| Year |
Citation |
Score |
| 2020 |
Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 30: 127501. PMID 32882418 DOI: 10.1016/J.Bmcl.2020.127501 |
0.312 |
|
| 2019 |
Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin L. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. The Journal of Pharmacology and Experimental Therapeutics. PMID 31413138 DOI: 10.1124/Jpet.119.258699 |
0.304 |
|
| 2019 |
Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of human DNA polymerases eta and kappa by indole-derived molecules occurs through distinct mechanisms. Acs Chemical Biology. PMID 31082191 DOI: 10.1021/Acschembio.9B00304 |
0.314 |
|
| 2019 |
Bommagani S, Penthala NR, Balasubramaniam M, Kuravi S, Caldas-Lopes E, Guzman ML, Balusu R, Crooks PA. A novel tetrazole analogue of resveratrol is a potent anticancer agent. Bioorganic & Medicinal Chemistry Letters. 29: 172-178. PMID 30528695 DOI: 10.1016/J.Bmcl.2018.12.006 |
0.383 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Crooks PA, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.557 |
|
| 2018 |
Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA. MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells. European Journal of Medicinal Chemistry. 157: 562-581. PMID 30121494 DOI: 10.1016/J.Ejmech.2018.08.010 |
0.344 |
|
| 2018 |
Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. The Aaps Journal. 20: 29. PMID 29427069 DOI: 10.1208/S12248-018-0192-Y |
0.331 |
|
| 2018 |
Zafar MK, Maddukuri L, Ketkar A, Penthala N, Reed MR, Eddy SD, Crooks PA, Eoff RL. A small-molecule inhibitor of human DNA polymerase eta potentiates the effects of cisplatin in tumor cells. Biochemistry. PMID 29345908 DOI: 10.1021/Acs.Biochem.7B01176 |
0.319 |
|
| 2017 |
Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 29153425 DOI: 10.1016/J.Bmcl.2017.10.039 |
0.327 |
|
| 2017 |
Walbaum A, Fifer EK, Parkin S, Crooks PA. Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 73: 864-866. PMID 28638646 DOI: 10.1107/S2056989017007277 |
0.353 |
|
| 2017 |
Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA. Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorganic & Medicinal Chemistry. PMID 28545815 DOI: 10.1016/J.Bmc.2017.05.008 |
0.366 |
|
| 2017 |
Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA. Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells. European Journal of Medicinal Chemistry. 136: 393-405. PMID 28525840 DOI: 10.1016/J.Ejmech.2017.05.031 |
0.349 |
|
| 2017 |
Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA. Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer agents. Anti-Cancer Agents in Medicinal Chemistry. PMID 28403783 DOI: 10.2174/1871521409666170412115703 |
0.738 |
|
| 2016 |
Albayati ZA, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorganic & Medicinal Chemistry. PMID 28049618 DOI: 10.1016/J.Bmc.2016.12.036 |
0.305 |
|
| 2016 |
Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. European Journal of Pharmacology. 795: 143-149. PMID 27986625 DOI: 10.1016/J.Ejphar.2016.12.016 |
0.309 |
|
| 2016 |
Laxmi SV, Anil P, Rajitha G, Rao AJ, Crooks PA, Rajitha B. Synthesis of thiazolidine-2,4-dione derivatives: anticancer, antimicrobial and DNA cleavage studies. Journal of Chemical Biology. 9: 97-106. PMID 27698947 DOI: 10.1007/S12154-016-0154-8 |
0.33 |
|
| 2016 |
Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27524311 DOI: 10.1016/J.Bmcl.2016.08.001 |
0.32 |
|
| 2016 |
Penthala NR, Yadlapalli JK, Parkin S, Crooks PA. Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallographica. Section E, Crystallographic Communications. 72: 652-5. PMID 27308011 DOI: 10.1107/S2056989016005600 |
0.321 |
|
| 2016 |
Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27212067 DOI: 10.1016/J.Bmcl.2016.05.025 |
0.337 |
|
| 2016 |
Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27080180 DOI: 10.1016/J.Bmcl.2016.03.119 |
0.319 |
|
| 2016 |
Madadi NR, Ketkar A, Penthala NR, Bostian AC, Eoff RL, Crooks PA. Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 27017113 DOI: 10.1016/J.Bmcl.2016.03.068 |
0.73 |
|
| 2016 |
Penthala NR, Bommagani S, Yadlapalli J, Crooks PA. A novel and efficient tributyltin azide-mediated synthesis of 1H-tetrazolylstilbenes from cyanostilbenes Tetrahedron Letters. 57: 1807-1810. DOI: 10.1016/J.Tetlet.2016.03.040 |
0.331 |
|
| 2015 |
Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents. Medchemcomm. 6: 1535-1543. PMID 27066215 DOI: 10.1039/C5Md00219B |
0.744 |
|
| 2015 |
Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorganic & Medicinal Chemistry. PMID 26602084 DOI: 10.1016/J.Bmc.2015.10.019 |
0.348 |
|
| 2015 |
Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1147-50. PMID 26594393 DOI: 10.1107/S2056989015016163 |
0.336 |
|
| 2015 |
Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1132-5. PMID 26594389 DOI: 10.1107/S2056989015015352 |
0.334 |
|
| 2015 |
Crooks PA, Janganati V, Ponder J, Jordan CT, Borrelli MJ, Penthala NR. Dimers of melampomagnolide B exhibit potent anticancer activity against hematological and solid tumor cells. Journal of Medicinal Chemistry. PMID 26540463 DOI: 10.1021/Acs.Jmedchem.5B01187 |
0.34 |
|
| 2015 |
Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. European Journal of Medicinal Chemistry. 103: 123-32. PMID 26352674 DOI: 10.1016/J.Ejmech.2015.08.041 |
0.747 |
|
| 2015 |
Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm. 6: 788-794. PMID 26257861 DOI: 10.1039/C4Md00478G |
0.73 |
|
| 2015 |
Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochemical Research. PMID 26227997 DOI: 10.1007/S11064-015-1680-4 |
0.318 |
|
| 2015 |
Penthala NR, Thakkar S, Crooks PA. Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 25: 2763-7. PMID 26022840 DOI: 10.1016/J.Bmcl.2015.05.019 |
0.343 |
|
| 2015 |
Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: Novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. 25: 2613-6. PMID 25991431 DOI: 10.1016/J.Bmcl.2015.04.105 |
0.333 |
|
| 2015 |
Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents. European Journal of Medicinal Chemistry. 92: 212-20. PMID 25557492 DOI: 10.1016/J.Ejmech.2014.12.050 |
0.738 |
|
| 2015 |
Gali R, Banothu J, Gondru R, Bavantula R, Velivela Y, Crooks PA. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorganic & Medicinal Chemistry Letters. 25: 106-12. PMID 25435148 DOI: 10.1016/J.Bmcl.2014.10.100 |
0.336 |
|
| 2015 |
Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents Medchemcomm. 6: 1535-1543. DOI: 10.1039/c5md00219b |
0.694 |
|
| 2015 |
Penthala NR, Madadi NR, Janganati V, Crooks PA. ChemInform Abstract: L-Proline Catalyzed One-Step Synthesis of 4,5-Diaryl-2H-1,2,3-triazoles from Heteroaryl Cyanostilbenes via [3 + 2]Cycloaddition of Azide. Cheminform. 46: no-no. DOI: 10.1002/CHIN.201511180 |
0.703 |
|
| 2015 |
Madadi NR, Crooks PA. Anticancer Evaluation of 3,4,5,4'-trans-tetramethoxystilbene (DMU-212) and Its Analogs Against an Extensive Panel of Human Tumor Cell Lines Letters in Drug Design and Discovery. 12: 521-528. |
0.704 |
|
| 2014 |
Penthala NR, Madadi NR, Bommagani S, Parkin S, Crooks PA. Comparison of crystal structures of 4-(benzo[b]thio-phen-2-yl)-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole and 4-(benzo[b]thio-phen-2-yl)-2-methyl-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole. Acta Crystallographica. Section E, Structure Reports Online. 70: 392-5. PMID 25484755 DOI: 10.1107/S1600536814023095 |
0.731 |
|
| 2014 |
Madadi NR, Penthala NR, Bommagani S, Parkin S, Crooks PA. Crystal structure of 4,5-bis-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole methanol monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o1128-9. PMID 25484710 DOI: 10.1107/S1600536814020911 |
0.727 |
|
| 2014 |
Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]phen-yl}parthenolide methanol hemisolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o1092-3. PMID 25484689 DOI: 10.1107/S1600536814019333 |
0.342 |
|
| 2014 |
Penthala NR, Madadi NR, Janganati V, Crooks PA. L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide. Tetrahedron Letters. 55: 5562-5565. PMID 25267862 DOI: 10.1016/J.Tetlet.2014.08.027 |
0.728 |
|
| 2014 |
Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. European Journal of Medicinal Chemistry. 85: 517-25. PMID 25117652 DOI: 10.1016/J.Ejmech.2014.08.022 |
0.733 |
|
| 2014 |
Janganati V, Penthala NR, Madadi NR, Chen Z, Crooks PA. Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorganic & Medicinal Chemistry Letters. 24: 3499-502. PMID 24928404 DOI: 10.1016/J.Bmcl.2014.05.059 |
0.726 |
|
| 2014 |
Franks LN, Ford BM, Madadi NR, Penthala NR, Crooks PA, Prather PL. Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs. European Journal of Pharmacology. 737: 140-8. PMID 24858620 DOI: 10.1016/J.Ejphar.2014.05.007 |
0.716 |
|
| 2014 |
Janganati V, Penthala NR, Madadi NR, Parkin S, Crooks PA. Monosuccinate ester of melampomagnolide B. Acta Crystallographica. Section E, Structure Reports Online. 70: o372-3. PMID 24765054 DOI: 10.1107/S1600536814002815 |
0.716 |
|
| 2014 |
Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. (E)-13-(2-Bromo-phen-yl)micheliolide. Acta Crystallographica. Section E, Structure Reports Online. 70: o251-2. PMID 24764970 DOI: 10.1107/S1600536814002177 |
0.317 |
|
| 2014 |
Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA. Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorganic & Medicinal Chemistry Letters. 24: 1963-7. PMID 24656611 DOI: 10.1016/J.Bmcl.2014.02.067 |
0.301 |
|
| 2014 |
Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chemical Research in Toxicology. 27: 536-45. PMID 24571610 DOI: 10.1021/Tx400408X |
0.722 |
|
| 2014 |
Crooks PA, Bardo MT, Dwoskin LP. Nicotinic receptor antagonists as treatments for nicotine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 513-51. PMID 24484986 DOI: 10.1016/B978-0-12-420118-7.00013-5 |
0.303 |
|
| 2014 |
Madadi NR, Penthala NR, Janganati V, Crooks PA. Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines. Bioorganic & Medicinal Chemistry Letters. 24: 601-3. PMID 24361000 DOI: 10.1016/J.Bmcl.2013.12.013 |
0.753 |
|
| 2014 |
Penthala NR, Janganati V, Bommagani S, Crooks PA. Synthesis and evaluation of a series of quinolinyl trans-cyanostilbene analogs as anticancer agents Med. Chem. Commun.. 5: 886-890. DOI: 10.1039/C4Md00115J |
0.317 |
|
| 2014 |
Madadi NR, Penthala NR, Song L, Hendrickson HP, Crooks PA. Preparation of 4,5 disubstituted-2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles Tetrahedron Letters. 55: 4207-4211. DOI: 10.1016/J.Tetlet.2014.05.045 |
0.722 |
|
| 2014 |
Madadi NR, Penthala NR, Song L, Hendrickson HP, Crooks PA. ChemInform Abstract: Preparation of 4,5-Disubstituted-2H-1,2,3-triazoles from (Z)-2,3-Diaryl Substituted Acrylonitriles. Cheminform. 45: no-no. DOI: 10.1002/CHIN.201452135 |
0.705 |
|
| 2013 |
Bommagani S, Penthala NR, Janganati V, Parkin S, Crooks PA. 13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate. Acta Crystallographica. Section E, Structure Reports Online. 69: o1789-90. PMID 24454230 DOI: 10.1107/S1600536813030304 |
0.323 |
|
| 2013 |
Janganati V, Penthala NR, Parkin S, Crooks PA. 13-(Imidazol-1-yl)-11,13-di-hydro-melampomagnolide B monohydrate. Acta Crystallographica. Section E, Structure Reports Online. 69: o1734-5. PMID 24454194 DOI: 10.1107/S1600536813029188 |
0.321 |
|
| 2013 |
Penthala NR, Janganati V, Parkin S, Varughese KI, Crooks PA. (E)-13-(4-Amino-phen-yl)parthenolide. Acta Crystallographica. Section E, Structure Reports Online. 69: o1709-10. PMID 24454134 DOI: 10.1107/S1600536813028730 |
0.327 |
|
| 2013 |
Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorganic & Medicinal Chemistry. 21: 6771-7. PMID 23993667 DOI: 10.1016/J.Bmc.2013.08.001 |
0.329 |
|
| 2013 |
Penthala NR, Sonar VN, Horn J, Leggas M, Yadlapalli JS, Crooks PA. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Medchemcomm. 4: 1073-1078. PMID 23956835 DOI: 10.1039/C3Md00130J |
0.322 |
|
| 2013 |
Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. Acs Chemical Biology. 8: 1722-9. PMID 23679919 DOI: 10.1021/Cb400305R |
0.321 |
|
| 2013 |
Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorganic & Medicinal Chemistry Letters. 23: 3342-5. PMID 23597792 DOI: 10.1016/J.Bmcl.2013.03.092 |
0.321 |
|
| 2013 |
Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 4: 564-568. PMID 23527317 DOI: 10.1039/C3Md20374C |
0.351 |
|
| 2013 |
Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorganic & Medicinal Chemistry Letters. 23: 2019-21. PMID 23466226 DOI: 10.1016/J.Bmcl.2013.02.025 |
0.729 |
|
| 2013 |
Ring JR, Zheng F, Haubner AJ, Littleton JM, Crooks PA. Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study. Bioorganic & Medicinal Chemistry. 21: 1764-74. PMID 23465801 DOI: 10.1016/J.Bmc.2013.01.051 |
0.774 |
|
| 2013 |
Penthala NR, Crooks PA. rac-N-Benzyl-isatincreatinine (unknown solvate). Acta Crystallographica. Section E, Structure Reports Online. 69: o290-1. PMID 23424560 DOI: 10.1107/S1600536813000378 |
0.332 |
|
| 2013 |
Penthala NR, Crooks PA. rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 69: o288-9. PMID 23424559 DOI: 10.1107/S160053681300038X |
0.321 |
|
| 2013 |
Penthala NR, Ponugoti PR, Kasam V, Crooks PA. 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. Bioorganic & Medicinal Chemistry Letters. 23: 1442-6. PMID 23339966 DOI: 10.1016/J.Bmcl.2012.12.053 |
0.364 |
|
| 2013 |
Penthala NR, Yerramreddy TR, Parkin S, Crooks PA. Solvent-Specific C―N Bond Formation: Synthesis of Novel Ninhydrin-Creatinine Heterocyclic Condensation Products Journal of Heterocyclic Chemistry. 50: E156-E159. DOI: 10.1002/Jhet.1107 |
0.347 |
|
| 2012 |
Penthala NR, Ponugoti PR, Parkin S, Crooks PA. rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate. Acta Crystallographica. Section E, Structure Reports Online. 68: o3111. PMID 23284437 DOI: 10.1107/S1600536812040731 |
0.339 |
|
| 2012 |
Sonar VN, Parkin S, Crooks PA. Oxycodone N-oxide. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o436-8. PMID 23124457 DOI: 10.1107/S0108270112040188 |
0.315 |
|
| 2012 |
Sonar VN, Parkin S, Crooks PA. The effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o405-7. PMID 23007543 DOI: 10.1107/S0108270112038322 |
0.315 |
|
| 2012 |
Barron S, Lewis B, Wellmann K, Carter M, Farook J, Ring J, Rogers DT, Holley R, Crooks P, Littleton J. Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence. Recent Patents On Cns Drug Discovery. 7: 129-44. PMID 22574674 DOI: 10.2174/157488912800673128 |
0.312 |
|
| 2012 |
Penthala NR, Parkin S, Crooks PA. (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-tri-meth-oxy-phen-yl)acrylonitrile. Acta Crystallographica. Section E, Structure Reports Online. 68: o731. PMID 22412613 DOI: 10.1107/S1600536812005831 |
0.31 |
|
| 2012 |
Madadi NR, Parkin S, Crooks PA. (Z)-2-{2,4-Dimeth-oxy-6-[(E)-4-meth-oxy-styr-yl]benzyl-idene}quinuclidin-3-one. Acta Crystallographica. Section E, Structure Reports Online. 68: o730. PMID 22412612 DOI: 10.1107/S1600536812005843 |
0.726 |
|
| 2012 |
Penthala NR, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile. Acta Crystallographica. Section E, Structure Reports Online. 68: o729. PMID 22412611 DOI: 10.1107/S1600536812005855 |
0.33 |
|
| 2011 |
Zhang Z, Dwoskin LP, Crooks PA. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition. Tetrahedron Letters. 52: 2667-2669. PMID 23908558 DOI: 10.1016/J.Tetlet.2011.03.065 |
0.314 |
|
| 2011 |
Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 339: 286-97. PMID 21778282 DOI: 10.1124/Jpet.111.184770 |
0.344 |
|
| 2011 |
Nasim S, Guzman ML, Jordan CT, Crooks PA. Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture. Bioorganic & Medicinal Chemistry Letters. 21: 4879-83. PMID 21757349 DOI: 10.1016/J.Bmcl.2011.06.027 |
0.309 |
|
| 2011 |
Biermann M, Hardcastle KI, Moskalev NV, Crooks PA. (S)-2-Amino-2-(2-chloro-phen-yl)cyclo-hexa-none. Acta Crystallographica. Section E, Structure Reports Online. 67: o936. PMID 21754205 DOI: 10.1107/S1600536811009950 |
0.323 |
|
| 2011 |
Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile. Acta Crystallographica. Section E, Structure Reports Online. 67: o747. PMID 21754044 DOI: 10.1107/S1600536811006258 |
0.323 |
|
| 2011 |
Vijaya Laxmi S, Thirupathi Reddy Y, Suresh Kuarm B, Narsimha Reddy P, Crooks PA, Rajitha B. Synthesis and evaluation of chromenyl barbiturates and thiobarbiturates as potential antitubercular agents. Bioorganic & Medicinal Chemistry Letters. 21: 4329-31. PMID 21684158 DOI: 10.1016/J.Bmcl.2011.05.055 |
0.323 |
|
| 2011 |
Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate. Acta Crystallographica. Section E, Structure Reports Online. 67: o737. PMID 21522476 DOI: 10.1107/S1600536811006143 |
0.327 |
|
| 2011 |
Hojahmat M, Zheng G, Siegler M, Parkin S, Biermann M, Crooks PA. (S)-1-(2-Chloro-phen-yl)-2-oxocyclo-hexan-1-aminium d-tartrate. Acta Crystallographica. Section E, Structure Reports Online. 67: o736. PMID 21522475 DOI: 10.1107/S1600536811006131 |
0.323 |
|
| 2011 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. (2Z,3E)-2-{[1-(4-Chloro-benz-yl)-1H-indol-3-yl]methyl-idene}quinuclidin-3-one oxime. Acta Crystallographica. Section E, Structure Reports Online. 67: o735. PMID 21522474 DOI: 10.1107/S160053681100612X |
0.351 |
|
| 2011 |
Pivavarchyk M, Smith AM, Zhang Z, Zhou D, Wang X, Toyooka N, Tsuneki H, Sasaoka T, McIntosh JM, Crooks PA, Dwoskin LP. Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release. European Journal of Pharmacology. 658: 132-9. PMID 21371454 DOI: 10.1016/J.Ejphar.2011.02.018 |
0.333 |
|
| 2011 |
Penthala NR, Yerramreddy TR, Crooks PA. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 1411-3. PMID 21295476 DOI: 10.1016/J.Bmcl.2011.01.020 |
0.381 |
|
| 2011 |
Wooters TE, Smith AM, Pivavarchyk M, Siripurapu KB, McIntosh JM, Zhang Z, Crooks PA, Bardo MT, Dwoskin LP. bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse. British Journal of Pharmacology. 163: 346-57. PMID 21232049 DOI: 10.1111/J.1476-5381.2011.01220.X |
0.314 |
|
| 2011 |
Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 336: 940-51. PMID 21177475 DOI: 10.1124/Jpet.110.175117 |
0.302 |
|
| 2011 |
Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 21: 88-91. PMID 21147530 DOI: 10.1016/J.Bmcl.2010.11.070 |
0.321 |
|
| 2011 |
Kuarm BS, Reddy YT, Madhav JV, Crooks PA, Rajitha B. 3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents. Bioorganic & Medicinal Chemistry Letters. 21: 524-7. PMID 21134751 DOI: 10.1016/J.Bmcl.2010.10.082 |
0.304 |
|
| 2011 |
Crooks PA, Zheng G, Vartak AP, Culver JP, Zheng F, Horton DB, Dwoskin LP. Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Current Topics in Medicinal Chemistry. 11: 1103-27. PMID 21050177 DOI: 10.2174/156802611795371332 |
0.305 |
|
| 2011 |
Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2. The Journal of Pharmacology and Experimental Therapeutics. 336: 724-33. PMID 20876747 DOI: 10.1124/Jpet.110.172882 |
0.356 |
|
| 2011 |
Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. International Journal of Cancer. Journal International Du Cancer. 128: 2481-94. PMID 20669221 DOI: 10.1002/Ijc.25587 |
0.305 |
|
| 2011 |
Zong H, Penthala NR, Sen S, Brennan S, Sonar V, Crooks PA, Guzman ML. The Acrylonitrile Analog, VJ-289 Ablates Acute Myelogenous Leukemia Blast, Progenitor and Stem Cell Populations by Inducing Tubulin Acetylation and Caspase Activation Blood. 118: 2496-2496. DOI: 10.1182/Blood.V118.21.2496.2496 |
0.307 |
|
| 2011 |
Leggas M, Tsakalozou E, Ahmed T, Kuo K, Horn J, Penthala N, Crooks P. Abstract C216: Small molecule antitubulin drugs that evade multiple drug resistance mechanisms. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C216 |
0.305 |
|
| 2010 |
Penthala NR, Eldridge J, Reddy TR, Parkin S, Crooks PA. (E,E)-1-Methyl-2,6-distyrylpyridinium iodide. Acta Crystallographica. Section E, Structure Reports Online. 66: o1793. PMID 21588003 DOI: 10.1107/S1600536810018519 |
0.331 |
|
| 2010 |
Madadi NR, Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-2-Amino-5-[2,4-dimeth-oxy-6-(4-methoxy-styr-yl)benzyl-idene]-1,3-thia-zol-4(5H)-one methanol solvate. Acta Crystallographica. Section E, Structure Reports Online. 66: o1792. PMID 21588002 DOI: 10.1107/S1600536810018520 |
0.73 |
|
| 2010 |
Venkateswaran A, Reddy YT, Sonar VN, Muthusamy V, Crooks PA, Freeman ML, Sekhar KR. Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives. Bioorganic & Medicinal Chemistry Letters. 20: 7323-6. PMID 21055930 DOI: 10.1016/J.Bmcl.2010.10.060 |
0.349 |
|
| 2010 |
Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 335: 841-51. PMID 20805303 DOI: 10.1124/Jpet.110.172742 |
0.326 |
|
| 2010 |
Penthala NR, Yerramreddy TR, Madadi NR, Crooks PA. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4468-71. PMID 20598531 DOI: 10.1016/J.Bmcl.2010.06.042 |
0.741 |
|
| 2010 |
Thirupathi Reddy Y, Narsimha Reddy P, Koduru S, Damodaran C, Crooks PA. Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones. Bioorganic & Medicinal Chemistry. 18: 3570-4. PMID 20403701 DOI: 10.1016/J.Bmc.2010.03.054 |
0.359 |
|
| 2010 |
Smith AM, Pivavarchyk M, Wooters TE, Zhang Z, Zheng G, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochemical Pharmacology. 80: 402-9. PMID 20346923 DOI: 10.1016/J.Bcp.2010.03.018 |
0.307 |
|
| 2010 |
Zhang Z, Pivavarchyk M, Subramanian KL, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 20: 1420-3. PMID 20079634 DOI: 10.1016/J.Bmcl.2009.12.089 |
0.339 |
|
| 2010 |
Geldenhuys WJ, Manda VK, Mittapalli RK, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD, Lockman PR. Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 20: 870-7. PMID 20053562 DOI: 10.1016/J.Bmcl.2009.12.079 |
0.303 |
|
| 2010 |
Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorganic & Medicinal Chemistry. 18: 640-9. PMID 20036131 DOI: 10.1016/J.Bmc.2009.12.002 |
0.307 |
|
| 2010 |
Penthala NR, Yerramreddy TR, Crooks PA. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines. Bioorganic & Medicinal Chemistry Letters. 20: 591-3. PMID 20006496 DOI: 10.1016/J.Bmcl.2009.11.083 |
0.38 |
|
| 2010 |
Reddy YT, Sekhar KR, Sasi N, Reddy PN, Freeman ML, Crooks PA. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents Bioorganic and Medicinal Chemistry Letters. 20: 600-602. PMID 20005706 DOI: 10.1016/J.Bmcl.2009.11.082 |
0.352 |
|
| 2010 |
Bence AK, Crooks PA. ChemInform Abstract: Synthesis of L-Indospicine. Cheminform. 33: no-no. DOI: 10.1002/chin.200248191 |
0.716 |
|
| 2009 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. rac-2-(2-Amino-4-oxo-4,5-dihydro-1,3-thia-zol-5-yl)-2-hydroxy-indane-1,3-dione. Acta Crystallographica. Section E, Structure Reports Online. 65: o1877. PMID 21583571 DOI: 10.1107/S1600536809025574 |
0.33 |
|
| 2009 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydroxy-indolin-2-one monohydrate. Acta Crystallographica. Section E, Structure Reports Online. 65: o552. PMID 21582211 DOI: 10.1107/S1600536809004875 |
0.344 |
|
| 2009 |
Zheng G, Parkin S, Dwoskin LP, Crooks PA. (2S,6S)-1-Methyl-2,6-trans-distyryl-piperidinium chloride. Acta Crystallographica. Section E, Structure Reports Online. 66: o78. PMID 21580177 DOI: 10.1107/S1600536809049587 |
0.331 |
|
| 2009 |
Zheng G, Parkin S, Dwoskin LP, Crooks PA. 1-Methyl-2,6-cis-distyrylpiperidine. Acta Crystallographica. Section E, Structure Reports Online. 66: o77. PMID 21580176 DOI: 10.1107/S1600536809049617 |
0.326 |
|
| 2009 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-5-fluoro-3-hydr-oxy-1-methyl-indolin-2-one methanol hemisolvate. Acta Crystallographica. Section E, Structure Reports Online. 65: o2909-10. PMID 21578489 DOI: 10.1107/S1600536809043797 |
0.323 |
|
| 2009 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydr-oxy-1-phenyl-indolin-2-one ethanol solvate. Acta Crystallographica. Section E, Structure Reports Online. 65: o2439-40. PMID 21577895 DOI: 10.1107/S1600536809033881 |
0.353 |
|
| 2009 |
Worthen DR, Bence AK, Stables JP, Crooks PA. In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorganic & Medicinal Chemistry Letters. 19: 5012-5. PMID 19632831 DOI: 10.1016/J.Bmcl.2009.07.059 |
0.741 |
|
| 2009 |
Smith AM, Dhawan GK, Zhang Z, Siripurapu KB, Crooks PA, Dwoskin LP. The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. Biochemical Pharmacology. 78: 889-97. PMID 19631612 DOI: 10.1016/J.Bcp.2009.07.010 |
0.315 |
|
| 2009 |
López-Hernández GY, Thinschmidt JS, Zheng G, Zhang Z, Crooks PA, Dwoskin LP, Papke RL. Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists. Molecular Pharmacology. 76: 652-66. PMID 19556356 DOI: 10.1124/Mol.109.056176 |
0.317 |
|
| 2009 |
Neelakantan S, Nasim S, Guzman ML, Jordan CT, Crooks PA. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorganic & Medicinal Chemistry Letters. 19: 4346-9. PMID 19505822 DOI: 10.1016/J.Bmcl.2009.05.092 |
0.328 |
|
| 2009 |
Zheng F, McConnell MJ, Zhan CG, Dwoskin LP, Crooks PA. QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorganic & Medicinal Chemistry. 17: 4477-85. PMID 19477134 DOI: 10.1016/J.Bmc.2009.05.010 |
0.325 |
|
| 2009 |
Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 157-68. PMID 18629679 DOI: 10.1080/14756360801945648 |
0.312 |
|
| 2009 |
Sonar VN, Crooks PA. Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 117-124. PMID 18629678 DOI: 10.1080/14756360801915526 |
0.329 |
|
| 2009 |
Hassane D, Sen S, Corbett CA, Balys M, Rossi RM, Crooks PA, Guzman ML, Jordan CT. Chemical Genomic Screening Reveals That PI3K/mTOR Inhibition Enhances Activity of the Anti-Leukemia Stem Cell Compound Parthenolide. Blood. 114: 388-388. DOI: 10.1182/Blood.V114.22.388.388 |
0.321 |
|
| 2009 |
Guzman ML, Nasim S, Balys M, Corbett CA, Crooks PA, Jordan CT. Chemical Derivatives of the Anti-Leukemia Stem Cell Compound 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione (TDZD-8) with Improved Activity. Blood. 114: 3764-3764. DOI: 10.1182/Blood.V114.22.3764.3764 |
0.341 |
|
| 2009 |
Pei S, Guzman ML, Nasim S, Shi L, Crooks PA, Jordan CT. Analysis of the Anti-Leukemia Mechanism of Parthenolide. Blood. 114: 2734-2734. DOI: 10.1182/Blood.V114.22.2734.2734 |
0.319 |
|
| 2008 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-Methyl 4-({3-[(2,5-dioxoimidazolidin-4-yl-idene)meth-yl]-1H-indol-1-yl}meth-yl)benzoate. Acta Crystallographica. Section E, Structure Reports Online. 65: o62-3. PMID 21581703 DOI: 10.1107/S1600536808041020 |
0.329 |
|
| 2008 |
Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-4-[3-(2,5-Dioxoimidazolidin-4-ylidenemeth-yl)-1H-indol-1-ylmeth-yl]benzonitrile. Acta Crystallographica. Section E, Structure Reports Online. 64: o2122. PMID 21580984 DOI: 10.1107/S1600536808032601 |
0.343 |
|
| 2008 |
Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-Methyl 4-[3-(3-oxoquinuclidin-2-yl-idenemeth-yl)-1H-indol-1-ylmeth-yl]benzoate. Acta Crystallographica. Section E, Structure Reports Online. 64: o2050. PMID 21580918 DOI: 10.1107/S1600536808030018 |
0.356 |
|
| 2008 |
Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-4-[3-(3-Oxoquinuclidin-2-ylidene-meth-yl)-1H-indol-1-ylmeth-yl]benzo-nitrile. Acta Crystallographica. Section E, Structure Reports Online. 64: o2049. PMID 21580917 DOI: 10.1107/S1600536808030006 |
0.349 |
|
| 2008 |
Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. 18: 6509-12. PMID 18976906 DOI: 10.1016/J.Bmcl.2008.10.042 |
0.325 |
|
| 2008 |
Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 18: 5753-7. PMID 18851914 DOI: 10.1016/J.Bmcl.2008.09.084 |
0.323 |
|
| 2008 |
Zhang Z, Lockman PR, Mittapalli RK, Allen DD, Dwoskin LP, Crooks PA. bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 18: 5622-5. PMID 18793853 DOI: 10.1016/J.Bmcl.2008.08.099 |
0.323 |
|
| 2008 |
Nasim S, Crooks PA. Antileukemic activity of aminoparthenolide analogs Bioorganic and Medicinal Chemistry Letters. 18: 3870-3873. PMID 18590961 DOI: 10.1016/J.Bmcl.2008.06.050 |
0.331 |
|
| 2008 |
Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity. The Journal of Pharmacology and Experimental Therapeutics. 326: 563-76. PMID 18460644 DOI: 10.1124/Jpet.108.136630 |
0.33 |
|
| 2008 |
Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. The Journal of Organic Chemistry. 73: 3497-507. PMID 18363376 DOI: 10.1021/Jo800028Q |
0.356 |
|
| 2008 |
Lockman PR, Manda VK, Geldenhuys WJ, Mittapalli RK, Thomas F, Albayati ZF, Crooks PA, Dwoskin LP, Allen DD. Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier. The Journal of Pharmacology and Experimental Therapeutics. 324: 244-50. PMID 17921191 DOI: 10.1124/Jpet.107.130906 |
0.332 |
|
| 2008 |
Reddy YT, Reddy PN, Crooks PA, De Clercq E, Rao GVP, Rajitha B. SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SUBSTITUTED N1-[1-BENZYL-3-(3-TERT-BUTYLCARBAMOYL-OCTAHYDROISOQUINOLIN-2YL)-2-HYDROXY- PROPYL]-2-[(2-OXO-2H-CHROMENE-3-CARBONYL) AMINO] SUCCINAMIDE ANALOGS AS ΑΝΤΙ-VIRAL AND ΑΝΤΙ-HIV AGENTS Heterocyclic Communications. 14. DOI: 10.1515/Hc.2008.14.6.419 |
0.315 |
|
| 2007 |
Zheng G, Zhang Z, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation. Bioorganic & Medicinal Chemistry Letters. 17: 6734-8. PMID 18029180 DOI: 10.1016/J.Bmcl.2007.10.052 |
0.326 |
|
| 2007 |
Sonar VN, Thirupathi Reddy Y, Sekhar KR, Sasi S, Freeman ML, Crooks PA. Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents Bioorganic and Medicinal Chemistry Letters. 17: 6821-6824. PMID 17980582 DOI: 10.1016/J.Bmcl.2007.10.035 |
0.331 |
|
| 2007 |
Zheng G, Sumithran SP, Deaciuc AG, Dwoskin LP, Crooks PA. Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 17: 6701-6. PMID 17977723 DOI: 10.1016/J.Bmcl.2007.10.062 |
0.331 |
|
| 2007 |
Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, ... Crooks PA, et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 110: 4427-35. PMID 17804695 DOI: 10.1182/Blood-2007-05-090621 |
0.309 |
|
| 2007 |
Dwoskin LP, Joyce BM, Zheng G, Neugebauer NM, Manda VK, Lockman P, Papke RL, Bardo MT, Crooks PA. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochemical Pharmacology. 74: 1271-82. PMID 17727820 DOI: 10.1016/J.Bcp.2007.07.021 |
0.329 |
|
| 2007 |
Sonar VN, Venkatraj M, Parkin S, Crooks PA. rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol. Acta Crystallographica. Section C, Crystal Structure Communications. 63: o493-5. PMID 17675705 DOI: 10.1107/S0108270107033690 |
0.31 |
|
| 2007 |
Ring JR, Parkin S, Crooks PA. (4-Meth-oxy-3-nitro-benzyl-idene-amino)-guanidinium chloride Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 17609569 DOI: 10.1107/S0108270107023475 |
0.304 |
|
| 2007 |
Sonar VN, Venkatraj M, Parkin S, Crooks PA. (Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone. Acta Crystallographica. Section C, Crystal Structure Communications. 63: o277-9. PMID 17478911 DOI: 10.1107/S0108270107006129 |
0.326 |
|
| 2007 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethyl-ene)-1-aza-bicyclo-[2.2.2] octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 17284808 DOI: 10.1107/S0108270106055971 |
0.322 |
|
| 2007 |
Middleton LS, Crooks PA, Wedlund PJ, Cass WA, Dwoskin LP. Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation. Synapse (New York, N.Y.). 61: 157-65. PMID 17146768 DOI: 10.1002/Syn.20351 |
0.3 |
|
| 2007 |
Nasim S, Parkin S, Crooks PA. (11R)-13-(1-Naphthylmethylamino)-4,5-epoxy-11,13-dihydrocostunolide Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807046983 |
0.321 |
|
| 2007 |
Sonar VN, Parkin S, Crooks PA. (Z)-3-[1-(4-Chloro-benz-yl)-1H-indol-3-yl]-2-(3-thien-yl)acrylonitrile Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807042638 |
0.332 |
|
| 2007 |
Sonar VN, Parkin S, Crooks PA. Rac-(Z)-2-(1-Naphthyl-methyl-ene)-1-aza-bicyclo-[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041682 |
0.309 |
|
| 2007 |
Sonar VN, Parkin S, Crooks PA. Rac-(Z)-2-(2,4-Dichloro-benzyl-idene)-1-aza-bicyclo-[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041128 |
0.306 |
|
| 2007 |
Sonar VN, Neelakantan S, Siegler M, Crooks PA. (E)-1-[(2-Methoxyphenyl)methyleneamino]-guanidinium chloride Acta Crystallographica Section E: Structure Reports Online. 63: o535-o536. DOI: 10.1107/S1600536806055383 |
0.306 |
|
| 2006 |
Chen J, Deaciuc AG, Dwoskin LP, Crooks PA, Bai D. N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors. Journal of Enzyme Inhibition and Medicinal Chemistry. 21: 667-80. PMID 17252939 DOI: 10.1080/14756360600900513 |
0.331 |
|
| 2006 |
Sonar VN, Parkin S, Crooks PA. 1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide Acta Crystallographica Section C: Crystal Structure Communications. 62. PMID 16518054 DOI: 10.1107/S0108270106003441 |
0.328 |
|
| 2006 |
Chandrasekaran S, Al-Ghananeem AM, Riggs RM, Crooks PA. Synthesis and stability of two indomethacin prodrugs. Bioorganic & Medicinal Chemistry Letters. 16: 1874-9. PMID 16439128 DOI: 10.1016/J.Bmcl.2006.01.003 |
0.301 |
|
| 2006 |
Zheng F, Bayram E, Sumithran SP, Ayers JT, Zhan CG, Schmitt JD, Dwoskin LP, Crooks PA. QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release. Bioorganic & Medicinal Chemistry. 14: 3017-37. PMID 16431111 DOI: 10.1016/J.Bmc.2005.12.036 |
0.327 |
|
| 2006 |
Guzman ML, Rossi RM, Li X, Corbett C, Hassane DC, Bushnell T, Carroll M, Sullivan E, Neelakantan S, Crooks PA, Jordan CT. A Novel Orally Available Parthenolide Analog Selectively Eradicates AML Stem and Progenitor Cells. Blood. 108: 237-237. DOI: 10.1182/Blood.V108.11.237.237 |
0.325 |
|
| 2006 |
Sonar VN, Venkataraj M, Parkin S, Crooks PA. (Z)-2-(Cyclohexylidene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E Structure Reports Online. 62: o5576-o5577. DOI: 10.1107/S1600536806047453 |
0.305 |
|
| 2006 |
Sonar VN, Sean P, Crooks PA. 1-(Azepan-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806029837 |
0.307 |
|
| 2006 |
Sonar VN, Parkin S, Crooks PA. 1-(4-tert-Butylbenzyl)-1H-indole-3-carbaldehyde Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806026900 |
0.305 |
|
| 2006 |
Sonar VN, Parkin S, Crooks PA. Methyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806004892 |
0.316 |
|
| 2006 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-[1-(4-Methylphenylsulfonyl)-1H-indol-3-ylmethylene]-1-azabicyclo[2.2. 2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806001103 |
0.32 |
|
| 2006 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(4-Methoxybenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536805042637 |
0.301 |
|
| 2006 |
Sonar VN, Parkin S, Crooks PA. N-(2,5-Dichlorophenyl)-N′-[(E)-3-thienyl-methylene]hydrazine Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S160053680501634X |
0.324 |
|
| 2005 |
Wilkins LH, Miller DK, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes. The Aaps Journal. 7: E922-30. PMID 16594645 DOI: 10.1208/Aapsj070490 |
0.364 |
|
| 2005 |
Ayers JT, Xu R, Dwoskin LP, Crooks PA. A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine. The Aaps Journal. 7: E752-8. PMID 16353951 DOI: 10.1208/Aapsj070375 |
0.311 |
|
| 2005 |
Ayers JT, Clauset A, Schmitt JD, Dwoskin LP, Crooks PA. Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques. The Aaps Journal. 7: E678-85. PMID 16353944 DOI: 10.1208/Aapsj070368 |
0.324 |
|
| 2005 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Methoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 16272604 DOI: 10.1107/S0108270105030593 |
0.302 |
|
| 2005 |
Wei X, Sumithran SP, Deaciuc AG, Burton HR, Bush LP, Dwoskin LP, Crooks PA. Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors. Life Sciences. 78: 495-505. PMID 16197964 DOI: 10.1016/J.Lfs.2005.09.009 |
0.337 |
|
| 2005 |
Sumithran SP, Crooks PA, Xu R, Zhu J, Deaciuc AG, Wilkins LH, Dwoskin LP. Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity. The Aaps Journal. 7: E201-17. PMID 16146341 DOI: 10.1208/Aapsj070119 |
0.355 |
|
| 2005 |
Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands. Bioorganic & Medicinal Chemistry Letters. 15: 4463-6. PMID 16112864 DOI: 10.1016/J.Bmcl.2005.07.032 |
0.319 |
|
| 2005 |
Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. Journal of Medicinal Chemistry. 48: 5551-60. PMID 16107155 DOI: 10.1021/Jm0501228 |
0.396 |
|
| 2005 |
Sonar VN, Parkin S, Crooks PA. (E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2- nitrovinyl)-2-phenyl-1H-indole Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 16082109 DOI: 10.1107/S0108270105022298 |
0.322 |
|
| 2005 |
Sonar VN, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)-acrylonitrile and (Z)-3-[1-(4-tert- butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 15695916 DOI: 10.1107/S0108270104032925 |
0.331 |
|
| 2005 |
Sonar VN, Parkin S, Crooks PA. (2E,4E)-8-Methyl-2,4-bis(3-thienylmethylene)-8-azabicyclo[3.2.1]octan-3-one Acta Crystallographica Section E Structure Reports Online. 61: o3445-o3446. DOI: 10.1107/S160053680503028X |
0.327 |
|
| 2005 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Nitrobenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S1600536805028576 |
0.307 |
|
| 2005 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Thienyl)-3-(3,4,5-trimethoxyphenyl)-acrylonitrile Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S160053680500680X |
0.3 |
|
| 2004 |
Sonar VN, Parkin S, Crooks PA. 1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15295183 DOI: 10.1107/S0108270104013848 |
0.327 |
|
| 2004 |
Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. The Journal of Pharmacology and Experimental Therapeutics. 310: 1035-45. PMID 15121762 DOI: 10.1124/Jpet.104.068098 |
0.329 |
|
| 2004 |
Crooks PA, Ayers JT, Xu R, Sumithran SP, Grinevich VP, Wilkins LH, Deaciuc AG, Allen DD, Dwoskin LP. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 14: 1869-74. PMID 15050618 DOI: 10.1016/J.Bmcl.2003.10.074 |
0.306 |
|
| 2004 |
Dwoskin LP, Sumithran SP, Zhu J, Deaciuc AG, Ayers JT, Crooks PA. Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents. Bioorganic & Medicinal Chemistry Letters. 14: 1863-7. PMID 15050617 DOI: 10.1016/J.Bmcl.2003.10.073 |
0.347 |
|
| 2004 |
Sonar VN, Parkin S, Crooks PA. (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15004388 DOI: 10.1107/S0108270104002550 |
0.352 |
|
| 2004 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 14712032 DOI: 10.1107/S0108270103026076 |
0.34 |
|
| 2004 |
Sonar VN, Parkin S, Crooks PA. 2-(1-Methyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2] octan-3-one: Acid-catalyzed isomerization of the Z isomer to the E isomer Journal of Chemical Crystallography. 34: 239-244. DOI: 10.1023/B:Jocc.0000022421.28337.De |
0.301 |
|
| 2003 |
Bence AK, Crooks PA. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. Journal of Enzyme Inhibition and Medicinal Chemistry. 18: 383-94. PMID 14692504 DOI: 10.1080/1475636031000152277 |
0.734 |
|
| 2003 |
Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-hydroxy-4-methoxybenzyl-idene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 59. PMID 14605418 DOI: 10.1107/S0108270103022339 |
0.313 |
|
| 2003 |
Grinevich VP, Crooks PA, Sumithran SP, Haubner AJ, Ayers JT, Dwoskin LP. N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices. The Journal of Pharmacology and Experimental Therapeutics. 306: 1011-20. PMID 12766255 DOI: 10.1124/jpet.103.051789 |
0.786 |
|
| 2003 |
Bence AK, Adams VR, Crooks PA. L-Canavanine as a radiosensitization agent for human pancreatic cancer cells. Molecular and Cellular Biochemistry. 244: 37-43. PMID 12701807 DOI: 10.1023/A:1022435202066 |
0.739 |
|
| 2003 |
de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OA, Dwoskin LP, Crooks PA. Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers. Journal of Clinical Psychopharmacology. 23: 209-11. PMID 12640226 DOI: 10.1097/00004714-200304000-00018 |
0.745 |
|
| 2003 |
Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. The Journal of Pharmacology and Experimental Therapeutics. 304: 1268-74. PMID 12604705 DOI: 10.1124/Jpet.102.045856 |
0.308 |
|
| 2003 |
Bence AK, Worthen DR, Stables JP, Crooks PA. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacology, Biochemistry, and Behavior. 74: 771-5. PMID 12543244 DOI: 10.1016/S0091-3057(02)01079-1 |
0.737 |
|
| 2003 |
Wilkins LH, Grinevich VP, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 304: 400-10. PMID 12490617 DOI: 10.1124/Jpet.102.043349 |
0.346 |
|
| 2003 |
Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D. N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 13: 97-100. PMID 12467625 DOI: 10.1016/S0960-894X(02)00849-1 |
0.347 |
|
| 2003 |
Sonar VN, Parkin S, Crooks PA. 2-(1-Benzyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536803019809 |
0.334 |
|
| 2003 |
Zhu J, Crooks PA, Ayers JT, Sumithran SP, Dwoskin LP. N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit the Dopamine Transporter: Selectivity as Nicotinic Receptor Antagonists Drug Development Research. 60: 270-284. DOI: 10.1002/Ddr.10328 |
0.35 |
|
| 2002 |
Ring JR, Haubner AJ, Crooks PA. Novel antiepileptic and anticonvulsive therapeutic agents. Idrugs : the Investigational Drugs Journal. 5: 990-9. PMID 12800062 |
0.756 |
|
| 2002 |
Ayers JT, Dwoskin LP, Deaciuc AG, Grinevich VP, Zhu J, Crooks PA. bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. Bioorganic & Medicinal Chemistry Letters. 12: 3067-71. PMID 12372503 DOI: 10.1016/S0960-894X(02)00687-X |
0.341 |
|
| 2002 |
Wilkins LH, Haubner A, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices. The Journal of Pharmacology and Experimental Therapeutics. 301: 1088-96. PMID 12023541 DOI: 10.1124/Jpet.301.3.1088 |
0.786 |
|
| 2002 |
Bence AK, Worthen DR, Adams VR, Crooks PA. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anti-Cancer Drugs. 13: 313-20. PMID 11984075 DOI: 10.1097/00001813-200203000-00013 |
0.731 |
|
| 2002 |
Bence AK, Crooks PA. Synthesis of L-indospicine Synthetic Communications. 32: 2075-2082. DOI: 10.1081/Scc-120004860 |
0.727 |
|
| 2002 |
Xu R, Dwoskin LP, Grinevich V, Sumithran SP, Crooks PA. Synthesis and evaluation of conformationally restricted pyridino N-alkylated nicotine analogs as nicotinic acetylcholine receptor antagonists Drug Development Research. 55: 173-186. DOI: 10.1002/Ddr.10049 |
0.382 |
|
| 2001 |
Green TA, Crooks PA, Bardo MT, Dwoskin LP. Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices. Biochemical Pharmacology. 62: 1597-603. PMID 11755112 DOI: 10.1016/S0006-2952(01)00838-3 |
0.318 |
|
| 2001 |
Truong A, Xing X, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN. Pharmacological differences between immunoisolated native brain and heterologously expressed rat alpha4beta2 nicotinic receptors. Brain Research. Molecular Brain Research. 96: 68-76. PMID 11731010 DOI: 10.1016/S0169-328X(01)00268-6 |
0.311 |
|
| 2001 |
Xu R, Dwoskin LP, Grinevich VP, Deaciuc G, Crooks PA. Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues. Bioorganic & Medicinal Chemistry Letters. 11: 1245-8. PMID 11354387 DOI: 10.1016/S0960-894X(01)00193-7 |
0.325 |
|
| 2001 |
Ghosheh OA, Dwoskin LP, Miller DK, Crooks PA. Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 645-51. PMID 11302929 |
0.764 |
|
| 2001 |
Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, Crooks PA. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Research. 890: 343-6. PMID 11164802 DOI: 10.1016/S0006-8993(00)03201-7 |
0.751 |
|
| 2000 |
Byrd GD, Caldwell WS, Bhatti BS, Ravard A, Crooks PA. Determination of nicotine N-1-glucuronide, a quaternary N-glucuronide conjugate, in human biological samples. Drug Metabolism and Drug Interactions. 16: 281-97. PMID 11201307 DOI: 10.1515/Dmdi.2000.16.4.281 |
0.313 |
|
| 2000 |
Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. Bioorganic & Medicinal Chemistry Letters. 10: 2621-3. PMID 11128637 DOI: 10.1016/S0960-894X(00)00530-8 |
0.74 |
|
| 2000 |
Miller DK, Crooks PA, Dwoskin LP. Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes. Neuropharmacology. 39: 2654-62. PMID 11044735 DOI: 10.1016/S0028-3908(00)00140-4 |
0.315 |
|
| 2000 |
Ghosheh OA, Browne D, Rogers T, de Leon J, Dwoskin LP, Crooks PA. A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers. Journal of Pharmaceutical and Biomedical Analysis. 23: 543-9. PMID 10933548 DOI: 10.1016/S0731-7085(00)00339-3 |
0.767 |
|
| 2000 |
Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Dapsone analogs as potential polyamine binding site modulators of the N-methyl-D-aspartate receptor complex Drug Development Research. 51: 268-272. DOI: 10.1002/Ddr.8 |
0.754 |
|
| 1999 |
Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of Pharmaceutical and Biomedical Analysis. 19: 757-62. PMID 10698539 DOI: 10.1016/S0731-7085(98)00300-8 |
0.766 |
|
| 1999 |
Dwoskin LP, Wilkins LH, Pauly JR, Crooks PA. Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs. Annals of the New York Academy of Sciences. 868: 617-9. PMID 10414342 DOI: 10.1111/J.1749-6632.1999.Tb11334.X |
0.312 |
|
| 1998 |
Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Research. 18: 1527-32. PMID 9673365 |
0.774 |
|
| 1998 |
Crooks PA, Ravard A, Byrd GD. Synthesis of (E)-N-[methyl-d3]- 4-(3-pyridinyl)-3-buten-1-amine, a deuterated analogue of the nicotinic agonist RJR-2403 Journal of Labelled Compounds and Radiopharmaceuticals. 41: 1165-1171. DOI: 10.1002/(Sici)1099-1344(199812)41:12<1165::Aid-Jlcr162>3.0.Co;2-G |
0.303 |
|
| 1997 |
Phuket SRN, Trifonov LS, Crooks PA, Rosenthal GA, Freeman JW, Strodel WE. Synthesis and structure-activity studies of some antitumor congeners of L-canavanine Drug Development Research. 40: 325-332. DOI: 10.1002/(Sici)1098-2299(199704)40:4<325::Aid-Ddr6>3.0.Co;2-L |
0.319 |
|
| 1996 |
Deo NM, Crooks PA. Regioselective alkylation of N-(diphenylmethylidine)-3-(aminomethyl)pyridine: A simple route to minor tobacco alkaloids and related compounds Tetrahedron Letters. 37: 1137-1140. DOI: 10.1016/0040-4039(96)00002-0 |
0.339 |
|
| 1996 |
Ravard A, Crooks PA. Chiral purity determination of tobacco alkaloids and nicotine‐like compounds by 1H NMR spectroscopy in the presence of 1,1′‐binaphthyl‐2,2′‐diylphosphoric acid Chirality. 8: 295-299. DOI: 10.1002/(Sici)1520-636X(1996)8:4<295::Aid-Chir1>3.0.Co;2-F |
0.348 |
|
| 1995 |
Dwoskin LP, Teng L, Buxton ST, Ravard A, Deo N, Crooks PA. Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices. European Journal of Pharmacology. 276: 195-9. PMID 7781690 DOI: 10.1016/0014-2999(95)00077-X |
0.301 |
|
| 1995 |
Jona JA, Dittert LW, Crooks PA, Milosovich SM, Hussain AA. Design of novel prodrugs for the enhancement of the transdermal penetration of indomethacin International Journal of Pharmaceutics. 123: 127-136. DOI: 10.1016/0378-5173(95)00061-M |
0.305 |
|
| 1995 |
Chen J, Crooks PA, Hussain A. Kinetics and mechanism of hydrolysis of amidals: Their relative stability compared to structurally related acetals and acylals International Journal of Pharmaceutics. 123: 95-101. DOI: 10.1016/0378-5173(95)00044-J |
0.336 |
|
| 1995 |
Crooks PA, Ravard A, Wilkins LH, Teng LH, Buxton ST, Dwoskin LP. Inhibition of nicotine-evoked [3H]dopamine release by pyridino N-substituted nicotine analogues: A new class of nicotinic antagonist Drug Development Research. 36: 91-102. DOI: 10.1002/Ddr.430360204 |
0.354 |
|
| 1994 |
Byrd GD, Uhrig MS, deBethizy JD, Caldwell WS, Crooks PA, Ravard A, Riggs Rm. Direct determination of cotinine-N-glucuronide in urine using thermospray liquid chromatography/mass spectrometry. Biological Mass Spectrometry. 23: 103-7. PMID 8123688 DOI: 10.1002/Bms.1200230210 |
0.31 |
|
| 1994 |
Ravard A, Crooks PA. Synthesis of racemic [methyl‐d3]‐iabeled cis‐ and trans‐3′‐hydroxycotinine Journal of Labelled Compounds and Radiopharmaceuticals. 34: 1001-1009. DOI: 10.1002/Jlcr.2580341102 |
0.303 |
|
| 1992 |
Caldwell WS, Greene JM, Byrd GD, Chang KM, Uhrig MS, deBethizy JD, Crooks PA, Bhatti BS, Riggs RM. Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine. Chemical Research in Toxicology. 5: 280-5. PMID 1643259 DOI: 10.1021/Tx00026A021 |
0.308 |
|
| 1992 |
Dwoskin LP, Leibee LL, Jewell AL, Fang ZX, Crooks PA. Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites. Life Sciences. 50: PL233-7. PMID 1593921 DOI: 10.1016/0024-3205(92)90533-U |
0.359 |
|
| 1990 |
Crooks PA, Hassan SF, Benghiat E, Hemrick-Luecke SK, Fuller RW. 5'-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase. Drug Metabolism and Drug Interactions. 7: 111-41. PMID 2630176 DOI: 10.1515/Dmdi.1989.7.2-3.111 |
0.357 |
|
| 1989 |
Nwosu CG, Godin CS, Houdi AA, Damani LA, Crooks PA. Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs. The Journal of Pharmacy and Pharmacology. 40: 862-9. PMID 2907579 DOI: 10.1111/J.2042-7158.1988.Tb06289.X |
0.301 |
|
| 1989 |
Crooks PA, Deeks T, Desimone F. Synthesis of 5‐benzoyl‐5‐phenyl‐ and 5‐phenylhydroxymethyl‐5‐phenylhydantoins as potential anticonvulsants Journal of Heterocyclic Chemistry. 26: 1113-1117. DOI: 10.1002/Jhet.5570260439 |
0.309 |
|
| 1988 |
Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB. Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. Biochemical Pharmacology. 37: 1673-7. PMID 3377829 DOI: 10.1016/0006-2952(88)90426-1 |
0.312 |
|
| 1987 |
Cundy KC, Crooks PA. Biotransformation of primary nicotine metabolites II. Metabolism of [3h]-s-(-)-cotinine in the Guinea pig: Determination of in vivo urinary metabolites by high-performance liquid-radiochromatography Xenobiotica. 17: 785-792. PMID 3660848 DOI: 10.3109/00498258709043987 |
0.301 |
|
| 1986 |
Godin CS, Crooks PA, Damani LA. N-methylation of phenylpyridines and bispyridyls as a potential toxication route: Tissue distribution of azaheterocycle n-methyltransferase activity in the rabbit Toxicology Letters. 34: 217-222. PMID 3798480 DOI: 10.1016/0378-4274(86)90213-4 |
0.307 |
|
| 1986 |
Crooks PA, Burn P, Sewell RD, Upton N. Synthesis and antinociceptive properties of a series of exo- and endo-6-hydroxy-2-aminobenzonorbornenes. Journal of Pharmaceutical Sciences. 75: 1010-3. PMID 3795019 DOI: 10.1002/Jps.2600751022 |
0.329 |
|
| 1986 |
Damani LA, Shaker MS, Crooks PA, Godin CS, Nwosu C. N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 16: 645-50. PMID 3751119 DOI: 10.3109/00498258609043554 |
0.324 |
|
| 1986 |
Damani LA, Shaker MS, Godin CS, Crooks PA, Ansher SS, Jakoby WB. The ability of amine N-methyltransferases from rabbit liver to N-methylate azaheterocycles. The Journal of Pharmacy and Pharmacology. 38: 547-50. PMID 2875161 DOI: 10.1111/J.2042-7158.1986.Tb04636.X |
0.33 |
|
| 1985 |
Sommerville R, Rosenberg HE, Crooks PA. Synthesis and pharmacological evaluation of aromatic dihydroxylated spiro[indan‐1,3′‐pyrrolidine] and spiro[indan‐2,2′‐pyrrolidine] derivatives Journal of Pharmaceutical Sciences. 74: 553-555. PMID 4020632 DOI: 10.1002/Jps.2600740512 |
0.314 |
|
| 1984 |
Cundy KC, Crooks PA. High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine Journal of Chromatography B: Biomedical Sciences and Applications. 306: 291-301. PMID 6715467 DOI: 10.1016/S0378-4347(00)80891-9 |
0.304 |
|
| 1983 |
Damani LA, Crooks PA, Shaker MS, Caldwell J, D'Souza J, Smith RL. Species differences in the metabolic C- and N-oxidation , and N-methylation of [14C]pyridine in vivo. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 12: 527-34. PMID 7147998 DOI: 10.3109/00498258209038931 |
0.302 |
|
| 1983 |
Deeks T, Crooks PA, Waigh RD. Synthesis and analgesic properties of two leucine-enkephalin analogues containing a conformationally restrained N-terminal tyrosine residue Journal of Medicinal Chemistry. 26: 762-765. PMID 6842517 DOI: 10.1002/Chin.198338346 |
0.314 |
|
| 1983 |
Benghiat E, Crooks PA. Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: Inhibition of indole N-methyltransferase by (5′-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5′-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts Journal of Medicinal Chemistry. 26: 1470-1477. PMID 6620306 DOI: 10.1021/Jm00364A021 |
0.361 |
|
| 1982 |
Burn P, Crooks PA, Heatley F, Costall B, Naylor RJ, Nohria V. Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine. Journal of Medicinal Chemistry. 25: 363-8. PMID 7200145 DOI: 10.1002/Chin.198240136 |
0.345 |
|
| 1982 |
Crooks PA, Sommerville R. The synthesis and analgesic activities of some spiro[indan‐1,3′‐pyrrolidine] derivatives designed as rigid analogs of profadol Journal of Pharmaceutical Sciences. 71: 291-294. PMID 6461753 DOI: 10.1002/Jps.2600710306 |
0.3 |
|
| 1980 |
Crooks PA, Szyndler R. Synthesis and analgesic properties of some conformationally restricted analogues of profadol Journal of Medicinal Chemistry. 23: 679-682. PMID 6446605 DOI: 10.1021/Jm00180A021 |
0.342 |
|
| 1979 |
Crooks PA, Rosenberg HE. Synthesis of 5-hydroxy- and 5,6-dihydroxy-derivatives of spiro[indane-2,2′-pyrrolidine], rigid analogues of tyramine and dopamine respectively Journal of the Chemical Society, Perkin Transactions 1. 2719-2726. DOI: 10.1039/P19790002719 |
0.364 |
|
| 1978 |
Crooks PA, Rosenberg HE. Synthesis of spiro[tetralin-2,2′-pyrrolidine] and spiro[indan-2,2′-pyrrolidine] derivatives as potential analgesics Journal of Medicinal Chemistry. 21: 585-587. PMID 671457 DOI: 10.1021/Jm00204A016 |
0.343 |
|
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