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Michael B. Elowitz - Publications

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Gene Circuit Dynamics in Regulation and Differentiation
Website:
http://www.hhmi.org/research/investigators/elowitz_bio.html
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81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Parres-Gold J, Levine M, Emert B, Stuart A, Elowitz MB. Principles of Computation by Competitive Protein Dimerization Networks. Biorxiv : the Preprint Server For Biology. PMID 37961250 DOI: 10.1101/2023.10.30.564854  0.762
2023 Zhu R, Santat LA, Markson JS, Nandagopal N, Gregrowicz J, Elowitz MB. Reconstitution of morphogen shuttling circuits. Science Advances. 9: eadf9336. PMID 37436981 DOI: 10.1126/sciadv.adf9336  0.765
2022 Cabera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, ... ... Elowitz MB, et al. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Systems. 13: 950-973. PMID 36549273 DOI: 10.1016/j.cels.2022.11.005  0.738
2022 Zhu R, Del Rio-Salgado JM, Garcia-Ojalvo J, Elowitz MB. Synthetic multistability in mammalian cells. Science (New York, N.Y.). 375: eabg9765. PMID 35050677 DOI: 10.1126/science.abg9765  0.308
2021 Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, et al. Single cell biology-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34605044 DOI: 10.1111/nyas.14692  0.464
2021 Chen Z, Elowitz MB. Programmable protein circuit design. Cell. PMID 33848464 DOI: 10.1016/j.cell.2021.03.007  0.711
2021 Chow KK, Budde MW, Granados AA, Cabrera M, Yoon S, Cho S, Huang TH, Koulena N, Frieda KL, Cai L, Lois C, Elowitz MB. Imaging cell lineage with a synthetic digital recording system. Science (New York, N.Y.). 372. PMID 33833095 DOI: 10.1126/science.abb3099  0.468
2020 Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB. Publisher Correction: In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Nature Biotechnology. PMID 31988471 DOI: 10.1038/S41587-020-0432-4  0.431
2019 Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB. In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Nature Biotechnology. PMID 31740838 DOI: 10.1038/S41587-019-0299-4  0.488
2019 Li P, Elowitz MB. Communication codes in developmental signaling pathways. Development (Cambridge, England). 146. PMID 31249008 DOI: 10.1242/Dev.170977  0.715
2019 Ding F, Elowitz MB. Constitutive splicing and economies of scale in gene expression. Nature Structural & Molecular Biology. PMID 31133700 DOI: 10.1038/S41594-019-0226-X  0.353
2019 Nandagopal N, Santat LA, Elowitz MB. activation in the Notch signaling pathway. Elife. 8. PMID 30628888 DOI: 10.7554/Elife.37880  0.771
2018 Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. Elife. 7. PMID 30457103 DOI: 10.7554/Elife.37851  0.406
2018 Martinez-Corral R, Raimundez E, Lin Y, Elowitz MB, Garcia-Ojalvo J. Self-Amplifying Pulsatile Protein Dynamics without Positive Feedback. Cell Systems. PMID 30316816 DOI: 10.1016/J.Cels.2018.08.012  0.359
2018 Gao XJ, Chong LS, Kim MS, Elowitz MB. Programmable protein circuits in living cells. Science (New York, N.Y.). 361: 1252-1258. PMID 30237357 DOI: 10.1126/science.aat5062  0.301
2018 Rosenthal AZ, Qi Y, Hormoz S, Park J, Li SH, Elowitz MB. Metabolic interactions between dynamic bacterial subpopulations. Elife. 7. PMID 29809139 DOI: 10.7554/Elife.33099  0.311
2018 Li P, Markson JS, Wang S, Chen S, Vachharajani V, Elowitz MB. Morphogen gradient reconstitution reveals Hedgehog pathway design principles. Science (New York, N.Y.). PMID 29622726 DOI: 10.1126/Science.Aao0645  0.725
2018 Park J, Dies M, Lin Y, Hormoz S, Smith-Unna SE, Quinodoz S, Hernández-Jiménez MJ, Garcia-Ojalvo J, Locke JCW, Elowitz MB. Molecular Time Sharing through Dynamic Pulsing in Single Cells. Cell Systems. PMID 29454936 DOI: 10.1016/J.Cels.2018.01.011  0.688
2018 Nandagopal N, Santat LA, LeBon L, Sprinzak D, Bronner ME, Elowitz MB. Dynamic Ligand Discrimination in the Notch Signaling Pathway. Cell. PMID 29398116 DOI: 10.1016/J.Cell.2018.01.002  0.778
2018 Nandagopal N, Santat LA, Elowitz MB. Author response: Cis-activation in the Notch signaling pathway Elife. DOI: 10.7554/Elife.37880.024  0.744
2018 Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY. Author response: A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment Elife. DOI: 10.7554/Elife.37851.038  0.335
2017 Antebi YE, Nandagopal N, Elowitz MB. An operational view of intercellular signaling pathways. Current Opinion in Systems Biology. 1: 16-24. PMID 29104946 DOI: 10.1016/J.Coisb.2016.12.003  0.762
2017 Antebi YE, Linton JM, Klumpe H, Bintu B, Gong M, Su C, McCardell R, Elowitz MB. Combinatorial Signal Perception in the BMP Pathway. Cell. 170: 1184-1196.e24. PMID 28886385 DOI: 10.1016/J.Cell.2017.08.015  0.392
2017 Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. Challenges and emerging directions in single-cell analysis. Genome Biology. 18: 84. PMID 28482897 DOI: 10.1186/S13059-017-1218-Y  0.529
2017 Tycko J, Van MV, Elowitz MB, Bintu L. Advancing towards a global mammalian gene regulation model through single-cell analysis and synthetic biology Current Opinion in Biomedical Engineering. 4: 174-193. DOI: 10.1016/J.Cobme.2017.10.011  0.758
2016 Hormoz S, Singer ZS, Linton JM, Antebi YE, Shraiman BI, Elowitz MB. Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements. Cell Systems. 3: 419-433.e8. PMID 27883889 DOI: 10.1016/J.Cels.2016.10.015  0.362
2016 Frieda KL, Linton JM, Hormoz S, Choi J, Chow KK, Singer ZS, Budde MW, Elowitz MB, Cai L. Synthetic recording and in situ readout of lineage information in single cells. Nature. PMID 27869821 DOI: 10.1038/Nature20777  0.557
2016 Gao XJ, Elowitz MB. Synthetic biology: Precision timing in a cell. Nature. PMID 27732579 DOI: 10.1038/Nature19478  0.394
2016 Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siu S, Bernstein ID, Elowitz MB, Rothenberg EV. Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment. Nature Immunology. 17: 956-65. PMID 27376470 DOI: 10.1038/Ni.3514  0.401
2016 Lin Y, Elowitz MB. Central Dogma Goes Digital. Molecular Cell. 61: 791-792. PMID 26990983 DOI: 10.1016/J.Molcel.2016.03.005  0.302
2016 Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB. Dynamics of epigenetic regulation at the single-cell level. Science (New York, N.Y.). 351: 720-4. PMID 26912859 DOI: 10.1126/Science.Aab2956  0.742
2015 Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB. Combinatorial gene regulation by modulation of relative pulse timing. Nature. PMID 26466562 DOI: 10.1038/Nature15710  0.57
2015 Kim DH, Marinov GK, Pepke S, Singer ZS, He P, Williams B, Schroth GP, Elowitz MB, Wold BJ. Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming. Cell Stem Cell. 16: 88-101. PMID 25575081 DOI: 10.1016/J.Stem.2014.11.005  0.417
2014 Markson JS, Elowitz MB. Synthetic biology of multicellular systems: new platforms and applications for animal cells and organisms. Acs Synthetic Biology. 3: 875-6. PMID 25524091 DOI: 10.1021/Sb500358Y  0.342
2014 Levine JH, Elowitz MB. Polyphasic feedback enables tunable cellular timers. Current Biology : Cb. 24: R994-5. PMID 25442853 DOI: 10.1016/J.Cub.2014.08.030  0.642
2014 LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 3: e02950. PMID 25255098 DOI: 10.7554/Elife.02950  0.721
2014 Dalal CK, Cai L, Lin Y, Rahbar K, Elowitz MB. Pulsatile dynamics in the yeast proteome. Current Biology : Cb. 24: 2189-94. PMID 25220054 DOI: 10.1016/J.Cub.2014.07.076  0.537
2014 Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB. Dynamic heterogeneity and DNA methylation in embryonic stem cells. Molecular Cell. 55: 319-31. PMID 25038413 DOI: 10.1016/J.Molcel.2014.06.029  0.567
2014 Tan FE, Elowitz MB. Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. Proceedings of the National Academy of Sciences of the United States of America. 111: E1740-8. PMID 24733888 DOI: 10.1073/Pnas.1320873111  0.683
2014 LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. Correction: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states Elife. 3. DOI: 10.7554/Elife.04998  0.721
2014 Sanghez V, Kee D, Beuder S, Rux D, Osawa M, Markson J, Elowitz M, Kyba M, Iacovino M. HoxA3 Controls Notch Pathway to Repress Blood Development Blood. 124: 4338-4338. DOI: 10.1182/Blood.V124.21.4338.4338  0.349
2014 Kueh HY, Elowitz M, Rothenberg E. Macrophage and T-cell fate control: insights from tracking transcription factor dynamics in single cells Experimental Hematology. 42: S16. DOI: 10.1016/J.Exphem.2014.07.054  0.457
2013 Levine JH, Lin Y, Elowitz MB. Functional roles of pulsing in genetic circuits. Science (New York, N.Y.). 342: 1193-200. PMID 24311681 DOI: 10.1126/Science.1239999  0.654
2013 Kueh HY, Champhekar A, Champhekhar A, Nutt SL, Elowitz MB, Rothenberg EV. Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science (New York, N.Y.). 341: 670-3. PMID 23868921 DOI: 10.1126/Science.1240831  0.394
2013 Young JW, Locke JC, Elowitz MB. Rate of environmental change determines stress response specificity. Proceedings of the National Academy of Sciences of the United States of America. 110: 4140-5. PMID 23407164 DOI: 10.1073/Pnas.1213060110  0.632
2012 Levine JH, Fontes ME, Dworkin J, Elowitz MB. Pulsed feedback defers cellular differentiation. Plos Biology. 10: e1001252. PMID 22303282 DOI: 10.1371/Journal.Pbio.1001252  0.618
2012 Young JW, Locke JC, Altinok A, Rosenfeld N, Bacarian T, Swain PS, Mjolsness E, Elowitz MB. Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy. Nature Protocols. 7: 80-8. PMID 22179594 DOI: 10.1038/Nprot.2011.432  0.683
2011 Sen S, Garcia-Ojalvo J, Elowitz MB. Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay. Plos One. 6: e25102. PMID 21980382 DOI: 10.1371/Journal.Pone.0025102  0.624
2011 Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB. Stochastic pulse regulation in bacterial stress response. Science (New York, N.Y.). 334: 366-9. PMID 21979936 DOI: 10.1126/Science.1208144  0.672
2011 Nandagopal N, Elowitz MB. Synthetic biology: integrated gene circuits. Science (New York, N.Y.). 333: 1244-8. PMID 21885772 DOI: 10.1126/Science.1207084  0.763
2011 Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz MB. Mutual inactivation of Notch receptors and ligands facilitates developmental patterning. Plos Computational Biology. 7: e1002069. PMID 21695234 DOI: 10.1371/Journal.Pcbi.1002069  0.789
2011 Young JW, Elowitz MB. Mixed messages: how bacteria resolve conflicting signals. Molecular Cell. 42: 405-6. PMID 21596304 DOI: 10.1016/J.Molcel.2011.05.005  0.378
2010 Acar M, Pando BF, Arnold FH, Elowitz MB, van Oudenaarden A. A general mechanism for network-dosage compensation in gene circuits. Science (New York, N.Y.). 329: 1656-60. PMID 20929850 DOI: 10.1126/Science.1190544  0.325
2010 Eldar A, Elowitz MB. Functional roles for noise in genetic circuits. Nature. 467: 167-73. PMID 20829787 DOI: 10.1038/Nature09326  0.358
2010 Cox RS, Dunlop MJ, Elowitz MB. A synthetic three-color scaffold for monitoring genetic regulation and noise. Journal of Biological Engineering. 4: 10. PMID 20646328 DOI: 10.1186/1754-1611-4-10  0.391
2010 Sprinzak D, Lakhanpal A, Lebon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB. Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature. 465: 86-90. PMID 20418862 DOI: 10.1038/Nature08959  0.797
2010 Elowitz M. Signaling Dynamics at the Single Cell Level Biophysical Journal. 98: 754a. DOI: 10.1016/J.Bpj.2009.12.4135  0.421
2009 Ca?atay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM. Architecture-dependent noise discriminates functionally analogous differentiation circuits. Cell. 139: 512-22. PMID 19853288 DOI: 10.1016/J.Cell.2009.07.046  0.722
2009 Eldar A, Chary VK, Xenopoulos P, Fontes ME, Losón OC, Dworkin J, Piggot PJ, Elowitz MB. Partial penetrance facilitates developmental evolution in bacteria. Nature. 460: 510-4. PMID 19578359 DOI: 10.1038/Nature08150  0.389
2009 Locke JC, Elowitz MB. Using movies to analyse gene circuit dynamics in single cells. Nature Reviews. Microbiology. 7: 383-92. PMID 19369953 DOI: 10.1038/Nrmicro2056  0.705
2008 Dunlop MJ, Cox RS, Levine JH, Murray RM, Elowitz MB. Regulatory activity revealed by dynamic correlations in gene expression noise. Nature Genetics. 40: 1493-8. PMID 19029898 DOI: 10.1038/Ng.281  0.594
2008 Cai L, Dalal CK, Elowitz MB. Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature. 455: 485-90. PMID 18818649 DOI: 10.1038/Nature07292  0.521
2008 Presser A, Elowitz MB, Kellis M, Kishony R. The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication. Proceedings of the National Academy of Sciences of the United States of America. 105: 950-4. PMID 18199840 DOI: 10.1073/Pnas.0707293105  0.616
2007 Cox RS, Surette MG, Elowitz MB. Programming gene expression with combinatorial promoters. Molecular Systems Biology. 3: 145. PMID 18004278 DOI: 10.1038/Msb4100187  0.345
2007 Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB. Accurate prediction of gene feedback circuit behavior from component properties. Molecular Systems Biology. 3: 143. PMID 18004276 DOI: 10.1038/Msb4100185  0.37
2007 Süel GM, Kulkarni RP, Dworkin J, Garcia-Ojalvo J, Elowitz MB. Tunability and noise dependence in differentiation dynamics. Science (New York, N.Y.). 315: 1716-9. PMID 17379809 DOI: 10.1126/Science.1137455  0.702
2006 Süel GM, Garcia-Ojalvo J, Liberman LM, Elowitz MB. An excitable gene regulatory circuit induces transient cellular differentiation. Nature. 440: 545-50. PMID 16554821 DOI: 10.1038/Nature04588  0.738
2005 Sprinzak D, Elowitz MB. Reconstruction of genetic circuits. Nature. 438: 443-8. PMID 16306982 DOI: 10.1038/Nature04335  0.345
2005 Eldar A, Elowitz M. Systems biology: Deviations in mating Nature. 437: 631-632. PMID 16193031 DOI: 10.1038/437631A  0.334
2005 Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB. Gene regulation at the single-cell level. Science (New York, N.Y.). 307: 1962-5. PMID 15790856 DOI: 10.1126/Science.1106914  0.439
2004 Garcia-Ojalvo J, Elowitz MB, Strogatz SH. Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing. Proceedings of the National Academy of Sciences of the United States of America. 101: 10955-60. PMID 15256602 DOI: 10.1073/Pnas.0307095101  0.337
2004 Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nature Genetics. 36: 147-50. PMID 14730303 DOI: 10.1038/Ng1293  0.663
2002 Rosenfeld N, Elowitz MB, Alon U. Negative autoregulation speeds the response times of transcription networks. Journal of Molecular Biology. 323: 785-93. PMID 12417193 DOI: 10.1016/S0022-2836(02)00994-4  0.393
2002 Swain PS, Elowitz MB, Siggia ED. Intrinsic and extrinsic contributions to stochasticity in gene expression. Proceedings of the National Academy of Sciences of the United States of America. 99: 12795-800. PMID 12237400 DOI: 10.1073/Pnas.162041399  0.351
2002 Elowitz MB, Levine AJ, Siggia ED, Swain PS. Stochastic gene expression in a single cell. Science (New York, N.Y.). 297: 1183-6. PMID 12183631 DOI: 10.1126/Science.1070919  0.351
2002 Guet CC, Elowitz MB, Hsing W, Leibler S. Combinatorial synthesis of genetic networks. Science (New York, N.Y.). 296: 1466-70. PMID 12029133 DOI: 10.1126/Science.1067407  0.716
2000 Elowitz MB, Leibler S. A synthetic oscillatory network of transcriptional regulators. Nature. 403: 335-8. PMID 10659856 DOI: 10.1038/35002125  0.62
1999 Elowitz MB, Surette MG, Wolf PE, Stock JB, Leibler S. Protein mobility in the cytoplasm of Escherichia coli. Journal of Bacteriology. 181: 197-203. PMID 9864330 DOI: 10.1128/Jb.181.1.197-203.1999  0.568
1998 Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proceedings of the National Academy of Sciences of the United States of America. 95: 4293-8. PMID 9539730 DOI: 10.1073/Pnas.95.8.4293  0.695
1997 Elowitz MB, Surette MG, Wolf PE, Stock J, Leibler S. Photoactivation turns green fluorescent protein red. Current Biology : Cb. 7: 809-12. PMID 9368766 DOI: 10.1016/S0960-9822(06)00342-3  0.595
1995 Bourdieu L, Duke T, Elowitz MB, Winkelmann DA, Leibler S, Libchaber A. Spiral defects in motility assays: A measure of motor protein force. Physical Review Letters. 75: 176-179. PMID 10059144 DOI: 10.1103/Physrevlett.75.176  0.549
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