Valerie M. Weaver - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomedical Engineering, Oncology, Cell Biology

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, ... ... Weaver VM, et al. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. The Journal of Clinical Investigation. PMID 32721948 DOI: 10.1172/JCI129249  1
2020 Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, ... ... Weaver V, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews. Cancer. PMID 31980749 DOI: 10.1038/s41568-019-0238-1  0.44
2019 Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics. Journal of Visualized Experiments : Jove. PMID 31609314 DOI: 10.3791/60334  0.4
2019 Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J. Controlled modelling of human epiblast and amnion development using stem cells. Nature. PMID 31511693 DOI: 10.1038/s41586-019-1535-2  0.4
2018 Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, ... ... Weaver VM, et al. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nature Cell Biology. PMID 30202050 DOI: 10.1038/s41556-018-0183-3  1
2018 Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M. Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells. The Journal of Cell Biology. PMID 29980625 DOI: 10.1083/jcb.201703037  1
2018 Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM. New Horizons in Advocacy Engaged Physical Sciences and Oncology Research. Trends in Cancer. 4: 260-264. PMID 29606307 DOI: 10.1016/j.trecan.2018.02.002  1
2018 Northcott JM, Dean IS, Mouw JK, Weaver VM. Feeling Stress: The Mechanics of Cancer Progression and Aggression. Frontiers in Cell and Developmental Biology. 6: 17. PMID 29541636 DOI: 10.3389/fcell.2018.00017  1
2018 Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes & Development. PMID 29483153 DOI: 10.1101/gad.301366.117  0.44
2018 Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley D, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw J, ... ... Weaver VM, et al. Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma. Molecular Cancer Research : McR. PMID 29431617 DOI: 10.1158/1541-7786.MCR-17-0413  1
2017 Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 6. PMID 29266001 DOI: 10.7554/eLife.25752  1
2017 Northey JJ, Przybyla L, Weaver VM. Tissue Force Programs Cell Fate and Tumor Aggression. Cancer Discovery. PMID 29038232 DOI: 10.1158/2159-8290.CD-16-0733  1
2017 Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Elloumi-Hannachi I, Gooch K, Sarang-Sieminski AL, García AJ, Weaver VM. α5β1-integrinpromotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Molecular Biology of the Cell. PMID 28877984 DOI: 10.1091/mbc.E17-02-0126  1
2017 Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of aggressive pancreatic ductal adenocarcinomas depends on granulocyte-colony stimulating factor secretion in carcinoma cells. Cancer Immunology Research. PMID 28775207 DOI: 10.1158/2326-6066.CIR-16-0311  1
2017 Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vazquez-Naharro A, Santamaría PG, Morales S, Dubus P, Muinelo-Romay L, López López R, Tung JC, Weaver VM, Portillo F, Cano A. Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer. Cancer Research. PMID 28720577 DOI: 10.1158/0008-5472.CAN-16-3152  1
2017 Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science (New York, N.Y.). 356. PMID 28495700 DOI: 10.1126/science.aal3118  1
2017 Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. Plos One. 12: e0175112. PMID 28384203 DOI: 10.1371/journal.pone.0175112  1
2017 Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, ... ... Weaver VM, et al. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Molecular Biology of the Cell. PMID 28381423 DOI: 10.1091/mbc.E16-09-0654  1
2017 Barnes JM, Przybyla L, Weaver VM. Tissue mechanics regulate brain development, homeostasis and disease. Journal of Cell Science. 130: 71-82. PMID 28043968 DOI: 10.1242/jcs.191742  1
2016 Kaushik S, Pickup MW, Weaver VM. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Reviews. PMID 27914000 DOI: 10.1007/s10555-016-9650-0  1
2016 Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression. Nature Cell Biology. PMID 27820599 DOI: 10.1038/ncb3429  1
2016 Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. PMID 27756881 DOI: 10.18632/oncotarget.12658  0.44
2016 Weaver VM, Gilbert PM. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease. Seminars in Cell & Developmental Biology. PMID 27641825 DOI: 10.1016/j.semcdb.2016.09.004  0.96
2016 Przybyla L, Lakins JN, Weaver VM. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. PMID 27452175 DOI: 10.1016/j.stem.2016.06.018  0.4
2016 Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27334548 DOI: 10.1039/c6ib00031b  1
2016 Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S. Site-specific modulation of charge controls the structure and stimulus-responsiveness of intrinsically disordered peptide brushes. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 27203736 DOI: 10.1021/acs.langmuir.6b01099  1
2016 Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, ... ... Weaver VM, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine. PMID 27089513 DOI: 10.1038/nm.4082  1
2016 Kai F, Laklai H, Weaver VM. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends in Cell Biology. PMID 27056543 DOI: 10.1016/j.tcb.2016.03.007  1
2016 Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. The Journal of Cell Biology. 212: 707-19. PMID 26975850 DOI: 10.1083/jcb.201507054  1
2016 Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT. Physiological Ranges of Matrix Rigidity Modulate Primary Mouse Hepatocyte Function In Part Through Hepatocyte Nuclear Factor 4 Alpha. Hepatology (Baltimore, Md.). PMID 26755329 DOI: 10.1002/hep.28450  1
2016 Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM. Monitoring developmental force distributions in reconstituted embryonic epithelia Methods. 94: 101-113. DOI: 10.1016/j.ymeth.2015.09.003  0.4
2015 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, ... ... Weaver VM, et al. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 28: 831-833. PMID 28843279 DOI: 10.1016/j.ccell.2015.11.002  1
2015 Ou G, Weaver VM. Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1293-7. PMID 26439949 DOI: 10.1002/bies.201500090  1
2015 Lin C, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Molecular Biology of the Cell. PMID 26337386 DOI: 10.1091/mbc.E15-07-0456  1
2015 Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 blockade inhibits radiation-induced malignant progression in glioma. Cancer Research. PMID 26282165 DOI: 10.1158/0008-5472.CAN-14-3331  1
2015 Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25959051 DOI: 10.1039/c5ib00040h  1
2015 Northcott JM, Northey JJ, Barnes JM, Weaver VM. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. Biochimica Et Biophysica Acta. 1855: 248-53. PMID 25818365 DOI: 10.1016/j.bbcan.2015.03.004  1
2015 Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM. Tumor mechanics and metabolic dysfunction. Free Radical Biology & Medicine. 79: 269-80. PMID 25532934 DOI: 10.1016/j.freeradbiomed.2014.11.020  1
2015 Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. Journal of Biotechnology. 193: 66-9. PMID 25435379 DOI: 10.1016/j.jbiotec.2014.11.008  1
2014 Pickup MW, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. Embo Reports. 15: 1243-53. PMID 25381661 DOI: 10.15252/embr.201439246  1
2014 Mouw JK, Ou G, Weaver VM. Extracellular matrix assembly: a multiscale deconstruction. Nature Reviews. Molecular Cell Biology. 15: 771-85. PMID 25370693 DOI: 10.1038/nrm3902  1
2014 Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Research. 74: 4597-611. PMID 25183785 DOI: 10.1158/0008-5472.CAN-13-3698  1
2014 Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH. Multicellular architecture of malignant breast epithelia influences mechanics. Plos One. 9: e101955. PMID 25111489 DOI: 10.1371/journal.pone.0101955  1
2014 Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, ... ... Weaver VM, et al. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 511: 319-25. PMID 25030168 DOI: 10.1038/nature13535  1
2014 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, ... ... Weaver VM, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 25: 719-34. PMID 24856586 DOI: 10.1016/j.ccr.2014.04.005  1
2014 Michor F, Weaver VM. Understanding tissue context influences on intratumour heterogeneity. Nature Cell Biology. 16: 301-2. PMID 24691256 DOI: 10.1038/ncb2942  1
2014 Rubashkin MG, Ou G, Weaver VM. Deconstructing signaling in three dimensions. Biochemistry. 53: 2078-90. PMID 24649923 DOI: 10.1021/bi401710d  1
2014 Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nature Medicine. 20: 360-7. PMID 24633304 DOI: 10.1038/nm.3497  1
2014 Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT. Rapid disorganization of mechanically interacting systems of mammary acini. Proceedings of the National Academy of Sciences of the United States of America. 111: 658-63. PMID 24379367 DOI: 10.1073/pnas.1311312110  1
2014 Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin. Oncogene. 33: 2441-53. PMID 23770848 DOI: 10.1038/onc.2013.220  1
2014 Weaver VM. The microenvironment matters Molecular Biology of the Cell. 25: 3254-3258. DOI: 10.1091/mbc.E14-06-1080  1
2013 Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas. Cancer Research. 73: 5336-46. PMID 23856251 DOI: 10.1158/0008-5472.CAN-13-0012  1
2013 Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. Journal of Cell Science. 126: 4108-10. PMID 23843613 DOI: 10.1242/jcs.121590  1
2013 Maller O, DuFort CC, Weaver VM. YAP forces fibroblasts to feel the tension. Nature Cell Biology. 15: 570-2. PMID 23728464 DOI: 10.1038/ncb2777  1
2013 Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. The American Journal of Pathology. 182: 363-74. PMID 23219426 DOI: 10.1016/j.ajpath.2012.10.024  1
2012 Lakins JN, Chin AR, Weaver VM. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods in Molecular Biology (Clifton, N.J.). 916: 317-50. PMID 22914951 DOI: 10.1007/978-1-61779-980-8_24  1
2012 Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nature Methods. 9: 825-7. PMID 22751201 DOI: 10.1038/nmeth.2077  1
2012 Cassereau L, DuFort CC, Weaver VM. Morphogenesis: Laying down the tracks. Nature Materials. 11: 490-2. PMID 22614514 DOI: 10.1038/nmat3345  1
2012 Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. The Journal of Cell Biology. 196: 395-406. PMID 22351925 DOI: 10.1083/jcb.201102147  1
2011 Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harbor Perspectives in Biology. 3. PMID 21917992 DOI: 10.1101/cshperspect.a005058  1
2011 Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 910-21. PMID 21842067 DOI: 10.1039/c1ib00043h  1
2011 DuFort CC, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nature Reviews. Molecular Cell Biology. 12: 308-19. PMID 21508987 DOI: 10.1038/nrm3112  1
2011 Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. Journal of Surgical Oncology. 103: 468-74. PMID 21480238 DOI: 10.1002/jso.21709  1
2011 Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Physical Biology. 8: 026013. PMID 21441648 DOI: 10.1088/1478-3975/8/2/026013  1
2011 Yu H, Mouw JK, Weaver VM. Forcing form and function: biomechanical regulation of tumor evolution. Trends in Cell Biology. 21: 47-56. PMID 20870407 DOI: 10.1016/j.tcb.2010.08.015  1
2010 Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. Journal of Cell Science. 123: 4195-200. PMID 21123617 DOI: 10.1242/jcs.023820  1
2010 Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Current Opinion in Cell Biology. 22: 697-706. PMID 20822891 DOI: 10.1016/j.ceb.2010.08.015  1
2010 Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. Journal of Cellular Physiology. 225: 115-22. PMID 20648629 DOI: 10.1002/jcp.22202  1
2010 Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. The Journal of Clinical Investigation. 120: 1535-50. PMID 20389018 DOI: 10.1172/JCI39534  1
2010 Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. Journal of Cellular Physiology. 223: 667-78. PMID 20333683 DOI: 10.1002/jcp.22072  1
2010 Paszek M, Weaver V. Enforcing order on signaling Science. 327: 1335-1336. PMID 20223974 DOI: 10.1126/science.1187865  1
2009 Paszek MJ, Boettiger D, Weaver VM, Hammer DA. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. Plos Computational Biology. 5: e1000604. PMID 20011123 DOI: 10.1371/journal.pcbi.1000604  1
2009 Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 139: 891-906. PMID 19931152 DOI: 10.1016/j.cell.2009.10.027  1
2009 Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Molecular Biology of the Cell. 20: 3224-38. PMID 19458194 DOI: 10.1091/mbc.E08-12-1186  1
2009 Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM. Multiscale modeling of form and function. Science (New York, N.Y.). 324: 208-12. PMID 19359578 DOI: 10.1126/science.1170107  1
2009 Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, ... ... Weaver VM, et al. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 901-14. PMID 19258476 DOI: 10.1158/1055-9965.EPI-08-0875  1
2009 Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nature Reviews. Cancer. 9: 108-22. PMID 19165226 DOI: 10.1038/nrc2544  1
2009 Kumar S, Weaver VM. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Reviews. 28: 113-27. PMID 19153673 DOI: 10.1007/s10555-008-9173-4  1
2009 Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clinical & Experimental Metastasis. 26: 35-49. PMID 18814043 DOI: 10.1007/s10585-008-9209-8  1
2008 Lopez JI, Mouw JK, Weaver VM. Biomechanical regulation of cell orientation and fate Oncogene. 27: 6981-6993. PMID 19029939 DOI: 10.1038/onc.2008.348  1
2008 Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, et al. A human breast cell model of preinvasive to invasive transition. Cancer Research. 68: 1378-87. PMID 18316601 DOI: 10.1158/0008-5472.CAN-07-2225  1
2008 Yee KL, Weaver VM, Hammer DA. Integrin-mediated signalling through the MAP-kinase pathway. Iet Systems Biology. 2: 8-15. PMID 18248081 DOI: 10.1049/iet-syb:20060058  1
2008 Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Journal of Cell Science. 121: 226-33. PMID 18187454 DOI: 10.1242/jcs.017012  1
2008 Hebner C, Weaver VM, Debnath J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annual Review of Pathology. 3: 313-39. PMID 18039125 DOI: 10.1146/annurev.pathmechdis.3.121806.151526  1
2007 Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Developmental Cell. 13: 462-3. PMID 17925222 DOI: 10.1016/j.devcel.2007.09.013  1
2007 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 120: 3700-12. PMID 17911169 DOI: 10.1242/jcs.03484  1
2007 Kass L, Erler JT, Dembo M, Weaver VM. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. The International Journal of Biochemistry & Cell Biology. 39: 1987-94. PMID 17719831 DOI: 10.1016/j.biocel.2007.06.025  1
2007 Johnson KR, Leight JL, Weaver VM. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods in Cell Biology. 83: 547-83. PMID 17613324 DOI: 10.1016/S0091-679X(07)83023-8  1
2006 Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. Journal of Cellular Physiology. 208: 141-8. PMID 16607610 DOI: 10.1002/jcp.20639  1
2005 Yan Y, Weaver VM, Blair IA. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. Journal of Proteome Research. 4: 2007-14. PMID 16335945 DOI: 10.1021/pr050175d  1
2005 Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. Tensional homeostasis and the malignant phenotype. Cancer Cell. 8: 241-54. PMID 16169468 DOI: 10.1016/j.ccr.2005.08.010  1
2005 Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. The Journal of Biological Chemistry. 280: 24363-70. PMID 15863513 DOI: 10.1074/jbc.M411629200  1
2005 Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Molecular Biology of the Cell. 16: 1901-12. PMID 15689487 DOI: 10.1091/mbc.E04-12-1082  1
2004 Paszek MJ, Weaver VM. The tension mounts: mechanics meets morphogenesis and malignancy. Journal of Mammary Gland Biology and Neoplasia. 9: 325-42. PMID 15838603 DOI: 10.1007/s10911-004-1404-x  1
2004 Zahir N, Weaver VM. Death in the third dimension: apoptosis regulation and tissue architecture. Current Opinion in Genetics & Development. 14: 71-80. PMID 15108808 DOI: 10.1016/j.gde.2003.12.005  1
2004 Weaver VM, Gilbert P. Watch thy neighbor: cancer is a communal affair. Journal of Cell Science. 117: 1287-90. PMID 15020668 DOI: 10.1242/jcs.01137  1
2003 Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. The Journal of Cell Biology. 163: 1397-407. PMID 14691145 DOI: 10.1083/jcb.200302023  1
2003 Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. Journal of Cell Science. 116: 3543-56. PMID 12865436 DOI: 10.1242/jcs.00663  1
2002 Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: Microenvironmental influences in the normal and malignant breast Differentiation. 70: 537-546. PMID 12492495 DOI: 10.1046/j.1432-0436.2002.700907.x  1
2002 Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, Werb Z, Bissell MJ. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell. 2: 205-216. PMID 12242153 DOI: 10.1016/S1535-6108(02)00125-3  1
2002 Weaver VM. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? Developmental Cell. 2: 6-7. PMID 11782309 DOI: 10.1016/S1534-5807(01)00117-4  1
2002 Zahir N, Yeung T, Ming W, Janmey PA, Weaver VM. Peering from the outside in: Viscoelastic properties of the extracellular matrix dictate spatial organization and apoptosis resistance in mammary epithelial cells Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 430-431.  1
2001 Chrenek MA, Wong P, Weaver VM. Integrins and cell adhesions as modulators of mammary cell survival and transformation Breast Cancer Research. 3: 224-229. PMID 11434873 DOI: 10.1186/bcr300  1
1999 Weaver VM, Bissell MJ. Functional Culture Models to Study Mechanisms Governing Apoptosis in Normal and Malignant Mammary Epithelial Cells Journal of Mammary Gland Biology and Neoplasia. 4: 193-201. PMID 10426398  1
1998 Schmeichel KL, Weaver VM, Bissell MJ. Structural Cues from the Tissue Microenvironment Are Essential Determinants of the Human Mammary Epithelial Cell Phenotype Journal of Mammary Gland Biology and Neoplasia. 3: 201-213. PMID 10819528 DOI: 10.1023/A:1018751124382  1
1998 Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proceedings of the National Academy of Sciences of the United States of America. 95: 14821-6. PMID 9843973 DOI: 10.1073/pnas.95.25.14821  1
1998 Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus Proceedings of the National Academy of Sciences of the United States of America. 95: 14711-14716. PMID 9843954 DOI: 10.1073/pnas.95.25.14711  1
1998 Petersen OW, Ronnov-Jessen L, Weaver VM, Bissell MJ. Differentiation and cancer in the mammary gland: Shedding light on an old dichotomy Advances in Cancer Research. 75: 135-161. PMID 9709809 DOI: 10.1016/S0065-230X(08)60741-1  1
1997 Lelièvre S, Weaver VM, Larabell CA, Bissell MJ. Extracellular Matrix and Nuclear Matrix Interactions May Regulate Apoptosis and Tissue-Specific Gene Expression: A Concept Whose Time has Come Advances in Molecular and Cell Biology. 24: 1-55. DOI: 10.1016/S1569-2558(08)60211-8  1
1997 Weaver VM, Roskelley CD. Extracellular matrix: The central regulator of cell and tissue homeostasis Trends in Cell Biology. 7: 40-42. DOI: 10.1016/S0962-8924(97)30078-6  1
1996 Weaver VM, Fischer AH, Peterson OW, Bissell MJ. The importance of the microenvironment in breast cancer progression: Recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay Biochemistry and Cell Biology. 74: 833-851. PMID 9164652 DOI: 10.1139/o96-089  1
1995 Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ. The development of a functionally relevant cell culture model of progressive human breast cancer Seminars in Cancer Biology. 6: 175-184. PMID 7495986 DOI: 10.1006/scbi.1995.0021  1
1994 Walker PR, Weaver VM, Lach B, LeBlanc J, Sikorska M. Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis. Experimental Cell Research. 213: 100-6. PMID 8020578 DOI: 10.1006/excr.1994.1178  1
1993 Weaver VM, Welsh J. 1,25-Dihydroxycholecalciferol supplementation prevents hypocalcemia in magnesium-deficient chicks Journal of Nutrition. 123: 764-771. PMID 8463878 DOI: 10.1093/jn/123.4.764  1
1993 Weaver VM, Lach B, Walker PR, Sikorska M. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 71: 488-500. PMID 8192901 DOI: 10.1139/o93-071  1
1992 Weaver VM, Franks DJ, Welsch J. Activation of protein kinase C modulates dihydroxycholecalciferol synthesis in rat renal tubules Cellular Signalling. 4: 293-301. PMID 1324703 DOI: 10.1016/0898-6568(92)90069-K  1
1991 Welsh J, Weaver V, Simboli-Campbell M. Regulation of renal 25(OH)D3 1 alpha-hydroxylase: signal transduction pathways Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 69: 768-770. PMID 1667975 DOI: 10.1139/o91-118  1
1991 Stone LA, Weaver VM, Bruns ME, Christakos S, Welsh J. Vitamin D receptors and compensatory tissue growth in spontaneously diabetic BB rats. Annals of Nutrition & Metabolism. 35: 196-202. PMID 1654763 DOI: 10.1159/000177645  1
1989 Weaver VM, Welsh JJ. Vitamin D metabolism in magnesium deficient chicks Nutrition Research. 9: 1363-1369. DOI: 10.1016/S0271-5317(89)80161-7  1
1988 Welsh JEJ, Weaver VM. Adaptation to low dietary calcium in magnesium-deficient rats Journal of Nutrition. 118: 729-734. PMID 3373338 DOI: 10.1093/jn/118.6.729  1
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