| Year |
Citation |
Score |
| 2023 |
Chen J, Wang R, Xiong F, Sun H, Kemper B, Li W, Kemper JK. Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice. Biorxiv : the Preprint Server For Biology. PMID 38045226 DOI: 10.1101/2023.11.20.567833 |
0.384 |
|
| 2023 |
Kim YC, Qi M, Dong X, Seok S, Sun H, Kemper B, Fu T, Kemper JK. Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease. The Journal of Biological Chemistry. 104946. PMID 37348559 DOI: 10.1016/j.jbc.2023.104946 |
0.461 |
|
| 2022 |
Seok S, Kemper JK. Paradoxical feeding activation of gut lipophagy by FGF15/FGF19-NR0B2/SHP-TFEB. Autophagy. PMID 35913833 DOI: 10.1080/15548627.2022.2108296 |
0.375 |
|
| 2022 |
Seok S, Kim YC, Zhang Y, Kong B, Guo G, Ma J, Kemper B, Kemper JK. Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut. The Embo Journal. e109997. PMID 35686465 DOI: 10.15252/embj.2021109997 |
0.411 |
|
| 2020 |
Seok S, Sun H, Kim YC, Kemper B, Kemper JK. Defective FXR-SHP Regulation in Obesity Aberrantly Increases Expression, Promoting Insulin Resistance and Fatty Liver. Diabetes. PMID 33328206 DOI: 10.2337/db20-0856 |
0.336 |
|
| 2020 |
Jung H, Chen J, Hu X, Sun H, Wu SY, Chiang CM, Kemper B, Chen LF, Kemper J. BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination. Jci Insight. PMID 33290278 DOI: 10.1172/jci.insight.141640 |
0.381 |
|
| 2020 |
Kim YC, Seok S, Zhang Y, Ma J, Kong B, Guo G, Kemper B, Kemper JK. Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A. Nature Communications. 11: 5969. PMID 33235221 DOI: 10.1038/s41467-020-19803-9 |
0.444 |
|
| 2020 |
Byun S, Seok S, Kim YC, Zhang Y, Yau P, Iwamori N, Xu HE, Ma J, Kemper B, Kemper JK. Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase. Nature Communications. 11: 807. PMID 32042044 DOI: 10.1038/S41467-020-14384-Z |
0.748 |
|
| 2019 |
Kim YC, Jung H, Seok S, Zhang Y, Ma J, Li T, Kemper B, Kemper JK. MicroRNA-210 promotes bile acid-induced cholestatic liver injury by targeting mixed-lineage leukemia-4 methyltransferase in mice. Hepatology (Baltimore, Md.). PMID 31549733 DOI: 10.1002/Hep.30966 |
0.412 |
|
| 2019 |
Shahoei SH, Kim YC, Cler SJ, Ma L, Anakk S, Kemper JK, Nelson ER. Small Heterodimer Partner regulates dichotomous T cell expansion by macrophages. Endocrinology. PMID 31050726 DOI: 10.1210/En.2019-00025 |
0.357 |
|
| 2019 |
Byun S, Jung H, Chen J, Kim YC, Kim DH, Kong B, Guo G, Kemper B, Kemper JK. Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. The Journal of Biological Chemistry. PMID 30996006 DOI: 10.1074/Jbc.Ra119.008360 |
0.548 |
|
| 2018 |
Kim YC, Byun S, Seok S, Guo G, Xu HE, Kemper B, Kemper JK. Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption. Gastroenterology. PMID 30521806 DOI: 10.1053/J.Gastro.2018.11.061 |
0.425 |
|
| 2018 |
Byun S, Kim DH, Ryerson D, Kim YC, Sun H, Kong B, Yau P, Guo G, Xu HE, Kemper B, Kemper JK. Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis. Nature Communications. 9: 2590. PMID 29968724 DOI: 10.1038/S41467-018-04697-5 |
0.751 |
|
| 2018 |
Seok S, Kim YC, Byun S, Choi S, Xiao Z, Iwamori N, Zhang Y, Wang C, Ma J, Ge K, Kemper B, Kemper JK. Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation. The Journal of Clinical Investigation. PMID 29911994 DOI: 10.1172/Jci97736 |
0.515 |
|
| 2018 |
Kim YC, Seok S, Byun S, Kong B, Zhang Y, Guo G, Xie W, Ma J, Kemper B, Kemper JK. AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. Nature Communications. 9: 540. PMID 29416063 DOI: 10.1038/S41467-018-03060-Y |
0.457 |
|
| 2017 |
Kwon S, Seok S, Yau P, Li X, Kemper B, Kemper JK. Obesity and aging diminish SIRT1-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. The Journal of Biological Chemistry. PMID 28808064 DOI: 10.1074/Jbc.M117.778720 |
0.696 |
|
| 2017 |
Choi SE, Kwon S, Seok S, Xiao Z, Lee KW, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and promotes fatty liver. Molecular and Cellular Biology. PMID 28533219 DOI: 10.1128/Mcb.00006-17 |
0.436 |
|
| 2017 |
Byun S, Kim YC, Zhang Y, Kong B, Guo G, Sadoshima J, Ma J, Kemper B, Kemper JK. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. The Embo Journal. PMID 28446510 DOI: 10.15252/Embj.201695500 |
0.541 |
|
| 2016 |
Kim DH, Kwon S, Byun S, Xiao Z, Park S, Wu SY, Chiang CM, Kemper B, Kemper JK. Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis. Nature Communications. 7: 12179. PMID 27412403 DOI: 10.1038/Ncomms12179 |
0.561 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Kemper JK, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.547 |
|
| 2016 |
Fu T, Kemper JK. MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity Vitamins and Hormones. DOI: 10.1016/Bs.Vh.2016.02.002 |
0.353 |
|
| 2015 |
Kim YC, Byun S, Zhang Y, Seok S, Kemper B, Ma J, Kemper JK. Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2. Genome Biology. 16: 268. PMID 26634251 DOI: 10.1186/S13059-015-0835-6 |
0.529 |
|
| 2015 |
Fu T, Kim YC, Byun S, Kim DH, Seok S, Suino-Powell K, Xu HE, Kemper B, Kemper JK. FXR primes the liver for intestinal FGF15 signaling by transient induction of βKlotho. Molecular Endocrinology (Baltimore, Md.). me20151226. PMID 26505219 DOI: 10.1210/Me.2015-1226 |
0.523 |
|
| 2015 |
Kim YC, Fang S, Byun S, Seok S, Kemper B, Kemper JK. Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity. Hepatology (Baltimore, Md.). 62: 220-31. PMID 25545350 DOI: 10.1002/Hep.27677 |
0.717 |
|
| 2015 |
Kim DH, Xiao Z, Kwon S, Sun X, Ryerson D, Tkac D, Ma P, Wu SY, Chiang CM, Zhou E, Xu HE, Palvimo JJ, Chen LF, Kemper B, Kemper JK. A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity. The Embo Journal. 34: 184-99. PMID 25425577 DOI: 10.15252/Embj.201489527 |
0.518 |
|
| 2014 |
Seok S, Fu T, Choi SE, Li Y, Zhu R, Kumar S, Sun X, Yoon G, Kang Y, Zhong W, Ma J, Kemper B, Kemper JK. Transcriptional regulation of autophagy by an FXR-CREB axis. Nature. 516: 108-11. PMID 25383523 DOI: 10.1038/Nature13949 |
0.527 |
|
| 2014 |
Fu T, Seok S, Choi S, Huang Z, Suino-Powell K, Xu HE, Kemper B, Kemper JK. MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Molecular and Cellular Biology. 34: 4130-42. PMID 25182532 DOI: 10.1128/Mcb.00596-14 |
0.331 |
|
| 2013 |
Choi SE, Kemper JK. Regulation of SIRT1 by microRNAs Molecules and Cells. 36: 385-392. PMID 24213676 DOI: 10.1007/S10059-013-0297-1 |
0.386 |
|
| 2013 |
Choi SE, Fu T, Seok S, Kim DH, Yu E, Lee KW, Kang Y, Li X, Kemper B, Kemper JK. Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell. 12: 1062-72. PMID 23834033 DOI: 10.1111/Acel.12135 |
0.343 |
|
| 2013 |
Seok S, Kanamaluru D, Xiao Z, Ryerson D, Choi SE, Suino-Powell K, Xu HE, Veenstra TD, Kemper JK. Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes. The Journal of Biological Chemistry. 288: 23252-63. PMID 23824184 DOI: 10.1074/Jbc.M113.452037 |
0.812 |
|
| 2013 |
Kemper JK, Choi SE, Kim DH. Sirtuin 1 Deacetylase. A Key Regulator of Hepatic Lipid Metabolism Vitamins and Hormones. 91: 385-404. PMID 23374725 DOI: 10.1016/B978-0-12-407766-9.00016-X |
0.548 |
|
| 2013 |
Smith Z, Ryerson D, Kemper JK. Epigenomic regulation of bile acid metabolism: Emerging role of transcriptional cofactors Molecular and Cellular Endocrinology. 368: 59-70. PMID 22579755 DOI: 10.1016/J.Mce.2012.04.008 |
0.61 |
|
| 2012 |
Fu T, Choi SE, Kim DH, Seok S, Suino-Powell KM, Xu HE, Kemper JK. Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho Proceedings of the National Academy of Sciences of the United States of America. 109: 16137-16142. PMID 22988100 DOI: 10.1073/Pnas.1205951109 |
0.395 |
|
| 2012 |
Yang Z, Zhang Y, Kemper JK, Wang L. Cross-regulation of protein stability by p53 and nuclear receptor SHP. Plos One. 7: e39789. PMID 22737255 DOI: 10.1371/Journal.Pone.0039789 |
0.388 |
|
| 2012 |
Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X. Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice. Molecular and Cellular Biology. 32: 1226-36. PMID 22290433 DOI: 10.1128/Mcb.05988-11 |
0.605 |
|
| 2012 |
Lee J, Seok S, Yu P, Kim K, Smith Z, Rivas-Astroza M, Zhong S, Kemper JK. Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology (Baltimore, Md.). 56: 108-17. PMID 22278336 DOI: 10.1002/Hep.25609 |
0.497 |
|
| 2011 |
Miao J, Choi SE, Seok SM, Yang L, Zuercher WJ, Xu Y, Willson TM, Xu HE, Kemper JK. Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Molecular Endocrinology (Baltimore, Md.). 25: 1159-69. PMID 21566081 DOI: 10.1210/Me.2011-0033 |
0.707 |
|
| 2011 |
Kanamaluru D, Xiao Z, Fang S, Choi SE, Kim DH, Veenstra TD, Kemper JK. Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. Molecular and Cellular Biology. 31: 1540-50. PMID 21262773 DOI: 10.1128/Mcb.01212-10 |
0.798 |
|
| 2011 |
Kemper JK. Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1812: 842-850. PMID 21130162 DOI: 10.1016/J.Bbadis.2010.11.011 |
0.577 |
|
| 2010 |
Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, Wu SY, Chiang CM, Veenstra TD, Kemper JK. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. The Journal of Biological Chemistry. 285: 33959-70. PMID 20817729 DOI: 10.1074/Jbc.M110.122978 |
0.799 |
|
| 2010 |
Lee J, Kemper JK. Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging. 2: 527-34. PMID 20689156 DOI: v2/n8/full/100184.html |
0.349 |
|
| 2010 |
Lee J, Padhye A, Sharma A, Song G, Miao J, Mo YY, Wang L, Kemper JK. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. The Journal of Biological Chemistry. 285: 12604-11. PMID 20185821 DOI: 10.1074/Jbc.M109.094524 |
0.566 |
|
| 2009 |
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metabolism. 10: 392-404. PMID 19883617 DOI: 10.1016/J.Cmet.2009.09.009 |
0.742 |
|
| 2009 |
Miao J, Fang S, Lee J, Comstock C, Knudsen KE, Kemper JK. Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis. Molecular and Cellular Biology. 29: 6170-81. PMID 19805516 DOI: 10.1128/Mcb.00825-09 |
0.793 |
|
| 2009 |
Miao J, Xiao Z, Kanamaluru D, Min G, Yau PM, Veenstra TD, Ellis E, Strom S, Suino-Powell K, Xu HE, Kemper JK. Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes & Development. 23: 986-96. PMID 19390091 DOI: 10.1101/Gad.1773909 |
0.767 |
|
| 2008 |
Fang S, Tsang S, Jones R, Ponugoti B, Yoon H, Wu SY, Chiang CM, Willson TM, Kemper JK. The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. The Journal of Biological Chemistry. 283: 35086-95. PMID 18842595 DOI: 10.1074/Jbc.M803531200 |
0.827 |
|
| 2007 |
Ponugoti B, Fang S, Kemper JK. Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Molecular Endocrinology (Baltimore, Md.). 21: 2698-712. PMID 17636037 DOI: 10.1210/Me.2007-0196 |
0.786 |
|
| 2007 |
Fang S, Miao J, Xiang L, Ponugoti B, Treuter E, Kemper JK. Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Molecular and Cellular Biology. 27: 1407-24. PMID 17145766 DOI: 10.1128/Mcb.00944-06 |
0.786 |
|
| 2006 |
Wu SY, Lee AY, Hou SY, Kemper JK, Erdjument-Bromage H, Tempst P, Chiang CM. Brd4 links chromatin targeting to HPV transcriptional silencing. Genes & Development. 20: 2383-96. PMID 16921027 DOI: 10.1101/Gad.1448206 |
0.353 |
|
| 2006 |
Zhang Q, Bae Y, Kemper JK, Kemper B. Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. Archives of Biochemistry and Biophysics. 451: 119-27. PMID 16725103 DOI: 10.1016/J.Abb.2006.04.016 |
0.322 |
|
| 2006 |
Miao J, Fang S, Bae Y, Kemper JK. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. The Journal of Biological Chemistry. 281: 14537-46. PMID 16492670 DOI: 10.1074/Jbc.M510713200 |
0.78 |
|
| 2004 |
Bhalla S, Ozalp C, Fang S, Xiang L, Kemper JK. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. The Journal of Biological Chemistry. 279: 45139-47. PMID 15322103 DOI: 10.1074/Jbc.M405423200 |
0.734 |
|
| 2004 |
Kemper JK, Kim H, Miao J, Bhalla S, Bae Y. Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP. Molecular and Cellular Biology. 24: 7707-19. PMID 15314177 DOI: 10.1128/Mcb.24.17.7707-7719.2004 |
0.708 |
|
| 2004 |
Bae Y, Kemper JK, Kemper B. Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). Dna and Cell Biology. 23: 81-91. PMID 15000748 DOI: 10.1089/104454904322759894 |
0.425 |
|
| 2003 |
Goodwin B, Watson MA, Kim H, Miao J, Kemper JK, Kliewer SA. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Molecular Endocrinology (Baltimore, Md.). 17: 386-94. PMID 12554795 DOI: 10.1210/Me.2002-0246 |
0.669 |
|
| 2002 |
Min G, Kim H, Bae Y, Petz L, Kemper JK. Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. The Journal of Biological Chemistry. 277: 34626-33. PMID 12114525 DOI: 10.1074/Jbc.M205239200 |
0.405 |
|
| 2002 |
Min G, Kemper JK, Kemper B. Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo. The Journal of Biological Chemistry. 277: 26356-63. PMID 12000748 DOI: 10.1074/Jbc.M200051200 |
0.317 |
|
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