Yuying Liang, Ph.D. - Publications

Affiliations: 
2000 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Genetics, Molecular Biology, Microbiology Biology

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liang Y. Pathogenicity and virulence of influenza. Virulence. 14: 2223057. PMID 37339323 DOI: 10.1080/21505594.2023.2223057  0.382
2022 Verma V, Dileepan M, Huang Q, Phan T, Hu WS, Ly H, Liang Y. Influenza A virus activates cellular Tropomyosin receptor kinase A (TrkA) signaling to promote viral replication and lung inflammation. Plos Pathogens. 18: e1010874. PMID 36121891 DOI: 10.1371/journal.ppat.1010874  0.378
2022 Di D, Huang Q, Ly H, Liang Y. Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line. Journal of Virology. e0075422. PMID 35913216 DOI: 10.1128/jvi.00754-22  0.392
2020 Huang Q, Liu X, Brisse M, Ly H, Liang Y. Effect of Strain Variations on Lassa Virus Z Protein-Mediated Human RIG-I Inhibition. Viruses. 12. PMID 32824946 DOI: 10.3390/V12090907  0.436
2020 Lan S, Shieh WJ, Huang Q, Zaki SR, Liang Y, Ly H. Virulent infection of outbred Hartley guinea pigs with recombinant Pichinde virus as a surrogate small animal model for human Lassa fever. Virulence. PMID 32799623 DOI: 10.1080/21505594.2020.1809328  0.414
2020 Shieh WJ, Lan S, Zaki SR, Ly H, Liang Y. Pichinde Virus Infection of Outbred Hartley Guinea Pigs as a Surrogate Animal Model for Human Lassa Fever: Histopathological and Immunohistochemical Analyses. Pathogens (Basel, Switzerland). 9. PMID 32708789 DOI: 10.3390/Pathogens9070579  0.38
2019 Shao J, Huang Q, Liu X, Di D, Dileepan M, Brisse M, Ly H, Liang Y. Biological characterization of conserved residues within the cytoplasmic tail of the Pichinde arenaviral glycoprotein subunit 2 (GP2). Journal of Virology. PMID 31462569 DOI: 10.1128/Jvi.01277-19  0.432
2018 Shao J, Huang Q, Liu X, Di D, Liang Y, Ly H. Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production. Journal of Virology. PMID 29669840 DOI: 10.1128/Jvi.00482-18  0.473
2018 Dhanwani R, Huang Q, Lan S, Zhou Y, Shao J, Liang Y, Ly H. Establishment of Bisegmented and Trisegmented Reverse Genetics Systems to Generate Recombinant Pichindé Viruses. Methods in Molecular Biology (Clifton, N.J.). 1604: 247-253. PMID 28986840 DOI: 10.1007/978-1-4939-6981-4_19  0.42
2018 Shao J, Liang Y, Ly H. Roles of Arenavirus Z Protein in Mediating Virion Budding, Viral Transcription-Inhibition and Interferon-Beta Suppression. Methods in Molecular Biology (Clifton, N.J.). 1604: 217-227. PMID 28986837 DOI: 10.1007/978-1-4939-6981-4_16  0.472
2018 Huang Q, Shao J, Liang Y, Ly H. Assays to Demonstrate the Roles of Arenaviral Nucleoproteins (NPs) in Viral RNA Synthesis and in Suppressing Type I Interferon. Methods in Molecular Biology (Clifton, N.J.). 1604: 189-200. PMID 28986834 DOI: 10.1007/978-1-4939-6981-4_13  0.47
2018 Qi X, Wang W, Dong H, Liang Y, Dong C, Ly H. Expression and X-Ray Structural Determination of the Nucleoprotein of Lassa Fever Virus. Methods in Molecular Biology (Clifton, N.J.). 1604: 179-188. PMID 28986833 DOI: 10.1007/978-1-4939-6981-4_12  0.317
2018 Shao J, Liu X, Liang Y, Ly H. Assays to Assess Arenaviral Glycoprotein Function. Methods in Molecular Biology (Clifton, N.J.). 1604: 169-178. PMID 28986832 DOI: 10.1007/978-1-4939-6981-4_11  0.472
2017 Dhanwani R, Ly H, Liang Y. Recombinant Tri-Segmented Pichinde Virus as a Novel Live Viral Vaccine Platform. Methods in Molecular Biology (Clifton, N.J.). 1581: 169-179. PMID 28374249 DOI: 10.1007/978-1-4939-6869-5_10  0.429
2017 Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, ... Liang Y, et al. Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host & Microbe. 21: 334-343. PMID 28279345 DOI: 10.1016/J.Chom.2017.02.007  0.369
2016 Shao J, Liu X, Ly H, Liang Y. Characterization of the glycoprotein stable signal peptide in mediating Pichinde viral replication and virulence. Journal of Virology. PMID 27630230 DOI: 10.1128/Jvi.01154-16  0.439
2016 Zhu L, Yuan C, Ding X, Xu S, Yang J, Liang Y, Zhu Q. PLC-γ1 is involved in the inflammatory response induced by influenza A virus H1N1 infection. Virology. 496: 131-137. PMID 27310357 DOI: 10.1016/J.Virol.2016.06.003  0.409
2015 Dhanwani R, Zhou Y, Huang Q, Verma V, Dileepan M, Ly H, Liang Y. A novel live Pichinde virus-based vaccine vector induces enhanced humoral and cellular immunity upon a booster dose. Journal of Virology. PMID 26676795 DOI: 10.1128/Jvi.02705-15  0.435
2015 Ly H, Liang Y. Immune evasion mechanisms of arenaviruses. Oncotarget. PMID 26595677 DOI: 10.18632/Oncotarget.6367  0.391
2015 Xing J, Chai Z, Ly H, Liang Y. Differential inhibition of macrophage activation by lymphocytic choriomeningitis virus and Pichinde virus is mediated by the Z protein N-terminal domain. Journal of Virology. PMID 26423945 DOI: 10.1128/Jvi.01674-15  0.439
2015 Shao J, Liang Y, Ly H. Human hemorrhagic Fever causing arenaviruses: molecular mechanisms contributing to virus virulence and disease pathogenesis. Pathogens (Basel, Switzerland). 4: 283-306. PMID 26011826 DOI: 10.3390/Pathogens4020283  0.418
2015 Huang Q, Shao J, Lan S, Zhou Y, Xing J, Dong C, Liang Y, Ly H. In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions. Journal of Virology. 89: 6595-607. PMID 25878103 DOI: 10.1128/Jvi.00009-15  0.496
2015 Xing J, Ly H, Liang Y. The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production. Journal of Virology. 89: 2944-55. PMID 25552708 DOI: 10.1128/Jvi.03349-14  0.432
2014 Wallat GD, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions. Plos One. 9: e87577. PMID 24516554 DOI: 10.1371/Journal.Pone.0087577  0.438
2014 Zhu L, Ly H, Liang Y. PLC-γ1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus. Journal of Virology. 88: 417-24. PMID 24155396 DOI: 10.1128/Jvi.02591-13  0.471
2014 McLay L, Liang Y, Ly H. Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections. The Journal of General Virology. 95: 1-15. PMID 24068704 DOI: 10.1099/Vir.0.057000-0  0.429
2014 Zhu L, Ly H, Liang Y. Correction for Zhu et al., PLC-γ1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus [Journal of Virology, 88, 1, (2014) 417-424] Doi:10.1128/JVI.02327-14 Journal of Virology. 88: 12931. DOI: 10.1128/Jvi.02327-14  0.366
2013 Jiang X, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression. The Journal of Biological Chemistry. 288: 16949-59. PMID 23615902 DOI: 10.1074/Jbc.M112.420521  0.388
2013 McLay L, Lan S, Ansari A, Liang Y, Ly H. Identification of virulence determinants within the L genomic segment of the pichinde arenavirus. Journal of Virology. 87: 6635-43. PMID 23552411 DOI: 10.1128/Jvi.00044-13  0.412
2013 McLay L, Ansari A, Liang Y, Ly H. Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever. Antiviral Research. 97: 81-92. PMID 23261843 DOI: 10.1016/J.Antiviral.2012.12.003  0.467
2012 Kumar N, Wang J, Lan S, Danzy S, McLay Schelde L, Seladi-Schulman J, Ly H, Liang Y. Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus. Virology. 433: 97-103. PMID 22877842 DOI: 10.1016/J.Virol.2012.07.009  0.464
2012 Wang J, Danzy S, Kumar N, Ly H, Liang Y. Biological roles and functional mechanisms of arenavirus Z protein in viral replication. Journal of Virology. 86: 9794-801. PMID 22761375 DOI: 10.1128/Jvi.00385-12  0.506
2012 Liang Y, Danzy S, Dao LD, Parslow TG, Liang Y. Mutational analyses of the influenza A virus polymerase subunit PA reveal distinct functions related and unrelated to RNA polymerase activity. Plos One. 7: e29485. PMID 22238617 DOI: 10.1371/Journal.Pone.0029485  0.474
2011 Kumar N, Sharma NR, Ly H, Parslow TG, Liang Y. Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses. Antimicrobial Agents and Chemotherapy. 55: 5553-9. PMID 21930873 DOI: 10.1128/Aac.00725-11  0.434
2011 Kumar N, Liang Y, Parslow TG, Liang Y. Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. Journal of Virology. 85: 2818-27. PMID 21209112 DOI: 10.1128/Jvi.01969-10  0.46
2010 Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD, Ly H, Liang Y, Dong C. Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature. 468: 779-83. PMID 21085117 DOI: 10.1038/Nature09605  0.421
2010 Bhosle S, Suppiah S, Molinaro R, Liang Y, Arnold R, Diehl W, Makarova N, Blackwell J, Petros J, Liotta D, Hunter E, Ly H. Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. Journal of Virology. 84: 6288-96. PMID 20410264 DOI: 10.1128/Jvi.00274-10  0.311
2009 Liang Y, Lan S, Ly H. Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers. Annals of the New York Academy of Sciences. 1171: E65-74. PMID 19751405 DOI: 10.1111/J.1749-6632.2009.05051.X  0.42
2009 Lan S, McLay Schelde L, Wang J, Kumar N, Ly H, Liang Y. Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers. Journal of Virology. 83: 6357-62. PMID 19386714 DOI: 10.1128/Jvi.00019-09  0.488
2008 Kumar N, Xin ZT, Liang Y, Ly H, Liang Y. NF-kappaB signaling differentially regulates influenza virus RNA synthesis. Journal of Virology. 82: 9880-9. PMID 18701591 DOI: 10.1128/Jvi.00909-08  0.492
2008 Lan S, McLay L, Aronson J, Ly H, Liang Y. Genome comparison of virulent and avirulent strains of the Pichinde arenavirus. Archives of Virology. 153: 1241-50. PMID 18506572 DOI: 10.1007/S00705-008-0101-2  0.498
2008 Liang Y, Huang T, Ly H, Parslow TG, Liang Y. Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments. Journal of Virology. 82: 229-36. PMID 17959657 DOI: 10.1128/Jvi.01541-07  0.446
2007 Deng H, Liang Y, Sun R. Regulation of KSHV Lytic Gene Expression Current Topics in Microbiology and Immunology. 312: 157-183. PMID 17089797 DOI: 10.1007/978-3-540-34344-8_6  0.355
2006 Regan JF, Liang Y, Parslow TG. Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA. Journal of Virology. 80: 252-61. PMID 16352550 DOI: 10.1128/Jvi.80.1.252-261.2006  0.521
2005 Liang Y, Hong Y, Parslow TG. cis-Acting packaging signals in the influenza virus PB1, PB2, and PA genomic RNA segments. Journal of Virology. 79: 10348-55. PMID 16051827 DOI: 10.1128/Jvi.79.16.10348-10355.2005  0.439
2004 Liang Y, Ganem D. RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA. Journal of Virology. 78: 6818-26. PMID 15194757 DOI: 10.1128/Jvi.78.13.6818-6826.2004  0.351
2003 Liang Y, Ganem D. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 8490-5. PMID 12832621 DOI: 10.1073/Pnas.1432843100  0.431
2003 Bechtel JT, Liang Y, Hvidding J, Ganem D. Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. Journal of Virology. 77: 6474-81. PMID 12743304 DOI: 10.1128/Jvi.77.11.6474-6481.2003  0.352
2002 Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes & Development. 16: 1977-89. PMID 12154127 DOI: 10.1101/Gad.996502  0.334
2002 Wang X, Liang Y, Gillam S. Rescue of rubella virus replication-defective mutants using vaccinia virus recombinant expressing rubella virus nonstructural proteins. Virus Research. 86: 111-22. PMID 12076835 DOI: 10.1016/S0168-1702(02)00077-1  0.637
2001 Liang Y, Gillam S. Rubella virus RNA replication is cis-preferential and synthesis of negative- and positive-strand RNAs is regulated by the processing of nonstructural protein. Virology. 282: 307-19. PMID 11289813 DOI: 10.1006/Viro.2001.0862  0.591
2000 Liang Y, Yao J, Gillam S. Rubella virus nonstructural protein protease domains involved in trans- and cis-cleavage activities. Journal of Virology. 74: 5412-23. PMID 10823845 DOI: 10.1128/Jvi.74.12.5412-5423.2000  0.601
2000 Liang Y, Gillam S. Mutational analysis of the rubella virus nonstructural polyprotein and its cleavage products in virus replication and RNA synthesis. Journal of Virology. 74: 5133-41. PMID 10799588 DOI: 10.1128/Jvi.74.11.5133-5141.2000  0.657
1998 Yao J, Yang D, Chong P, Hwang D, Liang Y, Gillam S. Proteolytic processing of rubella virus nonstructural proteins. Virology. 246: 74-82. PMID 9656995 DOI: 10.1006/Viro.1998.9179  0.63
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