| Year |
Citation |
Score |
| 2021 |
Saran C, Sundqvist L, Ho H, Niskanen J, Honkakoski P, Brouwer KL. Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors. The Journal of Pharmacology and Experimental Therapeutics. PMID 34794962 DOI: 10.1124/jpet.121.000828 |
0.331 |
|
| 2020 |
Ito K, Sjöstedt N, Malinen MM, Guo C, Brouwer KL. Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk. The Journal of Pharmacology and Experimental Therapeutics. PMID 32127372 DOI: 10.1124/Jpet.119.263459 |
0.472 |
|
| 2020 |
Brouwer K. S5.3 - Transporters in polycystic kidney disease Drug Metabolism and Pharmacokinetics. 35. DOI: 10.1016/J.Dmpk.2020.04.307 |
0.314 |
|
| 2019 |
Bezencon J, Beaudoin JJ, Ito K, Fu D, Roth SE, Brock WJ, Brouwer KL. Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31160314 DOI: 10.1124/Dmd.119.086785 |
0.519 |
|
| 2019 |
Brouwer K. Transporters and drug-induced liver injury Drug Metabolism and Pharmacokinetics. 34: S5. DOI: 10.1016/J.Dmpk.2018.09.026 |
0.421 |
|
| 2018 |
Ito K, Brouwer KL. LXR/FXR agonist alters transporter expression in sandwich-cultured human hepatocytes; proteomics-driven PBPK modeling implicates a drug–drug interaction with metformin Drug Metabolism and Pharmacokinetics. 33: S88. DOI: 10.1016/J.Dmpk.2017.11.287 |
0.413 |
|
| 2018 |
Brouwer KL. The role of hepatic transporters in drug disposition and elimination Drug Metabolism and Pharmacokinetics. 33: S2. DOI: 10.1016/J.Dmpk.2017.11.013 |
0.446 |
|
| 2017 |
Ali I, Welch MA, Lu Y, Swaan PW, Brouwer KL. Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28238947 DOI: 10.1016/J.Ejps.2017.02.011 |
0.426 |
|
| 2016 |
Woodhead JL, Brock WJ, Roth SE, Shoaf SE, Brouwer KL, Church R, Grammatopoulos TN, Stiles L, Siler SQ, Howell BA, Mosedale M, Watkins PB, Shoda LK. Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27655350 DOI: 10.1093/Toxsci/Kfw193 |
0.409 |
|
| 2016 |
Wells MA, Vendrov KC, Edin ML, Ferslew BC, Zha W, Nguyen BK, Church RJ, Lih FB, DeGraff LM, Brouwer KL, Barritt AS, Zeldin DC, Lee CR. Characterization of the Cytochrome P450 Epoxyeicosanoid Pathway in Non-alcoholic Steatohepatitis. Prostaglandins & Other Lipid Mediators. PMID 27401401 DOI: 10.1016/J.Prostaglandins.2016.07.002 |
0.338 |
|
| 2016 |
Lan K, Su M, Xie G, Ferslew BC, Brouwer KL, Rajani C, Liu C, Jia W. A key role for the 12-hydroxy group in the negative ion fragmentation of unconjugated C24 bile acids. Analytical Chemistry. PMID 27322813 DOI: 10.1021/Acs.Analchem.6B00573 |
0.308 |
|
| 2016 |
Guo C, Yang K, Brouwer KR, St Claire RL, Brouwer KL. Prediction of altered bile acid disposition due to inhibition of multiple transporters: An integrated approach using sandwich-cultured hepatocytes, mechanistic modeling and simulation. The Journal of Pharmacology and Experimental Therapeutics. PMID 27233294 DOI: 10.1124/Jpet.116.231928 |
0.41 |
|
| 2016 |
Lu Y, Slizgi JR, Brouwer KR, Claire RL, Freeman KM, Pan M, Brock WJ, Brouwer KL. Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27013400 DOI: 10.1124/Dmd.115.067629 |
0.484 |
|
| 2016 |
Yang K, Guo C, Woodhead JL, St Claire RL, Watkins PB, Siler SQ, Howell BA, Brouwer KL. Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury. Journal of Pharmaceutical Sciences. 105: 443-59. PMID 26869411 DOI: 10.1016/J.Xphs.2015.11.008 |
0.459 |
|
| 2015 |
Slizgi JR, Lu Y, Brouwer KR, St Claire RL, Freeman KM, Pan M, Brock WJ, Brouwer KL. Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury? Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26507107 DOI: 10.1093/Toxsci/Kfv231 |
0.47 |
|
| 2015 |
Ferslew BC, Xie G, Johnston CK, Su M, Stewart PW, Jia W, Brouwer KL, Sidney Barritt A. Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis. Digestive Diseases and Sciences. PMID 26138654 DOI: 10.1007/S10620-015-3776-8 |
0.342 |
|
| 2015 |
Brouwer KL, Aleksunes LM, Brandys B, Giacoia GP, Knipp G, Lukacova V, Meibohm B, Nigam SK, Rieder M, de Wildt SN. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical Pharmacology and Therapeutics. 98: 266-87. PMID 26088472 DOI: 10.1002/Cpt.176 |
0.404 |
|
| 2015 |
Welch MA, Köck K, Urban TJ, Brouwer KL, Swaan PW. Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 725-34. PMID 25735837 DOI: 10.1124/Dmd.114.062539 |
0.367 |
|
| 2015 |
Yang K, Pfeifer ND, Köck K, Brouwer KL. Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury. The Journal of Pharmacology and Experimental Therapeutics. 353: 415-23. PMID 25711339 DOI: 10.1124/Jpet.114.221564 |
0.524 |
|
| 2015 |
Ferslew BC, Johnston CK, Tsakalozou E, Bridges AS, Paine MF, Jia W, Stewart PW, Barritt AS, Brouwer KL. Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis. Clinical Pharmacology and Therapeutics. 97: 419-27. PMID 25669174 DOI: 10.1002/Cpt.66 |
0.423 |
|
| 2014 |
Woodhead JL, Yang K, Siler SQ, Watkins PB, Brouwer KL, Barton HA, Howell BA. Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury. Frontiers in Pharmacology. 5: 240. PMID 25426072 DOI: 10.3389/Fphar.2014.00240 |
0.477 |
|
| 2014 |
Powell J, Farasyn T, Köck K, Meng X, Pahwa S, Brouwer KL, Yue W. Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1964-70. PMID 25200870 DOI: 10.1124/Dmd.114.056945 |
0.428 |
|
| 2014 |
Ferslew BC, Köck K, Bridges AS, Brouwer KL. Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1567-74. PMID 24958844 DOI: 10.1124/Dmd.114.057554 |
0.496 |
|
| 2014 |
Yang K, Brouwer KL. Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1219-26. PMID 24799397 DOI: 10.1124/Dmd.114.057190 |
0.533 |
|
| 2014 |
Ferslew BC, Brouwer KL. Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates. Toxicological Sciences : An Official Journal of the Society of Toxicology. 139: 99-107. PMID 24563379 DOI: 10.1093/Toxsci/Kfu033 |
0.523 |
|
| 2014 |
Yang K, Pfeifer ND, Hardwick RN, Yue W, Stewart PW, Brouwer KL. An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown. Molecular Pharmaceutics. 11: 766-75. PMID 24410402 DOI: 10.1021/Mp400471E |
0.502 |
|
| 2014 |
Pfeifer ND, Hardwick RN, Brouwer KL. Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics. Annual Review of Pharmacology and Toxicology. 54: 509-35. PMID 24160696 DOI: 10.1146/Annurev-Pharmtox-011613-140021 |
0.494 |
|
| 2014 |
Köck K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, Brouwer KL. Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 665-74. PMID 24154606 DOI: 10.1124/Dmd.113.054304 |
0.425 |
|
| 2014 |
Joy MS, Frye RF, Nolin TD, Roberts BV, La MK, Wang J, Brouwer KL, Dooley MA, Falk RJ. In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases. Pharmacotherapy. 34: 114-22. PMID 24038489 DOI: 10.1002/Phar.1347 |
0.354 |
|
| 2013 |
Pfeifer ND, Bridges AS, Ferslew BC, Hardwick RN, Brouwer KL. Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver. The Journal of Pharmacology and Experimental Therapeutics. 347: 737-45. PMID 24080682 DOI: 10.1124/Jpet.113.208314 |
0.515 |
|
| 2013 |
Pfeifer ND, Yang K, Brouwer KL. Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 347: 727-36. PMID 24023367 DOI: 10.1124/Jpet.113.207472 |
0.513 |
|
| 2013 |
Pfeifer ND, Harris KB, Yan GZ, Brouwer KL. Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1949-56. PMID 23990525 DOI: 10.1124/Dmd.113.052134 |
0.44 |
|
| 2013 |
Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR. Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Molecular Pharmacology. 84: 182-9. PMID 23680637 DOI: 10.1124/Mol.112.084517 |
0.398 |
|
| 2013 |
Yang K, Köck K, Sedykh A, Tropsha A, Brouwer KL. An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters. Journal of Pharmaceutical Sciences. 102: 3037-57. PMID 23653385 DOI: 10.1002/Jps.23584 |
0.412 |
|
| 2013 |
Chu X, Korzekwa K, Elsby R, Fenner K, Galetin A, Lai Y, Matsson P, Moss A, Nagar S, Rosania GR, Bai JP, Polli JW, Sugiyama Y, Brouwer KL. Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver. Clinical Pharmacology and Therapeutics. 94: 126-41. PMID 23588320 DOI: 10.1038/Clpt.2013.78 |
0.451 |
|
| 2013 |
Brouwer KL, Keppler D, Hoffmaster KA, Bow DA, Cheng Y, Lai Y, Palm JE, Stieger B, Evers R. In vitro methods to support transporter evaluation in drug discovery and development. Clinical Pharmacology and Therapeutics. 94: 95-112. PMID 23588315 DOI: 10.1038/Clpt.2013.81 |
0.757 |
|
| 2013 |
Swift B, Nebot N, Lee JK, Han T, Proctor WR, Thakker DR, Lang D, Radtke M, Gnoth MJ, Brouwer KL. Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1179-86. PMID 23482500 DOI: 10.1124/Dmd.112.048181 |
0.451 |
|
| 2013 |
Köck K, Xie Y, Hawke RL, Oberlies NH, Brouwer KL. Interaction of silymarin flavonolignans with organic anion-transporting polypeptides. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 958-65. PMID 23401473 DOI: 10.1124/Dmd.112.048272 |
0.477 |
|
| 2013 |
Griffin LM, Watkins PB, Perry CH, St Claire RL, Brouwer KL. Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 188-96. PMID 23091188 DOI: 10.1124/Dmd.112.047225 |
0.437 |
|
| 2012 |
Köck K, Brouwer KL. A perspective on efflux transport proteins in the liver. Clinical Pharmacology and Therapeutics. 92: 599-612. PMID 22948894 DOI: 10.1038/Clpt.2012.79 |
0.477 |
|
| 2012 |
Marion TL, Perry CH, St Claire RL, Brouwer KL. Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes. Toxicology and Applied Pharmacology. 261: 1-9. PMID 22342602 DOI: 10.1016/J.Taap.2012.02.002 |
0.81 |
|
| 2012 |
Yan GZ, Generaux CN, Yoon M, Goldsmith RB, Tidwell RR, Hall JE, Olson CA, Clewell HJ, Brouwer KL, Paine MF. A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 6-17. PMID 21953913 DOI: 10.1124/Dmd.111.040063 |
0.435 |
|
| 2011 |
Griffin L, Annaert P, Brouwer KL. Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors. Journal of Pharmaceutical Sciences. 100: 3636-54. PMID 21698598 DOI: 10.1002/Jps.22655 |
0.388 |
|
| 2011 |
Yan GZ, Brouwer KL, Pollack GM, Wang MZ, Tidwell RR, Hall JE, Paine MF. Mechanisms underlying differences in systemic exposure of structurally similar active metabolites: comparison of two preclinical hepatic models. The Journal of Pharmacology and Experimental Therapeutics. 337: 503-12. PMID 21320872 DOI: 10.1124/Jpet.110.177220 |
0.652 |
|
| 2011 |
Marion TL, Perry CH, St Claire RL, Yue W, Brouwer KL. Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 371-80. PMID 21262925 DOI: 10.1093/Toxsci/Kfr014 |
0.816 |
|
| 2011 |
Yue W, Lee JK, Abe K, Sugiyama Y, Brouwer KL. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 441-7. PMID 21106720 DOI: 10.1124/Dmd.110.035188 |
0.491 |
|
| 2010 |
Swift B, Yue W, Brouwer KL. Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes. Pharmaceutical Research. 27: 1987-98. PMID 20652625 DOI: 10.1007/S11095-010-0203-X |
0.517 |
|
| 2010 |
Yanni SB, Augustijns PF, Benjamin DK, Brouwer KL, Thakker DR, Annaert PP. In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1848-56. PMID 20606004 DOI: 10.1124/Dmd.110.033811 |
0.535 |
|
| 2010 |
Lee JK, Paine MF, Brouwer KL. Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 334: 410-8. PMID 20430841 DOI: 10.1124/Jpet.110.165852 |
0.533 |
|
| 2010 |
Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, et al. Membrane transporters in drug development. Nature Reviews. Drug Discovery. 9: 215-36. PMID 20190787 DOI: 10.1038/Nrd3028 |
0.796 |
|
| 2010 |
Swift B, Pfeifer ND, Brouwer KL. Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metabolism Reviews. 42: 446-71. PMID 20109035 DOI: 10.3109/03602530903491881 |
0.442 |
|
| 2010 |
Swift B, Brouwer KL. Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes. Molecular Pharmaceutics. 7: 491-500. PMID 19968322 DOI: 10.1021/Mp900227A |
0.356 |
|
| 2010 |
Lee JK, Marion TL, Abe K, Lim C, Pollock GM, Brouwer KL. Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation. The Journal of Pharmacology and Experimental Therapeutics. 332: 26-34. PMID 19801447 DOI: 10.1124/Jpet.109.156653 |
0.824 |
|
| 2010 |
Wolf KK, Vora S, Webster LO, Generaux GT, Polli JW, Brouwer KL. Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 297-309. PMID 19706322 DOI: 10.1016/J.Tiv.2009.08.009 |
0.529 |
|
| 2009 |
Swift B, Tian X, Brouwer KL. Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function. Pharmaceutical Research. 26: 1942-51. PMID 19495943 DOI: 10.1007/S11095-009-9909-Z |
0.373 |
|
| 2009 |
Lee JK, Abe K, Bridges AS, Patel NJ, Raub TJ, Pollack GM, Brouwer KL. Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1916-21. PMID 19487254 DOI: 10.1124/Dmd.109.026815 |
0.621 |
|
| 2009 |
Yue W, Abe K, Brouwer KL. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Molecular Pharmaceutics. 6: 134-43. PMID 19105722 DOI: 10.1021/Mp800100E |
0.47 |
|
| 2009 |
Abe K, Bridges AS, Brouwer KL. Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 447-52. PMID 19074974 DOI: 10.1124/Dmd.108.023465 |
0.401 |
|
| 2009 |
Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, Brouwer KL. Relationship between drug/metabolite exposure and impairment of excretory transport function. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 386-90. PMID 19022942 DOI: 10.1124/Dmd.108.023648 |
0.764 |
|
| 2008 |
Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Brouwer KL. Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2156-8. PMID 18719241 DOI: 10.1124/Dmd.108.022053 |
0.829 |
|
| 2008 |
Miranda SR, Lee JK, Brouwer KL, Wen Z, Smith PC, Hawke RL. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2219-26. PMID 18687803 DOI: 10.1124/Dmd.108.021790 |
0.498 |
|
| 2008 |
Wolf KK, Brouwer KR, Pollack GM, Brouwer KL. Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2086-92. PMID 18653747 DOI: 10.1124/Dmd.108.020842 |
0.635 |
|
| 2008 |
Abe K, Bridges AS, Yue W, Brouwer KL. In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance. The Journal of Pharmacology and Experimental Therapeutics. 326: 983-90. PMID 18574002 DOI: 10.1124/Jpet.108.138073 |
0.516 |
|
| 2008 |
Ghibellini G, Leslie EM, Pollack GM, Brouwer KL. Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies. Pharmaceutical Research. 25: 1851-60. PMID 18509604 DOI: 10.1007/S11095-008-9597-0 |
0.801 |
|
| 2008 |
Tian X, Swift B, Zamek-Gliszczynski MJ, Belinsky MG, Kruh GD, Brouwer KL. Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 911-5. PMID 18276836 DOI: 10.1124/Dmd.107.019273 |
0.711 |
|
| 2008 |
Lee JK, Leslie EM, Zamek-Gliszczynski MJ, Brouwer KL. Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity. Toxicology and Applied Pharmacology. 228: 17-23. PMID 18191164 DOI: 10.1016/J.Taap.2007.11.020 |
0.741 |
|
| 2008 |
Bow DA, Perry JL, Miller DS, Pritchard JB, Brouwer KL. Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 198-202. PMID 17954525 DOI: 10.1124/Dmd.107.018200 |
0.485 |
|
| 2008 |
Tian X, Zamek-Gliszczynski MJ, Li J, Bridges AS, Nezasa K, Patel NJ, Raub TJ, Brouwer KL. Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 61-4. PMID 17913796 DOI: 10.1124/Dmd.107.017319 |
0.738 |
|
| 2007 |
Marion TL, Leslie EM, Brouwer KL. Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. Molecular Pharmaceutics. 4: 911-8. PMID 17963355 DOI: 10.1021/Mp0700357 |
0.832 |
|
| 2007 |
Leslie EM, Ghibellini G, Nezasa K, Brouwer KL. Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats. Carcinogenesis. 28: 2650-6. PMID 17724374 DOI: 10.1093/Carcin/Bgm187 |
0.813 |
|
| 2007 |
Tian X, Li J, Zamek-Gliszczynski MJ, Bridges AS, Zhang P, Patel NJ, Raub TJ, Pollack GM, Brouwer KL. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice. Antimicrobial Agents and Chemotherapy. 51: 3230-4. PMID 17576841 DOI: 10.1128/Aac.00082-07 |
0.764 |
|
| 2007 |
Leslie EM, Watkins PB, Kim RB, Brouwer KL. Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 321: 1170-8. PMID 17374746 DOI: 10.1124/Jpet.106.119073 |
0.427 |
|
| 2007 |
Luo G, Garner CE, Xiong H, Hu H, Richards LE, Brouwer KL, Duan J, Decicco CP, Maduskuie T, Shen H, Lee FW, Gan LS. Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 835-40. PMID 17332143 DOI: 10.1124/Dmd.106.013946 |
0.442 |
|
| 2007 |
Ghibellini G, Vasist LS, Leslie EM, Heizer WD, Kowalsky RJ, Calvo BF, Brouwer KL. In vitro-in vivo correlation of hepatobiliary drug clearance in humans. Clinical Pharmacology and Therapeutics. 81: 406-13. PMID 17235333 DOI: 10.1038/Sj.Clpt.6100059 |
0.791 |
|
| 2007 |
Ghibellini G, Bridges AS, Generaux CN, Brouwer KL. In vitro and in vivo determination of piperacillin metabolism in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 345-9. PMID 17194717 DOI: 10.1124/Dmd.106.012278 |
0.799 |
|
| 2006 |
Zamek-Gliszczynski MJ, Nezasa K, Tian X, Bridges AS, Lee K, Belinsky MG, Kruh GD, Brouwer KL. Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 1485-91. PMID 16988054 DOI: 10.1124/Jpet.106.110106 |
0.734 |
|
| 2006 |
Zamek-Gliszczynski MJ, Nezasa K, Tian X, Kalvass JC, Patel NJ, Raub TJ, Brouwer KL. The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice. Molecular Pharmacology. 70: 2127-33. PMID 16959944 DOI: 10.1124/Mol.106.026955 |
0.735 |
|
| 2006 |
Ghibellini G, Vasist LS, Hill TE, Heizer WD, Kowalsky RJ, Brouwer KL. Determination of the biliary excretion of piperacillin in humans using a novel method. British Journal of Clinical Pharmacology. 62: 304-8. PMID 16934046 DOI: 10.1111/J.1365-2125.2006.02662.X |
0.757 |
|
| 2006 |
Zamek-Gliszczynski MJ, Hoffmaster KA, Humphreys JE, Tian X, Nezasa K, Brouwer KL. Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat. The Journal of Pharmacology and Experimental Therapeutics. 319: 459-67. PMID 16857726 DOI: 10.1124/Jpet.106.101840 |
0.842 |
|
| 2006 |
Ghibellini G, Leslie EM, Brouwer KL. Methods to evaluate biliary excretion of drugs in humans: an updated review. Molecular Pharmaceutics. 3: 198-211. PMID 16749853 DOI: 10.1021/Mp060011K |
0.789 |
|
| 2006 |
McRae MP, Lowe CM, Tian X, Bourdet DL, Ho RH, Leake BF, Kim RB, Brouwer KL, Kashuba AD. Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 318: 1068-75. PMID 16720753 DOI: 10.1124/Jpet.106.102657 |
0.518 |
|
| 2006 |
Turncliff RZ, Hoffmaster KA, Kalvass JC, Pollack GM, Brouwer KL. Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 318: 881-9. PMID 16690724 DOI: 10.1124/Jpet.106.102616 |
0.807 |
|
| 2006 |
Turncliff RZ, Tian X, Brouwer KL. Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes. Biochemical Pharmacology. 71: 1520-9. PMID 16542640 DOI: 10.1016/J.Bcp.2006.02.004 |
0.768 |
|
| 2006 |
Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 27: 447-86. PMID 16472997 DOI: 10.1016/J.Ejps.2005.12.007 |
0.811 |
|
| 2006 |
Nezasa K, Tian X, Zamek-Gliszczynski MJ, Patel NJ, Raub TJ, Brouwer KL. Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 718-23. PMID 16434545 DOI: 10.1124/Dmd.105.007922 |
0.672 |
|
| 2006 |
Johnson BM, Zhang P, Schuetz JD, Brouwer KL. Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 556-62. PMID 16204465 DOI: 10.1124/Dmd.105.005793 |
0.504 |
|
| 2006 |
GHIBELLINI G, VASIST L, HEIZER W, KOWALSKY R, BROUWER K. PI-48Quantitation of Tc-99M sestamibi biliary excretion in humans Clinical Pharmacology & Therapeutics. 79: P19-P19. DOI: 10.1016/J.Clpt.2005.12.069 |
0.755 |
|
| 2005 |
Tian X, Zhang P, Zamek-Gliszczynski MJ, Brouwer KL. Knocking down transport: applications of RNA interference in the study of drug transport proteins. Drug Metabolism Reviews. 37: 705-23. PMID 16393889 DOI: 10.1080/03602530500364098 |
0.632 |
|
| 2005 |
Chandra P, Johnson BM, Zhang P, Pollack GM, Brouwer KL. Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1238-43. PMID 15908472 DOI: 10.1124/Dmd.105.003665 |
0.778 |
|
| 2005 |
Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, Zhao R, Polli JW, Humphreys JE, Webster LO, Bridges AS, Kalvass JC, Brouwer KL. Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1158-65. PMID 15860656 DOI: 10.1124/Dmd.104.002188 |
0.836 |
|
| 2005 |
Zhang P, Tian X, Chandra P, Brouwer KL. Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes. Molecular Pharmacology. 67: 1334-41. PMID 15662046 DOI: 10.1124/Mol.104.004481 |
0.631 |
|
| 2005 |
Chandra P, Zhang P, Brouwer KL. Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G1252-8. PMID 15650133 DOI: 10.1152/Ajpgi.00362.2004 |
0.695 |
|
| 2005 |
Annaert PP, Brouwer KL. Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 388-94. PMID 15608134 DOI: 10.1124/Dmd.104.001669 |
0.517 |
|
| 2005 |
Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 287-93. PMID 15528320 DOI: 10.1124/Dmd.104.001420 |
0.831 |
|
| 2005 |
Kemp DC, Zamek-Gliszczynski MJ, Brouwer KL. Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 207-14. PMID 15509663 DOI: 10.1093/Toxsci/Kfi020 |
0.747 |
|
| 2004 |
Ghibellini G, Johnson BM, Kowalsky RJ, Heizer WD, Brouwer KL. A novel method for the determination of biliary clearance in humans. The Aaps Journal. 6: e33. PMID 15760098 DOI: 10.1208/Aapsj060433 |
0.785 |
|
| 2004 |
Kemp DC, Brouwer KL. Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure. Toxicology in Vitro : An International Journal Published in Association With Bibra. 18: 869-77. PMID 15465654 DOI: 10.1016/J.Tiv.2004.04.014 |
0.48 |
|
| 2004 |
Tian X, Zamek-Gliszczynski MJ, Zhang P, Brouwer KL. Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes. Molecular Pharmacology. 66: 1004-10. PMID 15385645 DOI: 10.1124/mol.66.4. |
0.706 |
|
| 2004 |
Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM, Brouwer KL. Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems. The Journal of Pharmacology and Experimental Therapeutics. 311: 1203-10. PMID 15302892 DOI: 10.1124/Jpet.104.070201 |
0.826 |
|
| 2004 |
Hoffmaster KA, Turncliff RZ, LeCluyse EL, Kim RB, Meier PJ, Brouwer KL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharmaceutical Research. 21: 1294-302. PMID 15290872 DOI: 10.1023/B:Pham.0000033018.97745.0D |
0.809 |
|
| 2004 |
Turncliff RZ, Meier PJ, Brouwer KL. Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 834-9. PMID 15258109 DOI: 10.1124/Dmd.32.8.834 |
0.805 |
|
| 2004 |
Chandra P, Brouwer KL. The complexities of hepatic drug transport: current knowledge and emerging concepts. Pharmaceutical Research. 21: 719-35. PMID 15180326 DOI: 10.1023/B:Pham.0000026420.79421.8F |
0.663 |
|
| 2004 |
Persky AM, Berry NS, Pollack GM, Brouwer KL. Modelling the cardiovascular effects of ephedrine. British Journal of Clinical Pharmacology. 57: 552-62. PMID 15089807 DOI: 10.1111/J.1365-2125.2003.02062.X |
0.545 |
|
| 2003 |
Patel NJ, Zamek-Gliszczynski MJ, Zhang P, Han YH, Jansen PL, Meier PJ, Stieger B, Brouwer KL. Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions. Molecular Pharmacology. 64: 154-9. PMID 12815171 DOI: 10.1124/Mol.64.1.154 |
0.734 |
|
| 2003 |
McRae MP, Brouwer KL, Kashuba AD. Cytokine regulation of P-glycoprotein. Drug Metabolism Reviews. 35: 19-33. PMID 12635814 DOI: 10.1081/Dmr-120018247 |
0.362 |
|
| 2003 |
Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, Brouwer KL. Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver. The Journal of Pharmacology and Experimental Therapeutics. 304: 801-9. PMID 12538836 DOI: 10.1124/Jpet.102.044107 |
0.838 |
|
| 2002 |
Brouwer KL, Pollack GM. Pharmacogenetics: is the right drug for the right patient sufficient? Advanced Drug Delivery Reviews. 54: 1243-4. PMID 12406642 DOI: 10.1016/S0169-409X(02)00164-3 |
0.542 |
|
| 2002 |
Lee K, Ng C, Brouwer KL, Thakker DR. Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers. The Journal of Pharmacology and Experimental Therapeutics. 303: 574-80. PMID 12388638 DOI: 10.1124/Jpet.102.038521 |
0.398 |
|
| 2002 |
Xiong H, Suzuki H, Sugiyama Y, Meier PJ, Pollack GM, Brouwer KL. Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 962-9. PMID 12167560 DOI: 10.1124/Dmd.30.9.962 |
0.657 |
|
| 2002 |
Xiong H, Yoshinari K, Brouwer KL, Negishi M. Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 918-23. PMID 12124310 DOI: 10.1124/Dmd.30.8.918 |
0.406 |
|
| 2002 |
Murthy BR, Pollack GM, Brouwer KL. Contribution of morphine-6-glucuronide to antinociception following intravenous administration of morphine to healthy volunteers. Journal of Clinical Pharmacology. 42: 569-76. PMID 12017351 DOI: 10.1177/00912700222011508 |
0.55 |
|
| 2002 |
Chandra P, Lecluyse EL, Brouwer KL. Optimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes. In Vitro Cellular & Developmental Biology. Animal. 37: 380-5. PMID 11515972 DOI: 10.1007/Bf02577575 |
0.619 |
|
| 1999 |
Liu X, LeCluyse EL, Brouwer KR, Gan LS, Lemasters JJ, Stieger B, Meier PJ, Brouwer KL. Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. The American Journal of Physiology. 277: G12-21. PMID 10409146 DOI: 10.1152/Ajpgi.1999.277.1.G12 |
0.36 |
|
| 1999 |
Pithavala YK, Heizer WD, Parr AF, O'Connor-Semmes RL, Brouwer KL. Use of the InteliSite capsule to study ranitidine absorption from various sites within the human intestinal tract. Pharmaceutical Research. 15: 1869-75. PMID 9892471 DOI: 10.1023/A:1011910223812 |
0.327 |
|
| 1998 |
Liu X, Brouwer KL, Gan LS, Brouwer KR, Stieger B, Meier PJ, Audus KL, LeCluyse EL. Partial maintenance of taurocholate uptake by adult rat hepatocytes cultured in a collagen sandwich configuration. Pharmaceutical Research. 15: 1533-9. PMID 9794494 DOI: 10.1023/A:1011994831139 |
0.395 |
|
| 1998 |
Socinski MA, Mudd PN, Radomski KM, Steagall A, Lawrence P, Bernard S, Letrent SP, Gonzalez P, Brouwer KL. Phase I trial of a 96 h paclitaxel infusion with filgrastim support in refractory solid tumor patients. Anti-Cancer Drugs. 9: 611-9. PMID 9773805 DOI: 10.1097/00001813-199808000-00006 |
0.321 |
|
| 1998 |
Reynolds KS, Song MH, Heizer WD, Burns CB, Sica DA, Brouwer KL. Effect of pancreatico-biliary secretions and GI transit time on the absorption and pharmacokinetic profile of ranitidine in humans. Pharmaceutical Research. 15: 1281-5. PMID 9706062 DOI: 10.1023/A:1011908412058 |
0.323 |
|
| 1997 |
Noone PG, Regnis JA, Liu X, Brouwer KL, Robinson M, Edwards L, Knowles MR. Airway deposition and clearance and systemic pharmacokinetics of amiloride following aerosolization with an ultrasonic nebulizer to normal airways. Chest. 112: 1283-90. PMID 9367469 DOI: 10.1378/Chest.112.5.1283 |
0.355 |
|
| 1997 |
Nolting A, DeLong RK, Fisher MH, Wickstrom E, Pollack GM, Juliano RL, Brouwer KL. Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver. Pharmaceutical Research. 14: 516-21. PMID 9144742 DOI: 10.1023/A:1012116003706 |
0.663 |
|
| 1996 |
Brouwer KL, Thurman RG. Isolated perfused liver Pharmaceutical Biotechnology. 8: 161-192. PMID 8791810 DOI: 10.1007/978-1-4899-1863-5_10 |
0.438 |
|
| 1996 |
Matheny CJ, Taft DR, Brouwer KL, Pollack GM. Evidence for reversible sequestration of morphine in rat liver. Biochemical Pharmacology. 52: 535-41. PMID 8759025 DOI: 10.1016/0006-2952(96)00304-8 |
0.749 |
|
| 1996 |
Moore KH, Raasch RH, Brouwer KL, Opheim K, Cheeseman SH, Eyster E, Lemon SM, van der Horst CM. Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062). Antimicrobial Agents and Chemotherapy. 39: 2732-7. PMID 8593010 DOI: 10.1128/Aac.39.12.2732 |
0.343 |
|
| 1996 |
Suttle AB, Brouwer KL. Gastrointestinal transit and distribution of ranitidine in the rat. Pharmaceutical Research. 12: 1316-22. PMID 8570528 DOI: 10.1023/A:1016221606898 |
0.355 |
|
| 1996 |
Suttle AB, Brouwer KL. Regional gastrointestinal absorption of ranitidine in the rat. Pharmaceutical Research. 12: 1311-5. PMID 8570527 DOI: 10.1023/A:1016269522828 |
0.344 |
|
| 1993 |
Studenberg SD, Brouwer KL. Effect of phenobarbital and p-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: use of a kinetic model to examine the rates of formation and egress. Journal of Pharmacokinetics and Biopharmaceutics. 21: 175-94. PMID 8229679 DOI: 10.1007/Bf01059769 |
0.401 |
|
| 1990 |
Hussey EK, Dukes GE, Messenheimer JA, Brouwer KL, Donn KH, Krol TF, Hak LJ. Evaluation of the pharmacokinetic interaction between diazepam and ACC-9653 (a phenytoin prodrug) in healthy male volunteers. Pharmaceutical Research. 7: 1172-6. PMID 2293218 DOI: 10.1023/A:1015940527815 |
0.338 |
|
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