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Jeffrey A. Loeb, MD/PHD - Publications

Affiliations: 
1998-2013 Center for Molecular Medicine & Genetics, Dept. of Neurology Wayne State University School of Medicine, Detroit, MI, United States 
 2013- Neurology University of Illinois at Chicago, Chicago, IL, United States 
Area:
Epilepsy, Neuregulin
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Year Citation  Score
2020 Kirchner A, Bagla S, Dachet F, Loeb JA. DUSP4 appears to be a highly localized endogenous inhibitor of epileptic signaling in human neocortex. Neurobiology of Disease. 105073. PMID 32890776 DOI: 10.1016/J.Nbd.2020.105073  0.705
2020 Schram S, Loeb JA, Song F. Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment. Journal of Neuroinflammation. 17: 175. PMID 32505190 DOI: 10.1186/S12974-020-01849-7  0.308
2020 Herrick JA, Bustos JA, Clapham P, Garcia HH, Loeb JA, For The Cysticercosis Working Group In Peru. Unique Characteristics of Epilepsy Development in Neurocysticercosis. The American Journal of Tropical Medicine and Hygiene. PMID 32431269 DOI: 10.4269/Ajtmh.19-0485  0.322
2019 Kirchner A, Dachet F, Loeb JA. Identifying targets for preventing epilepsy using systems biology of the human brain. Neuropharmacology. 107757. PMID 31493467 DOI: 10.1016/J.Neuropharm.2019.107757  0.374
2018 Maharathi B, Wlodarski R, Bagla S, Asano E, Hua J, Patton J, Loeb JA. Interictal spike connectivity in human epileptic neocortex. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 130: 270-279. PMID 30605889 DOI: 10.1016/J.Clinph.2018.11.025  0.688
2018 Keren-Aviram G, Dachet F, Bagla S, Balan K, Loeb JA, Dratz EA. Proteomic analysis of human epileptic neocortex predicts vascular and glial changes in epileptic regions. Plos One. 13: e0195639. PMID 29634780 DOI: 10.1371/Journal.Pone.0195639  0.698
2017 Liu J, Allender E, Wang J, Simpson EH, Loeb JA, Song F. Slowing disease progression in the SOD1 mouse model of ALS by blocking neuregulin-induced microglial activation. Neurobiology of Disease. 111: 118-126. PMID 29278738 DOI: 10.1016/J.Nbd.2017.12.012  0.541
2017 Wu HC, Dachet F, Ghoddoussi F, Bagla S, Fuerst D, Stanley JA, Galloway MP, Loeb JA. Altered metabolomic-genomic signature: A potential noninvasive biomarker of epilepsy. Epilepsia. PMID 28714074 DOI: 10.1111/Epi.13848  0.764
2017 Wang J, Song F, Loeb JA. Neuregulin1 Fine-tunes Pre-, Post-, and Peri-Synaptic Neuromuscular Junction Development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 28245533 DOI: 10.1002/Dvdy.24494  0.562
2015 Mittal S, Barkmeier D, Hua J, Pai DS, Fuerst D, Basha M, Loeb JA, Shah AK. Intracranial EEG analysis in tumor-related epilepsy: Evidence of distant epileptic abnormalities. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. PMID 26493495 DOI: 10.1016/J.Clinph.2015.06.028  0.74
2015 Wang J, Hmadcha A, Zakarian V, Song F, Loeb JA. Rapid transient isoform-specific neuregulin1 transcription in motor neurons is regulated by neurotrophic factors and axon-target interactions. Molecular and Cellular Neurosciences. 68: 73-81. PMID 25913151 DOI: 10.1016/J.Mcn.2015.04.003  0.581
2015 Nash TE, Mahanty S, Loeb JA, Theodore WH, Friedman A, Sander JW, Singh G, Cavalheiro E, Del Brutto OH, Takayanagui OM, Fleury A, Verastegui M, Preux PM, Montano S, Pretell EJ, et al. Neurocysticercosis: A natural human model of epileptogenesis. Epilepsia. 56: 177-83. PMID 25534640 DOI: 10.1111/Epi.12849  0.316
2015 Dachet F, Bagla S, Keren-Aviram G, Morton A, Balan K, Saadat L, Valyi-Nagy T, Kupsky W, Song F, Dratz E, Loeb JA. Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering. Brain : a Journal of Neurology. 138: 356-70. PMID 25516101 DOI: 10.1093/Brain/Awu350  0.704
2014 Rossignol E, Kobow K, Simonato M, Loeb JA, Grisar T, Gilby KL, Vinet J, Kadam SD, Becker AJ. WONOEP appraisal: new genetic approaches to study epilepsy. Epilepsia. 55: 1170-86. PMID 24965021 DOI: 10.1111/Epi.12692  0.374
2014 Song F, Chiang P, Ravits J, Loeb JA. Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 77-83. PMID 24229388 DOI: 10.3109/21678421.2013.853802  0.336
2013 Mittal S, Shah AK, Barkmeier DT, Loeb JA. Systems biology of human epilepsy applied to patients with brain tumors. Epilepsia. 54: 35-9. PMID 24328870 DOI: 10.1111/Epi.12441  0.764
2013 Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE. Epilepsy therapy development: technical and methodologic issues in studies with animal models. Epilepsia. 54: 13-23. PMID 23909850 DOI: 10.1111/Epi.12295  0.336
2013 Song F, Bandara M, Deol H, Loeb JA, Benjamins J, Lisak RP. Complexity of trophic factor signaling in experimental autoimmune encephalomyelitis: differential expression of neurotrophic and gliotrophic factors. Journal of Neuroimmunology. 262: 11-8. PMID 23763772 DOI: 10.1016/J.Jneuroim.2013.05.012  0.318
2013 Jeng D, Ma Z, Barrett JW, McFadden G, Loeb JA, Essani K. The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells. Journal of Virology. 87: 3018-26. PMID 23269801 DOI: 10.1128/Jvi.02112-12  0.56
2013 Boutros N, Perrine S, Senador D, Barkmeier D, Loeb J. A novel rat model of ADHD associated with isolated epileptiform discharges Epilepsy & Behavior. 28: 326-327. DOI: 10.1016/J.Yebeh.2012.04.090  0.717
2013 Wang J, Ma Z, Loeb JA. Cell-Specific Targeting of Fusion Proteins through Heparin Binding Fusion Protein Technologies For Biopharmaceuticals: Applications and Challenges. 413-427. DOI: 10.1002/9781118354599.ch27  0.485
2012 Beaumont TL, Yao B, Shah A, Kapatos G, Loeb JA. Layer-specific CREB target gene induction in human neocortical epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14389-401. PMID 23055509 DOI: 10.1523/Jneurosci.3408-12.2012  0.774
2012 Lipovich L, Dachet F, Cai J, Bagla S, Balan K, Jia H, Loeb JA. Activity-dependent human brain coding/noncoding gene regulatory networks. Genetics. 192: 1133-48. PMID 22960213 DOI: 10.1534/Genetics.112.145128  0.706
2012 Barkmeier DT, Senador D, Leclercq K, Pai D, Hua J, Boutros NN, Kaminski RM, Loeb JA. Electrical, molecular and behavioral effects of interictal spiking in the rat. Neurobiology of Disease. 47: 92-101. PMID 22472188 DOI: 10.1016/J.Nbd.2012.03.026  0.768
2012 Yadav R, Shah AK, Loeb JA, Swamy MN, Agarwal R. Morphology-based automatic seizure detector for intracerebral EEG recordings. Ieee Transactions On Bio-Medical Engineering. 59: 1871-81. PMID 22434792 DOI: 10.1109/Tbme.2012.2190601  0.319
2012 Song F, Chiang P, Wang J, Ravits J, Loeb JA. Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis. Journal of Neuropathology and Experimental Neurology. 71: 104-15. PMID 22249457 DOI: 10.1097/Nen.0B013E3182423C43  0.605
2012 Barkmeier DT, Shah AK, Flanagan D, Atkinson MD, Agarwal R, Fuerst DR, Jafari-Khouzani K, Loeb JA. High inter-reviewer variability of spike detection on intracranial EEG addressed by an automated multi-channel algorithm. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 123: 1088-95. PMID 22033028 DOI: 10.1016/J.Clinph.2011.09.023  0.745
2011 Ma Z, Wang J, Song F, Loeb JA. Critical period of axoglial signaling between neuregulin-1 and brain-derived neurotrophic factor required for early Schwann cell survival and differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9630-40. PMID 21715628 DOI: 10.1523/Jneurosci.1659-11.2011  0.7
2011 Loeb JA. Identifying targets for preventing epilepsy using systems biology. Neuroscience Letters. 497: 205-12. PMID 21382442 DOI: 10.1016/J.Neulet.2011.02.041  0.368
2011 Calvo M, Zhu N, Grist J, Ma Z, Loeb JA, Bennett DL. Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway. Glia. 59: 554-68. PMID 21319222 DOI: 10.1002/Glia.21124  0.55
2010 de Guzman RC, Loeb JA, VandeVord PJ. Electrospinning of matrigel to deposit a basal lamina-like nanofiber surface. Journal of Biomaterials Science. Polymer Edition. 21: 1081-101. PMID 20507710 DOI: 10.1163/092050609X12457428936116  0.305
2010 Calvo M, Zhu N, Tsantoulas C, Ma Z, Grist J, Loeb JA, Bennett DL. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5437-50. PMID 20392965 DOI: 10.1523/Jneurosci.5169-09.2010  0.568
2009 Barkmeier DT, Loeb JA. An animal model to study the clinical significance of interictal spiking. Clinical Eeg and Neuroscience. 40: 234-8. PMID 19780344 DOI: 10.1177/155005940904000405  0.756
2009 Ma Z, Li Q, An H, Pankonin MS, Wang J, Loeb JA. Targeting human epidermal growth factor receptor signaling with the neuregulin's heparin-binding domain. The Journal of Biological Chemistry. 284: 32108-15. PMID 19717564 DOI: 10.1074/Jbc.M109.032714  0.752
2009 Esper RM, Loeb JA. Neurotrophins induce neuregulin release through protein kinase Cdelta activation. The Journal of Biological Chemistry. 284: 26251-60. PMID 19648576 DOI: 10.1074/Jbc.M109.002915  0.792
2009 Pankonin MS, Sohi J, Kamholz J, Loeb JA. Differential distribution of neuregulin in human brain and spinal fluid. Brain Research. 1258: 1-11. PMID 19150438 DOI: 10.1016/J.Brainres.2008.12.047  0.773
2009 Loeb JA, Beaumont TL. What goes in is what comes out: How to design and implement a successful microarray experiment Bioinformatics For Systems Biology. 209-225. DOI: 10.1007/978-1-59745-440-7_12  0.67
2008 Rakhade SN, Loeb JA. Focal reduction of neuronal glutamate transporters in human neocortical epilepsy. Epilepsia. 49: 226-36. PMID 17868051 DOI: 10.1111/J.1528-1167.2007.01310.X  0.773
2007 Rakhade SN, Shah AK, Agarwal R, Yao B, Asano E, Loeb JA. Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy. Epilepsia. 48: 86-95. PMID 17910586 DOI: 10.1111/J.1528-1167.2007.01294.X  0.781
2007 Loeb JA. Neuroprotection and repair by neurotrophic and gliotrophic factors in multiple sclerosis. Neurology. 68: S38-42; discussion S. PMID 17548567 DOI: 10.1212/01.Wnl.0000275231.97764.43  0.337
2006 Shah AK, Agarwal R, Carhuapoma JR, Loeb JA. Compressed EEG pattern analysis for critically ill neurological-neurosurgical patients. Neurocritical Care. 5: 124-33. PMID 17099259 DOI: 10.1385/Ncc:5:2:124  0.322
2006 Hapner SJ, Nielsen KM, Chaverra M, Esper RM, Loeb JA, Lefcort F. NT-3 and CNTF exert dose-dependent, pleiotropic effects on cells in the immature dorsal root ganglion: neuregulin-mediated proliferation of progenitor cells and neuronal differentiation. Developmental Biology. 297: 182-97. PMID 16784738 DOI: 10.1016/J.Ydbio.2006.05.007  0.784
2006 Esper RM, Pankonin MS, Loeb JA. Neuregulins: versatile growth and differentiation factors in nervous system development and human disease. Brain Research Reviews. 51: 161-75. PMID 16412517 DOI: 10.1016/J.Brainresrev.2005.11.006  0.761
2005 Rakhade SN, Yao B, Ahmed S, Asano E, Beaumont TL, Shah AK, Draghici S, Krauss R, Chugani HT, Sood S, Loeb JA. A common pattern of persistent gene activation in human neocortical epileptic foci. Annals of Neurology. 58: 736-47. PMID 16240350 DOI: 10.1002/Ana.20633  0.785
2005 Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, Salzer JL. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron. 47: 681-94. PMID 16129398 DOI: 10.1016/J.Neuron.2005.08.017  0.755
2005 Pankonin MS, Gallagher JT, Loeb JA. Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling. The Journal of Biological Chemistry. 280: 383-8. PMID 15528194 DOI: 10.1074/Jbc.M402645200  0.767
2004 Li Q, Ahmed S, Loeb JA. Development of an autocrine neuregulin signaling loop with malignant transformation of human breast epithelial cells. Cancer Research. 64: 7078-85. PMID 15466203 DOI: 10.1158/0008-5472.Can-04-1152  0.516
2004 Li Q, Esper RM, Loeb JA. Synergistic effects of neuregulin and agrin on muscle acetylcholine receptor expression. Molecular and Cellular Neurosciences. 26: 558-69. PMID 15276157 DOI: 10.1016/J.Mcn.2004.04.009  0.772
2004 Yao B, Rakhade SN, Li Q, Ahmed S, Krauss R, Draghici S, Loeb JA. Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cells. Bmc Bioinformatics. 5: 99. PMID 15272935 DOI: 10.1186/1471-2105-5-99  0.76
2004 Esper RM, Loeb JA. Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6218-27. PMID 15240814 DOI: 10.1523/Jneurosci.1692-04.2004  0.785
2004 Nash TE, Del Brutto OH, Butman JA, Corona T, Delgado-Escueta A, Duron RM, Evans CA, Gilman RH, Gonzalez AE, Loeb JA, Medina MT, Pietsch-Escueta S, Pretell EJ, Takayanagui OM, Theodore W, et al. Calcific neurocysticercosis and epileptogenesis. Neurology. 62: 1934-8. PMID 15184592 DOI: 10.1212/01.Wnl.0000129481.12067.06  0.324
2003 Loeb JA. Neuregulin: an activity-dependent synaptic modulator at the neuromuscular junction. Journal of Neurocytology. 32: 649-64. PMID 15034258 DOI: 10.1023/B:Neur.0000020640.84708.35  0.306
2002 Loeb JA, Hmadcha A, Fischbach GD, Land SJ, Zakarian VL. Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2206-14. PMID 11896160 DOI: 10.1523/Jneurosci.22-06-02206.2002  0.59
2001 Li Q, Loeb JA. Neuregulin-heparan-sulfate proteoglycan interactions produce sustained erbB receptor activation required for the induction of acetylcholine receptors in muscle. The Journal of Biological Chemistry. 276: 38068-75. PMID 11502740 DOI: 10.1074/Jbc.M104485200  0.512
1999 Ford BD, Loeb JA, Fischbach GD. Neuregulin stimulates DNA synthesis in embryonic chick heart cells. Developmental Biology. 214: 139-50. PMID 10491263 DOI: 10.1006/Dbio.1999.9394  0.586
1999 Loeb JA, Khurana TS, Robbins JT, Yee AG, Fischbach GD. Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development. Development (Cambridge, England). 126: 781-91. PMID 9895325  0.569
1998 Loeb JA, Susanto ET, Fischbach GD. The neuregulin precursor proARIA is processed to ARIA after expression on the cell surface by a protein kinase C-enhanced mechanism. Molecular and Cellular Neurosciences. 11: 77-91. PMID 9608535 DOI: 10.1006/Mcne.1998.0676  0.604
1997 Loeb JA, Fischbach GD. Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1416-24. PMID 9006983 DOI: 10.1523/Jneurosci.17-04-01416.1997  0.627
1996 Rosen KM, Sandrock AW, Goodearl AD, Loeb JA, Fischbach GD. The role of neuregulin (ARIA) at the neuromuscular junction. Cold Spring Harbor Symposia On Quantitative Biology. 61: 427-34. PMID 9246471 DOI: 10.1101/Sqb.1996.061.01.045  0.491
1995 Loeb JA, Fischbach GD. ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain. The Journal of Cell Biology. 130: 127-35. PMID 7540614 DOI: 10.1083/Jcb.130.1.127  0.598
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