Journal of the Society of Toxicology. 131: 164-78. PMID 23042730 DOI: 10.1093/Toxsci/Kfs289 |
0.611 |
|
| 2013 |
Roth RA, Ganey PE. Role of inflammation in drug-induced liver injury Drug-Induced Liver Disease. 157-173. DOI: 10.1016/B978-0-12-387817-5.00010-8 |
0.326 |
|
| 2012 |
Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, Watkins PB, Albassam M, Liu B, Stancic S, Suter L, Bortolini M. Current challenges and controversies in drug-induced liver injury. Drug Safety. 35: 1099-117. PMID 23137150 DOI: 10.2165/11632970-000000000-00000 |
0.4 |
|
| 2012 |
Coen M, Rademacher PM, Zou W, Scott M, Ganey PE, Roth R, Nelson SD. Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer. Chemical Research in Toxicology. 25: 2412-22. PMID 23013248 DOI: 10.1021/Tx3002803 |
0.327 |
|
| 2012 |
Singhal R, Ganey PE, Roth RA. Complement activation in acetaminophen-induced liver injury in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 377-85. PMID 22319198 DOI: 10.1124/Jpet.111.189837 |
0.51 |
|
| 2012 |
Sparkenbaugh EM, Ganey PE, Roth RA. Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1α. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G748-57. PMID 22223132 DOI: 10.1152/Ajpgi.00409.2011 |
0.381 |
|
| 2012 |
Lu J, Jones AD, Harkema JR, Roth RA, Ganey PE. Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 126-33. PMID 21984482 DOI: 10.1093/Toxsci/Kfr266 |
0.725 |
|
| 2011 |
Zou W, Roth RA, Younis HS, Malle E, Ganey PE. Neutrophil-cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury. Toxicology. 290: 278-85. PMID 22019926 DOI: 10.1016/J.Tox.2011.10.005 |
0.585 |
|
| 2011 |
Roth RA, Ganey PE. Animal models of idiosyncratic drug-induced liver injury--current status. Critical Reviews in Toxicology. 41: 723-39. PMID 21726137 DOI: 10.3109/10408444.2011.575765 |
0.39 |
|
| 2011 |
Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA. The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 338: 492-502. PMID 21576378 DOI: 10.1124/Jpet.111.180521 |
0.468 |
|
| 2011 |
Dugan CM, Fullerton AM, Roth RA, Ganey PE. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 507-18. PMID 21245496 DOI: 10.1093/Toxsci/Kfr005 |
0.789 |
|
| 2011 |
Olivero-Verbel J, Roth RA, Ganey PE. Dioxin alters inflammatory responses to lipopolysaccharide Toxicological and Environmental Chemistry. 93: 1180-1194. DOI: 10.1080/02772248.2011.577554 |
0.502 |
|
| 2010 |
Liguori MJ, Ditewig AC, Maddox JF, Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Waring JF, Ganey PE, Roth RA, Blomme EA. Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example. International Journal of Molecular Sciences. 11: 4697-714. PMID 21151465 DOI: 10.3390/Ijms11114697 |
0.467 |
|
| 2010 |
Shaw PJ, Ganey PE, Roth RA. Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 118: 7-18. PMID 20538741 DOI: 10.1093/Toxsci/Kfq168 |
0.374 |
|
| 2010 |
Zou W, Roth RA, Younis HS, Burgoon LD, Ganey PE. Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment. Toxicology. 272: 32-8. PMID 20371263 DOI: 10.1016/J.Tox.2010.03.015 |
0.564 |
|
| 2010 |
Dugan CM, MacDonald AE, Roth RA, Ganey PE. A mouse model of severe halothane hepatitis based on human risk factors. The Journal of Pharmacology and Experimental Therapeutics. 333: 364-72. PMID 20124411 DOI: 10.1124/Jpet.109.164541 |
0.802 |
|
| 2010 |
Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR. Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 267-85. PMID 20123758 DOI: 10.1093/Toxsci/Kfq034 |
0.43 |
|
| 2010 |
Roth RA, Ganey PE. Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one? The Journal of Pharmacology and Experimental Therapeutics. 332: 692-7. PMID 20019161 DOI: 10.1124/Jpet.109.162651 |
0.395 |
|
| 2010 |
Maddox JF, Amuzie CJ, Li M, Newport SW, Sparkenbaugh E, Cuff CF, Pestka JJ, Cantor GH, Roth RA, Ganey PE. Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. Journal of Toxicology and Environmental Health. Part A. 73: 58-73. PMID 19953420 DOI: 10.1080/15287390903249057 |
0.566 |
|
| 2010 |
Traore K, Singhal R, Rivera R, Ganey PE, Roth RA. Abstract 4378: Aflatoxin B1 inhibits LPS-induced TNF-alpha production in RAW 264.7 cells Cancer Research. 70: 4378-4378. DOI: 10.1158/1538-7445.Am10-4378 |
0.446 |
|
| 2009 |
Deng X, Luyendyk JP, Ganey PE, Roth RA. Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models. Pharmacological Reviews. 61: 262-82. PMID 19805476 DOI: 10.1124/Pr.109.001727 |
0.329 |
|
| 2009 |
Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, Ganey PE. Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury. The Journal of Pharmacology and Experimental Therapeutics. 331: 114-21. PMID 19638570 DOI: 10.1124/Jpet.109.156331 |
0.553 |
|
| 2009 |
Shaw PJ, Beggs KM, Sparkenbaugh EM, Dugan CM, Ganey PE, Roth RA. Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 111: 288-301. PMID 19638433 DOI: 10.1093/Toxsci/Kfp163 |
0.82 |
|
| 2009 |
Shaw PJ, Fullerton AM, Scott MA, Ganey PE, Roth RA. The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability. Toxicology and Applied Pharmacology. 236: 293-300. PMID 19367693 DOI: 10.1016/J.Taap.2009.01.018 |
0.782 |
|
| 2009 |
Shaw PJ, Ganey PE, Roth RA. Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice. The Journal of Pharmacology and Experimental Therapeutics. 330: 72-8. PMID 19351866 DOI: 10.1124/Jpet.109.151068 |
0.526 |
|
| 2009 |
Zou W, Devi SS, Sparkenbaugh E, Younis HS, Roth RA, Ganey PE. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 184-93. PMID 19074762 DOI: 10.1093/Toxsci/Kfn259 |
0.572 |
|
| 2009 |
Shaw PJ, Ditewig AC, Waring JF, Liguori MJ, Blomme EA, Ganey PE, Roth RA. Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 107: 270-80. PMID 18930950 DOI: 10.1093/Toxsci/Kfn205 |
0.463 |
|
| 2009 |
Shaw PJ, Ganey PE, Roth RA. Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure. The Journal of Pharmacology and Experimental Therapeutics. 328: 62-8. PMID 18820134 DOI: 10.1124/Jpet.108.143792 |
0.571 |
|
| 2009 |
Roth RA, Ganey PE. Inflammation and Drug-Induced Liver Injury The Liver: Biology and Pathobiology: Fifth Edition. 773-781. DOI: 10.1002/9780470747919.ch47 |
0.348 |
|
| 2008 |
Deng X, Liguori MJ, Sparkenbaugh EM, Waring JF, Blomme EA, Ganey PE, Roth RA. Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury. The Journal of Pharmacology and Experimental Therapeutics. 327: 634-44. PMID 18801949 DOI: 10.1124/Jpet.108.140335 |
0.471 |
|
| 2008 |
Deng X, Lu J, Lehman-McKeeman LD, Malle E, Crandall DL, Ganey PE, Roth RA. p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. The Journal of Pharmacology and Experimental Therapeutics. 326: 144-52. PMID 18390808 DOI: 10.1124/Jpet.108.137497 |
0.69 |
|
| 2007 |
Shaw PJ, Hopfensperger MJ, Ganey PE, Roth RA. Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 259-66. PMID 17709330 DOI: 10.1093/Toxsci/Kfm218 |
0.557 |
|
| 2007 |
Tukov FF, Luyendyk JP, Ganey PE, Roth RA. The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 267-80. PMID 17698507 DOI: 10.1093/Toxsci/Kfm209 |
0.544 |
|
| 2007 |
Ganey PE, Luyendyk JP, Newport SW, Eagle TM, Maddox JF, Mackman N, Roth RA. Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology (Baltimore, Md.). 46: 1177-86. PMID 17654741 DOI: 10.1002/Hep.21779 |
0.49 |
|
| 2007 |
Deng X, Luyendyk JP, Zou W, Lu J, Malle E, Ganey PE, Roth RA. Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. The Journal of Pharmacology and Experimental Therapeutics. 322: 852-61. PMID 17505017 DOI: 10.1124/Jpet.107.122069 |
0.711 |
|
| 2007 |
Bezdecny SA, Karmaus P, Roth RA, Ganey PE. 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. Toxicology and Applied Pharmacology. 221: 285-94. PMID 17482227 DOI: 10.1016/J.Taap.2007.03.019 |
0.759 |
|
| 2007 |
Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 96: 2-15. PMID 17122412 DOI: 10.1093/Toxsci/Kfl173 |
0.46 |
|
| 2006 |
Deng X, Stachlewitz RF, Liguori MJ, Blomme EA, Waring JF, Luyendyk JP, Maddox JF, Ganey PE, Roth RA. Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. The Journal of Pharmacology and Experimental Therapeutics. 319: 1191-9. PMID 16990511 DOI: 10.1124/Jpet.106.110247 |
0.559 |
|
| 2006 |
Copple BL, Roth RA, Ganey PE. Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure. Toxicology. 225: 128-37. PMID 16828949 DOI: 10.1016/J.Tox.2006.05.016 |
0.487 |
|
| 2006 |
Tukov FF, Maddox JF, Amacher DE, Bobrowski WF, Roth RA, Ganey PE. Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 1488-99. PMID 16782301 DOI: 10.1016/J.Tiv.2006.04.005 |
0.473 |
|
| 2006 |
Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Maddox JF, Ganey PE, Roth RA. Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 90: 569-85. PMID 16415329 DOI: 10.1093/Toxsci/Kfj103 |
0.51 |
|
| 2006 |
Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Deng X, Maddox JF, Ganey PE, Roth RA. Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine. The Journal of Pharmacology and Experimental Therapeutics. 317: 635-43. PMID 16401727 DOI: 10.1124/Jpet.105.096305 |
0.518 |
|
| 2006 |
Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF, North C, Blomme EA, Roth RA. Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. The Journal of Pharmacology and Experimental Therapeutics. 316: 1080-7. PMID 16299187 DOI: 10.1124/Jpet.105.096347 |
0.547 |
|
| 2006 |
Maddox JF, Luyendyk JP, Cosma GN, Breau AP, Bible RH, Harrigan GG, Goodacre R, Ganey PE, Cantor GH, Cockerell GL, Roth RA. Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicology and Applied Pharmacology. 212: 35-44. PMID 16051291 DOI: 10.1016/J.Taap.2005.06.021 |
0.527 |
|
| 2005 |
Luyendyk JP, Shaw PJ, Green CD, Maddox JF, Ganey PE, Roth RA. Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. The Journal of Pharmacology and Experimental Therapeutics. 314: 1023-31. PMID 15933155 DOI: 10.1124/Jpet.105.087981 |
0.578 |
|
| 2005 |
Luster-Teasley SL, Ganey PE, DiOrio M, Ward JS, Maleczka RE, Trosko JE, Masten SJ. Effect of byproducts from the ozonation of pyrene: biphenyl-2,2',6,6'-tetracarbaldehyde and biphenyl-2,2',6,6'-tetracarboxylic acid on gap junction intercellular communication and neutrophil function. Environmental Toxicology and Chemistry / Setac. 24: 733-40. PMID 15786580 DOI: 10.1897/04-679.1 |
0.327 |
|
| 2005 |
Bezdecny SA, Roth RA, Ganey PE. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Toxicological Sciences : An Official Journal of the Society of Toxicology. 84: 328-34. PMID 15673847 DOI: 10.1093/Toxsci/Kfi093 |
0.774 |
|
| 2004 |
Luyendyk JP, Maddox JF, Green CD, Ganey PE, Roth RA. Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology (Baltimore, Md.). 40: 1342-51. PMID 15565632 DOI: 10.1002/Hep.20492 |
0.557 |
|
| 2004 |
Ganey PE, Luyendyk JP, Maddox JF, Roth RA. Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chemico-Biological Interactions. 150: 35-51. PMID 15522260 DOI: 10.1016/J.Cbi.2004.09.002 |
0.325 |
|
| 2004 |
Kinser S, Sneed R, Roth R, Ganey P. Neutrophils contribute to endotoxin enhancement of allyl alcohol hepatotoxicity. Journal of Toxicology and Environmental Health. Part A. 67: 911-28. PMID 15205035 DOI: 10.1080/15287390490443704 |
0.79 |
|
| 2004 |
Luyendyk JP, Mattes WB, Burgoon LD, Zacharewski TR, Maddox JF, Cosma GN, Ganey PE, Roth RA. Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 203-13. PMID 15084757 DOI: 10.1093/Toxsci/Kfh146 |
0.543 |
|
| 2004 |
Harrigan GG, LaPlante RH, Cosma GN, Cockerell G, Goodacre R, Maddox JF, Luyendyk JP, Ganey PE, Roth RA. Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicology Letters. 146: 197-205. PMID 14687757 DOI: 10.1016/J.Toxlet.2003.09.011 |
0.347 |
|
| 2004 |
Maddox JF, Domzalski AC, Roth RA, Ganey PE. 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 77: 290-8. PMID 14657518 DOI: 10.1093/Toxsci/Kfh028 |
0.43 |
|
| 2004 |
Copple BL, Rondelli CM, Maddox JF, Hoglen NC, Ganey PE, Roth RA. Modes of cell death in rat liver after monocrotaline exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 77: 172-82. PMID 14600277 DOI: 10.1093/Toxsci/Kfh011 |
0.481 |
|
| 2003 |
Hanumegowda UM, Copple BL, Shibuya M, Malle E, Ganey PE, Roth RA. Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 76: 237-46. PMID 12970574 DOI: 10.1093/Toxsci/Kfg222 |
0.417 |
|
| 2003 |
Copple BL, Ganey PE, Roth RA. Liver inflammation during monocrotaline hepatotoxicity. Toxicology. 190: 155-69. PMID 12927372 DOI: 10.1016/S0300-483X(03)00164-1 |
0.542 |
|
| 2003 |
Luyendyk JP, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, Roth RA. Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. The Journal of Pharmacology and Experimental Therapeutics. 307: 9-16. PMID 12893837 DOI: 10.1124/Jpet.103.054288 |
0.551 |
|
| 2003 |
Yee SB, Harkema JR, Ganey PE, Roth RA. The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide. Toxicological Sciences : An Official Journal of the Society of Toxicology. 74: 457-69. PMID 12773766 DOI: 10.1093/Toxsci/Kfg129 |
0.548 |
|
| 2003 |
Maddox JF, Roth RA, Ganey PE. Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. Chemical Research in Toxicology. 16: 609-15. PMID 12755590 DOI: 10.1021/Tx025655N |
0.41 |
|
| 2003 |
Yee SB, Hanumegowda UM, Copple BL, Shibuya M, Ganey PE, Roth RA. Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 74: 203-14. PMID 12730616 DOI: 10.1093/Toxsci/Kfg106 |
0.5 |
|
| 2003 |
Copple BL, Moulin F, Hanumegowda UM, Ganey PE, Roth RA. Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers. The Journal of Pharmacology and Experimental Therapeutics. 305: 417-25. PMID 12606620 DOI: 10.1124/Jpet.102.046391 |
0.583 |
|
| 2003 |
Luyendyk JP, Copple BL, Barton CC, Ganey PE, Roth RA. Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system. Toxicological Sciences : An Official Journal of the Society of Toxicology. 72: 171-81. PMID 12604847 DOI: 10.1093/Toxsci/Kfg007 |
0.556 |
|
| 2003 |
Yee SB, Hanumegowda UM, Hotchkiss JA, Ganey PE, Roth RA. Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 72: 43-56. PMID 12604833 DOI: 10.1093/Toxsci/Kfg019 |
0.547 |
|
| 2003 |
Yee SB, Ganey PE, Roth RA. The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 71: 124-32. PMID 12520082 DOI: 10.1093/Toxsci/71.1.124 |
0.561 |
|
| 2002 |
Kinser S, Copple BL, Roth RA, Ganey PE. Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 69: 470-81. PMID 12377996 DOI: 10.1093/Toxsci/69.2.470 |
0.829 |
|
| 2002 |
Yee SB, Copple BL, Ganey PE, Roth RA. The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality. Journal of Toxicology and Environmental Health. Part A. 65: 961-76. PMID 12133231 DOI: 10.1080/00984100290071261 |
0.494 |
|
| 2002 |
Luyendyk JP, Shores KC, Ganey PE, Roth RA. Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 220-5. PMID 12075124 DOI: 10.1093/Toxsci/68.1.220 |
0.536 |
|
| 2002 |
Copple BL, Woolley B, Banes A, Ganey PE, Roth RA. Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat. Toxicology and Applied Pharmacology. 180: 186-96. PMID 12009858 DOI: 10.1006/Taap.2002.9394 |
0.508 |
|
| 2002 |
Olivero J, Bezdecny SA, Ganey PE. A molecular motif required for the activation of rat neutrophil phospholipase A(2) by organochlorine compounds. Chemical Research in Toxicology. 15: 153-9. PMID 11849040 DOI: 10.1021/Tx0155449 |
0.752 |
|
| 2002 |
Copple BL, Banes A, Ganey PE, Roth RA. Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 65: 309-18. PMID 11812935 DOI: 10.1093/Toxsci/65.2.309 |
0.475 |
|
| 2002 |
Buchweitz JP, Ganey PE, Bursian SJ, Roth RA. Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? The Journal of Pharmacology and Experimental Therapeutics. 300: 460-7. PMID 11805205 DOI: 10.1124/Jpet.300.2.460 |
0.472 |
|
| 2001 |
Ganey PE, Roth RA. Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents Toxicology. 169: 195-208. PMID 11718960 DOI: 10.1016/S0300-483X(01)00523-6 |
0.441 |
|
| 2001 |
Moulin F, Copple BL, Ganey PE, Roth RA. Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure American Journal of Physiology - Gastrointestinal and Liver Physiology. 281. PMID 11705747 DOI: 10.1152/Ajpgi.2001.281.6.G1423 |
0.567 |
|
| 2001 |
Ganey PE, Barton YW, Kinser S, Sneed RA, Barton CC, Roth RA. Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide. Toxicology and Applied Pharmacology. 174: 113-21. PMID 11446826 DOI: 10.1006/Taap.2001.9183 |
0.796 |
|
| 2001 |
Barton CC, Barton EX, Ganey PE, Kunkel SL, Roth RA. Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor α Hepatology. 33: 66-73. PMID 11124822 DOI: 10.1053/Jhep.2001.20643 |
0.487 |
|
| 2000 |
Barton CC, Ganey PE, Roth RA. Lipopolysaccharide augments aflatoxin B1-induced liver injury through neutrophil-dependent and -independent mechanisms Toxicological Sciences. 58: 208-215. PMID 11053557 DOI: 10.1093/Toxsci/58.1.208 |
0.567 |
|
| 2000 |
Yee SB, Kinser S, Hill DA, Barton CC, Hotchkiss JA, Harkema JR, Ganey PE, Roth RA. Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline. Toxicology and Applied Pharmacology. 166: 173-85. PMID 10906281 DOI: 10.1006/Taap.2000.8968 |
0.818 |
|
| 2000 |
Sneed RA, Buchweitz JP, Jean PA, Ganey PE. Pentoxifylline attenuates bacterial lipopolysaccharide-induced enhancement of allyl alcohol hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 203-10. PMID 10869469 DOI: 10.1093/Toxsci/56.1.203 |
0.827 |
|
| 2000 |
Barton CC, Hill DA, Yee SB, Barton EX, Ganey PE, Roth RA. Bacterial lipopolysaccharide exposure augments aflatoxin B1-induced liver injury Toxicological Sciences. 55: 444-452. PMID 10828277 DOI: 10.1093/toxsci/55.2.444 |
0.454 |
|
| 2000 |
Olivero J, Ganey PE. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242 Toxicology and Applied Pharmacology. 163: 9-16. PMID 10662600 DOI: 10.1006/Taap.1999.8827 |
0.351 |
|
| 2000 |
Tithof PK, Olivero J, Ruehle K, Ganey PE. Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds Toxicological Sciences. 53: 40-47. PMID 10653519 DOI: 10.1093/Toxsci/53.1.40 |
0.316 |
|
| 2000 |
Ganey PE, Quensen JF, Mousa MA, Boyd SA, Wagner MA, Fischer LJ. Biological activity associated with noncoplanar polychlorinated biphenyls after microbial dechlorination of Aroclor 1242® and aroclor 1254® Environmental Toxicology and Chemistry. 19: 1311-1316. DOI: 10.1002/Etc.5620190513 |
0.319 |
|
| 1998 |
Brown AP, Olivero-Verbel J, Holdan WL, Ganey PE. Neutrophil activation by polychlorinated biphenyls: Structure-activity relationship Toxicological Sciences. 46: 308-316. PMID 10048134 DOI: 10.1006/Toxs.1998.2551 |
0.303 |
|
| 1998 |
Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer LJ, Boyd SA. Altered biologic activities of commercial polychlorinated biphenyl mixtures after microbial reductive dechlorination. Environmental Health Perspectives. 106: 1409-18. PMID 9860899 DOI: 10.1289/Ehp.98106S61409 |
0.335 |
|
| 1998 |
Olivero-Verbel J, Ganey PE. Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils Toxicology Letters. 98: 195-202. PMID 9788588 DOI: 10.1016/S0378-4274(98)00117-9 |
0.391 |
|
| 1998 |
Narayanan PK, Carter WO, Ganey PE, Roth RA, Voytik-Harbin SL, Robinson JP. Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: Inhibition of superoxide dismutase activity Journal of Leukocyte Biology. 63: 216-224. PMID 9468280 DOI: 10.1002/Jlb.63.2.216 |
0.336 |
|
| 1997 |
Molnar RG, Wang P, Ayala A, Ganey PE, Roth RA, Chaudry IH. The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats Journal of Surgical Research. 73: 117-122. PMID 9441804 DOI: 10.1006/Jsre.1997.5216 |
0.325 |
|
| 1997 |
Tithof PK, Watts S, Ganey PE. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to aroclor 1242, a mixture of polychlorinated biphenyls Biochemical Pharmacology. 53: 1833-1842. PMID 9256158 DOI: 10.1016/S0006-2952(97)82447-1 |
0.325 |
|
| 1997 |
Srinivasan R, Buchweitz JP, Ganey PE. Alteration by flutamide of neutrophil response to stimulation: Implications for tissue injury Biochemical Pharmacology. 53: 1179-1185. PMID 9175723 DOI: 10.1016/S0006-2952(97)00099-3 |
0.481 |
|
| 1997 |
Sneed RA, Grimes SD, Schultze AE, Brown AP, Ganey PE. Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol. Toxicology and Applied Pharmacology. 144: 77-87. PMID 9169072 DOI: 10.1006/Taap.1997.8115 |
0.823 |
|
| 1997 |
Brown AP, Harkema JR, Eric Schultze A, Roth RA, Ganey PE. Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration Shock. 7: 186-192. PMID 9068084 DOI: 10.1097/00024382-199703000-00006 |
0.551 |
|
| 1996 |
Moulin F, Pearson JM, Schultze AE, Scott MA, Schwartz KA, Davis JM, Ganey PE, Roth RA. Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat Journal of Surgical Research. 65: 149-158. PMID 8903462 DOI: 10.1006/Jsre.1996.0358 |
0.558 |
|
| 1996 |
Tithof PK, Schiamberg E, Peters-Golden M, Ganey PE. Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls Environmental Health Perspectives. 104: 52-58. PMID 8834862 DOI: 10.2307/3432760 |
0.309 |
|
| 1996 |
Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. Mechanisms of inflammatory liver injury: Adhesion molecules and cytotoxicity of neutrophils Toxicology and Applied Pharmacology. 139: 213-226. PMID 8806837 DOI: 10.1006/taap.1996.0160 |
0.381 |
|
| 1996 |
Pearson JM, Brown AP, Schultze AE, Ganey PE, Roth RA. Gadolinium chloride treatment attenuates hepatic platelet accumulation after lipopolysaccharide administration Shock. 5: 408-415. PMID 8799952 |
0.465 |
|
| 1996 |
Brown AP, Schultze AE, Holdan WL, Buchweitz JP, Roth RA, Ganey PE. Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls Environmental Health Perspectives. 104: 634-640. PMID 8793352 DOI: 10.1289/Ehp.96104634 |
0.578 |
|
| 1996 |
Wagner JG, Ganey PE, Roth RA. Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucylphenylalanine or phorbol myristate acetate in vitro. Hepatology (Baltimore, Md.). 23: 803-10. PMID 8666335 DOI: 10.1002/Hep.510230422 |
0.434 |
|
| 1996 |
Ho JS, Buchweitz JP, Roth RA, Ganey PE. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes Journal of Leukocyte Biology. 59: 716-724. PMID 8656057 DOI: 10.1002/Jlb.59.5.716 |
0.398 |
|
| 1995 |
Ganey PE, Schultze AE. Depletion of neutrophils and modulation of Kupffer cell function in allyl alcohol-induced hepatotoxicity Toxicology. 99: 99-106. PMID 7762005 DOI: 10.1016/0300-483X(94)03005-M |
0.387 |
|
| 1995 |
Brown AP, Ganey PE. Neutrophil Degranulation and Superoxide Production Induced by Polychlorinated Biphenyls Are Calcium Dependent Toxicology and Applied Pharmacology. 131: 198-205. PMID 7716762 DOI: 10.1006/Taap.1995.1062 |
0.307 |
|
| 1994 |
Ganey PE, Bailie MB, VanCise S, Colligan ME, Madhukar BV, Robinson JP, Roth RA. Activated neutrophils from rat injured isolated hepatocytes Laboratory Investigation. 70: 53-60. PMID 8302018 |
0.3 |
|
| 1993 |
Ganey PE, Sirois JE, Denison M, Robinson JP, Roth RA. Neutrophil function after exposure to polychlorinated biphenyls in vitro Environmental Health Perspectives. 101: 430-434. PMID 8119254 DOI: 10.1289/Ehp.93101430 |
0.323 |
|
| 1991 |
Ganey PE, Keller B, Lichtman SN, Lemasters JJ, Thurman RG. A new method to monitor Kupffer cell phagocytosis continuously in perfused rat liver Hepatology. 13: 567-574. PMID 1999326 |
0.341 |
|
| 1991 |
Ganey PE, Keller B, Lichtman SN, Lemasters JJ, Thurman RG. A new method to monitor Kupffer cell phagocytosis continuously in perfused rat liver Hepatology. 13: 567-574. DOI: 10.1002/Hep.1840130327 |
0.341 |
|
| 1988 |
Ganey PE, Sprugel KH, White SM, Wagner JG, Roth RA. Pulmonary hypertension due to monocrotaline pyrrole is reduced by moderate thrombocytopenia American Journal of Physiology - Heart and Circulatory Physiology. 255. PMID 3189578 DOI: 10.1152/Ajpheart.1988.255.5.H1165 |
0.338 |
|
| 1988 |
Roth RA, Ganey PE. Platelets and the puzzles of pulmonary pyrrolizidine poisoning Toxicology and Applied Pharmacology. 93: 463-471. PMID 3130680 DOI: 10.1016/0041-008X(88)90050-6 |
0.337 |
|
| 1987 |
Ganey PE, Roth RA. 5-Hydroxytryptamine and thromboxane in platelets from rats treated with monocrotaline pyrrole Toxicology and Applied Pharmacology. 88: 157-164. PMID 3564035 DOI: 10.1016/0041-008X(87)90001-9 |
0.326 |
|
| 1987 |
Roth RA, Ganey PE. Arachidonic acid metabolites and the mechanisms of monocrotaline pneumotoxicity American Review of Respiratory Disease. 136: 762-765. PMID 2820283 DOI: 10.1164/Ajrccm/136.3.762 |
0.33 |
|
| 1985 |
Ganey PE, Fink GD, Roth RA. The effect of dietary restriction and altered sodium intake on the cardiopulmonary toxicity of monocrotaline pyrrole Toxicology and Applied Pharmacology. 78: 55-62. PMID 2930913 DOI: 10.1016/0041-008X(85)90304-7 |
0.314 |
|
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