Rebecca A. Clewell, Ph.D. - Publications

Affiliations: 
2009 Environmental Sciences & Engineering University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Toxicology

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Beames T, Moreau M, Roberts LA, Mansouri K, Haider S, Smeltz M, Nicolas CI, Doheny D, Phillips MB, Yoon M, Becker RA, McMullen PD, Andersen ME, Clewell RA, Hartman JK. The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay. Toxicology and Applied Pharmacology. 114774. PMID 31783037 DOI: 10.1016/j.taap.2019.114774  0.92
2019 Andersen ME, McMullen PD, Phillips MB, Yoon M, Pendse SN, Clewell HJ, Hartman JK, Moreau M, Becker RA, Clewell RA. Developing context appropriate toxicity testing approaches using new alternative methods (NAMs). Altex. 36: 523-534. PMID 31664457 DOI: 10.14573/altex.1906261  0.92
2019 McMullen PD, Bhattacharya S, Woods CG, Pendse SN, McBride MT, Soldatow VY, Deisenroth C, LeCluyse EL, Clewell RA, Andersen ME. Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 31628012 DOI: 10.1016/j.tiv.2019.02.017  0.92
2019 McMullen PD, Pendse SN, Black MB, Mansouri K, Haider S, Andersen ME, Clewell RA. Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 30807807 DOI: 10.1016/j.tiv.2019.02.014  0.92
2019 Clewell RA, Thompson CM, Clewell HJ. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chemico-Biological Interactions. PMID 30763550 DOI: 10.1016/j.cbi.2019.01.025  0.6
2019 Clewell HH, Gentry PR, Hack CE, Greene T, Clewell RA. An evaluation of the USEPA Proposed Approaches for applying a biologically based dose-response model in a risk assessment for perchlorate in drinking water. Regulatory Toxicology and Pharmacology : Rtp. PMID 30707931 DOI: 10.1016/j.yrtph.2019.01.028  0.32
2018 Haider S, Black MB, Parks BB, Foley B, Wetmore BA, Andersen ME, Clewell RA, Mansouri K, McMullen PD. A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation. Frontiers in Pharmacology. 9: 1072. PMID 30333746 DOI: 10.3389/fphar.2018.01072  0.92
2018 Wetmore BA, Clewell RA, Cholewa B, Parks B, Pendse SN, Black MB, Mansouri K, Haider S, Berg EL, Judson RS, Houck KA, Martin M, Clewell HJ, Andersen ME, Thomas RS, et al. Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 30218698 DOI: 10.1016/j.tiv.2018.09.006  0.92
2018 Hartman JK, Beames T, Parks B, Doheny D, Song G, Efremenko A, Yoon M, Foley B, Deisenroth C, McMullen PD, Clewell RA. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis. Toxicology and Applied Pharmacology. PMID 29782964 DOI: 10.1016/j.taap.2018.05.016  0.64
2018 McMullen PD, Andersen ME, Cholewa B, Clewell HJ, Dunnick K, Hartman J, Mansouri K, Minto MS, Nicolas CI, Phillips M, Slattery S, Yoon M, Clewell RA. Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 29391263 DOI: 10.1016/j.tiv.2018.01.027  0.92
2017 Miller MM, McMullen PD, Andersen ME, Clewell RA. Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts. Critical Reviews in Toxicology. 1-17. PMID 28675057 DOI: 10.1080/10408444.2017.1289150  0.92
2017 Sun B, Ross SM, Rowley S, Adeleye Y, Clewell RA. Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage. Environmental and Molecular Mutagenesis. PMID 28195382 DOI: 10.1002/em.22070  0.64
2016 Clewell RA, McMullen PD, Adeleye Y, Carmichael PL, Andersen ME. Pathway Based Toxicology and Fit-for-Purpose Assays. Advances in Experimental Medicine and Biology. 856: 205-230. PMID 27671724 DOI: 10.1007/978-3-319-33826-2_8  0.92
2016 Foley B, Doheny D, Black M, Pendse SN, Wetmore B, Clewell R, Andersen ME, Deisenroth C. Screening ToxCastTM prioritized chemicals for PPARG function in a human adipose-derived stem cell model of adipogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27664422 DOI: 10.1093/toxsci/kfw186  0.92
2016 Miller MM, Alyea RA, LeSommer C, Doheny DL, Rowley SM, Childs KM, Balbuena P, Ross SM, Dong J, Sun B, Andersen MA, Clewell RA. Development of an in vitro assay measuring uterine-specific estrogenic responses for use in chemical safety assessment. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27503385 DOI: 10.1093/toxsci/kfw152  0.6
2016 Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research. Reviews in Mutation Research. 767: 77-91. PMID 27036068 DOI: 10.1016/j.mrrev.2015.11.001  0.92
2016 Clewell RA, Andersen ME. Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro. Mutagenesis. PMID 26846943 DOI: 10.1093/mutage/gev078  0.92
2015 Zhang Q, Bhattacharya S, Pi J, Clewell RA, Carmichael PL, Andersen ME. Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment. Toxicological Sciences : An Official Journal of the Society of Toxicology. 147: 302-16. PMID 26408567 DOI: 10.1093/toxsci/kfv130  0.44
2014 Clewell RA, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen PD, Pendse S, Trask OJ, White A, Andersen ME. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicological Sciences : An Official Journal of the Society of Toxicology. 142: 56-73. PMID 25078064 DOI: 10.1093/toxsci/kfu153  0.44
2014 McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. A map of the PPARα transcription regulatory network for primary human hepatocytes. Chemico-Biological Interactions. 209: 14-24. PMID 24269660 DOI: 10.1016/j.cbi.2013.11.006  0.44
2014 Li Z, Sun B, Clewell RA, Adeleye Y, Andersen ME, Zhang Q. Dose-response modeling of etoposide-induced DNA damage response. Toxicological Sciences : An Official Journal of the Society of Toxicology. 137: 371-84. PMID 24241721 DOI: 10.1093/toxsci/kft259  0.92
2013 Sun B, Ross SM, Trask OJ, Carmichael PL, Dent M, White A, Andersen ME, Clewell RA. Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1877-87. PMID 23764886 DOI: 10.1016/j.tiv.2013.05.015  0.44
2013 Balbuena P, Campbell J, Clewell HJ, Clewell RA. Evaluation of a predictive in vitro Leydig cell assay for anti-androgenicity of phthalate esters in the rat. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1711-8. PMID 23578968 DOI: 10.1016/j.tiv.2013.03.015  0.6
2013 Clewell RA, Thomas A, Willson G, Creasy DM, Andersen ME. A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. Reproductive Toxicology (Elmsford, N.Y.). 35: 70-80. PMID 22944045 DOI: 10.1016/j.reprotox.2012.07.008  0.92
2013 Clewell RA, Sochaski M, Edwards K, Creasy DM, Willson G, Andersen ME. Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats. Reproductive Toxicology (Elmsford, N.Y.). 35: 56-69. PMID 22813627 DOI: 10.1016/j.reprotox.2012.07.001  0.92
2012 Campbell JL, Clewell RA, Gentry PR, Andersen ME, Clewell HJ. Physiologically based pharmacokinetic/toxicokinetic modeling. Methods in Molecular Biology (Clifton, N.J.). 929: 439-99. PMID 23007440 DOI: 10.1007/978-1-62703-050-2_18  0.44
2012 Choi K, Joo H, Campbell JL, Clewell RA, Andersen ME, Clewell HJ. In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat. Toxicology in Vitro : An International Journal Published in Association With Bibra. 26: 315-22. PMID 22186153 DOI: 10.1016/j.tiv.2011.12.002  0.92
2010 Clewell RA, Campbell JL, Ross SM, Gaido KW, Clewell HJ, Andersen ME. Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 327-34. PMID 19699292 DOI: 10.1016/j.tiv.2009.08.003  0.44
2009 Clewell RA, Pluta L, Thomas RS, Andersen ME. In utero exposure to chloroquine alters sexual development in the male fetal rat. Toxicology and Applied Pharmacology. 237: 366-74. PMID 19393257 DOI: 10.1016/j.taap.2009.04.013  0.92
2009 Clewell RA, Kremer JJ, Williams CC, Campbell JL, Sochaski MA, Andersen ME, Borghoff SJ. Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. Toxicology. 255: 80-90. PMID 19010379 DOI: 10.1016/j.tox.2008.10.010  0.44
2008 Clewell RA, Kremer JJ, Williams CC, Campbell JL, Andersen ME, Borghoff SJ. Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 241-59. PMID 18344531 DOI: 10.1093/toxsci/kfn054  0.44
2008 Clewell RA, Clewell HJ. Development and specification of physiologically based pharmacokinetic models for use in risk assessment. Regulatory Toxicology and Pharmacology : Rtp. 50: 129-43. PMID 18077066 DOI: 10.1016/j.yrtph.2007.10.012  0.6
2007 Clewell RA, Merrill EA, Gearhart JM, Robinson PJ, Sterner TR, Mattie DR, Clewell HJ. Perchlorate and radioiodide kinetics across life stages in the human: using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage. Journal of Toxicology and Environmental Health. Part A. 70: 408-28. PMID 17454566 DOI: 10.1080/15287390600755216  0.6
2004 Clewell RA, Merrill EA, Narayanan L, Gearhart JM, Robinson PJ. Evidence for competitive inhibition of iodide uptake by perchlorate and translocation of perchlorate into the thyroid. International Journal of Toxicology. 23: 17-23. PMID 15162843 DOI: 10.1080/10915810490275044  0.44
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