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Christopher T. Walsh, Ph.D. - Publications

Affiliations: 
1972-1987 Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
 1987- Harvard Medical School Harvard University, Cambridge, MA, United States 
Area:
Enzymes
Website:
https://chemistry.harvard.edu/news/christopher-t-walsh-1944-2023
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Year Citation  Score
2021 Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C. Prospects for Antibacterial Discovery and Development. Journal of the American Chemical Society. 143: 21127-21142. PMID 34860516 DOI: 10.1021/jacs.1c10200  0.647
2019 Walsh CT. Biologically generated carbon dioxide: nature's versatile chemical strategies for carboxy lyases. Natural Product Reports. PMID 31074473 DOI: 10.1039/C9Np00015A  0.332
2018 Walsh CT, Moore BS. Enzymatic Cascade Reactions in Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 30156048 DOI: 10.1002/Anie.201807844  0.373
2018 Walsh CT. Nature Builds Macrocycles and Heterocycle into its Antimicrobial Frameworks: Decipering Biosynthetic Strategy. Acs Infectious Diseases. PMID 29993235 DOI: 10.1021/Acsinfecdis.8B00101  0.39
2018 Walsh CT, Tu BP, Tang Y. Correction to: Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism. Chemical Reviews. PMID 29620360 DOI: 10.1021/Acs.Chemrev.8B00181  0.384
2017 Walsh CT, Tu BP, Tang Y. Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism. Chemical Reviews. PMID 29272116 DOI: 10.1021/Acs.Chemrev.7B00510  0.426
2017 Walsh CT, Tang Y. Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions. Biochemistry. PMID 29236467 DOI: 10.1021/Acs.Biochem.7B01161  0.568
2017 Walsh CT. Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds? Natural Product Reports. PMID 28513710 DOI: 10.1039/C7Np00011A  0.361
2017 Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA. SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product. Journal of the American Chemical Society. PMID 28170244 DOI: 10.1021/Jacs.6B10792  0.811
2016 Tang MC, Zou Y, Watanabe K, Walsh CT, Tang Y. Oxidative Cyclization in Natural Product Biosynthesis. Chemical Reviews. PMID 27936626 DOI: 10.1021/Acs.Chemrev.6B00478  0.453
2016 Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL. Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791103 DOI: 10.1073/Pnas.1608615113  0.396
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Walsh CT, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.764
2015 Walsh CT. Insights into the chemical logic and enzymatic machinery of NRPS assembly lines. Natural Product Reports. PMID 26175103 DOI: 10.1039/C5Np00035A  0.341
2015 Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S. Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution. Bmc Structural Biology. 15: 13. PMID 26170207 DOI: 10.1186/S12900-015-0040-6  0.592
2015 Rojas Murcia N, Lee X, Waridel P, Maspoli A, Imker HJ, Chai T, Walsh CT, Reimmann C. The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor. Frontiers in Microbiology. 6: 170. PMID 25814981 DOI: 10.3389/Fmicb.2015.00170  0.322
2015 Li B, Wever WJ, Walsh CT, Bowers AA. Correction: Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Natural Product Reports. 32: 348-9. PMID 25598489 DOI: 10.1039/C4Np90047B  0.798
2015 Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S. Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: A case of challenging structure determination at low resolution Bmc Structural Biology. 15. DOI: 10.1186/s12900-015-0040-6  0.474
2015 Walsh CT. Nature loves nitrogen heterocycles Tetrahedron Letters. 56: 3075-3081. DOI: 10.1016/J.Tetlet.2014.11.046  0.313
2014 Walsh CT. Biological matching of chemical reactivity: pairing indole nucleophilicity with electrophilic isoprenoids. Acs Chemical Biology. 9: 2718-28. PMID 25303280 DOI: 10.1021/Cb500695K  0.32
2014 Setser JW, Heemstra JR, Walsh CT, Drennan CL. Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase. Biochemistry. 53: 6063-77. PMID 25184411 DOI: 10.1021/Bi500655Q  0.412
2014 Nakayama A, Okano A, Feng Y, Collins JC, Collins KC, Walsh CT, Boger DL. Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate. Organic Letters. 16: 3572-5. PMID 24954524 DOI: 10.1021/Ol501568T  0.359
2014 Walsh CT. Blurring the lines between ribosomal and nonribosomal peptide scaffolds. Acs Chemical Biology. 9: 1653-61. PMID 24883916 DOI: 10.1021/Cb5003587  0.373
2014 Li B, Wever WJ, Walsh CT, Bowers AA. Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Natural Product Reports. 31: 905-23. PMID 24835149 DOI: 10.1039/C3Np70106A  0.805
2014 Khosla C, Herschlag D, Cane DE, Walsh CT. Assembly line polyketide synthases: mechanistic insights and unsolved problems. Biochemistry. 53: 2875-83. PMID 24779441 DOI: 10.1021/Bi500290T  0.535
2014 Lim FY, Ames B, Walsh CT, Keller NP. Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus. Cellular Microbiology. 16: 1267-83. PMID 24612080 DOI: 10.1111/Cmi.12284  0.752
2014 Adachi Y, Mochida G, Walsh C, Barkovich J. Posterior fossa in primary microcephaly: Relationships between forebrain and mid-hindbrain size in 110 patients Neuropediatrics. 45: 93-101. PMID 24234199 DOI: 10.1055/S-0033-1360483  0.598
2014 Walsh CT, Wencewicz TA. Prospects for new antibiotics: a molecule-centered perspective. The Journal of Antibiotics. 67: 7-22. PMID 23756684 DOI: 10.1038/Ja.2013.49  0.67
2013 Gao X, Jiang W, Jiménez-Osés G, Choi MS, Houk KN, Tang Y, Walsh CT. An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins. Chemistry & Biology. 20: 870-8. PMID 23890005 DOI: 10.1016/J.Chembiol.2013.04.019  0.542
2013 Walsh CT, O'Brien RV, Khosla C. Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angewandte Chemie (International Ed. in English). 52: 7098-124. PMID 23729217 DOI: 10.1002/Anie.201208344  0.382
2013 Walsh CT, Haynes SW, Ames BD, Gao X, Tang Y. Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. Acs Chemical Biology. 8: 1366-82. PMID 23659680 DOI: 10.1021/Cb4001684  0.784
2013 Malcolmson SJ, Young TS, Ruby JG, Skewes-Cox P, Walsh CT. The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds. Proceedings of the National Academy of Sciences of the United States of America. 110: 8483-8. PMID 23650400 DOI: 10.1073/Pnas.1307111110  0.789
2013 Jiang W, Cacho RA, Chiou G, Garg NK, Tang Y, Walsh CT. EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold. Journal of the American Chemical Society. 135: 4457-66. PMID 23451921 DOI: 10.1021/Ja312572V  0.471
2013 Haynes SW, Gao X, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. Acs Chemical Biology. 8: 741-8. PMID 23330675 DOI: 10.1021/Cb3006787  0.527
2013 Parker JB, Walsh CT. Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin. Biochemistry. 52: 889-901. PMID 23317005 DOI: 10.1021/Bi3016229  0.409
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Walsh CT, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.791
2013 Walsh CT, Wencewicz TA. Flavoenzymes: versatile catalysts in biosynthetic pathways. Natural Product Reports. 30: 175-200. PMID 23051833 DOI: 10.1039/C2Np20069D  0.695
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Walsh CT, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.79
2013 Walsh CT, O'Brien RV, Khosla C. Nichtproteinogene Aminosäurebausteine für Peptidgerüste aus nichtribosomalen Peptiden und hybriden Polyketiden Angewandte Chemie. 125: 7238-7265. DOI: 10.1002/Ange.201208344  0.312
2012 Young TS, Dorrestein PC, Walsh CT. Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chemistry & Biology. 19: 1600-10. PMID 23261603 DOI: 10.1016/J.Chembiol.2012.10.013  0.8
2012 Li B, Forseth RR, Bowers AA, Schroeder FC, Walsh CT. A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus. Chembiochem : a European Journal of Chemical Biology. 13: 2521-6. PMID 23097183 DOI: 10.1002/Cbic.201200536  0.651
2012 Haynes SW, Gao X, Tang Y, Walsh CT. Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. Journal of the American Chemical Society. 134: 17444-7. PMID 23030663 DOI: 10.1021/Ja308371Z  0.466
2012 Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Journal of the American Chemical Society. 134: 16781-90. PMID 22998630 DOI: 10.1021/Ja307220Z  0.477
2012 Wencewicz TA, Walsh CT. Pseudomonas syringae self-protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr. Biochemistry. 51: 7712-25. PMID 22994681 DOI: 10.1021/Bi3011384  0.673
2012 Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y. Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nature Chemical Biology. 8: 823-30. PMID 22902615 DOI: 10.1038/Nchembio.1047  0.801
2012 Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chemistry & Biology. 19: 855-65. PMID 22840773 DOI: 10.1016/J.Chembiol.2012.05.016  0.361
2012 Parker JB, Walsh CT. Stereochemical outcome at four stereogenic centers during conversion of prephenate to tetrahydrotyrosine by BacABGF in the bacilysin pathway. Biochemistry. 51: 5622-32. PMID 22765234 DOI: 10.1021/Bi3006362  0.303
2012 Bowers AA, Acker MG, Young TS, Walsh CT. Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. Journal of the American Chemical Society. 134: 10313-6. PMID 22686940 DOI: 10.1021/ja302820x  0.807
2012 Parker JB, Walsh CT. Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis. Biochemistry. 51: 3241-51. PMID 22483065 DOI: 10.1021/Bi300254U  0.316
2012 Walsh CT, Malcolmson SJ, Young TS. Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. Acs Chemical Biology. 7: 429-42. PMID 22206579 DOI: 10.1021/Cb200518N  0.807
2012 Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Löhr F, Güntert P, Dötsch V. Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. Acs Chemical Biology. 7: 378-86. PMID 22103656 DOI: 10.1021/Cb200352Q  0.588
2012 Walsh CT, Haynes SW, Ames BD. Aminobenzoates as building blocks for natural product assembly lines. Natural Product Reports. 29: 37-59. PMID 22064917 DOI: 10.1039/C1Np00072A  0.771
2012 Garneau-Tsodikova S, Walsh CT. Editorial: Natural products themed issue Medchemcomm. 3: 852-853. DOI: 10.1039/C2Md90031A  0.524
2011 Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CT. Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. Chemistry & Biology. 18: 1102-12. PMID 21944749 DOI: 10.1016/J.Chembiol.2011.07.009  0.794
2011 Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/Bi201302W  0.816
2011 Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J. NRPS substrate promiscuity diversifies the xenematides. Organic Letters. 13: 5144-7. PMID 21888371 DOI: 10.1021/Ol2020237  0.39
2011 Walsh CT, Zhang W. Chemical logic and enzymatic machinery for biological assembly of peptidyl nucleoside antibiotics. Acs Chemical Biology. 6: 1000-7. PMID 21851099 DOI: 10.1021/Cb200284P  0.486
2011 Wuest WM, Krahn D, Kaiser M, Walsh CT. Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesis. Organic Letters. 13: 4518-21. PMID 21812451 DOI: 10.1021/Ol2016687  0.612
2011 Young TS, Walsh CT. Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans. Proceedings of the National Academy of Sciences of the United States of America. 108: 13053-8. PMID 21788474 DOI: 10.1073/Pnas.1110435108  0.821
2011 Zhang W, Ntai I, Kelleher NL, Walsh CT. tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 108: 12249-53. PMID 21746899 DOI: 10.1073/Pnas.1109539108  0.817
2011 Jiang W, Heemstra JR, Forseth RR, Neumann CS, Manaviazar S, Schroeder FC, Hale KJ, Walsh CT. Biosynthetic chlorination of the piperazate residue in kutzneride biosynthesis by KthP. Biochemistry. 50: 6063-72. PMID 21648411 DOI: 10.1021/Bi200656K  0.359
2011 Zhang W, Ames BD, Walsh CT. Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis. Biochemistry. 50: 5401-3. PMID 21615132 DOI: 10.1021/Bi200733C  0.793
2011 Haynes SW, Ames BD, Gao X, Tang Y, Walsh CT. Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry. 50: 5668-79. PMID 21591693 DOI: 10.1021/Bi2004922  0.788
2011 Hollenhorst MA, Ntai I, Badet B, Kelleher NL, Walsh CT. A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway. Biochemistry. 50: 3859-61. PMID 21520904 DOI: 10.1021/Bi2004735  0.806
2011 Li B, Walsh CT. Streptomyces clavuligerus HlmI is an intramolecular disulfide-forming dithiol oxidase in holomycin biosynthesis. Biochemistry. 50: 4615-22. PMID 21504228 DOI: 10.1021/Bi200321C  0.5
2011 Balskus EP, Case RJ, Walsh CT. The biosynthesis of cyanobacterial sunscreen scytonemin in intertidal microbial mat communities. Fems Microbiology Ecology. 77: 322-32. PMID 21501195 DOI: 10.1111/J.1574-6941.2011.01113.X  0.569
2011 Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. Journal of the American Chemical Society. 133: 5240-3. PMID 21417270 DOI: 10.1021/Ja2011109  0.83
2011 Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41. PMID 21299212 DOI: 10.1021/Ja1101085  0.799
2011 Frueh DP, Nichols S, Mishra S, Arthanari H, Koglin A, Walsh CT, Wagner G. Transient Domain Interactions in Non-Ribosomal Peptide Synthetases Biophysical Journal. 100: 17a. DOI: 10.1016/J.Bpj.2010.12.305  0.372
2010 Li B, Walsh CT. Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus. Proceedings of the National Academy of Sciences of the United States of America. 107: 19731-5. PMID 21041678 DOI: 10.1073/Pnas.1014140107  0.456
2010 Imker HJ, Krahn D, Clerc J, Kaiser M, Walsh CT. N-acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF. Chemistry & Biology. 17: 1077-83. PMID 21035730 DOI: 10.1016/J.Chembiol.2010.08.007  0.389
2010 Zhang W, Heemstra JR, Walsh CT, Imker HJ. Activation of the pacidamycin PacL adenylation domain by MbtH-like proteins. Biochemistry. 49: 9946-7. PMID 20964365 DOI: 10.1021/Bi101539B  0.505
2010 Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Kelleher NL, Walsh CT. The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. Journal of the American Chemical Society. 132: 15773-81. PMID 20945916 DOI: 10.1021/Ja1072367  0.785
2010 Mahlstedt S, Fielding EN, Moore BS, Walsh CT. Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. Biochemistry. 49: 9021-3. PMID 20863139 DOI: 10.1021/Bi101457H  0.806
2010 Zhang W, Ostash B, Walsh CT. Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 107: 16828-33. PMID 20826445 DOI: 10.1073/Pnas.1011557107  0.505
2010 Balskus EP, Walsh CT. The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria. Science (New York, N.Y.). 329: 1653-6. PMID 20813918 DOI: 10.1126/Science.1193637  0.613
2010 Ames BD, Liu X, Walsh CT. Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis. Biochemistry. 49: 8564-76. PMID 20804163 DOI: 10.1021/Bi1012029  0.78
2010 Bowers AA, Walsh CT, Acker MG. Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus. Journal of the American Chemical Society. 132: 12182-4. PMID 20707374 DOI: 10.1021/Ja104524Q  0.674
2010 Walsh CT, Acker MG, Bowers AA. Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins. The Journal of Biological Chemistry. 285: 27525-31. PMID 20522549 DOI: 10.1074/Jbc.R110.135970  0.7
2010 Bowers AA, Acker MG, Koglin A, Walsh CT. Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. Journal of the American Chemical Society. 132: 7519-27. PMID 20455532 DOI: 10.1021/Ja102339Q  0.672
2010 Zhang W, Bolla ML, Kahne D, Walsh CT. A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis. Journal of the American Chemical Society. 132: 6402-11. PMID 20394362 DOI: 10.1021/Ja1002845  0.52
2010 Neumann CS, Walsh CT, Kay RR. A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1. Proceedings of the National Academy of Sciences of the United States of America. 107: 5798-803. PMID 20231486 DOI: 10.1073/Pnas.1001681107  0.322
2010 Ames BD, Walsh CT. Anthranilate-activating modules from fungal nonribosomal peptide assembly lines. Biochemistry. 49: 3351-65. PMID 20225828 DOI: 10.1021/Bi100198Y  0.781
2010 Walsh CT, Fischbach MA. Natural products version 2.0: connecting genes to molecules. Journal of the American Chemical Society. 132: 2469-93. PMID 20121095 DOI: 10.1021/Ja909118A  0.579
2010 Mahlstedt SA, Walsh CT. Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis. Biochemistry. 49: 912-23. PMID 20052993 DOI: 10.1021/Bi9021186  0.828
2010 Gómez García I, Stevenson CE, Usón I, Freel Meyers CL, Walsh CT, Lawson DM. The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily. Journal of Molecular Biology. 395: 390-407. PMID 19857499 DOI: 10.1016/J.Jmb.2009.10.045  0.74
2010 Hollenhorst MA, Clardy J, Walsh CT. Correction to The ATP-Dependent Amide Ligases DdaG and DdaF Assemble the Fumaramoyl-Dipeptide Scaffold of the Dapdiamide Antibiotics Biochemistry. 49: 1808-1808. DOI: 10.1021/Bi100095K  0.758
2009 Imker HJ, Walsh CT, Wuest WM. SylC catalyzes ureido-bond formation during biosynthesis of the proteasome inhibitor syringolin A. Journal of the American Chemical Society. 131: 18263-5. PMID 19968303 DOI: 10.1021/Ja909170U  0.66
2009 Acker MG, Bowers AA, Walsh CT. Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. Journal of the American Chemical Society. 131: 17563-5. PMID 19911780 DOI: 10.1021/Ja908777T  0.668
2009 Liu X, Walsh CT. Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies. Biochemistry. 48: 11032-44. PMID 19877600 DOI: 10.1021/Bi901597J  0.532
2009 Matthews ML, Neumann CS, Miles LA, Grove TL, Booker SJ, Krebs C, Walsh CT, Bollinger JM. Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. Proceedings of the National Academy of Sciences of the United States of America. 106: 17723-8. PMID 19815524 DOI: 10.1073/Pnas.0909649106  0.712
2009 Hollenhorst MA, Clardy J, Walsh CT. The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Biochemistry. 48: 10467-72. PMID 19807062 DOI: 10.1021/Bi9013165  0.788
2009 Balskus EP, Walsh CT. An enzymatic cyclopentyl[b]indole formation involved in scytonemin biosynthesis. Journal of the American Chemical Society. 131: 14648-9. PMID 19780555 DOI: 10.1021/Ja906752U  0.639
2009 Heemstra JR, Walsh CT, Sattely ES. Enzymatic tailoring of ornithine in the biosynthesis of the Rhizobium cyclic trihydroxamate siderophore vicibactin. Journal of the American Chemical Society. 131: 15317-29. PMID 19778043 DOI: 10.1021/Ja9056008  0.69
2009 Walsh CT, Wright GD. Antimicrobials. Current Opinion in Microbiology. 12: 473-5. PMID 19733112 DOI: 10.1016/j.mib.2009.08.002  0.571
2009 Strieker M, Nolan EM, Walsh CT, Marahiel MA. Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. Journal of the American Chemical Society. 131: 13523-30. PMID 19722489 DOI: 10.1021/Ja9054417  0.721
2009 Fischbach MA, Walsh CT. Antibiotics for emerging pathogens. Science (New York, N.Y.). 325: 1089-93. PMID 19713519 DOI: 10.1126/Science.1176667  0.553
2009 Frueh DP, Arthanari H, Koglin A, Walsh CT, Wagner G. A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins. Journal of the American Chemical Society. 131: 12880-1. PMID 19702261 DOI: 10.1021/Ja9046685  0.308
2009 Liu X, Walsh CT. Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan. Biochemistry. 48: 8746-57. PMID 19663400 DOI: 10.1021/Bi901123R  0.474
2009 Koglin A, Walsh CT. Structural insights into nonribosomal peptide enzymatic assembly lines. Natural Product Reports. 26: 987-1000. PMID 19636447 DOI: 10.1039/B904543K  0.411
2009 Walsh CT, Fischbach MA. New ways to squash superbugs. Scientific American. 301: 44-51. PMID 19555023 DOI: 10.1038/Scientificamerican0709-44  0.541
2009 Regni CA, Roush RF, Miller DJ, Nourse A, Walsh CT, Schulman BA. How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. The Embo Journal. 28: 1953-64. PMID 19494832 DOI: 10.1038/Emboj.2009.146  0.833
2009 Wuest WM, Sattely ES, Walsh CT. Three siderophores from one bacterial enzymatic assembly line. Journal of the American Chemical Society. 131: 5056-7. PMID 19320483 DOI: 10.1021/Ja900815W  0.767
2009 Wong C, Fujimori DG, Walsh CT, Drennan CL. Structural analysis of an open active site conformation of nonheme iron halogenase CytC3. Journal of the American Chemical Society. 131: 4872-9. PMID 19281171 DOI: 10.1021/Ja8097355  0.688
2009 Matthews ML, Krest CM, Barr EW, Vaillancourt FH, Walsh CT, Green MT, Krebs C, Bollinger JM. Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Biochemistry. 48: 4331-43. PMID 19245217 DOI: 10.1021/Bi900109Z  0.728
2009 Strieter ER, Koglin A, Aron ZD, Walsh CT. Cascade reactions during coronafacic acid biosynthesis: elongation, cyclization, and functionalization during Cfa7-catalyzed condensation. Journal of the American Chemical Society. 131: 2113-5. PMID 19199623 DOI: 10.1021/Ja8077945  0.727
2009 Wieland Brown LC, Acker MG, Clardy J, Walsh CT, Fischbach MA. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proceedings of the National Academy of Sciences of the United States of America. 106: 2549-53. PMID 19196969 DOI: 10.1073/Pnas.0900008106  0.628
2009 Walsh CT, Fischbach MA. Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery. Proceedings of the National Academy of Sciences of the United States of America. 106: 1689-90. PMID 19193851 DOI: 10.1073/Pnas.0813405106  0.55
2009 Altmann KH, Buchner J, Kessler H, Diederich F, Kräutler B, Lippard S, Liskamp R, Müller K, Nolan EM, Samori B, Schneider G, Schreiber SL, Schwalbe H, Toniolo C, van Boeckel CA, ... ... Walsh CT, et al. The state of the art of chemical biology. Chembiochem : a European Journal of Chemical Biology. 10: 16-29. PMID 19115274 DOI: 10.1002/cbic.200800758  0.614
2009 Nolan EM, Walsh CT. How nature morphs peptide scaffolds into antibiotics. Chembiochem : a European Journal of Chemical Biology. 10: 34-53. PMID 19058272 DOI: 10.1002/Cbic.200800438  0.617
2008 Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL. The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction. Biochemistry. 47: 13506-13. PMID 19035832 DOI: 10.1021/Bi801229W  0.353
2008 Gómez García I, Freel Meyers CL, Walsh CT, Lawson DM. Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 1000-2. PMID 18997325 DOI: 10.1107/S1744309108030145  0.663
2008 Balskus EP, Walsh CT. Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin. Journal of the American Chemical Society. 130: 15260-1. PMID 18954141 DOI: 10.1021/Ja807192U  0.62
2008 Neumann CS, Walsh CT. Biosynthesis of (-)-(1S,2R)-allocoronamic acyl thioester by an Fe(II)-dependent halogenase and a cyclopropane-forming flavoprotein. Journal of the American Chemical Society. 130: 14022-3. PMID 18828590 DOI: 10.1021/Ja8064667  0.388
2008 Heemstra JR, Walsh CT. Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly. Journal of the American Chemical Society. 130: 14024-5. PMID 18828589 DOI: 10.1021/Ja806467A  0.323
2008 Singh GM, Fortin PD, Koglin A, Walsh CT. beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae. Biochemistry. 47: 11310-20. PMID 18826255 DOI: 10.1021/Bi801322Z  0.686
2008 Liu X, Fortin PD, Walsh CT. Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic. Proceedings of the National Academy of Sciences of the United States of America. 105: 13321-6. PMID 18768797 DOI: 10.1073/Pnas.0806873105  0.451
2008 Calderone CT, Bumpus SB, Kelleher NL, Walsh CT, Magarvey NA. A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth. Proceedings of the National Academy of Sciences of the United States of America. 105: 12809-14. PMID 18723688 DOI: 10.1073/Pnas.0806305105  0.782
2008 Sattely ES, Walsh CT. A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis. Journal of the American Chemical Society. 130: 12282-4. PMID 18710233 DOI: 10.1021/Ja804499R  0.667
2008 Koglin A, Löhr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Güntert P, Wagner G, Walsh CT, Marahiel MA, Dötsch V. Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature. 454: 907-11. PMID 18704089 DOI: 10.1038/Nature07161  0.784
2008 Frueh DP, Arthanari H, Koglin A, Vosburg DA, Bennett AE, Walsh CT, Wagner G. Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature. 454: 903-6. PMID 18704088 DOI: 10.1038/Nature07162  0.72
2008 Bumpus SB, Magarvey NA, Kelleher NL, Walsh CT, Calderone CT. Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis. Journal of the American Chemical Society. 130: 11614-6. PMID 18693732 DOI: 10.1021/Ja8040042  0.805
2008 Nolan EM, Walsh CT. Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: linkage of ribosomal and nonribosomal peptides to form "trojan horse" antibiotics. Biochemistry. 47: 9289-99. PMID 18690711 DOI: 10.1021/Bi800826J  0.674
2008 Sattely ES, Fischbach MA, Walsh CT. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Natural Product Reports. 25: 757-93. PMID 18663394 DOI: 10.1039/B801747F  0.773
2008 Magarvey NA, Fortin PD, Thomas PM, Kelleher NL, Walsh CT. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. Acs Chemical Biology. 3: 542-54. PMID 18652473 DOI: 10.1021/Cb800085G  0.805
2008 Zhou Z, Koglin A, Wang Y, McMahon AP, Walsh CT. An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. Journal of the American Chemical Society. 130: 9925-30. PMID 18593165 DOI: 10.1021/Ja802657N  0.399
2008 Walsh CT, Fischbach MA. Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics. Angewandte Chemie (International Ed. in English). 47: 5700-2. PMID 18576462 DOI: 10.1002/Anie.200801801  0.6
2008 Walsh CT, Nolan EM. Morphing peptide backbones into heterocycles. Proceedings of the National Academy of Sciences of the United States of America. 105: 5655-6. PMID 18398003 DOI: 10.1073/Pnas.0802300105  0.635
2008 Neumann CS, Fujimori DG, Walsh CT. Halogenation strategies in natural product biosynthesis. Chemistry & Biology. 15: 99-109. PMID 18291314 DOI: 10.1016/J.Chembiol.2008.01.006  0.665
2008 Roush RF, Nolan EM, Löhr F, Walsh CT. Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7. Journal of the American Chemical Society. 130: 3603-9. PMID 18290647 DOI: 10.1021/Ja7101949  0.813
2008 Fischbach MA, Walsh CT, Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proceedings of the National Academy of Sciences of the United States of America. 105: 4601-8. PMID 18216259 DOI: 10.1073/Pnas.0709132105  0.545
2008 Strieker M, Essen LO, Walsh CT, Marahiel MA. Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. Chembiochem : a European Journal of Chemical Biology. 9: 374-6. PMID 18213565 DOI: 10.1002/Cbic.200700557  0.519
2008 Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL. The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins. The Journal of Biological Chemistry. 283: 6467-75. PMID 18171675 DOI: 10.1074/Jbc.M708573200  0.751
2008 Balibar CJ, Walsh CT. From thioesters to amides and back: condensation domain reversibility in the biosynthesis of vibriobactin. Chembiochem : a European Journal of Chemical Biology. 9: 42-5. PMID 18022888 DOI: 10.1002/Cbic.200700485  0.713
2008 Walsh CT. The chemical versatility of natural-product assembly lines. Accounts of Chemical Research. 41: 4-10. PMID 17506516 DOI: 10.1021/Ar7000414  0.396
2008 Roush RF, Nolan EM, Löhr F, Walsh CT. Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7 (Journal of the American Chemical Society (2008) 130, (3603-3609)) Journal of the American Chemical Society. 130: 6055. DOI: 10.1021/ja802086j  0.797
2008 Walsh C, Fischbach M. Inhibitoren der Sterolbiosynthese als Antibiotika gegenStaphylococcus aureus Angewandte Chemie. 120: 5784-5786. DOI: 10.1002/Ange.200801801  0.499
2007 Read JA, Walsh CT. The lyngbyatoxin biosynthetic assembly line: chain release by four-electron reduction of a dipeptidyl thioester to the corresponding alcohol. Journal of the American Chemical Society. 129: 15762-3. PMID 18044902 DOI: 10.1021/Ja077374D  0.375
2007 Nolan EM, Fischbach MA, Koglin A, Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. Journal of the American Chemical Society. 129: 14336-47. PMID 17973380 DOI: 10.1021/Ja074650F  0.736
2007 Neidig ML, Brown CD, Light KM, Fujimori DG, Nolan EM, Price JC, Barr EW, Bollinger JM, Krebs C, Walsh CT, Solomon EI. CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases. Journal of the American Chemical Society. 129: 14224-31. PMID 17967013 DOI: 10.1021/Ja074557R  0.79
2007 Fujimori DG, Hrvatin S, Neumann CS, Strieker M, Marahiel MA, Walsh CT. Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proceedings of the National Academy of Sciences of the United States of America. 104: 16498-503. PMID 17940045 DOI: 10.1073/Pnas.0708242104  0.763
2007 Fujimori DG, Barr EW, Matthews ML, Koch GM, Yonce JR, Walsh CT, Bollinger JM, Krebs C, Riggs-Gelasco PJ. Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces. Journal of the American Chemical Society. 129: 13408-9. PMID 17939667 DOI: 10.1021/Ja076454E  0.773
2007 Fujimori DG, Walsh CT. What's new in enzymatic halogenations. Current Opinion in Chemical Biology. 11: 553-60. PMID 17881282 DOI: 10.1016/J.Cbpa.2007.08.002  0.68
2007 Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL. Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC. Proceedings of the National Academy of Sciences of the United States of America. 104: 15311-6. PMID 17873060 DOI: 10.1073/Pnas.0707190104  0.378
2007 Balibar CJ, Howard-Jones AR, Walsh CT. Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation. Nature Chemical Biology. 3: 584-92. PMID 17704773 DOI: 10.1038/Nchembio.2007.20  0.752
2007 Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D. Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. Journal of the American Chemical Society. 129: 10546-50. PMID 17685523 DOI: 10.1021/Ja072909O  0.32
2007 Howard-Jones AR, Kruger RG, Lu W, Tao J, Leimkuhler C, Kahne D, Walsh CT. Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. Journal of the American Chemical Society. 129: 10082-3. PMID 17661468 DOI: 10.1021/Ja0735857  0.37
2007 Calderone CT, Iwig DF, Dorrestein PC, Kelleher NL, Walsh CT. Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chemistry & Biology. 14: 835-46. PMID 17656320 DOI: 10.1016/J.Chembiol.2007.06.008  0.777
2007 Fortin PD, Walsh CT, Magarvey NA. A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines. Nature. 448: 824-7. PMID 17653193 DOI: 10.1038/Nature06068  0.731
2007 Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proceedings of the National Academy of Sciences of the United States of America. 104: 11951-6. PMID 17620609 DOI: 10.1073/Pnas.0705348104  0.759
2007 Zhou Z, Lai JR, Walsh CT. Directed evolution of aryl carrier proteins in the enterobactin synthetase. Proceedings of the National Academy of Sciences of the United States of America. 104: 11621-6. PMID 17606920 DOI: 10.1073/Pnas.0705122104  0.618
2007 Balibar CJ, Garneau-Tsodikova S, Walsh CT. Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis. Chemistry & Biology. 14: 679-90. PMID 17584615 DOI: 10.1016/J.Chembiol.2007.05.007  0.803
2007 Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. Biochemistry. 46: 8462-71. PMID 17580964 DOI: 10.1021/Bi700433V  0.79
2007 Krebs C, Galonić Fujimori D, Walsh CT, Bollinger JM. Non-heme Fe(IV)-oxo intermediates. Accounts of Chemical Research. 40: 484-92. PMID 17542550 DOI: 10.1021/Ar700066P  0.572
2007 Strieter ER, Vaillancourt FH, Walsh CT. CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway. Biochemistry. 46: 7549-57. PMID 17530782 DOI: 10.1021/Bi700243H  0.703
2007 Pacholec M, Sello JK, Walsh CT, Thomas MG. Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol. Organic & Biomolecular Chemistry. 5: 1692-4. PMID 17520135 DOI: 10.1039/B703356G  0.812
2007 Hansen DB, Bumpus SB, Aron ZD, Kelleher NL, Walsh CT. The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity. Journal of the American Chemical Society. 129: 6366-7. PMID 17472382 DOI: 10.1021/Ja070890J  0.787
2007 Zhou Z, Cironi P, Lin AJ, Xu Y, Hrvatin S, Golan DE, Silver PA, Walsh CT, Yin J. Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. Acs Chemical Biology. 2: 337-46. PMID 17465518 DOI: 10.1021/Cb700054K  0.534
2007 Yin J, Straight PD, Hrvatin S, Dorrestein PC, Bumpus SB, Jao C, Kelleher NL, Kolter R, Walsh CT. Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chemistry & Biology. 14: 303-12. PMID 17379145 DOI: 10.1016/J.Chembiol.2007.01.006  0.796
2007 Stevenson CE, Freel Meyers CL, Walsh CT, Lawson DM. Crystallization and preliminary X-ray analysis of the O-methyltransferase NovP from the novobiocin-biosynthetic cluster of Streptomyces spheroides. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 236-8. PMID 17329822 DOI: 10.1107/S1744309107008287  0.704
2007 Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT. Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry. 46: 1284-92. PMID 17260957 DOI: 10.1021/Bi0621213  0.602
2007 Singh GM, Vaillancourt FH, Yin J, Walsh CT. Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line. Chemistry & Biology. 14: 31-40. PMID 17254950 DOI: 10.1016/J.Chembiol.2006.11.005  0.766
2007 Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 104: 1506-9. PMID 17234808 DOI: 10.1073/Pnas.0610503104  0.619
2007 Galonić DP, Barr EW, Walsh CT, Bollinger JM, Krebs C. Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. Nature Chemical Biology. 3: 113-6. PMID 17220900 DOI: 10.1038/Nchembio856  0.588
2007 Kelly WL, Boyne MT, Yeh E, Vosburg DA, Galoni? DP, Kelleher NL, Walsh CT. Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. Biochemistry. 46: 359-68. PMID 17209546 DOI: 10.1021/Bi061930J  0.81
2007 Straight PD, Fischbach MA, Walsh CT, Rudner DZ, Kolter R. A singular enzymatic megacomplex from Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 104: 305-10. PMID 17190806 DOI: 10.1073/Pnas.0609073103  0.619
2006 Yin J, Lin AJ, Golan DE, Walsh CT. Site-specific protein labeling by Sfp phosphopantetheinyl transferase. Nature Protocols. 1: 280-5. PMID 17406245 DOI: 10.1038/Nprot.2006.43  0.519
2006 Balibar CJ, Walsh CT. In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. Biochemistry. 45: 15444-57. PMID 17176066 DOI: 10.1021/Bi061998Z  0.745
2006 Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. Acs Chemical Biology. 1: 29-32. PMID 17163637 DOI: 10.1021/Cb0500034  0.699
2006 Clardy J, Fischbach MA, Walsh CT. New antibiotics from bacterial natural products. Nature Biotechnology. 24: 1541-50. PMID 17160060 DOI: 10.1038/Nbt1266  0.565
2006 Balibar CJ, Walsh CT. GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin. Biochemistry. 45: 15029-38. PMID 17154540 DOI: 10.1021/Bi061845B  0.729
2006 Lai JR, Koglin A, Walsh CT. Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis. Biochemistry. 45: 14869-79. PMID 17154525 DOI: 10.1021/Bi061979P  0.615
2006 Ueki M, Galoni? DP, Vaillancourt FH, Garneau-Tsodikova S, Yeh E, Vosburg DA, Schroeder FC, Osada H, Walsh CT. Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. Chemistry & Biology. 13: 1183-91. PMID 17114000 DOI: 10.1016/J.Chembiol.2006.09.012  0.812
2006 Fischbach MA, Walsh CT. Biochemistry. Directing biosynthesis. Science (New York, N.Y.). 314: 603-5. PMID 17068249 DOI: 10.1126/Science.1132692  0.553
2006 Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proceedings of the National Academy of Sciences of the United States of America. 103: 16502-7. PMID 17060628 DOI: 10.1073/Pnas.0604636103  0.719
2006 Dorrestein PC, Bumpus SB, Calderone CT, Garneau-Tsodikova S, Aron ZD, Straight PD, Kolter R, Walsh CT, Kelleher NL. Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry. 45: 12756-66. PMID 17042494 DOI: 10.1021/Bi061169D  0.818
2006 Garneau-Tsodikova S, Dorrestein PC, Kelleher NL, Walsh CT. Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society. 128: 12600-1. PMID 17002325 DOI: 10.1021/Ja063611L  0.807
2006 Howard-Jones AR, Walsh CT. Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid. Journal of the American Chemical Society. 128: 12289-98. PMID 16967980 DOI: 10.1021/Ja063898M  0.395
2006 Zhou Z, Lai JR, Walsh CT. Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection. Chemistry & Biology. 13: 869-79. PMID 16931336 DOI: 10.1016/j.chembiol.2006.06.011  0.511
2006 Lai JR, Fischbach MA, Liu DR, Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. Journal of the American Chemical Society. 128: 11002-3. PMID 16925399 DOI: 10.1021/Ja063238H  0.729
2006 Larsen NA, Lin H, Wei R, Fischbach MA, Walsh CT. Structural characterization of enterobactin hydrolase IroE. Biochemistry. 45: 10184-90. PMID 16922493 DOI: 10.1021/bi060950i  0.683
2006 Magarvey NA, Ehling-Schulz M, Walsh CT. Characterization of the cereulide NRPS alpha-hydroxy acid specifying modules: activation of alpha-keto acids and chiral reduction on the assembly line. Journal of the American Chemical Society. 128: 10698-9. PMID 16910662 DOI: 10.1021/Ja0640187  0.66
2006 Fischbach MA, Walsh CT. Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chemical Reviews. 106: 3468-96. PMID 16895337 DOI: 10.1021/Cr0503097  0.575
2006 Vaillancourt FH, Yeh E, Vosburg DA, Garneau-Tsodikova S, Walsh CT. Nature's inventory of halogenation catalysts: oxidative strategies predominate. Chemical Reviews. 106: 3364-78. PMID 16895332 DOI: 10.1021/Cr050313I  0.76
2006 Walsh CT, Garneau-Tsodikova S, Howard-Jones AR. Biological formation of pyrroles: nature's logic and enzymatic machinery. Natural Product Reports. 23: 517-31. PMID 16874387 DOI: 10.1039/B605245M  0.576
2006 Lin H, Fischbach MA, Gatto GJ, Liu DR, Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. Journal of the American Chemical Society. 128: 9324-5. PMID 16848455 DOI: 10.1021/Ja063236X  0.723
2006 Garneau-Tsodikova S, Stapon A, Kahne D, Walsh CT. Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. Biochemistry. 45: 8568-78. PMID 16834331 DOI: 10.1021/Bi060784E  0.595
2006 Hicks LM, Balibar CJ, Walsh CT, Kelleher NL, Hillson NJ. Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry. Biophysical Journal. 91: 2609-19. PMID 16815901 DOI: 10.1529/Biophysj.106.084848  0.804
2006 Yeh E, Cole LJ, Barr EW, Bollinger JM, Ballou DP, Walsh CT. Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry. 45: 7904-12. PMID 16784243 DOI: 10.1021/Bi060607D  0.68
2006 Calderone CT, Kowtoniuk WE, Kelleher NL, Walsh CT, Dorrestein PC. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8977-82. PMID 16757561 DOI: 10.1073/Pnas.0603148103  0.754
2006 Frueh DP, Sun ZY, Vosburg DA, Walsh CT, Hoch JC, Wagner G. Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. Journal of the American Chemical Society. 128: 5757-63. PMID 16637644 DOI: 10.1021/Ja0584222  0.673
2006 Lai JR, Fischbach MA, Liu DR, Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proceedings of the National Academy of Sciences of the United States of America. 103: 5314-9. PMID 16567620 DOI: 10.1073/Pnas.0601038103  0.758
2006 Galonić DP, Vaillancourt FH, Walsh CT. Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis. Journal of the American Chemical Society. 128: 3900-1. PMID 16551084 DOI: 10.1021/Ja060151N  0.381
2006 Blasiak LC, Vaillancourt FH, Walsh CT, Drennan CL. Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature. 440: 368-71. PMID 16541079 DOI: 10.1038/Nature04544  0.312
2006 Gatto GJ, Boyne MT, Kelleher NL, Walsh CT. Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. Journal of the American Chemical Society. 128: 3838-47. PMID 16536560 DOI: 10.1021/Ja0587603  0.804
2006 Vaillancourt FH, Vosburg DA, Walsh CT. Dichlorination and bromination of a threonyl-S-carrier protein by the non-heme Fe(II) halogenase SyrB2. Chembiochem : a European Journal of Chemical Biology. 7: 748-52. PMID 16528784 DOI: 10.1002/Cbic.200500480  0.663
2006 Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chemical Communications (Cambridge, England). 1079-81. PMID 16514445 DOI: 10.1039/B515763C  0.695
2006 Frueh DP, Vosburg DA, Walsh CT, Wagner G. Determination of all nOes in 1H-13C-Me-ILV-U-2H-15N proteins with two time-shared experiments. Journal of Biomolecular Nmr. 34: 31-40. PMID 16505962 DOI: 10.1007/S10858-005-5338-4  0.685
2006 Fischbach MA, Lin H, Liu DR, Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nature Chemical Biology. 2: 132-8. PMID 16485005 DOI: 10.1038/Nchembio771  0.716
2006 Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 45: 1537-46. PMID 16460000 DOI: 10.1021/Bi052333K  0.813
2005 Howard-Jones AR, Walsh CT. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry. 44: 15652-63. PMID 16313168 DOI: 10.1021/Bi051706E  0.358
2005 Balibar CJ, Vaillancourt FH, Walsh CT. Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains. Chemistry & Biology. 12: 1189-200. PMID 16298298 DOI: 10.1016/J.Chembiol.2005.08.010  0.741
2005 Pacholec M, Tao J, Walsh CT. CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. Biochemistry. 44: 14969-76. PMID 16274243 DOI: 10.1021/Bi051599O  0.8
2005 Walsh CT, Garneau-Tsodikova S, Gatto GJ. Protein posttranslational modifications: the chemistry of proteome diversifications. Angewandte Chemie (International Ed. in English). 44: 7342-72. PMID 16267872 DOI: 10.1002/Anie.200501023  0.585
2005 Aron ZD, Dorrestein PC, Blackhall JR, Kelleher NL, Walsh CT. Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. Journal of the American Chemical Society. 127: 14986-7. PMID 16248612 DOI: 10.1021/Ja055247G  0.758
2005 McLoughlin SM, Mazur MT, Miller LM, Yin J, Liu F, Walsh CT, Kelleher NL. Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry. Biochemistry. 44: 14159-69. PMID 16245932 DOI: 10.1021/Bi051202G  0.811
2005 Yin J, Straight PD, McLoughlin SM, Zhou Z, Lin AJ, Golan DE, Kelleher NL, Kolter R, Walsh CT. Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 15815-20. PMID 16236721 DOI: 10.1073/Pnas.0507705102  0.807
2005 Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. Journal of the American Chemical Society. 127: 14128-9. PMID 16218575 DOI: 10.1021/Ja053704N  0.357
2005 Kelly WL, Hillson NJ, Walsh CT. Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity. Biochemistry. 44: 13385-93. PMID 16201763 DOI: 10.1021/Bi051124X  0.711
2005 Yin J, Lin AJ, Buckett PD, Wessling-Resnick M, Golan DE, Walsh CT. Single-cell FRET imaging of transferrin receptor trafficking dynamics by Sfp-catalyzed, site-specific protein labeling. Chemistry & Biology. 12: 999-1006. PMID 16183024 DOI: 10.1016/J.Chembiol.2005.07.006  0.473
2005 Pacholec M, Hillson NJ, Walsh CT. NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis. Biochemistry. 44: 12819-26. PMID 16171397 DOI: 10.1021/bi051297m  0.811
2005 Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT. Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 13843-8. PMID 16162666 DOI: 10.1073/Pnas.0506964102  0.804
2005 Vaillancourt FH, Yeh E, Vosburg DA, O'Connor SE, Walsh CT. Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature. 436: 1191-4. PMID 16121186 DOI: 10.1038/Nature03797  0.826
2005 Lin H, Fischbach MA, Liu DR, Walsh CT. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. Journal of the American Chemical Society. 127: 11075-84. PMID 16076215 DOI: 10.1021/Ja0522027  0.711
2005 Oberthür M, Leimkuhler C, Kruger RG, Lu W, Walsh CT, Kahne D. A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. Journal of the American Chemical Society. 127: 10747-52. PMID 16045364 DOI: 10.1021/Ja052945S  0.391
2005 Vaillancourt FH, Yin J, Walsh CT. SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10111-6. PMID 16002467 DOI: 10.1073/Pnas.0504412102  0.551
2005 Lu W, Leimkuhler C, Gatto GJ, Kruger RG, Oberthür M, Kahne D, Walsh CT. AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chemistry & Biology. 12: 527-34. PMID 15911373 DOI: 10.1016/J.Chembiol.2005.02.016  0.324
2005 Gatto GJ, McLoughlin SM, Kelleher NL, Walsh CT. Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme. Biochemistry. 44: 5993-6002. PMID 15835888 DOI: 10.1021/Bi050230W  0.823
2005 Pacholec M, Freel Meyers CL, Oberthür M, Kahne D, Walsh CT. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. Biochemistry. 44: 4949-56. PMID 15779922 DOI: 10.1021/Bi047303G  0.82
2005 Yeh E, Garneau S, Walsh CT. Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 3960-5. PMID 15743914 DOI: 10.1073/Pnas.0500755102  0.598
2005 Garneau S, Dorrestein PC, Kelleher NL, Walsh CT. Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry. 44: 2770-80. PMID 15723521 DOI: 10.1021/Bi0476329  0.763
2005 Walsh C, Wright G. Introduction: antibiotic resistance. Chemical Reviews. 105: 391-4. PMID 15700949 DOI: 10.1021/Cr030100Y  0.59
2005 Kruger RG, Lu W, Oberthür M, Tao J, Kahne D, Walsh CT. Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons. Chemistry & Biology. 12: 131-40. PMID 15664522 DOI: 10.1016/J.Chembiol.2004.12.005  0.348
2005 Vosburg DA, Walsh CT. Natural product biosynthetic assembly lines: prospects and challenges for reprogramming. Ernst Schering Research Foundation Workshop. 261-84. PMID 15645725  0.643
2005 Fischbach MA, Lin H, Liu DR, Walsh CT. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 571-6. PMID 15598734 DOI: 10.1073/Pnas.0408463102  0.711
2005 Leimkuhler C, Chen Z, Kruger RG, Oberthür M, Lu W, Walsh CT, Kahne D. Glycosylation of glycopeptides: A comparison of chemoenzymatic and chemical methods Tetrahedron Asymmetry. 16: 599-603. DOI: 10.1016/J.Tetasy.2004.12.006  0.31
2005 Walsh CT, Garneau-Tsodikova S, Gatto GJ. Posttranslationale Proteinmodifikation: die Chemie der Proteomdiversifizierung Angewandte Chemie. 117: 7508-7539. DOI: 10.1002/Ange.200501023  0.534
2004 Lin H, Thayer DA, Wong CH, Walsh CT. Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase. Chemistry & Biology. 11: 1635-42. PMID 15610847 DOI: 10.1016/J.Chembiol.2004.09.015  0.658
2004 Schneider TL, Walsh CT. Portability of oxidase domains in nonribosomal peptide synthetase modules. Biochemistry. 43: 15946-55. PMID 15595851 DOI: 10.1021/Bi0481139  0.719
2004 Yeh E, Lin H, Clugston SL, Kohli RM, Walsh CT. Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent. Chemistry & Biology. 11: 1573-82. PMID 15556008 DOI: 10.1016/J.Chembiol.2004.09.003  0.822
2004 Liu F, Garneau S, Walsh CT. Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation. Chemistry & Biology. 11: 1533-42. PMID 15556004 DOI: 10.1016/J.Chembiol.2004.08.017  0.391
2004 Freel Meyers CL, Oberthür M, Heide L, Kahne D, Walsh CT. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry. 43: 15022-36. PMID 15554710 DOI: 10.1021/Bi048457Z  0.746
2004 Lin H, Walsh CT. A chemoenzymatic approach to glycopeptide antibiotics. Journal of the American Chemical Society. 126: 13998-4003. PMID 15506762 DOI: 10.1021/Ja045147V  0.613
2004 Yin J, Liu F, Schinke M, Daly C, Walsh CT. Phagemid encoded small molecules for high throughput screening of chemical libraries. Journal of the American Chemical Society. 126: 13570-1. PMID 15493886 DOI: 10.1021/Ja045127T  0.494
2004 Tseng CC, Vaillancourt FH, Bruner SD, Walsh CT. DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway. Chemistry & Biology. 11: 1195-203. PMID 15380180 DOI: 10.1016/J.Chembiol.2004.06.012  0.756
2004 Reimmann C, Patel HM, Walsh CT, Haas D. PchC thioesterase optimizes nonribosomal biosynthesis of the peptide siderophore pyochelin in Pseudomonas aeruginosa. Journal of Bacteriology. 186: 6367-73. PMID 15375116 DOI: 10.1128/Jb.186.19.6367-6373.2004  0.642
2004 Yeh E, Kohli RM, Bruner SD, Walsh CT. Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated. Chembiochem : a European Journal of Chemical Biology. 5: 1290-3. PMID 15368584 DOI: 10.1002/Cbic.200400077  0.786
2004 Hillson NJ, Balibar CJ, Walsh CT. Catalytically inactive condensation domain C1 is responsible for the dimerization of the VibF subunit of vibriobactin synthetase. Biochemistry. 43: 11344-51. PMID 15366944 DOI: 10.1021/Bi0489199  0.811
2004 Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. 126: 9924-5. PMID 15303858 DOI: 10.1021/Ja048836F  0.376
2004 Pi N, Meyers CL, Pacholec M, Walsh CT, Leary JA. Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton. Proceedings of the National Academy of Sciences of the United States of America. 101: 10036-41. PMID 15218104 DOI: 10.1073/Pnas.0403526101  0.817
2004 Yin J, Liu F, Li X, Walsh CT. Labeling proteins with small molecules by site-specific posttranslational modification. Journal of the American Chemical Society. 126: 7754-5. PMID 15212504 DOI: 10.1021/Ja047749K  0.535
2004 Merkel AB, Major LL, Errey JC, Burkart MD, Field RA, Walsh CT, Naismith JH. The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme. The Journal of Biological Chemistry. 279: 32684-91. PMID 15159413 DOI: 10.1074/Jbc.M404091200  0.628
2004 Hicks LM, O'Connor SE, Mazur MT, Walsh CT, Kelleher NL. Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chemistry & Biology. 11: 327-35. PMID 15123262 DOI: 10.1016/J.Chembiol.2004.02.021  0.815
2004 Mulichak AM, Lu W, Losey HC, Walsh CT, Garavito RM. Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry. 43: 5170-80. PMID 15122882 DOI: 10.1021/Bi036130C  0.772
2004 Lu W, Oberthür M, Leimkuhler C, Tao J, Kahne D, Walsh CT. Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. Proceedings of the National Academy of Sciences of the United States of America. 101: 4390-5. PMID 15070728 DOI: 10.1073/Pnas.0400277101  0.375
2004 Walsh CT. Polyketide and nonribosomal peptide antibiotics: modularity and versatility. Science (New York, N.Y.). 303: 1805-10. PMID 15031493 DOI: 10.1126/Science.1094318  0.402
2004 Tseng CC, McLoughlin SM, Kelleher NL, Walsh CT. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. Biochemistry. 43: 970-80. PMID 14744141 DOI: 10.1021/Bi035714B  0.816
2004 Sieber SA, Tao J, Walsh CT, Marahiel MA. Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. Angewandte Chemie (International Ed. in English). 43: 493-8. PMID 14735544 DOI: 10.1002/Anie.200352787  0.681
2004 Couch R, O'Connor SE, Seidle H, Walsh CT, Parry R. Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine. Journal of Bacteriology. 186: 35-42. PMID 14679222 DOI: 10.1128/Jb.186.1.35-42.2004  0.629
2003 Mazur MT, Walsh CT, Kelleher NL. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. Biochemistry. 42: 13393-400. PMID 14621984 DOI: 10.1021/Bi035585Z  0.797
2003 Pfeifer BA, Wang CC, Walsh CT, Khosla C. Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Applied and Environmental Microbiology. 69: 6698-702. PMID 14602630 DOI: 10.1128/Aem.69.11.6698-6702.2003  0.354
2003 Admiraal SJ, Khosla C, Walsh CT. A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line. Journal of the American Chemical Society. 125: 13664-5. PMID 14599196 DOI: 10.1021/Ja0379060  0.339
2003 Clugston SL, Sieber SA, Marahiel MA, Walsh CT. Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. Biochemistry. 42: 12095-104. PMID 14556641 DOI: 10.1021/BI035090+  0.793
2003 Sieber SA, Walsh CT, Marahiel MA. Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. Journal of the American Chemical Society. 125: 10862-6. PMID 12952465 DOI: 10.1021/Ja0361852  0.719
2003 Patel HM, Tao J, Walsh CT. Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa. Biochemistry. 42: 10514-27. PMID 12950179 DOI: 10.1021/Bi034840C  0.641
2003 O'Connor SE, Walsh CT, Liu F. Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces. Angewandte Chemie (International Ed. in English). 42: 3917-21. PMID 12949868 DOI: 10.1002/Anie.200352077  0.509
2003 Tao J, Hu S, Pacholec M, Walsh CT. Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway. Organic Letters. 5: 3233-6. PMID 12943395 DOI: 10.1021/Ol035101R  0.791
2003 Schneider TL, Shen B, Walsh CT. Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. Biochemistry. 42: 9722-30. PMID 12911314 DOI: 10.1021/Bi034792W  0.74
2003 Watanabe K, Rude MA, Walsh CT, Khosla C. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 9774-8. PMID 12888623 DOI: 10.1073/Pnas.1632167100  0.408
2003 Walsh C, Freel Meyers CL, Losey HC. Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming. Journal of Medicinal Chemistry. 46: 3425-36. PMID 12877577 DOI: 10.1021/Jm030257I  0.772
2003 Jakimowicz P, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM. Crystallization and preliminary X-ray studies on the putative dTDP sugar epimerase NovW from the novobiocin biosynthetic cluster of Streptomyces spheroides. Acta Crystallographica. Section D, Biological Crystallography. 59: 1507-9. PMID 12876368 DOI: 10.1107/S0907444903012848  0.696
2003 Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM. Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 100: 9238-43. PMID 12874381 DOI: 10.1073/Pnas.1233577100  0.795
2003 Kohli RM, Burke MD, Tao J, Walsh CT. Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules. Journal of the American Chemical Society. 125: 7160-1. PMID 12797773 DOI: 10.1021/Ja0352202  0.645
2003 Walsh CT, Losey HC, Freel Meyers CL. Antibiotic glycosyltransferases. Biochemical Society Transactions. 31: 487-92. PMID 12773141 DOI: 10.1042/  0.763
2003 Walsh CT, O'Connor SE, Schneider TL. Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. Journal of Industrial Microbiology & Biotechnology. 30: 448-55. PMID 12707798 DOI: 10.1007/S10295-003-0044-2  0.778
2003 Meyers CLF, Oberthür M, Anderson JW, Kahne D, Walsh CT. Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin Biochemistry. 42: 4179-4189. PMID 12680772 DOI: 10.1021/Bi0340088  0.406
2003 Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society. 125: 3428-9. PMID 12643694 DOI: 10.1021/Ja0298646  0.718
2003 Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L. CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 2316-21. PMID 12618544 DOI: 10.1073/Pnas.0337708100  0.435
2003 Kohli RM, Walsh CT. Enzymology of acyl chain macrocyclization in natural product biosynthesis. Chemical Communications (Cambridge, England). 297-307. PMID 12613585 DOI: 10.1039/B208333G  0.676
2003 Hubbard BK, Walsh CT. Vancomycin assembly: nature's way. Angewandte Chemie (International Ed. in English). 42: 730-65. PMID 12596194 DOI: 10.1002/Anie.200390202  0.32
2003 Roche ED, Walsh CT. Dissection of the EntF condensation domain boundary and active site residues in nonribosomal peptide synthesis. Biochemistry. 42: 1334-44. PMID 12564937 DOI: 10.1021/Bi026867M  0.394
2003 Hillson NJ, Walsh CT. Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies. Biochemistry. 42: 766-75. PMID 12534289 DOI: 10.1021/Bi026903H  0.702
2003 Hicks L, Weinreb P, Konz D, Marahiel MA, Walsh CT, Kelleher NL. Fourier-transform mass spectrometry for detection of thioester-bound intermediates in unfractionated proteolytic mixtures of 80 and 191 kDa portions of Bacitracin A synthetase Analytica Chimica Acta. 496: 217-224. DOI: 10.1016/S0003-2670(03)01001-8  0.789
2002 Losey HC, Jiang J, Biggins JB, Oberthür M, Ye XY, Dong SD, Kahne D, Thorson JS, Walsh CT. Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chemistry & Biology. 9: 1305-14. PMID 12498883 DOI: 10.1016/S1074-5521(02)00270-3  0.81
2002 Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry. 41: 13350-9. PMID 12416979 DOI: 10.1021/Bi026592A  0.829
2002 Sieber SA, Linne U, Hillson NJ, Roche E, Walsh CT, Marahiel MA. Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chemistry & Biology. 9: 997-1008. PMID 12323374 DOI: 10.1016/S1074-5521(02)00214-4  0.805
2002 Schneider TL, Walsh CT, O'Connor SE. Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line. Journal of the American Chemical Society. 124: 11272-3. PMID 12236733 DOI: 10.1021/Ja0274498  0.798
2002 Kohli RM, Walsh CT, Burkart MD. Biomimetic synthesis and optimization of cyclic peptide antibiotics. Nature. 418: 658-61. PMID 12167866 DOI: 10.1038/Nature00907  0.743
2002 Dong SD, Oberthür M, Losey HC, Anderson JW, Eggert US, Peczuh MW, Walsh CT, Kahne D. The structural basis for induction of VanB resistance. Journal of the American Chemical Society. 124: 9064-5. PMID 12149006 DOI: 10.1021/Ja026342H  0.744
2002 Luo L, Kohli RM, Onishi M, Linne U, Marahiel MA, Walsh CT. Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B. Biochemistry. 41: 9184-96. PMID 12119033 DOI: 10.1021/Bi026047+  0.744
2002 Marshall CG, Burkart MD, Meray RK, Walsh CT. Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases. Biochemistry. 41: 8429-37. PMID 12081492 DOI: 10.1021/Bi0202575  0.624
2002 Merkel AB, Temple GK, Burkart MD, Losey HC, Beis K, Walsh CT, Naismith JH. Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway. Acta Crystallographica. Section D, Biological Crystallography. 58: 1226-8. PMID 12077451 DOI: 10.1107/S0907444902007382  0.812
2002 Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, Walsh CT, Wright GD. Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proceedings of the National Academy of Sciences of the United States of America. 99: 8962-7. PMID 12060705 DOI: 10.1073/Pnas.102285099  0.715
2002 Keating TA, Marshall CG, Walsh CT, Keating AE. The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains Nature Structural Biology. 9: 522-526. PMID 12055621 DOI: 10.1038/Nsb810  0.431
2002 Crosa JH, Walsh CT. Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microbiology and Molecular Biology Reviews : Mmbr. 66: 223-49. PMID 12040125 DOI: 10.1128/Mmbr.66.2.223-249.2002  0.38
2002 Bruner SD, Weber T, Kohli RM, Schwarzer D, Marahiel MA, Walsh CT, Stubbs MT. Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (London, England : 1993). 10: 301-10. PMID 12005429 DOI: 10.1016/S0969-2126(02)00716-5  0.824
2002 O'Connor SE, Chen H, Walsh CT. Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces. Biochemistry. 41: 5685-94. PMID 11969430 DOI: 10.1021/Bi020006W  0.655
2002 Admiraal SJ, Khosla C, Walsh CT. The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products. Biochemistry. 41: 5313-24. PMID 11955082 DOI: 10.1021/Bi0200312  0.343
2002 Miller DA, Luo L, Hillson N, Keating TA, Walsh CT. Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. Chemistry & Biology. 9: 333-44. PMID 11927258 DOI: 10.1016/S1074-5521(02)00115-1  0.756
2002 Walsh CT. Combinatorial biosynthesis of antibiotics: challenges and opportunities. Chembiochem : a European Journal of Chemical Biology. 3: 125-34. PMID 11921390 DOI: 10.1002/1439-7633(20020301)3:2/3<124::Aid-Cbic124>3.0.Co;2-J  0.35
2002 Thomas MG, Burkart MD, Walsh CT. Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chemistry & Biology. 9: 171-84. PMID 11880032 DOI: 10.1016/S1074-5521(02)00100-X  0.683
2002 Chen H, Hubbard BK, O'Connor SE, Walsh CT. Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics. Chemistry & Biology. 9: 103-12. PMID 11841943 DOI: 10.1016/S1074-5521(02)00090-X  0.614
2002 Kohli RM, Takagi J, Walsh CT. The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides. Proceedings of the National Academy of Sciences of the United States of America. 99: 1247-52. PMID 11805307 DOI: 10.1073/Pnas.251668398  0.649
2002 Marshall CG, Hillson NJ, Walsh CT. Catalytic mapping of the vibriobactin biosynthetic enzyme VibF. Biochemistry. 41: 244-50. PMID 11772022 DOI: 10.1021/Bi011852U  0.687
2001 Keating TA, Ehmann DE, Kohli RM, Marshall CG, Trauger JW, Walsh CT. Chain termination steps in nonribosomal peptide synthetase assembly lines: directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis. Chembiochem : a European Journal of Chemical Biology. 2: 99-107. PMID 11828432 DOI: 10.1002/1439-7633(20010202)2:2<99::Aid-Cbic99>3.0.Co;2-3  0.79
2001 Chen H, Tseng CC, Hubbard BK, Walsh CT. Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine. Proceedings of the National Academy of Sciences of the United States of America. 98: 14901-6. PMID 11752437 DOI: 10.1073/Pnas.221582098  0.625
2001 Luo L, Burkart MD, Stachelhaus T, Walsh CT. Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase. Journal of the American Chemical Society. 123: 11208-18. PMID 11697963 DOI: 10.1021/Ja0166646  0.598
2001 Forbes AJ, Mazur MT, Patel HM, Walsh CT, Kelleher NL. Toward efficient analysis of >70 kDa proteins with 100% sequence coverage. Proteomics. 1: 927-33. PMID 11683509 DOI: 10.1255/Ejms.393  0.797
2001 Walsh CT, Chen H, Keating TA, Hubbard BK, Losey HC, Luo L, Marshall CG, Miller DA, Patel HM. Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines. Current Opinion in Chemical Biology. 5: 525-34. PMID 11578925 DOI: 10.1016/S1367-5931(00)00235-0  0.819
2001 Chen H, Thomas MG, O'Connor SE, Hubbard BK, Burkart MD, Walsh CT. Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics. Biochemistry. 40: 11651-9. PMID 11570865 DOI: 10.1021/Bi0115434  0.708
2001 Yuan W, Jia Y, Tian J, Snell KD, Müh U, Sinskey AJ, Lambalot RH, Walsh CT, Stubbe J. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. Archives of Biochemistry and Biophysics. 394: 87-98. PMID 11566031 DOI: 10.1006/Abbi.2001.2522  0.812
2001 Chen H, O'Connor S, Cane DE, Walsh CT. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chemistry & Biology. 8: 899-912. PMID 11564558 DOI: 10.1016/S1074-5521(01)00064-3  0.722
2001 Marshall CG, Burkart MD, Keating TA, Walsh CT. Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate. Biochemistry. 40: 10655-63. PMID 11524010 DOI: 10.1021/Bi010937S  0.64
2001 Miller DA, Walsh CT, Luo L. C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase. Journal of the American Chemical Society. 123: 8434-5. PMID 11516308 DOI: 10.1021/Ja016398W  0.553
2001 Mulichak AM, Losey HC, Walsh CT, Garavito RM. Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. Structure (London, England : 1993). 9: 547-57. PMID 11470430 DOI: 10.1016/S0969-2126(01)00616-5  0.78
2001 Patel HM, Walsh CT. In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities. Biochemistry. 40: 9023-31. PMID 11467965 DOI: 10.1021/Bi010519N  0.632
2001 Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C. Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 98: 8548-53. PMID 11447274 DOI: 10.1073/Pnas.151246498  0.407
2001 Zamble DB, Miller DA, Heddle JG, Maxwell A, Walsh CT, Hollfelder F. In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites. Proceedings of the National Academy of Sciences of the United States of America. 98: 7712-7. PMID 11427730 DOI: 10.1073/Pnas.141225698  0.775
2001 Kohli RM, Trauger JW, Schwarzer D, Marahiel MA, Walsh CT. Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases. Biochemistry. 40: 7099-108. PMID 11401555 DOI: 10.1021/Bi010036J  0.745
2001 Trauger JW, Kohli RM, Walsh CT. Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase. Biochemistry. 40: 7092-8. PMID 11401554 DOI: 10.1021/Bi010035R  0.686
2001 Admiraal SJ, Walsh CT, Khosla C. The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates. Biochemistry. 40: 6116-23. PMID 11352749 DOI: 10.1021/Bi010080Z  0.319
2001 Luo L, Walsh CT. Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase. Biochemistry. 40: 5329-37. PMID 11330995 DOI: 10.1021/Bi015518+  0.367
2001 Chen H, Walsh CT. Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI. Chemistry & Biology. 8: 301-12. PMID 11325587 DOI: 10.1016/S1074-5521(01)00009-6  0.36
2001 Miller DA, Walsh CT. Yersiniabactin synthetase: probing the recognition of carrier protein domains by the catalytic heterocyclization domains, Cy1 and Cy2, in the chain-initiating HWMP2 subunit. Biochemistry. 40: 5313-21. PMID 11318656 DOI: 10.1021/Bi002905V  0.584
2001 Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry. 40: 4745-55. PMID 11294642 DOI: 10.1021/Bi010050W  0.789
2001 Heddle JG, Blance SJ, Zamble DB, Hollfelder F, Miller DA, Wentzell LM, Walsh CT, Maxwell A. The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. Journal of Molecular Biology. 307: 1223-34. PMID 11292337 DOI: 10.1006/Jmbi.2001.4562  0.762
2001 Reimmann C, Patel HM, Serino L, Barone M, Walsh CT, Haas D. Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa. Journal of Bacteriology. 183: 813-20. PMID 11208777 DOI: 10.1128/Jb.183.3.813-820.2001  0.586
2001 Suo Z, Tseng CC, Walsh CT. Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. Proceedings of the National Academy of Sciences of the United States of America. 98: 99-104. PMID 11134531 DOI: 10.1073/Pnas.98.1.99  0.689
2000 Hubbard BK, Thomas MG, Walsh CT. Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. Chemistry & Biology. 7: 931-42. PMID 11137816 DOI: 10.1016/S1074-5521(00)00043-0  0.388
2000 Zamble DB, McClure CP, Penner-Hahn JE, Walsh CT. The McbB component of microcin B17 synthetase is a zinc metalloprotein. Biochemistry. 39: 16190-9. PMID 11123948 DOI: 10.1021/Bi001398E  0.66
2000 Keating TA, Marshall CG, Walsh CT. Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH. Biochemistry. 39: 15522-30. PMID 11112538 DOI: 10.1021/Bi0016523  0.434
2000 Keating TA, Marshall CG, Walsh CT. Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains. Biochemistry. 39: 15513-21. PMID 11112537 DOI: 10.1021/Bi001651A  0.439
2000 Suo Z, Chen H, Walsh CT. Acyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editing. Proceedings of the National Academy of Sciences of the United States of America. 97: 14188-93. PMID 11106385 DOI: 10.1073/Pnas.260495697  0.619
2000 Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 97: 11942-7. PMID 11035791 DOI: 10.1073/Pnas.210395097  0.816
2000 Ehmann DE, Trauger JW, Stachelhaus T, Walsh CT. Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases. Chemistry & Biology. 7: 765-72. PMID 11033080 DOI: 10.1016/S1074-5521(00)00022-3  0.731
2000 Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT. Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase. Nature. 407: 215-8. PMID 11001063 DOI: 10.1038/35025116  0.741
2000 Healy VL, Mullins LS, Li X, Hall SE, Raushel FM, Walsh CT. D-Ala-D-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studies. Chemistry & Biology. 7: 505-14. PMID 10903933 DOI: 10.1016/S1074-5521(00)00135-6  0.781
2000 Kuzin AP, Sun T, Jorczak-Baillass J, Healy VL, Walsh CT, Knox JR. Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides. Structure (London, England : 1993). 8: 463-70. PMID 10801495 DOI: 10.1016/S0969-2126(00)00129-5  0.79
2000 Healy VL, Lessard IAD, Roper DI, Knox JR, Walsh CT. Vancomycin resistance in enterococci: Reprogramming of the D-Ala-D-Ala ligases in bacterial peptidoglycan biosynthesis Chemistry and Biology. 7: R109-R119. PMID 10801476 DOI: 10.1016/S1074-5521(00)00116-2  0.789
2000 Stachelhaus T, Walsh CT. Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase. Biochemistry. 39: 5775-87. PMID 10801328 DOI: 10.1021/Bi9929002  0.357
2000 Keating TA, Miller DA, Walsh CT. Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase. Biochemistry. 39: 4729-39. PMID 10769129 DOI: 10.1021/Bi992923G  0.619
2000 Trauger JW, Walsh CT. Heterologous expression in Escherichia coli of the first module of the nonribosomal peptide synthetase for chloroeremomycin, a vancomycin-type glycopeptide antibiotic. Proceedings of the National Academy of Sciences of the United States of America. 97: 3112-7. PMID 10716695 DOI: 10.1073/Pnas.97.7.3112  0.443
2000 Keating TA, Suo Z, Ehmann DE, Walsh CT. Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain. Biochemistry. 39: 2297-306. PMID 10694396 DOI: 10.1021/Bi992341Z  0.768
2000 Ehmann DE, Shaw-Reid CA, Losey HC, Walsh CT. The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates. Proceedings of the National Academy of Sciences of the United States of America. 97: 2509-14. PMID 10688898 DOI: 10.1073/Pnas.040572897  0.808
2000 Flugel RS, Hwangbo Y, Lambalot RH, Cronan JE, Walsh CT. Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. The Journal of Biological Chemistry. 275: 959-68. PMID 10625633 DOI: 10.1074/Jbc.275.2.959  0.795
2000 Roy RS, Allen O, Walsh CT. Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17. Chemistry & Biology. 6: 789-99. PMID 10574779 DOI: 10.1016/S1074-5521(99)80126-4  0.375
1999 Cane DE, Walsh CT. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chemistry & Biology. 6: R319-25. PMID 10631508 DOI: 10.1016/S1074-5521(00)80001-0  0.561
1999 Suo Z, Walsh CT, Miller DA. Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments Biochemistry. 38: 17000. PMID 10606536  0.623
1999 Kelleher NL, Hendrickson CL, Walsh CT. Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality. Biochemistry. 38: 15623-30. PMID 10569947 DOI: 10.1021/Bi9913698  0.653
1999 Quadri LE, Keating TA, Patel HM, Walsh CT. Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF. Biochemistry. 38: 14941-54. PMID 10555976 DOI: 10.1021/Bi991787C  0.665
1999 Suo Z, Walsh CT, Miller DA. Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments. Biochemistry. 38: 14023-35. PMID 10529249 DOI: 10.1021/Bi991574N  0.706
1999 Lessard IAD, Healy VL, Park IS, Walsh CT. Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci Biochemistry. 38: 14006-14022. PMID 10529248 DOI: 10.1021/Bi991384C  0.78
1999 Kelleher NL, Zubarev RA, Bush K, Furie B, Furie BC, McLafferty FW, Walsh CT. Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid. Analytical Chemistry. 71: 4250-3. PMID 10517147 DOI: 10.1021/Ac990684X  0.672
1999 Keating TA, Walsh CT. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis. Current Opinion in Chemical Biology. 3: 598-606. PMID 10508662 DOI: 10.1016/S1367-5931(99)00015-0  0.434
1999 Shaw-Reid CA, Kelleher NL, Losey HC, Gehring AM, Berg C, Walsh CT. Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization. Chemistry & Biology. 6: 385-400. PMID 10375542 DOI: 10.1016/S1074-5521(99)80050-7  0.831
1999 Roy RS, Gehring AM, Milne JC, Belshaw PJ, Walsh CT. Thiazole and oxazole peptides: biosynthesis and molecular machinery. Natural Product Reports. 16: 249-63. PMID 10331285 DOI: 10.1039/A806930A  0.692
1999 Sinha Roy R, Kelleher NL, Milne JC, Walsh CT. In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites. Chemistry & Biology. 6: 305-18. PMID 10322125 DOI: 10.1016/S1074-5521(99)80076-3  0.644
1999 Ehmann DE, Gehring AM, Walsh CT. Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. Biochemistry. 38: 6171-7. PMID 10320345 DOI: 10.1021/Bi9829940  0.735
1999 Belshaw PJ, Walsh CT, Stachelhaus T. Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis. Science (New York, N.Y.). 284: 486-9. PMID 10205056 DOI: 10.1126/Science.284.5413.486  0.738
1999 Milne JC, Roy RS, Eliot AC, Kelleher NL, Wokhlu A, Nickels B, Walsh CT. Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17. Biochemistry. 38: 4768-81. PMID 10200165 DOI: 10.1021/Bi982975Q  0.664
1999 Shaw-Reid CA, Kelleher NL, Losey HC, Gehring AM, Berg C, Walsh CT. Erratum: Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization (Chemistry and Biology (1999) 6 (385-400)) Chemistry & Biology. 6. DOI: 10.1016/S1074-5521(00)80026-5  0.804
1998 Quadri LEN, Sello J, Keating TA, Weinreb PH, Walsh CT. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin Chemistry and Biology. 5: 631-645. PMID 9831524 DOI: 10.1016/S1074-5521(98)90291-5  0.707
1998 Cane DE, Walsh CT, Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science (New York, N.Y.). 282: 63-8. PMID 9756477 DOI: 10.1126/Science.282.5386.63  0.57
1998 Lessard IA, Pratt SD, McCafferty DG, Bussiere DE, Hutchins C, Wanner BL, Katz L, Walsh CT. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. Chemistry & Biology. 5: 489-504. PMID 9751644 DOI: 10.1016/S1074-5521(98)90005-9  0.648
1998 Milne JC, Eliot AC, Kelleher NL, Walsh CT. ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. Biochemistry. 37: 13250-61. PMID 9748332 DOI: 10.1021/Bi980996E  0.685
1998 Gehring AM, Mori I, Perry RD, Walsh CT. The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. Biochemistry. 37: 11637-50. PMID 9709002 DOI: 10.1021/Bi9812571  0.445
1998 Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH. Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata. The Journal of Biological Chemistry. 273: 19383-90. PMID 9677355 DOI: 10.1074/Jbc.273.31.19383  0.534
1998 Belshaw PJ, Roy RS, Kelleher NL, Walsh CT. Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase. Chemistry & Biology. 5: 373-84. PMID 9662507 DOI: 10.1016/S1074-5521(98)90071-0  0.82
1998 Ritsema T, Gehring AM, Stuitje AR, van der Drift KM, Dandal I, Lambalot RH, Walsh CT, Thomas-Oates JE, Lugtenberg BJ, Spaink HP. Functional analysis of an interspecies chimera of acyl carrier proteins indicates a specialized domain for protein recognition. Molecular & General Genetics : Mgg. 257: 641-8. PMID 9604887 DOI: 10.1007/S004380050692  0.821
1998 Roy RS, Kim S, Baleja JD, Walsh CT. Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26. Chemistry & Biology. 5: 217-28. PMID 9545435 DOI: 10.1016/S1074-5521(98)90635-4  0.391
1998 Healy VL, Park IS, Walsh CT. Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases. Chemistry & Biology. 5: 197-207. PMID 9545431 DOI: 10.1016/S1074-5521(98)90633-0  0.787
1998 Sinha Roy R, Belshaw PJ, Walsh CT. Mutational analysis of posttranslational heterocycle biosynthesis in the gyrase inhibitor microcin B17: distance dependence from propeptide and tolerance for substitution in a GSCG cyclizable sequence. Biochemistry. 37: 4125-36. PMID 9521734 DOI: 10.1021/Bi9728250  0.753
1998 Gehring AM, Mori I, Walsh CT. Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF. Biochemistry. 37: 2648-59. PMID 9485415 DOI: 10.1021/Bi9726584  0.417
1998 Skarzynski T, Kim DH, Lees WJ, Walsh CT, Duncan K. Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA. Biochemistry. 37: 2572-7. PMID 9485407 DOI: 10.1021/Bi9722608  0.749
1998 Quadri LEN, Weinreb PH, Lei M, Nakano MM, Zuber P, Walsh CT. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carder protein domains in peptide synthetases Biochemistry. 37: 1585-1595. PMID 9484229 DOI: 10.1021/Bi9719861  0.457
1998 Weinreb PH, Quadri LEN, Walsh CT, Zuber P. Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase Biochemistry. 37: 1575-1584. PMID 9484228 DOI: 10.1021/Bi9719859  0.421
1998 Kelleher NL, Belshaw PJ, Walsh CT. Regioselectivity and Chemoselectivity Analysis of Oxazole and Thiazole Ring Formation by the Peptide-Heterocyclizing Microcin B17 Synthetase Using High-Resolution MS/MS Journal of the American Chemical Society. 120: 9716-9717. DOI: 10.1021/Ja9822097  0.756
1997 Walsh CT, Gehring AM, Weinreb PH, Quadri LE, Flugel RS. Post-translational modification of polyketide and nonribosomal peptide synthases. Current Opinion in Chemical Biology. 1: 309-15. PMID 9667867 DOI: 10.1016/S1367-5931(97)80067-1  0.815
1997 Lin CH, Kwon DS, Bollinger JM, Walsh CT. Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli. Biochemistry. 36: 14930-8. PMID 9398217 DOI: 10.1021/bi9714464  0.596
1997 Lin CH, Chen S, Kwon DS, Coward JK, Walsh CT. Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase. Chemistry & Biology. 4: 859-66. PMID 9384533 DOI: 10.1016/S1074-5521(97)90118-6  0.384
1997 Chen S, Lin CH, Kwon DS, Walsh CT, Coward JK. Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli. Journal of Medicinal Chemistry. 40: 3842-50. PMID 9371250 DOI: 10.1021/Jm970414B  0.347
1997 Carreras CW, Gehring AM, Walsh CT, Khosla C. Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry. 36: 11757-61. PMID 9305965 DOI: 10.1021/Bi971350+  0.419
1997 McCafferty DG, Lessard IA, Walsh CT. Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. Biochemistry. 36: 10498-505. PMID 9265630 DOI: 10.1021/Bi970543U  0.684
1997 Sugiura I, Furie B, Walsh CT, Furie BC. Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state. Proceedings of the National Academy of Sciences of the United States of America. 94: 9069-74. PMID 9256436 DOI: 10.1073/Pnas.94.17.9069  0.348
1997 Gehring AM, Bradley KA, Walsh CT. Enterobactin biosynthesis in escherichia coli: Isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by ente using ATP and 2,3-dihydroxybenzoate Biochemistry. 36: 8495-8503. PMID 9214294 DOI: 10.1021/Bi970453P  0.409
1997 Lambalot RH, Walsh CT. Holo-[acyl-carrier-protein] synthase of Escherichia coli. Methods in Enzymology. 279: 254-62. PMID 9211277 DOI: 10.1016/S0076-6879(97)79029-3  0.81
1997 Li S, Furie BC, Furie B, Walsh CT. The propeptide of the vitamin K-dependent carboxylase substrate accelerates formation of the gamma-glutamyl carbanion intermediate. Biochemistry. 36: 6384-90. PMID 9174354 DOI: 10.1021/Bi962816B  0.358
1997 Gehring AM, Lambalot RH, Vogel KW, Drueckhammer DG, Walsh CT. Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase. Chemistry & Biology. 4: 17-24. PMID 9070424 DOI: 10.1016/S1074-5521(97)90233-7  0.822
1997 Wang J, Walsh CT. Mechanistic studies on full length and the catalytic domain of the tandem SH2 domain-containing protein tyrosine phosphatase: analysis of phosphoenzyme levels and Vmax stimulatory effects of glycerol and of a phosphotyrosyl peptide ligand. Biochemistry. 36: 2993-9. PMID 9062130 DOI: 10.1021/Bi9611873  0.393
1997 Fan C, Park IS, Walsh CT, Knox JR. D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant. Biochemistry. 36: 2531-8. PMID 9054558 DOI: 10.1021/Bi962431T  0.313
1997 Grace MR, Walsh CT, Cole PA. Divalent ion effects and insights into the catalytic mechanism of protein tyrosine kinase Csk. Biochemistry. 36: 1874-81. PMID 9048573 DOI: 10.1021/Bi962138T  0.508
1997 Benson TE, Walsh CT, Hogle JM. X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution. Biochemistry. 36: 806-11. PMID 9020778 DOI: 10.1021/Bi962221G  0.344
1997 Benson TE, Walsh CT, Massey V. Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acid. Biochemistry. 36: 796-805. PMID 9020777 DOI: 10.1021/Bi962220O  0.407
1997 Madison LL, Vivas EI, Li YM, Walsh CT, Kolter R. The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17 Molecular Microbiology. 23: 161-168. PMID 9004229 DOI: 10.1046/J.1365-2958.1997.2041565.X  0.415
1997 Sagoo JK, Fruman DA, Wesselborg S, Walsh CT, Bierer BE. Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain. The Biochemical Journal. 879-84. PMID 9003375 DOI: 10.1042/Bj3200879  0.39
1997 Kwon DS, Lin CH, Chen S, Coward JK, Walsh CT, Bollinger JM. Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains. The Journal of Biological Chemistry. 272: 2429-36. PMID 8999955 DOI: 10.1074/jbc.272.4.2429  0.592
1997 Haldimann A, Prahalad MK, Fisher SL, Kim SK, Walsh CT, Wanner BL. Altered recognition mutants of the response regulator PhoB: a new genetic strategy for studying protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 93: 14361-6. PMID 8962056 DOI: 10.1073/Pnas.93.25.14361  0.329
1997 Chen S, Lin CH, Walsh CT, Coward JK. Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase Bioorganic and Medicinal Chemistry Letters. 7: 505-510. DOI: 10.1016/S0960-894X(97)00061-9  0.316
1996 Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. A new enzyme superfamily - the phosphopantetheinyl transferases. Chemistry & Biology. 3: 923-36. PMID 8939709 DOI: 10.1016/S1074-5521(96)90181-7  0.818
1996 Li YM, Milne JC, Madison LL, Kolter R, Walsh CT. From peptide precursors to oxazole and thiazole-containing peptide antibiotics: Microcin B17 synthase Science. 274: 1188-1193. PMID 8895467 DOI: 10.1126/Science.274.5290.1188  0.4
1996 Walsh CT, Benson TE, Kim DH, Lees WJ. The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis. Chemistry & Biology. 3: 83-91. PMID 8807832 DOI: 10.1016/S1074-5521(96)90282-3  0.731
1996 Benson TE, Walsh CT, Hogle JM. The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls. Structure (London, England : 1993). 4: 47-54. PMID 8805513 DOI: 10.1016/S0969-2126(96)00008-1  0.394
1996 Kharbanda S, Bharti A, Pei D, Wang J, Pandey P, Ren R, Weichselbaum R, Walsh CT, Kufe D. The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1. Proceedings of the National Academy of Sciences of the United States of America. 93: 6898-901. PMID 8692915 DOI: 10.1073/Pnas.93.14.6898  0.603
1996 Kim DH, Lees WJ, Kempsell KE, Lane WS, Duncan K, Walsh CT. Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin. Biochemistry. 35: 4923-8. PMID 8664284 DOI: 10.1021/Bi952937W  0.739
1996 Fisher SL, Kim SK, Wanner BL, Walsh CT. Kinetic comparison of the specificity of the vancomycin resistance VanSfor two response regulators, VanR and PhoB. Biochemistry. 35: 4732-40. PMID 8664263 DOI: 10.1021/Bi9525435  0.355
1996 Sugiura I, Furie B, Walsh CT, Furie BC. Profactor IX propeptide and glutamate substrate binding sites on the vitamin K-dependent carboxylase identified by site-directed mutagenesis. Journal of Biological Chemistry. 271: 17837-17844. PMID 8663364 DOI: 10.1074/Jbc.271.30.17837  0.337
1996 Lees WJ, Benson TE, Hogle JM, Walsh CT. (E)-enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Biochemistry. 35: 1342-51. PMID 8634262 DOI: 10.1021/Bi952287W  0.657
1996 Kim DH, Tucker-Kellogg GW, Lees WJ, Walsh CT. Analysis of fluoromethyl group chirality establishes a common stereochemical course for the enolpyruvyl transfers catalyzed by EPSP synthase and UDP-GlcNAc enolpyruvyl transferase. Biochemistry. 35: 5435-40. PMID 8611533 DOI: 10.1021/Bi952978S  0.741
1996 Pei D, Wang J, Walsh CT. Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. Proceedings of the National Academy of Sciences of the United States of America. 93: 1141-5. PMID 8577729 DOI: 10.1073/Pnas.93.3.1141  0.632
1996 Gehring AM, Lees WJ, Mindiola DJ, Walsh CT, Brown ED. Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli. Biochemistry. 35: 579-85. PMID 8555230 DOI: 10.1021/Bi952275A  0.688
1996 Wu Z, Walsh CT. Phosphinate analogs of D-, D-dipeptides: slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium. Proceedings of the National Academy of Sciences of the United States of America. 92: 11603-7. PMID 8524812 DOI: 10.1073/Pnas.92.25.11603  0.326
1996 Walsh C, Fisher S, Park I, Prahalad M, Wu Z. Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story Chemistry & Biology. 3: 21-28. DOI: 10.1016/S1074-5521(96)90079-4  0.305
1995 Park I, Chung J, Walsh CT, Yun Y, Strominger JL, Shin J. Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region Proceedings of the National Academy of Sciences of the United States of America. 92: 12338-12342. PMID 8618896 DOI: 10.1073/Pnas.92.26.12338  0.473
1995 Shi Y, Walsh CT. Active site mapping of Escherichia coli D-Ala-D-Ala ligase by structure-based mutagenesis. Biochemistry. 34: 2768-76. PMID 7893688 DOI: 10.1021/Bi00009A005  0.314
1995 Wu Z, Wright GD, Walsh CT. Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry. 34: 2455-63. PMID 7873524 DOI: 10.1021/Bi00008A008  0.617
1995 Fan C, Moews PC, Shi Y, Walsh CT, Knox JR. A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 92: 1172-6. PMID 7862655 DOI: 10.1073/Pnas.92.4.1172  0.451
1995 Yamada M, Kuliopulos A, Nelson NP, Roth DA, Furie B, Furie BC, Walsh CT. Localization of the factor IX propeptide binding site on recombinant vitamin K dependent carboxylase using benzoylphenylalanine photoaffinity peptide inactivators. Biochemistry. 34: 481-9. PMID 7819240 DOI: 10.1021/Bi00002A012  0.346
1995 Bollinger JM, Kwon DS, Huisman GW, Kolter R, Walsh CT. Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase. The Journal of Biological Chemistry. 270: 14031-41. PMID 7775463 DOI: 10.1074/Jbc.270.23.14031  0.651
1995 Cole PA, Grace MR, Phillips RS, Burn P, Walsh CT. The role of the catalytic base in the protein tyrosine kinase Csk. The Journal of Biological Chemistry. 270: 22105-8. PMID 7673185 DOI: 10.1074/Jbc.270.38.22105  0.518
1995 Hidalgo E, Bollinger JM, Bradley TM, Walsh CT, Demple B. Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription. The Journal of Biological Chemistry. 270: 20908-14. PMID 7673113 DOI: 10.1074/Jbc.270.36.20908  0.553
1995 Brown ED, Vivas EI, Walsh CT, Kolter R. MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli Journal of Bacteriology. 177: 4194-4197. PMID 7608103 DOI: 10.1128/Jb.177.14.4194-4197.1995  0.363
1995 Joung I, Kim T, Stolz LA, Payne G, Winkler DG, Walsh CT, Strominger JL, Shin J. Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain Proceedings of the National Academy of Sciences of the United States of America. 92: 5778-5782. PMID 7597029 DOI: 10.1073/Pnas.92.13.5778  0.474
1995 Lambalot RH, Walsh CT. Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. The Journal of Biological Chemistry. 270: 24658-61. PMID 7559576 DOI: 10.1074/Jbc.270.42.24658  0.813
1995 Fisher SL, Jiang W, Wanner BL, Walsh CT. Cross-talk between the histidine protein kinase VanS and the response regulator PhoB. Characterization and identification of a VanS domain that inhibits activation of PhoB. The Journal of Biological Chemistry. 270: 23143-9. PMID 7559459 DOI: 10.1074/Jbc.270.39.23143  0.387
1995 Benson TE, Filman DJ, Walsh CT, Hogle JM. An enzyme-substrate complex involved in bacterial cell wall biosynthesis. Nature Structural Biology. 2: 644-53. PMID 7552726 DOI: 10.1038/Nsb0895-644  0.385
1995 Pluskey S, Wandless TJ, Walsh CT, Shoelson SE. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. The Journal of Biological Chemistry. 270: 2897-900. PMID 7531695 DOI: 10.1074/Jbc.270.7.2897  0.377
1995 Lees WJ, Walsh CT. Analysis of the Enol Ether Transfer Catalyzed by UDP-GlcNAc Enolpyruvyl Transferase Using (E)- and (Z)-Isomers of Phosphoenolbutyrate: Stereochemical, Partitioning, and Isotope Effect Studies Journal of the American Chemical Society. 117: 7329-7337. DOI: 10.1021/Ja00133A006  0.633
1995 Kim DH, Lees WJ, Walsh CT. Stereochemical analysis of the tetrahedral adduct formed at the active site of UDP-GlcNAc enolpyruvyl transferase from the pseudosubstrates, (E)- and (Z)-3-fluorophosphoenolpyruvate, in D2O Journal of the American Chemical Society. 117: 6380-6381. DOI: 10.1021/Ja00128A037  0.725
1995 Kim DH, Lees WJ, Haley TM, Walsh CT. Kinetic characterization of the inactivation of UDP-GlcNAc enolpyruvyl transferase by (Z)-3-fluorophosphoenolpyruvate: Evidence for two oxocarbenium ion intermediates in enolpyruvyl transfer catalysis Journal of the American Chemical Society. 117: 1494-1502. DOI: 10.1021/Ja00110A005  0.71
1994 Payne G, Stolz LA, Pei D, Band H, Shoelson SE, Walsh CT. The phosphopeptide-binding specificity of Src family SH2 domains. Chemistry & Biology. 1: 99-105. PMID 9383377 DOI: 10.1016/1074-5521(94)90047-7  0.641
1994 Fejzo J, Etzkorn FA, Clubb RT, Shi Y, Walsh CT, Wagner G. The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin. Biochemistry. 33: 5711-20. PMID 8180197 DOI: 10.1021/Bi00185A007  0.671
1994 Comess KM, Shewchuk LM, Ivanetich K, Walsh CT. Construction of a synthetic gene for the metalloregulatory protein MerR and analysis of regionally mutated proteins for transcriptional regulation. Biochemistry. 33: 4175-86. PMID 8155633 DOI: 10.1021/Bi00180A010  0.319
1994 Shi Y, Brown ED, Walsh CT. Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions. Proceedings of the National Academy of Sciences of the United States of America. 91: 2767-71. PMID 8146188 DOI: 10.1073/Pnas.91.7.2767  0.339
1994 Clubb RT, Ferguson SB, Walsh CT, Wagner G. Three-dimensional solution structure of Escherichia coli periplasmic cyclophilin. Biochemistry. 33: 2761-72. PMID 8130188 DOI: 10.1021/Bi00176A004  0.339
1994 Nadeau K, Nadler SG, Saulnier M, Tepper MA, Walsh CT. Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. Biochemistry. 33: 2561-7. PMID 8117717  0.389
1994 Etzkorn FA, Chang ZY, Stolz LA, Walsh CT. Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin.cyclosporin A complex. Biochemistry. 33: 2380-8. PMID 8117697 DOI: 10.1021/Bi00175A005  0.697
1994 Lorenz U, Ravichandran KS, Pei D, Walsh CT, Burakoff SJ, Neel BG. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. Molecular and Cellular Biology. 14: 1824-34. PMID 8114715 DOI: 10.1128/mcb.14.3.1824-1834.1994  0.538
1994 Nadler SG, Cleaveland J, Tepper MA, Walsh C, Nadeau K. Studies on the interaction of the immunosuppressant 15-deoxyspergualin with heat shock proteins. Annals of the New York Academy of Sciences. 696: 412-4. PMID 8109853 DOI: 10.1111/J.1749-6632.1993.Tb17181.X  0.42
1994 Olson CL, Nadeau KC, Sullivan MA, Winquist AG, Donelson JE, Walsh CT, Engman DM. Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruzi Journal of Biological Chemistry. 269: 3868-3874. PMID 8106432  0.393
1994 Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure (London, England : 1993). 2: 33-44. PMID 8075981 DOI: 10.1016/S0969-2126(00)00006-X  0.798
1994 Marquardt JL, Brown ED, Lane WS, Haley TM, Ichikawa Y, Wong CH, Walsh CT. Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin. Biochemistry. 33: 10646-51. PMID 8075065 DOI: 10.1021/Bi00201A011  0.536
1994 Chu YH, Lees WJ, Stassinopoulos A, Walsh CT. Using affinity capillary electrophoresis to determine binding stoichiometries of protein-ligand interactions. Biochemistry. 33: 10616-21. PMID 8075061 DOI: 10.1021/Bi00201A007  0.682
1994 Fan C, Moews PC, Walsh CT, Knox JR. Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. Science (New York, N.Y.). 266: 439-43. PMID 7939684 DOI: 10.1126/Science.7939684  0.312
1994 Benson TE, Walsh CT, Hogle JM. Crystallization and preliminary X-ray crystallographic studies of UDP-N-acetylenolpyruvylglucosamine reductase. Protein Science : a Publication of the Protein Society. 3: 1125-7. PMID 7920261 DOI: 10.1002/Pro.5560030718  0.311
1994 Pei D, Lorenz U, Klingmüller U, Neel BG, Walsh CT. Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains. Biochemistry. 33: 15483-93. PMID 7528537 DOI: 10.1021/Bi00255A030  0.659
1994 Cole PA, Burn P, Takacs B, Walsh CT. Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects Journal of Biological Chemistry. 269: 30880-30887. PMID 7527038  0.442
1994 Kim DH, Lees WJ, Walsh CT. Formation of two enzyme-bound reaction intermediate analogs during inactivation of UDP-GlcNAc enolpyruvyl transferase by (E)- or (Z)-3-fluorophosphoenolpyruvate Journal of the American Chemical Society. 116: 6478-6479. DOI: 10.1021/Ja00093A076  0.745
1994 Kuliopulos A, Walsh CT. Production, Purification, and Cleavage of Tandem Repeats of Recombinant Peptides Journal of the American Chemical Society. 116: 4599-4607. DOI: 10.1021/Ja00090A008  0.338
1993 Clubb RT, Thanabal V, Fejzo J, Ferguson SB, Zydowsky L, Baker CH, Walsh CT, Wagner G. Secondary structure and backbone resonance assignments of the periplasmic cyclophilin type peptidyl-prolyl isomerase from Escherichia coli. Biochemistry. 32: 6391-401. PMID 8518284 DOI: 10.1021/Bi00076A012  0.358
1993 Winkler DG, Park I, Kim T, Payne NS, Walsh CT, Strominger JL, Shin J. Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck. Proceedings of the National Academy of Sciences of the United States of America. 90: 5176-80. PMID 8506364 DOI: 10.1073/Pnas.90.11.5176  0.424
1993 Rehemtulla A, Roth DA, Wasley LC, Kuliopulos A, Walsh CT, Furie B, Furie BC, Kaufman RJ. In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 4611-5. PMID 8506307 DOI: 10.1073/Pnas.90.10.4611  0.334
1993 Wright GD, Holman TR, Walsh CT. Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry. 32: 5057-63. PMID 8494882 DOI: 10.1021/Bi00070A013  0.653
1993 Benson TE, Marquardt JL, Marquardt AC, Etzkorn FA, Walsh CT. Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase. Biochemistry. 32: 2024-30. PMID 8448160 DOI: 10.1021/Bi00059A019  0.7
1993 Pei D, Neel BG, Walsh CT. Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 90: 1092-6. PMID 8430079 DOI: 10.1073/Pnas.90.3.1092  0.679
1993 Nadeau K, Das A, Walsh CT. Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases. The Journal of Biological Chemistry. 268: 1479-87. PMID 8419347  0.39
1993 Rennex D, Cummings RT, Pickett M, Walsh CT, Bradley M. Role of tyrosine residues in Hg(II) detoxification by mercuric reductase from Bacillus sp. strain RC607. Biochemistry. 32: 7475-8. PMID 8338845 DOI: 10.1021/Bi00080A019  0.341
1993 Cho H, Krishnaraj R, Itoh M, Kitas E, Bannwarth W, Saito H, Walsh CT. Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTP beta, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors. Protein Science : a Publication of the Protein Society. 2: 977-84. PMID 8318901 DOI: 10.1002/Pro.5560020611  0.39
1993 Wright GD, Walsh CT. Identification of a common protease-sensitive region in D-alanyl-D-alanine and D-alanyl-D-lactate ligases and photoaffinity labeling with 8-azido ATP. Protein Science : a Publication of the Protein Society. 2: 1765-9. PMID 8251948 DOI: 10.1002/Pro.5560021020  0.598
1993 Roux B, Walsh CT. p-Aminobenzoate synthesis in Escherichia coli: mutational analysis of three conserved amino acid residues of the amidotransferase PabA. Biochemistry. 32: 3763-8. PMID 8096767 DOI: 10.1021/Bi00065A031  0.397
1993 Payne G, Shoelson SE, Gish GD, Pawson T, Walsh CT. Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proceedings of the National Academy of Sciences of the United States of America. 90: 4902-6. PMID 7685110 DOI: 10.1073/Pnas.90.11.4902  0.333
1993 Reichert J, Sakaitani M, Walsh CT. Characterization of EntF as a serine-activating enzyme. Protein Science : a Publication of the Protein Society. 1: 549-56. PMID 1338974 DOI: 10.1002/Pro.5560010410  0.398
1993 Zydowsky LD, Ho SI, Baker CH, McIntyre K, Walsh CT. Overexpression, purification, and characterization of yeast cyclophilins A and B. Protein Science : a Publication of the Protein Society. 1: 961-9. PMID 1304384 DOI: 10.1002/Pro.5560010801  0.306
1993 Smith K, Nadeau K, Bradley M, Walsh C, Fairlamb AH. Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata. Protein Science : a Publication of the Protein Society. 1: 874-83. PMID 1304372 DOI: 10.1002/Pro.5560010705  0.532
1993 Lee JP, Cho H, Bannwarth W, Kitas EA, Walsh CT. NMR analysis of regioselectivity in dephosphorylation of a triphosphotyrosyl dodecapeptide autophosphorylation site of the insulin receptor by a catalytic fragment of LAR phosphotyrosine phosphatase. Protein Science : a Publication of the Protein Society. 1: 1353-62. PMID 1303753 DOI: 10.1002/Pro.5560011015  0.353
1993 Marquardt JL, Brown ED, Walsh CT, Anderson KS. Isolation and structural elucidation of a tetrahedral intermediate in the UDP-N-acetylglucosamine enolpyruvoyl transferase enzymic pathway Journal of the American Chemical Society. 115: 10398-10399. DOI: 10.1021/Ja00075A081  0.339
1993 Etzkorn FA, Stolz LA, Chang Z, Walsh CT. Role of the cyclosporin-A-cyclophilin complex, FK506-FK506-binding protein complex and calcineurin in the inhibition of T-cell signal transduction. Current opinion in structural biology 1993, 3:929-933 Current Opinion in Structural Biology. 3: 929-933. DOI: 10.1016/0959-440X(93)90158-H  0.64
1992 Roux B, Walsh CT. p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA. Biochemistry. 31: 6904-10. PMID 1637823 DOI: 10.1021/Bi00145A006  0.397
1992 Leichus BN, Bradley M, Nadeau K, Walsh CT, Blanchard JS. Kinetic isotope effect analysis of the reaction catalyzed by Trypanosoma congolense trypanothione reductase Biochemistry. 31: 6414-6420. PMID 1633154 DOI: 10.1021/Bi00143A008  0.477
1992 Moore MJ, Miller SM, Walsh CT. C-terminal cysteines of Tn501 mercuric ion reductase. Biochemistry. 31: 1677-85. PMID 1531297 DOI: 10.1021/Bi00121A015  0.585
1992 Marquardt JL, Siegele DA, Kolter R, Walsh CT. Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase Journal of Bacteriology. 174: 5748-5752. PMID 1512209 DOI: 10.1128/Jb.174.17.5748-5752.1992  0.391
1992 Wright GD, Molinas C, Arthur M, Courvalin P, Walsh CT. Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147. Antimicrobial Agents and Chemotherapy. 36: 1514-8. PMID 1510448 DOI: 10.1128/Aac.36.7.1514  0.664
1992 Arthur M, Molinas C, Bugg TD, Wright GD, Walsh CT, Courvalin P. Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrobial Agents and Chemotherapy. 36: 867-9. PMID 1503450 DOI: 10.1128/Aac.36.4.867  0.622
1992 Kuliopulos A, Cieurzo CE, Furie B, Furie BC, Walsh CT. N-bromoacetyl-peptide substrate affinity labeling of vitamin K dependent carboxylaset Biochemistry. 31: 9436-9444. PMID 1390725 DOI: 10.1021/Bi00154A016  0.41
1992 Kaye RE, Fruman DA, Bierer BE, Albers MW, Zydowsky LD, Ho SI, Jin YJ, Castells MC, Schreiber SL, Walsh CT. Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proceedings of the National Academy of Sciences of the United States of America. 89: 8542-6. PMID 1382293 DOI: 10.1073/Pnas.89.18.8542  0.411
1992 Cho H, Ramer SE, Itoh M, Kitas E, Bannwarth W, Burn P, Saito H, Walsh CT. Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: purification and characterization for specificity and mechanism. Biochemistry. 31: 133-8. PMID 1370625 DOI: 10.1021/Bi00116A019  0.413
1992 Walsh C, Bradley M, Nadeau K. Molecular studies on trypanothione reductase: an antiparasitic target enzyme. Current Topics in Cellular Regulation. 33: 409-17. PMID 1354149 DOI: 10.1016/B978-0-12-152833-1.50028-9  0.557
1992 Zydowsky LD, Etzkorn FA, Chang HY, Ferguson SB, Stolz LA, Ho SI, Walsh CT. Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Science : a Publication of the Protein Society. 1: 1092-9. PMID 1338979 DOI: 10.1002/Pro.5560010903  0.685
1992 Nadeau K, Sullivan MA, Bradley M, Engman DM, Walsh CT. 83-Kilodalton heat shock proteins of trypanosomes are potent peptide- stimulated ATPases Protein Science. 1: 970-979. PMID 1304385 DOI: 10.1002/Pro.5560010802  0.499
1992 Cho H, Krishnaraj R, Kitas E, Bannwarth W, Walsh CT, Anderson KS. Isolation and structural elucidation of a novel phosphocysteine intermediate in the LAR protein tyrosine phosphatase enzymic pathway Journal of the American Chemical Society. 114: 7296-7298. DOI: 10.1021/Ja00044A052  0.364
1992 Wright GD, Walsh CT. D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance Accounts of Chemical Research. 25: 468-473. DOI: 10.1021/Ar00022A006  0.597
1991 Ye QZ, Liu J, Walsh CT. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Proceedings of the National Academy of Sciences of the United States of America. 87: 9391-5. PMID 2251281 DOI: 10.1073/Pnas.87.23.9391  0.384
1991 Ramer SE, Winkler DG, Carrera A, Roberts TM, Walsh CT. Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. Proceedings of the National Academy of Sciences of the United States of America. 88: 6254-8. PMID 2068105 DOI: 10.1073/Pnas.88.14.6254  0.359
1991 Schiering N, Kabsch W, Moore MJ, Distefano MD, Walsh CT, Pai EF. Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607. Nature. 352: 168-72. PMID 2067577 DOI: 10.1038/352168A0  0.714
1991 Sullivan FX, Sobolov SB, Bradley M, Walsh CT. Mutational analysis of parasite trypanothione reductase: acquisition of glutathione reductase activity in a triple mutant. Biochemistry. 30: 2761-7. PMID 2007114 DOI: 10.1021/Bi00225A004  0.374
1991 Liu J, Chen CM, Walsh CT. Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue. Biochemistry. 30: 2306-10. PMID 2001362 DOI: 10.1021/Bi00223A003  0.313
1991 Miller SM, Massey V, Williams CH, Ballou DP, Walsh CT. Communication between the active sites in dimeric mercuric ion reductase: an alternating sites hypothesis for catalysis. Biochemistry. 30: 2600-12. PMID 2001350 DOI: 10.1021/Bi00224A006  0.386
1991 Roydon Price E, Zydowsky LD, Jin M, Hunter Baker C, McKeon FD, Walsh CT. Human cyclophilin B: A second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence Proceedings of the National Academy of Sciences of the United States of America. 88: 1903-1907. PMID 2000394 DOI: 10.1073/Pnas.88.5.1903  0.335
1991 Zawadzke LE, Bugg TD, Walsh CT. Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes. Biochemistry. 30: 1673-82. PMID 1993184 DOI: 10.1021/Bi00220A033  0.355
1991 Raybuck SA, Ramer SE, Abbanat DR, Peters JW, Orme-Johnson WH, Ferry JG, Walsh CT. Demonstration of carbon-carbon bond cleavage of acetyl coenzyme A by using isotopic exchange catalyzed by the CO dehydrogenase complex from acetate-grown Methanosarcina thermophila. Journal of Bacteriology. 173: 929-32. PMID 1987173 DOI: 10.1128/Jb.173.2.929-932.1991  0.376
1991 Walsh C, Bradley M, Nadeau K. Molecular studies on trypanothione reductase, a target for antiparasitic drugs. Trends in Biochemical Sciences. 16: 305-9. PMID 1957352 DOI: 10.1016/0968-0004(91)90124-E  0.389
1991 Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry. 30: 10408-15. PMID 1931965 DOI: 10.1021/Bi00107A007  0.642
1991 Li PM, Reichert J, Freyd G, Horvitz HR, Walsh CT. The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain. Proceedings of the National Academy of Sciences of the United States of America. 88: 9210-3. PMID 1924383 DOI: 10.1073/Pnas.88.20.9210  0.32
1991 Rusnak F, Sakaitani M, Drueckhammer D, Reichert J, Walsh CT. Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. Biochemistry. 30: 2916-27. PMID 1826089 DOI: 10.1021/Bi00225A027  0.394
1991 Cho HJ, Ramer SE, Itoh M, Winkler DG, Kitas E, Bannwarth W, Burn P, Saito H, Walsh CT. Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system. Biochemistry. 30: 6210-6. PMID 1711896 DOI: 10.1021/Bi00239A019  0.396
1991 Anderson KS, Kati WM, Ye QZ, Liu J, Walsh CT, Benesi AJ, Johnson KA. Isolation and structure elucidation of the 4-amino-4-deoxychorismate intermediate in the PABA enzymic pathway Journal of the American Chemical Society. 113: 3198-3200. DOI: 10.1021/Ja00008A073  0.535
1990 Galakatos NG, Walsh CT. Mutations at the interdomain hinge region of the DadB alanine racemase: effects of length and conformational constraint of the linker sequence on catalytic efficiency. Biochemistry. 28: 8167-74. PMID 2690935 DOI: 10.1021/Bi00446A031  0.381
1990 Ma H, Bloom LM, Zhu ZM, Walsh CT, Botstein D. Isolation and characterization of mutations in the HXK2 gene of Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 5630-42. PMID 2685571 DOI: 10.1128/Mcb.9.12.5630  0.32
1990 Helmann JD, Ballard BT, Walsh CT. The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metal-bridged dimer. Science (New York, N.Y.). 247: 946-8. PMID 2305262 DOI: 10.1126/Science.2305262  0.549
1990 Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT. Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H. Biochemistry. 29: 7237-44. PMID 2207102 DOI: 10.1021/Bi00483A011  0.359
1990 McDermott AE, Creuzet F, Griffin RG, Zawadzke LE, Ye QZ, Walsh CT. Rotational resonance determination of the structure of an enzyme-inhibitor complex: phosphorylation of an (aminoalkyl)phosphinate inhibitor of D-alanyl-D-alanine ligase by ATP. Biochemistry. 29: 5767-75. PMID 2200515 DOI: 10.1021/Bi00476A018  0.329
1990 Liu J, Walsh CT. Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A. Proceedings of the National Academy of Sciences of the United States of America. 87: 4028-32. PMID 2190212 DOI: 10.1073/Pnas.87.11.4028  0.356
1990 Miller SM, Massey V, Ballou D, Williams CH, Distefano MD, Moore MJ, Walsh CT. Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase. Biochemistry. 29: 2831-41. PMID 2189497 DOI: 10.1021/Bi00463A028  0.712
1990 Distefano MD, Moore MJ, Walsh CT. Active site of mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from the adjacent subunit: evidence from in vivo and in vitro heterodimer formation. Biochemistry. 29: 2703-13. PMID 2189495 DOI: 10.1021/Bi00463A013  0.71
1990 Liu J, Albers MW, Chen CM, Schreiber SL, Walsh CT. Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 87: 2304-8. PMID 2179953 DOI: 10.1073/Pnas.87.6.2304  0.554
1990 Sakaitani M, Rusnak F, Quinn NR, Tu C, Frigo TB, Berchtold GA, Walsh CT. Mechanistic studies on trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Ent A) in the biosynthesis of the iron chelator enterobactin. Biochemistry. 29: 6789-98. PMID 2144454 DOI: 10.1021/Bi00481A006  0.632
1990 Rusnak F, Liu J, Quinn N, Berchtold GA, Walsh CT. Subcloning of the enterobactin biosynthetic gene entB: expression, purification, characterization, and substrate specificity of isochorismatase. Biochemistry. 29: 1425-35. PMID 2139796 DOI: 10.1021/Bi00458A013  0.668
1990 Liu J, Quinn N, Berchtold GA, Walsh CT. Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate. Biochemistry. 29: 1417-25. PMID 2139795 DOI: 10.1021/Bi00458A012  0.665
1990 Mayerl F, Piret J, Kiener A, Walsh CT, Yasui A. Functional expression of 8-hydroxy-5-deazaflavin-dependent DNA photolyase from Anacystis nidulans in Streptomyces coelicolor. Journal of Bacteriology. 172: 6061-5. PMID 2120199 DOI: 10.1128/Jb.172.10.6061-6065.1990  0.325
1990 Albers MW, Walsh CT, Schreiber SL. Substrate specificity for the human rotamase FKBP: a view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics The Journal of Organic Chemistry. 55: 4984-4986. DOI: 10.1021/Jo00304A003  0.459
1990 Raybuck SA, Distefano MD, Teo BK, Orme-Johnson W, Walsh CT. An EXAFS investigation of Hg(II) binding to mercuric reductase: Comparative analysis of the wild-type enzyme and a mutant enzyme generated by site-directed mutagenesis Journal of the American Chemical Society. 112: 1983-1989. DOI: 10.1021/Ja00161A051  0.591
1990 Walsh CT, Liu J, Rusnak F, Sakaitani M. Molecular studies on enzymes in chorismate metabolism and the enterobactin biosynthetic pathway Chemical Reviews. 90: 1105-1129. DOI: 10.1021/Cr00105A003  0.308
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