Regis J. O'Keefe, Ph.D. - Publications

Affiliations: 
2001 University of Rochester, Rochester, NY 
Area:
Cell Biology

156 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 O'Keefe RJ, Tuan RS, Lane NE, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Fortier LA, Guldberg RE, Little DG, Marshall MF, Mao JJ, Nakamura N, Robey PG, et al. American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31545883 DOI: 10.1002/jbmr.3839  0.88
2019 Shen J, Wang C, Ying J, Xu T, McAlinden A, O'Keefe RJ. Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice. Jci Insight. 4. PMID 31534049 DOI: 10.1172/jci.insight.128568  0.48
2019 Ying J, Wang P, Ding Q, Shen J, O'Keefe RJ, Chen D, Tong P, Jin H. Peripheral Blood Stem Cell Therapy Does Not Improve Outcomes of Femoral Head Osteonecrosis with Cap-shaped Separated Cartilage Defect. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31520480 DOI: 10.1002/jor.24471  0.64
2019 Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ. Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair. Annals of Biomedical Engineering. PMID 30980293 DOI: 10.1007/s10439-019-02264-7  1
2019 Zhou Y, Chen M, O'Keefe RJ, Shen J, Li Z, Zhou J, Zhou X, Mao JJ. Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. American Journal of Translational Research. 11: 1736-1747. PMID 30972197  0.6
2018 Bernstein DN, Lawson M, Menga EN, O'Keefe RJ, Rubery PT, Mesfin A. Scholarly Success of Orthopaedic Surgeons Participating in the Clinician Scholar Career Development Program. The Journal of Bone and Joint Surgery. American Volume. 100: e115. PMID 30180065 DOI: 10.2106/JBJS.17.01605  0.32
2018 Wang C, Silverman RM, Shen J, O'Keefe RJ. Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis. Journal of Orthopaedic Translation. 12: 66-73. PMID 29662780 DOI: 10.1016/j.jot.2017.12.004  0.48
2018 Ding Q, Ren Y, Che H, Ma C, Li H, Yu S, Zhang Y, An H, O'Keefe RJ, Chen D, Block JA, Yin G, Li T. Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates. American Journal of Translational Research. 10: 718-730. PMID 29636862  0.64
2018 Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice. Bone. PMID 29408411 DOI: 10.1016/j.bone.2018.02.001  0.88
2017 Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE. Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing. Scientific Reports. 7: 8658. PMID 28819185 DOI: 10.1038/s41598-017-09407-7  1
2017 Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ. DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. Jci Insight. 2. PMID 28614801 DOI: 10.1172/jci.insight.93612  0.8
2017 Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ. PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism. Journal of Cellular Biochemistry. PMID 28444901 DOI: 10.1002/jcb.26092  0.8
2016 Shen J, Abu-Amer Y, O'Keefe RJ, McAlinden A. Inflammation and epigenetic regulation in osteoarthritis. Connective Tissue Research. PMID 27389927 DOI: 10.1080/03008207.2016.1208655  0.48
2016 Zhang Y, O'Keefe RJ, Jonason JH. BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation through PPARγ Signaling. Journal of Cellular Biochemistry. PMID 27293199 DOI: 10.1002/jcb.25626  0.8
2016 Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ. NOTCH signaling in skeletal progenitors is critical for fracture repair. The Journal of Clinical Investigation. PMID 26950423 DOI: 10.1172/JCI80672  0.48
2016 Orner CA, Geary MB, Hammert WC, O'Keefe RJ, Loiselle AE. Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing. Plastic and Reconstructive Surgery. 137: 545e-53e. PMID 26910699 DOI: 10.1097/01.prs.0000475823.01907.53  1
2015 Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ. Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9. Bone Research. 3: 15021. PMID 26558140 DOI: 10.1038/boneres.2015.21  0.8
2015 Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W. Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis. Journal of Bone Oncology. 4: 69-76. PMID 26478857 DOI: 10.1016/j.jbo.2015.07.001  0.48
2015 Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ. CCN1 Regulates Chondrocyte Maturation and Cartilage Development. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 26363286 DOI: 10.1002/jbmr.2712  0.8
2015 Geary MB, Orner CA, Bawany F, Awad HA, Hammert WC, O'Keefe RJ, Loiselle AE. Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair. Plos One. 10: e0136351. PMID 26312751 DOI: 10.1371/journal.pone.0136351  1
2015 Chimenti PC, Drinkwater CJ, Li W, Lemay CA, Franklin PD, O'Keefe RJ. Factors Associated With Early Improvement in Low Back Pain After Total Hip Arthroplasty: A Multi-Center Prospective Cohort Analyses. The Journal of Arthroplasty. PMID 26276572 DOI: 10.1016/j.arth.2015.07.028  0.48
2015 Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Science Signaling. 8: ra71. PMID 26198357 DOI: 10.1126/scisignal.aaa3792  0.8
2015 Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O'Keefe RJ. Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 859-66. PMID 25761254 DOI: 10.1002/jor.22890  1
2015 Buckwalter JA, Tolo VT, O'Keefe RJ. How do you know it is true? Integrity in research and publications: AOA critical issues. The Journal of Bone and Joint Surgery. American Volume. 97: e2. PMID 25568400 DOI: 10.2106/JBJS.N.00245  0.72
2015 Wang C, Shen J, Yukata K, Inzana JA, O'Keefe RJ, Awad HA, Hilton MJ. Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. Bone. 73: 77-89. PMID 25527421 DOI: 10.1016/j.bone.2014.12.007  0.64
2015 Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ. Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. Bone. 72: 92-100. PMID 25446888 DOI: 10.1016/j.bone.2014.11.018  0.72
2015 Jonason JH, Hoak D, O'Keefe RJ. Primary murine growth plate and articular chondrocyte isolation and cell culture. Methods in Molecular Biology (Clifton, N.J.). 1226: 11-8. PMID 25331039 DOI: 10.1007/978-1-4939-1619-1_2  0.8
2015 Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O'Keefe RJ. Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 17-24. PMID 25266795 DOI: 10.1002/jor.22735  1
2014 DiGiovanni BF, Southgate RD, Mooney CJ, Chu JY, Lambert DR, O'Keefe RJ. Factors impacting musculoskeletal knowledge and clinical confidence in graduating medical students. The Journal of Bone and Joint Surgery. American Volume. 96: e185. PMID 25378518 DOI: 10.2106/JBJS.M.01283  0.72
2014 Dong Y, Long T, Wang C, Mirando AJ, Chen J, O'Keefe RJ, Hilton MJ. NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. Stem Cells Translational Medicine. 3: 1456-66. PMID 25368376 DOI: 10.5966/sctm.2014-0034  0.64
2014 Hadjiargyrou M, O'Keefe RJ. The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 2307-22. PMID 25264148 DOI: 10.1002/jbmr.2373  0.72
2014 Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X. The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair. Plos One. 9: e100079. PMID 24988184 DOI: 10.1371/journal.pone.0100079  0.72
2014 Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA. TGF-beta1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair. Journal of Cellular Physiology. PMID 24962629 DOI: 10.1002/jcp.24707  0.72
2014 Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ. Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. Plos One. 9: e99656. PMID 24911161 DOI: 10.1371/journal.pone.0099656  0.72
2014 Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. Bone. 62: 79-89. PMID 24530870 DOI: 10.1016/j.bone.2014.02.002  0.72
2014 Jonason JH, O'Keefe RJ. Isolation and culture of neonatal mouse calvarial osteoblasts. Methods in Molecular Biology (Clifton, N.J.). 1130: 295-305. PMID 24482182 DOI: 10.1007/978-1-62703-989-5_22  0.8
2014 Hasslund S, O'Keefe RJ, Awad HA. A mouse model of flexor tendon repair. Methods in Molecular Biology (Clifton, N.J.). 1130: 73-88. PMID 24482166 DOI: 10.1007/978-1-62703-989-5_6  0.64
2013 Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. Journal of Cell Science. 126: 5704-13. PMID 24144697 DOI: 10.1242/jcs.135483  0.72
2013 Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. Arthritis and Rheumatism. 65: 2623-33. PMID 23839930 DOI: 10.1002/art.38076  0.72
2013 Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis. Connective Tissue Research. 54: 218-26. PMID 23586515 DOI: 10.3109/03008207.2013.787418  0.72
2013 Ma Y, Ren Y, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT, Yin G, Li TF. Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Biochemical and Biophysical Research Communications. 431: 274-9. PMID 23291185 DOI: 10.1016/j.bbrc.2012.12.118  0.72
2013 Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 586-97. PMID 22991274 DOI: 10.1002/jbmr.1765  0.72
2012 Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing. Plos One. 7: e51411. PMID 23251524 DOI: 10.1371/journal.pone.0051411  0.72
2012 Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury. Plos One. 7: e40602. PMID 22792383 DOI: 10.1371/journal.pone.0040602  0.72
2012 Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 1680-94. PMID 22508079 DOI: 10.1002/jbmr.1639  0.8
2012 Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. Journal of Cellular Biochemistry. 113: 2156-66. PMID 22461172 DOI: 10.1002/jcb.24089  0.8
2012 Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, et al. Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis and Rheumatism. 64: 2611-23. PMID 22422036 DOI: 10.1002/art.34469  0.72
2012 Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. Development (Cambridge, England). 139: 1198-212. PMID 22354840 DOI: 10.1242/dev.070649  0.72
2012 Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 26-37. PMID 21956542 DOI: 10.1002/jbmr.518  0.72
2012 Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 30: 325-33. PMID 21809376 DOI: 10.1002/jor.21500  0.72
2012 Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM. Endogenous tissue engineering: PTH therapy for skeletal repair. Cell and Tissue Research. 347: 545-52. PMID 21626290 DOI: 10.1007/s00441-011-1188-4  0.72
2012 Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ. Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene. Journal of Cellular Physiology. 227: 1062-70. PMID 21567390 DOI: 10.1002/jcp.22819  0.72
2011 Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. Journal of Cell Science. 124: 3428-40. PMID 21984813 DOI: 10.1242/jcs.083659  0.72
2011 Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Science Translational Medicine. 3: 101ra93. PMID 21937758 DOI: 10.1126/scitranslmed.3002214  0.72
2011 Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN. The impact of Smad3 loss of function on TGF-β signaling and radiation-induced capsular contracture. Plastic and Reconstructive Surgery. 127: 2263-9. PMID 21617460 DOI: 10.1097/PRS.0b013e3182131bea  0.64
2011 Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. Establishment of an index with increased sensitivity for assessing murine arthritis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 1145-51. PMID 21374709 DOI: 10.1002/jor.21368  0.72
2011 Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN. The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 1283-94. PMID 21308771 DOI: 10.1002/jbmr.336  0.88
2011 Bukata SV, Kates SL, O'Keefe RJ. Short-term and long-term orthopaedic issues in patients with fragility fractures. Clinical Orthopaedics and Related Research. 469: 2225-36. PMID 21279487 DOI: 10.1007/s11999-011-1779-0  0.72
2011 Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM. Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1416-25. PMID 21206485 DOI: 10.1038/mt.2010.294  0.72
2011 Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN. The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 623-32. PMID 20957741 DOI: 10.1002/jor.21274  0.72
2011 Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model. Bone. 48: 562-70. PMID 20950720 DOI: 10.1016/j.bone.2010.10.003  0.72
2011 Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 792-802. PMID 20939055 DOI: 10.1002/jbmr.272  0.72
2011 Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ. Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 684-93. PMID 20842701 DOI: 10.1002/jor.21235  1
2011 Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA. Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue Engineering. Part A. 17: 389-98. PMID 20807012 DOI: 10.1089/ten.TEA.2010.0115  0.72
2010 Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'Keefe RJ, Langstein HN. A novel animal model for studying silicone gel-related capsular contracture. Plastic and Reconstructive Surgery. 126: 1483-91. PMID 21042104 DOI: 10.1097/PRS.0b013e3181ef8b8e  0.64
2010 Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA. Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. Journal of Biomedical Materials Research. Part A. 95: 717-26. PMID 20725979 DOI: 10.1002/jbm.a.32868  0.72
2010 Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ. Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. Arthritis and Rheumatism. 62: 2359-69. PMID 20506210 DOI: 10.1002/art.27537  0.72
2010 Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D. Beta-catenin, cartilage, and osteoarthritis. Annals of the New York Academy of Sciences. 1192: 344-50. PMID 20392258 DOI: 10.1111/j.1749-6632.2009.05212.x  0.8
2010 Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM. Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Annals of the New York Academy of Sciences. 1192: 84-94. PMID 20392222 DOI: 10.1111/j.1749-6632.2009.05210.x  0.72
2010 Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (Cambridge, England). 137: 1461-71. PMID 20335360 DOI: 10.1242/dev.042911  0.72
2010 Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ. TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 1784-97. PMID 20213696 DOI: 10.1002/jbmr.79  0.72
2010 Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O'Keefe RJ. Axin2 regulates chondrocyte maturation and axial skeletal development. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 89-95. PMID 19623616 DOI: 10.1002/jor.20954  0.72
2009 Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, et al. Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. Journal of Cell Science. 122: 3566-78. PMID 19737815 DOI: 10.1242/jcs.051904  0.72
2009 Frisch BJ, Porter RL, Gigliotti BJ, Olm-Shipman AJ, Weber JM, O'Keefe RJ, Jordan CT, Calvi LM. In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells. Blood. 114: 4054-63. PMID 19726721 DOI: 10.1182/blood-2009-03-205823  0.72
2009 Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4. The American Journal of Pathology. 175: 772-85. PMID 19628768 DOI: 10.2353/ajpath.2009.081099  0.72
2009 Darowish M, Rahman R, Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM, O'Keefe RJ. Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation. Bone. 45: 661-8. PMID 19524707 DOI: 10.1016/j.bone.2009.06.004  0.72
2009 Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O'Keefe RJ. Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway. American Journal of Physiology. Cell Physiology. 297: C310-20. PMID 19494233 DOI: 10.1152/ajpcell.00597.2008  0.72
2009 Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN. Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. Experimental Cell Research. 315: 2386-98. PMID 19481076 DOI: 10.1016/j.yexcr.2009.05.019  0.8
2009 Tsutsumi R, Xie C, Wei X, Zhang M, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ. PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1753-62. PMID 19419302 DOI: 10.1359/jbmr.090412  0.72
2009 Crane DP, Gromov K, Li D, Søballe K, Wahnes C, Büchner H, Hilton MJ, O'Keefe RJ, Murray CK, Schwarz EM. Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 1008-15. PMID 19173261 DOI: 10.1002/jor.20847  0.72
2009 Taylor DK, Meganck JA, Terkhorn S, Rajani R, Naik A, O'Keefe RJ, Goldstein SA, Hankenson KD. Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1043-54. PMID 19123916 DOI: 10.1359/jbmr.090101  0.72
2009 Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. muCT-based measurement of cortical bone graft-to-host union. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 899-907. PMID 19063685 DOI: 10.1359/jbmr.081232  0.72
2009 Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ. Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 833-40. PMID 19051246 DOI: 10.1002/jor.20769  0.72
2009 Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ. Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 785-92. PMID 19023895 DOI: 10.1002/jor.20805  0.88
2009 Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 251-64. PMID 18847332 DOI: 10.1359/jbmr.081002  0.72
2009 Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 12-21. PMID 18767925 DOI: 10.1359/jbmr.080901  0.8
2008 Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis and Rheumatism. 58: 3132-44. PMID 18821706 DOI: 10.1002/art.23946  0.72
2008 Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. Bone. 43: 1075-83. PMID 18773980 DOI: 10.1016/j.bone.2008.08.109  0.72
2008 Zhu M, Chen M, Zuscik M, Wu Q, Wang YJ, Rosier RN, O'Keefe RJ, Chen D. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis and Rheumatism. 58: 2053-64. PMID 18576323 DOI: 10.1002/art.23614  0.8
2008 Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM. A perspective: engineering periosteum for structural bone graft healing. Clinical Orthopaedics and Related Research. 466: 1777-87. PMID 18509709 DOI: 10.1007/s11999-008-0312-6  0.72
2008 Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. Journal of Cellular Biochemistry. 105: 219-26. PMID 18494002 DOI: 10.1002/jcb.21816  0.72
2008 Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad HA, Nakamura T, O'Keefe RJ, Schwarz EM. Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 1340-6. PMID 18404739 DOI: 10.1002/jor.20620  0.72
2008 Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. Journal of Cell Science. 121: 1455-65. PMID 18397998 DOI: 10.1242/jcs.020362  0.76
2008 Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation. The Journal of Bone and Joint Surgery. American Volume. 90: 9-13. PMID 18292350 DOI: 10.2106/JBJS.G.01212  0.72
2008 Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. The Journal of Clinical Investigation. 118: 429-38. PMID 18246193 DOI: 10.1172/JCI34174  0.88
2008 Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA. Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 824-33. PMID 18186128 DOI: 10.1002/jor.20531  0.72
2008 Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 466-73. PMID 18180771 DOI: 10.1038/sj.mt.6300395  0.72
2008 Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. Regulation of embryonic endochondral ossification by Smurf2. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 704-12. PMID 18176945 DOI: 10.1002/jor.20563  0.8
2008 Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 23: 552-63. PMID 18052755 DOI: 10.1359/jbmr.071115  0.8
2008 Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 96-105. PMID 17676625 DOI: 10.1002/jor.20452  0.72
2007 Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Annals of the New York Academy of Sciences. 1116: 82-99. PMID 18083923 DOI: 10.1196/annals.1402.082  0.68
2007 Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations. Environmental Health Perspectives. 115: 1276-82. PMID 17805416 DOI: 10.1289/ehp.10028  0.72
2007 Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner. Molecular Endocrinology (Baltimore, Md.). 21: 2805-20. PMID 17684115 DOI: 10.1210/me.2007-0199  0.72
2007 Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. Journal of Biomechanics. 40: 3178-86. PMID 17524409 DOI: 10.1016/j.jbiomech.2007.04.004  0.72
2007 Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. Recent advances in gene delivery for structural bone allografts. Tissue Engineering. 13: 1973-85. PMID 17518728 DOI: 10.1089/ten.2006.0107  0.72
2007 Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Engineering. 13: 435-45. PMID 17518596 DOI: 10.1089/ten.2006.0182  0.72
2007 Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1260-70. PMID 17488194 DOI: 10.1359/jbmr.070502  0.72
2007 Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. The Journal of Biological Chemistry. 282: 10742-8. PMID 17215250 DOI: 10.1074/jbc.M610997200  0.72
2007 Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis (New York, N.Y. : 2000). 45: 44-50. PMID 17211877 DOI: 10.1002/dvg.20261  0.88
2006 O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. COX-2 has a critical role during incorporation of structural bone allografts. Annals of the New York Academy of Sciences. 1068: 532-42. PMID 16831949 DOI: 10.1196/annals.1346.012  0.88
2006 Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. Autoimmunity and bone. Annals of the New York Academy of Sciences. 1068: 275-83. PMID 16831928 DOI: 10.1196/annals.1346.031  0.72
2006 Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X. Alteration of femoral bone morphology and density in COX-2-/- mice. Bone. 39: 767-72. PMID 16731065 DOI: 10.1016/j.bone.2006.04.006  0.72
2006 Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. The Journal of Biological Chemistry. 281: 21296-304. PMID 16690606 DOI: 10.1074/jbc.M600514200  0.72
2006 Shen R, Wang X, Drissi H, Liu F, O'Keefe RJ, Chen D. Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. The Journal of Biological Chemistry. 281: 16347-53. PMID 16613857 DOI: 10.1074/jbc.M603439200  0.8
2006 Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects. The Journal of Bone and Joint Surgery. American Volume. 88: 753-61. PMID 16595465 DOI: 10.2106/JBJS.E.00400  0.72
2006 Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H. Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. Journal of Cellular Physiology. 208: 77-86. PMID 16575901 DOI: 10.1002/jcp.20656  0.72
2006 Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene. 372: 62-70. PMID 16574347 DOI: 10.1016/j.gene.2005.12.022  0.88
2006 Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 21: 4-16. PMID 16355269 DOI: 10.1359/JBMR.050911  0.72
2006 Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ. Periprosthetic osteolysis: an immunologist's update. Current Opinion in Rheumatology. 18: 80-7. PMID 16344623  0.72
2006 Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D. Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. The Journal of Biological Chemistry. 281: 3569-76. PMID 16299379 DOI: 10.1074/jbc.M506761200  0.64
2006 Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Experimental Cell Research. 312: 40-50. PMID 16259979 DOI: 10.1016/j.yexcr.2005.09.016  0.72
2005 Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival. Febs Letters. 579: 6814-20. PMID 16330031 DOI: 10.1016/j.febslet.2005.11.018  0.72
2005 Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 2124-37. PMID 16294266 DOI: 10.1359/JBMR.050806  0.72
2005 Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. TNF-alpha and pathologic bone resorption. The Keio Journal of Medicine. 54: 127-31. PMID 16237274  0.88
2005 Voloshin I, Gelinas J, Maloney MD, O'Keefe RJ, Bigliani LU, Blaine TA. Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease Arthroscopy - Journal of Arthroscopic and Related Surgery. 21: 1076.e1-1076.e9. PMID 16171632 DOI: 10.1016/j.arthro.2005.05.017  0.72
2005 Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. Journal of Cellular Biochemistry. 96: 1262-73. PMID 16167336 DOI: 10.1002/jcb.20607  0.72
2005 Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H. Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 1624-36. PMID 16059634 DOI: 10.1359/JBMR.050516  0.88
2005 Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. Biological effects of rAAV-caAlk2 coating on structural allograft healing. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 212-8. PMID 16043092 DOI: 10.1016/j.ymthe.2005.02.026  0.72
2005 Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta. Journal of Cellular Biochemistry. 95: 1057-68. PMID 15962307 DOI: 10.1002/jcb.20466  0.88
2005 Soloviev A, Schwarz EM, Darowish M, O'Keefe RJ. Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 23: 1258-65. PMID 15949909 DOI: 10.1016/j.orthres.2005.03.019.1100230604  0.88
2005 Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 1136-48. PMID 15940366 DOI: 10.1359/JBMR.050206  0.88
2005 Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environmental Health Perspectives. 113: 749-55. PMID 15929899 DOI: 10.1289/ehp.7596  0.72
2005 Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. Cancer Research. 65: 3209-17. PMID 15833852 DOI: 10.1158/0008-5472.CAN-04-4017  0.88
2004 Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 687-96. PMID 15183422 DOI: 10.1016/j.orthres.2003.10.023  0.72
2004 Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. 34: 809-17. PMID 15121012 DOI: 10.1016/j.bone.2003.12.026  0.88
2004 Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. Journal of Cellular Biochemistry. 92: 316-31. PMID 15108358 DOI: 10.1002/jcb.20050  0.72
2004 Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. Journal of Cellular Physiology. 198: 428-40. PMID 14755548 DOI: 10.1002/jcp.10421  0.72
2004 Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 6-12. PMID 14656653 DOI: 10.1016/S0736-0266(03)00153-0  0.72
2003 Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X. Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition. Journal of Musculoskeletal & Neuronal Interactions. 3: 308-12; discussion 3. PMID 15758306  0.88
2003 Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. Journal of Cellular Biochemistry. 90: 1287-98. PMID 14635200 DOI: 10.1002/jcb.10677  0.88
2003 Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clinical Orthopaedics and Related Research. S75-85. PMID 14600595 DOI: 10.1097/01.blo.0000093048.96273.aa  0.88
2003 Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 18: 1593-604. PMID 12968668 DOI: 10.1359/jbmr.2003.18.9.1593  0.88
2003 Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 21: 908-13. PMID 12919880 DOI: 10.1016/S0736-0266(03)00008-1  0.88
2003 Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Experimental Cell Research. 288: 198-207. PMID 12878171  0.88
2003 Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology. 144: 2514-23. PMID 12746314 DOI: 10.1210/en.2002-220969  0.88
2003 Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. A phage display technique identifies a novel regulator of cell differentiation. The Journal of Biological Chemistry. 278: 438-43. PMID 12403789 DOI: 10.1074/jbc.M208292200  0.72
2002 Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 1079-90. PMID 12382976 DOI: 10.1016/S0736-0266(02)00027-X  0.88
2002 Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 811-8. PMID 12168672 DOI: 10.1016/S0736-0266(02)00007-4  0.88
2002 Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 714-22. PMID 12168659 DOI: 10.1016/S0736-0266(01)00180-2  0.88
2002 Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis and Rheumatism. 46: 1298-308. PMID 12115237 DOI: 10.1002/art.10227  0.88
2002 Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. The Journal of Clinical Investigation. 109: 1405-15. PMID 12045254 DOI: 10.1172/JCI15681  0.88
2002 Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Experimental Cell Research. 276: 310-9. PMID 12027460 DOI: 10.1006/excr.2002.5527  0.72
2002 Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 17: 915-22. PMID 12009023 DOI: 10.1359/jbmr.2002.17.5.915  0.88
2002 Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 169-73. PMID 11918293 DOI: 10.1016/S0736-0266(01)00083-3  0.88
2002 Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors. Journal of Surgical Oncology. 79: 174-9. PMID 11870668 DOI: 10.1002/jso.10067  0.88
2002 Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. COX-1 and COX-2 expression in osteoid osteomas. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 159-62. PMID 11853083 DOI: 10.1016/S0736-0266(01)00065-1  0.88
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