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Neil Segil - Publications

Affiliations: 
Genetic, Molecular, and Cell Biology University of Southern California, Los Angeles, CA, United States 
Area:
Cell Biology, Molecular Biology, Neuroscience Biology
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang X, Llamas J, Trecek T, Shi T, Tao L, Makmura W, Crump JG, Segil N, Gnedeva K. SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti. Proceedings of the National Academy of Sciences of the United States of America. 120: e2301301120. PMID 37585469 DOI: 10.1073/pnas.2301301120  0.727
2023 Nguyen JD, Llamas J, Shi T, Crump JG, Groves AK, Segil N. DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300839120. PMID 37549271 DOI: 10.1073/pnas.2300839120  0.55
2023 Sarkar A, Liu NQ, Magallanes J, Tassey J, Lee S, Shkhyan R, Lee Y, Lu J, Ouyang Y, Tang H, Bian F, Tao L, Segil N, Ernst J, Lyons K, et al. STAT3 promotes a youthful epigenetic state in articular chondrocytes. Aging Cell. e13773. PMID 36638270 DOI: 10.1111/acel.13773  0.567
2023 Shi T, Beaulieu MO, Saunders LM, Fabian P, Trapnell C, Segil N, Crump JG, Raible DW. Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. Elife. 12. PMID 36598134 DOI: 10.7554/eLife.82978  0.585
2022 Iyer AA, Hosamani I, Nguyen JD, Cai T, Singh S, McGovern MM, Beyer L, Zhang H, Jen HI, Yousaf R, Birol O, Sun JJ, Ray RS, Raphael Y, Segil N, et al. Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals. Elife. 11. PMID 36445327 DOI: 10.7554/eLife.79712  0.617
2022 Tao L, Segil N. CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing. Frontiers in Molecular Neuroscience. 15: 1013383. PMID 36311033 DOI: 10.3389/fnmol.2022.1013383  0.661
2022 Jen HI, Singh S, Tao L, Maunsell HR, Segil N, Groves AK. GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor. Scientific Reports. 12: 7793. PMID 35551236 DOI: 10.1038/s41598-022-11931-0  0.69
2021 Tao L, Yu HV, Llamas J, Trecek T, Wang X, Stojanova Z, Groves AK, Segil N. Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration. Developmental Cell. PMID 34331868 DOI: 10.1016/j.devcel.2021.07.003  0.734
2021 Yu HV, Tao L, Llamas J, Wang X, Nguyen JD, Trecek T, Segil N. POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34266958 DOI: 10.1073/pnas.2105137118  0.714
2021 Kastan N, Gnedeva K, Alisch T, Petelski AA, Huggins DJ, Chiaravalli J, Aharanov A, Shakked A, Tzahor E, Nagiel A, Segil N, Hudspeth AJ. Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nature Communications. 12: 3100. PMID 34035288 DOI: 10.1038/s41467-021-23395-3  0.425
2020 Menendez L, Trecek T, Gopalakrishnan S, Tao L, Markowitz AL, Yu HV, Wang X, Llamas J, Huang C, Lee J, Kalluri R, Ichida J, Segil N. Generation of inner ear hair cells by direct lineage conversion of primary somatic cells. Elife. 9. PMID 32602462 DOI: 10.7554/Elife.55249  0.755
2020 Gnedeva K, Wang X, McGovern MM, Barton M, Tao L, Trecek T, Monroe TO, Llamas J, Makmura W, Martin JF, Groves AK, Warchol M, Segil N. Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. Proceedings of the National Academy of Sciences of the United States of America. PMID 32482884 DOI: 10.1073/Pnas.2000175117  0.772
2020 Menendez L, Trecek T, Gopalakrishnan S, Tao L, Markowitz AL, Yu HV, Wang X, Llamas J, Huang C, Lee J, Kalluri R, Ichida J, Segil N. Author response: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells Elife. DOI: 10.7554/Elife.55249.Sa2  0.716
2019 Jen HI, Hill MC, Tao L, Sheng K, Cao W, Zhang H, Yu HV, Llamas J, Zong C, Martin JF, Segil N, Groves AK. Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1. Elife. 8. PMID 31033441 DOI: 10.7554/Elife.44328  0.79
2019 Jen H, Hill MC, Tao L, Sheng K, Cao W, Zhang H, Yu HV, Llamas J, Zong C, Martin JF, Segil N, Groves AK. Author response: Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1 Elife. DOI: 10.7554/Elife.44328.032  0.697
2018 Gnedeva K, Hudspeth AJ, Segil N. Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs. Journal of Visualized Experiments : Jove. PMID 29912206 DOI: 10.3791/57527  0.39
2017 Maletic-Savatic M, Semerci F, Choi WT, Bajic A, Thakkar A, Encinas JM, Depreux F, Segil N, Groves AK. Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance. Elife. 6. PMID 28699891 DOI: 10.7554/Elife.24660  0.653
2017 Teng CS, Yen HY, Barske L, Smith B, Llamas J, Segil N, Go J, Sanchez-Lara PA, Maxson RE, Crump JG. Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Scientific Reports. 7: 2497. PMID 28566723 DOI: 10.1038/S41598-017-02574-7  0.407
2017 Semerci F, Choi WT, Bajic A, Thakkar A, Encinas JM, Depreux F, Segil N, Groves AK, Maletic-Savatic M. Author response: Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance Elife. DOI: 10.7554/Elife.24660.016  0.465
2016 Basch ML, Brown RM, Jen HI, Semerci F, Depreux F, Edlund R, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife. 5. PMID 27966429 DOI: 10.7554/Elife.19921  0.682
2016 Stojanova ZP, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development (Cambridge, England). 143: 1632. PMID 27143757 DOI: 10.1242/dev.137976  0.499
2016 Rainey RN, Ng SY, Llamas J, van der Horst GT, Segil N. Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4758-70. PMID 27122034 DOI: 10.1523/Jneurosci.3890-15.2016  0.469
2016 Abdolazimi Y, Stojanova Z, Segil N. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development (Cambridge, England). 143: 841-50. PMID 26932672 DOI: 10.1242/Dev.129320  0.65
2016 Basch ML, Brown RM, Jen H, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK. Author response: Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates Elife. DOI: 10.7554/Elife.19921.015  0.46
2015 Stojanova ZP, Kwan T, Segil N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development (Cambridge, England). 142: 3529-36. PMID 26487780 DOI: 10.1242/Dev.126763  0.664
2015 Tao L, Segil N. Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear. Frontiers in Cellular Neuroscience. 9: 190. PMID 26052268 DOI: 10.3389/Fncel.2015.00190  0.714
2015 Nagtegaal AP, Rainey RN, van der Pluijm I, Brandt RM, van der Horst GT, Borst JG, Segil N. Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4280-6. PMID 25762674 DOI: 10.1523/Jneurosci.5063-14.2015  0.467
2013 Worman HJ, Segil N. Nucleocytoplasmic connections and deafness. The Journal of Clinical Investigation. 123: 553-5. PMID 23348730 DOI: 10.1172/Jci67454  0.41
2012 White PM, Stone JS, Groves AK, Segil N. EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Developmental Biology. 363: 191-200. PMID 22230616 DOI: 10.1016/J.Ydbio.2011.12.035  0.798
2011 Basch ML, Ohyama T, Segil N, Groves AK. Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8046-58. PMID 21632926 DOI: 10.1523/Jneurosci.6671-10.2011  0.708
2010 Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15044-51. PMID 21068310 DOI: 10.1523/Jneurosci.3547-10.2010  0.634
2010 Basch ML, Ohyama T, Segil N, Groves AK. Canonical Notch signaling is neither necessary nor sufficient for prosensory induction in the mouse cochlea Developmental Biology. 344: 484. DOI: 10.1016/J.Ydbio.2010.05.283  0.486
2009 Kwan T, White PM, Segil N. Development and regeneration of the inner ear. Annals of the New York Academy of Sciences. 1170: 28-33. PMID 19686102 DOI: 10.1111/J.1749-6632.2009.04484.X  0.796
2009 Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Developmental Cell. 16: 58-69. PMID 19154718 DOI: 10.1016/J.Devcel.2008.11.008  0.754
2008 Jayasena CS, Ohyama T, Segil N, Groves AK. Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development (Cambridge, England). 135: 2251-61. PMID 18495817 DOI: 10.1242/Dev.017905  0.561
2007 Raft S, Koundakjian EJ, Quinones H, Jayasena CS, Goodrich LV, Johnson JE, Segil N, Groves AK. Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development (Cambridge, England). 134: 4405-15. PMID 18039969 DOI: 10.1242/Dev.009118  0.702
2007 Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1434-44. PMID 17287518 DOI: 10.1523/Jneurosci.4956-06.2007  0.553
2006 White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. 441: 984-7. PMID 16791196 DOI: 10.1038/Nature04849  0.807
2006 Lee YS, Liu F, Segil N. A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development. Development (Cambridge, England). 133: 2817-26. PMID 16790479 DOI: 10.1242/Dev.02453  0.532
2006 Doetzlhofer A, White P, Lee YS, Groves A, Segil N. Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea. Brain Research. 1091: 282-8. PMID 16616734 DOI: 10.1016/J.Brainres.2006.02.071  0.799
2006 Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (Cambridge, England). 133: 1767-78. PMID 16571627 DOI: 10.1242/Dev.02347  0.388
2006 Basch ML, Ohyama T, Stanley P, Groves AK, Segil N. Development of the cochlea in the absence of all Notch signaling: A study of O-fucosyltransferase conditional knock out mice Developmental Biology. 295: 408. DOI: 10.1016/J.Ydbio.2006.04.254  0.494
2006 Jayasena CS, Ohyama T, Murtaugh C, Segil N, Groves AK. The role of notch signaling during early ear development Developmental Biology. 295: 408. DOI: 10.1016/J.Ydbio.2006.04.253  0.534
2004 Radde-Gallwitz K, Pan L, Gan L, Lin X, Segil N, Chen P. Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. The Journal of Comparative Neurology. 477: 412-21. PMID 15329890 DOI: 10.1002/Cne.20257  0.462
2004 Doetzlhofer A, White PM, Johnson JE, Segil N, Groves AK. In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Developmental Biology. 272: 432-47. PMID 15282159 DOI: 10.1016/J.Ydbio.2004.05.013  0.806
2003 Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P, Groves A, Segil N, Johnson JE. Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expression Patterns : Gep. 3: 389-95. PMID 12915300 DOI: 10.1016/S1567-133X(03)00089-9  0.746
2003 Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel MF, Segil N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nature Cell Biology. 5: 422-6. PMID 12717441 DOI: 10.1038/Ncb976  0.546
2002 Chen P, Johnson JE, Zoghbi HY, Segil N. The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development (Cambridge, England). 129: 2495-505. PMID 11973280  0.579
2001 Morishita H, Makishima T, Kaneko C, Lee YS, Segil N, Takahashi K, Kuraoka A, Nakagawa T, Nabekura J, Nakayama K, Nakayama KI. Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochemical and Biophysical Research Communications. 284: 142-9. PMID 11374883 DOI: 10.1006/Bbrc.2001.4939  0.346
1999 Chen P, Segil N. p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti Development. 126: 1581-1590. PMID 10079221  0.556
1996 Segil N, Guermah M, Hoffmann A, Roeder RG, Heintz N. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Genes & Development. 10: 2389-400. PMID 8843192 DOI: 10.1101/Gad.10.19.2389  0.383
1991 Roberts SB, Segil N, Heintz N. Differential phosphorylation of the transcription factor Oct1 during the cell cycle. Science (New York, N.Y.). 253: 1022-6. PMID 1887216 DOI: 10.1126/Science.1887216  0.434
1991 Segil N, Roberts SB, Heintz N. Cell-cycle-regulated phosphorylation of the transcription factor Oct-1. Cold Spring Harbor Symposia On Quantitative Biology. 56: 285-92. PMID 1819493 DOI: 10.1101/Sqb.1991.056.01.035  0.43
1991 Segil N, Roberts SB, Heintz N. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science (New York, N.Y.). 254: 1814-6. PMID 1684878 DOI: 10.1126/Science.1684878  0.381
1987 Grober MS, Bass AH, Burd G, Marchaterre MA, Segil N, Scholz K, Hodgson T. The nervus terminalis ganglion in Anguilla rostrata: an immunocytochemical and HRP histochemical analysis. Brain Research. 436: 148-52. PMID 3319052 DOI: 10.1016/0006-8993(87)91567-8  0.388
1986 Sassoon D, Segil N, Kelley D. Androgen-induced myogenesis and chondrogenesis in the larynx of Xenopus laevis. Developmental Biology. 113: 135-40. PMID 3943661 DOI: 10.1016/0012-1606(86)90115-6  0.373
1986 Bass AH, Segil N, Kelley DB. Androgen binding in the brain and electric organ of a mormyrid fish. Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology. 159: 535-44. PMID 3491207 DOI: 10.1007/Bf00604173  0.336
1984 Trenkner E, Smith D, Segil N. Is cerebellar granule cell migration regulated by an internal clock? Journal of Neuroscience. 4: 2850-2855. PMID 6502207 DOI: 10.1523/Jneurosci.04-11-02850.1984  0.481
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