| Year |
Citation |
Score |
| 2021 |
El-Desoky AHH, Inada N, Maeyama Y, Kato H, Hitora Y, Sebe M, Nagaki M, Kai A, Eguchi K, Inazumi T, Sugimoto Y, Frisvad JC, Williams RM, Tsukamoto S. Taichunins E-T, Isopimarane Diterpenes and a 20--Isopimarane, from (IBT 19404): Structures and Inhibitory Effects on RANKL-Induced Formation of Multinuclear Osteoclasts. Journal of Natural Products. PMID 34464116 DOI: 10.1021/acs.jnatprod.1c00486 |
0.337 |
|
| 2020 |
Ye Y, Du L, Zhang X, Newmister SA, McCauley M, Alegre-Requena JV, Zhang W, Mu S, Minami A, Fraley AE, Adrover-Castellano ML, Carney NA, Shende VV, Qi F, Oikawa H, ... Williams RM, et al. Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nature Catalysis. 3: 497-506. PMID 32923978 DOI: 10.1038/s41929-020-0454-9 |
0.414 |
|
| 2020 |
Sadahiro Y, Kato H, Williams RM, Tsukamoto S. Irpexine, an Isoindolinone Alkaloid Produced by Coculture of Endophytic Fungi, and . Journal of Natural Products. PMID 32301614 DOI: 10.1021/Acs.Jnatprod.0C00047 |
0.445 |
|
| 2020 |
Fraley AE, Tran HT, Kelly SP, Newmister SA, Tripathi A, Kato H, Tsukamoto S, Du L, Li S, Williams RM, Sherman DH. Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides. Chembiochem : a European Journal of Chemical Biology. PMID 32246875 DOI: 10.1002/Cbic.202000004 |
0.491 |
|
| 2020 |
Li S, Newmister SA, Lowell AN, Zi J, Chappell CR, Yu F, Hohlman RM, Orjala J, Williams RM, Sherman DH. Control of stereoselectivity in diverse hapalindole metabolites is mediated by cofactor induced combinatorial pairing of Stig cyclases. Angewandte Chemie (International Ed. in English). PMID 32052896 DOI: 10.1002/Anie.201913686 |
0.467 |
|
| 2020 |
Thielman JR, Sherman DH, Williams RM. Stereoselective Synthesis of Baulamycin A. The Journal of Organic Chemistry. PMID 31970985 DOI: 10.1021/Acs.Joc.9B03443 |
0.814 |
|
| 2020 |
Fraley A, Caddell Haatveit K, Ye Y, Kelly SP, Newmister SA, Yu F, Williams RM, Smith JL, Houk KN, Sherman DH. Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway. Journal of the American Chemical Society. PMID 31904957 DOI: 10.2210/Pdb6Pvi/Pdb |
0.465 |
|
| 2019 |
Dan Q, Newmister SA, Klas KR, Fraley AE, McAfoos TJ, Somoza AD, Sunderhaus JD, Ye Y, Shende VV, Yu F, Sanders JN, Brown WC, Zhao L, Paton RS, Houk KN, ... Williams RM, et al. Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nature Chemistry. PMID 31548667 DOI: 10.1038/S41557-019-0326-6 |
0.817 |
|
| 2019 |
Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG. Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America. PMID 31337679 DOI: 10.1073/Pnas.1818547116 |
0.394 |
|
| 2019 |
Kato H, Sebe M, Nagaki M, Eguchi K, Kagiyama I, Hitora Y, Frisvad JC, Williams RM, Tsukamoto S. Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404). Journal of Natural Products. PMID 30995043 DOI: 10.1021/acs.jnatprod.8b01032 |
0.301 |
|
| 2019 |
Dan Q, Newmister SA, Klas KR, Fraley AE, Paton RS, Houk KN, Williams RM, Sherman DH, Smith JL. Evolution of a bifunctional reductase/Diels–Alderase for fungal indole alkaloid biosynthesis Acta Crystallographica Section a Foundations and Advances. 75: a244-a245. DOI: 10.1107/S0108767319097599 |
0.326 |
|
| 2018 |
Kai A, Kato H, Sherman DH, Williams RM, Tsukamoto S. Isolation of a new indoxyl alkaloid, Amoenamide B, from NRRL 35600: biosynthetic implications and correction of the structure of Speramide B. Tetrahedron Letters. 50: 4236-4240. PMID 30765898 DOI: 10.1016/J.Tetlet.2018.10.034 |
0.422 |
|
| 2018 |
Newmister SA, Romminger S, Schmidt JJ, Williams RM, Smith JL, Berlinck RGS, Sherman DH. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. Organic & Biomolecular Chemistry. PMID 30141817 DOI: 10.1039/C8Ob01565A |
0.453 |
|
| 2018 |
Kato H, Kai A, Kawabata T, Sunderhaus JD, McAfoos TJ, Finefield JM, Sugimoto Y, Williams RM, Tsukamoto S. Corrigendum to "Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts" [Bioorg. Med. Chem. Lett. 27 (22) (2017) 4975-4978]. Bioorganic & Medicinal Chemistry Letters. PMID 29903661 DOI: 10.1016/J.Bmcl.2018.06.013 |
0.777 |
|
| 2018 |
Klas KR, Kato H, Frisvad JC, Yu F, Newmister SA, Fraley AE, Sherman DH, Tsukamoto S, Williams RM. Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi. Natural Product Reports. PMID 29632911 DOI: 10.1039/C7Np00042A |
0.517 |
|
| 2018 |
Newmister SA, Li S, Garcia-Borràs M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH. Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis. Nature Chemical Biology. PMID 29531360 DOI: 10.1038/S41589-018-0003-X |
0.498 |
|
| 2017 |
Zhao L, Dunne CE, Clausen DJ, Roberts JM, Paulk J, Liu H, Wiest OG, Bradner JE, Williams RM. Synthesis and Biochemical Evaluation of Biotinylated Conjugates of Largazole Analogues: Selective Class I Histone Deacetylase Inhibitors. Israel Journal of Chemistry. 57: 319-330. PMID 30760938 DOI: 10.1002/Ijch.201600130 |
0.464 |
|
| 2017 |
Sugimoto K, Sadahiro Y, Kagiyama I, Kato H, Sherman DH, Williams RM, Tsukamoto S. Isolation of amoenamide A and five antipodal prenylated alkaloids fromNRRL 35600. Tetrahedron Letters. 58: 2797-2800. PMID 29622844 DOI: 10.1016/J.Tetlet.2017.05.057 |
0.432 |
|
| 2017 |
Kato H, Nakahara T, Sugimoto K, Matsuo K, Kagiyama I, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Correction to "Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications". Organic Letters. PMID 29235872 DOI: 10.1021/Acs.Orglett.7B03781 |
0.389 |
|
| 2017 |
Kato H, Kai A, Kawabata T, Sunderhaus JD, McAfoos TJ, Finefield JM, Sugimoto Y, Williams RM, Tsukamoto S. Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts. Bioorganic & Medicinal Chemistry Letters. PMID 29037945 DOI: 10.1016/J.Bmcl.2017.10.017 |
0.78 |
|
| 2017 |
Albert BJ, Niu A, Ramani R, Marshall GR, Wender PA, Williams RM, Ratner L, Barnes AB, Kyei GB. Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation. Scientific Reports. 7: 7456. PMID 28785069 DOI: 10.1038/S41598-017-07814-4 |
0.394 |
|
| 2017 |
Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb G, Watts K, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH. Function and structure of MalA/MalA', iterative halogenases for late-stage C-H functionalization of indole alkaloids. Journal of the American Chemical Society. PMID 28777910 DOI: 10.1021/Jacs.7B06773 |
0.504 |
|
| 2017 |
Bacon K, Boyer R, Denbow C, O'Keefe S, Neilson A, Williams R. Antibacterial activity of jalapeño pepper (Capsicum annuum var. annuum) extract fractions against select foodborne pathogens. Food Science & Nutrition. 5: 730-738. PMID 28572963 DOI: 10.1002/fsn3.453 |
0.317 |
|
| 2017 |
Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chemical Biology. PMID 28288107 DOI: 10.1038/Nchembio.2327 |
0.466 |
|
| 2016 |
Loignon C, Gottin T, Valois C, Couturier F, Williams R, Roy PM. Canadian Family Physician Medecin De Famille Canadien. 62: 912-918. PMID 28661873 |
0.319 |
|
| 2016 |
Newmister SA, Gober CM, Romminger S, Yu F, Tripathi A, Parra LL, Williams RM, Berlinck RG, Joullié MM, Sherman DH. OxaD, a versatile indolic nitrone synthase from the marine-derived fungus Penicillium oxalicum F30. Journal of the American Chemical Society. PMID 27505044 DOI: 10.1021/Jacs.6B04915 |
0.487 |
|
| 2016 |
Yokoya M, Toyoshima R, Suzuki T, Le VH, Williams RM, Saito N. Stereoselective Total Synthesis of (-)-Renieramycin T. The Journal of Organic Chemistry. PMID 27019081 DOI: 10.1021/Acs.Joc.6B00327 |
0.509 |
|
| 2015 |
Kagiyama I, Kato H, Nehira T, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404). Angewandte Chemie (International Ed. in English). PMID 26644336 DOI: 10.1002/Anie.201509462 |
0.489 |
|
| 2015 |
Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH. Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade. Journal of the American Chemical Society. PMID 26629885 DOI: 10.1021/Jacs.5B10136 |
0.496 |
|
| 2015 |
Klas K, Tsukamoto S, Sherman DH, Williams RM. Natural Diels-Alderases: Elusive and Irresistable. The Journal of Organic Chemistry. PMID 26495876 DOI: 10.1021/Acs.Joc.5B01951 |
0.447 |
|
| 2015 |
Sherman DH, Tsukamoto S, Williams RM. ORGANIC SYNTHESIS. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence". Science (New York, N.Y.). 349: 149. PMID 26160938 DOI: 10.1126/Science.Aaa9349 |
0.453 |
|
| 2015 |
Clausen DJ, Smith WB, Haines BE, Wiest O, Bradner JE, Williams RM. Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole. Bioorganic & Medicinal Chemistry. 23: 5061-74. PMID 26054247 DOI: 10.1016/J.Bmc.2015.03.063 |
0.482 |
|
| 2015 |
Decroos C, Clausen DJ, Haines BE, Wiest O, Williams RM, Christianson DW. Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8. Biochemistry. 54: 2126-35. PMID 25793284 DOI: 10.1021/Acs.Biochem.5B00010 |
0.443 |
|
| 2015 |
Kato H, Nakahara T, Yamaguchi M, Kagiyama I, Finefield JM, Sunderhaus JD, Sherman DH, Williams RM, Tsukamoto S. Bioconversion of 6-epi-Notoamide T Produces Metabolites of Unprecedented Structures in a Marine-derived Aspergillus sp. Tetrahedron Letters. 56: 247-251. PMID 25767298 DOI: 10.1016/J.Tetlet.2014.11.083 |
0.766 |
|
| 2015 |
Pilon JL, Clausen DJ, Hansen RJ, Lunghofer PJ, Charles B, Rose BJ, Thamm DH, Gustafson DL, Bradner JE, Williams RM. Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere. Cancer Chemotherapy and Pharmacology. 75: 671-82. PMID 25616967 DOI: 10.1007/S00280-015-2675-1 |
0.441 |
|
| 2015 |
Kato H, Nakahara T, Sugimoto K, Matsuo K, Kagiyama I, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S. Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungus Aspergillus amoenus: biogenetic implications. Organic Letters. 17: 700-3. PMID 25615822 DOI: 10.1021/Ol5037198 |
0.333 |
|
| 2014 |
Williams R. Discontinued in 2013: oncology drugs. Expert Opinion On Investigational Drugs. 24: 95-110. PMID 25315907 DOI: 10.1517/13543784.2015.971154 |
0.305 |
|
| 2014 |
Pearson AD, Williams RM. Synthetic studies towards Zetekitoxin AB: preparation of 4,5-epi-11-hydroxy-saxitoxinol. Tetrahedron. 70: 7942-7949. PMID 25313264 DOI: 10.1016/J.Tet.2014.08.058 |
0.695 |
|
| 2014 |
O'Byrne PM, Williams R, Walsh JJ, Gilmer JF. Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion. Part one: in vitro development. Pharmaceuticals (Basel, Switzerland). 7: 595-620. PMID 24830986 DOI: 10.3390/ph7050595 |
0.339 |
|
| 2014 |
Welch TR, Williams RM. Epidithiodioxopiperazines. occurrence, synthesis and biogenesis. Natural Product Reports. 31: 1376-404. PMID 24816491 DOI: 10.1039/C3Np70097F |
0.658 |
|
| 2014 |
Pan G, Williams RM. Efficient Synthesis of the Cyclopentanone Fragrances (Z)-3-(2-oxopropyl)-2-(pent-2-en-1-yl)cyclopentanone and Magnolione. Tetrahedron. 70: 276-279. PMID 24729640 DOI: 10.1016/J.Tet.2013.11.066 |
0.602 |
|
| 2014 |
Chen Z, Forman LW, Williams RM, Faller DV. Protein kinase C-δ inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo. Bmc Cancer. 14: 90. PMID 24528676 DOI: 10.1186/1471-2407-14-90 |
0.396 |
|
| 2014 |
Takashima A, English B, Chen Z, Cao J, Cui R, Williams RM, Faller DV. Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation. Acs Chemical Biology. 9: 1003-14. PMID 24506253 DOI: 10.1021/Cb400837T |
0.548 |
|
| 2014 |
Kato H, Nakamura Y, Finefield JM, Umaoka H, Nakahara T, Williams RM, Tsukamoto S. Corrigendum to "study on the biosynthesis of the notoamides: Pinacol-type rearrangement of the isoprenyl unit in deoxybrevianamide e and 6-hydroxydeoxybrevianamide E" [Tetrahedron Lett. 52 (2011) 6923-6926] Tetrahedron Letters. 55: 559-560. DOI: 10.1016/J.Tetlet.2013.11.076 |
0.69 |
|
| 2013 |
Jiménez-Somarribas A, Williams RM. Synthetic studies on lemonomycin: construction of the tetracyclic core. Tetrahedron. 69: 7505-7512. PMID 25083002 DOI: 10.1016/J.Tet.2013.05.009 |
0.796 |
|
| 2013 |
Welch TR, Williams RM. Studies on the Biosynthesis of Chetomin: Enantiospecific Synthesis of a Putative, Late-Stage Biosynthetic Intermediate. Tetrahedron. 69: 770-773. PMID 24489414 DOI: 10.1016/J.Tet.2012.10.075 |
0.678 |
|
| 2013 |
Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM. Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs. Bioorganic & Medicinal Chemistry Letters. 23: 6025-8. PMID 24035339 DOI: 10.1016/J.Bmcl.2013.06.012 |
0.698 |
|
| 2013 |
Bass PD, Gubler DA, Judd TC, Williams RM. Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches. Chemical Reviews. 113: 6816-63. PMID 23654296 DOI: 10.1021/Cr3001059 |
0.783 |
|
| 2013 |
Sunderhaus JD, McAfoos TJ, Finefield JM, Kato H, Li S, Tsukamoto S, Sherman DH, Williams RM. Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B. Organic Letters. 15: 22-5. PMID 23249380 DOI: 10.1021/Ol302901P |
0.782 |
|
| 2013 |
Finefield JM, Williams RM. Correction to Synthesis of Notoamide J: A Potentially Pivotal Intermediate in the Biosynthesis of Several Prenylated Indole Alkaloids The Journal of Organic Chemistry. 78: 8214-8214. DOI: 10.1021/Jo401209S |
0.778 |
|
| 2013 |
Tsukamoto S, Kato H, Greshock TJ, Hirota H, Ohta T, Williams RM. Correction to Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-Derived Fungus, Aspergillus sp. Journal of the American Chemical Society. 135: 10878-10878. DOI: 10.1021/Ja405894M |
0.31 |
|
| 2012 |
Rafferty RJ, Williams RM. FORMAL SYNTHESIS OF HAPALINDOLE O AND SYNTHETIC EFFORTS TOWARDS HAPALINDOLE K AND AMBIGUINE A. Heterocycles. 86: 219-231. PMID 24808627 DOI: 10.3987/Com-12-S(N)3 |
0.804 |
|
| 2012 |
Schuber PT, Williams RM. SYNTHETIC STUDIES ON MPC1001: A DIPOLAR CYCLOADDITION APPROACH TO THE PYRROLIDINE RING SYSTEM. Heterocycles. 84: 1193-1207. PMID 23667292 DOI: 10.3987/Com-11-S(P)101 |
0.805 |
|
| 2012 |
Li S, Anand K, Tran H, Yu F, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH. Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm. 3: 987-996. PMID 23213353 DOI: 10.1039/C2Md20029E |
0.792 |
|
| 2012 |
Walldén K, Williams R, Yan J, Lian PW, Wang L, Thalassinos K, Orlova EV, Waksman G. Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system. Proceedings of the National Academy of Sciences of the United States of America. 109: 11348-53. PMID 22745169 DOI: 10.1073/Pnas.1201428109 |
0.309 |
|
| 2012 |
Wu S, Jiang Z, Kempinski C, Eric Nybo S, Husodo S, Williams R, Chappell J. Engineering triterpene metabolism in tobacco. Planta. 236: 867-77. PMID 22729821 DOI: 10.1007/S00425-012-1680-4 |
0.32 |
|
| 2012 |
Finefield JM, Sherman DH, Kreitman M, Williams RM. Enantiomeric natural products: occurrence and biogenesis. Angewandte Chemie (International Ed. in English). 51: 4802-36. PMID 22555867 DOI: 10.1002/Anie.201107204 |
0.758 |
|
| 2012 |
Guerra-Bubb J, Croteau R, Williams RM. The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites. Natural Product Reports. 29: 683-96. PMID 22547034 DOI: 10.1039/C2Np20021J |
0.461 |
|
| 2012 |
Pan G, Williams RM. Unified total syntheses of fawcettimine class alkaloids: fawcettimine, fawcettidine, lycoflexine, and lycoposerramine B. The Journal of Organic Chemistry. 77: 4801-11. PMID 22519642 DOI: 10.1021/Jo3006045 |
0.66 |
|
| 2012 |
Finefield JM, Frisvad JC, Sherman DH, Williams RM. Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids. Journal of Natural Products. 75: 812-33. PMID 22502590 DOI: 10.1021/Np200954V |
0.777 |
|
| 2012 |
Schuber PT, Williams RM. Synthetic Studies Towards MPC1001: Preparation of a β-hydroxyl-Tyrosine Derivative. Tetrahedron Letters. 53: 380-382. PMID 22287813 DOI: 10.1016/J.Tetlet.2011.11.069 |
0.805 |
|
| 2012 |
Li S, Finefield JM, Sunderhaus JD, McAfoos TJ, Williams RM, Sherman DH. Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. Journal of the American Chemical Society. 134: 788-91. PMID 22188465 DOI: 10.1021/Ja2093212 |
0.805 |
|
| 2012 |
Ghosh SK, Perrine SP, Williams RM, Faller DV. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Blood. 119: 1008-17. PMID 22160379 DOI: 10.1182/Blood-2011-06-362434 |
0.416 |
|
| 2012 |
Rafferty RJ, Williams RM. Total synthesis of hapalindoles J and U. The Journal of Organic Chemistry. 77: 519-24. PMID 22126131 DOI: 10.1021/Jo202139K |
0.806 |
|
| 2012 |
Li S, Finefield JM, Sunderhaus JD, McAfoos TJ, Williams RM, Sherman DH. Correction to “Biochemical Characterization of NotB as an FAD-Dependent Oxidase in the Biosynthesis of Notoamide Indole Alkaloids” Journal of the American Chemical Society. 134: 20565-20565. DOI: 10.1021/Ja3107753 |
0.773 |
|
| 2012 |
Finefield JM, Sherman DH, Kreitman M, Williams RM. Enantiomere Naturstoffe: Vorkommen und Biogenese Angewandte Chemie. 124: 4886-4920. DOI: 10.1002/Ange.201107204 |
0.733 |
|
| 2011 |
Kato H, Nakamura Y, Finefield JM, Umaoka H, Nakahara T, Williams RM, Tsukamoto S. Study on the biosynthesis of the notoamides: Pinacol-type rearrangement of the isoprenyl unit in deoxybrevianamide E and 6-hydroxydeoxybrevianamide E. Tetrahedron Letters. 52: 6923-6926. PMID 22140281 DOI: 10.1016/J.Tetlet.2011.10.065 |
0.752 |
|
| 2011 |
Finefield JM, Greshock TJ, Sherman DH, Tsukamoto S, Williams RM. Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600. Tetrahedron Letters. 52: 1987-1989. PMID 22140279 DOI: 10.1016/J.Tetlet.2011.02.078 |
0.757 |
|
| 2011 |
Chen Z, Forman LW, Miller KA, English B, Takashima A, Bohacek RA, Williams RM, Faller DV. Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. Endocrine-Related Cancer. 18: 759-71. PMID 21990324 DOI: 10.1530/Erc-10-0224 |
0.637 |
|
| 2011 |
Williams RM, Stille J, Echavarren A, Hendrix J, Albrecht B, Williams R. Discussion Addendum for: 4-Methoxy-4'-nitrophenyl. Recent Advances in the Stille Biaryl Coupling Reaction and Applications in Complex Natural Products Synthesis. Organic Syntheses; An Annual Publication of Satisfactory Methods For the Preparation of Organic Chemicals. 88: 197-201. PMID 21960729 DOI: 10.1002/0471264229.Os088.18 |
0.729 |
|
| 2011 |
Rath CM, Janto B, Earl J, Ahmed A, Hu FZ, Hiller L, Dahlgren M, Kreft R, Yu F, Wolff JJ, Kweon HK, Christiansen MA, Håkansson K, Williams RM, Ehrlich GD, et al. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. Acs Chemical Biology. 6: 1244-56. PMID 21875091 DOI: 10.1021/Cb200244T |
0.46 |
|
| 2011 |
Sunderhaus JD, Sherman DH, Williams RM. Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum. Israel Journal of Chemistry. 51: 442-452. PMID 21818159 DOI: 10.1002/Ijch.201100016 |
0.5 |
|
| 2011 |
Finefield JM, Kato H, Greshock TJ, Sherman DH, Tsukamoto S, Williams RM. Biosynthetic studies of the notoamides: isotopic synthesis of stephacidin A and incorporation into notoamide B and sclerotiamide. Organic Letters. 13: 3802-5. PMID 21714564 DOI: 10.1021/Ol201284Y |
0.771 |
|
| 2011 |
Rafferty RJ, Williams RM. Synthetic Studies on the Ambiguine Family of Alkaloids: Construction of the ABCD Ring System. Tetrahedron Letters. 52: 2037-2040. PMID 21516192 DOI: 10.1016/J.Tetlet.2010.09.086 |
0.804 |
|
| 2011 |
Finefield JM, Sherman DH, Tsukamoto S, Williams RM. Studies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide E and biosynthetic incorporation into notoamide J. The Journal of Organic Chemistry. 76: 5954-8. PMID 21504234 DOI: 10.1021/Jo200218A |
0.783 |
|
| 2011 |
Williams RM. Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism. The Journal of Organic Chemistry. 76: 4221-59. PMID 21438619 DOI: 10.1021/Jo2003693 |
0.508 |
|
| 2011 |
Vincent G, Williams RM. Corrigendum: Asymmetric Total Synthesis of (−)-Cribrostatin 4 (Renieramycin H) Angewandte Chemie International Edition. 50: 8458-8458. DOI: 10.1002/Anie.201190074 |
0.31 |
|
| 2011 |
Welch TR, Williams RM. Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Dioxopiperazine Alkaloids Biomimetic Organic Synthesis. 1: 117-148. DOI: 10.1002/9783527634606.ch4 |
0.606 |
|
| 2010 |
McAfoos TJ, Li S, Tsukamoto S, Sherman DH, Williams RM. STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S. Heterocycles. 82: 461-472. PMID 21796227 DOI: 10.3987/Com-10-S(E)19 |
0.81 |
|
| 2010 |
Namba K, Inai M, Sundermeier U, Greshock TJ, Williams RM. Synthetic Studies on Palau'amine. Construction of the Cyclopentane Core via an Asymmetric 1,3-Dipolar Cycloaddition. Tetrahedron Letters. 51: 6557-6559. PMID 21286237 DOI: 10.1016/J.Tetlet.2010.10.037 |
0.466 |
|
| 2010 |
English BJ, Williams RM. A divergent strategy for the synthesis of secologanin derived natural products. The Journal of Organic Chemistry. 75: 7869-76. PMID 20964396 DOI: 10.1021/Jo101775N |
0.398 |
|
| 2010 |
Ding Y, de Wet JR, Cavalcoli J, Li S, Greshock TJ, Miller KA, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH. Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. Journal of the American Chemical Society. 132: 12733-40. PMID 20722388 DOI: 10.1021/Ja1049302 |
0.8 |
|
| 2010 |
Finefield JM, Williams RM. Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids. The Journal of Organic Chemistry. 75: 2785-9. PMID 20359229 DOI: 10.1021/Jo100332C |
0.806 |
|
| 2010 |
Subramanian V, Williams RM, Boger DL, Luger K. Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA. Methods in Molecular Biology (Clifton, N.J.). 613: 173-92. PMID 19997884 DOI: 10.1007/978-1-60327-418-0_11 |
0.381 |
|
| 2010 |
Stocking EM, Sanz-Cervera JF, Williams RM. ChemInform Abstract: Total Synthesis of VM55599. Utilization of an Intramolecular Diels-Alder Cycloaddition of Potential Biogenetic Relevance. Cheminform. 31: no-no. DOI: 10.1002/chin.200021234 |
0.307 |
|
| 2010 |
ROLLINS BS, WILLIAMS RM. ChemInform Abstract: Synthetic Studies on FR 900482. Synthesis of a Photo-Triggered Pro- Mitosene. Cheminform. 28: no-no. DOI: 10.1002/chin.199737268 |
0.306 |
|
| 2010 |
WILLIAMS RM, IM M, CAO J. ChemInform Abstract: Asymmetric Synthesis of 2,6-Diamino-6-(hydroxymethyl)pimelic Acid: Assignment of Stereochemistry. Cheminform. 22: no-no. DOI: 10.1002/chin.199150239 |
0.496 |
|
| 2009 |
Artman GD, Rafferty RJ, Williams RM, Aaron GL, Davis MM, Brummond KM. (3R,7aS)-3-(TRICHLOROMETHYL)TETRAHYDROPYRROLO[1,2-C]OXAZOL-1(3H)-ONE: AN AIR AND MOISTURE STABLE REAGENT FOR THE SYNTHESIS OF OPTICALLY ACTIVE α-BRANCHED PROLINES. Organic Syntheses; An Annual Publication of Satisfactory Methods For the Preparation of Organic Chemicals. 86: 262. PMID 21331348 |
0.764 |
|
| 2009 |
Williams RM, Burnett CM. New Tricks in Amino Acid Synthesis: Applications to Complex Natural Products. Acs Symposium Series. American Chemical Society. 1009: 420-442. PMID 20563264 DOI: 10.1021/bk-2009-1009.ch026 |
0.699 |
|
| 2009 |
Miller KA, Tsukamoto S, Williams RM. Asymmetric total syntheses of (+)- and (-)-versicolamide B and biosynthetic implications. Nature Chemistry. 1: 63-8. PMID 20300443 DOI: 10.1038/Nchem.110 |
0.707 |
|
| 2009 |
Burnett CM, Williams RM. Asymmetric Synthesis of the Core of AMPTD, the Key Amino Acid of Microsclerodermins F-I. Tetrahedron Letters. 50: 5449-5451. PMID 20191096 DOI: 10.1016/J.Tetlet.2009.06.144 |
0.723 |
|
| 2009 |
English BJ, Williams RM. Synthesis of (+/-)-Oleocanthal via a Tandem Intramolecular Michael Cyclization-HWE Olefination. Tetrahedron Letters. 50: 2713. PMID 20161637 DOI: 10.1016/J.Tetlet.2009.03.145 |
0.553 |
|
| 2009 |
Sommer K, Williams RM. Studies on Paraherquamide Biosynthesis: Synthesis of Deuterium-Labeled 7-Hydroxy-Pre-Paraherquamide, a Putative Precursor of Paraherquamides A, E & F. Tetrahedron. 65: 3246-3260. PMID 20161298 DOI: 10.1016/J.Tet.2008.08.102 |
0.494 |
|
| 2009 |
Gubler DA, Williams RM. Synthetic Studies Towards the Mitomycins: Construction of the Tetracyclic Core via a Reductive Aminocyclization Reaction. Tetrahedron Letters. 50: 4265-4267. PMID 20161278 DOI: 10.1016/J.Tetlet.2009.05.004 |
0.8 |
|
| 2009 |
Miller KA, Williams RM. Synthetic approaches to the bicyclo[2.2.2]diazaoctane ring system common to the paraherquamides, stephacidins and related prenylated indole alkaloids. Chemical Society Reviews. 38: 3160-74. PMID 19847349 DOI: 10.1039/B816705M |
0.72 |
|
| 2009 |
Newkirk TL, Bowers AA, Williams RM. Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors. Natural Product Reports. 26: 1293-320. PMID 19779641 DOI: 10.1039/B817886K |
0.778 |
|
| 2009 |
Namba K, Kaihara Y, Yamamoto H, Imagawa H, Tanino K, Williams RM, Nishizawa M. Toward Palau'amine: Hg(OTf)2-Catalyzed synthesis of the cyclopentane core Chemistry - a European Journal. 15: 6560-6563. PMID 19492366 DOI: 10.1002/Chem.200900622 |
0.554 |
|
| 2009 |
Tsukamoto S, Kato H, Greshock TJ, Hirota H, Ohta T, Williams RM. Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp. Journal of the American Chemical Society. 131: 3834-5. PMID 19292484 DOI: 10.1021/Ja810029B |
0.376 |
|
| 2009 |
Tsukamoto S, Kawabata T, Kato H, Greshock TJ, Hirota H, Ohta T, Williams RM. Isolation of antipodal (-)-versicolamide B and notoamides L-N from a marine-derived Aspergillus sp. Organic Letters. 11: 1297-300. PMID 19281134 DOI: 10.1021/Ol900071C |
0.366 |
|
| 2009 |
Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, Williams RM. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Organic Letters. 11: 1301-4. PMID 19239241 DOI: 10.1021/Ol900078K |
0.781 |
|
| 2009 |
Bowers AA, Greshock TJ, West N, Estiu G, Schreiber SL, Wiest O, Williams RM, Bradner JE. Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. Journal of the American Chemical Society. 131: 2900-5. PMID 19193120 DOI: 10.1021/Ja807772W |
0.702 |
|
| 2009 |
Chamberland S, Grüschow S, Sherman DH, Williams RM. Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C. Organic Letters. 11: 791-4. PMID 19161340 DOI: 10.1021/Ol802631C |
0.667 |
|
| 2009 |
Li Z, Hu M, Leung C, Steinberg JA, Shen J, Li M, Wang CS, Sanchez E, Bowers A, Greshock T, Miller K, Newkirk T, West N, Bradner JE, Williams RM, et al. Largazole, a Novel Cyclic Peptide Histone Deacetylase Inhibitor, Demonstrates Anti-MM Effects Alone and Increases the Anti-MM Effects of Bortezomib. Blood. 114: 4925-4925. DOI: 10.1182/Blood.V114.22.4925.4925 |
0.764 |
|
| 2009 |
Cao H, Fei RG, Bowers AA, Greshock TJ, Newkirt T, Miller KA, Bradner JE, West N, Williams RM, Papayannopoulou T, Stamatoyannopoulos G. Potent Induction of Human γ Globin Gene Expression by Largazole, a New Histone Deacetylase Inhibitor. Blood. 114: 2022-2022. DOI: 10.1182/Blood.V114.22.2022.2022 |
0.731 |
|
| 2009 |
Li Z, Shalitin D, Finefield J, Leung C, Hu M, Shen J, Li M, Wang CS, Steinberg JA, Sanchez E, Chen H, Williams RM, Bonavida B, Berenson JR. Multiple Myeloma-Specific Targeted Therapy: Use of the Tumor Specific Immunoglobulin Gene Sequence to Activate Drugs Only within Tumor Cells. Blood. 114: 1851-1851. DOI: 10.1182/Blood.V114.22.1851.1851 |
0.72 |
|
| 2009 |
Miller KA, Tsukamoto S, Williams RM. Erratum: Asymmetric total syntheses of (+)- and (−)-versicolamide B and biosynthetic implications Nature Chemistry. 1: 165-165. DOI: 10.1038/Nchem.195 |
0.624 |
|
| 2008 |
Sommer K, Williams RM. Studies Towards Paraherquamides E & F and Related C-labeled Putative Biosynthetic Intermediates: Stereocontrolled Synthesis of the α-Alkyl-β-Methylproline Ring System. Tetrahedron. 64: 7106-7111. PMID 20336192 DOI: 10.1016/J.Tet.2008.05.068 |
0.508 |
|
| 2008 |
Horiguchi T, Rithner CD, Croteau R, Williams RM. Studies on Taxol® Biosynthesis. Preparation and Tritium Labeling of Biosynthetic intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from Japanese Yew. Journal of Labelled Compounds & Radiopharmaceuticals. 51: 325-328. PMID 20221307 DOI: 10.1002/Jlcr.1529 |
0.443 |
|
| 2008 |
Jia X, Williams RM. A Diastereoselective Intramolecular Pauson-Khand Approach to the Construction of the BC Ring System in Tuberostemoninol. Tetrahedron, Asymmetry. 19: 2901-2906. PMID 19779590 DOI: 10.1016/J.Tetasy.2008.11.022 |
0.691 |
|
| 2008 |
Li H, Horiguchi T, Croteau R, Williams RM. Studies on Taxol Biosynthesis: Preparation of Taxadiene-diol- and triol-Derivatives by Deoxygenation of Taxusin. Tetrahedron. 64: 6561-6567. PMID 19122848 DOI: 10.1016/J.Tet.2008.04.008 |
0.422 |
|
| 2008 |
Miller KA, Figueroa M, Valente MW, Greshock TJ, Mata R, Williams RM. Calmodulin inhibitory activity of the malbrancheamides and various analogs. Bioorganic & Medicinal Chemistry Letters. 18: 6479-81. PMID 18986806 DOI: 10.1016/J.Bmcl.2008.10.057 |
0.682 |
|
| 2008 |
Ding Y, Greshock TJ, Miller KA, Sherman DH, Williams RM. Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Organic Letters. 10: 4863-6. PMID 18844365 DOI: 10.1021/Ol8019633 |
0.649 |
|
| 2008 |
Ding Y, Gruschow S, Greshock TJ, Finefield JM, Sherman DH, Williams RM. Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications. Journal of Natural Products. 71: 1574-8. PMID 18754595 DOI: 10.1021/Np800292N |
0.738 |
|
| 2008 |
Fishlock D, Williams RM. Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis. The Journal of Organic Chemistry. 73: 9594-600. PMID 18687003 DOI: 10.1021/Jo801159K |
0.502 |
|
| 2008 |
Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 11219-22. PMID 18642817 DOI: 10.1021/Ja8033763 |
0.741 |
|
| 2008 |
Ding Y, Williams RM, Sherman DH. Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. The Journal of Biological Chemistry. 283: 16068-76. PMID 18390548 DOI: 10.1074/Jbc.M801991200 |
0.387 |
|
| 2008 |
Greshock TJ, Grubbs AW, Jiao P, Wicklow DT, Gloer JB, Williams RM. Isolation, structure elucidation, and biomimetic total synthesis of versicolamide B, and the isolation of antipodal (-)-stephacidin A and (+)-notoamide B from Aspergillus versicolor NRRL 35600. Angewandte Chemie (International Ed. in English). 47: 3573-7. PMID 18389509 DOI: 10.1002/Anie.200800106 |
0.519 |
|
| 2008 |
Miller KA, Welch TR, Greshock TJ, Ding Y, Sherman DH, Williams RM. Biomimetic total synthesis of malbrancheamide and malbrancheamide B. The Journal of Organic Chemistry. 73: 3116-9. PMID 18345688 DOI: 10.1021/Jo800116Y |
0.759 |
|
| 2008 |
Smith AC, Williams RM. Rabe rest in peace: confirmation of the rabe-kindler conversion of D-quinotoxine into quinine: experimental affirmation of the Woodward-Doering formal total synthesis of quinine. Angewandte Chemie (International Ed. in English). 47: 1736-40. PMID 18236503 DOI: 10.1002/Anie.200705421 |
0.455 |
|
| 2008 |
Greshock TJ, Johns DM, Noguchi Y, Williams RM. Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228). Organic Letters. 10: 613-6. PMID 18205373 DOI: 10.1021/Ol702957Z |
0.518 |
|
| 2008 |
Williams R, Greshock T, Johns D, Noguchi Y. Synthesis of FK228 Synfacts. 2008: 0669-0669. DOI: 10.1055/S-2008-1077866 |
0.414 |
|
| 2008 |
Williams RM. Book Review of Modern Alkaloids: Structure, Isolation, Synthesis and Biology Journal of the American Chemical Society. 130: 11562-11562. DOI: 10.1021/Ja8031345 |
0.321 |
|
| 2008 |
Williams RM, Burnett CM. Chapter 8 Diphenyloxazinones: versatile templates for the asymmetric synthesis of α-amino acid, peptide isosteres, and natural products Strategies and Tactics in Organic Synthesis. 7: 268-327. DOI: 10.1016/S1874-6004(08)80012-3 |
0.686 |
|
| 2007 |
Vincent G, Lane JW, Williams RM. Regioselectivity of Pictet-Spengler Cyclization Reactions to Construct the Pentacyclic Frameworks of the Ecteinascidin-Saframycin Class of Tetrahydroisoquinoline Antitumor Antibiotics. Tetrahedron Letters. 48: 3719-3722. PMID 19578531 DOI: 10.1016/J.Tetlet.2007.03.113 |
0.468 |
|
| 2007 |
Greshock TJ, Grubbs AW, Williams RM. Concise, Biomimetic Total Synthesis of d,l-Marcfortine C. Tetrahedron. 63: 6124-6130. PMID 18596842 DOI: 10.1016/J.Tet.2007.03.016 |
0.534 |
|
| 2007 |
Jones DT, Artman GD, Williams RM. Coupling of activated esters to gramines in the presence of ethyl propiolate under mild conditions. Tetrahedron Letters. 48: 1291-1294. PMID 18438458 DOI: 10.1016/J.Tetlet.2006.12.016 |
0.462 |
|
| 2007 |
Namiki H, Chamberland S, Gubler DA, Williams RM. Synthetic and biosynthetic studies on FR900482 and mitomycin C: an efficient and stereoselective hydroxymethylation of an advanced benzazocane intermediate. Organic Letters. 9: 5341-4. PMID 18047354 DOI: 10.1021/Ol701960V |
0.807 |
|
| 2007 |
Hare S, Fischer W, Williams R, Terradot L, Bayliss R, Haas R, Waksman G. Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase. The Embo Journal. 26: 4926-34. PMID 17972918 DOI: 10.1038/Sj.Emboj.7601904 |
0.334 |
|
| 2007 |
Greshock TJ, Williams RM. Improved biomimetic total synthesis of D,L-stephacidin A. Organic Letters. 9: 4255-8. PMID 17854197 DOI: 10.1021/Ol701845T |
0.425 |
|
| 2007 |
Subramanian V, Ducept P, Williams RM, Luger K. Effects of photochemically activated alkylating agents of the FR900482 family on chromatin. Chemistry & Biology. 14: 553-63. PMID 17524986 DOI: 10.1016/J.Chembiol.2007.04.004 |
0.426 |
|
| 2007 |
Artman GD, Grubbs AW, Williams RM. Concise, asymmetric, stereocontrolled total synthesis of stephacidins A, B and notoamide B. Journal of the American Chemical Society. 129: 6336-42. PMID 17455936 DOI: 10.1021/Ja070259I |
0.542 |
|
| 2007 |
Vincent G, Williams RM. Asymmetric total synthesis of (-)-cribrostatin 4 (renieramycin H). Angewandte Chemie (International Ed. in English). 46: 1517-20. PMID 17387658 DOI: 10.1002/Anie.200604126 |
0.457 |
|
| 2007 |
Kato H, Yoshida T, Tokue T, Nojiri Y, Hirota H, Ohta T, Williams RM, Tsukamoto S. Notoamides A-D: prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp. Angewandte Chemie (International Ed. in English). 46: 2254-6. PMID 17304611 DOI: 10.1002/Anie.200604381 |
0.427 |
|
| 2007 |
Greshock TJ, Grubbs AW, Tsukamoto S, Williams RM. A concise, biomimetic total synthesis of stephacidin A and notoamide B. Angewandte Chemie (International Ed. in English). 46: 2262-5. PMID 17304610 DOI: 10.1002/Anie.200604378 |
0.477 |
|
| 2007 |
Grubbs AW, Artman GD, Tsukamoto S, Williams RM. A concise total synthesis of the notoamides C and D. Angewandte Chemie (International Ed. in English). 46: 2257-61. PMID 17304609 DOI: 10.1002/Anie.200604377 |
0.456 |
|
| 2007 |
Ketchum RE, Horiguchi T, Qiu D, Williams RM, Croteau RB. Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway. Phytochemistry. 68: 335-41. PMID 17157336 DOI: 10.1016/J.Phytochem.2006.10.019 |
0.383 |
|
| 2007 |
Vincent G, Chen Y, Lane JW, Williams RM. Formation of the C3-C4 unsaturated framework of cribrostatin 4 via dead-mediated oxidation of an allylic tertiary amine Heterocycles. 72: 385-398. DOI: 10.3987/Com-06-S(K)25 |
0.733 |
|
| 2006 |
Chen S, Williams RM. Syntheses of Highly Functionalized δ,γ-Unsaturated-α-Amino Acids. Tetrahedron. 62: 11572-11579. PMID 18438461 DOI: 10.1016/J.Tet.2006.09.069 |
0.476 |
|
| 2006 |
Johns DM, Mori M, Williams RM. Synthetic studies on quinine: quinuclidine construction via a ketone enolate regio- and diastereoselective Pd-mediated allylic alkylation. Organic Letters. 8: 4051-4. PMID 16928071 DOI: 10.1021/Ol061524S |
0.498 |
|
| 2006 |
Fishlock D, Williams RM. Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine. Organic Letters. 8: 3299-301. PMID 16836390 DOI: 10.1021/Ol061192R |
0.511 |
|
| 2006 |
Lane JW, Estevez A, Mortara K, Callan O, Spencer JR, Williams RM. Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. Bioorganic & Medicinal Chemistry Letters. 16: 3180-3. PMID 16632360 DOI: 10.1016/J.Bmcl.2006.03.042 |
0.406 |
|
| 2006 |
Valente MWN, Williams RM. The concise and versatile synthesis of epimalbrancheamide and structurally related analogs Heterocycles. 70: 249-259. DOI: 10.3987/Com-06-S(W)15 |
0.363 |
|
| 2006 |
Ducept P, Gubler DA, Williams RM. Improved syntheses of the FR900482 and mitomycin benzazocine ring core via Mitsunobu cyclization Heterocycles. 67: 597-619. DOI: 10.3987/Com-05-S(T)18 |
0.815 |
|
| 2006 |
Williams R, Looper R, Runnegar M. Synthesis of Cylindrospermopsin Synfacts. 2006: 0981-0981. DOI: 10.1055/S-2006-949334 |
0.707 |
|
| 2006 |
Looper RE, Runnegar MTC, Williams RM. Syntheses of the cylindrospermopsin alkaloids Tetrahedron. 62: 4549-4562. DOI: 10.1016/J.Tet.2006.02.044 |
0.72 |
|
| 2006 |
Adams LA, Valente MWN, Williams RM. A concise synthesis of d,l-brevianamide B via a biomimetically-inspired IMDA construction Tetrahedron. 62: 5195-5200. DOI: 10.1016/J.Tet.2005.11.097 |
0.36 |
|
| 2005 |
Lane JW, Chen Y, Williams RM. Asymmetric total syntheses of (-)-jorumycin, (-)-renieramycin G, 3-epi-jorumycin, and 3-epi-renieramycin G. Journal of the American Chemical Society. 127: 12684-90. PMID 16144418 DOI: 10.1002/CHIN.200604202 |
0.757 |
|
| 2005 |
Suzuki T, Honda Y, Izawa K, Williams RM. Remarkable diastereomeric rearrangement of an alpha-acyloxy beta-ketosulfide to an alpha-acyloxy thioester: a novel approach to the synthesis of optically active (2S,3S) beta-amino alpha-hydroxy acids. The Journal of Organic Chemistry. 70: 7317-23. PMID 16122253 DOI: 10.1021/Jo0509915 |
0.476 |
|
| 2005 |
Looper RE, Runnegar MT, Williams RM. Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis. Angewandte Chemie (International Ed. in English). 44: 3879-81. PMID 15900531 DOI: 10.1002/Anie.200500520 |
0.712 |
|
| 2005 |
Grubbs AW, Artman GD, Williams RM. Concise syntheses of the 1,7-dihydropyrano[2,3-g]indole ring system of the stephacidins, aspergamides and norgeamides Tetrahedron Letters. 46: 9013-9016. DOI: 10.1016/J.Tetlet.2005.10.112 |
0.354 |
|
| 2005 |
Dastlik KA, Sundermeier U, Johns DM, Chen Y, Williams RM. An improved synthesis of optically pure 4-Boc-5,6-diphenylmorpholin-2-one and 4-Cbz-5,6-diphenylmorpholin-2-one Synlett. 693-696. DOI: 10.1002/CHIN.200532157 |
0.736 |
|
| 2004 |
Ahrendt KA, Williams RM. A concise asymmetric synthesis of the ADE fragment of nakadomarin A. Organic Letters. 6: 4539-41. PMID 15548070 DOI: 10.1021/Ol048126E |
0.45 |
|
| 2004 |
Looper RE, Williams RM. A concise asymmetric synthesis of the marine hepatotoxin 7-epicylindrospermopsin. Angewandte Chemie (International Ed. in English). 43: 2930-3. PMID 15170307 DOI: 10.1002/Anie.200454208 |
0.743 |
|
| 2004 |
Albrecht BK, Williams RM. A concise, total synthesis of the TMC-95A/B proteasome inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 101: 11949-54. PMID 15163792 DOI: 10.1073/Pnas.0308432101 |
0.745 |
|
| 2004 |
Jennewein S, Long RM, Williams RM, Croteau R. Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chemistry & Biology. 11: 379-87. PMID 15123267 DOI: 10.1016/J.Chembiol.2004.02.022 |
0.443 |
|
| 2004 |
Judd TC, Williams RM. A concise total synthesis of (+)-FR900482 and (+)-FR66979. The Journal of Organic Chemistry. 69: 2825-30. PMID 15074934 DOI: 10.1021/Jo035828T |
0.818 |
|
| 2004 |
Adams LA, Gray CR, Williams RM. Concise synthesis of the core bicyclo[2.2.2]diazaoctane ring common to asperparaline, paraherquamide, and stephacidin alkaloids Tetrahedron Letters. 45: 4489-4493. DOI: 10.1016/J.Tetlet.2004.04.054 |
0.433 |
|
| 2004 |
Judd TC, Williams RM. A Concise Total Synthesis of (+)-FR900482 (Ia) and (+)-FR66979 (Ib). Cheminform. 35. DOI: 10.1002/chin.200434229 |
0.773 |
|
| 2003 |
Williams RM, Ducept P. Interstrand cross-linking of DNA by FK317 and its deacetylated metabolites FR70496 and FR157471. Biochemistry. 42: 14696-701. PMID 14661983 DOI: 10.1021/Bi035202X |
0.44 |
|
| 2003 |
Gray CR, Sanz-Cervera JF, Silks LA, Williams RM. Studies on the biosynthesis of asperparaline A: origin of the spirosuccinimde ring system. Journal of the American Chemical Society. 125: 14692-3. PMID 14640629 DOI: 10.1021/Ja037687I |
0.477 |
|
| 2003 |
Williams RM, Cao J, Tsujishima H, Cox RJ. Asymmetric, stereocontrolled total synthesis of paraherquamide A. Journal of the American Chemical Society. 125: 12172-8. PMID 14519003 DOI: 10.1021/Ja036713+ |
0.652 |
|
| 2003 |
Aoyagi Y, Saitoh Y, Ueno T, Horiguchi M, Takeya K, Williams RM. Lipase TL-mediated kinetic tesolution of 5-benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol at low temperature: concise asymmetric synthesis of both enantiomers of a piperazic acid derivative. The Journal of Organic Chemistry. 68: 6899-904. PMID 12946129 DOI: 10.1021/Jo034441N |
0.456 |
|
| 2003 |
Onishi T, Sebahar PR, Williams RM. Concise, asymmetric total synthesis of spirotryprostatin A. Organic Letters. 5: 3135-7. PMID 12917000 DOI: 10.1021/Ol0351910 |
0.808 |
|
| 2003 |
Stocking EM, Williams RM. Chemistry and biology of biosynthetic Diels-Alder reactions. Angewandte Chemie (International Ed. in English). 42: 3078-115. PMID 12866094 DOI: 10.1002/Anie.200200534 |
0.472 |
|
| 2003 |
DeMong DE, Williams RM. Asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB. Journal of the American Chemical Society. 125: 8561-5. PMID 12848564 DOI: 10.1021/Ja0351241 |
0.795 |
|
| 2003 |
Jin W, Metobo S, Williams RM. Synthetic studies on ecteinascidin-743: constructing a versatile pentacyclic intermediate for the synthesis of ecteinascidins and saframycins. Organic Letters. 5: 2095-8. PMID 12790537 DOI: 10.1021/Ol034575N |
0.531 |
|
| 2003 |
Jennewein S, Rithner CD, Williams RM, Croteau R. Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase. Archives of Biochemistry and Biophysics. 413: 262-70. PMID 12729625 DOI: 10.1016/S0003-9861(03)00090-0 |
0.398 |
|
| 2003 |
Domingo LR, Zaragozá RJ, Williams RM. Studies on the biosynthesis of paraherquamide A and VM99955. A theoretical study of intramolecular Diels-Alder cycloaddition. The Journal of Organic Chemistry. 68: 2895-902. PMID 12662067 DOI: 10.1021/Jo020564G |
0.48 |
|
| 2003 |
Ketchum RE, Rithner CD, Qiu D, Kim YS, Williams RM, Croteau RB. Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry. 62: 901-9. PMID 12590117 DOI: 10.1016/S0031-9422(02)00711-2 |
0.401 |
|
| 2003 |
Williams RM, Cox RJ. Paraherquamides, brevianamides, and asperparalines: laboratory synthesis and biosynthesis. An interim report. Accounts of Chemical Research. 36: 127-39. PMID 12589698 DOI: 10.1021/Ar020229E |
0.531 |
|
| 2003 |
Albrecht BK, Williams RM. A concise formal total synthesis of TMC-95A/B proteasome inhibitors. Organic Letters. 5: 197-200. PMID 12529139 DOI: 10.1021/Ol0272545 |
0.743 |
|
| 2003 |
Jin W, Williams RM. Synthetic studies on ecteinascidin 743: asymmetric synthesis of the versatile amino acid component Tetrahedron Letters. 44: 4635-4639. DOI: 10.1016/S0040-4039(03)01082-7 |
0.416 |
|
| 2003 |
Williams RM, Sinclair PJ, DeMong DE. Efficient Asymmetric Synthesis of N‐tert‐Butoxycarbonyl α‐Aminoacids Using 4‐tert‐Butoxycarbonyl‐5,6‐Diphenylmorpholin‐2‐one: (R)‐(N‐tert‐Butoxycarbonyl)Allylglycine Organic Syntheses. 80: 31-37. DOI: 10.1002/0471264180.Os080.04 |
0.389 |
|
| 2003 |
Williams RM, Sinclair PJ, DeMong DE, Chen D, Zhai D. Asymmetric Synthesis of N‐tert‐Butoxycarbonyl α‐Amino Acids. Synthesis of (5S,6R)‐4‐tert‐Butoxycarbonyl‐5,6‐Diphenylmorpholin‐2‐one Organic Syntheses. 80: 18-30. DOI: 10.1002/0471264180.Os080.03 |
0.336 |
|
| 2003 |
Stille JK, Echavarren AM, Williams RM, Hendrix JA. 4‐Methoxy‐4′‐Nitrobiphenyl Organic Syntheses. 97-97. DOI: 10.1002/0471264180.Os071.13 |
0.343 |
|
| 2002 |
Judd TC, Williams RM. Concise enantioselective synthesis of (+)-FR66979 and (+)-FR900482: dimethyldioxirane-mediated construction of the hydroxylamine hemiketal. Angewandte Chemie (International Ed. in English). 41: 4683-5. PMID 12481325 DOI: 10.1002/Anie.200290015 |
0.801 |
|
| 2002 |
Judd TC, Williams RM. Synthesis and DNA cross-linking of a phototriggered FR900482 mitosene progenitor. Organic Letters. 4: 3711-4. PMID 12375925 DOI: 10.1021/Ol0266774 |
0.781 |
|
| 2002 |
Jain RP, Williams RM. Asymmetric synthesis of (+)-negamycin. The Journal of Organic Chemistry. 67: 6361-5. PMID 12201754 DOI: 10.1021/Jo025636I |
0.524 |
|
| 2002 |
Horiguchi T, Rithner CD, Croteau R, Williams RM. Studies on taxol biosynthesis. Preparation of taxa-4(20),11(12)-dien-5 alpha-acetoxy-10 beta-ol by deoxygenation of a taxadiene tetraacetate obtained from Japanese yew. The Journal of Organic Chemistry. 67: 4901-3. PMID 12098303 DOI: 10.1021/Jo025679Z |
0.446 |
|
| 2002 |
Williams RM. Total synthesis and biosynthesis of the paraherquamides: An intriguing story of the biological Diels-Alder construction Chemical and Pharmaceutical Bulletin. 50: 711-740. PMID 12045324 DOI: 10.1248/Cpb.50.711 |
0.494 |
|
| 2002 |
Scott JD, Williams RM. Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics. Chemical Reviews. 102: 1669-730. PMID 11996547 DOI: 10.1021/Cr010212U |
0.639 |
|
| 2002 |
Beckerbauer L, Tepe JJ, Eastman RA, Mixter PF, Williams RM, Reeves R. Differential effects of FR900482 and FK317 on apoptosis, IL-2 gene expression, and induction of vascular leak syndrome. Chemistry & Biology. 9: 427-41. PMID 11983332 DOI: 10.1016/S1074-5521(02)00122-9 |
0.624 |
|
| 2002 |
Scott JD, Williams RM. Total synthesis of (-)-tetrazomine. Determination of the stereochemistry of tetrazomine and the synthesis and biological activity of tetrazomine analogues. Journal of the American Chemical Society. 124: 2951-6. PMID 11902886 DOI: 10.1021/Ja0174027 |
0.731 |
|
| 2002 |
Sanz-Cervera JF, Williams RM. Asymmetric total synthesis of (-)-VM55599: establishment of the absolute stereochemistry and biogenetic implications. Journal of the American Chemical Society. 124: 2556-9. PMID 11890806 DOI: 10.1021/Ja017425L |
0.54 |
|
| 2002 |
Aoyagi Y, Iijima A, Williams RM. Asymmetric synthesis of [2,3-(13)C(2),(15)N]-4-benzyloxy-5,6-diphenyl-2,3,5,6-tetrahydro-4H-oxazine-2-one via lipase TL-mediated kinetic resolution of benzoin: general procedure for the synthesis of [2,3-(13)C(2),(15)N]-L-alanine. The Journal of Organic Chemistry. 66: 8010-4. PMID 11722198 DOI: 10.1021/Jo015725F |
0.326 |
|
| 2002 |
Sebahar PR, Williams RM. The Synthesis of Spirooxindole Pyrrolidines via an Asymmetric Azomethine Ylide [1,3]-Dipolar Cycloaddition Reaction Heterocycles. 58: 563-575. DOI: 10.3987/Com-02-S(M)51 |
0.791 |
|
| 2002 |
DeMong DE, Williams RM. The first asymmetric synthesis of (2S)- and (2R)-amino-3,3-dimethoxypropanoic acid Tetrahedron Letters. 43: 2355-2357. DOI: 10.1016/S0040-4039(02)00269-1 |
0.769 |
|
| 2002 |
Cox RJ, Williams RM. Synthetic studies towards paraherquamide F: Synthesis of the 1,7-dihydropyrano[2,3-g]indole ring system Tetrahedron Letters. 43: 2149-2152. DOI: 10.1016/S0040-4039(02)00220-4 |
0.318 |
|
| 2002 |
Sebahar PR, Osada H, Usui T, Williams RM. Asymmetric, stereocontrolled total synthesis of (+) and (-)-spirotryprostatin B via a diastereoselective azomethine ylide [1,3]-dipolar cycloaddition reaction Tetrahedron. 58: 6311-6322. DOI: 10.1016/S0040-4020(02)00630-0 |
0.791 |
|
| 2002 |
Tepe JJ, Kosogof C, Williams RM. DNA interstrand cross-link formation by reductive activation of dehydropyrrolizidine progenitors Tetrahedron. 58: 3553-3559. DOI: 10.1016/S0040-4020(02)00311-3 |
0.611 |
|
| 2001 |
Scott JD, Williams RM. Total Synthesis of (-)-Tetrazomine and Determination of Its Stereochemistry. Angewandte Chemie (International Ed. in English). 40: 1463-1465. PMID 29712345 DOI: 10.1002/1521-3773(20010417)40:8<1463::Aid-Anie1463>3.0.Co;2-8 |
0.726 |
|
| 2001 |
Jain RP, Albrecht BK, DeMong DE, Williams RM. Asymmetric synthesis of (+)-hypusine. Organic Letters. 3: 4287-9. PMID 11784199 DOI: 10.1021/Ol016959O |
0.806 |
|
| 2001 |
Aoyagi Y, Jain RP, Williams RM. Stereocontrolled asymmetric synthesis of alpha-hydroxy-beta-amino acids. A stereodivergent approach. Journal of the American Chemical Society. 123: 3472-7. PMID 11472118 DOI: 10.1021/Ja0042332 |
0.316 |
|
| 2001 |
Wheeler AL, Long RM, Ketchum RE, Rithner CD, Williams RM, Croteau R. Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells. Archives of Biochemistry and Biophysics. 390: 265-78. PMID 11396929 DOI: 10.1006/Abbi.2001.2377 |
0.322 |
|
| 2001 |
Scott JD, Williams RM. Total Synthesis of (-)-Tetrazomine and Determination of Its Stereochemistry This work was supported by the National Institutes of Health (Grant CA85419). We are grateful to Yamanouchi Pharmaceutical Co. for providing a generous gift of natural tetrazomine. Angewandte Chemie (International Ed. in English). 40: 1463-1465. PMID 11317303 DOI: 10.1002/1521-3773(20010417)40:8<1463::AID-ANIE1463>3.0.CO;2-8 |
0.626 |
|
| 2001 |
Stocking EM, Sanz-Cervera JF, Williams RM. Studies on the Biosynthesis of Paraherquamide: Synthesis and Incorporation of a Hexacyclic Indole Derivative as an Advanced Metabolite This work was supported by the National Institutes of Health (Grant no. CA70375 to R.M.W.). We wish to acknowledge the American Chemical Society Division of Organic Chemistry Fellowship (sponsored by SmithKline Beecham) and the Pharmacia-Upjohn Company for financial support (to E.M.S.). Mass spectra were obtained on instruments supported by the National Institutes of Health Shared Instrumentation Grant (No. GM49631). We also wish to thank Professor Dean Crick of the Department of Microbiology at Colorado State University for helpful discussions. J.F.S.-C. thanks the DGICYT of Spain for a research grant (project no. PB98-1438). Angewandte Chemie (International Ed. in English). 40: 1296-1298. PMID 11301457 DOI: 10.1002/1521-3773(20010401)40:7<1296::Aid-Anie1296>3.0.Co;2-G |
0.403 |
|
| 2001 |
Schoendorf A, Rithner CD, Williams RM, Croteau RB. Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast. Proceedings of the National Academy of Sciences of the United States of America. 98: 1501-6. PMID 11171980 DOI: 10.1073/Pnas.98.4.1501 |
0.302 |
|
| 2001 |
Beckerbauer L, Tepe JJ, Cullison J, Reeves R, Williams RM. FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo. Chemistry & Biology. 7: 805-12. PMID 11033083 DOI: 10.1016/S1074-5521(00)00028-4 |
0.591 |
|
| 2001 |
Kosogof C, Tepe JJ, Williams RM. DNA cross-linking by a phototriggered pyrrolic progenitor developed from monocrotaline Tetrahedron Letters. 42: 6641-6643. DOI: 10.1016/S0040-4039(01)01341-7 |
0.62 |
|
| 2001 |
Jain RP, Williams RM. Asymmetric synthesis of (R)-(−)-carnitine Tetrahedron Letters. 42: 4437-4440. DOI: 10.1016/S0040-4039(01)00780-8 |
0.373 |
|
| 2001 |
DeMong DE, Williams RM. The asymmetric synthesis of (2S,3R)-capreomycidine Tetrahedron Letters. 42: 3529-3532. DOI: 10.1016/S0040-4039(01)00487-7 |
0.781 |
|
| 2001 |
Albrecht BK, Williams RM. Entry into the bi-aryl moiety of the TMC-95 proteasome inhibitors via the Stille protocol Tetrahedron Letters. 42: 2755-2757. DOI: 10.1016/S0040-4039(01)00299-4 |
0.727 |
|
| 2001 |
Herberich B, Kinugawa M, Vazquez A, Williams RM. Sequential Staudinger/Pictet–Spengler cyclization strategy for the construction of tetrahydroisoquinolines of the bioxalomycin and ecteinascidin family of alkaloids Tetrahedron Letters. 42: 543-546. DOI: 10.1016/S0040-4039(00)02015-3 |
0.33 |
|
| 2001 |
DeMong DE, Williams RM. An efficient asymmetric synthesis of (2S,3S)- and (2R,3R)-β-hydroxyornithine Tetrahedron Letters. 42: 183-185. DOI: 10.1016/S0040-4039(00)01945-6 |
0.762 |
|
| 2001 |
Looper RE, Williams RM. Construction of the A-ring of cylindrospermopsin via an intramolecular oxazinone-N-oxide dipolar cycloaddition Tetrahedron Letters. 42: 769-771. DOI: 10.1016/S0040-4039(00)01921-3 |
0.686 |
|
| 2001 |
Jain RP, Williams RM. Asymmetric synthesis of (S)-(+)-carnitine and analogs Tetrahedron. 57: 6505-6509. DOI: 10.1016/S0040-4020(01)00542-7 |
0.379 |
|
| 2000 |
Williams DC, Carroll BJ, Jin Q, Rithner CD, Lenger SR, Floss HG, Coates RM, Williams RM, Croteau R. Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chemistry & Biology. 7: 969-77. PMID 11137819 DOI: 10.1016/S1074-5521(00)00046-6 |
0.8 |
|
| 2000 |
and AV, Williams RM. Studies on the Biosynthesis of Taxol. Synthesis of Taxa-4(20),11(12)-diene-2α,5α-diol Journal of Organic Chemistry. 65: 7865-7869. PMID 11073592 DOI: 10.1021/Jo005537+ |
0.331 |
|
| 2000 |
Williams RM, Cao J, Tsujishima H. Asymmetric, Stereocontrolled Total Synthesis of Paraherquamide A This work was supported by the NIH (Grant CA 70375). The Japanese Society for the Promotion of Science (JSPS) is acknowledged for providing support to H.T. Mass spectra were obtained on instruments supported by the NIH Shared Instrumentation Grant (GM 49631). We also wish to thank Dr. Timothy Blizzard (Merck & Co.) for providing an authentic sample of natural paraherquamide A. We also wish to acknowledge Dr. Byung H. Lee (Pharmacia-Upjohn Co.) for providing NMR spectra and an authentic specimen of 14-oxoparaherquamide B. We also wish to thank Dr. Alfredo Vazquez for assistance with purification and characterization of synthetic paraherquamide A. Angewandte Chemie (International Ed. in English). 39: 2540-2544. PMID 10941129 DOI: 10.1002/1521-3773(20000717)39:14<2540::Aid-Anie2540>3.0.Co;2-R |
0.486 |
|
| 2000 |
Herberich B, Scott JD, Williams RM. Synthesis of a netropsin conjugate of a water-soluble epi-quinocarcin analogue: the importance of stereochemistry at nitrogen. Bioorganic & Medicinal Chemistry. 8: 523-32. PMID 10732968 DOI: 10.1016/S0968-0896(99)00314-4 |
0.644 |
|
| 2000 |
Bender DM, Hennings DD, Williams RM. A Synthesis of 5′-Amino-3′,5′-dideoxyuridine Synthesis. 2000: 399-402. DOI: 10.1055/S-2000-6346 |
0.359 |
|
| 2000 |
Stocking EM, Sanz-Cervera JF, Williams RM. Total Synthesis of VM55599. Utilization of an Intramolecular Diels−Alder Cycloaddition of Potential Biogenetic Relevance Journal of the American Chemical Society. 122: 1675-1683. DOI: 10.1021/Ja993791H |
0.427 |
|
| 2000 |
Sebahar PR, Williams RM. The asymmetric total synthesis of (+)- and (-)-spirotryprostatin B [16] Journal of the American Chemical Society. 122: 5666-5667. DOI: 10.1021/Ja001133N |
0.77 |
|
| 2000 |
Scott JD, Williams RM. Synthetic studies on tetrazomine: lipase PS resolution of racemic cis-β-hydroxypipecolic acid Tetrahedron Letters. 41: 8413-8416. DOI: 10.1016/S0040-4039(00)01527-6 |
0.617 |
|
| 2000 |
Williams RM, Rollins SB, Judd TC. Synthesis of the First Photo-Triggered Pro-mitosene Based on FR-900482 Tetrahedron. 56: 521-532. DOI: 10.1016/S0040-4020(99)01046-7 |
0.793 |
|
| 1999 |
Stocking EM, Sanz-Cervera JF, Williams RM. Reverse versus Normal Prenyl Transferases in Paraherquamide Biosynthesis Exhibit Distinct Facial Selectivities. Angewandte Chemie (International Ed. in English). 38: 786-789. PMID 29711799 DOI: 10.1002/(Sici)1521-3773(19990315)38:6<786::Aid-Anie786>3.0.Co;2-7 |
0.418 |
|
| 1999 |
Williams RM. Asymmetric syntheses of unnatural amino acids and hydroxyethylene Peptide isosteres. Methods in Molecular Medicine. 23: 339-356. PMID 21380906 DOI: 10.1385/0-89603-517-4:339 |
0.35 |
|
| 1999 |
Tepe JJ, Williams RM. Reductive Activation of a Hydroxylamine Hemiacetal Derivative of Dehydromonocrotaline: The First Reductively Activated Pyrrolizidine Alkaloid Capable of Cross-Linking DNA. Angewandte Chemie. 38: 3501-3503. PMID 10602221 DOI: 10.1002/(Sici)1521-3773(19991203)38:23<3501::Aid-Anie3501>3.0.Co;2-W |
0.604 |
|
| 1999 |
Tepe JJ, Williams RM. DNA Cross-Linking by a Phototriggered Dehydromonocrotaline Progenitor Journal of the American Chemical Society. 121: 2951-2955. DOI: 10.1021/Ja983894K |
0.61 |
|
| 1999 |
Gonzalez F, Sanz-Cervera JF, Williams RM. Synthetic studies on asperparaline A.Synthesis of the spirosuccinimide ring system Tetrahedron Letters. 40: 4519-4522. DOI: 10.1016/S0040-4039(99)00825-4 |
0.389 |
|
| 1999 |
Tepe J, Williams R. Reduktive Aktivierung eines Hydroxylamin-Hemiacetal-Derivats von Dehydromonocrotalin: das erste reduktiv aktivierbare Pyrrolizidinalkaloid, das DNA-Stränge quervernetzen kann Angewandte Chemie. 111: 3711-3713. DOI: 10.1002/(Sici)1521-3757(19991203)111:23<3711::Aid-Ange3711>3.0.Co;2-A |
0.558 |
|
| 1998 |
Rajski SR, Williams RM. DNA Cross-Linking Agents as Antitumor Drugs. Chemical Reviews. 98: 2723-2796. PMID 11848977 DOI: 10.1021/Cr9800199 |
0.376 |
|
| 1998 |
Williams RM, Sanz-Cervera JF, Sancenón F, Marco JA, Halligan KM. Biomimetic Diels-Alder cyclizations for the construction of the brevianamide, paraherquamide, sclerotamide, asperparaline and VM55599 ring systems. Bioorganic & Medicinal Chemistry. 6: 1233-41. PMID 9784865 DOI: 10.1016/S0968-0896(98)00102-3 |
0.799 |
|
| 1998 |
Hecker SJ, Cho IS, Glinka TW, Zhang ZJ, Price ME, Lee VJ, Christensen BG, Boggs A, Chamberland S, Malouin F, Parr TR, Annamalai T, Blais J, Bond EL, Case L, ... ... Williams R, et al. Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant Staphylococcus aureus. The Journal of Antibiotics. 51: 722-34. PMID 9766464 DOI: 10.7164/Antibiotics.51.722 |
0.577 |
|
| 1998 |
Williams RM, Yuan C, Lee VJ, Chamberland S. Synthesis and antimicrobial evaluation of TAN-1057A/B analogs. The Journal of Antibiotics. 51: 189-201. PMID 9544941 DOI: 10.7164/Antibiotics.51.189 |
0.591 |
|
| 1998 |
Aoyagi Y, Williams RM. Efficient Asymmetric Synthesis of (S)-2-Methylasparagine Synlett. 1998: 1099-1101. DOI: 10.1055/S-1998-1884 |
0.363 |
|
| 1998 |
Williams RM, Liu J. Asymmetric Synthesis Of Differentially Protected 2,7-Diaminosuberic Acid, A Ring-Closure Metathesis Approach Journal of Organic Chemistry. 63: 2130-2132. DOI: 10.1021/Jo971575Q |
0.425 |
|
| 1998 |
Williams RM, Sanz-Cervera JF, Sancenón F, Marco JA, Halligan K. Biomimetic Diels−Alder Cyclizations for the Construction of the Brevianamide, Paraherquamide Sclerotamide, and VM55599 Ring Systems Journal of the American Chemical Society. 120: 1090-1091. DOI: 10.1021/Ja972998C |
0.777 |
|
| 1998 |
Scott JD, Tippie TN, Williams RM. Synthetic studies on tetrazomine: Stereochemical assignment of the β-hydroxypipecolic acid Tetrahedron Letters. 39: 3659-3662. DOI: 10.1016/S0040-4039(98)00642-X |
0.609 |
|
| 1998 |
Aoyagi Y, Williams RM. Asymmetric synthesis of 1-Boc-3- and 4-hydroxypyrrolidines Tetrahedron. 54: 13045-13058. DOI: 10.1016/S0040-4020(98)00807-2 |
0.304 |
|
| 1998 |
Aoyagi Y, Williams RM. General asymmetric synthesis of hydroxymethylene and hydroxyethylene peptide isosteres Tetrahedron. 54: 10419-10433. DOI: 10.1016/S0040-4020(98)00495-5 |
0.34 |
|
| 1997 |
Bender DM, Williams RM. An efficient synthesis of (S)-m-tyrosine Journal of Organic Chemistry. 62: 6690-6691. DOI: 10.1021/Jo9706584 |
0.303 |
|
| 1997 |
Yuan C, Williams RM. Total Synthesis Of The Anti Methicillin-Resistant Staphylococcus Aureus Peptide Antibiotics Tan-1057A-D Journal of the American Chemical Society. 119: 11777-11784. DOI: 10.1021/Ja972670J |
0.31 |
|
| 1997 |
Rollins SB, Williams RM. Synthetic studies on FR 900482. Synthesis of a photo-triggered pro-mitosene Tetrahedron Letters. 38: 4033-4036. DOI: 10.1016/S0040-4039(97)00865-4 |
0.434 |
|
| 1996 |
Hefner J, Rubenstein SM, Ketchum RE, Gibson DM, Williams RM, Croteau R. Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chemistry & Biology. 3: 479-89. PMID 8807878 DOI: 10.1016/S1074-5521(96)90096-4 |
0.333 |
|
| 1996 |
Stocking EM, Sanz-Cervera JF, Williams RM, Unkefer CJ. Studies on the Biosynthesis of Paraherquamide A. Origin of the β-Methylproline Ring Journal of the American Chemical Society. 118: 7008-7009. DOI: 10.1021/Ja961322Z |
0.344 |
|
| 1996 |
Williams RM, Cao J. Studies on the total synthesis of paraherquamide A. Stereocontrolled, asymmetric synthesis of α-alkyl-β-hydroxyproline derivatives Tetrahedron Letters. 37: 5441-5444. DOI: 10.1016/0040-4039(96)01189-6 |
0.536 |
|
| 1996 |
Yuan C, Williams RM. An efficient method for the preparation of amidinoureas Tetrahedron Letters. 37: 1945-1948. DOI: 10.1016/0040-4039(96)00175-X |
0.338 |
|
| 1995 |
Rubenstein SM, Williams RM. Studies on the Biosynthesis of Taxol: Total Synthesis of Taxa-4(20),11(12)-diene and Taxa-4(5),11(12)-diene. The First Committed Biosynthetic Intermediate Journal of Organic Chemistry. 60: 7215-7223. DOI: 10.1021/Jo00127A029 |
0.441 |
|
| 1995 |
Flanagan ME, Williams RM. Synthetic Studies on Quinocarcin: Total Synthesis of (.+-.)-Quinocarcinamide via Dipole Cycloaddition of an Azomethine Ylide Generated by NBS Oxidation The Journal of Organic Chemistry. 60: 6791-6797. DOI: 10.1021/Jo00126A031 |
0.347 |
|
| 1994 |
Williams RM, Colson P, Zhai W. A new method for hydroxymethylene peptide isostere synthesis: Asymmetric synthesis of statine Tetrahedron Letters. 35: 9371-9374. DOI: 10.1016/S0040-4039(00)78545-5 |
0.417 |
|
| 1993 |
Williams RM, Fegley GJ. Asymmetric synthesis of (1S,2R)-(+)-2-phenyl-1-aminocyclopropane-1-carboxylic acid Journal of Organic Chemistry. 58: 6933-6935. DOI: 10.1021/Jo00076A077 |
0.339 |
|
| 1993 |
Cushing TD, Sanz-Cervera JF, Williams RM. Stereocontrolled Total Synthesis of (+)-Paraherquamide B⊥ Journal of the American Chemical Society. 115: 9323-9324. DOI: 10.1021/Ja952666C |
0.416 |
|
| 1993 |
Miknis GF, Williams RM. Total synthesis of (.+-.)-aspirochlorine Journal of the American Chemical Society. 115: 536-547. DOI: 10.1021/Ja00055A025 |
0.411 |
|
| 1993 |
Sanz-Cervera JF, Glinka T, Williams RM. Biosynthesis of the brevianamides: quest for a biosynthetic Diels-Alder cyclization Journal of the American Chemical Society. 115: 347-348. DOI: 10.1021/Ja00054A051 |
0.417 |
|
| 1992 |
Williams RM, Zhai W, Aldous DJ, Aldous SC. Asymmetric [1,3]-dipolar cycloaddition reactions: synthesis of highly substituted proline derivatives Journal of Organic Chemistry. 57: 6527-6532. DOI: 10.1021/Jo00050A029 |
0.41 |
|
| 1992 |
Williams RM, Hendrix JA. Asymmetric synthesis of arylglycines Chemical Reviews. 92: 889-917. DOI: 10.1021/Cr00013A007 |
0.364 |
|
| 1992 |
Williams RM, Fegley GJ. Asymmetric synthesis of S-(−)-cucurbitine Tetrahedron Letters. 33: 6755-6758. DOI: 10.1016/S0040-4039(00)61768-9 |
0.371 |
|
| 1991 |
Williams RM, Fegley GJ. Asymmetric syntheses of 1-aminocyclopropane-1-carboxylic acid derivatives Journal of the American Chemical Society. 113: 8796-8806. DOI: 10.1021/Ja00023A030 |
0.328 |
|
| 1991 |
Williams RM, Im MN, Cao J. Asymmetric synthesis of 2,6-diamino-6-(hydroxymethyl)pimelic acid: assignment of stereochemistry Journal of the American Chemical Society. 113: 6976-6981. DOI: 10.1021/Ja00018A040 |
0.553 |
|
| 1991 |
Williams RM, Sabol MR, Kim HD, Kwast A. Novel ring contractions via [2,3] Wittig type rearrangements: synthesis of 2-desoxy-2-methylenebicyclomycin Journal of the American Chemical Society. 113: 6621-6633. DOI: 10.1021/Ja00017A039 |
0.373 |
|
| 1991 |
Williams RM, Esslinger CS. Synthesis of tri-substituted furans: mild Ti(IV)-mediated couplings to acetals. Construction of the epoxy hemi-amido ketal of fusarin C Tetrahedron Letters. 32: 3635-3638. DOI: 10.1016/S0040-4039(00)79753-X |
0.36 |
|
| 1991 |
Williams RM, Glinka T, Gallegos R, Ehrlich PP, Flanagan ME, Coffman H, Park G. Synthesis, conformation, crystal structures and DNA cleavage abilities of tetracyclic analogs of quinocarcin Tetrahedron. 47: 2629-2642. DOI: 10.1016/S0040-4020(01)81795-6 |
0.328 |
|
| 1990 |
Williams RM, Aldous DJ, Aldous SC. Synthesis of ethynylglycine (FR-900130) Journal of the Chemical Society, Perkin Transactions 1. 171-172. DOI: 10.1039/P19900000171 |
0.343 |
|
| 1990 |
Williams RM, Glinka T, Kwast E, Coffman H, Stille JK. Asymmetric, stereocontrolled total synthesis of (-)-brevianamide B Journal of the American Chemical Society. 112: 808-821. DOI: 10.1021/Ja00158A048 |
0.408 |
|
| 1990 |
Williams RM, Milreis GF. Synthetic studies on aspirochlorine (A30641) Tetrahedron Letters. 31: 4297-4300. DOI: 10.1016/S0040-4039(00)97605-6 |
0.34 |
|
| 1990 |
Williams RM, Cushing TD. Synthetic studies on paraherquamide: synthesis of the 2H-1,5. Benzodioxepin ring system Tetrahedron Letters. 31: 6325-6328. DOI: 10.1016/S0040-4039(00)97054-0 |
0.365 |
|
| 1989 |
Williams RM, Glinka T, Kwast E. Synthetic studies on paraherquamide: Regioselectivity of indole oxidation Tetrahedron Letters. 30: 5575-5578. DOI: 10.1016/S0040-4039(01)93803-1 |
0.335 |
|
| 1989 |
Yasuda N, Williams RM. Synthetic studies of FR900482: Promising method to construct the bicyclic hydroxylamine hemi-ketal ring system Tetrahedron Letters. 30: 3397-3400. DOI: 10.1016/S0040-4039(00)99254-2 |
0.375 |
|
| 1988 |
Williams RM, Brunner EJ, Sabol MR. Synthesis of Verruculotoxin Synthesis. 1988: 963-966. DOI: 10.1055/S-1988-27767 |
0.311 |
|
| 1988 |
Williams RM, Glinka T, Kwast E. Facial selectivity of the intramolecular SN2' cyclization: stereocontrolled total synthesis of brevianamide B Journal of the American Chemical Society. 110: 5927-5929. DOI: 10.1021/Ja00225A069 |
0.349 |
|
| 1988 |
Williams RM, Sinclair PJ, Zhai W. Asymmetric synthesis of .beta.-carboxyaspartic acid Journal of the American Chemical Society. 110: 482-483. DOI: 10.1021/Ja00210A027 |
0.312 |
|
| 1988 |
Williams RM, Durham CA. Bicyclomycin: synthetic, mechanistic, and biological studies Chemical Reviews. 88: 511-540. DOI: 10.1021/Cr00085A004 |
0.312 |
|
| 1988 |
Williams RM, Im MN. Asymmetric synthesis of α-amino acids: Comparison of enolate vs. cation functionalization of N-BOC-5, 6-diphenyl-2,3,5,6-tetrahydro-4h-1,4-oxazin-2-ones Tetrahedron Letters. 29: 6075-6078. DOI: 10.1016/S0040-4039(00)82268-6 |
0.347 |
|
| 1986 |
Williams RM, Zhai D, Sinclair PJ. Asymmetric synthesis of (R)- and (S)-[2-2H1]glycine The Journal of Organic Chemistry. 51: 5021-5022. DOI: 10.1021/Jo00375A055 |
0.303 |
|
| 1986 |
Sinclair PJ, Zhai D, Reibenspies J, Williams RM. Electrophilic glycinates: new and versatile templates for asymmetric amino acid synthesis Journal of the American Chemical Society. 108: 1103-1104. DOI: 10.1021/Ja00265A053 |
0.353 |
|
| 1986 |
Williams RM, Glinka T. Promising cyclization reactions to construct the ring systems of brevianamides A,B Tetrahedron Letters. 27: 3581-3584. DOI: 10.1016/S0040-4039(00)84854-6 |
0.372 |
|
| 1986 |
SINCLAIR PJ, ZHAI D, REIBENSPIES J, WILLIAMS RM. ChemInform Abstract: Electrophilic Glycinates: New and Versatile Templates for Asymmetric Amino Acid Synthesis. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198626292 |
0.351 |
|
| 1985 |
Williams RM, Armstrong RW, Dung JS. Synthesis and antimicrobial evaluation of bicyclomycin analogues. Journal of Medicinal Chemistry. 28: 733-40. PMID 4009595 DOI: 10.1021/Jm00383A008 |
0.33 |
|
| 1985 |
Williams RM, Armstrong RW, Dung JS. Stereocontrolled total synthesis of (.+-.)- and (+)-bicyclomycin Journal of the American Chemical Society. 107: 3253-3266. DOI: 10.1021/Ja00297A035 |
0.411 |
|
| 1985 |
Williams RM, Tomizawa K, Armstrong RW, Dung JS. Thiolate additions to bicyclomycin and analogues: a structurally novel latent Michael-acceptor system Journal of the American Chemical Society. 107: 6419-6421. DOI: 10.1002/Chin.198607331 |
0.324 |
|
| 1985 |
Williams RM, Armstrong RW, Maruyama LK, Dung JS, Anderson OP. Divergent, generalized synthesis of unsymmetrically substituted 2,5-piperazinediones Journal of the American Chemical Society. 107: 3246-3253. DOI: 10.1002/Chin.198538239 |
0.397 |
|
| 1985 |
STEWART AO, WILLIAMS RM. ChemInform Abstract: ALTERNATIVE PREPARATION OF METHYL 3-AMINO-2,3,6-TRIDEOXY-α-D-ARABINO-HEXOPYRANOSIDE AND CHIRAL INTERMEDIATES FOR THE SYNTHESIS OF THIENAMYCIN Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198523331 |
0.357 |
|
| 1984 |
Stewart AO, Williams RM. Alternative preparation of methyl 3-amino-2,3,6-trideoxy-α-d-arabino-hexopyranoside and chiral intermediates for the synthesis of thienamycin Carbohydrate Research. 135: 167-173. PMID 6525609 DOI: 10.1016/0008-6215(84)85014-4 |
0.354 |
|
| 1984 |
Williams RM, Armstrong RW, Dung JS. Stereocontrolled total synthesis of (.+-.)- and (+)-bicyclomycin: new carbon-carbon bond-forming reactions on electrophilic glycine anhydride derivatives Journal of the American Chemical Society. 106: 5748-5750. DOI: 10.1002/Chin.198502365 |
0.31 |
|
| 1983 |
Dung JS, Armstrong RW, Anderson OP, Williams RM. Improved synthesis and absolute configuration of (+)- and (-)-2,2,4-trimethyl-1,3-dioxolane-4-carboxaldehyde The Journal of Organic Chemistry. 48: 3592-3594. DOI: 10.1021/Jo00168A056 |
0.385 |
|
| 1982 |
Williams RM, Anderson OP, Armstrong R, Josey J, Meyers H, Eriksson C. A new and efficient cyclization reaction to construct the bicyclomycin ring system: synthesis of N,N'-dimethyl-4-desmethylenebicyclomycin Journal of the American Chemical Society. 104: 6092-6099. DOI: 10.1021/Ja00386A041 |
0.356 |
|
| 1981 |
Williams RM. Bicyclomycin synthetic studies: utilization of bridgehead carbanions Tetrahedron Letters. 22: 2341-2344. DOI: 10.1016/S0040-4039(01)82901-4 |
0.374 |
|
| 1980 |
Williams RM, William HR. Syntheses of the fungal metabolites (.+-.)-gliovictin and (.+-.)-hyalodendrin Journal of Organic Chemistry. 11: 2625-2631. DOI: 10.1021/Jo01301A017 |
0.316 |
|
| 1979 |
WILLIAMS RM, RASTETTER WH. ChemInform Abstract: AN EFFICIENT SYNTHESIS OF D,L-GLIOVICTIN: CONSTRUCTION OF THE HYDROXYMETHYL MOIETY VIA A 3-FORMYL-2,5-PIPERAZINEDIONE Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197927359 |
0.637 |
|
| 1974 |
Yoshida T, Williams RM, Negishi E. Stereoselective synthesis of partially substituted 1,2,3-butatriene derivatives via hydroboration Journal of the American Chemical Society. 96: 3688-3690. DOI: 10.1021/Ja00818A073 |
0.43 |
|
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