Year |
Citation |
Score |
2022 |
Dickinson MS, Miyazawa T, McCool RS, Keatinge-Clay AT. Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry. Structure (London, England : 1993). PMID 35738283 DOI: 10.1016/j.str.2022.05.021 |
0.739 |
|
2021 |
Hirsch M, Fitzgerald BJ, Keatinge-Clay AT. How -Acyltransferase Assembly-Line Ketosynthases Gatekeep for Processed Polyketide Intermediates. Acs Chemical Biology. 16: 2515-2526. PMID 34590822 DOI: 10.1021/acschembio.1c00598 |
0.359 |
|
2020 |
Miyazawa T, Hirsch M, Zhang Z, Keatinge-Clay AT. An in vitro platform for engineering and harnessing modular polyketide synthases. Nature Communications. 11: 80. PMID 31900404 DOI: 10.1038/S41467-019-13811-0 |
0.381 |
|
2019 |
Zhang Z, Cepeda AJ, Robles ML, Hirsch M, Kumru K, Zhou JA, Keatinge-Clay AT. General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases. Chemical Communications (Cambridge, England). PMID 31799975 DOI: 10.1039/C9Cc07966A |
0.356 |
|
2019 |
Meinke JL, Simon AJ, Wagner DT, Morrow BR, You S, Ellington AD, Keatinge-Clay AT. Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors. Acs Synthetic Biology. PMID 31469555 DOI: 10.1021/Acssynbio.9B00047 |
0.332 |
|
2019 |
Valencia LE, Zhang Z, Cepeda AJ, Keatinge-Clay AT. Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA. Organic & Biomolecular Chemistry. PMID 30652175 DOI: 10.1039/C8Ob02858C |
0.371 |
|
2018 |
Meinke JL, Mehaffey MR, Wagner DT, Sun N, Zhang Z, Brodbelt JS, Keatinge-Clay AT. Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line. Acs Chemical Biology. PMID 30371052 DOI: 10.1021/Acschembio.8B00733 |
0.448 |
|
2018 |
Liu C, Yuan M, Xu X, Wang L, Keatinge-Clay AT, Deng Z, Lin S, Zheng J. Substrate-bound Structures of a Ketoreductase from Amphotericin Modular Polyketide Synthase. Journal of Structural Biology. PMID 29626512 DOI: 10.1016/J.Jsb.2018.04.001 |
0.449 |
|
2018 |
Vander Wood DA, Keatinge-Clay AT. The Modules of trans-Acyltransferase Assembly Lines Redefined with a Central Acyl Carrier Protein. Proteins. PMID 29524261 DOI: 10.1002/Prot.25493 |
0.395 |
|
2018 |
Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT. Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line. Acs Chemical Biology. PMID 29481043 DOI: 10.1021/Acschembio.8B00049 |
0.456 |
|
2017 |
Wagner DT, Zeng J, Bailey CB, Gay DC, Yuan F, Manion HR, Keatinge-Clay AT. Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases. Structure (London, England : 1993). PMID 28625788 DOI: 10.1016/J.Str.2017.05.011 |
0.733 |
|
2017 |
Keatinge-Clay AT. The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines. Chemical Reviews. PMID 28394118 DOI: 10.1021/Acs.Chemrev.6B00683 |
0.33 |
|
2016 |
Zeng J, Wagner DT, Zhang Z, Moretto L, Addison JD, Keatinge-Clay AT. Portability and structure of the four-helix bundle docking domains of trans-acyltransferase modular polyketide synthases. Acs Chemical Biology. PMID 27362945 DOI: 10.1021/Acschembio.6B00345 |
0.384 |
|
2016 |
Wagner DT, Stevens DC, Mehaffey MR, Manion HR, Taylor RE, Brodbelt JS, Keatinge-Clay AT. α-Methylation follows condensation in the gephyronic acid modular polyketide synthase. Chemical Communications (Cambridge, England). PMID 27346052 DOI: 10.1039/C6Cc04418B |
0.689 |
|
2016 |
Stevens DC, Wagner DT, Manion HR, Alexander BK, Keatinge-Clay AT. Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates. The Journal of Antibiotics. PMID 27301661 DOI: 10.1038/Ja.2016.66 |
0.551 |
|
2016 |
Keatinge-Clay AT. The Structural Relationship between Iterative and Modular PKSs. Cell Chemical Biology. 23: 540-2. PMID 27203374 DOI: 10.1016/J.Chembiol.2016.05.005 |
0.31 |
|
2016 |
Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE. The Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. Biochemistry. PMID 26863427 DOI: 10.1021/Acs.Biochem.6B00024 |
0.378 |
|
2015 |
Gay DC, Wagner DT, Meinke JL, Zogzas CE, Gay GR, Keatinge-Clay AT. The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex. Journal of Structural Biology. PMID 26724270 DOI: 10.1016/J.Jsb.2015.12.011 |
0.337 |
|
2015 |
Keatinge-Clay AT. Stereocontrol within polyketide assembly lines. Natural Product Reports. PMID 26584443 DOI: 10.1039/C5Np00092K |
0.415 |
|
2015 |
Bailey CB, Pasman ME, Keatinge-Clay AT. Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases. Chemical Communications (Cambridge, England). PMID 26568113 DOI: 10.1039/C5Cc07315D |
0.744 |
|
2015 |
Fage CD, Meinke JL, Keatinge-Clay AT. Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha. Journal of Molecular Catalysis. B, Enzymatic. 121: 113-121. PMID 26494979 DOI: 10.1016/J.Molcatb.2015.08.007 |
0.46 |
|
2015 |
Mugnai ML, Shi Y, Keatinge-Clay AT, Elber R. Molecular dynamics studies of modular polyketide synthase ketoreductase stereospecificity. Biochemistry. 54: 2346-59. PMID 25835227 DOI: 10.1021/Bi501401G |
0.438 |
|
2015 |
Fage CD, Isiorho EA, Liu Y, Wagner DT, Liu HW, Keatinge-Clay AT. The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition. Nature Chemical Biology. 11: 256-8. PMID 25730549 DOI: 10.1038/Nchembio.1768 |
0.406 |
|
2015 |
Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM. Structure of Salmonella FlhE, conserved member of a flagellar type III secretion operon. Journal of Molecular Biology. 427: 1254-62. PMID 25545591 DOI: 10.1016/J.Jmb.2014.11.022 |
0.372 |
|
2014 |
Fage CD, Brown DB, Boll JM, Keatinge-Clay AT, Trent MS. Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni. Acta Crystallographica. Section D, Biological Crystallography. 70: 2730-9. PMID 25286856 DOI: 10.1107/S1399004714017623 |
0.434 |
|
2014 |
Gay DC, Spear PJ, Keatinge-Clay AT. A double-hotdog with a new trick: structure and mechanism of the trans-acyltransferase polyketide synthase enoyl-isomerase. Acs Chemical Biology. 9: 2374-81. PMID 25089587 DOI: 10.1021/Cb500459B |
0.428 |
|
2014 |
Henderson JC, Fage CD, Cannon JR, Brodbelt JS, Keatinge-Clay AT, Trent MS. Antimicrobial peptide resistance of Vibrio cholerae results from an LPS modification pathway related to nonribosomal peptide synthetases. Acs Chemical Biology. 9: 2382-92. PMID 25068415 DOI: 10.1021/Cb500438X |
0.33 |
|
2014 |
Garg A, Xie X, Keatinge-Clay A, Khosla C, Cane DE. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange. Journal of the American Chemical Society. 136: 10190-3. PMID 25004372 DOI: 10.1021/Ja5056998 |
0.394 |
|
2014 |
Isiorho EA, Jeon BS, Kim NH, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn forosaminyltransferase, SpnP. Biochemistry. 53: 4292-301. PMID 24945604 DOI: 10.1021/Bi5003629 |
0.366 |
|
2014 |
Brantley JN, Bailey CB, Cannon JR, Clark KA, Vanden Bout DA, Brodbelt JS, Keatinge-Clay AT, Bielawski CW. Mechanically modulating the photophysical properties of fluorescent protein biocomposites for ratio- and intensiometric sensors. Angewandte Chemie (International Ed. in English). 53: 5088-92. PMID 24715358 DOI: 10.1002/Anie.201306988 |
0.68 |
|
2014 |
Piasecki SK, Zheng J, Axelrod AJ, Detelich ME, Keatinge-Clay AT. Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction. Proteins. 82: 2067-77. PMID 24634061 DOI: 10.1002/Prot.24561 |
0.46 |
|
2014 |
Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure (London, England : 1993). 22: 444-51. PMID 24508341 DOI: 10.1016/J.Str.2013.12.016 |
0.477 |
|
2014 |
Hughes AJ, Tibby MR, Wagner DT, Brantley JN, Keatinge-Clay AT. Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry. Chemical Communications (Cambridge, England). 50: 5276-8. PMID 24196586 DOI: 10.1039/C3Cc47513A |
0.316 |
|
2013 |
Gay D, You YO, Keatinge-Clay A, Cane DE. Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase. Biochemistry. 52: 8916-28. PMID 24274103 DOI: 10.1021/Bi400988T |
0.433 |
|
2013 |
Zheng J, Piasecki SK, Keatinge-Clay AT. Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry. Acs Chemical Biology. 8: 1964-71. PMID 23755878 DOI: 10.1021/Cb400161G |
0.394 |
|
2013 |
Zheng J, Fage CD, Demeler B, Hoffman DW, Keatinge-Clay AT. The missing linker: a dimerization motif located within polyketide synthase modules. Acs Chemical Biology. 8: 1263-70. PMID 23489133 DOI: 10.1021/Cb400047S |
0.398 |
|
2013 |
Zheng J, Keatinge-Clay AT. The status of type i polyketide synthase ketoreductases Medchemcomm. 4: 34-40. DOI: 10.1039/C2Md20191G |
0.409 |
|
2012 |
Harper AD, Bailey CB, Edwards AD, Detelich JF, Keatinge-Clay AT. Preparative, in vitro biocatalysis of triketide lactone chiral building blocks. Chembiochem : a European Journal of Chemical Biology. 13: 2200-3. PMID 22951936 DOI: 10.1002/cbic.201200378 |
0.729 |
|
2012 |
Keatinge-Clay AT. The structures of type I polyketide synthases. Natural Product Reports. 29: 1050-73. PMID 22858605 DOI: 10.1039/C2Np20019H |
0.419 |
|
2012 |
Zheng J, Gay DC, Demeler B, White MA, Keatinge-Clay AT. Divergence of multimodular polyketide synthases revealed by a didomain structure. Nature Chemical Biology. 8: 615-21. PMID 22634636 DOI: 10.1038/Nchembio.964 |
0.434 |
|
2012 |
Isiorho EA, Liu HW, Keatinge-Clay AT. Structural studies of the spinosyn rhamnosyltransferase, SpnG. Biochemistry. 51: 1213-22. PMID 22283226 DOI: 10.1021/Bi201860Q |
0.369 |
|
2012 |
Piasecki S, Keatinge-Clay AT. Monitoring biocatalytic transformations mediated by polyketide synthase enzymes in cell lysate via fluorine NMR Synlett. 23: 1840-1842. DOI: 10.1055/S-0032-1316554 |
0.367 |
|
2012 |
Hughes AJ, Detelich JF, Keatinge-Clay AT. Employing a polyketide synthase module and thioesterase in the semipreparative biocatalysis of diverse triketide pyrones Medchemcomm. 3: 956-959. DOI: 10.1039/C2Md20013A |
0.398 |
|
2011 |
Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, Komsoukaniants A, Siegel DR, Keatinge-Clay AT. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chemistry & Biology. 18: 1331-40. PMID 22035802 DOI: 10.1016/J.Chembiol.2011.07.021 |
0.381 |
|
2011 |
Zheng J, Keatinge-Clay AT. Structural and functional analysis of C2-type ketoreductases from modular polyketide synthases. Journal of Molecular Biology. 410: 105-17. PMID 21570406 DOI: 10.1016/J.Jmb.2011.04.065 |
0.417 |
|
2011 |
Hughes AJ, Keatinge-Clay A. Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB. Chemistry & Biology. 18: 165-76. PMID 21338915 DOI: 10.1016/J.Chembiol.2010.12.014 |
0.499 |
|
2010 |
Valenzano CR, You YO, Garg A, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. Journal of the American Chemical Society. 132: 14697-9. PMID 20925342 DOI: 10.1021/Ja107344H |
0.356 |
|
2010 |
Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT. Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase. Structure (London, England : 1993). 18: 913-22. PMID 20696392 DOI: 10.1016/J.Str.2010.04.015 |
0.445 |
|
2008 |
Keatinge-Clay A. Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase Journal of Molecular Biology. 384: 941-953. PMID 18952099 DOI: 10.1016/J.Jmb.2008.09.084 |
0.446 |
|
2008 |
Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9. PMID 18693734 DOI: 10.1021/Ja804453P |
0.372 |
|
2007 |
Keatinge-Clay AT. A tylosin ketoreductase reveals how chirality is determined in polyketides. Chemistry & Biology. 14: 898-908. PMID 17719489 DOI: 10.1016/J.Chembiol.2007.07.009 |
0.381 |
|
2006 |
Keatinge-Clay AT, Stroud RM. The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure (London, England : 1993). 14: 737-48. PMID 16564177 DOI: 10.1016/J.Str.2006.01.009 |
0.576 |
|
2004 |
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. An antibiotic factory caught in action. Nature Structural & Molecular Biology. 11: 888-93. PMID 15286722 DOI: 10.1038/Nsmb808 |
0.5 |
|
2003 |
Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2 |
0.679 |
|
2002 |
Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4 |
0.55 |
|
1998 |
Jacobsen JR, Keatinge-Clay AT, Cane DE, Khosla C. Precursor-directed biosynthesis of 12-ethyl erythromycin. Bioorganic & Medicinal Chemistry. 6: 1171-7. PMID 9784859 DOI: 10.1016/S0968-0896(98)00081-9 |
0.386 |
|
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