| Year |
Citation |
Score |
| 2023 |
Dong L, Malkowski MG. Defining the Conformational Ensembles Associated with Ligand Binding to Cyclooxygenase-2. Biochemistry. 62: 3134-3144. PMID 37852627 DOI: 10.1021/acs.biochem.3c00341 |
0.425 |
|
| 2019 |
Dong L, Anderson A, Malkowski MG. Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex. Biochemistry. PMID 31469551 DOI: 10.1021/Acs.Biochem.9B00659 |
0.426 |
|
| 2019 |
Smith WL, Malkowski MG. Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2. The Journal of Biological Chemistry. 294: 1697-1705. PMID 30710016 DOI: 10.1074/Jbc.Tm118.006295 |
0.537 |
|
| 2018 |
Giménez-Bastida JA, Boeglin WE, Boutaud O, Malkowski MG, Schneider C. Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801018R. PMID 30096040 DOI: 10.1096/Fj.201801018R |
0.383 |
|
| 2016 |
Dong L, Yuan C, Orlando BJ, Malkowski MG, Smith WL. Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. The Journal of Biological Chemistry. PMID 27756840 DOI: 10.1074/Jbc.M116.757310 |
0.507 |
|
| 2016 |
Orlando BJ, Malkowski MG. Crystal structure of rofecoxib bound to human cyclooxygenase-2. Acta Crystallographica. Section F, Structural Biology Communications. 72: 772-776. PMID 27710942 DOI: 10.1107/S2053230X16014230 |
0.472 |
|
| 2016 |
Orlando BJ, Malkowski MG. Substrate Selective Inhibition of Cyclooxygenase-2 by Fenamic Acid Derivatives is Dependent on Peroxide Tone. The Journal of Biological Chemistry. PMID 27226593 DOI: 10.1074/Jbc.M116.725713 |
0.526 |
|
| 2016 |
Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 55: 1226-38. PMID 26859324 DOI: 10.1021/Acs.Biochem.5B01378 |
0.757 |
|
| 2015 |
Orlando BJ, Borbat PP, Georgieva ER, Freed JH, Malkowski MG. Pulsed Dipolar Spectroscopy Reveals that Tyrosyl Radicals are generated in Both Monomers of the Cyclooxygenase-2 Dimer. Biochemistry. PMID 26636181 DOI: 10.1021/Acs.Biochem.5B00979 |
0.349 |
|
| 2015 |
Otsuka T, Kirkham C, Brauer A, Koszelak-Rosenblum M, Malkowski MG, Murphy TF. The Vaccine Candidate, Substrate Binding Protein SBP2, Plays a Key Role in Arginine Uptake, which is Required for Growth of Moraxella catarrhalis. Infection and Immunity. PMID 26597985 DOI: 10.1128/Iai.00799-15 |
0.325 |
|
| 2015 |
Zhu G, Koszelak-Rosenblum M, Connelly SM, Dumont ME, Malkowski MG. The crystal structure of an integral membrane fatty acid α-hydroxylase. The Journal of Biological Chemistry. PMID 26515067 DOI: 10.1074/Jbc.M115.680124 |
0.467 |
|
| 2015 |
Bauer WJ, Luthra A, Zhu G, Radolf JD, Malkowski MG, Caimano MJ. Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding. Journal of Structural Biology. 192: 48-58. PMID 26321039 DOI: 10.1016/J.Jsb.2015.08.013 |
0.33 |
|
| 2015 |
Orlando BJ, Lucido MJ, Malkowski MG. The structure of ibuprofen bound to cyclooxygenase-2. Journal of Structural Biology. 189: 62-6. PMID 25463020 DOI: 10.1016/J.Jsb.2014.11.005 |
0.479 |
|
| 2014 |
Jones MM, Johnson A, Koszelak-Rosenblum M, Kirkham C, Brauer AL, Malkowski MG, Murphy TF. Role of the oligopeptide permease ABC Transporter of Moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract. Infection and Immunity. 82: 4758-66. PMID 25156736 DOI: 10.1128/Iai.02185-14 |
0.358 |
|
| 2014 |
Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG. Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs. Archives of Biochemistry and Biophysics. 546: 33-40. PMID 24503478 DOI: 10.1016/J.Abb.2014.01.026 |
0.436 |
|
| 2013 |
Zhu G, Koszelak-Rosenblum M, Malkowski MG. Crystal structures of α-dioxygenase from Oryza sativa: insights into substrate binding and activation by hydrogen peroxide. Protein Science : a Publication of the Protein Society. 22: 1432-8. PMID 23934749 DOI: 10.1002/Pro.2327 |
0.469 |
|
| 2013 |
Pryor EE, Horanyi PS, Clark KM, Fedoriw N, Connelly SM, Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME. Structure of the integral membrane protein CAAX protease Ste24p. Science (New York, N.Y.). 339: 1600-4. PMID 23539602 DOI: 10.1126/Science.1232048 |
0.467 |
|
| 2013 |
Goulah CC, Zhu G, Koszelak-Rosenblum M, Malkowski MG. The crystal structure of α-Dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily. Biochemistry. 52: 1364-72. PMID 23373518 DOI: 10.1021/Bi400013K |
0.449 |
|
| 2012 |
Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG. Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. The Journal of Biological Chemistry. 287: 24619-30. PMID 22637474 DOI: 10.1074/Jbc.M112.372243 |
0.755 |
|
| 2011 |
Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD. The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices. The Journal of Biological Chemistry. 286: 41656-68. PMID 21965687 DOI: 10.1074/Jbc.M111.305284 |
0.333 |
|
| 2011 |
Vecchio AJ, Malkowski MG. The structure of NS-398 bound to cyclooxygenase-2. Journal of Structural Biology. 176: 254-8. PMID 21843643 DOI: 10.1016/J.Jsb.2011.07.019 |
0.745 |
|
| 2011 |
Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. The Journal of Biological Chemistry. 286: 20736-45. PMID 21489986 DOI: 10.1074/Jbc.M111.230367 |
0.747 |
|
| 2011 |
Dong L, Vecchio AJ, Sharma NP, Jurban BJ, Malkowski MG, Smith WL. Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. The Journal of Biological Chemistry. 286: 19035-46. PMID 21467029 DOI: 10.1074/Jbc.M111.231969 |
0.721 |
|
| 2011 |
Vecchio AJ, Malkowski MG. Coordinated productive and unproductive substrate binding in the COX-2 homodimer Acta Crystallographica Section a Foundations of Crystallography. 67: C424-C424. DOI: 10.1107/S0108767311089355 |
0.717 |
|
| 2010 |
Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. The Journal of Biological Chemistry. 285: 22152-63. PMID 20463020 DOI: 10.1074/Jbc.M110.119867 |
0.77 |
|
| 2010 |
Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. The Biochemical Journal. 429: 273-82. PMID 20450491 DOI: 10.1042/Bj20091857 |
0.371 |
|
| 2010 |
Clark KM, Fedoriw N, Robinson K, Connelly SM, Randles J, Malkowski MG, DeTitta GT, Dumont ME. Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography. Protein Expression and Purification. 71: 207-23. PMID 20045057 DOI: 10.1016/J.Pep.2009.12.012 |
0.347 |
|
| 2009 |
Koszelak-Rosenblum M, Krol A, Mozumdar N, Wunsch K, Ferin A, Cook E, Veatch CK, Nagel R, Luft JR, Detitta GT, Malkowski MG. Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins. Protein Science : a Publication of the Protein Society. 18: 1828-39. PMID 19554626 DOI: 10.1002/Pro.193 |
0.317 |
|
| 2008 |
Koszelak-Rosenblum M, Krol AC, Simmons DM, Goulah CC, Wroblewski L, Malkowski MG. His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase. The Journal of Biological Chemistry. 283: 24962-71. PMID 18596034 DOI: 10.1074/Jbc.M804358200 |
0.482 |
|
| 2006 |
Lloyd T, Krol A, Campanaro D, Malkowski M. Purification, crystallization and preliminary X-ray diffraction analysis of pathogen-inducible oxygenase (PIOX) from Oryza sativa. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 365-7. PMID 16582486 DOI: 10.1107/S1744309106007305 |
0.4 |
|
| 2002 |
Garavito RM, Malkowski MG, DeWitt DL. The structures of prostaglandin endoperoxide H synthases-1 and -2. Prostaglandins & Other Lipid Mediators. 68: 129-52. PMID 12432914 DOI: 10.1016/S0090-6980(02)00026-6 |
0.5 |
|
| 2002 |
Malkowski MG, Thuresson ED, Lakkides KM, Rieke CJ, Micielli R, Garavito R, Smith WL. Fatty acid binding to cyclooxygenases International Congress Series. 1233: 283-289. DOI: 10.1016/S0531-5131(02)00243-1 |
0.318 |
|
| 2001 |
Malkowski MG, Thuresson ED, Lakkides KM, Rieke CJ, Micielli R, Smith WL, Garavito RM. Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. The Journal of Biological Chemistry. 276: 37547-55. PMID 11477109 DOI: 10.1074/Jbc.M105982200 |
0.465 |
|
| 2001 |
Thuresson ED, Malkowski MG, Lakkides KM, Rieke CJ, Mulichak AM, Ginell SL, Garavito RM, Smith WL. Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases. The Journal of Biological Chemistry. 276: 10358-65. PMID 11121413 DOI: 10.1074/Jbc.M009378200 |
0.454 |
|
| 2001 |
Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak AM, Malkowski MG, Garavito RM, Smith WL. Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid. The Journal of Biological Chemistry. 276: 10347-57. PMID 11121412 DOI: 10.1074/Jbc.M009377200 |
0.521 |
|
| 2000 |
Malkowski MG, Ginell SL, Smith WL, Garavito RM. The productive conformation of arachidonic acid bound to prostaglandin synthase. Science (New York, N.Y.). 289: 1933-7. PMID 10988074 DOI: 10.1126/Science.289.5486.1933 |
0.407 |
|
| 2000 |
Malkowski MG, Theisen MJ, Scharmen A, Garavito RM. The formation of stable fatty acid substrate complexes in prostaglandin H(2) synthase-1. Archives of Biochemistry and Biophysics. 380: 39-45. PMID 10900130 DOI: 10.1006/Abbi.2000.1906 |
0.451 |
|
| 1997 |
Malkowski MG, Martin PD, Lord ST, Edwards BF. Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16. The Biochemical Journal. 326: 815-22. PMID 9307032 DOI: 10.1042/Bj3260815 |
0.334 |
|
| 1997 |
Malkowski MG, Martin PD, Guzik JC, Edwards BF. The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. Protein Science : a Publication of the Protein Society. 6: 1438-48. PMID 9232645 DOI: 10.1002/Pro.5560060708 |
0.434 |
|
| 1997 |
Malkowski MG, Lazar JB, Johnson PH, Edwards BF. The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence. Journal of Molecular Biology. 266: 367-80. PMID 9047370 DOI: 10.1006/Jmbi.1996.0796 |
0.404 |
|
| 1996 |
Vitali J, Martin PD, Malkowski MG, Olsen CM, Johnson PH, Edwards BF. Structure of a bovine thrombin-hirudin51-65 complex determined by a combination of molecular replacement and graphics. Incorporation of known structural information in molecular replacement. Acta Crystallographica. Section D, Biological Crystallography. 52: 453-64. PMID 15299666 DOI: 10.1107/S0907444996000364 |
0.352 |
|
| 1996 |
Martin PD, Malkowski MG, DiMaio J, Konishi Y, Ni F, Edwards BF. Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues. Biochemistry. 35: 13030-9. PMID 8855938 DOI: 10.1021/Bi960656Y |
0.392 |
|
| 1995 |
Malkowski MG, Wu JY, Lazar JB, Johnson PH, Edwards BF. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. The Journal of Biological Chemistry. 270: 7077-87. PMID 7706245 DOI: 10.1074/Jbc.270.13.7077 |
0.373 |
|
| 1992 |
Vitali J, Martin PD, Malkowski MG, Robertson WD, Lazar JB, Winant RC, Johnson PH, Edwards BF. The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution. The Journal of Biological Chemistry. 267: 17670-8. PMID 1517214 DOI: 10.2210/Pdb1Hrt/Pdb |
0.447 |
|
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