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Stephen J. Crocker - Publications

Affiliations: 
Neuroscience University of Connecticut School of Medicine, Farmington, CT, United States 
Area:
Myelin, Glial Biology, Neuroinflammation
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sutter PA, Willis CM, Menoret A, Nicaise AM, Sacino A, Sikkema AH, Jellison ER, Win KK, Han DK, Church W, Baron W, Vella AT, Crocker SJ. Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses. Proceedings of the National Academy of Sciences of the United States of America. 121: e2306816121. PMID 38266047 DOI: 10.1073/pnas.2306816121  0.372
2023 Sutter PA, Ménoret A, Jellison ER, Nicaise AM, Bradbury AM, Vella AT, Bongarzone ER, Crocker SJ. CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy. The Journal of Experimental Medicine. 220. PMID 37310382 DOI: 10.1084/jem.20221862  0.76
2023 Sutter PA, Willis CM, Menoret A, Nicaise AM, Sacino A, Sikkema AH, Jellison E, Win KK, Han DK, Church W, Baron W, Vella AT, Crocker SJ. Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responses. Biorxiv : the Preprint Server For Biology. PMID 36824834 DOI: 10.1101/2023.02.17.529003  0.818
2022 Sutter PA, Crocker SJ. Glia as antigen-presenting cells in the central nervous system. Current Opinion in Neurobiology. 77: 102646. PMID 36371828 DOI: 10.1016/j.conb.2022.102646  0.332
2022 Ramasamy R, Hardy CC, Crocker SJ, Smith PP. Cuprizone-mediated demyelination reversibly degrades voiding behavior in mice while sparing brainstem reflex. Journal of Neuroscience Research. PMID 35596557 DOI: 10.1002/jnr.25065  0.308
2022 Rouillard ME, Hu J, Sutter PA, Kim HW, Huang JK, Crocker SJ. The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination. Frontiers in Cellular Neuroscience. 16: 833186. PMID 35573828 DOI: 10.3389/fncel.2022.833186  0.336
2021 Rouillard ME, Sutter PA, Durham OR, Willis CM, Crocker SJ. Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging. Aging and Disease. 12: 1462-1475. PMID 34527422 DOI: 10.14336/AD.2021.0608  0.772
2020 Nicaise AM, Willis CM, Crocker SJ, Pluchino S. Stem Cells of the Aging Brain. Frontiers in Aging Neuroscience. 12: 247. PMID 32848716 DOI: 10.3389/Fnagi.2020.00247  0.788
2020 Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ. Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Scientific Reports. 10: 828. PMID 31964978 DOI: 10.1038/S41598-020-57663-X  0.789
2020 Willis CM, Sutter P, Rouillard M, Crocker SJ. The Effects of IL-1β on Astrocytes are Conveyed by Extracellular Vesicles and Influenced by Age. Neurochemical Research. PMID 31900795 DOI: 10.1007/S11064-019-02937-8  0.752
2019 Werneburg S, Jung J, Kunjamma RB, Ha SK, Luciano NJ, Willis CM, Gao G, Biscola NP, Havton LA, Crocker SJ, Popko B, Reich DS, Schafer DP. Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease. Immunity. PMID 31883839 DOI: 10.1016/J.Immuni.2019.12.004  0.786
2019 Knight BE, Kozlowski N, Havelin J, King T, Crocker SJ, Young EE, Baumbauer KM. TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms. Frontiers in Molecular Neuroscience. 12: 220. PMID 31616247 DOI: 10.3389/Fnmol.2019.00220  0.375
2019 Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. Systemic TLR2 tolerance enhances central nervous system remyelination. Journal of Neuroinflammation. 16: 158. PMID 31351476 DOI: 10.1186/S12974-019-1540-2  0.761
2019 Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31068461 DOI: 10.1073/Pnas.1816911116  0.802
2019 Nicaise AM, Wagstaff LJ, Willis CM, Paisie C, Chandok H, Robson P, Fossati V, Williams A, Crocker SJ. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30910981 DOI: 10.1073/Pnas.1818348116  0.818
2019 Knight B, Glidden N, King T, Crocker S, Young E, Baumbauer K. (239) Tissue Inhibitor of Matrix Metalloproteinase-1 Attenuates the Onset of Hypersensitivity Using a Model of Cutaneous Inflammation The Journal of Pain. 20: S34. DOI: 10.1016/J.Jpain.2019.01.160  0.375
2018 Nicaise AM, Johnson KM, Willis CM, Guzzo RM, Crocker SJ. TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling. Molecular Neurobiology. PMID 30121936 DOI: 10.1007/S12035-018-1310-7  0.783
2018 Knight B, Yasko J, Crocker S, Young E, Baumbauer K. The role of cell-specific TIMP-1 modulating mechanical hypersensitivity in a subcutaneous inflammatory model The Journal of Pain. 19: S7. DOI: 10.1016/J.Jpain.2017.12.036  0.361
2017 Willis CM, Ménoret A, Jellison ER, Nicaise AM, Vella AT, Crocker SJ. A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma. Frontiers in Neuroscience. 11: 335. PMID 28663721 DOI: 10.3389/Fnins.2017.00335  0.811
2017 Knight B, Yasko J, Crocker S, Young E, Baumbauer K. (113) TIMP-1 regulates the persistence of inflammatory hypersensitivity The Journal of Pain. 18: S5. DOI: 10.1016/J.Jpain.2017.02.019  0.305
2016 Knight B, Young E, Crocker S, Baumbauer K. (356) Identification of a heterogeneous population of satellite glial cells in the mouse dorsal root ganglion. The Journal of Pain : Official Journal of the American Pain Society. 17: S64. PMID 28162598 DOI: 10.1016/J.Jpain.2016.01.263  0.315
2016 Yasko J, Kiprono T, Knight B, Willis C, Nicaise A, Young E, Crocker S, Baumbauer K. (350) Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) regulates mechanical sensitivity following cutaneous inflammation. The Journal of Pain : Official Journal of the American Pain Society. 17: S63. PMID 28162595 DOI: 10.1016/J.Jpain.2016.01.257  0.77
2016 Nicaise AM, Banda E, Guzzo RM, Russomanno K, Castro-Borrero W, Willis CM, Johnson KM, Lo AC, Crocker SJ. iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response. Experimental Neurology. PMID 27865736 DOI: 10.1016/J.Expneurol.2016.11.012  0.791
2016 Nicaise AM, Bongarzone ER, Crocker SJ. A microglial hypothesis of globoid cell leukodystrophy pathology. Journal of Neuroscience Research. 94: 1049-61. PMID 27638591 DOI: 10.1002/Jnr.23773  0.781
2015 Johnson KM, Crocker SJ. TIMP-1 couples RhoK activation to IL-1β-induced astrocyte responses. Neuroscience Letters. 609: 165-170. PMID 26484505 DOI: 10.1016/J.Neulet.2015.10.038  0.786
2015 Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, Vella AT. Transition from Identity to Bioactivity-Guided Proteomics for Biomarker Discovery with Focus on the PF2D Platform. Proteomics. Clinical Applications. PMID 26201056 DOI: 10.1002/Prca.201500029  0.331
2015 Johnson KM, Milner R, Crocker SJ. Extracellular matrix composition determines astrocyte responses to mechanical and inflammatory stimuli. Neuroscience Letters. 600: 104-9. PMID 26067407 DOI: 10.1016/J.Neulet.2015.06.013  0.805
2014 Claycomb KI, Johnson KM, Bongarzone ER, Crocker SJ. An in vitro model for the study of cellular pathophysiology in globoid cell leukodystrophy. Journal of Visualized Experiments : Jove. e51903. PMID 25350151 DOI: 10.3791/51903  0.781
2014 Claycomb KI, Winokur PN, Johnson KM, Nicaise AM, Giampetruzzi AW, Sacino AV, Snyder EY, Barbarese E, Bongarzone ER, Crocker SJ. Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. Journal of Neuropathology and Experimental Neurology. 73: 964-74. PMID 25192051 DOI: 10.1097/Nen.0000000000000117  0.787
2014 Wang X, Kimbrel EA, Ijichi K, Paul D, Lazorchak AS, Chu J, Kouris NA, Yavanian GJ, Lu SJ, Pachter JS, Crocker SJ, Lanza R, Xu RH. Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis. Stem Cell Reports. 3: 115-30. PMID 25068126 DOI: 10.1016/J.Stemcr.2014.04.020  0.378
2014 Smith BR, Santos MB, Marshall MS, Cantuti-Castelvetri L, Lopez-Rosas A, Li G, van Breemen R, Claycomb KI, Gallea JI, Celej MS, Crocker SJ, Givogri MI, Bongarzone ER. Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease. The Journal of Pathology. 232: 509-21. PMID 24415155 DOI: 10.1002/Path.4328  0.791
2013 Claycomb KI, Johnson KM, Winokur PN, Sacino AV, Crocker SJ. Astrocyte regulation of CNS inflammation and remyelination. Brain Sciences. 3: 1109-27. PMID 24961523 DOI: 10.3390/Brainsci3031109  0.796
2013 Ijichi K, Brown GD, Moore CS, Lee JP, Winokur PN, Pagarigan R, Snyder EY, Bongarzone ER, Crocker SJ. MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology. Glia. 61: 765-77. PMID 23404611 DOI: 10.1002/Glia.22471  0.776
2012 Zhan H, Moore CS, Chen B, Zhou X, Ma XM, Ijichi K, Bennett MV, Li XJ, Crocker SJ, Wang ZW. Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. Plos One. 7: e39489. PMID 22768083 DOI: 10.1371/Journal.Pone.0039489  0.719
2012 Moore CS, Crocker SJ. An alternate perspective on the roles of TIMPs and MMPs in pathology. The American Journal of Pathology. 180: 12-6. PMID 22033229 DOI: 10.1016/J.Ajpath.2011.09.008  0.731
2011 Welser-Alves JV, Crocker SJ, Milner R. A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli. Journal of Neuroinflammation. 8: 61. PMID 21631912 DOI: 10.1186/1742-2094-8-61  0.441
2011 Moore CS, Milner R, Nishiyama A, Frausto RF, Serwanski DR, Pagarigan RR, Whitton JL, Miller RH, Crocker SJ. Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6247-54. PMID 21508247 DOI: 10.1523/Jneurosci.5474-10.2011  0.812
2011 Tsueng G, Tabor-Godwin JM, Gopal A, Ruller CM, Deline S, An N, Frausto RF, Milner R, Crocker SJ, Whitton JL, Feuer R. Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells. Journal of Virology. 85: 5718-32. PMID 21471247 DOI: 10.1128/Jvi.02261-10  0.576
2011 Crocker SJ, Bajpai R, Moore CS, Frausto RF, Brown GD, Pagarigan RR, Whitton JL, Terskikh AV. Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination. Neuropathology and Applied Neurobiology. 37: 643-53. PMID 21276029 DOI: 10.1111/J.1365-2990.2011.01165.X  0.791
2011 Moore CS, Abdullah SL, Brown A, Arulpragasam A, Crocker SJ. How factors secreted from astrocytes impact myelin repair. Journal of Neuroscience Research. 89: 13-21. PMID 20857501 DOI: 10.1002/Jnr.22482  0.776
2009 Feuer R, Ruller CM, An N, Tabor-Godwin JM, Rhoades RE, Maciejewski S, Pagarigan RR, Cornell CT, Crocker SJ, Kiosses WB, Pham-Mitchell N, Campbell IL, Whitton JL. Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period. Journal of Virology. 83: 9356-69. PMID 19570873 DOI: 10.1128/Jvi.02382-07  0.644
2009 Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ. Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis. Autophagy. 5: 152-8. PMID 19066443 DOI: 10.4161/Auto.5.2.7348  0.799
2009 Grant RJ, Sellings LH, Crocker SJ, Melloni E, Park DS, Clarke PB. Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats. Neuroscience. 158: 558-69. PMID 19007862 DOI: 10.1016/J.Neuroscience.2008.10.023  0.513
2008 Hebb AL, Moore CS, Bhan V, Campbell T, Fisk JD, Robertson HA, Thorne M, Lacasse E, Holcik M, Gillard J, Crocker SJ, Robertson GS. Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination. Multiple Sclerosis (Houndmills, Basingstoke, England). 14: 577-94. PMID 18566024 DOI: 10.1177/1352458507087468  0.802
2008 Crocker SJ, Frausto RF, Whitton JL, Milner R. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia. 56: 1187-98. PMID 18449943 DOI: 10.1002/Glia.20689  0.615
2007 Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL. Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1. The American Journal of Pathology. 171: 1762-73. PMID 18055551 DOI: 10.2353/Ajpath.2007.070179  0.614
2007 Frausto RF, Crocker SJ, Eam B, Whitmire JK, Whitton JL. Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. Journal of Neuroimmunology. 192: 124-33. PMID 17964666 DOI: 10.1016/J.Jneuroim.2007.09.024  0.545
2007 Milner R, Crocker SJ, Hung S, Wang X, Frausto RF, del Zoppo GJ. Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha5beta1 and alphavbeta5. Journal of Immunology (Baltimore, Md. : 1950). 178: 8158-67. PMID 17548654 DOI: 10.4049/Jimmunol.178.12.8158  0.382
2006 Crocker SJ, Whitmire JK, Frausto RF, Chertboonmuang P, Soloway PD, Whitton JL, Campbell IL. Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. The American Journal of Pathology. 169: 2104-16. PMID 17148673 DOI: 10.2353/Ajpath.2006.060626  0.729
2006 Crocker SJ, Milner R, Pham-Mitchell N, Campbell IL. Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells. Journal of Neurochemistry. 98: 812-23. PMID 16893421 DOI: 10.1111/J.1471-4159.2006.03927.X  0.574
2006 Crocker SJ, Hayley SP, Smith PD, Mount MP, Lamba WR, Callaghan SM, Slack RS, Park DS. Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. Journal of Neurochemistry. 96: 489-99. PMID 16336220 DOI: 10.1111/J.1471-4159.2005.03568.X  0.485
2004 Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron. 44: 931-45. PMID 15603737 DOI: 10.1016/J.Neuron.2004.11.026  0.484
2004 Hayley S, Crocker SJ, Smith PD, Shree T, Jackson-Lewis V, Przedborski S, Mount M, Slack R, Anisman H, Park DS. Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2045-53. PMID 14985447 DOI: 10.1523/Jneurosci.4564-03.2004  0.53
2004 Crocker SJ, Pagenstecher A, Campbell IL. The TIMPs tango with MMPs and more in the central nervous system. Journal of Neuroscience Research. 75: 1-11. PMID 14689443 DOI: 10.1002/Jnr.10836  0.579
2003 Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 13650-5. PMID 14595022 DOI: 10.1073/Pnas.2232515100  0.52
2003 Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4081-91. PMID 12764095 DOI: 10.1523/Jneurosci.23-10-04081.2003  0.704
2003 Crocker SJ, Liston P, Anisman H, Lee CJ, Smith PD, Earl N, Thompson CS, Park DS, Korneluk RG, Robertson GS. Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. Neurobiology of Disease. 12: 150-61. PMID 12667469 DOI: 10.1016/S0969-9961(02)00020-7  0.72
2003 McPhail LT, Vanderluit JL, McBride CB, Oschipok LW, Crocker SJ, Xu D, Thompson CS, Liston P, Holcik M, Robertson GS, Tetzlaff W. Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy. Neuroscience. 117: 567-75. PMID 12617963 DOI: 10.1016/S0306-4522(02)00742-X  0.655
2001 Crocker SJ, Lamba WR, Smith PD, Callaghan SM, Slack RS, Anisman H, Park DS. c-Jun mediates axotomy-induced dopamine neuron death in vivo. Proceedings of the National Academy of Sciences of the United States of America. 98: 13385-90. PMID 11687617 DOI: 10.1073/Pnas.231177098  0.498
2001 Crocker SJ, Wigle N, Liston P, Thompson CS, Lee CJ, Xu D, Roy S, Nicholson DW, Park DS, MacKenzie A, Korneluk RG, Robertson GS. NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease. The European Journal of Neuroscience. 14: 391-400. PMID 11553289 DOI: 10.1046/J.0953-816X.2001.01653.X  0.701
2000 Robertson GS, Crocker SJ, Nicholson DW, Schulz JB. Neuroprotection by the inhibition of apoptosis. Brain Pathology (Zurich, Switzerland). 10: 283-92. PMID 10764048 DOI: 10.1111/J.1750-3639.2000.Tb00262.X  0.666
1999 Xu D, Bureau Y, McIntyre DC, Nicholson DW, Liston P, Zhu Y, Fong WG, Crocker SJ, Korneluk RG, Robertson GS. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5026-33. PMID 10366635 DOI: 10.1523/Jneurosci.19-12-05026.1999  0.639
1998 Crocker SJ, Morelli M, Wigle N, Nakabeppu Y, Robertson GS. D1-Receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression. Brain Research. Molecular Brain Research. 53: 69-77. PMID 9473593 DOI: 10.1016/S0169-328X(97)00281-7  0.64
1997 Xu DG, Crocker SJ, Doucet JP, St-Jean M, Tamai K, Hakim AM, Ikeda JE, Liston P, Thompson CS, Korneluk RG, MacKenzie A, Robertson GS. Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Nature Medicine. 3: 997-1004. PMID 9288726 DOI: 10.1038/Nm0997-997  0.645
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