| Year |
Citation |
Score |
| 2023 |
Wheeler AM, Orsburn BC, Bumpus NN. Biotransformation of efavirenz and proteomic analysis of P450s and UGTs in mouse, macaque, and human brain-derived systems. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 36623884 DOI: 10.1124/dmd.122.001195 |
0.302 |
|
| 2021 |
McGuire MR, Mukhopadhyay D, Myers SL, Mosher EP, Brookheart RT, Kammers K, Sehgal A, Selen ES, Wolfgang MJ, Bumpus NN, Espenshade PJ. Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism. The Journal of Biological Chemistry. 101316. PMID 34678314 DOI: 10.1016/j.jbc.2021.101316 |
0.392 |
|
| 2020 |
Heck CJS, Seneviratne HK, Bumpus NN. Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death. Journal of Medicinal Chemistry. PMID 32065749 DOI: 10.1021/Acs.Jmedchem.9B01990 |
0.36 |
|
| 2020 |
McGuire MR, Mosher E, Myers S, Bumpus N, Espenshade P. PGRMC1 Stabilizes Cytochromes P450 And Is Required for Activity
In Vivo The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04859 |
0.387 |
|
| 2016 |
Cox PM, Bumpus NN. Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6. Chemmedchem. PMID 27860311 DOI: 10.1002/cmdc.201600519 |
0.306 |
|
| 2014 |
Cox PM, Bumpus NN. Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz. Acs Medicinal Chemistry Letters. 5: 1156-1161. PMID 25309681 DOI: 10.1021/ml500297n |
0.419 |
|
| 2014 |
Hersman EM, Bumpus NN. A targeted proteomics approach for profiling murine cytochrome P450 expression. The Journal of Pharmacology and Experimental Therapeutics. 349: 221-8. PMID 24594750 DOI: 10.1124/jpet.113.212456 |
0.335 |
|
| 2012 |
Lu Y, Hendrix CW, Bumpus NN. Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2221-30. PMID 22923690 DOI: 10.1124/dmd.112.048298 |
0.477 |
|
| 2012 |
Yanakakis LJ, Bumpus NN. Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 803-14. PMID 22269145 DOI: 10.1124/dmd.111.044404 |
0.433 |
|
| 2011 |
Bumpus NN, Johnson EF. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. The Journal of Pharmacology and Experimental Therapeutics. 339: 886-95. PMID 21896918 DOI: 10.1124/Jpet.111.184242 |
0.419 |
|
| 2010 |
Bumpus NN, Hollenberg PF. Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction. Journal of Inorganic Biochemistry. 104: 485-8. PMID 20096935 DOI: 10.1016/J.Jinorgbio.2009.12.017 |
0.561 |
|
| 2008 |
Bumpus NN, Hollenberg PF. Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity. Molecular Pharmacology. 74: 990-9. PMID 18621926 DOI: 10.1124/Mol.108.048637 |
0.641 |
|
| 2008 |
Hollenberg PF, Kent UM, Bumpus NN. Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications. Chemical Research in Toxicology. 21: 189-205. PMID 18052110 DOI: 10.1021/Tx7002504 |
0.602 |
|
| 2006 |
Bumpus NN, Kent UM, Hollenberg PF. Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 318: 345-51. PMID 16611850 DOI: 10.1124/Jpet.106.102525 |
0.663 |
|
| 2005 |
Bumpus NN, Sridar C, Kent UM, Hollenberg PF. The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 795-802. PMID 15769884 DOI: 10.1124/Dmd.105.003749 |
0.663 |
|
| 2004 |
Harleton E, Webster M, Bumpus NN, Kent UM, Rae JM, Hollenberg PF. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 310: 1011-9. PMID 15121764 DOI: 10.1124/Jpet.104.069112 |
0.603 |
|
| Show low-probability matches. |