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Larry M. C. Chow - Publications

Affiliations: 
Hong Kong Polytechnic University (Hong Kong) 
Area:
Pharmaceutical Chemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Dury L, Nasr R, Lorendeau D, Baiceanu E, Wong I, Zhu X, Chan KF, Chan TH, Chow L, Falson P, Di Pietro A, Baubichon-Cortay H. Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1. Biochemical Pharmacology. PMID 27984000 DOI: 10.1016/J.Bcp.2016.10.013  0.412
2016 Ashok P, Chander S, Chow LM, Wong IL, Singh RP, Jha PN, Sankaranarayanan M. Synthesis and in-vitro anti-leishmanial activity of (4-arylpiperazin-1-yl)(1-(thiophen-2-yl)-9H-pyrido[3,4-b]indol-3-yl)methanone derivatives. Bioorganic Chemistry. PMID 27939960 DOI: 10.1016/J.Bioorg.2016.11.013  0.376
2016 Yang C, Wong IL, Peng K, Liu Z, Wang P, Jiang T, Jiang T, Chow LM, Wan SB. Extending the structure-activity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors. European Journal of Medicinal Chemistry. 125: 795-806. PMID 27750197 DOI: 10.1016/J.Ejmech.2016.09.070  0.511
2016 Baiceanu E, Nguyen KA, Gonzalez-Lobato L, Nasr R, Baubichon-Cortay H, Loghin F, Le Borgne M, Chow L, Boumendjel A, Peuchmaur M, Falson P. 2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2. European Journal of Medicinal Chemistry. 122: 408-418. PMID 27393949 DOI: 10.1016/J.Ejmech.2016.06.039  0.392
2015 Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM. A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo. Molecular Pharmaceutics. PMID 26291333 DOI: 10.1021/Mp500770E  0.476
2015 Wang Z, Wong IL, Li FX, Yang C, Liu Z, Jiang T, Jiang TF, Chow LM, Wan SB. Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors. Bioorganic & Medicinal Chemistry. PMID 26233798 DOI: 10.1016/J.Bmc.2015.07.027  0.535
2015 Wong IL, Wang BC, Yuan J, Duan LX, Liu Z, Liu T, Li XM, Hu X, Zhang XY, Jiang T, Wan SB, Chow LM. Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives. Journal of Medicinal Chemistry. 58: 4529-49. PMID 25985195 DOI: 10.1021/Acs.Jmedchem.5B00085  0.49
2014 Loh CC, Suwanarusk R, Lee YQ, Chan KW, Choy KY, Rénia L, Russell B, Lear MJ, Nosten FH, Tan KS, Chow LM. Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. Plos One. 9: e110800. PMID 25343249 DOI: 10.1371/Journal.Pone.0110800  0.424
2014 Yang C, Wong IL, Jin WB, Jiang T, Chow LM, Wan SB. Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors. Marine Drugs. 12: 5209-21. PMID 25329704 DOI: 10.3390/Md12105209  0.503
2014 Zhang N, Zhang Z, Wong IL, Wan S, Chow LM, Jiang T. 4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells. European Journal of Medicinal Chemistry. 83: 74-83. PMID 24952376 DOI: 10.1016/J.Ejmech.2014.06.016  0.521
2014 Wong IL, Chan KF, Chen YF, Lun ZR, Chan TH, Chow LM. In vitro and in vivo efficacy of novel flavonoid dimers against cutaneous leishmaniasis. Antimicrobial Agents and Chemotherapy. 58: 3379-88. PMID 24687505 DOI: 10.1128/Aac.02425-13  0.39
2013 Bin JW, Wong IL, Hu X, Yu ZX, Xing LF, Jiang T, Chow LM, Biao WS. Structure-activity relationship study of permethyl ningalin B analogues as P-glycoprotein chemosensitizers. Journal of Medicinal Chemistry. 56: 9057-70. PMID 24171478 DOI: 10.1021/Jm400930E  0.5
2012 Wong IL, Chan KF, Chan TH, Chow LM. Flavonoid dimers as novel, potent antileishmanial agents. Journal of Medicinal Chemistry. 55: 8891-902. PMID 22989363 DOI: 10.1021/Jm301172V  0.375
2012 Yuan J, Wong IL, Jiang T, Wang SW, Liu T, Wen BJ, Chow LM, Wan Sheng B. Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells. European Journal of Medicinal Chemistry. 54: 413-22. PMID 22743241 DOI: 10.1016/J.Ejmech.2012.05.026  0.459
2012 Chan KF, Wong IL, Kan JW, Yan CS, Chow LM, Chan TH. Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation. Journal of Medicinal Chemistry. 55: 1999-2014. PMID 22320402 DOI: 10.1021/Jm201121B  0.545
2010 Zhang PY, Wong IL, Yan CS, Zhang XY, Jiang T, Chow LM, Wan SB. Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells. Journal of Medicinal Chemistry. 53: 5108-20. PMID 20560605 DOI: 10.1021/Jm100035C  0.519
2009 Wong IL, Chan KF, Tsang KH, Lam CY, Zhao Y, Chan TH, Chow LM. Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. Journal of Medicinal Chemistry. 52: 5311-22. PMID 19725578 DOI: 10.1021/Jm900194W  0.438
2009 Wong IL, Chan KF, Zhao Y, Chan TH, Chow LM. Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania. The Journal of Antimicrobial Chemotherapy. 63: 1179-90. PMID 19377065 DOI: 10.1093/Jac/Dkp130  0.432
2009 Chan KF, Zhao Y, Chow TW, Yan CS, Ma DL, Burkett BA, Wong IL, Chow LM, Chan TH. Flavonoid dimers as bivalent modulators for p-glycoprotein-based multidrug resistance: structure-activity relationships. Chemmedchem. 4: 594-614. PMID 19288491 DOI: 10.1002/Cmdc.200800413  0.524
2009 Chow LM, Chan TH. Novel classes of dimer antitumour drug candidates. Current Pharmaceutical Design. 15: 659-74. PMID 19199989 DOI: 10.2174/138161209787315576  0.342
2009 Chuck CP, Wong CH, Chow LM, Fung KP, Waye MM, Tsui SK. Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris. Virus Genes. 38: 1-9. PMID 18958613 DOI: 10.1007/S11262-008-0292-3  0.301
2007 Wong IL, Chan KF, Burkett BA, Zhao Y, Chai Y, Sun H, Chan TH, Chow LM. Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania. Antimicrobial Agents and Chemotherapy. 51: 930-40. PMID 17194831 DOI: 10.1128/Aac.00998-06  0.462
2006 Chan KF, Zhao Y, Burkett BA, Wong IL, Chow LM, Chan TH. Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells. Journal of Medicinal Chemistry. 49: 6742-59. PMID 17154505 DOI: 10.1021/Jm060593+  0.514
2006 Wong IL, Chow LM. The role of Leishmania enriettii multidrug resistance protein 1 (LeMDR1) in mediating drug resistance is iron-dependent. Molecular and Biochemical Parasitology. 150: 278-87. PMID 17018238 DOI: 10.1016/J.Molbiopara.2006.08.014  0.359
2005 Wong VK, Chiu P, Chung SS, Chow LM, Zhao YZ, Yang BB, Ko BC. Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 6002-11. PMID 16115945 DOI: 10.1158/1078-0432.Ccr-05-0209  0.383
2004 Lam WH, Kazi A, Kuhn DJ, Chow LM, Chan AS, Dou QP, Chan TH. A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (-)-epigallocatechin gallate [(-)-EGCG]. Bioorganic & Medicinal Chemistry. 12: 5587-93. PMID 15465336 DOI: 10.1016/J.Bmc.2004.08.002  0.355
2004 Dodge MA, Waller RF, Chow LM, Zaman MM, Cotton LM, McConville MJ, Wirth DF. Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites. Molecular Microbiology. 51: 1563-75. PMID 15009885 DOI: 10.1111/J.1365-2958.2003.03927.X  0.384
2002 Chow LM, Tang JC, Teo IT, Chui CH, Lau FY, Leung TW, Cheng G, Wong RS, Wong IL, Tsang KM, Tan WQ, Zhao YZ, Lai KB, Lam WH, Guo DA, et al. Antiproliferative activity of the extract of Gleditsia sinensis fruit on human solid tumour cell lines. Chemotherapy. 48: 303-8. PMID 12673105 DOI: 10.1159/000069713  0.315
1998 Chow LM, Volkman SK. Plasmodium and Leishmania: the role of mdr genes in mediating drug resistance. Experimental Parasitology. 90: 135-41. PMID 9709040 DOI: 10.1006/Expr.1998.4311  0.374
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