| Year |
Citation |
Score |
| 2023 |
Cochran AG, Flynn M. GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1. Journal of Medicinal Chemistry. PMID 37702400 DOI: 10.1021/acs.jmedchem.3c01149 |
0.311 |
|
| 2022 |
Miller GM, Flynn EM, Tom J, Song A, Cochran AG. Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation. Acs Chemical Biology. PMID 35467836 DOI: 10.1021/acschembio.2c00016 |
0.547 |
|
| 2019 |
Cochran AG, Conery AR, Sims RJ. Bromodomains: a new target class for drug development. Nature Reviews. Drug Discovery. PMID 31273347 DOI: 10.1038/S41573-019-0030-7 |
0.346 |
|
| 2018 |
Wang S, Tsui V, Crawford TD, Audia JE, Burdick DJ, Beresini MH, Côté A, Cummings R, Duplessis M, Flynn EM, Hewitt MC, Huang HR, Jayaram H, Jiang Y, Joshi S, ... ... Cochran AG, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. Journal of Medicinal Chemistry. PMID 30289257 DOI: 10.1021/acs.jmedchem.8b01225 |
0.56 |
|
| 2017 |
Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM, Bai T, Zhang J, Ciferri C, Cochran AG. Non-canonical reader modules of BAZ1A promote recovery from DNA damage. Nature Communications. 8: 862. PMID 29021563 DOI: 10.1038/S41467-017-00866-0 |
0.754 |
|
| 2017 |
Oppikofer M, Bai T, Gan Y, Haley B, Liu P, Sandoval W, Ciferri C, Cochran AG. Expansion of the ISWI chromatin remodeler family with new active complexes. Embo Reports. PMID 28801535 DOI: 10.15252/Embr.201744011 |
0.774 |
|
| 2017 |
Crawford TD, Audia JE, Bellon S, Burdick DJ, Bommi-Reddy A, Côté A, Cummings RT, Duplessis M, Flynn EM, Hewitt M, Huang HR, Jayaram H, Jiang Y, Joshi S, Kiefer JR, ... ... Cochran AG, et al. GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). Acs Medicinal Chemistry Letters. 8: 737-741. PMID 28740608 DOI: 10.1021/Acsmedchemlett.7B00132 |
0.537 |
|
| 2017 |
Crawford TD, Vartanian S, Côté A, Bellon S, Duplessis M, Flynn EM, Hewitt M, Huang HR, Kiefer JR, Murray J, Nasveschuk CG, Pardo E, Romero FA, Sandy P, Tang Y, ... ... Cochran AG, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorganic & Medicinal Chemistry Letters. PMID 28606761 DOI: 10.1016/J.Bmcl.2017.05.063 |
0.565 |
|
| 2016 |
Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, ... ... Cochran AG, et al. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry. PMID 27682507 DOI: 10.1021/Acs.Jmedchem.6B01022 |
0.354 |
|
| 2016 |
Crawford TD, Tsui V, Flynn EM, Wang S, Taylor AM, Côté A, Audia JE, Beresini MH, Burdick DJ, Cummings RT, Dakin LA, Duplessis M, Good AC, Hewitt MC, Huang HR, ... ... Cochran AG, et al. Diving into the water: Inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains. Journal of Medicinal Chemistry. PMID 27219867 DOI: 10.1021/Acs.Jmedchem.6B00264 |
0.581 |
|
| 2016 |
Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, ... Cochran AG, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nature Chemical Biology. PMID 27214401 DOI: 10.1038/Nchembio.2085 |
0.565 |
|
| 2016 |
Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, ... ... Cochran AG, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Medicinal Chemistry Letters. 7: 531-536. PMID 27190605 DOI: 10.1021/Acsmedchemlett.6B00075 |
0.758 |
|
| 2016 |
Ghosh S, Taylor A, Chin M, Huang HR, Conery AR, Mertz JA, Salmeron A, Dakle PJ, Mele D, Cote A, Jayaram H, Setser JW, Poy F, Hatzivassiliou G, DeAlmeida-Nagata D, ... ... Cochran AG, et al. Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition. The Journal of Biological Chemistry. PMID 27056325 DOI: 10.1074/Jbc.M115.708560 |
0.409 |
|
| 2015 |
Flynn EM, Huang OW, Poy F, Oppikofer M, Bellon SF, Tang Y, Cochran AG. A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications. Structure (London, England : 1993). PMID 26365797 DOI: 10.1016/J.Str.2015.08.004 |
0.739 |
|
| 2015 |
Taherbhoy AM, Huang OW, Cochran AG. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nature Communications. 6: 7621. PMID 26151332 DOI: 10.1038/Ncomms8621 |
0.746 |
|
| 2015 |
Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 518: 417-21. PMID 25470037 DOI: 10.1038/Nature13979 |
0.733 |
|
| 2013 |
Huang OW, Cochran AG. Regulation of deubiquitinase proteolytic activity. Current Opinion in Structural Biology. 23: 806-11. PMID 23962487 DOI: 10.1016/J.Sbi.2013.07.012 |
0.78 |
|
| 2012 |
Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG. Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural and Molecular Biology. 19: 171-176. PMID 22245969 DOI: 10.1038/Nsmb.2206 |
0.775 |
|
| 2011 |
Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, ... ... Cochran AG, et al. Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Structure (London, England : 1993). 19: 1433-42. PMID 21944579 DOI: 10.1016/J.Str.2011.07.005 |
0.762 |
|
| 2011 |
Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG. Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. The Embo Journal. 30: 3285-97. PMID 21772249 DOI: 10.1038/Emboj.2011.243 |
0.793 |
|
| 2011 |
Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG. Abstract A160: Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A160 |
0.802 |
|
| 2010 |
Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. The Journal of Biological Chemistry. 285: 9172-9. PMID 20093360 DOI: 10.1074/Jbc.M109.092130 |
0.657 |
|
| 2009 |
Bourhis E, Lingel A, Phung Q, Fairbrother WJ, Cochran AG. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry. 48: 6783-93. PMID 19530738 DOI: 10.1021/Bi900530V |
0.656 |
|
| 2009 |
Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, ... ... Cochran AG, et al. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Journal of Medicinal Chemistry. 52: 3300-7. PMID 19402633 DOI: 10.1021/Jm9000314 |
0.763 |
|
| 2008 |
Rawson TE, Rüth M, Blackwood E, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Georges GJ, Goller B, Halladay J, Hunsaker T, Kleinheinz T, Krell HW, Li J, ... ... Cochran AG, et al. A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of Medicinal Chemistry. 51: 4465-75. PMID 18630890 DOI: 10.1021/Jm800052B |
0.312 |
|
| 2007 |
Bourhis E, Hymowitz SG, Cochran AG. The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin. The Journal of Biological Chemistry. 282: 35018-23. PMID 17881355 DOI: 10.1074/Jbc.M706233200 |
0.686 |
|
| 2006 |
Li B, Russell SJ, Compaan DM, Totpal K, Marsters SA, Ashkenazi A, Cochran AG, Hymowitz SG, Sidhu SS. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. Journal of Molecular Biology. 361: 522-36. PMID 16859704 DOI: 10.1016/J.Jmb.2006.06.042 |
0.5 |
|
| 2004 |
Kotz JD, Bond CJ, Cochran AG. Phage-display as a tool for quantifying protein stability determinants. European Journal of Biochemistry / Febs. 271: 1623-9. PMID 15096201 DOI: 10.1111/J.1432-1033.2004.04076.X |
0.716 |
|
| 2003 |
Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Biochemistry. 42: 5977-83. PMID 12755599 DOI: 10.1021/Bi034017G |
0.4 |
|
| 2003 |
Blandl T, Cochran AG, Skelton NJ. Turn stability in beta-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns. Protein Science : a Publication of the Protein Society. 12: 237-47. PMID 12538887 DOI: 10.1110/Ps.0228603 |
0.321 |
|
| 2003 |
Russell SJ, Blandl T, Skelton NJ, Cochran AG. Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair. Journal of the American Chemical Society. 125: 388-95. PMID 12517150 DOI: 10.1021/Ja028075L |
0.466 |
|
| 2003 |
Skelton NJ, Blandl T, Russell SJ, Starovasnik MA, Cochran AG. β‒hairpin polypeptides by design and selection Spectroscopy. 17: 213-230. DOI: 10.1155/2003/148024 |
0.481 |
|
| 2002 |
Sia SK, Carr PA, Cochran AG, Malashkevich VN, Kim PS. Short constrained peptides that inhibit HIV-1 entry. Proceedings of the National Academy of Sciences of the United States of America. 99: 14664-9. PMID 12417739 DOI: 10.1073/Pnas.232566599 |
0.477 |
|
| 2002 |
Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 17: 515-24. PMID 12387744 DOI: 10.1016/S1074-7613(02)00425-9 |
0.349 |
|
| 2002 |
Distefano MD, Zhong A, Cochran AG. Quantifying beta-sheet stability by phage display. Journal of Molecular Biology. 322: 179-88. PMID 12215423 DOI: 10.1016/S0022-2836(02)00738-6 |
0.334 |
|
| 2002 |
Skelton NJ, Russell S, de Sauvage F, Cochran AG. Amino acid determinants of beta-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library. Journal of Molecular Biology. 316: 1111-25. PMID 11884148 DOI: 10.1006/Jmbi.2002.5410 |
0.476 |
|
| 2002 |
Pan B, Li B, Russell SJ, Tom JY, Cochran AG, Fairbrother WJ. Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor. Journal of Molecular Biology. 316: 769-87. PMID 11866530 DOI: 10.1006/Jmbi.2001.5370 |
0.495 |
|
| 2002 |
Cochran AG. Protein-protein interfaces: mimics and inhibitors. Current Opinion in Chemical Biology. 5: 654-9. PMID 11738175 DOI: 10.1016/S1367-5931(01)00262-9 |
0.332 |
|
| 2002 |
Pan B, Li B, Russell S, Tom J, Cochran A, Fairbrother W. 1H, 13C, and 15N Chemical Shift Assignments for v107 in complex with vascular endothelial growth factor Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5198 |
0.4 |
|
| 2001 |
Cochran AG, Tong RT, Starovasnik MA, Park EJ, McDowell RS, Theaker JE, Skelton NJ. A minimal peptide scaffold for beta-turn display: optimizing a strand position in disulfide-cyclized beta-hairpins. Journal of the American Chemical Society. 123: 625-32. PMID 11456574 DOI: 10.1021/Ja003369X |
0.325 |
|
| 2001 |
Skelton NJ, Chen YM, Dubree N, Quan C, Jackson DY, Cochran A, Zobel K, Deshayes K, Baca M, Pisabarro MT, Lowman HB. Structure−Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1‡ Biochemistry. 40: 8487-8498. PMID 11456486 DOI: 10.1021/Bi0103866 |
0.311 |
|
| 2001 |
Cochran AG, Skelton NJ, Starovasnik MA. Tryptophan zippers: stable, monomeric beta -hairpins. Proceedings of the National Academy of Sciences of the United States of America. 98: 5578-83. PMID 11331745 DOI: 10.1073/Pnas.091100898 |
0.308 |
|
| 2000 |
Cochran AG. Antagonists of protein-protein interactions. Chemistry & Biology. 7: R85-94. PMID 10779412 DOI: 10.1016/S1074-5521(00)00106-X |
0.314 |
|
| 1998 |
Wiesmann C, Christinger HW, Cochran AG, Cunningham BC, Fairbrother WJ, Keenan CJ, Meng G, De Vos AM. Crystal structure of the complex between VEGF and a receptor-blocking peptide Biochemistry. 37: 17765-17772. PMID 9922142 DOI: 10.1021/Bi9819327 |
0.357 |
|
| 1998 |
Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JYK, Wells JA, Cunningham BC. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site Biochemistry. 37: 17754-17764. PMID 9922141 DOI: 10.1021/Bi981931E |
0.336 |
|
| 1998 |
Singh M, Berger B, Kim PS, Berger JM, Cochran AG. Computational learning reveals coiled coil-like motifs in histidine kinase linker domains. Proceedings of the National Academy of Sciences of the United States of America. 95: 2738-43. PMID 9501159 DOI: 10.1073/Pnas.95.6.2738 |
0.479 |
|
| 1996 |
Cochran AG, Kim PS. Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain Science. 271: 1113-1116. PMID 8599087 DOI: 10.1126/Science.271.5252.1113 |
0.415 |
|
| 1995 |
Jacobsen JR, Cochran AG, Stephans JC, King DS, Schultz PG. Mechanistic Studies of Antibody-Catalyzed Pyrimidine Dimer Photocleavage Journal of the American Chemical Society. 117: 5453-5461. DOI: 10.1021/Ja00125A004 |
0.431 |
|
| 1991 |
Cochran AG, Pham T, Sugasawara R, Schultz PG. Antibody-catalyzed bimolecular imine formation Journal of the American Chemical Society. 113: 6670-6672. DOI: 10.1021/Ja00017A046 |
0.41 |
|
| 1990 |
Cochran AG, Schultz PG. Antibody-catalyzed porphyrin metallation. Science (New York, N.Y.). 249: 781-3. PMID 2389144 DOI: 10.1126/Science.2389144 |
0.328 |
|
| 1990 |
Cochran AG, Schultz PG. Peroxidase activity of an antibody-heme complex Journal of the American Chemical Society. 112: 9414-9415. DOI: 10.1021/Ja00181A065 |
0.444 |
|
| 1989 |
COCHRAN AG, SUGASAWARA R, SCHULTZ PG. ChemInform Abstract: Photosensitized Cleavage of a Thymine Dimer by an Antibody. Cheminform. 20. DOI: 10.1002/chin.198909321 |
0.339 |
|
| 1988 |
Cochran AG, Sugasawara R, Schultz PG. Photosensitized cleavage of a thymine dimer by an antibody Journal of the American Chemical Society. 110: 7888-7890. DOI: 10.1021/Ja00231A056 |
0.339 |
|
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