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Jane X. Kelly, Ph.D. - Publications

Affiliations: 
2003 Portland State University, Portland, OR, United States 
Area:
Biochemistry, Pharmaceutical Chemistry
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kancharla P, Li Y, Yeluguri M, Dodean RA, Reynolds KA, Kelly JX. Total Synthesis and Antimalarial Activity of 2-(-Hydroxybenzyl)-prodigiosins, Isoheptylprodigiosin, and Geometric Isomers of Tambjamine MYP1 Isolated from Marine Bacteria. Journal of Medicinal Chemistry. PMID 34111350 DOI: 10.1021/acs.jmedchem.1c00748  0.3
2021 Krollenbrock A, Li Y, Kelly JX, Riscoe MK. Robenidine Analogues Are Potent Antimalarials in Drug-Resistant . Acs Infectious Diseases. 7: 1956-1968. PMID 33724773 DOI: 10.1021/acsinfecdis.1c00001  0.565
2021 Alday PH, McConnell EV, Boitz Zarella JM, Dodean RA, Kancharla P, Kelly JX, Doggett JS. Acridones Are Highly Potent Inhibitors of Tachyzoites. Acs Infectious Diseases. PMID 33723998 DOI: 10.1021/acsinfecdis.1c00016  0.355
2020 Liebman KM, Burgess SJ, Gunsaru B, Kelly JX, Li Y, Morrill W, Liebman MC, Peyton DH. Unsymmetrical Bisquinolines with High Potency against Malaria. Molecules (Basel, Switzerland). 25. PMID 32397659 DOI: 10.3390/Molecules25092251  0.662
2020 Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, ... ... Kelly JX, et al. Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. Journal of Medicinal Chemistry. PMID 32390431 DOI: 10.1021/Acs.Jmedchem.0C00539  0.522
2019 Kancharla P, Dodean RA, Li Y, Kelly JX. Boron Trifluoride Etherate Promoted Microwave-Assisted Synthesis of Antimalarial Acridones. Rsc Advances. 9: 42284-42293. PMID 35321096 DOI: 10.1039/c9ra09478d  0.377
2019 Smilkstein MJ, Pou S, Krollenbrock A, Bleyle LA, Dodean RA, Frueh L, Hinrichs DJ, Li Y, Martinson T, Munar MY, Winter RW, Bruzual I, Whiteside S, Nilsen A, Koop DR, ... Kelly JX, et al. ELQ-331 as a prototype for extremely durable chemoprotection against malaria. Malaria Journal. 18: 291. PMID 31455339 DOI: 10.1186/S12936-019-2921-9  0.436
2019 Dodean RA, Kancharla P, Li Y, Melendez V, Read L, Bane C, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, ... ... Kelly JX, et al. Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials. Journal of Medicinal Chemistry. PMID 30852885 DOI: 10.1021/Acs.Jmedchem.8B01961  0.522
2019 Kancharla P, Dodean RA, Li Y, Kelly JX. Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones Rsc Advances. 9: 42284-42293. DOI: 10.1039/C9Ra09478D  0.339
2017 Frueh L, Li Y, Mather M, Li Q, Pou S, Nilsen A, Winter RW, Forquer I, Pershing A, Xie LH, Smilkstein MJ, Caridha D, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, ... Kelly JX, et al. Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. Acs Infectious Diseases. PMID 28927276 DOI: 10.1021/Acsinfecdis.7B00062  0.482
2017 Gunsaru B, Burgess SJ, Morrill W, Kelly JX, Shomloo S, Smilkstein MJ, Liebmann K, Peyton DH. Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs. Antimicrobial Agents and Chemotherapy. PMID 28193646 DOI: 10.1128/Aac.01913-16  0.657
2016 Foss MH, Pou S, Davidson PM, Dunaj JL, Winter RW, Pou S, Licon MH, Doh JK, Li Y, Kelly JX, Dodean RA, Koop DR, Riscoe MK, Purdy GE. Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 500-508. PMID 27626102 DOI: 10.1021/Acsinfecdis.6B00052  0.395
2016 Abugrain ME, Lu W, Li Y, Serrill JD, Brumsted CJ, Osborn AR, Alani A, Ishmael JE, Kelly JX, Mahmud T. Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues. Chembiochem : a European Journal of Chemical Biology. PMID 27305101 DOI: 10.1002/Cbic.201600261  0.516
2016 Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK. Atovaquone and ELQ-300 combination therapy: A novel dual-site cytochrome bc1 inhibition strategy for malaria. Antimicrobial Agents and Chemotherapy. PMID 27270285 DOI: 10.1128/Aac.00791-16  0.464
2015 Kancharla P, Kelly JX, Reynolds KA. Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. Journal of Medicinal Chemistry. 58: 7286-309. PMID 26305125 DOI: 10.1021/Acs.Jmedchem.5B00560  0.43
2015 Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, et al. ELQ-300 prodrugs for enhanced delivery and single dose cure of malaria. Antimicrobial Agents and Chemotherapy. PMID 26124159 DOI: 10.1128/Aac.01183-15  0.381
2015 Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, et al. Inhibition of Cytochrome bc1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy. The American Journal of Tropical Medicine and Hygiene. 92: 1195-201. PMID 25918204 DOI: 10.4269/Ajtmh.14-0553  0.378
2014 Kancharla P, Lu W, Salem SM, Kelly JX, Reynolds KA. Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization. The Journal of Organic Chemistry. 79: 11674-89. PMID 25380131 DOI: 10.1021/Jo5023553  0.336
2014 Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, et al. Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers. Journal of Medicinal Chemistry. 57: 3818-34. PMID 24720377 DOI: 10.1021/Jm500147K  0.457
2013 Almabruk KH, Lu W, Li Y, Abugreen M, Kelly JX, Mahmud T. Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity Organic Letters. 15: 1678-1681. PMID 23521145 DOI: 10.1021/ol4004614  0.512
2013 Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, ... ... Kelly JX, et al. Quinolone-3-diarylethers: a new class of antimalarial drug. Science Translational Medicine. 5: 177ra37. PMID 23515079 DOI: 10.1126/Scitranslmed.3005029  0.529
2012 Pou S, Winter RW, Nilsen A, Kelly JX, Li Y, Doggett JS, Riscoe EW, Wegmann KW, Hinrichs DJ, Riscoe MK. Sontochin as a guide to the development of drugs against chloroquine-resistant malaria. Antimicrobial Agents and Chemotherapy. 56: 3475-80. PMID 22508305 DOI: 10.1128/Aac.00100-12  0.58
2011 Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry. 54: 5296-306. PMID 21736388 DOI: 10.1021/Jm200543Y  0.434
2011 Winter R, Kelly JX, Smilkstein MJ, Hinrichs D, Koop DR, Riscoe MK. Optimization of endochin-like quinolones for antimalarial activity. Experimental Parasitology. 127: 545-51. PMID 21040724 DOI: 10.1016/J.Exppara.2010.10.016  0.51
2010 Burgess SJ, Kelly JX, Shomloo S, Wittlin S, Brun R, Liebmann K, Peyton DH. Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of Medicinal Chemistry. 53: 6477-89. PMID 20684562 DOI: 10.1021/Jm1006484  0.664
2010 Andrews S, Burgess SJ, Skaalrud D, Kelly JX, Peyton DH. Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum. Journal of Medicinal Chemistry. 53: 916-9. PMID 20088608 DOI: 10.1021/Jm900972U  0.729
2009 Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK. Discovery of dual function acridones as a new antimalarial chemotype. Nature. 459: 270-3. PMID 19357645 DOI: 10.1038/Nature07937  0.582
2008 Smilkstein MJ, Forquer I, Kanazawa A, Kelly JX, Winter RW, Hinrichs DJ, Kramer DM, Riscoe MK. A drug-selected Plasmodium falciparum lacking the need for conventional electron transport. Molecular and Biochemical Parasitology. 159: 64-8. PMID 18308406 DOI: 10.1016/J.Molbiopara.2008.01.002  0.482
2008 Winter RW, Kelly JX, Smilkstein MJ, Dodean R, Hinrichs D, Riscoe MK. Antimalarial quinolones: synthesis, potency, and mechanistic studies. Experimental Parasitology. 118: 487-97. PMID 18082162 DOI: 10.1016/J.Exppara.2007.10.016  0.587
2008 Dodean RA, Kelly JX, Peyton D, Gard GL, Riscoe MK, Winter RW. Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone. Bioorganic & Medicinal Chemistry. 16: 1174-83. PMID 18023189 DOI: 10.1016/J.Bmc.2007.10.083  0.643
2007 Kelly JX, Smilkstein MJ, Cooper RA, Lane KD, Johnson RA, Janowsky A, Dodean RA, Hinrichs DJ, Winter R, Riscoe M. Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 51: 4133-40. PMID 17846138 DOI: 10.1128/Aac.00669-07  0.538
2007 Kelly JX, Winter RW, Braun TP, Osei-Agyemang M, Hinrichs DJ, Riscoe MK. Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye. Experimental Parasitology. 116: 103-10. PMID 17266952 DOI: 10.1016/J.Exppara.2006.12.001  0.413
2006 Burgess SJ, Selzer A, Kelly JX, Smilkstein MJ, Riscoe MK, Peyton DH. A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum. Journal of Medicinal Chemistry. 49: 5623-5. PMID 16942036 DOI: 10.1021/Jm060399N  0.607
2006 Winter RW, Kelly JX, Smilkstein MJ, Dodean R, Bagby GC, Rathbun RK, Levin JI, Hinrichs D, Riscoe MK. Evaluation and lead optimization of anti-malarial acridones. Experimental Parasitology. 114: 47-56. PMID 16828746 DOI: 10.1016/J.Exppara.2006.03.014  0.507
2005 Riscoe M, Kelly JX, Winter R. Xanthones as antimalarial agents: Discovery, mode of action, and optimization Current Medicinal Chemistry. 12: 2539-2549. PMID 16250876 DOI: 10.2174/092986705774370709  0.489
2004 Sriwilaijaroen N, Kelly JX, Riscoe M, Wilairat P. CyQUANT cell proliferation assay as a fluorescence-based method for in vitro screening of antimalarial activity Southeast Asian Journal of Tropical Medicine and Public Health. 35: 840-844. PMID 15916078  0.374
2004 Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M. Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening Antimicrobial Agents and Chemotherapy. 48: 1803-1806. PMID 15105138 DOI: 10.1128/Aac.48.5.1803-1806.2004  0.475
2003 Kelly JX, Ignatushchenko MV, Bouwer HG, Peyton DH, Hinrichs DJ, Winter RW, Riscoe M. Antileishmanial drug development: exploitation of parasite heme dependency. Molecular and Biochemical Parasitology. 126: 43-9. PMID 12554083 DOI: 10.1016/S0166-6851(02)00248-7  0.721
2002 Kelly JX, Winter RW, Cornea A, Peyton DH, Hinrichs DJ, Riscoe M. The kinetics of uptake and accumulation of 3,6-bis-omega-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum. Molecular and Biochemical Parasitology. 123: 47-54. PMID 12165388 DOI: 10.1016/S0166-6851(02)00118-4  0.721
2002 Kelly JX, Winter R, Peyton DH, Hinrichs DJ, Riscoe M. Optimization of xanthones for antimalarial activity: the 3,6-bis-omega-diethylaminoalkoxyxanthone series. Antimicrobial Agents and Chemotherapy. 46: 144-50. PMID 11751125 DOI: 10.1128/Aac.46.1.144-150.2002  0.721
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