Lakshman Gunaratnam, M.D. - Publications

Affiliations: 
Immunology University of Western Ontario, London, Ontario, Canada 

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tutunea-Fatan E, Arumugarajah S, Suri RS, Edgar CR, Hon I, Dikeakos JD, Gunaratnam L. Sensing Dying Cells in Health and Disease: The Importance of Kidney Injury Molecule-1. Journal of the American Society of Nephrology : Jasn. PMID 38353655 DOI: 10.1681/ASN.0000000000000334  0.304
2021 Lee JC, Yotis DM, Lee JY, Sarabusky MA, Shrum B, Champagne A, Ismail OZ, Tutunea-Fatan E, Leong HS, Gunaratnam L. Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma. Scientific Reports. 11: 11840. PMID 34088927 DOI: 10.1038/s41598-021-90919-8  0.315
2020 Tutunea-Fatan E, Lee JC, Denker BM, Gunaratnam L. Heterotrimeric Gα Proteins in Kidney Injury and Disease. American Journal of Physiology. Renal Physiology. PMID 31984793 DOI: 10.1152/Ajprenal.00453.2019  0.416
2019 Connelly PW, Yan AT, Nash MM, Lok CE, Gunaratnam L, Prasad GVR. Growth differentiation factor 15 is decreased by kidney transplantation. Clinical Biochemistry. PMID 31361994 DOI: 10.1016/J.Clinbiochem.2019.07.013  0.343
2019 Mann S, Sener A, Luke PP, Gunaratnam L. De novo nephrolithiasis causing acute renal transplant dysfunction. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 19: 603-605. PMID 30690910 DOI: 10.1111/Ajt.15235  0.313
2019 Lee JC, Sarabusky MA, Champagne A, Lucien F, Gunaratnam L. Abstract 4604: Kidney injury molecule-1 regulates metastasis in renal cell carcinoma Cancer Research. 79: 4604-4604. DOI: 10.1158/1538-7445.Am2019-4604  0.383
2018 Yang B, Lan S, Dieudé M, Sabo-Vatasescu JP, Karakeussian-Rimbaud A, Turgeon J, Qi S, Gunaratnam L, Patey N, Hébert MJ. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology : Jasn. PMID 29925521 DOI: 10.1681/Asn.2017050581  0.386
2018 Ismail OZ, Sriranganathan S, Zhang X, Bonventre JV, Zervos AS, Gunaratnam L. Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis. Journal of Cellular Physiology. PMID 29693725 DOI: 10.1002/Jcp.26578  0.408
2018 Lee JY, Ismail OZ, Zhang X, Haig A, Lian D, Gunaratnam L. Donor Kidney Injury Molecule-1 promotes graft recovery by regulating systemic necroinflammation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 29603641 DOI: 10.1111/Ajt.14745  0.359
2016 Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, Doi K, Maehara N, Kusunoki S, Takahata A, Noiri E, ... ... Gunaratnam L, et al. Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice. Nature Medicine. PMID 26726878 DOI: 10.1038/Nm.4012  0.371
2015 Ismail O, Zhang X, Bonventre JV, Gunaratnam L. G protein, 12 (Gα12) is a negative regulator of kidney injury molecule-1-mediated efferocytosis. American Journal of Physiology. Renal Physiology. ajprenal.00169.2015. PMID 26697979 DOI: 10.1152/Ajprenal.00169.2015  0.444
2015 Lobb I, Davison M, Carter D, Liu W, Haig A, Gunaratnam L, Sener A. Hydrogen sulfide treatment mitigates renal allograft ischemia reperfusion injury during cold storage and improves early transplant kidney function and survival following allogeneic renal transplantation. The Journal of Urology. PMID 26239336 DOI: 10.1016/J.Juro.2015.07.096  0.324
2015 Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L. Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury. The American Journal of Pathology. 185: 1207-15. PMID 25759266 DOI: 10.1016/J.Ajpath.2015.02.003  0.388
2014 Gandhi R, Yi J, Ha J, Shi H, Ismail O, Nathoo S, Bonventre JV, Zhang X, Gunaratnam L. Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis. American Journal of Physiology. Renal Physiology. 307: F205-21. PMID 24829508 DOI: 10.1152/Ajprenal.00638.2013  0.363
2014 Lin Q, Chen Y, Lv J, Zhang H, Tang J, Gunaratnam L, Li X, Yang L. Kidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation American Journal of Physiology - Renal Physiology. 306: F885-F895. PMID 24523388 DOI: 10.1152/Ajprenal.00331.2013  0.405
2013 Lee L, Gunaratnam L, Sener A. Transplant renal artery stenosis secondary to mechanical compression from polycystic kidney disease: A case report. Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. 7: E251-3. PMID 23671537 DOI: 10.5489/Cuaj.548  0.313
2009 Cheong JK, Gunaratnam L, Zang ZJ, Yang CM, Sun X, Nasr SL, Sim KG, Peh BK, Rashid SB, Bonventre JV, Salto-Tellez M, Hsu SI. TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. Journal of Translational Medicine. 7: 8. PMID 19152710 DOI: 10.1186/1479-5876-7-8  0.378
2009 Gunaratnam L, Bonventre JV. HIF in kidney disease and development Journal of the American Society of Nephrology. 20: 1877-1887. PMID 19118148 DOI: 10.1681/Asn.2008070804  0.488
2009 Pelletier S, Tanguay S, Lee S, Gunaratnam L, Arbour N, Lapointe R. TGF-alpha as a candidate tumor antigen for renal cell carcinomas Cancer Immunology, Immunotherapy. 58: 1207-1218. PMID 19052740 DOI: 10.1007/S00262-008-0630-2  0.55
2009 Zang ZJ, Gunaratnam L, Cheong JK, Lai LY, Hsiao LL, O'Leary E, Sun X, Salto-Tellez M, Bonventre JV, Hsu SIH. Identification of PP2A as a novel interactor and regulator of TRIP-Br1 Cellular Signalling. 21: 34-42. PMID 18940248 DOI: 10.1016/J.Cellsig.2008.09.018  0.346
2008 Ichimura T, Asseldonk EJPV, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells Journal of Clinical Investigation. 118: 1657-1668. PMID 18414680 DOI: 10.1172/Jci34487  0.392
2008 Cheong JK, Gunaratnam L, Hsu SIH. CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein Journal of Biological Chemistry. 283: 11661-11676. PMID 18316374 DOI: 10.1074/Jbc.M708365200  0.351
2007 Franovic A, Gunaratnam L, Smith K, Robert I, Patten D, Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer Proceedings of the National Academy of Sciences of the United States of America. 104: 13092-13097. PMID 17670948 DOI: 10.1073/Pnas.0702387104  0.516
2007 Yanamadala V, Negoro H, Gunaratnam L, Kong T, Denker BM. Gα12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IκBα Journal of Biological Chemistry. 282: 24352-24363. PMID 17565996 DOI: 10.1074/Jbc.M702804200  0.389
2006 Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Research. 66: 8083-90. PMID 16912185 DOI: 10.1158/0008-5472.Can-06-1595  0.577
2005 Mekhail K, Khacho M, Carrigan A, Hache RR, Gunaratnam L, Lee S. Regulation of ubiquitin ligase dynamics by the nucleolus. The Journal of Cell Biology. 170: 733-44. PMID 16129783 DOI: 10.1083/Jcb.200506030  0.65
2005 Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Research. 65: 5221-30. PMID 15958567 DOI: 10.1158/0008-5472.Can-05-0169  0.704
2004 Mekhail K, Khacho M, Gunaratnam L, Lee S. Oxygen sensing by H+: implications for HIF and hypoxic cell memory. Cell Cycle (Georgetown, Tex.). 3: 1027-9. PMID 15280664 DOI: 10.4161/Cc.3.8.1075  0.682
2004 Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S. HIF activation by pH-dependent nucleolar sequestration of VHL. Nature Cell Biology. 6: 642-7. PMID 15181450 DOI: 10.1038/Ncb1144  0.676
2003 Gunaratnam L, Morley M, Franovic A, de Paulsen N, Mekhail K, Parolin DA, Nakamura E, Lorimer IA, Lee S. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells. The Journal of Biological Chemistry. 278: 44966-74. PMID 12944410 DOI: 10.1074/Jbc.M305502200  0.704
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