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Raffi V. Aroian - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Genetics, Microbiology Biology
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sitaram A, Yin Y, Zamaitis T, Zhang B, Aroian RV. A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins. Plos Pathogens. 18: e1010656. PMID 36374839 DOI: 10.1371/journal.ppat.1010656  0.346
2020 Mirza Z, Soto ER, Hu Y, Nguyen TT, Koch D, Aroian RV, Ostroff GR. Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes. Molecules (Basel, Switzerland). 25. PMID 32605043 DOI: 10.3390/Molecules25132958  0.329
2020 Liu F, Xie Y, Zajac AM, Hu Y, Aroian RV, Urban JF, Li RW. Gut microbial signatures associated with moxidectin treatment efficacy of Haemonchus contortus in infected goats. Veterinary Microbiology. 242: 108607. PMID 32122611 DOI: 10.1016/J.Vetmic.2020.108607  0.339
2019 Charuchaibovorn S, Sanprasert V, Sutthanont N, Hu Y, Abraham A, Ostroff GR, Aroian RV, Jaleta TG, Lok JB, Nuchprayoon S. Cry5B is active against in vitro. The American Journal of Tropical Medicine and Hygiene. PMID 31516117 DOI: 10.4269/Ajtmh.19-0083  0.336
2019 Elfawal MA, Savinov SN, Aroian RV. Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes. Scientific Reports. 9: 12347. PMID 31451730 DOI: 10.1038/S41598-019-48720-1  0.317
2019 Tyagi R, Elfawal MA, Wildman SA, Helander J, Bulman CA, Sakanari J, Rosa BA, Brindley PJ, Janetka JW, Aroian RV, Mitreva M. Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics. Scientific Reports. 9: 9085. PMID 31235822 DOI: 10.1038/S41598-019-45548-7  0.308
2018 Hu Y, Nguyen TT, Lee ACY, Urban JF, Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. International Journal For Parasitology. Drugs and Drug Resistance. 8: 287-294. PMID 29772478 DOI: 10.1016/J.Ijpddr.2018.05.001  0.345
2018 Tyagi R, Maddirala AR, Elfawal M, Fischer C, Bulman C, Rosa BA, Gao X, Chugani R, Zhou M, Helander J, Brindley P, Tseng CC, Greig IR, Sakanari J, Wildman SA, ... Aroian R, et al. Small molecule inhibitors of metabolic enzymes repurposed as a new class of anthelmintics. Acs Infectious Diseases. PMID 29718656 DOI: 10.1021/Acsinfecdis.8B00090  0.304
2016 Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy. 0. PMID 27875098 DOI: 10.1080/15548627.2016.1256933  0.403
2016 Dementiev A, Board J, Sitaram A, Hey T, Kelker MS, Xu X, Hu Y, Vidal-Quist C, Chikwana V, Griffin S, McCaskill D, Wang NX, Hung SC, Chan MK, Lee MM, ... ... Aroian RV, et al. The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins. Bmc Biology. 14: 71. PMID 27576487 DOI: 10.1186/S12915-016-0295-9  0.347
2015 Durmaz E, Hu Y, Aroian RV, Klaenhammer TR. Intracellular and extracellular expression of Bacillus thuringiensis crystal protein Cry5B in Lactococcus lactis for use as an anthelminthic. Applied and Environmental Microbiology. PMID 26682852 DOI: 10.1128/Aem.02365-15  0.363
2015 von Hoven G, Neukirch C, Meyenburg M, Füser S, Petrivna MB, Rivas AJ, Ryazanov A, Kaufman RJ, Aroian RV, Husmann M. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin. Frontiers in Immunology. 6: 383. PMID 26284068 DOI: 10.3389/Fimmu.2015.00383  0.349
2015 Schwarz EM, Hu Y, Antoshechkin I, Miller MM, Sternberg PW, Aroian RV. The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families. Nature Genetics. 47: 416-22. PMID 25730766 DOI: 10.1038/Ng.3237  0.359
2014 Somvanshi VS, Ellis BL, Hu Y, Aroian RV. Nitazoxanide: nematicidal mode of action and drug combination studies. Molecular and Biochemical Parasitology. 193: 1-8. PMID 24412397 DOI: 10.1016/J.Molbiopara.2013.12.002  0.343
2014 Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM. Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infection and Immunity. 82: 1132-40. PMID 24366250 DOI: 10.1128/Iai.01614-13  0.414
2013 Hu Y, Ellis BL, Yiu YY, Miller MM, Urban JF, Shi LZ, Aroian RV. An extensive comparison of the effect of anthelmintic classes on diverse nematodes. Plos One. 8: e70702. PMID 23869246 DOI: 10.1371/Journal.Pone.0070702  0.325
2013 Hu Y, Miller MM, Derman AI, Ellis BL, Monnerat RG, Pogliano J, Aroian RV. Bacillus subtilis strain engineered for treatment of soil-transmitted helminth diseases. Applied and Environmental Microbiology. 79: 5527-32. PMID 23835175 DOI: 10.1128/Aem.01854-13  0.311
2013 Urban JF, Hu Y, Miller MM, Scheib U, Yiu YY, Aroian RV. Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum. Plos Neglected Tropical Diseases. 7: e2263. PMID 23818995 DOI: 10.1371/Journal.Pntd.0002263  0.365
2013 Los FC, Randis TM, Aroian RV, Ratner AJ. Role of pore-forming toxins in bacterial infectious diseases. Microbiology and Molecular Biology Reviews : Mmbr. 77: 173-207. PMID 23699254 DOI: 10.1128/Mmbr.00052-12  0.423
2013 Los FC, Ha C, Aroian RV. Neuronal Goα and CAPS regulate behavioral and immune responses to bacterial pore-forming toxins. Plos One. 8: e54528. PMID 23349920 DOI: 10.1371/Journal.Pone.0054528  0.389
2012 Hui F, Scheib U, Hu Y, Sommer RJ, Aroian RV, Ghosh P. Structure and glycolipid binding properties of the nematicidal protein Cry5B. Biochemistry. 51: 9911-21. PMID 23150986 DOI: 10.1021/Bi301386Q  0.319
2012 Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, Aroian RV. Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. Plos Neglected Tropical Diseases. 6: e1900. PMID 23145203 DOI: 10.1371/Journal.Pntd.0001900  0.331
2012 Hu Y, Aroian RV. Bacterial pore-forming proteins as anthelmintics. Invertebrate Neuroscience : In. 12: 37-41. PMID 22562659 DOI: 10.1007/S10158-012-0135-8  0.358
2011 Kho MF, Bellier A, Balasubramani V, Hu Y, Hsu W, Nielsen-LeRoux C, McGillivray SM, Nizet V, Aroian RV. The pore-forming protein Cry5B elicits the pathogenicity of Bacillus sp. against Caenorhabditis elegans. Plos One. 6: e29122. PMID 22216181 DOI: 10.1371/Journal.Pone.0029122  0.378
2011 Kao CY, Los FC, Huffman DL, Wachi S, Kloft N, Husmann M, Karabrahimi V, Schwartz JL, Bellier A, Ha C, Sagong Y, Fan H, Ghosh P, Hsieh M, Hsu CS, ... ... Aroian RV, et al. Global functional analyses of cellular responses to pore-forming toxins. Plos Pathogens. 7: e1001314. PMID 21408619 DOI: 10.1371/Journal.Ppat.1001314  0.709
2011 Los FC, Kao CY, Smitham J, McDonald KL, Ha C, Peixoto CA, Aroian RV. RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin. Cell Host & Microbe. 9: 147-57. PMID 21320697 DOI: 10.1016/J.Chom.2011.01.005  0.328
2010 Balla KM, Lugo-Villarino G, Spitsbergen JM, Stachura DL, Hu Y, Bañuelos K, Romo-Fewell O, Aroian RV, Traver D. Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. Blood. 116: 3944-54. PMID 20713961 DOI: 10.1182/Blood-2010-03-267419  0.362
2010 Hu Y, Platzer EG, Bellier A, Aroian RV. Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. Proceedings of the National Academy of Sciences of the United States of America. 107: 5955-60. PMID 20231450 DOI: 10.1073/Pnas.0912327107  0.335
2010 Chen CS, Bellier A, Kao CY, Yang YL, Chen HD, Los FC, Aroian RV. WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. Plos One. 5: e9494. PMID 20209166 DOI: 10.1371/Journal.Pone.0009494  0.34
2010 Hu Y, Georghiou SB, Kelleher AJ, Aroian RV. Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice. Plos Neglected Tropical Diseases. 4: e614. PMID 20209154 DOI: 10.1371/Journal.Pntd.0000614  0.338
2009 McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V. ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. Journal of Innate Immunity. 1: 494-506. PMID 20375606 DOI: 10.1159/000225955  0.343
2009 Bellier A, Chen CS, Kao CY, Cinar HN, Aroian RV. Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. Plos Pathogens. 5: e1000689. PMID 20011506 DOI: 10.1371/Journal.Ppat.1000689  0.442
2009 Hu Y, Xiao SH, Aroian RV. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. Plos Neglected Tropical Diseases. 3: e499. PMID 19668355 DOI: 10.1371/Journal.Pntd.0000499  0.313
2008 Bischof LJ, Kao CY, Los FC, Gonzalez MR, Shen Z, Briggs SP, van der Goot FG, Aroian RV. Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. Plos Pathogens. 4: e1000176. PMID 18846208 DOI: 10.1371/Journal.Ppat.1000176  0.432
2008 Li XQ, Tan A, Voegtline M, Bekele S, Chen CS, Aroian RV. Expression of Cry5B protein from Bacillus thuringiensis in plant roots confers resistance to root-knot nematode Biological Control. 47: 97-102. DOI: 10.1016/J.Biocontrol.2008.06.007  0.306
2007 Barrows BD, Griffitts JS, Aroian RV. Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans. Journal of Invertebrate Pathology. 95: 198-200. PMID 17482642 DOI: 10.1016/J.Jip.2007.04.002  0.36
2007 Li XQ, Wei JZ, Tan A, Aroian RV. Resistance to root-knot nematode in tomato roots expressing a nematicidal Bacillus thuringiensis crystal protein. Plant Biotechnology Journal. 5: 455-64. PMID 17451491 DOI: 10.1111/J.1467-7652.2007.00257.X  0.3
2007 Aroian R, van der Goot FG. Pore-forming toxins and cellular non-immune defenses (CNIDs). Current Opinion in Microbiology. 10: 57-61. PMID 17234446 DOI: 10.1016/J.Mib.2006.12.008  0.373
2007 Barrows BD, Haslam SM, Bischof LJ, Morris HR, Dell A, Aroian RV. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. The Journal of Biological Chemistry. 282: 3302-11. PMID 17135259 DOI: 10.1074/Jbc.M606621200  0.416
2006 Barrows BD, Griffitts JS, Aroian RV. Caenorhabditis elegans carbohydrates in bacterial toxin resistance. Methods in Enzymology. 417: 340-58. PMID 17132513 DOI: 10.1016/S0076-6879(06)17021-4  0.409
2006 Cappello M, Bungiro RD, Harrison LM, Bischof LJ, Griffitts JS, Barrows BD, Aroian RV. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Proceedings of the National Academy of Sciences of the United States of America. 103: 15154-9. PMID 17005719 DOI: 10.1073/Pnas.0607002103  0.384
2006 Bischof LJ, Huffman DL, Aroian RV. Assays for toxicity studies in C. elegans with Bt crystal proteins. Methods in Molecular Biology (Clifton, N.J.). 351: 139-154. PMID 16988432 DOI: 10.1385/1-59745-151-7:139  0.646
2005 Griffitts JS, Aroian RV. Many roads to resistance: how invertebrates adapt to Bt toxins. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 27: 614-24. PMID 15892110 DOI: 10.1002/Bies.20239  0.368
2005 Griffitts JS, Haslam SM, Yang T, Garczynski SF, Mulloy B, Morris H, Cremer PS, Dell A, Adang MJ, Aroian RV. Glycolipids as receptors for Bacillus thuringiensis crystal toxin. Science (New York, N.Y.). 307: 922-5. PMID 15705852 DOI: 10.1126/Science.1104444  0.335
2004 Huffman DL, Abrami L, Sasik R, Corbeil J, Van Der Goot FG, Aroian RV. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins Proceedings of the National Academy of Sciences of the United States of America. 101: 10995-11000. PMID 15256590 DOI: 10.1073/Pnas.0404073101  0.691
2004 Huffman DL, Bischof LJ, Griffitts JS, Aroian RV. Pore worms: Using Caenorhabditis elegans to study how bacterial toxins interact with their target host International Journal of Medical Microbiology. 293: 599-607. PMID 15149037 DOI: 10.1078/1438-4221-00303  0.679
2003 Rappleye CA, Tagawa A, Le Bot N, Ahringer J, Aroian RV. Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. Bmc Developmental Biology. 3: 8. PMID 14527340 DOI: 10.1186/1471-213X-3-8  0.71
2003 Griffitts JS, Huffman DL, Whitacre JL, Barrows BD, Marroquin LD, Müller R, Brown JR, Hennet T, Esko JD, Aroian RV. Resistance to a Bacterial Toxin Is Mediated by Removal of a Conserved Glycosylation Pathway Required for Toxin-Host Interactions Journal of Biological Chemistry. 278: 45594-45602. PMID 12944392 DOI: 10.1074/Jbc.M308142200  0.713
2003 Wei JZ, Hale K, Carta L, Platzer E, Wong C, Fang SC, Aroian RV. Bacillus thuringiensis crystal proteins that target nematodes. Proceedings of the National Academy of Sciences of the United States of America. 100: 2760-5. PMID 12598644 DOI: 10.1073/Pnas.0538072100  0.336
2002 Rappleye CA, Tagawa A, Lyczak R, Bowerman B, Aroian RV. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Developmental Cell. 2: 195-206. PMID 11832245 DOI: 10.1016/S1534-5807(02)00114-4  0.71
2001 Griffitts JS, Whitacre JL, Stevens DE, Aroian RV. Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme Science. 293: 860-864. PMID 11486087 DOI: 10.1126/Science.1062441  0.346
2001 Tagawa A, Rappleye CA, Aroian RV. Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo. Developmental Biology. 233: 412-24. PMID 11336504 DOI: 10.1006/Dbio.2001.0234  0.722
2000 Marroquin LD, Elyassnia D, Griffitts JS, Feitelson JS, Aroian RV. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans Genetics. 155: 1693-1699. PMID 10924467  0.32
1999 Rappleye CA, Paredez AR, Smith CW, McDonald KL, Aroian RV. The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans. Genes & Development. 13: 2838-51. PMID 10557211 DOI: 10.1101/Gad.13.21.2838  0.676
1997 Aroian RV, Field C, Pruliere G, Kenyon C, Alberts BM. Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo. The Embo Journal. 16: 1541-9. PMID 9130699 DOI: 10.1093/Emboj/16.7.1541  0.363
1994 Aroian RV, Lesa GM, Sternberg PW. Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function. The Embo Journal. 13: 360-6. PMID 8313880 DOI: 10.1002/J.1460-2075.1994.Tb06269.X  0.322
1990 Aroian RV, Koga M, Mendel JE, Ohshima Y, Sternberg PW. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature. 348: 693-9. PMID 1979659 DOI: 10.1038/348693A0  0.314
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