Rakesh K. Jain - Publications

Affiliations: 
Engineering and Applied Sciences Harvard University, Cambridge, MA, United States 
Area:
Biomedical Engineering

348 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li W, Li S, Chen IX, Liu Y, Ramjiawan RR, Leung CH, Gerweck LE, Fukumura D, Loeffler JS, Jain RK, Duda DG, Huang P. Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model. Radiation Oncology (London, England). 16: 48. PMID 33663521 DOI: 10.1186/s13014-021-01775-9  0.36
2021 Munn LL, Stylianopoulos T, Jain NK, Hardin CC, Khandekar MJ, Jain RK. Vascular normalization to improve treatment of COVID-19: Lessons from treatment of cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33648989 DOI: 10.1158/1078-0432.CCR-20-4750  0.4
2021 Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, ... ... Jain RK, et al. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. PMID 33431577 DOI: 10.1136/gutjnl-2020-322493  0.4
2021 Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33402434 DOI: 10.1073/pnas.2021642118  0.4
2020 Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT. Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients. Neuro-Oncology Advances. 2: vdaa157. PMID 33392506 DOI: 10.1093/noajnl/vdaa157  0.36
2020 Shigeta K, Matsui A, Kikuchi H, Klein S, Mamessier E, Chen IX, Aoki S, Kitahara S, Inoue K, Shigeta A, Hato T, Ramjiawan RR, Staiculescu D, Zopf D, Fiebig L, ... ... Jain RK, et al. Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma. Journal For Immunotherapy of Cancer. 8. PMID 33234602 DOI: 10.1136/jitc-2020-001435  0.4
2020 Nayak L, Molinaro AM, Peters KB, Clarke JL, Jordan JT, de Groot JF, Nghiemphu PL, Kaley TJ, Colman H, McCluskey C, Gaffey S, Smith T, Cote DJ, Severgnini M, Yearley JH, ... ... Jain RK, et al. Randomized phase II and biomarker study of pembrolizumab plus bevacizumab versus pembrolizumab alone for recurrent glioblastoma patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33199490 DOI: 10.1158/1078-0432.CCR-20-2500  0.36
2020 Nia HT, Munn LL, Jain RK. Physical traits of cancer. Science (New York, N.Y.). 370. PMID 33122355 DOI: 10.1126/science.aaz0868  0.4
2020 Pinter M, Jain RK, Duda DG. The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review. Jama Oncology. PMID 33090190 DOI: 10.1001/jamaoncol.2020.3381  0.36
2020 Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Research Square. PMID 32908974 DOI: 10.21203/rs.3.rs-71086/v1  0.4
2020 Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America. PMID 32907939 DOI: 10.1073/Pnas.2002806117  0.92
2020 Martin JD, Duda DG, Jain RK. Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55α Complex the Answer? Circulation Research. 127: 724-726. PMID 32853096 DOI: 10.1161/CIRCRESAHA.120.317720  0.4
2020 Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RK. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nature Protocols. PMID 32681151 DOI: 10.1038/s41596-020-0328-2  0.4
2020 Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, ... ... Jain RK, et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nature Biotechnology. PMID 32042168 DOI: 10.1038/S41587-019-0404-8  0.36
2020 Martin JD, Cabral H, Stylianopoulos T, Jain RK. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges. Nature Reviews. Clinical Oncology. PMID 32034288 DOI: 10.1038/S41571-019-0308-Z  0.4
2020 Mpekris F, Voutouri C, Baish JW, Duda DG, Munn LL, Stylianopoulos T, Jain RK. Combining microenvironment normalization strategies to improve cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015113 DOI: 10.1073/Pnas.1919764117  0.4
2019 Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK. CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas. Proceedings of the National Academy of Sciences of the United States of America. PMID 31879345 DOI: 10.1073/pnas.1910856117  0.32
2019 Seano G, Jain RK. Vessel co-option in glioblastoma: emerging insights and opportunities. Angiogenesis. PMID 31679081 DOI: 10.1007/s10456-019-09691-z  0.32
2019 Gerstner E, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T. Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31558474 DOI: 10.1158/1078-0432.Ccr-19-1739  0.36
2019 Leone JP, Duda DG, Hu J, Barry WT, Trippa L, Gerstner ER, Jain RK, Tan S, Lawler E, Winer EP, Lin NU, Tolaney SM. A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases. Breast Cancer Research and Treatment. PMID 31541381 DOI: 10.1007/s10549-019-05445-z  0.36
2019 Munn LL, Jain RK. Vascular regulation of antitumor immunity. Science (New York, N.Y.). 365: 544-545. PMID 31395771 DOI: 10.1126/science.aaw7875  0.4
2019 Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Jain RK, Cobbold M, et al. Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC. Hepatology (Baltimore, Md.). PMID 31378984 DOI: 10.1002/hep.30889  0.36
2019 Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER. Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Scientific Reports. 9: 8721. PMID 31197238 DOI: 10.1038/S41598-019-44365-2  0.36
2019 Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, ... ... Jain RK, et al. Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. Jama Oncology. PMID 31145418 DOI: 10.1001/Jamaoncol.2019.0892  0.72
2019 Datta M, Coussens LM, Nishikawa H, Hodi FS, Jain RK. Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 165-174. PMID 31099649 DOI: 10.1200/EDBK_237987  0.32
2019 Amoozgar Z, Jain RK, Duda DG. Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System? Cancer Research. 79: 2104-2106. PMID 31043429 DOI: 10.1158/0008-5472.Can-19-0749  0.36
2019 Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 31040208 DOI: 10.1073/Pnas.1819889116  0.92
2019 Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, ... ... Jain RK, et al. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature Biomedical Engineering. 3: 230-245. PMID 30948807 DOI: 10.1038/s41551-018-0334-7  0.4
2019 Cleary JM, Horick NK, McCleary NJ, Abrams TA, Yurgelun MB, Azzoli CG, Rubinson DA, Brooks GA, Chan JA, Blaszkowsky LS, Clark JW, Goyal L, Meyerhardt JA, Ng K, Schrag D, ... ... Jain RK, et al. FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial. Cancer. PMID 30913304 DOI: 10.1002/cncr.32029  0.72
2019 Martin JD, Seano G, Jain RK. Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. Annual Review of Physiology. 81: 505-534. PMID 30742782 DOI: 10.1146/annurev-physiol-020518-114700  0.4
2019 Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30700545 DOI: 10.1073/Pnas.1815515116  0.92
2019 Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK. Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30700544 DOI: 10.1073/Pnas.1818322116  0.4
2019 Askoxylakis V, Ferraro GB, Badeaux M, Kodack DP, Kirst I, Shankaraiah RC, Wong CSF, Duda DG, Fukumura D, Jain RK. Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer. Npj Breast Cancer. 5: 4. PMID 30675514 DOI: 10.1038/s41523-018-0100-8  0.36
2019 Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, ... ... Jain RK, et al. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America. PMID 30659155 DOI: 10.1073/Pnas.1818357116  0.4
2019 Nia HT, Munn LL, Jain RK. Mapping physical tumor microenvironment and drug delivery. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30630829 DOI: 10.1158/1078-0432.CCR-18-3724  0.4
2019 Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, et al. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nature Protocols. PMID 30617350 DOI: 10.1038/S41596-018-0105-7  0.32
2018 Ina Ly K, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER. Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Scientific Reports. 8: 17062. PMID 30459364 DOI: 10.1038/S41598-018-34820-X  0.36
2018 Goyal L, Zheng H, Abrams TA, Miksad R, Bullock AJ, Allen JN, Yurgelun MB, Clark JW, Kambadakone A, Muzikansky A, Knowles M, Galway A, Afflitto AJ, DiNicola CF, Regan E, ... ... Jain RK, et al. A Phase II and Biomarker Study of Sorafenib Combined with FOLFOX in Patients with Advanced Hepatocellular Carcinoma (HCC). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30190369 DOI: 10.1158/1078-0432.CCR-18-0847  0.36
2018 Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150398 DOI: 10.1073/pnas.1807105115  0.32
2018 Lee EQ, Duda DG, Muzikansky A, Gerstner E, Kuhn JG, Reardon DA, Nayak L, Norden AD, Doherty L, LaFrankie D, Stefanik J, Vardam T, Smith KH, McCluskey C, Gaffey SC, ... ... Jain RK, et al. Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29941486 DOI: 10.1158/1078-0432.Ccr-18-1025  0.36
2018 Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, ... Jain RK, et al. Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer. International Journal of Radiation Oncology, Biology, Physics. PMID 29859792 DOI: 10.1016/J.Ijrobp.2018.04.026  0.36
2018 Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, ... ... Jain RK, et al. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. PMID 29766399 DOI: 10.1007/S10456-018-9613-X  0.4
2018 Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, ... ... Jain RK, et al. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. PMID 29681511 DOI: 10.1016/J.Ccell.2018.03.020  0.32
2018 Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nature Protocols. 13: 1091-1105. PMID 29674756 DOI: 10.1038/nprot.2018.020  0.4
2018 Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proceedings of the National Academy of Sciences of the United States of America. PMID 29626132 DOI: 10.1073/Pnas.1718917115  0.32
2018 Stylianopoulos T, Munn LL, Jain RK. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends in Cancer. 4: 292-319. PMID 29606314 DOI: 10.1016/J.Trecan.2018.02.005  0.4
2018 Stylianopoulos T, Munn LL, Jain RK. Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends in Cancer. 4: 258-259. PMID 29606306 DOI: 10.1016/J.Trecan.2018.02.010  0.4
2018 Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, ... ... Jain RK, et al. Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Science Translational Medicine. 10. PMID 29540614 DOI: 10.1126/Scitranslmed.Aag0945  0.72
2018 Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nature Reviews. Clinical Oncology. PMID 29508855 DOI: 10.1038/Nrclinonc.2018.29  0.36
2017 Reardon DA, Lassman AB, Schiff D, Yunus SA, Gerstner ER, Cloughesy TF, Lee EQ, Gaffey SC, Barrs J, Bruno J, Muzikansky A, Duda DG, Jain RK, Wen PY. Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. Cancer. PMID 29266174 DOI: 10.1002/cncr.31172  0.36
2017 Pinter M, Weinmann A, Wörns MA, Hucke F, Bota S, Marquardt JU, Duda DG, Jain RK, Galle PR, Trauner M, Peck-Radosavljevic M, Sieghart W. Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma. United European Gastroenterology Journal. 5: 987-996. PMID 29163965 DOI: 10.1177/2050640617695698  0.36
2017 Li W, Liu Y, Yang W, Han X, Li S, Liu H, Gerweck LE, Fukumura D, Loeffler JS, Yang BB, Jain RK, Huang P. MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma. Journal of Neuro-Oncology. PMID 29081036 DOI: 10.1007/S11060-017-2646-Y  0.32
2017 Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, Amoozgar Z, Seano G, Ferraro GB, Chatterjee S, Xu L, Fukumura D, Duda DG, Jain RK. A cerebellar window for intravital imaging of normal and disease states in mice. Nature Protocols. 12: 2251-2262. PMID 28981123 DOI: 10.1038/Nprot.2017.101  0.36
2017 Zhang N, Chen J, Ferraro G, Wu L, Datta M, Jain RK, Plotkin SR, Stemmer-Rachamimov A, Xu L. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Experimental Neurology. PMID 28911884 DOI: 10.1016/J.Expneurol.2017.09.008  0.32
2017 Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.). 357: 55-60. PMID 28684519 DOI: 10.1126/Science.Aai8515  0.92
2017 Levin VA, Chan J, Datta M, Yee JL, Jain RK. Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab. Journal of Neuro-Oncology. PMID 28631191 DOI: 10.1007/s11060-017-2528-3  0.32
2017 Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, ... ... Jain RK, et al. Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28600474 DOI: 10.1158/1078-0432.CCR-17-0256  0.92
2017 Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, ... ... Jain RK, et al. The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation. Science Translational Medicine. 9. PMID 28539475 DOI: 10.1126/Scitranslmed.Aal4682  0.92
2017 Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, Hsu FF, Duyverman AM, Kitahara S, Huang P, Dima S, ... ... Jain RK, et al. Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Scientific Reports. 7: 44123. PMID 28276530 DOI: 10.1038/Srep44123  0.36
2017 Goyal L, Zheng H, Yurgelun MB, Abrams TA, Allen JN, Cleary JM, Knowles M, Regan E, Reardon A, Khachatryan A, Jain RK, Nardi V, Borger DR, Duda DG, Zhu AX. A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma. Cancer. PMID 28192597 DOI: 10.1002/cncr.30571  0.36
2017 Mpekris F, Baish JW, Stylianopoulos T, Jain RK. Role of vascular normalization in benefit from metronomic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28174262 DOI: 10.1073/Pnas.1700340114  0.4
2017 Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096337 DOI: 10.1073/pnas.1525387114  0.92
2016 Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, ... ... Jain RK, et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 1. PMID 28966873 DOI: 10.1038/s41551-016-0004  0.92
2016 Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27908927 DOI: 10.1101/cshperspect.a031195  0.72
2016 Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Reports. 6: 37949. PMID 27905494 DOI: 10.1038/srep37949  0.4
2016 Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, ... Jain RK, et al. Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. Journal of Neuro-Oncology. PMID 27853960 DOI: 10.1007/S11060-016-2332-5  0.36
2016 Tolaney SM, Ziehr DR, Guo H, Ng MR, Barry WT, Higgins MJ, Isakoff SJ, Brock JE, Ivanova EV, Paweletz CP, Demeo MK, Ramaiya NH, Overmoyer BA, Jain RK, Winer EP, et al. Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients. The Oncologist. PMID 27789775 DOI: 10.1634/Theoncologist.2016-0229  0.36
2016 Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Translational Oncology. 9: 431-437. PMID 27751347 DOI: 10.1016/J.Tranon.2016.07.004  0.72
2016 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, ... ... Jain RK, et al. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Science Translational Medicine. 8: 360ra135. PMID 27733559 DOI: 10.1126/scitranslmed.aaf5219  1
2016 Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harbor Perspectives in Medicine. PMID 27663981 DOI: 10.1101/cshperspect.a027094  0.72
2016 Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, ... ... Jain RK, et al. Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy. Cancer Discovery. PMID 27246539 DOI: 10.1158/2159-8290.Cd-15-1177  1
2016 Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, ... ... Jain RK, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044098 DOI: 10.1073/Pnas.1525360113  1
2016 Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, ... ... Jain RK, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044097 DOI: 10.1073/Pnas.1525349113  1
2016 Blakeley JO, Ye X, Duda DG, Halpin CF, Bergner AL, Muzikansky A, Merker VL, Gerstner ER, Fayad LM, Ahlawat S, Jacobs MA, Jain RK, Zalewski C, Dombi E, Widemann BC, et al. Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26976425 DOI: 10.1200/JCO.2015.64.3817  0.36
2016 Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, ... ... Jain RK, et al. PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26861455 DOI: 10.1158/1078-0432.Ccr-15-1839  1
2016 Park KR, Monsky WL, Lee CG, Song CH, Kim DH, Jain RK, Fukumura D. Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability. Radiation Research. PMID 26771172 DOI: 10.1667/RR14190.1  0.36
2016 Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, ... ... Jain RK, et al. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Science Translational Medicine. 8: 320ra4. PMID 26738797 DOI: 10.1126/Scitranslmed.Aad0293  0.36
2016 Askoxylakis V, Ferraro GB, Kodack DP, Badeaux M, Shankaraiah RC, Seano G, Kloepper J, Vardam T, Martin JD, Naxerova K, Bezwada D, Qi X, Selig MK, Brachtel E, Duda DG, ... ... Jain RK, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. Journal of the National Cancer Institute. 108. PMID 26547932 DOI: 10.1093/Jnci/Djv313  1
2015 Singhal PK, Sassi S, Lan L, Au P, Halvorsen SC, Fukumura D, Jain RK, Seed B. Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699463 DOI: 10.1073/Pnas.1522401112  1
2015 Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D. Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. Plos One. 10: e0141392. PMID 26641266 DOI: 10.1371/journal.pone.0141392  1
2015 Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, ... ... Jain RK, et al. Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112: 14325-14330. PMID 26578779 DOI: 10.1073/Pnas.1518808112  1
2015 Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L. Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model. Proceedings of the National Academy of Sciences of the United States of America. PMID 26554010 DOI: 10.1073/Pnas.1512570112  0.36
2015 Samuel R, Duda DG, Fukumura D, Jain RK. Vascular diseases await translation of blood vessels engineered from stem cells. Science Translational Medicine. 7: 309rv6. PMID 26468328 DOI: 10.1126/scitranslmed.aaa1805  1
2015 Stylianopoulos T, Jain RK. Design considerations for nanotherapeutics in oncology. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26282377 DOI: 10.1016/J.Nano.2015.07.015  1
2015 Datta M, Via LE, Chen W, Baish JW, Xu L, Barry CE, Jain RK. Mathematical Model of Oxygen Transport in Tuberculosis Granulomas. Annals of Biomedical Engineering. PMID 26253038 DOI: 10.1007/S10439-015-1415-3  1
2015 Batista A, Riedemann L, Vardam T, Jain RK. Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment. Cancer Journal (Sudbury, Mass.). 21: 307-13. PMID 26222083 DOI: 10.1097/Ppo.0000000000000125  1
2015 Jain RK, Fukumura D, Duda DG. From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey. Cancer Journal (Sudbury, Mass.). 21: 235-6. PMID 26222072 DOI: 10.1097/PPO.0000000000000136  1
2015 Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG. An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. Nature Protocols. 10: 1264-1274. PMID 26203823 DOI: 10.1038/Nprot.2015.080  0.36
2015 Lemon CM, Karnas E, Han X, Bruns OT, Kempa TJ, Fukumura D, Bawendi MG, Jain RK, Duda DG, Nocera DG. Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors. Journal of the American Chemical Society. PMID 26149349 DOI: 10.1021/Jacs.5B04765  1
2015 Duda DG, Heist RS, Sahani DV, Stylianopoulos T, Engelman JA, Jain RK. Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112: E3454. PMID 26080434 DOI: 10.1073/Pnas.1507225112  1
2015 Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP. Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. Journal of the National Cancer Institute. 107. PMID 26063793 DOI: 10.1093/jnci/djv155  0.36
2015 Jain RK, Fukumura D, Duda DG. Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer Journal (Sudbury, Mass.). 21: 137. PMID 26049690 DOI: 10.1097/PPO.0000000000000119  1
2015 Gerstner ER, Ye X, Duda DG, Levine MA, Mikkelsen T, Kaley TJ, Olson JJ, Nabors BL, Ahluwalia MS, Wen PY, Jain RK, Batchelor TT, Grossman S. A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma. Neuro-Oncology. PMID 26008604 DOI: 10.1093/neuonc/nov085  0.36
2015 Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow BW, Muzikansky A, Ancukiewicz M, Huse JT, Ramkissoon S, Drappatz J, Norden AD, Beroukhim R, ... ... Jain RK, et al. A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25910950 DOI: 10.1158/1078-0432.Ccr-14-3220  0.36
2015 Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK. Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 1197-213. PMID 25713439 DOI: 10.1200/JCO.2014.55.9575  1
2015 Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, ... Jain RK, et al. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. Journal of the National Cancer Institute. 107. PMID 25710962 DOI: 10.1093/Jnci/Djv017  1
2015 Stylianopoulos T, Economides EA, Baish JW, Fukumura D, Jain RK. Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors. Annals of Biomedical Engineering. PMID 25670323 DOI: 10.1007/S10439-015-1276-9  1
2015 Kodack DP, Askoxylakis V, Ferraro GB, Fukumura D, Jain RK. Emerging strategies for treating brain metastases from breast cancer. Cancer Cell. 27: 163-75. PMID 25670078 DOI: 10.1016/j.ccell.2015.01.001  1
2015 Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Proceedings of the National Academy of Sciences of the United States of America. 112: 1827-32. PMID 25624495 DOI: 10.1073/Pnas.1424563112  1
2015 Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK. Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: 1547-52. PMID 25605928 DOI: 10.1073/pnas.1424024112  1
2015 Naxerova K, Jain RK. Using tumour phylogenetics to identify the roots of metastasis in humans. Nature Reviews. Clinical Oncology. 12: 258-72. PMID 25601447 DOI: 10.1038/nrclinonc.2014.238  1
2015 Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, et al. CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology (Baltimore, Md.). 61: 1591-602. PMID 25529917 DOI: 10.1002/Hep.27665  0.36
2014 Jain RK. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell. 26: 605-22. PMID 25517747 DOI: 10.1016/j.ccell.2014.10.006  1
2014 Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R. Correlative intravital imaging of cGMP signals and vasodilation in mice. Frontiers in Physiology. 5: 394. PMID 25352809 DOI: 10.3389/Fphys.2014.00394  1
2014 Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, ... ... Jain RK, et al. Magneto-fluorescent core-shell supernanoparticles. Nature Communications. 5: 5093. PMID 25298155 DOI: 10.1038/Ncomms6093  1
2014 Jain RK, Netti PA. Letter to the editor regarding recent article by Wu et al. [J. Theor. Biol. 355 (2014) pp. 194-207]. Journal of Theoretical Biology. 363: 453. PMID 25219622 DOI: 10.1016/j.jtbi.2014.08.052  1
2014 Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L. Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nature Cell Biology. 16: 931-41, 1-8. PMID 25218639 DOI: 10.1038/ncb3036  1
2014 Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK. Vessel caliber--a potential MRI biomarker of tumour response in clinical trials. Nature Reviews. Clinical Oncology. 11: 566-84. PMID 25113840 DOI: 10.1038/nrclinonc.2014.126  1
2014 Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK. Seeds and soil: unraveling the role of local tumor stroma in distant metastasis. Journal of the National Cancer Institute. 106. PMID 25082335 DOI: 10.1093/jnci/dju187  1
2014 Sharma A, Thakur VV, Shrivastava A, Jain RK, Mathur RM, Gupta R, Kuhad RC. Xylanase and laccase based enzymatic kraft pulp bleaching reduces adsorbable organic halogen (AOX) in bleach effluents: a pilot scale study. Bioresource Technology. 169: 96-102. PMID 25036336 DOI: 10.1016/j.biortech.2014.06.066  1
2014 Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 26: 14-5. PMID 25026209 DOI: 10.1016/J.Ccr.2014.06.003  1
2014 Jain AK, Jain A, Garg NK, Agarwal A, Jain A, Jain SA, Tyagi RK, Jain RK, Agrawal H, Agrawal GP. Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids and Surfaces. B, Biointerfaces. 121: 222-9. PMID 25016424 DOI: 10.1016/j.colsurfb.2014.05.041  1
2014 Jain RK, Martin JD, Stylianopoulos T. The role of mechanical forces in tumor growth and therapy. Annual Review of Biomedical Engineering. 16: 321-46. PMID 25014786 DOI: 10.1146/Annurev-Bioeng-071813-105259  1
2014 Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, ... ... Jain RK, et al. A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma. International Journal of Radiation Oncology, Biology, Physics. 89: 830-8. PMID 24867540 DOI: 10.1016/j.ijrobp.2014.03.034  1
2014 Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK. Hypermutable DNA chronicles the evolution of human colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E1889-98. PMID 24753616 DOI: 10.1073/Pnas.1400179111  1
2014 Jain RK. An indirect way to tame cancer. Scientific American. 310: 46-53. PMID 24640331 DOI: 10.1038/scientificamerican0214-46  1
2014 Sahana N, Kaur H, Jain RK, Palukaitis P, Canto T, Praveen S. The asparagine residue in the FRNK box of potyviral helper-component protease is critical for its small RNA binding and subcellular localization. The Journal of General Virology. 95: 1167-77. PMID 24526574 DOI: 10.1099/vir.0.060269-0  1
2014 Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER. Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation. The Oncologist. 19: 75-81. PMID 24309981 DOI: 10.1634/theoncologist.2013-0101  1
2014 Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology (Baltimore, Md.). 59: 1435-47. PMID 24242874 DOI: 10.1002/Hep.26790  1
2014 Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, et al. mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Cancer Discovery. 4: 42-52. PMID 24163374 DOI: 10.1158/2159-8290.Cd-13-0315  1
2014 Lemon CM, Curtin PN, Somers RC, Greytak AB, Lanning RM, Jain RK, Bawendi MG, Nocera DG. Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold. Inorganic Chemistry. 53: 1900-15. PMID 24143874 DOI: 10.1021/Ic401587R  1
2014 Singh P, Prabha K, Jain RK, Baranwal VK. N-terminal in coat protein of Garlic virus X is indispensible for its serological detection. Virus Genes. 48: 128-32. PMID 24136255 DOI: 10.1007/s11262-013-0990-3  1
2014 Sharma SK, Vignesh Kumar P, Poswal R, Rai R, Swapna Geetanjali A, Prabha K, Jain RK, Baranwal VK. Occurrence and distribution of banana streak disease and standardization of a reliable detection procedure for routine indexing of banana streak viruses in India Scientia Horticulturae. 179: 277-283. DOI: 10.1016/j.scienta.2014.09.043  1
2014 Permar V, Singh A, Pandey V, Alatar AA, Faisal M, Jain RK, Praveen S. Tospo viral infection instigates necrosis and premature senescence by micro RNA controlled programmed cell death in Vigna unguiculata Physiological and Molecular Plant Pathology. 88: 77-84. DOI: 10.1016/j.pmpp.2014.09.004  1
2014 Chung E, Yeon C, Jain RK, Fukumura D. Uncovering Tumor Biology by Intravital Microscopy Comprehensive Biomedical Physics. 4: 153-164. DOI: 10.1016/B978-0-444-53632-7.00410-X  0.36
2013 Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK. Benefits of vascular normalization are dose and time dependent--letter. Cancer Research. 73: 7144-6. PMID 24265277 DOI: 10.1158/0008-5472.Can-13-1989  1
2013 Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, ... ... Jain RK, et al. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 19059-64. PMID 24190997 DOI: 10.1073/pnas.1318022110  1
2013 Stylianopoulos T, Jain RK. Combining two strategies to improve perfusion and drug delivery in solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18632-7. PMID 24167277 DOI: 10.1073/Pnas.1318415110  1
2013 Chauhan VP, Jain RK. Strategies for advancing cancer nanomedicine. Nature Materials. 12: 958-62. PMID 24150413 DOI: 10.1038/nmat3792  1
2013 Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent FW, Duda DG, Stuart K. A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 6614-23. PMID 24088738 DOI: 10.1158/1078-0432.CCR-13-1442  1
2013 Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovi? Z, Huang P, Bawendi MG, Boucher Y, Jain RK. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nature Communications. 4: 2516. PMID 24084631 DOI: 10.1038/Ncomms3516  1
2013 Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG. Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nature Medicine. 19: 1178-83. PMID 23955713 DOI: 10.1038/nm.3289  1
2013 Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, Mason W, Mikkelsen T, Phuphanich S, Ashby LS, Degroot J, Gattamaneni R, Cher L, Rosenthal M, Payer F, ... ... Jain RK, et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 3212-8. PMID 23940216 DOI: 10.1200/JCO.2012.47.2464  1
2013 Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, ... ... Jain RK, et al. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Journal of the National Cancer Institute. 105: 1188-201. PMID 23899555 DOI: 10.1093/Jnci/Djt164  1
2013 Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK. Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 12774-9. PMID 23861493 DOI: 10.1073/Pnas.1310675110  1
2013 Sahani DV, Jiang T, Hayano K, Duda DG, Catalano OA, Ancukiewicz M, Jain RK, Zhu AX. Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy. Journal of Hematology & Oncology. 6: 51. PMID 23842041 DOI: 10.1186/1756-8722-6-51  0.36
2013 Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, ... ... Jain RK, et al. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro-Oncology. 15: 1079-87. PMID 23828240 DOI: 10.1093/Neuonc/Not082  1
2013 Jain RK, Munn LL, Fukumura D. Measuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harbor Protocols. 2013: 678-80. PMID 23818670 DOI: 10.1101/pdb.prot075721  0.4
2013 Jain RK, Munn LL, Fukumura D. Measuring interstitial pH and pO2 in mouse tumors. Cold Spring Harbor Protocols. 2013: 675-7. PMID 23818669 DOI: 10.1101/pdb.prot075713  0.4
2013 Jain RK, Munn LL, Fukumura D. Measuring leukocyte-endothelial interactions in mice. Cold Spring Harbor Protocols. 2013: 561-3. PMID 23734020 DOI: 10.1101/pdb.prot075085  0.4
2013 Dasgupta D, Suman SK, Pandey D, Ghosh D, Khan R, Agrawal D, Jain RK, Vadde VT, Adhikari DK. Design and optimization of ethanol production from bagasse pith hydrolysate by a thermotolerant yeast Kluyveromyces sp. IIPE453 using response surface methodology. Springerplus. 2: 159. PMID 23710425 DOI: 10.1186/2193-1801-2-159  1
2013 Duda DG, Munn LL, Jain RK. Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling? Journal of the National Cancer Institute. 105: 762-5. PMID 23670727 DOI: 10.1093/jnci/djt114  0.4
2013 Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 2205-18. PMID 23669226 DOI: 10.1200/JCO.2012.46.3653  1
2013 Jain RK, Munn LL, Fukumura D. Measuring vascular permeability in mice. Cold Spring Harbor Protocols. 2013: 444-6. PMID 23637370 DOI: 10.1101/pdb.prot074344  0.4
2013 Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Research. 73: 3833-41. PMID 23633490 DOI: 10.1158/0008-5472.Can-12-4521  1
2013 Jain RK, Munn LL, Fukumura D. Measuring angiogenesis and hemodynamics in mice. Cold Spring Harbor Protocols. 2013: 354-8. PMID 23547161 DOI: 10.1101/pdb.prot073916  0.4
2013 Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, ... Jain RK, et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 152: 1065-76. PMID 23452854 DOI: 10.1016/J.Cell.2013.01.036  1
2013 Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Research. 73: 2943-8. PMID 23440426 DOI: 10.1158/0008-5472.Can-12-4354  0.36
2013 Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG. Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking. Nature Materials. 12: 445-51. PMID 23377294 DOI: 10.1038/Nmat3539  1
2013 Zhu AX, Ancukiewicz M, Supko JG, Sahani DV, Blaszkowsky LS, Meyerhardt JA, Abrams TA, McCleary NJ, Bhargava P, Muzikansky A, Sheehan S, Regan E, Vasudev E, Knowles M, Fuchs CS, ... ... Jain RK, et al. Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 1557-66. PMID 23362324 DOI: 10.1158/1078-0432.CCR-12-3041  1
2013 Jain RK, Munn LL, Fukumura D. Lung window preparation in mice. Cold Spring Harbor Protocols. 2013. PMID 23282642 DOI: 10.1101/pdb.prot072678  0.4
2013 Han HS, Martin JD, Lee J, Harris DK, Fukumura D, Jain RK, Bawendi M. Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo. Angewandte Chemie (International Ed. in English). 52: 1414-9. PMID 23255143 DOI: 10.1002/Anie.201208331  1
2013 Stylianopoulos T, Soteriou K, Fukumura D, Jain RK. Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model. Annals of Biomedical Engineering. 41: 68-77. PMID 22855118 DOI: 10.1007/S10439-012-0630-4  1
2013 Jain RK, Chauhan VP, Duda DG. Vascular and Interstitial Biology of Tumors Abeloff's Clinical Oncology: Fifth Edition. 108-126.e6. DOI: 10.1016/B978-1-4557-2865-7.00008-4  0.36
2012 Jain RK. Delivery of molecular and cellular medicine to solid tumors. Advanced Drug Delivery Reviews. 64: 353-365. PMID 24511174 DOI: 10.1016/j.addr.2012.09.011  1
2012 Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK. Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital. 1. PMID 24353926 DOI: 10.4161/intv.21557  0.4
2012 Jain RK, Munn LL, Fukumura D. Liver tumor preparation in mice. Cold Spring Harbor Protocols. 2012. PMID 23209146 DOI: 10.1101/pdb.prot072371  0.4
2012 Jain RK, Munn LL, Fukumura D. Pancreatic tumor preparation in mice. Cold Spring Harbor Protocols. 2012. PMID 23209145 DOI: 10.1101/pdb.prot072363  0.4
2012 Jain RK, Munn LL, Fukumura D. Lymphangiography of the mouse ear. Cold Spring Harbor Protocols. 2012: 1179-80. PMID 23118365 DOI: 10.1101/pdb.prot072116  0.4
2012 Jain RK, Munn LL, Fukumura D. Lymphangiography of the mouse tail. Cold Spring Harbor Protocols. 2012: 1177-8. PMID 23118364 DOI: 10.1101/pdb.prot072108  0.4
2012 Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, ... ... Jain RK, et al. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proceedings of the National Academy of Sciences of the United States of America. 109: E3119-27. PMID 23071298 DOI: 10.1073/Pnas.1216078109  1
2012 Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, ... Jain RK, et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 109: 17561-6. PMID 23045683 DOI: 10.1073/pnas.1215397109  1
2012 Jain RK, Munn LL, Fukumura D. Mammary fat pad tumor preparation in mice. Cold Spring Harbor Protocols. 2012: 1115-6. PMID 23028076 DOI: 10.1101/pdb.prot071514  0.4
2012 Jain RK, Munn LL, Fukumura D. Mammary fat pad chamber preparation in mice. Cold Spring Harbor Protocols. 2012: 1113-4. PMID 23028075 DOI: 10.1101/pdb.prot071506  0.4
2012 Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L. TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America. 109: 16618-23. PMID 22996328 DOI: 10.1073/Pnas.1117610109  1
2012 Jain RK, Munn LL, Fukumura D. Corneal pocket assay in rabbits. Cold Spring Harbor Protocols. 2012: 1017-8. PMID 22949714 DOI: 10.1101/pdb.prot070052  0.4
2012 Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proceedings of the National Academy of Sciences of the United States of America. 109: 15101-8. PMID 22932871 DOI: 10.1073/Pnas.1213353109  1
2012 Jain RK, Munn LL, Fukumura D. Rabbit ear chambers. Cold Spring Harbor Protocols. 2012: 813-14. PMID 22753607 DOI: 10.1101/pdb.prot070045  0.4
2012 Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, Kulke MH, Wolpin BM, Goldstein M, Blaszkowsky L, Zhu AX, Elliott M, Regan E, Jain RK, Duda DG. Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer. Plos One. 7: e38231. PMID 22701615 DOI: 10.1371/journal.pone.0038231  0.36
2012 Kozin SV, Duda DG, Munn LL, Jain RK. Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? Journal of the National Cancer Institute. 104: 899-905. PMID 22572994 DOI: 10.1093/jnci/djs239  0.4
2012 Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nature Nanotechnology. 7: 383-8. PMID 22484912 DOI: 10.1038/Nnano.2012.45  1
2012 Vakoc BJ, Fukumura D, Jain RK, Bouma BE. Cancer imaging by optical coherence tomography: preclinical progress and clinical potential. Nature Reviews. Cancer. 12: 363-8. PMID 22475930 DOI: 10.1038/Nrc3235  1
2012 Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D. Multistage nanoparticles for improved delivery into tumor tissue. Methods in Enzymology. 508: 109-30. PMID 22449923 DOI: 10.1016/B978-0-12-391860-4.00006-9  1
2012 Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D. A transient parabiosis skin transplantation model in mice. Nature Protocols. 7: 763-70. PMID 22441295 DOI: 10.1038/nprot.2012.032  0.36
2012 Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG. Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice. Nature Protocols. 7: 756-62. PMID 22441294 DOI: 10.1038/nprot.2012.031  0.36
2012 Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK. An isolated tumor perfusion model in mice. Nature Protocols. 7: 749-55. PMID 22441293 DOI: 10.1038/nprot.2012.030  0.36
2012 Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK. Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948). Plos One. 7: e26331. PMID 22347360 DOI: 10.1371/journal.pone.0026331  1
2012 Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL. Mechanical compression drives cancer cells toward invasive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 109: 911-6. PMID 22203958 DOI: 10.1073/Pnas.1118910109  1
2012 Stylianopoulos T, Martin JD, Chauhan VP, Munn LL, Jain RK. Residual stresses in solid tumors: Implications to tumor growth and drug delivery Asme 2012 Summer Bioengineering Conference, Sbc 2012. 207-208. DOI: 10.1115/SBC2012-80235  1
2012 Stylianopoulos T, Soteriou K, Fukumura D, Jain RK. Design rules for cancer nanomedicines Ieee 12th International Conference On Bioinformatics and Bioengineering, Bibe 2012. 529-534. DOI: 10.1109/BIBE.2012.6399769  1
2012 Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG, Nocera DG. A nanocrystal-based ratiometric pH sensor for natural pH ranges Chemical Science. 3: 2980-2985. DOI: 10.1039/c2sc20212c  1
2011 Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annual Review of Chemical and Biomolecular Engineering. 2: 281-98. PMID 22432620 DOI: 10.1146/Annurev-Chembioeng-061010-114300  1
2011 Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, ... ... Jain RK, et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discovery. 1: 352-65. PMID 22145099 DOI: 10.1158/2159-8290.Cd-11-0106  1
2011 Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angewandte Chemie (International Ed. in English). 50: 11417-20. PMID 22113800 DOI: 10.1002/Anie.201104449  1
2011 Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP. Impaired lymphatic contraction associated with immunosuppression. Proceedings of the National Academy of Sciences of the United States of America. 108: 18784-9. PMID 22065738 DOI: 10.1073/Pnas.1116152108  1
2011 Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL. Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis. Blood. 118: 4740-9. PMID 21835951 DOI: 10.1182/blood-2011-02-338426  0.4
2011 Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, et al. Cell-surface sensors for real-time probing of cellular environments. Nature Nanotechnology. 6: 524-31. PMID 21765401 DOI: 10.1038/Nnano.2011.101  1
2011 Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiological Reviews. 91: 1071-121. PMID 21742796 DOI: 10.1152/Physrev.00038.2010  1
2011 Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proceedings of the National Academy of Sciences of the United States of America. 108: 11596-601. PMID 21709229 DOI: 10.1073/Pnas.1104225108  1
2011 Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Research. 71: 4527-38. PMID 21571860 DOI: 10.1158/0008-5472.CAN-10-4376  1
2011 Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG. Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Research. 71: 3745-52. PMID 21507932 DOI: 10.1158/0008-5472.Can-10-2991  1
2011 Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3638-48. PMID 21459800 DOI: 10.1158/1078-0432.Ccr-10-2456  1
2011 Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG. Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model. Plos One. 6: e17228. PMID 21390238 DOI: 10.1371/Journal.Pone.0017228  1
2011 Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 3725-30. PMID 21321210 DOI: 10.1073/Pnas.1100446108  0.36
2011 Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proceedings of the National Academy of Sciences of the United States of America. 108: 2909-14. PMID 21282607 DOI: 10.1073/pnas.1018892108  1
2011 Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proceedings of the National Academy of Sciences of the United States of America. 108: 2426-31. PMID 21245339 DOI: 10.1073/Pnas.1018382108  1
2011 Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proceedings of the National Academy of Sciences of the United States of America. 108: 1799-803. PMID 21224417 DOI: 10.1073/Pnas.1018154108  1
2011 di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK. Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape. Cancer Research. 71: 19-28. PMID 21199795 DOI: 10.1158/0008-5472.Can-10-2602  1
2011 Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK. C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 302-7. PMID 21173223 DOI: 10.1073/Pnas.1016917108  0.36
2010 Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK. Malignant cells facilitate lung metastasis by bringing their own soil. Proceedings of the National Academy of Sciences of the United States of America. 107: 21677-82. PMID 21098274 DOI: 10.1073/pnas.1016234107  0.36
2010 Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK. Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophysical Journal. 99: 3119-28. PMID 21081058 DOI: 10.1016/J.Bpj.2010.08.065  1
2010 Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG. A nanoparticle size series for in vivo fluorescence imaging. Angewandte Chemie (International Ed. in English). 49: 8649-52. PMID 20886481 DOI: 10.1002/Anie.201003142  1
2010 Jain RK, Stylianopoulos T. Delivering nanomedicine to solid tumors. Nature Reviews. Clinical Oncology. 7: 653-64. PMID 20838415 DOI: 10.1038/Nrclinonc.2010.139  1
2010 Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG. Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Research. 70: 5679-85. PMID 20631066 DOI: 10.1158/0008-5472.CAN-09-4446  1
2010 Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL. Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nature Methods. 7: 655-60. PMID 20581828 DOI: 10.1038/Nmeth.1475  1
2010 Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 116: 2173-82. PMID 20566898 DOI: 10.1182/blood-2009-12-256065  1
2010 Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Research. 70: 3483-93. PMID 20406973 DOI: 10.1158/0008-5472.CAN-09-3107  1
2010 Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG. In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model. Neuro-Oncology. 12: 341-50. PMID 20308312 DOI: 10.1093/neuonc/nop032  1
2010 Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH. In vivo wide-area cellular imaging by side-view endomicroscopy. Nature Methods. 7: 303-5. PMID 20228814 DOI: 10.1038/Nmeth.1440  1
2010 Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG. Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand. Journal of the American Chemical Society. 132: 472-83. PMID 20025223 DOI: 10.1021/Ja908137D  1
2010 Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG. InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared. Journal of the American Chemical Society. 132: 470-1. PMID 20025222 DOI: 10.1021/Ja908250R  1
2010 Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, ... Jain RK, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (New York, N.Y.). 327: 593-6. PMID 20019247 DOI: 10.1126/science.1166202  1
2009 Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK. VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. Plos One. 4: e6525. PMID 19763275 DOI: 10.1371/journal.pone.0006525  1
2009 Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nature Medicine. 15: 1219-23. PMID 19749772 DOI: 10.1038/Nm.1971  1
2009 Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophysical Journal. 97: 330-6. PMID 19580771 DOI: 10.1016/J.Bpj.2009.03.064  1
2009 Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Optics Letters. 34: 2066-8. PMID 19572001 DOI: 10.1364/Ol.34.002066  1
2009 Jain RK. A new target for tumor therapy New England Journal of Medicine. 360. PMID 19535806 DOI: 10.1056/NEJMcibr0902054  1
2009 Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK. Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. The American Journal of Pathology. 175: 294-302. PMID 19477947 DOI: 10.2353/ajpath.2009.080887  0.4
2009 di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. Plos One. 4: e5123. PMID 19352490 DOI: 10.1371/journal.pone.0005123  1
2009 Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, ... ... Jain RK, et al. Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro-Oncology. 11: 853-60. PMID 19293394 DOI: 10.1215/15228517-2009-010  1
2009 Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK. Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. Journal of Cellular Physiology. 219: 430-7. PMID 19170073 DOI: 10.1002/Jcp.21686  1
2009 Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nature Methods. 6: 143-5. PMID 19151720 DOI: 10.1038/nmeth.1295  1
2008 Duda DG, Cohen KS, Ancukiewicz M, di Tomaso E, Zhu AX, Penson RT, Horowitz NS, Batchelor TT, Willett CG, Jain RK. A comparative study of circulating endothelial cells (CECs) and circulating progenitor cells (CPCs) kinetics in four multidisciplinary phase II studies of antiangiogenic agents. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3544. PMID 27949773 DOI: 10.1200/jco.2008.26.15_suppl.3544  0.36
2008 Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Molecular Cancer Therapeutics. 7: 2272-9. PMID 18687659 DOI: 10.1158/1535-7163.MCT-08-0182  1
2008 Nagano S, Perentes JY, Jain RK, Boucher Y. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Research. 68: 3795-802. PMID 18483263 DOI: 10.1158/0008-5472.CAN-07-6193  1
2008 Jain RK. Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer Nature Reviews Cancer. 8: 309-316. PMID 18337733 DOI: 10.1038/nrc2346  1
2008 Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG. A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents. Nature Protocols. 3: 388-97. PMID 18323810 DOI: 10.1038/nprot.2007.537  0.4
2008 Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nature Medicine. 14: 255-7. PMID 18278052 DOI: 10.1038/Nm1730  1
2008 Jain RK. Taming vessels to treat cancer Scientific American. 298: 56-63. PMID 18225696 DOI: 10.1038/scientificamerican0108-56  1
2008 Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood. 111: 1302-5. PMID 17993613 DOI: 10.1182/blood-2007-06-094318  1
2008 Rennie J, Fagin D, Jain RK, Tarduno JA, Titze IR, Wang ZL. Big and small solutions Scientific American. 298: 8.  1
2007 Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia (New York, N.Y.). 9: 1038-45. PMID 18084611 DOI: 10.1593/neo.07643  1
2007 Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Research. 67: 5076-82. PMID 17545583 DOI: 10.1158/0008-5472.CAN-06-3664  1
2007 Duda DG, Cohen KS, Scadden DT, Jain RK. A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nature Protocols. 2: 805-10. PMID 17446880 DOI: 10.1038/nprot.2007.111  1
2007 Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Research. 67: 2729-35. PMID 17363594 DOI: 10.1158/0008-5472.CAN-06-4102  1
2007 Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nature Biotechnology. 25: 317-8. PMID 17322871 DOI: 10.1038/nbt1287  1
2007 Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. Journal of the Society For Integrative Oncology. 5: 11-7. PMID 17309809 DOI: 10.2310/7200.2006.033  1
2007 Tyrrell JA, di Tomaso E, Fuja D, Tong R, Kozak K, Jain RK, Roysam B. Robust 3-D modeling of vasculature imagery using superellipsoids. Ieee Transactions On Medical Imaging. 26: 223-37. PMID 17304736 DOI: 10.1109/Tmi.2006.889722  1
2007 Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, ... ... Jain RK, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 11: 83-95. PMID 17222792 DOI: 10.1016/J.Ccr.2006.11.021  1
2007 Jain RK, Fukumura D, Munn L, Brown E. Optical Microscopy in Small Animal Research Textbook of in Vivo Imaging in Vertebrates. 183-190. DOI: 10.1002/9780470029596.ch6  1
2006 Reddy ST, Berk DA, Jain RK, Swartz MA. A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 1162-9. PMID 16763103 DOI: 10.1152/japplphysiol.00389.2006  0.32
2006 Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Research. 66: 3971-7. PMID 16618713 DOI: 10.1158/0008-5472.Can-04-3085  1
2006 Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Research. 66: 3360-4. PMID 16585153 DOI: 10.1158/0008-5472.Can-05-2655  1
2006 Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK. Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 1449-53. PMID 16549839 DOI: 10.1200/JCO.2005.04.2861  1
2006 McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Research. 66: 2509-13. PMID 16510565 DOI: 10.1158/0008-5472.Can-05-2242  1
2006 Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proceedings of the National Academy of Sciences of the United States of America. 103: 855-60. PMID 16418262 DOI: 10.1073/pnas.0510412103  0.36
2006 Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood. 107: 2774-6. PMID 16339405 DOI: 10.1182/blood-2005-08-3210  1
2006 Tyrrell JA, Roysam B, Di Tomaso E, Tong R, Brown EB, Jain RK. Robust 3-D modeling of tumor microvasculature using superellipsoids 2006 3rd Ieee International Symposium On Biomedical Imaging: From Nano to Macro - Proceedings. 2006: 185-188.  1
2005 Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B. A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy. Microvascular Research. 70: 165-78. PMID 16239015 DOI: 10.1016/J.Mvr.2005.08.005  1
2005 Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, ... ... Jain RK, et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell. 8: 131-41. PMID 16098466 DOI: 10.1016/j.ccr.2005.07.003  1
2005 Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Research. 65: 5674-82. PMID 15994941 DOI: 10.1158/0008-5472.Can-04-1682  1
2005 Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. The Journal of Clinical Investigation. 115: 1816-27. PMID 15951843 DOI: 10.1172/Jci24015  0.4
2005 Jain RK. Antiangiogenic therapy for cancer: current and emerging concepts Oncology (Williston Park, N.Y.). 19: 7-16. PMID 15934498  1
2005 Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nature Medicine. 11: 678-82. PMID 15880117 DOI: 10.1038/Nm1247  1
2005 Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy Science. 307: 58-62. PMID 15637262 DOI: 10.1126/science.1104819  1
2005 Mahadevan V, Tyrrell JA, Tong RT, Brown EB, Jain RK, Roysam B. Complexity analysis of angiogenesis vasculature Progress in Biomedical Optics and Imaging - Proceedings of Spie. 5747: 526-536. DOI: 10.1117/12.596016  1
2005 Sharma RC, Jain RK. Conductivity, viscosity and volumetric behavior of molten hydrates of M3+ and M2+ ions Journal of the Indian Chemical Society. 82: 1079-1086.  1
2004 Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 6: 553-63. PMID 15607960 DOI: 10.1016/J.Ccr.2004.10.011  1
2004 Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. Differential transplantability of tumor-associated stromal cells. Cancer Research. 64: 5920-4. PMID 15342367 DOI: 10.1158/0008-5472.Can-04-1268  1
2004 Sarkar R, Jain RK. Pachyoncyhia congenita type 2 [6] Pediatric Dermatology. 21: 517-518. PMID 15283812 DOI: 10.1111/j.0736-8046.2004.21430.x  1
2004 Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Research. 64: 3731-6. PMID 15172975 DOI: 10.1158/0008-5472.CAN-04-0074  1
2004 Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvascular Research. 67: 231-6. PMID 15121448 DOI: 10.1016/J.Mvr.2004.02.001  1
2004 Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, ... ... Jain RK, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature Medicine. 10: 145-7. PMID 14745444 DOI: 10.1038/nm988  1
2004 Tyrrell JA, Mahadevan V, Tong R, Roysam B, Brown EB, Jain RK. Robust parametric modeling for improved segmentation of complex tumor microvasculature from multiphoton microscopy data Microscopy and Microanalysis. 10: 176-177. DOI: 10.1017/S1431927604885787  1
2003 Roose T, Netti PA, Munn LL, Boucher Y, Jain RK. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvascular Research. 66: 204-12. PMID 14609526 DOI: 10.1016/S0026-2862(03)00057-8  1
2003 Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B. Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series. Microvascular Research. 66: 113-25. PMID 12935769 DOI: 10.1016/S0026-2862(03)00039-6  1
2003 Jain RK. Molecular regulation of vessel maturation Nature Medicine. 9: 685-693. PMID 12778167 DOI: 10.1038/nm0603-685  1
2003 Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK. A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood. 102: 2555-61. PMID 12775571 DOI: 10.1182/blood-2003-02-0365  0.4
2003 Netti PA, Travascio F, Jain RK. Coupled macromolecular transport and gel mechanics: Poroviscoelastic approach Aiche Journal. 49: 1580-1596. DOI: 10.1002/aic.690490621  1
2002 Jain RK. Angiogenesis and lymphangiogenesis in tumors: Insights from intravital microscopy Cold Spring Harbor Symposia On Quantitative Biology. 67: 239-248. PMID 12858546  1
2002 Jain RK. Tumor angiogenesis and accessibility: role of vascular endothelial growth factor Seminars in Oncology. 29: 3-9. PMID 12516032  1
2002 Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science (New York, N.Y.). 296: 1883-6. PMID 11976409 DOI: 10.1126/Science.1071420  1
2002 Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK. Solid stress facilitates spheroid formation: potential involvement of hyaluronan. British Journal of Cancer. 86: 947-53. PMID 11953828 DOI: 10.1038/sj.bjc.6600158  1
2002 Anuradha, Jain RK. Angioarchitecture of the epididymis in camel (Camelus dromedarius) Indian Journal of Animal Sciences. 72: 368-371.  1
2002 Anuradha, Jain RK. Venography of renal vein with special reference to the venous drainage of kidney in camel (Camelus dromedarius) Indian Veterinary Journal. 79: 1047-1050.  1
2001 Jain RK, Forbes NS. Can engineered bacteria help control cancer? Proceedings of the National Academy of Sciences of the United States of America. 98: 14748-50. PMID 11752416 DOI: 10.1073/Pnas.261606598  1
2001 Tsuzuki Y, Carreira CM, Bockhorn M, Xu L, Jain RK, Fukumura D. Pancreas microenvironment promotes VEGF expression and tumor growth: Novel window models for pancreatic tumor angiogenesis and microcirculation Laboratory Investigation. 81: 1439-1451. PMID 11598156 DOI: 10.1038/Labinvest.3780357  1
2001 Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy Nature Medicine. 7: 987-989. PMID 11533692 DOI: 10.1038/nm0901-987  1
2001 Jain RK. Delivery of molecular medicine to solid tumors: Lessons from in vivo imaging of gene expression and function Journal of Controlled Release. 74: 7-25. PMID 11489479 DOI: 10.1016/S0168-3659(01)00306-6  1
2001 Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Medicine. 7: 864-8. PMID 11433354 DOI: 10.1038/89997  1
2001 Jain RK. Clearing the smoke on nicotine and angiogenesis Nature Medicine. 7: 775-777. PMID 11433337 DOI: 10.1038/89889  1
2001 Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 4628-33. PMID 11274375 DOI: 10.1073/Pnas.081626898  1
2001 Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, Munn LL. Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation. Microvascular Research. 61: 203-10. PMID 11254400 DOI: 10.1006/Mvre.2000.2298  1
2001 Brown EB, Campbell RB, Tsuzuki Y, Fukumura D, Jain RK. Measurement of physiological parameters in tumors in vivo using MPLSM Proceedings of Spie - the International Society For Optical Engineering. 4262: 134-145. DOI: 10.1117/12.424547  1
2000 Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK. Formation of endothelial cell networks. Nature. 405: 139-41. PMID 10821260 DOI: 10.1038/35012132  1
2000 Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM. Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvascular Research. 59: 265-77. PMID 10684732 DOI: 10.1006/Mvre.1999.2225  1
1999 Jain RK. Transport of molecules, particles, and cells in solid tumors Annual Review of Biomedical Engineering. 241-263. PMID 11701489 DOI: 10.1146/annurev.bioeng.1.1.241  1
1999 Jain RK. Understanding barriers to drug delivery: High resolution in vivo imaging is key Clinical Cancer Research. 5: 1605-1606. PMID 10430057  1
1999 Kristensen CA, Askenasy N, Jain RK, Koretsky AP. Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies. British Journal of Cancer. 79: 278-85. PMID 9888469 DOI: 10.1038/sj.bjc.6690045  1
1999 Jain RK. Role of physiology in drug delivery into tumors Proceedings of the Controlled Release Society. 84.  1
1999 Jain RK, Anuradha. Venography of testicular vein with special reference to the venous drainage of the testis in camel (Camelus dromedarius) Journal of Camel Practice and Research. 6: 317-321.  1
1998 Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B. Tumor induction of VEGF promoter activity in stromal cells. Cell. 94: 715-25. PMID 9753319 DOI: 10.1016/S0092-8674(00)81731-6  1
1998 Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394: 485-90. PMID 9697772 DOI: 10.1038/28867  1
1998 Jain RK. The next frontier of molecular medicine: Delivery of therapeutics Nature Medicine. 4: 655-657. PMID 9623964 DOI: 10.1038/nm0698-655  1
1998 Jain RK. Integrative pathophysiology of solid tumors: Role in detection and treatment Cancer Journal From Scientific American. 4. PMID 9619271  1
1998 Rosenzweig M, DeMaria MA, Harper DM, Friedrich S, Jain RK, Johnson RP. Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques. Proceedings of the National Academy of Sciences of the United States of America. 95: 6388-93. PMID 9600975 DOI: 10.1073/pnas.95.11.6388  1
1997 Jain RK. Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies Journal of Nuclear Medicine. 38: 731-741. PMID 9170438  1
1997 Jain RK. The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors Microcirculation (New York, N.Y. : 1994). 4: 1-23. PMID 9110280 DOI: 10.3109/10739689709148314  1
1997 Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors Aiche Journal. 43: 818-833. DOI: 10.1002/Aic.690430327  1
1996 Jain RK. 1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors Annals of Biomedical Engineering. 24: 457-473. PMID 8841721 DOI: 10.1007/BF02648108  1
1996 Berk DA, Swartz MA, Leu AJ, Jain RK. Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching. The American Journal of Physiology. 270: H330-7. PMID 8769769 DOI: 10.1152/ajpheart.1996.270.1.H330  0.32
1996 Jain RK, Matta KL. Chemical synthesis of a hexasaccharide comprising the LewisX determinant linked β-(1 → 6) to a linear trimannosyl core and the precursor pentasaccharide lacking fucose Carbohydrate Research. 282: 101-111. PMID 8721739 DOI: 10.1016/0008-6215(95)00376-2  1
1996 Jain RK. Delivery of molecular medicine to solid tumors Science. 271: 1079-1080. PMID 8599082 DOI: 10.1126/science.271.5252.1079  1
1995 Jain RK, Janda KD, Saltzman WM. Drug discovery and delivery Molecular Medicine Today. 1: 4. PMID 9415129 DOI: 10.1016/1357-4310(95)80005-0  1
1995 Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK. Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood. 86: 3487-92. PMID 7579454 DOI: 10.1182/Blood.V86.9.3487.Bloodjournal8693487  1
1994 Jain RK. Barriers to drug delivery in solid tumors Scientific American. 271: 58-65. PMID 8066425  1
1994 Leu AJ, Berk DA, Yuan F, Jain RK. Flow velocity in the superficial lymphatic network of the mouse tail. The American Journal of Physiology. 267: H1507-13. PMID 7943396 DOI: 10.1152/ajpheart.1994.267.4.H1507  0.32
1994 Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK. A method for labeling cells for positron emission tomography (PET) studies Journal of Immunological Methods. 175: 79-87. PMID 7930641 DOI: 10.1016/0022-1759(94)90333-6  1
1994 Melder RJ, Jain RK. Reduction of rigidity in human activated natural killer cells by thioglycollate treatment Journal of Immunological Methods. 175: 69-77. PMID 7930640 DOI: 10.1016/0022-1759(94)90332-8  1
1994 Martin GR, Jain RK. Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Research. 54: 5670-4. PMID 7923215  1
1994 Jain RK. Transport Phenomena in Tumors Advances in Chemical Engineering. 19: 129-200. DOI: 10.1016/S0065-2377(08)60214-8  1
1993 Eskey CJ, Koretsky AP, Domach MM, Jain RK. Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR. Proceedings of the National Academy of Sciences of the United States of America. 90: 2646-50. PMID 8464871 DOI: 10.1073/pnas.90.7.2646  1
1993 Martin GR, Jain RK. Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues. Microvascular Research. 46: 216-30. PMID 8246820 DOI: 10.1006/mvre.1993.1048  1
1992 Jain RK, Matta KL. Synthesis of oligosaccharides containing the X-antigenic trisaccharide (α-l-Fucp-(1→3)-[β-d-Galp-(1→4)]-β-d-GlcpNAc) at their nonreducing ends Carbohydrate Research. 226: 91-100. PMID 1499025 DOI: 10.1016/0008-6215(92)84057-Y  1
1992 Melder RJ, Jain RK. Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells Cell Biophysics. 20: 161-176. PMID 1285298 DOI: 10.1007/BF02823656  1
1992 Jain RK, Matta KL. Methyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-1-thio-β-D-glucopyranoside-a novel reagent for α-glycosylation towards nitrophenyl or benzyl glycosides Bioorganic and Medicinal Chemistry Letters. 2: 1707-1712. DOI: 10.1016/S0960-894X(00)80461-8  1
1991 Jain RK. Therapeutic implications of tumor physiology Current Opinion in Oncology. 3: 1105-1108. PMID 1843113  1
1991 Stock RJ, Jain RK. Assessment of fluid movement in tissues by fluorescence photobleaching Annals of Biomedical Engineering. 19: 555.  1
1990 Jain RK. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors Cancer Research. 50. PMID 2404582  1
1990 Khan SH, Jain RK, Abbas SA, Matta KL. Synthesis of some monodeoxyfluorinated methyl and 4-nitrophenyl alpha-D-mannobiosides and a related 4-nitrophenyl alpha-D-mannotrioside. Carbohydrate Research. 198: 259-73. PMID 2379188 DOI: 10.1016/0008-6215(90)84297-8  1
1990 Jain RK, Stock RJ, Chary SR, Rueter M. Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: In vitro calibration and assessment Microvascular Research. 39: 77-93. PMID 2314308 DOI: 10.1016/0026-2862(90)90060-5  1
1990 Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors Cancer and Metastasis Review. 9: 253-266. PMID 2292138 DOI: 10.1007/BF00046364  1
1990 Jain RK. Tumor physiology and antibody delivery Frontiers of Radiation Therapy and Oncology. 24: 32-46; discussion 64. PMID 2187763  1
1990 Jain RK, Matta KL. Synthesis of methyl 2-O-(sodium α-l-fucopyranosyl 3- and 4-sulfate)-α-l-fucopyranoside Carbohydrate Research. 208: 280-286. PMID 2085815 DOI: 10.1016/0008-6215(90)80112-G  1
1990 Jain RK, Matta KL. Synthesis of the sodium salts of methyl 2-O-α-l-fucopyranosyl-α-l-fucopyranoside 3- and 4-sulfate Carbohydrate Research. 208: 51-58. PMID 1964872 DOI: 10.1016/0008-6215(90)80084-G  1
1990 Jain RK, Matta KL. Methyl 3,4-0-isopropylidene-2-O-(4-methoxybenzyl)-1-thio-β-L-fucopyranoside - a novel, efficient glycosylating reagent for the synthesis of linear and other α-L-fucosyl oligosaccharides Tetrahedron Letters. 31: 4325-4328. DOI: 10.1016/S0040-4039(00)97612-3  1
1989 Chary SR, Jain RK. Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching Proceedings of the National Academy of Sciences of the United States of America. 86: 5385-5389. PMID 2748592 DOI: 10.1073/pnas.86.14.5385  1
1989 Jain RK. Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies Journal of the National Cancer Institute. 81: 570-576. PMID 2649688 DOI: 10.1093/jnci/81.8.570  1
1988 Jain RK, Abbas SA, Matta KL. Use of O-(2,3,4-tri-O-acetyl-alpha-L-fucopyranosyl)-(1----3)-O-(2-acetamido- 4,6-di-O-acetyl-2-deoxy-beta-D-glucopyranosyl)-(1----3)-2,4,6-tri-O- acetyl-alpha-D-galactopyranosyl bromide as a glycosyl donor. Synthesis of 4-nitrophenyl O-alpha-L-fucopyranosyl-(1----3)-O-(2-acetamido-2-deoxy-beta-D- glucopyranosyl)-(1----3)-beta-D-galactopyranoside. Carbohydrate Research. 173: 297-302. PMID 3359457 DOI: 10.1016/S0008-6215(00)90826-7  1
1988 Jain RK, Kohata K, Abbas SA, Matta KL. Synthesis of the isomeric trisaccharides, methyl O-alpha-L-fucopyranosyl- (1----3, 4, and 6)-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-(1----3)-beta- D-galactopyranoside. Carbohydrate Research. 172: 27-35. PMID 3349501 DOI: 10.1016/S0008-6215(00)90841-3  1
1988 Ward KA, Jain RK. Invited review: Response of tumours to hyperglycaemia: Characterization, significance and role in hyperthermia International Journal of Hyperthermia. 4: 223-250. PMID 3290346 DOI: 10.3109/02656738809051100  1
1988 Jain RK. Determinants of Tumor Blood Flow: A Review Cancer Research. 48: 2641-2658. PMID 3282647  1
1988 Jain RK. Transvascular and interstitial transport in tumors Advances in Experimental Medicine and Biology. 242: 215-220. PMID 2469315  1
1987 Dubey R, Jain RK, Abbas SA, Matta KL. Synthesis of methyl 3-O-alpha-D-mannopyranosyl-alpha-D-talopyranoside and methyl 3-O-alpha-D-talopyranosyl-alpha-D-talopyranoside. Carbohydrate Research. 165: 189-96. PMID 3664524 DOI: 10.1016/0008-6215(87)80098-8  1
1987 Jain RK, Abbas SA, Matta KL. Selective phosphorylation of the primary hydroxyl groups of methyl 2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranoside. Carbohydrate Research. 161: 318-23. PMID 3581112 DOI: 10.1016/S0008-6215(00)90090-9  1
1987 Jain RK, Dubey R, Abbas SA, Matta KL. Synthesis of methyl 2-O-alpha-D-mannopyranosyl-alpha-D-talopyranoside and methyl 2-O-alpha-D-talopyranosyl-alpha-D-talopyranoside. Carbohydrate Research. 161: 31-7. PMID 3567998 DOI: 10.1016/0008-6215(87)84003-X  1
1987 Jain RK. Transport of Molecules in the Tumor Interstitium: A Review Cancer Research. 47: 3039-3051. PMID 3555767  1
1987 Jain RK. Transport of molecules across tumor vasculature Cancer and Metastasis Review. 6: 559-593. PMID 3327633 DOI: 10.1007/BF00047468  1
1985 Jain RK. Transport of macromolecules in tumor microcirculation Biotechnology Progress™. 1: 81-94. DOI: 10.1002/btpr.5420010205  1
1984 Nugent LJ, Jain RK. Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues Microvascular Research. 28: 270-274. PMID 6209533 DOI: 10.1016/0026-2862(84)90022-0  1
1984 Nugent LJ, Jain RK. Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed The American Journal of Physiology. 246. PMID 6198927 DOI: 10.1152/ajpheart.1984.246.1.H129  1
1984 Nugent LJ, Jain RK. Two-compartment model for plasma pharmacokinetics in individual blood vessels Journal of Pharmacokinetics and Biopharmaceutics. 12: 451-461. PMID 6084709 DOI: 10.1007/BF01062668  1
1982 Nugent LJ, Jain RK. Monitoring transport in the rabbit ear chamber Microvascular Research. 24: 204-209. PMID 7176939 DOI: 10.1016/0026-2862(82)90057-7  1
1982 Maldarelli C, Jain RK. The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. II. Extension of the theory to the study of the onset of small-scale cell membrane motions Journal of Colloid and Interface Science. 90: 263-276. DOI: 10.1016/0021-9797(82)90418-0  1
1982 Maldarelli C, Jain RK. The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation Journal of Colloid and Interface Science. 90: 233-262. DOI: 10.1016/0021-9797(82)90417-9  1
1980 Jain RK. Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia Annals of the New York Academy of Sciences. 335: 48-66. PMID 6931539 DOI: 10.1111/j.1749-6632.1980.tb50736.x  1
1979 Jain RK. TRANSIENT TEMPERATURE DISTRIBUTIONS IN AN INFINITE, PERFUSED MEDIUM DUE TO A TIME-DEPENDENT, SPHERICAL HEAT SOURCE Journal of Biomechanical Engineering. 101: 82-86.  1
1974 Jain RK. Vibration of fluid-filled, orthotropic cylindrical shells Journal of Sound and Vibration. 37: 379-388. DOI: 10.1016/S0022-460X(74)80253-1  1
Show low-probability matches.