Edward M. Greenfield - Publications

Affiliations: 
Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Cell Biology, Biomedical Engineering

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Bechtel CP, Gebhart JJ, Tatro JM, Kiss-Toth E, Wilkinson JM, Greenfield EM. Particle-Induced Osteolysis Is Mediated by TIRAP/Mal in Vitro and in Vivo: Dependence on Adherent Pathogen-Associated Molecular Patterns. The Journal of Bone and Joint Surgery. American Volume. 98: 285-94. PMID 26888676 DOI: 10.2106/JBJS.O.00736  0.6
2015 Choe H, Narayanan AS, Gandhi DA, Weinberg A, Marcus RE, Lee Z, Bonomo RA, Greenfield EM. Immunomodulatory Peptide IDR-1018 Decreases Implant Infection and Preserves Osseointegration. Clinical Orthopaedics and Related Research. PMID 25953690 DOI: 10.1007/s11999-015-4301-2  0.6
2015 Bonsignore LA, Goldberg VM, Greenfield EM. Machine oil inhibits the osseointegration of orthopaedic implants by impairing osteoblast attachment and spreading. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 979-87. PMID 25676177 DOI: 10.1002/jor.22850  0.6
2015 Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S. ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 30: 765-74. PMID 25401279 DOI: 10.1002/jbmr.2409  0.6
2015 MacInnes SJ, Del Vescovo E, Kiss-Toth E, Ollier WE, Kay PR, Gordon A, Greenfield EM, Wilkinson MJ. Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 193-8. PMID 25399506 DOI: 10.1002/jor.22755  0.6
2014 Greenfield EM. Do genetic susceptibility, Toll-like receptors, and pathogen-associated molecular patterns modulate the effects of wear? Clinical Orthopaedics and Related Research. 472: 3709-17. PMID 25034980 DOI: 10.1007/s11999-014-3786-4  0.6
2014 Rettew AN, Getty PJ, Greenfield EM. Receptor tyrosine kinases in osteosarcoma: not just the usual suspects. Advances in Experimental Medicine and Biology. 804: 47-66. PMID 24924168 DOI: 10.1007/978-3-319-04843-7_3  0.6
2013 Ouyang Z, Chen Z, Ishikawa M, Yue X, Kawanami A, Leahy P, Greenfield EM, Murakami S. Prx1 and 3.2kb Col1a1 promoters target distinct bone cell populations in transgenic mice. Bone. PMID 24513582 DOI: 10.1016/j.bone.2013.10.016  0.6
2013 Chen X, Hausman BS, Luo G, Zhou G, Murakami S, Rubin J, Greenfield EM. Protein kinase inhibitor γ reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor. Stem Cells (Dayton, Ohio). 31: 2789-99. PMID 23963683 DOI: 10.1002/stem.1524  0.6
2013 Bonsignore LA, Anderson JR, Lee Z, Goldberg VM, Greenfield EM. Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation. Bone. 52: 93-101. PMID 22995462 DOI: 10.1016/j.bone.2012.09.011  0.6
2012 Messerschmitt PJ, Rettew AN, Schroeder NO, Brookover RE, Jakatdar AP, Getty PJ, Greenfield EM. Osteosarcoma Phenotype Is Inhibited by 3,4-Methylenedioxy-β-nitrostyrene. Sarcoma. 2012: 479712. PMID 22701331 DOI: 10.1155/2012/479712  0.6
2012 Greenfield EM. Anabolic effects of intermittent PTH on osteoblasts. Current Molecular Pharmacology. 5: 127-34. PMID 21787293  0.6
2011 Bonsignore LA, Colbrunn RW, Tatro JM, Messerschmitt PJ, Hernandez CJ, Goldberg VM, Stewart MC, Greenfield EM. Surface contaminants inhibit osseointegration in a novel murine model. Bone. 49: 923-30. PMID 21801863 DOI: 10.1016/j.bone.2011.07.013  0.6
2011 Greenfield EM, Tatro JM, Smith MV, Schnaser EA, Wu D. PI3Kγ deletion reduces variability in the in vivo osteolytic response induced by orthopaedic wear particles. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 1649-53. PMID 21538508 DOI: 10.1002/jor.21440  0.6
2011 Islam AS, Beidelschies MA, Huml A, Greenfield EM. Titanium particles activate toll-like receptor 4 independently of lipid rafts in RAW264.7 murine macrophages. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 211-7. PMID 20806319 DOI: 10.1002/jor.21199  0.6
2010 Greenfield EM, Beidelschies MA, Tatro JM, Goldberg VM, Hise AG. Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. The Journal of Biological Chemistry. 285: 32378-84. PMID 20729214 DOI: 10.1074/jbc.M110.136895  0.6
2010 Gordon A, Greenfield EM, Eastell R, Kiss-Toth E, Wilkinson JM. Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 1127-35. PMID 20225323 DOI: 10.1002/jor.21135  0.6
2010 Greenfield EM, Chen X. Use of siRNA and antisense knockdown to study regulation of PKA by PKI Handbook of Cell Signaling, 2/E. 2: 1569-1572. DOI: 10.1016/B978-0-12-374145-5.00193-5  0.6
2009 Lu X, Rios HF, Jiang B, Xing L, Kadlcek R, Greenfield EM, Luo G, Feng JQ. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots. European Journal of Oral Sciences. 117: 625-35. PMID 20121924 DOI: 10.1111/j.1600-0722.2009.00690.x  0.6
2009 Unnanuntana A, Bonsignore L, Shirtliff ME, Greenfield EM. The effects of farnesol on Staphylococcus aureus biofilms and osteoblasts. An in vitro study. The Journal of Bone and Joint Surgery. American Volume. 91: 2683-92. PMID 19884443 DOI: 10.2106/JBJS.H.01699  0.6
2009 Messerschmitt PJ, Garcia RM, Abdul-Karim FW, Greenfield EM, Getty PJ. Osteosarcoma. The Journal of the American Academy of Orthopaedic Surgeons. 17: 515-27. PMID 19652033  0.6
2008 Beidelschies MA, Huang H, McMullen MR, Smith MV, Islam AS, Goldberg VM, Chen X, Nagy LE, Greenfield EM. Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK. Journal of Cellular Physiology. 217: 652-66. PMID 18651635 DOI: 10.1002/jcp.21539  0.6
2008 Greenfield EM, Bechtold J. What other biologic and mechanical factors might contribute to osteolysis? The Journal of the American Academy of Orthopaedic Surgeons. 16: S56-62. PMID 18612015  0.6
2008 Messerschmitt PJ, Rettew AN, Brookover RE, Garcia RM, Getty PJ, Greenfield EM. Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. Clinical Orthopaedics and Related Research. 466: 2168-75. PMID 18607665 DOI: 10.1007/s11999-008-0338-9  0.6
2007 Smith MV, Lee MJ, Islam AS, Rohrer JL, Goldberg VM, Beidelschies MA, Greenfield EM. Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-alpha production in response to titanium particles in vitro. The Journal of Bone and Joint Surgery. American Volume. 89: 1019-27. PMID 17473139 DOI: 10.2106/JBJS.F.00615  0.6
2007 Chen X, Song IH, Dennis JE, Greenfield EM. Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 656-64. PMID 17266398 DOI: 10.1359/jbmr.070122  0.6
2007 Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM. Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening. Bone. 40: 1276-83. PMID 17236833 DOI: 10.1016/j.bone.2006.12.053  0.6
2007 Tatro JM, Taki N, Islam AS, Goldberg VM, Rimnac CM, Doerschuk CM, Stewart MC, Greenfield EM. The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 25: 361-9. PMID 17106883 DOI: 10.1002/jor.20289  0.6
2006 Nalepka JL, Lee MJ, Kraay MJ, Marcus RE, Goldberg VM, Chen X, Greenfield EM. Lipopolysaccharide found in aseptic loosening of patients with inflammatory arthritis. Clinical Orthopaedics and Related Research. 451: 229-35. PMID 16735873 DOI: 10.1097/01.blo.0000224050.94248.38  0.6
2006 Fan X, Rahnert JA, Murphy TC, Nanes MS, Greenfield EM, Rubin J. Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. Journal of Cellular Physiology. 207: 454-60. PMID 16419041 DOI: 10.1002/jcp.20581  0.6
2006 Bi Y, Nielsen KL, Kilts TM, Yoon A, A Karsdal M, Wimer HF, Greenfield EM, Heegaard AM, Young MF. Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts. Bone. 38: 778-86. PMID 16364709 DOI: 10.1016/j.bone.2005.11.005  0.6
2006 Dai JC, He P, Chen X, Greenfield EM. TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics. Bone. 38: 509-20. PMID 16316790 DOI: 10.1016/j.bone.2005.10.007  0.6
2006 Rubin J, Murphy TC, Rahnert J, Song H, Nanes MS, Greenfield EM, Jo H, Fan X. Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase. The Journal of Biological Chemistry. 281: 1412-8. PMID 16306046 DOI: 10.1074/jbc.M508639200  0.6
2005 Taki N, Tatro JM, Nalepka JL, Togawa D, Goldberg VM, Rimnac CM, Greenfield EM. Polyethylene and titanium particles induce osteolysis by similar, lymphocyte-independent, mechanisms. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 23: 376-83. PMID 15734251 DOI: 10.1016/j.orthres.2004.08.023  0.6
2005 Chen X, Dai JC, Orellana SA, Greenfield EM. Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus. The Journal of Biological Chemistry. 280: 2700-7. PMID 15557275 DOI: 10.1074/jbc.M412558200  0.6
2005 Greenfield EM, Bi Y, Ragab AA, Goldberg VM, Nalepka JL, Seabold JM. Does endotoxin contribute to aseptic loosening of orthopedic implants? Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 72: 179-85. PMID 15449253 DOI: 10.1002/jbm.b.30150  0.6
2004 Nalepka JL, Greenfield EM. Detection of bacterial endotoxin in human tissues. Biotechniques. 37: 413-7. PMID 15470896  0.6
2002 Chen X, Dai JC, Greenfield EM. Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol. American Journal of Physiology. Cell Physiology. 283: C1432-40. PMID 12372804 DOI: 10.1152/ajpcell.00221.2002  0.6
2002 Ragab AA, Nalepka JL, Bi Y, Greenfield EM. Cytokines synergistically induce osteoclast differentiation: support by immortalized or normal calvarial cells. American Journal of Physiology. Cell Physiology. 283: C679-87. PMID 12176725 DOI: 10.1152/ajpcell.00421.2001  0.6
2002 Bi Y, Collier TO, Goldberg VM, Anderson JM, Greenfield EM. Adherent endotoxin mediates biological responses of titanium particles without stimulating their phagocytosis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 696-703. PMID 12168657 DOI: 10.1016/S0736-0266(01)00176-0  0.6
2002 Greenfield EM, Bi Y, Ragab AA, Goldberg VM, Van De Motter RR. The role of osteoclast differentiation in aseptic loosening. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 1-8. PMID 11855378 DOI: 10.1016/S0736-0266(01)00070-5  0.6
2001 Bi Y, Seabold JM, Kaar SG, Ragab AA, Goldberg VM, Anderson JM, Greenfield EM. Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 16: 2082-91. PMID 11697805 DOI: 10.1359/jbmr.2001.16.11.2082  0.6
2001 Kaar SG, Ragab AA, Kaye SJ, Kilic BA, Jinno T, Goldberg VM, Bi Y, Stewart MC, Carter JR, Greenfield EM. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 19: 171-8. PMID 11347687 DOI: 10.1016/S0736-0266(00)00033-4  0.6
2001 Bi Y, Van De Motter RR, Ragab AA, Goldberg VM, Anderson JM, Greenfield EM. Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts. The Journal of Bone and Joint Surgery. American Volume. 83: 501-8. PMID 11315778  0.6
1999 Ragab AA, Van De Motter R, Lavish SA, Goldberg VM, Ninomiya JT, Carlin CR, Greenfield EM. Measurement and removal of adherent endotoxin from titanium particles and implant surfaces Journal of Orthopaedic Research. 17: 803-809. PMID 10632445  0.6
1999 Greenfield EM, Bi Y, Miyauchi A. Regulation of osteoclast activity Life Sciences. 65: 1087-1102. PMID 10503925 DOI: 10.1016/S0024-3205(99)00156-3  0.6
1999 Ninomiya JT, Bi Y, Banks MA, Lavish SA, Goldberg VM, Greenfield EM. Bone marrow cells produce soluble factors that inhibit osteoclast activity. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 17: 51-8. PMID 10073647 DOI: 10.1002/jor.1100170109  0.6
1998 Ragab AA, Lavish SA, Banks MA, Goldberg VM, Greenfield EM. Osteoclast differentiation requires ascorbic acid. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 13: 970-7. PMID 9626628 DOI: 10.1359/jbmr.1998.13.6.970  0.6
1998 Greenfield EM. The role of interleukin-6 in stimulation of bone resorption by parathyroid hormone Cells and Materials. 7: 301-312.  0.6
1997 Greenfield EM, Goldberg VM. Genetic determination of bone density Lancet. 350: 1263-1264. PMID 9357401 DOI: 10.1016/S0140-6736(05)62468-3  0.6
1996 Pollock JH, Blaha MJ, Lavish SA, Stevenson S, Greenfield EM. In vivo demonstration that parathyroid hormone and parathyroid hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 11: 754-9. PMID 8725172 DOI: 10.1002/jbmr.5650110606  0.6
1996 Greenfield EM, Horowitz MC, Lavish SA. Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction Journal of Biological Chemistry. 271: 10984-10989. PMID 8631918 DOI: 10.1074/jbc.271.18.10984  0.6
1995 Greenfield EM, Shaw SM, Gornik SA, Banks MA. Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. The Journal of Clinical Investigation. 96: 1238-44. PMID 7657797 DOI: 10.1172/JCI118157  0.6
1993 Miyauchi A, Alvarez J, Greenfield EM, Teti A, Grano M, Colucci S, Zambonin-Zallone A, Ross FP, Teitelbaum SL, Cheresh D, Hruska KA. Binding of osteopontin to the osteoclast integrin αvβ3 Osteoporosis International. 3: 132-135. PMID 8461540 DOI: 10.1007/BF01621887  0.6
1993 Greenfield EM, Gornik SA, Horowitz MC, Donahue HJ, Shaw SM. Regulation of cytokine expression in osteoblasts by parathyroid hormone: rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 8: 1163-71. PMID 8256653 DOI: 10.1002/jbmr.5650081003  0.6
1992 Greenfield EM, Alvarez JI, McLaurine EA, Oursler MJ, Blair HC, Osdoby P, Teitelbaum SL, Patrick Ross F. Avian osteoblast conditioned media stimulate bone resorption by targeting multinucleating osteoclast precursors Calcified Tissue International. 51: 317-323. PMID 1422976 DOI: 10.1007/BF00334494  0.6
1992 Alvarez JI, Ross FP, Athanasou NA, Blair HC, Greenfield EM, Teitelbaum SL. Osteoclast precursors circulate in avian blood Calcified Tissue International. 51: 48-53. PMID 1393777 DOI: 10.1007/BF00296217  0.6
1991 Miyauchi A, Alvarez J, Greenfield EM, Teti A, Grano M, Colucci S, Zambonin-Zallone A, Ross FP, Teitelbaum SL, Cheresh D, Hruska KA. Recognition of osteopontin and related peptides by an αvβ3 integrin stimulates immediate cell signals in osteoclasts Journal of Biological Chemistry. 266: 20369-20374. PMID 1939092  0.6
1991 Alvarez JI, Teitelbaum SL, Blair HC, Greenfield EM, Athanasou NA, Ross FP. Generation of avian cells resembling osteoclasts from mononuclear phagocytes Endocrinology. 128: 2324-2335. PMID 1850350  0.6
1990 Miyauchi A, Hruska KA, Greenfield EM, Duncan R, Alvarez J, Barattolo R, Colucci S, Zambonin-Zallone A, Teitelbaum SL, Teti A. Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption Journal of Cell Biology. 111: 2543-2552. PMID 1703539  0.6
1984 Greenfield EM, Wilson DC, Crenshaw MA. Ionotropic nucleation of calcium carbonate by molluscan matrix Integrative and Comparative Biology. 24: 925-932. DOI: 10.1093/icb/24.4.925  0.6
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