| Year |
Citation |
Score |
| 2024 |
Schnicker NJ, Xu Z, Amir M, Gakhar L, Huang CL. Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy. Biorxiv : the Preprint Server For Biology. PMID 38496408 DOI: 10.1101/2024.03.02.583144 |
0.532 |
|
| 2020 |
Huang CL, Jian X, Yuh CH. WNK1-OSR1/SPAK KINASE CASCADE IS IMPORTANT FOR ANGIOGENESIS. Transactions of the American Clinical and Climatological Association. 131: 140-146. PMID 32675854 |
0.376 |
|
| 2020 |
Xie J, An SW, Jin X, Gui Y, Huang CL. Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles. Plos One. 15: e0229799. PMID 32134975 DOI: 10.1371/Journal.Pone.0229799 |
0.378 |
|
| 2019 |
Chen JC, Lin SH, Huang CL, Cheng CJ. Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII? Proceedings of the National Academy of Sciences of the United States of America. PMID 31371516 DOI: 10.1073/Pnas.1910215116 |
0.341 |
|
| 2019 |
Wright JD, An SW, Xie J, Lim C, Huang CL. Soluble klotho regulates TRPC6 calcium signaling lipid rafts, independent of the FGFR-FGF23 pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900321R. PMID 31063704 DOI: 10.1096/Fj.201900321R |
0.344 |
|
| 2019 |
Chen JC, Lo YF, Lin YW, Lin SH, Huang CL, Cheng CJ. WNK4 kinase is a physiological intracellular chloride sensor. Proceedings of the National Academy of Sciences of the United States of America. PMID 30765526 DOI: 10.1073/Pnas.1817220116 |
0.433 |
|
| 2018 |
Taylor CA, An SW, Kankanamalage SG, Stippec S, Earnest S, Trivedi AT, Yang JZ, Mirzaei H, Huang CL, Cobb MH. OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581290 DOI: 10.1073/Pnas.1802339115 |
0.322 |
|
| 2018 |
Yang YS, Xie J, Yang SS, Lin SH, Huang CL. Differential roles of WNK4 in regulation of NCC in vivo. American Journal of Physiology. Renal Physiology. PMID 29384416 DOI: 10.1152/Ajprenal.00177.2017 |
0.406 |
|
| 2017 |
Boyd-Shiwarski CR, Shiwarski DJ, Roy A, Nkashama LJ, Namboodiri HN, Xie J, McClain KL, Marciszyn A, Kleyman TR, Tan RJ, Stolz DB, Puthenveedu MA, Huang CL, Subramanya AR. Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent. Molecular Biology of the Cell. PMID 29237822 DOI: 10.1091/Mbc.E17-08-0529 |
0.301 |
|
| 2017 |
Cheng CJ, Rodan AR, Huang CL. Emerging Targets of Diuretic Therapy. Clinical Pharmacology and Therapeutics. PMID 28560800 DOI: 10.1002/Cpt.754 |
0.349 |
|
| 2017 |
Wright JD, An SW, Xie J, Yoon J, Nischan N, Kohler JJ, Oliver N, Lim C, Huang CL. Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28442546 DOI: 10.1096/Fj.201700043R |
0.308 |
|
| 2016 |
Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL. WNK1 kinase balances T cell adhesion versus migration in vivo. Nature Immunology. PMID 27400149 DOI: 10.1038/Ni.3495 |
0.336 |
|
| 2015 |
Huang CL, Cheng CJ. A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter. Pflugers Archiv : European Journal of Physiology. PMID 25904388 DOI: 10.1007/s00424-015-1708-2 |
0.438 |
|
| 2015 |
Cheng CJ, Yoon J, Baum M, Huang CL. STE20/SPS1-related proline/alanine-rich kinase (SPAK) is critical for sodium reabsorption in isolated, perfused thick ascending limb. American Journal of Physiology. Renal Physiology. 308: F437-43. PMID 25477470 DOI: 10.1152/Ajprenal.00493.2013 |
0.443 |
|
| 2014 |
Wolf MT, An SW, Nie M, Bal MS, Huang CL. Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms. The Journal of Biological Chemistry. 289: 35849-57. PMID 25378396 DOI: 10.1074/jbc.M114.616649 |
0.309 |
|
| 2014 |
Wu Y, Schellinger JN, Huang CL, Rodan AR. Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. The Journal of Biological Chemistry. 289: 26131-42. PMID 25086033 DOI: 10.1074/Jbc.M114.577767 |
0.361 |
|
| 2011 |
Cheng CJ, Huang CL. Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. Journal of the American Society of Nephrology : Jasn. 22: 460-71. PMID 21355052 DOI: 10.1681/ASN.2010060681 |
0.315 |
|
| 2011 |
Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. The Journal of Clinical Investigation. 121: 956-65. PMID 21317537 DOI: 10.1172/Jci43475 |
0.333 |
|
| 2011 |
Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL. Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Human Molecular Genetics. 20: 855-66. PMID 21131289 DOI: 10.1093/hmg/ddq525 |
0.387 |
|
| 2011 |
Cha SK, Huang C, Ding Y, Qi X, Huang CL, Miller RT. Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1. The Journal of Biological Chemistry. 286: 1828-35. PMID 21084311 DOI: 10.1074/Jbc.M110.160390 |
0.394 |
|
| 2010 |
Rodan AR, Huang CL. An emerging role for SPAK in NCC, NKCC, and blood pressure regulation. Journal of the American Society of Nephrology : Jasn. 21: 1812-4. PMID 20930065 DOI: 10.1681/Asn.2010090926 |
0.367 |
|
| 2010 |
Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. The Journal of Biological Chemistry. 285: 25161-7. PMID 20525693 DOI: 10.1074/Jbc.M110.103432 |
0.432 |
|
| 2010 |
Cha SK, Huang CL. WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C. The Journal of Biological Chemistry. 285: 6604-11. PMID 20061383 DOI: 10.1074/jbc.M109.056044 |
0.392 |
|
| 2009 |
Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL. Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Molecular Pharmacology. 76: 38-46. PMID 19349416 DOI: 10.1124/mol.109.055780 |
0.317 |
|
| 2009 |
Liu Z, Wang HR, Huang CL. Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. The Journal of Biological Chemistry. 284: 12198-206. PMID 19244242 DOI: 10.1074/jbc.M806551200 |
0.606 |
|
| 2008 |
Wang HR, Liu Z, Huang CL. Domains of WNK1 kinase in the regulation of ROMK1. American Journal of Physiology. Renal Physiology. 295: F438-45. PMID 18550644 DOI: 10.1152/ajprenal.90287.2008 |
0.597 |
|
| 2008 |
Cha SK, Wu T, Huang CL. Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. American Journal of Physiology. Renal Physiology. 294: F1212-21. PMID 18305097 DOI: 10.1152/ajprenal.00007.2008 |
0.335 |
|
| 2007 |
Huang CL, Cha SK, Wang HR, Xie J, Cobb MH. WNKs: protein kinases with a unique kinase domain. Experimental & Molecular Medicine. 39: 565-73. PMID 18059132 DOI: 10.1038/emm.2007.62 |
0.613 |
|
| 2007 |
Huang CL, Kuo E. Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension. Nature Clinical Practice. Nephrology. 3: 623-30. PMID 17957199 DOI: 10.1038/ncpneph0638 |
0.341 |
|
| 2007 |
He G, Wang HR, Huang SK, Huang CL. Intersectin links WNK kinases to endocytosis of ROMK1. The Journal of Clinical Investigation. 117: 1078-87. PMID 17380208 DOI: 10.1172/JCI30087 |
0.606 |
|
| 2006 |
Huang CL. Probing the effects of phosphoinositides on ion channels. Methods in Molecular Biology (Clifton, N.J.). 337: 81-7. PMID 16929940 DOI: 10.1385/1-59745-095-2:81 |
0.323 |
|
| 2006 |
Xie J, Craig L, Cobb MH, Huang CL. Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatric Nephrology (Berlin, Germany). 21: 1231-6. PMID 16683163 DOI: 10.1007/s00467-006-0106-6 |
0.334 |
|
| 2006 |
Lazrak A, Liu Z, Huang CL. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proceedings of the National Academy of Sciences of the United States of America. 103: 1615-20. PMID 16428287 DOI: 10.1073/pnas.0510609103 |
0.305 |
|
| 2005 |
Yeh BI, Kim YK, Jabbar W, Huang CL. Conformational changes of pore helix coupled to gating of TRPV5 by protons. The Embo Journal. 24: 3224-34. PMID 16121193 DOI: 10.1038/Sj.Emboj.7600795 |
0.329 |
|
| 2005 |
Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. The Journal of Biological Chemistry. 280: 34218-23. PMID 16081417 DOI: 10.1074/jbc.M505735200 |
0.383 |
|
| 2005 |
Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 102: 10315-20. PMID 16006511 DOI: 10.1073/pnas.0504422102 |
0.38 |
|
| 2004 |
Babich V, Zeng WZ, Yeh BI, Ibraghimov-Beskrovnaya O, Cai Y, Somlo S, Huang CL. The N-terminal extracellular domain is required for polycystin-1-dependent channel activity. The Journal of Biological Chemistry. 279: 25582-9. PMID 15060061 DOI: 10.1074/Jbc.M402829200 |
0.303 |
|
| 2003 |
Chu PY, Quigley R, Babich V, Huang CL. Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct. American Journal of Physiology. Renal Physiology. 285: F1179-87. PMID 12952855 DOI: 10.1152/Ajprenal.00150.2003 |
0.339 |
|
| 2003 |
Zeng WZ, Li XJ, Hilgemann DW, Huang CL. Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. The Journal of Biological Chemistry. 278: 16852-6. PMID 12615924 DOI: 10.1074/Jbc.M300619200 |
0.305 |
|
| 1998 |
Huang CL, Feng S, Hilgemann DW. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ Nature. 391: 803-806. PMID 9486652 DOI: 10.1038/35882 |
0.375 |
|
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