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Anjaneyulu Kowluru - Publications

Affiliations: 
Wayne State University, Detroit, MI, United States 
Area:
Pharmacology, Pharmaceutical Chemistry, Pharmacy
Website:
https://cphs.wayne.edu/profile/af7147

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gleason N, Williams CL, Kowluru A. Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells. Molecular and Cellular Endocrinology. 112104. PMID 38013223 DOI: 10.1016/j.mce.2023.112104  0.517
2023 Kowluru A. Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1? Biochemical Pharmacology. 218: 115889. PMID 37991197 DOI: 10.1016/j.bcp.2023.115889  0.449
2023 Hali M, Pinto N, Gleason N, Kowluru A. Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells. International Journal of Molecular Sciences. 24. PMID 37958977 DOI: 10.3390/ijms242115994  0.325
2022 Hali M, Wadzinski BE, Kowluru A. Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress. Molecular and Cellular Endocrinology. 557: 111754. PMID 35987388 DOI: 10.1016/j.mce.2022.111754  0.359
2022 Gamage S, Hali M, Chen F, Kowluru A. CARD9 Mediates Pancreatic Islet Beta-Cell Dysfunction Under the Duress of Hyperglycemic Stress. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 56: 120-137. PMID 35362297 DOI: 10.33594/000000508  0.369
2021 Kowluru A, Gleason NF. Underappreciated roles for Rho GDP dissociation inhibitors (RhoGDIs) in cell function: Lessons learned from the pancreatic islet β-cell. Biochemical Pharmacology. 197: 114886. PMID 34968495 DOI: 10.1016/j.bcp.2021.114886  0.449
2021 Kowluru A. Multiple Guanine Nucleotide Exchange Factors Mediate Glucose-Induced Rac1 Activation and Insulin Secretion: Is It Precise Regulatory Control or a Case of Two Peas from the Same Pod? Acs Pharmacology & Translational Science. 4: 1702-1704. PMID 34661084 DOI: 10.1021/acsptsci.1c00190  0.441
2021 Gamage S, Hali M, Kowluru A. CARD9 mediates glucose-stimulated insulin secretion in pancreatic beta cells. Biochemical Pharmacology. 192: 114670. PMID 34233162 DOI: 10.1016/j.bcp.2021.114670  0.532
2021 Chundru SA, Harajli A, Hali M, Gleason N, Gamage S, Kowluru A. RhoG-Rac1 Signaling Pathway Mediates Metabolic Dysfunction of the Pancreatic Beta-Cells Under Chronic Hyperglycemic Conditions. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 55: 180-192. PMID 33851799 DOI: 10.33594/000000354  0.45
2020 Thamilselvan V, Gamage S, Harajli A, Chundru SA, Kowluru A. P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 54: 1218-1230. PMID 33347743 DOI: 10.33594/000000310  0.468
2020 Kowluru A. Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns. Metabolites. 10. PMID 33255484 DOI: 10.3390/metabo10120480  0.344
2020 Kowluru A. Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction. Small Gtpases. 1-13. PMID 32867592 DOI: 10.1080/21541248.2020.1815508  0.527
2020 Kowluru A. Potential roles of PP2A-Rac1 signaling axis in pancreatic β-cell dysfunction under metabolic stress: Progress and promise. Biochemical Pharmacology. 180: 114138. PMID 32634437 DOI: 10.1016/J.Bcp.2020.114138  0.508
2020 Kowluru A. GPCRs, G Proteins, and Their Impact on β-cell Function. Comprehensive Physiology. 10: 453-490. PMID 32163203 DOI: 10.1002/Cphy.C190028  0.546
2019 Qi Y, Zhang X, Seyoum B, Msallaty Z, Mallisho A, Caruso M, Damacharla D, Ma D, Al-Janabi W, Tagett R, Alharbi M, Calme G, Mestareehi A, Draghici S, Abou-Samra A, ... Kowluru A, et al. Kinome profiling reveals abnormal activity of kinases in skeletal muscle from adults with obesity and insulin resistance. The Journal of Clinical Endocrinology and Metabolism. PMID 31652310 DOI: 10.1210/Clinem/Dgz115  0.431
2019 Thamilselvan V, Kowluru A. Paradoxical regulation of glucose-induced Rac1 activation and insulin secretion by RhoGDIβ in pancreatic β-cells. Small Gtpases. 1-8. PMID 31267831 DOI: 10.1080/21541248.2019.1635403  0.607
2019 Damacharla D, Thamilselvan V, Zhang X, Mestareehi A, Yi Z, Kowluru A. Quantitative proteomics reveals novel interaction partners of Rac1 in pancreatic β-cells: Evidence for increased interaction with Rac1 under hyperglycemic conditions. Molecular and Cellular Endocrinology. 110489. PMID 31202817 DOI: 10.1016/J.Mce.2019.110489  0.5
2018 Duraisamy AJ, Mishra M, Kowluru A, Kowluru RA. Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy. Investigative Ophthalmology & Visual Science. 59: 4831-4840. PMID 30347077 DOI: 10.1167/Iovs.18-24548  0.37
2018 Kowluru A, Kowluru RA. RACking up ceramide-induced islet β-cell dysfunction. Biochemical Pharmacology. 154: 161-169. PMID 29715450 DOI: 10.1016/J.Bcp.2018.04.026  0.494
2017 Khan S, Kowluru A. CD36 mediates lipid accumulation in pancreatic beta cells under the duress of glucolipotoxic conditions: Novel roles of lysine deacetylases. Biochemical and Biophysical Research Communications. PMID 29274335 DOI: 10.1016/J.Bbrc.2017.12.111  0.392
2017 Syeda KG, Kowluru A. Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 43: 1052-1063. PMID 28968609 DOI: 10.1159/000481702  0.349
2017 Kowluru A. Role of G-proteins in islet function in health and diabetes. Diabetes, Obesity & Metabolism. 19: 63-75. PMID 28880478 DOI: 10.1111/Dom.13011  0.575
2017 Baidwan S, Chekuri A, Hynds DL, Kowluru A. Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: reversal of such metabolic defects by metformin. Apoptosis : An International Journal On Programmed Cell Death. PMID 28828705 DOI: 10.1007/S10495-017-1409-8  0.551
2017 Kowluru A. Inappropriate movement of Rac1 contributes to glucotoxicity of the islet β-cell. Cell Cycle (Georgetown, Tex.). 0. PMID 28723259 DOI: 10.1080/15384101.2017.1345229  0.369
2017 Sidarala V, Kowluru A. Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells. Apoptosis : An International Journal On Programmed Cell Death. PMID 28220272 DOI: 10.1007/S10495-017-1354-6  0.476
2017 Kowluru A. Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction. Biochemical Pharmacology. PMID 28202288 DOI: 10.1016/J.Bcp.2017.02.007  0.592
2016 Veluthakal R, Arora DK, Goalstone ML, Kowluru RA, Kowluru A. Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 39: 2110-2120. PMID 27802439 DOI: 10.1159/000447907  0.476
2016 Sidarala V, Kowluru A. The Regulatory Roles of Mitogen-activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic β-cell. Recent Patents On Endocrine, Metabolic & Immune Drug Discovery. PMID 27779078 DOI: 10.2174/1872214810666161020154905  0.568
2016 Kowluru RA, Mishra M, Kowluru A, Kumar B. Hyperlipidemia and the development of diabetic retinopathy: Comparison between type 1 and type 2 animal models. Metabolism: Clinical and Experimental. 65: 1570-81. PMID 27621192 DOI: 10.1016/J.Metabol.2016.07.012  0.318
2016 Veluthakal R, Sidarala V, Kowluru A. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 39: 760-7. PMID 27467102 DOI: 10.1159/000445666  0.518
2016 Zhang X, Damacharla D, Ma D, Qi Y, Tagett R, Draghici S, Kowluru A, Yi Z. Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells. Molecular and Cellular Endocrinology. PMID 26780722 DOI: 10.1016/J.Mce.2016.01.008  0.546
2016 Kowluru A. A lack of 'glue' misplaces Rab27A to cause islet dysfunction in diabetes. The Journal of Pathology. 238: 375-7. PMID 26575346 DOI: 10.1002/Path.4671  0.575
2015 Khadija SG, Chen F, Hadden T, Commissaris RL, Kowluru A. Nuclear Lamins: Biology and Roles in Cell Function and Dysregulation. Recent Patents On Endocrine, Metabolic & Immune Drug Discovery. PMID 26453024 DOI: 10.2174/1872214809666151009120402  0.376
2015 Veluthakal R, Tunduguru R, Arora DK, Sidarala V, Syeda K, Vlaar CP, Thurmond DC, Kowluru A. VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells. Diabetologia. 58: 2573-81. PMID 26224100 DOI: 10.1007/S00125-015-3707-4  0.541
2015 Kowluru A, Kowluru RA. Protein prenylation in islet β-cell function in health and diabetes: Putting the pieces of the puzzle together. Biochemical Pharmacology. 98: 363-70. PMID 26215874 DOI: 10.1016/J.Bcp.2015.07.004  0.519
2015 Fang J, Liu M, Zhang X, Sakamoto T, Taatjes DJ, Jena BP, Sun F, Woods J, Bryson T, Kowluru A, Zhang K, Chen X. COPII Dependent ER Export: a Critical Component of Insulin Biogenesis and Beta Cell ER Homeostasis. Molecular Endocrinology (Baltimore, Md.). me20151012. PMID 26083833 DOI: 10.1210/Me.2015-1012  0.513
2015 Veluthakal R, Kumar B, Mohammad G, Kowluru A, Kowluru RA. Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 36: 208-20. PMID 25967961 DOI: 10.1159/000374065  0.441
2015 Sidarala V, Veluthakal R, Syeda K, Vlaar C, Newsholme P, Kowluru A. Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1). Biochemical Pharmacology. 95: 301-10. PMID 25881746 DOI: 10.1016/J.Bcp.2015.04.001  0.591
2015 Sidarala V, Veluthakal R, Syeda K, Kowluru A. EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells. Cellular Signalling. 27: 1159-67. PMID 25725286 DOI: 10.1016/J.Cellsig.2015.02.020  0.617
2014 Kowluru A. On a sugary-relationship between caspases and lamins. Cell Cycle (Georgetown, Tex.). 13: 3787-8. PMID 25470565 DOI: 10.4161/15384101.2014.989948  0.546
2014 Khadija S, Veluthakal R, Sidarala V, Kowluru A. Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells. Apoptosis : An International Journal On Programmed Cell Death. 19: 1691-701. PMID 25292013 DOI: 10.1007/S10495-014-1038-4  0.568
2014 Kowluru A. Deoxysphingolipids: β-cell, beware of these new kids on the block. Diabetes. 63: 1191-3. PMID 24651803 DOI: 10.2337/Db14-0022  0.44
2014 Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Syed I, Santos JM, Mishra M. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia. 57: 1047-56. PMID 24554007 DOI: 10.1007/S00125-014-3194-Z  0.723
2014 Kowluru A, Kowluru RA. Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes. Biochemical Pharmacology. 88: 275-83. PMID 24462914 DOI: 10.1016/J.Bcp.2014.01.017  0.44
2014 Arora DK, Machhadieh B, Matti A, Wadzinski BE, Ramanadham S, Kowluru A. High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. Endocrinology. 155: 380-91. PMID 24265448 DOI: 10.1210/En.2013-1773  0.587
2014 Kowluru A, Sidarala V, Veluthakal R, Khadija S, Vlaar C. Phagocyte-Like NADPH Oxidase [Nox2] Promotes Activation of P38MAPK in Pancreatic Beta-Cells under Glucotoxic Conditions: Evidence for a Novel Role of Rac1 Free Radical Biology and Medicine. 76: S113. DOI: 10.1016/j.freeradbiomed.2014.10.239  0.338
2013 Veluthakal R, Kaetzel D, Kowluru A. Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic β-cells via Arf6-Rac1 signaling axis. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 32: 533-41. PMID 24008651 DOI: 10.1159/000354457  0.54
2013 Syeda K, Mohammed AM, Arora DK, Kowluru A. Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: protection by nifedipine. Biochemical Pharmacology. 86: 1338-46. PMID 23994168 DOI: 10.1016/J.Bcp.2013.08.023  0.808
2013 Mohammed AM, Chen F, Kowluru A. The two faces of protein palmitoylation in islet β-cell function: potential implications in the pathophysiology of islet metabolic dysregulation and diabetes. Recent Patents On Endocrine, Metabolic & Immune Drug Discovery. 7: 203-12. PMID 23829395 DOI: 10.2174/18722148113079990008  0.822
2013 Mohammed AM, Kowluru A. Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions. Islets. 5: 129-31. PMID 23695780 DOI: 10.4161/Isl.25058  0.817
2013 Mohammed AM, Syeda K, Hadden T, Kowluru A. Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate. Biochemical Pharmacology. 85: 109-14. PMID 23092759 DOI: 10.1016/J.Bcp.2012.09.024  0.816
2013 Arora DK, Mohammed AM, Kowluru A. Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells. Apoptosis : An International Journal On Programmed Cell Death. 18: 1-8. PMID 23054080 DOI: 10.1007/S10495-012-0763-9  0.818
2012 Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Islets. 4: 354-8. PMID 23114750 DOI: 10.4161/Isl.22538  0.78
2012 Jayaram B, Kowluru A. Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 1351-62. PMID 23095975 DOI: 10.1159/000343324  0.818
2012 Syed I, Szulc ZM, Ogretmen B, Kowluru A. L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 1051-8. PMID 23052231 DOI: 10.1159/000341481  0.78
2012 Kowluru A, Matti A. Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: potential mechanisms and functional consequences. Biochemical Pharmacology. 84: 591-7. PMID 22583922 DOI: 10.1016/J.Bcp.2012.05.003  0.443
2012 Matti A, Kyathanahalli C, Kowluru A. Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets. 4: 74-7. PMID 22504835 DOI: 10.4161/Isl.19121  0.595
2012 Kowluru A. Phagocyte-like NADPH oxidase mediates islet dysfunction in models of impaired insulin secretion and diabetes: So, is it “druggable”? Journal of Diabetes & Metabolism. 3. DOI: 10.4172/2155-6156.S1.016  0.353
2011 Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 60: 2843-52. PMID 21911753 DOI: 10.2337/Db11-0809  0.774
2011 Graciano MF, Valle MM, Kowluru A, Curi R, Carpinelli AR. Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets. Islets. 3: 213-23. PMID 21750413  0.422
2011 Kowluru A, Klumpp S, Krieglstein J. Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion. Naunyn-Schmiedeberg's Archives of Pharmacology. 384: 383-90. PMID 21626002 DOI: 10.1007/S00210-011-0616-Z  0.601
2011 Kyathanahalli CN, Kowluru A. A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE₂. Biochemical Pharmacology. 81: 1237-47. PMID 21406184 DOI: 10.1016/J.Bcp.2011.03.002  0.555
2011 Jayaram B, Syed I, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A. Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells. Islets. 3: 48-57. PMID 21346419 DOI: 10.4161/Isl.3.2.15016  0.829
2011 Kowluru A. Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches. Biochemical Pharmacology. 81: 965-75. PMID 21300027 DOI: 10.1016/J.Bcp.2011.01.013  0.608
2011 Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A. Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Biochemical Pharmacology. 81: 1016-27. PMID 21276423 DOI: 10.1016/J.Bcp.2011.01.006  0.831
2011 Syed I, Kyathanahalli CN, Kowluru A. Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R756-62. PMID 21228337 DOI: 10.1152/Ajpregu.00786.2010  0.805
2011 Subasinghe W, Syed I, Kowluru A. Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R12-20. PMID 20943855 DOI: 10.1152/Ajpregu.00421.2010  0.781
2010 Du Y, Kowluru A, Kern TS. PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 299. PMID 20881100 DOI: 10.1152/Ajpregu.00676.2009  0.5
2010 Kamath V, Kyathanahalli CN, Jayaram B, Syed I, Olson LK, Ludwig K, Klumpp S, Krieglstein J, Kowluru A. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. American Journal of Physiology. Endocrinology and Metabolism. 299: E276-86. PMID 20501872 DOI: 10.1152/Ajpendo.00091.2010  0.835
2010 Syed I, Jayaram B, Subasinghe W, Kowluru A. Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells. Biochemical Pharmacology. 80: 874-83. PMID 20493824 DOI: 10.1016/J.Bcp.2010.05.006  0.806
2010 Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 59: 967-77. PMID 20071600 DOI: 10.2337/Db09-1334  0.78
2010 Goalstone M, Kamath V, Kowluru A. Glucose activates prenyltransferases in pancreatic islet beta-cells. Biochemical and Biophysical Research Communications. 391: 895-8. PMID 19951701 DOI: 10.1016/J.Bbrc.2009.11.159  0.574
2010 Kowluru A. Small G proteins in islet beta-cell function. Endocrine Reviews. 31: 52-78. PMID 19890090 DOI: 10.1210/Er.2009-0022  0.551
2009 Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A. A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells Journal of Cellular and Molecular Medicine. 13: 1877-1885. PMID 20141611 DOI: 10.1111/J.1582-4934.2009.00672.X  0.761
2009 Veluthakal R, Suresh MV, Kowluru A. Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity. Molecular and Cellular Biochemistry. 329: 121-9. PMID 19367376 DOI: 10.1007/S11010-009-0113-6  0.505
2009 Veluthakal R, Madathilparambil SV, McDonald P, Olson LK, Kowluru A. Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells. Biochemical Pharmacology. 77: 101-13. PMID 18930714 DOI: 10.1016/J.Bcp.2008.09.021  0.609
2008 Kowluru A. Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell. Journal of Cellular and Molecular Medicine. 12: 1885-908. PMID 18400053 DOI: 10.1111/J.1582-4934.2008.00330.X  0.507
2008 Kowluru A. Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a perspective. Journal of Cellular and Molecular Medicine. 12: 164-73. PMID 18053094 DOI: 10.1111/J.1582-4934.2007.00168.X  0.558
2008 Susick L, Veluthakal R, Suresh MV, Hadden T, Kowluru A. Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. Journal of Cellular and Molecular Medicine. 12: 1571-83. PMID 18053091 DOI: 10.1111/J.1582-4934.2007.00171.X  0.763
2008 Kowluru A. Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell. Biochemical Pharmacology. 75: 335-45. PMID 17662254 DOI: 10.1016/J.Bcp.2007.06.035  0.536
2007 Jangati GR, Veluthakal R, Susick L, Gruber SA, Kowluru A. Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells. Endocrine. 31: 248-53. PMID 17906371 DOI: 10.1007/S12020-007-0046-3  0.815
2007 Veluthakal R, Kaur H, Goalstone M, Kowluru A. Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells. Diabetes. 56: 204-10. PMID 17192483 DOI: 10.2337/Db06-0668  0.569
2007 McDonald P, Veluthakal R, Kaur H, Kowluru A. Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells. American Journal of Physiology. Cell Physiology. 292: C1216-20. PMID 17035298 DOI: 10.1152/Ajpcell.00467.2006  0.523
2007 Kowluru RA, Kowluru A, Kanwar M. Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes. Molecular and Cellular Biochemistry. 296: 69-76. PMID 16924412 DOI: 10.1007/s11010-006-9299-z  0.342
2006 Veluthakal R, Jangati GR, Kowluru A. IL-1beta-induced iNOS expression, NO release and loss in metabolic cell viability are resistant to inhibitors of ceramide synthase and sphingomyelinase in INS 832/13 cells. Jop : Journal of the Pancreas. 7: 593-601. PMID 17095838  0.321
2006 Kowluru A, Veluthakal R, Kaetzel DM. Regulatory roles for nm23/nucleoside diphosphate kinase-like enzymes in insulin secretion from the pancreatic islet beta cell. Journal of Bioenergetics and Biomembranes. 38: 227-32. PMID 16957985 DOI: 10.1007/S10863-006-9038-X  0.536
2006 Jangati GR, Veluthakal R, Kowluru A. siRNA-mediated depletion of endogenous protein phosphatase 2Acalpha markedly attenuates ceramide-activated protein phosphatase activity in insulin-secreting INS-832/13 cells. Biochemical and Biophysical Research Communications. 348: 649-52. PMID 16884689 DOI: 10.1016/J.Bbrc.2006.07.100  0.589
2006 Veluthakal R, Wadzinski BE, Kowluru A. Localization of a nuclear serine/threonine protein phosphatase in insulin-secreting INS-1 cells: potential regulation by IL-1beta. Apoptosis : An International Journal On Programmed Cell Death. 11: 1401-11. PMID 16830232 DOI: 10.1007/S10495-006-8371-1  0.493
2005 Kowluru A, Veluthakal R. Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose-stimulated insulin secretion. Diabetes. 54: 3523-9. PMID 16306371 DOI: 10.2337/Diabetes.54.12.3523  0.58
2005 Veluthakal R, Palanivel R, Zhao Y, McDonald P, Gruber S, Kowluru A. Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell. Apoptosis : An International Journal On Programmed Cell Death. 10: 841-50. PMID 16133874 DOI: 10.1007/S10495-005-0431-4  0.474
2005 Veluthakal R, Chvyrkova I, Tannous M, McDonald P, Amin R, Hadden T, Thurmond DC, Quon MJ, Kowluru A. Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+. Diabetes. 54: 2576-85. PMID 16123345 DOI: 10.2337/Diabetes.54.9.2576  0.427
2005 Kowluru A. Novel regulatory roles for protein phosphatase-2A in the islet beta cell. Biochemical Pharmacology. 69: 1681-91. PMID 15935144 DOI: 10.1016/J.Bcp.2005.03.018  0.533
2005 Palanivel R, Veluthakal R, McDonald P, Kowluru A. Further evidence for the regulation of acetyl-CoA carboxylase activity by a glutamate- and magnesium-activated protein phosphatase in the pancreatic beta cell: defective regulation in the diabetic GK rat islet. Endocrine. 26: 71-7. PMID 15805588 DOI: 10.1385/Endo:26:1:071  0.481
2004 Kowluru A. Differential regulation by fatty acids of protein histidine phosphorylation in rat pancreatic islets. Molecular and Cellular Biochemistry. 266: 175-82. PMID 15646040 DOI: 10.1023/B:Mcbi.0000049157.03855.74  0.366
2004 Veluthakal R, Amin R, Kowluru A. Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells. American Journal of Physiology. Cell Physiology. 287: C1152-62. PMID 15201138 DOI: 10.1152/Ajpcell.00083.2004  0.4
2004 Chen HQ, Veluthakal R, Palanivel R, Kowluru A. GTP-binding protein-independent potentiation by mastoparan of IL-1beta-induced nitric oxide release from insulin-secreting HIT-T15 cells. Apoptosis : An International Journal On Programmed Cell Death. 9: 145-8. PMID 15004511 DOI: 10.1023/B:Appt.0000018796.52262.B3  0.445
2004 Kowluru RA, Kowluru A, Chakrabarti S, Khan Z. Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats. Diabetes. 53: 775-83. PMID 14988264 DOI: 10.2337/Diabetes.53.3.775  0.421
2004 Palanivel R, Veluthakal R, Kowluru A. Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells. American Journal of Physiology. Endocrinology and Metabolism. 286: E1032-41. PMID 14970009 DOI: 10.1152/Ajpendo.00587.2003  0.56
2004 Li J, Luo R, Kowluru A, Li G. Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells. American Journal of Physiology. Endocrinology and Metabolism. 286: E818-27. PMID 14736704 DOI: 10.1152/Ajpendo.00307.2003  0.541
2003 Chen HQ, Tannous M, Veluthakal R, Amin R, Kowluru A. Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells. Biochemical Pharmacology. 66: 1681-94. PMID 14563479 DOI: 10.1016/S0006-2952(03)00549-5  0.408
2003 Kowluru A, Chen HQ, Tannous M. Novel roles for the rho subfamily of GTP-binding proteins in succinate-induced insulin secretion from betaTC3 cells: further evidence in support of the succinate mechanism of insulin release. Endocrine Research. 29: 363-76. PMID 14535637 DOI: 10.1081/Erc-120025043  0.567
2003 Amin RH, Chen HQ, Veluthakal R, Silver RB, Li J, Li G, Kowluru A. Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteins. Endocrinology. 144: 4508-18. PMID 12960065 DOI: 10.1210/En.2003-0106  0.578
2003 Kowluru A. Regulatory roles for small G proteins in the pancreatic beta-cell: lessons from models of impaired insulin secretion. American Journal of Physiology. Endocrinology and Metabolism. 285: E669-84. PMID 12959934 DOI: 10.1152/Ajpendo.00196.2003  0.55
2003 Kowluru A. Defective protein histidine phosphorylation in islets from the Goto-Kakizaki diabetic rat. American Journal of Physiology. Endocrinology and Metabolism. 285: E498-503. PMID 12799314 DOI: 10.1152/Ajpendo.00121.2003  0.51
2002 Tannous M, Veluthakal R, Amin R, Kowluru A. IL-1beta-induced nitric oxide release from insulin-secreting beta-cells: further evidence for the involvement of GTP-binding proteins. Diabetes & Metabolism. 28: 3S78-84; discussion . PMID 12688637  0.321
2002 Kowluru A, Amin R. Inhibitors of post-translational modifications of G-proteins as probes to study the pancreatic beta cell function: potential therapeutic implications. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 2: 129-39. PMID 12476787  0.469
2002 Amin R, Chen HQ, Tannous M, Gibbs R, Kowluru A. Inhibition of glucose- and calcium-induced insulin secretion from βTC3 cells by novel inhibitors of protein isoprenylation Journal of Pharmacology and Experimental Therapeutics. 303: 82-88. PMID 12235236 DOI: 10.1124/Jpet.102.036160  0.452
2002 Kowluru A. Identification and characterization of a novel protein histidine kinase in the islet beta cell: evidence for its regulation by mastoparan, an activator of G-proteins and insulin secretion. Biochemical Pharmacology. 63: 2091-100. PMID 12110368 DOI: 10.1016/S0006-2952(02)01025-0  0.517
2002 Veluthakal R, Khan I, Tannous M, Kowluru A. Functional inactivation by interleukin-1beta of glyceraldehyde-3-phosphate dehydrogenase in insulin-secreting cells. Apoptosis : An International Journal On Programmed Cell Death. 7: 241-6. PMID 11997668 DOI: 10.1023/A:1015347702855  0.456
2002 Kowluru A, Morgan NG. GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell. Biochemical Pharmacology. 63: 1027-35. PMID 11931834 DOI: 10.1016/S0006-2952(02)00849-3  0.468
2002 Kowluru A, Tannous M, Chen HQ. Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Archives of Biochemistry and Biophysics. 398: 160-9. PMID 11831846 DOI: 10.1006/Abbi.2001.2710  0.441
2001 Tannous M, Amin R, Popoff MR, Fiorentini C, Kowluru A. Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells. Biochemical Pharmacology. 62: 1459-68. PMID 11728382 DOI: 10.1016/S0006-2952(01)00818-8  0.428
2001 Kowluru A, Chen HQ, Modrick LM, Stefanelli C. Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell. Diabetes. 50: 1580-7. PMID 11423479 DOI: 10.2337/Diabetes.50.7.1580  0.54
2001 Kowluru A. Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion. Diabetologia. 44: 89-94. PMID 11206416 DOI: 10.1007/S001250051584  0.467
2000 Kowluru A. Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell. Biochemical and Biophysical Research Communications. 268: 249-54. PMID 10679189 DOI: 10.1006/Bbrc.2000.2107  0.392
1999 Metz SA, Meredith M, Vadakekalam J, Rabaglia ME, Kowluru A. A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats. Diabetes. 48: 1754-62. PMID 10480605 DOI: 10.2337/Diabetes.48.9.1754  0.518
1999 Metz SA, Kowluru A. Inosine monophosphate dehydrogenase: A molecular switch integrating pleiotropic GTP-dependent beta-cell functions. Proceedings of the Association of American Physicians. 111: 335-46. PMID 10417742  0.388
1998 Kowluru A, Kowluru RA. Subcellular localization and characterization of nucleoside diphosphate kinase in rat retina: effect of diabetes. Bioscience Reports. 18: 187-198. PMID 9877232 DOI: 10.1023/A:1020100813818  0.402
1998 Kowluru A, Metz SA. Purine nucleotide- and sugar phosphate-induced inhibition of the carboxyl methylation and catalysis of protein phosphatase-2A in insulin-secreting cells: protection by divalent cations. Bioscience Reports. 18: 171-86. PMID 9877231  0.358
1998 Li G, Segu VB, Rabaglia ME, Luo RH, Kowluru A, Metz SA. Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis. Endocrinology. 139: 3752-62. PMID 9724027 DOI: 10.1210/endo.139.9.6207  0.367
1997 Kowluru A, Li G, Rabaglia ME, Segu VB, Hofmann F, Aktories K, Metz SA. Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells. Biochemical Pharmacology. 54: 1097-108. PMID 9464452  0.475
1997 Kowluru A, Metz SA. Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells. Febs Letters. 418: 179-82. PMID 9414122  0.446
1997 Kowluru A, Li G, Metz SA. Glucose activates the carboxyl methylation of gamma subunits of trimeric GTP-binding proteins in pancreatic beta cells. Modulation in vivo by calcium, GTP, and pertussis toxin. The Journal of Clinical Investigation. 100: 1596-610. PMID 9294129 DOI: 10.1172/Jci119684  0.491
1996 Kowluru A, Seavey SE, Li G, Sorenson RL, Weinhaus AJ, Nesher R, Rabaglia ME, Vadakekalam J, Metz SA. Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. The Journal of Clinical Investigation. 98: 540-55. PMID 8755667 DOI: 10.1172/JCI118822  0.451
1996 Li G, Kowluru A, Metz SA. Characterization of prenylcysteine methyltransferase in insulin-secreting cells. The Biochemical Journal. 316: 345-51. PMID 8645228 DOI: 10.1042/bj3160345  0.448
1996 Kowluru A, Seavey SE, Rabaglia ME, Nesher R, Metz SA. Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion. Endocrinology. 137: 2315-23. PMID 8641181 DOI: 10.1210/endo.137.6.8641181  0.432
1996 Kowluru A, Seavey SE, Rhodes CJ, Metz SA. A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. The Biochemical Journal. 313: 97-107. PMID 8546716 DOI: 10.1042/bj3130097  0.304
1995 Kowluru A, Seavey SE, Rabaglia ME, Metz SA. Non-specific stimulatory effects of mastoparan on pancreatic islet nucleoside diphosphokinase activity: dissociation from insulin secretion. Biochemical Pharmacology. 49: 263-6. PMID 7840804  0.413
1994 Kowluru A, Metz SA. Regulation of guanine-nucleotide binding proteins in islet subcellular fractions by phospholipase-derived lipid mediators of insulin secretion. Biochimica Et Biophysica Acta. 1222: 360-8. PMID 8038204  0.375
1994 Kowluru A, Rabaglia ME, Muse KE, Metz SA. Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells. Biochimica Et Biophysica Acta. 1222: 348-59. PMID 8038203  0.401
1994 Kowluru A, Metz SA. Characterization of nucleoside diphosphokinase activity in human and rodent pancreatic beta cells: evidence for its role in the formation of guanosine triphosphate, a permissive factor for nutrient-induced insulin secretion. Biochemistry. 33: 12495-503. PMID 7918472  0.43
1994 Kowluru A, Metz SA. Stimulation by prostaglandin E2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets. The Biochemical Journal. 297: 399-406. PMID 7905262 DOI: 10.1042/bj2970399  0.464
1993 Metz SA, Meredith M, Rabaglia ME, Kowluru A. Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5'-triphosphate in rat islets. The Journal of Clinical Investigation. 92: 872-82. PMID 8349822 DOI: 10.1172/Jci116662  0.472
1993 Metz SA, Rabaglia ME, Stock JB, Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. The Biochemical Journal. 295: 31-40. PMID 8216234 DOI: 10.1042/Bj2950031  0.444
1986 Rana RS, Kowluru A, MacDonald MJ. Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets. Archives of Biochemistry and Biophysics. 245: 411-6. PMID 3513707 DOI: 10.1016/0003-9861(86)90232-8  0.551
1986 Rana RS, Kowluru A, MacDonald MJ. Enzymes of phospholipid metabolism in rat pancreatic islets: subcellular distribution and the effect of glucose and calcium. Journal of Cellular Biochemistry. 32: 143-50. PMID 3023405 DOI: 10.1002/Jcb.240320206  0.627
1985 Rana RS, Mertz RJ, Kowluru A, Dixon JF, Hokin LE, MacDonald MJ. Evidence for glucose-responsive and -unresponsive pools of phospholipid in pancreatic islets Journal of Biological Chemistry. 260: 7861-7867. PMID 3924909  0.604
1985 MacDonald MJ, Kowluru A, Chang CM. Evidence for phosphorylation of pancreatic islet pyruvate kinase. Metabolism: Clinical and Experimental. 34: 600-3. PMID 3892225 DOI: 10.1016/0026-0495(85)90084-8  0.565
1985 MacDonald MJ, Chang CM, Kowluru A. Activation of pancreatic islet myosin ATPase by ATP and actin. Biochemical Medicine. 33: 362-6. PMID 3160344 DOI: 10.1016/0006-2944(85)90011-0  0.591
1985 MacDonald MJ, Kowluru A. Evidence for calcium enhanced phosphorylation of pyruvate kinase by pancreatic islets. Molecular and Cellular Biochemistry. 68: 107-14. PMID 3001500 DOI: 10.1007/Bf00219374  0.511
1985 Kowluru A, Rana RS, MacDonald MJ. Phospholipid methyltransferase activity in pancreatic islets: activation by calcium. Archives of Biochemistry and Biophysics. 242: 72-81. PMID 2996436 DOI: 10.1016/0003-9861(85)90481-3  0.56
1984 Kowluru A, Rana RS, MacDonald MJ. Stimulation of phospholipid methylation by glucose in pancreatic islets. Biochemical and Biophysical Research Communications. 122: 706-11. PMID 6380500 DOI: 10.1016/S0006-291X(84)80091-1  0.593
1984 Kowluru A, MacDonald MJ. Glucose-induced, calcium-mediated protein phosphorylation in intact pancreatic islets. Archives of Biochemistry and Biophysics. 231: 320-7. PMID 6375571 DOI: 10.1016/0003-9861(84)90394-1  0.627
1984 Kowluru A, MacDonald MJ. Protein phosphorylation in pancreatic islets: evidence for separate Ca2+ and cAMP-enhanced phosphorylation of two 57,000 Mr proteins. Biochemical and Biophysical Research Communications. 118: 797-804. PMID 6322766 DOI: 10.1016/0006-291X(84)91465-7  0.535
1982 MacDonald MJ, Kowluru A. Calcium-activated factors in pancreatic islets that inhibit actin polymerization. Archives of Biochemistry and Biophysics. 219: 459-62. PMID 6762149 DOI: 10.1016/0003-9861(82)90178-3  0.583
1982 MacDonald MJ, Kowluru A. Calcium-calmodulin-dependent myosin phosphorylation by pancreatic islets. Diabetes. 31: 566-70. PMID 6295860 DOI: 10.2337/Diab.31.6.566  0.544
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