Marc R. Birtwistle, Ph.D. - Publications

2008 Department of Chemical Engineering University of Delaware, Newark, DE, United States 
Chemical Engineering, Biochemistry, Molecular Biology

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Smith GR, Birtwistle MR. A Mechanistic Beta-Binomial Probability Model for mRNA Sequencing Data. Plos One. 11: e0157828. PMID 27326762 DOI: 10.1371/journal.pone.0157828  0.88
2016 Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills JC, Volinsky N, Dobrzyński M, Birtwistle MR, Tsyganov MA, Kiyatkin A, Kida K, Finch AJ, Carragher NO, Kolch W, Nguyen LK, et al. Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches. Cell Systems. 2: 38-48. PMID 27136688 DOI: 10.1016/j.cels.2016.01.003  0.88
2016 Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills JC, Volinsky N, Dobrzyński M, Birtwistle MR, Tsyganov MA, Kiyatkin A, Kida K, Finch AJ, Carragher NO, Kolch W, Nguyen LK, et al. Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches Cell Systems. 2: 38-48. DOI: 10.1016/j.cels.2016.01.003  0.88
2016 Farrelly LA, Dill BD, Molina H, Birtwistle MR, Maze I. Current Proteomic Methods to Investigate the Dynamics of Histone Turnover in the Central Nervous System Methods in Enzymology. DOI: 10.1016/bs.mie.2016.01.013  0.88
2015 Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, et al. CNS Anticancer Drug Discovery and Development Conference White Paper. Neuro-Oncology. 17: vi1-26. PMID 26403167 DOI: 10.1093/neuonc/nov169  0.88
2015 Klinke DJ, Birtwistle MR. In silico model-based inference: an emerging approach for inverse problems in engineering better medicines. Current Opinion in Chemical Engineering. 10: 14-24. PMID 26309811 DOI: 10.1016/j.coche.2015.07.006  0.88
2015 Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, ... ... Birtwistle MR, et al. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity. Neuron. 87: 77-94. PMID 26139371 DOI: 10.1016/j.neuron.2015.06.014  0.88
2015 Milewska M, Romano D, Herrero A, Guerriero ML, Birtwistle M, Quehenberger F, Hatzl S, Kholodenko BN, Segatto O, Kolch W, Zebisch A. Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. Plos One. 10: e0129859. PMID 26065894 DOI: 10.1371/journal.pone.0129859  0.88
2015 Gallo JM, Birtwistle MR. Network pharmacodynamic models for customized cancer therapy. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 7: 243-51. PMID 25914386 DOI: 10.1002/wsbm.1300  0.88
2015 Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho KH, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, et al. Silence on the relevant literature and errors in implementation. Nature Biotechnology. 33: 336-9. PMID 25850052 DOI: 10.1038/nbt.3185  0.88
2015 Birtwistle MR. Analytical reduction of combinatorial complexity arising from multiple protein modification sites. Journal of the Royal Society, Interface / the Royal Society. 12. PMID 25519995 DOI: 10.1098/rsif.2014.1215  0.88
2014 DobrzyÅ„ski M, Nguyen LK, Birtwistle MR, von Kriegsheim A, Blanco Fernández A, Cheong A, Kolch W, Kholodenko BN. Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses. Journal of the Royal Society, Interface / the Royal Society. 11: 20140383. PMID 24966234 DOI: 10.1098/rsif.2014.0383  0.88
2014 Weige CC, Birtwistle MR, Mallick H, Yi N, Berrong Z, Cloessner E, Duff K, Tidwell J, Clendenning M, Wilkerson B, Farrell C, Bunz F, Ji H, Shtutman M, Creek KE, et al. Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans. Molecular Cancer Research : McR. 12: 1029-41. PMID 24743655 DOI: 10.1158/1541-7786.MCR-13-0286-T  0.88
2014 Bouhaddou M, Birtwistle MR. Dimerization-based control of cooperativity. Molecular Biosystems. 10: 1824-32. PMID 24736836 DOI: 10.1039/c4mb00022f  0.88
2014 Degasperi A, Birtwistle MR, Volinsky N, Rauch J, Kolch W, Kholodenko BN. Evaluating strategies to normalise biological replicates of Western blot data. Plos One. 9: e87293. PMID 24475266 DOI: 10.1371/journal.pone.0087293  0.88
2013 Birtwistle MR, Mager DE, Gallo JM. Mechanistic vs. Empirical network models of drug action. Cpt: Pharmacometrics & Systems Pharmacology. 2: e72. PMID 24448020 DOI: 10.1038/psp.2013.51  0.88
2013 von Thun A, Preisinger C, Rath O, Schwarz JP, Ward C, Monsefi N, Rodríguez J, Garcia-Munoz A, Birtwistle M, Bienvenut W, Anderson KI, Kolch W, von Kriegsheim A. Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity. Molecular and Cellular Biology. 33: 4526-37. PMID 24043311 DOI: 10.1128/MCB.00585-13  0.56
2013 Greene J, Birtwistle MR, Ignatowicz L, Rempala GA. Bayesian multivariate Poisson abundance models for T-cell receptor data. Journal of Theoretical Biology. 326: 1-10. PMID 23467198 DOI: 10.1016/j.jtbi.2013.02.009  0.88
2013 Wesolowski S, Birtwistle MR, Rempala GA. A comparison of methods for RNA-seq differential expression analysis and a new empirical bayes approach Biosensors. 3: 238-258. DOI: 10.3390/bios3030238  0.88
2012 Birtwistle MR, von Kriegsheim A, Dobrzyński M, Kholodenko BN, Kolch W. Mammalian protein expression noise: scaling principles and the implications for knockdown experiments. Molecular Biosystems. 8: 3068-76. PMID 22990612 DOI: 10.1039/c2mb25168j  0.88
2012 Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrzyński M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. Bmc Systems Biology. 6: 109. PMID 22920937 DOI: 10.1186/1752-0509-6-109  0.88
2012 Shull AY, Latham-Schwark A, Ramasamy P, Leskoske K, Oroian D, Birtwistle MR, Buckhaults PJ. Novel somatic mutations to PI3K pathway genes in metastatic melanoma. Plos One. 7: e43369. PMID 22912864 DOI: 10.1371/journal.pone.0043369  0.88
2012 Bruning U, Fitzpatrick SF, Frank T, Birtwistle M, Taylor CT, Cheong A. NFκB and HIF display synergistic behaviour during hypoxic inflammation. Cellular and Molecular Life Sciences : Cmls. 69: 1319-29. PMID 22068612 DOI: 10.1007/s00018-011-0876-2  0.88
2011 Birtwistle MR, von Kriegsheim A, Kida K, Schwarz JP, Anderson KI, Kolch W. Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling. Plos One. 6: e27823. PMID 22114702 DOI: 10.1371/journal.pone.0027823  0.88
2011 Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W. Raf family kinases: old dogs have learned new tricks. Genes & Cancer. 2: 232-60. PMID 21779496 DOI: 10.1177/1947601911407323  0.56
2011 Birtwistle MR, Kolch W. Biology using engineering tools: the negative feedback amplifier. Cell Cycle (Georgetown, Tex.). 10: 2069-76. PMID 21572255 DOI: 10.4161/cc.10.13.16245  0.88
2010 Sturm OE, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B, Kolch W. The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Science Signaling. 3: ra90. PMID 21177493 DOI: 10.1126/scisignal.2001212  0.88
2010 Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell. 141: 884-96. PMID 20493519 DOI: 10.1016/j.cell.2010.03.054  0.88
2009 Kholodenko BN, Birtwistle MR. Four-dimensional dynamics of MAPK information processing systems. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1: 28-44. PMID 20182652 DOI: 10.1002/wsbm.16  0.88
2009 von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, Gilbert D, Kolch W. Cell fate decisions are specified by the dynamic ERK interactome. Nature Cell Biology. 11: 1458-64. PMID 19935650 DOI: 10.1038/ncb1994  0.88
2009 Birtwistle MR, Kholodenko BN. Endocytosis and signalling: a meeting with mathematics. Molecular Oncology. 3: 308-20. PMID 19596615 DOI: 10.1016/j.molonc.2009.05.009  0.88
2008 Birtwistle MR, Ogunnaike BA. Development and analysis of models for cell-to-cell variability in protein expression Aiche Annual Meeting, Conference Proceedings 0.88
2008 Birtwistle MR, Millili PG, Ogunnaike BA. A first-principles model for eukaryotic DNA synthesis dynamics and the implications for cell cycle analysis Aiche Annual Meeting, Conference Proceedings 0.88
2007 Birtwistle MR, Hatakeyama M, Yumoto N, Ogunnaike BA, Hoek JB, Kholodenko BN. Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Molecular Systems Biology. 3: 144. PMID 18004277 DOI: 10.1038/msb4100188  0.88
2007 Birtwistle MR, Kholodenko BN, Kiyatkin A, Hoek JB, Ogunnaike BA. Experimental investigation and probabilistic modeling of switch-like signal transduction systems Aiche Annual Meeting, Conference Proceedings 0.88
2006 Birtwistle MR, Hatakeyama M, Yumoto N, Hoek JB, Kholodenko BN, Ogunnaike BA. Modeling the ErbB signaling network in MCF-7 breast cancer cells and analysis of ligand-dependent responses Aiche Annual Meeting, Conference Proceedings 0.88
2004 Birtwistle MR, Ogunnaike BA, Lombardo T. Analysis and optimization of cell-cycle specific cancer chemotherapy Aiche Annual Meeting, Conference Proceedings. 8771-8773.  0.88
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