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Geoffrey Chang - Publications

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology, General Biophysics, Biochemistry
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Nicklisch SCT, Pouv AK, Rees SD, McGrath AP, Chang G, Hamdoun A. Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares). Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 109101. PMID 34116183 DOI: 10.1016/j.cbpc.2021.109101  0.62
2020 Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, et al. Structural and functional diversity calls for a new classification of ABC transporters. Febs Letters. PMID 32978974 DOI: 10.1002/1873-3468.13935  0.317
2020 Maity K, Heumann JM, McGrath AP, Kopcho NJ, Hsu P, Krishnan S, Medrano-Soto A, Saier MH, Piñeros MA, Komives EA, Schroeder JI, Chang G, Stowell MH. cryo-EM Structure of Rice OSCA1.2 Elucidates the Mechanical Basis of Membrane Hyperosmolality Gating in Plants Biophysical Journal. 118: 211a. DOI: 10.1016/J.Bpj.2019.11.1262  0.305
2019 Kopcho N, Chang G, Komives EA. Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. Scientific Reports. 9: 15092. PMID 31641149 DOI: 10.1038/S41598-019-50578-2  0.376
2019 Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I. Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 31363053 DOI: 10.1073/Pnas.1906658116  0.328
2019 Schrankel CS, Gökirmak T, Lee CW, Chang G, Hamdoun A. Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos. Methods in Cell Biology. 151: 353-376. PMID 30948018 DOI: 10.1016/Bs.Mcb.2018.11.005  0.601
2019 Maity K, Heumann JM, McGrath AP, Kopcho NJ, Hsu P, Lee C, Mapes JH, Garza D, Krishnan S, Morgan GP, Hendargo KJ, Klose T, Rees SD, Medrano-Soto A, Saier MH, ... ... Chang G, et al. Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating. Proceedings of the National Academy of Sciences of the United States of America. 116: 14309-14318. DOI: 10.2210/Pdb6Oce/Pdb  0.388
2017 Doshi R, McGrath AP, Piñeros M, Szewczyk P, Garza DM, Kochian LV, Chang G. Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. Scientific Reports. 7: 17996. PMID 29269936 DOI: 10.1038/S41598-017-18146-8  0.414
2016 Nicklisch SC, Rees SD, McGrath AP, Gökirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, Hamdoun A. Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Science Advances. 2: e1600001. PMID 27152359 DOI: 10.1126/Sciadv.1600001  0.635
2016 He X, Garza D, Nigam SK, Chang G. Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2. Plos One. 11: e0152969. PMID 27046168 DOI: 10.1371/Journal.Pone.0152969  0.432
2015 Szewczyk P, Tao H, McGrath AP, Villaluz M, Rees SD, Lee SC, Doshi R, Urbatsch IL, Zhang Q, Chang G. Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallographica. Section D, Biological Crystallography. 71: 732-41. PMID 25760620 DOI: 10.1107/S1399004715000978  0.42
2015 Moeller A, Lee SC, Tao H, Speir JA, Chang G, Urbatsch IL, Potter CS, Carragher B, Zhang Q. Distinct conformational spectrum of homologous multidrug ABC transporters. Structure (London, England : 1993). 23: 450-60. PMID 25661651 DOI: 10.1016/J.Str.2014.12.013  0.451
2014 Doshi R, Chen BR, Vibat CR, Huang N, Lee CW, Chang G. In vitro nanobody discovery for integral membrane protein targets. Scientific Reports. 4: 6760. PMID 25342225 DOI: 10.1038/Srep06760  0.339
2014 Martinez L, Arnaud O, Henin E, Tao H, Chaptal V, Doshi R, Andrieu T, Dussurgey S, Tod M, Di Pietro A, Zhang Q, Chang G, Falson P. Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein. The Febs Journal. 281: 673-82. PMID 24219411 DOI: 10.1111/Febs.12613  0.369
2013 Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, ... Chang G, et al. Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proceedings of the National Academy of Sciences of the United States of America. 110: 13386-91. PMID 23901103 DOI: 10.1073/Pnas.1309275110  0.471
2013 Marcoux J, Wang SC, Politis A, Reading E, Ma J, Biggin PC, Zhou M, Tao H, Zhang Q, Chang G, Morgner N, Robinson CV. Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump. Proceedings of the National Academy of Sciences of the United States of America. 110: 9704-9. PMID 23690617 DOI: 10.1073/Pnas.1303888110  0.384
2013 Doshi R, Nguyen T, Chang G. Transporter-mediated biofuel secretion. Proceedings of the National Academy of Sciences of the United States of America. 110: 7642-7. PMID 23613592 DOI: 10.1073/Pnas.1301358110  0.415
2012 Zhang X, He X, Baker J, Tama F, Chang G, Wright SH. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. The Journal of Biological Chemistry. 287: 27971-82. PMID 22722930 DOI: 10.1074/Jbc.M112.386979  0.429
2011 Bai J, Swartz DJ, Protasevich II, Brouillette CG, Harrell PM, Hildebrandt E, Gasser B, Mattanovich D, Ward A, Chang G, Urbatsch IL. A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris. Plos One. 6: e22577. PMID 21826197 DOI: 10.1371/Journal.Pone.0022577  0.367
2011 Tao H, Weng Y, Zhuo R, Chang G, Urbatsch IL, Zhang Q. Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein. Chembiochem : a European Journal of Chemical Biology. 12: 868-73. PMID 21387512 DOI: 10.1002/Cbic.201100048  0.389
2011 Chang G, Ward A, Aggarwal R, Caya A. Structure of Multidrug Resistance Transporters Biophysical Journal. 100: 513a. DOI: 10.1016/J.Bpj.2010.12.3000  0.419
2010 He X, Szewczyk P, Karyakin A, Evin M, Hong WX, Zhang Q, Chang G. Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature. 467: 991-4. PMID 20861838 DOI: 10.1038/Nature09408  0.45
2010 Nguyen TA, Lieu SS, Chang G. An Escherichia coli-based cell-free system for large-scale production of functional mammalian membrane proteins suitable for X-ray crystallography. Journal of Molecular Microbiology and Biotechnology. 18: 85-91. PMID 20160448 DOI: 10.1159/000283512  0.335
2010 Gutmann DAP, Ward A, Urbatsch IL, Chang G, van Veen HW. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 Trends in Biochemical Sciences. 35: 36-42. PMID 19819701 DOI: 10.1016/J.Tibs.2009.07.009  0.451
2009 Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science (New York, N.Y.). 323: 1718-22. PMID 19325113 DOI: 10.1126/Science.1168750  0.412
2009 Ward A, Mulligan S, Carragher B, Chang G, Milligan RA. Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA. Journal of Structural Biology. 165: 169-75. PMID 19114108 DOI: 10.1016/J.Jsb.2008.11.006  0.436
2007 Chen YJ, Pornillos O, Lieu S, Ma C, Chen AP, Chang G. X-ray structure of EmrE supports dual topology model. Proceedings of the National Academy of Sciences of the United States of America. 104: 18999-9004. PMID 18024586 DOI: 10.1073/Pnas.0709387104  0.409
2007 Ward A, Reyes CL, Yu J, Roth CB, Chang G. Flexibility in the ABC transporter MsbA: Alternating access with a twist. Proceedings of the National Academy of Sciences of the United States of America. 104: 19005-10. PMID 18024585 DOI: 10.1073/Pnas.0709388104  0.455
2007 Chang G. Retraction of "Structure of MsbA from Vibrio cholera: A Multidrug Resistance ABC Transporter Homolog in a Closed Conformation" [J. Mol. Biol. (2003) 330 419-430] (DOI:10.1016/S0022-2836(03)00587-4) Journal of Molecular Biology. 369: 596. PMID 17580380 DOI: 10.1016/J.Jmb.2003.05.001  0.382
2007 Zhang Z, Ma C, Pornillos O, Xiu X, Chang G, Saier MH. Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis. Biochemistry. 46: 5218-25. PMID 17417881 DOI: 10.1021/Bi7001604  0.426
2007 Ma C, Chang G. Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 104: 3668. PMID 17360700 DOI: 10.1073/Pnas.0700711104  0.358
2006 Yin Y, He X, Szewczyk P, Nguyen T, Chang G. Structure of the multidrug transporter EmrD from Escherichia coli. Science (New York, N.Y.). 312: 741-4. PMID 16675700 DOI: 10.1126/Science.1125629  0.461
2006 Pornillos O, Chang G. Inverted repeat domains in membrane proteins. Febs Letters. 580: 358-62. PMID 16406365 DOI: 10.1016/J.Febslet.2005.12.054  0.384
2006 Reyes CL, Ward A, Yu J, Chang G. The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux. Febs Letters. 580: 1042-8. PMID 16337944 DOI: 10.1016/J.Febslet.2005.11.033  0.458
2005 Reyes CL, Chang G. Lipopolysaccharide stabilizes the crystal packing of the ABC transporter MsbA. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 655-8. PMID 16511120 DOI: 10.1107/S1744309105016969  0.33
2005 Pornillos O, Chen YJ, Chen AP, Chang G. X-ray structure of the EmrE multidrug transporter in complex with a substrate. Science (New York, N.Y.). 310: 1950-3. PMID 16373573 DOI: 10.1126/Science.1119776  0.452
2005 Reyes CL, Chang G. Structure of the ABC transporter MsbA in complex with ADP.vanadate and lipopolysaccharide. Science (New York, N.Y.). 308: 1028-31. PMID 15890884 DOI: 10.1126/Science.1107733  0.404
2004 Ma C, Chang G. Crystallography of the integral membrane protein EmrE from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography. 60: 2399-402. PMID 15583400 DOI: 10.1107/S090744490402548X  0.314
2004 Ma C, Chang G. Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 101: 2852-7. PMID 14970332 DOI: 10.1073/Pnas.0400137101  0.426
2003 Chang G. Multidrug resistance ABC transporters Febs Letters. 555: 102-105. PMID 14630327 DOI: 10.1016/S0014-5793(03)01085-8  0.436
2003 Chang G. Structure of MsbA from Vibrio cholera: A multidrug resistance ABC transporter homolog in a closed conformation Journal of Molecular Biology. 330: 419-430. PMID 12823979 DOI: 10.1016/S0022-2836(03)00587-4  0.318
2001 Chang G, Roth CB. Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science (New York, N.Y.). 293: 1793-800. PMID 11546864 DOI: 10.1126/Science.293.5536.1793  0.448
1997 Pace HC, Kercher MA, Lu P, Markiewicz P, Miller JH, Chang G, Lewis M. Lac repressor genetic map in real space Trends in Biochemical Sciences. 22: 334-339. PMID 9301333 DOI: 10.1016/S0968-0004(97)01104-3  0.302
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