William G. Gutheil - Publications

Affiliations: 
Pharmaceutical Science University of Missouri - Kansas City, USA 
Area:
Pharmacy, Analytical Chemistry

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mishra NR, Sharma AD, Gargvanshi S, Gutheil WG. Deconvolution of multichannel LC-MS/MS chromatograms of glucosamine-phosphates: Evidence of a GlmS regulatory difference between and . Talanta Open. 8. PMID 38187186 DOI: 10.1016/j.talo.2023.100241  0.76
2023 Gargvanshi S, Heravi G, Ayon NJ, Gutheil WG. Screening the NCI diversity set V for anti-MRSA activity: cefoxitin synergy and LC-MS/MS confirmation of folate/thymidine biosynthesis inhibition. Microbiology Spectrum. e0054123. PMID 37888993 DOI: 10.1128/spectrum.00541-23  0.764
2023 Punchihewa BT, Minda V, Gutheil WG, Rafiee M. Electrosynthesis and Microanalysis in Thin Layer: An Electrochemical Pipette for Rapid Electrolysis and Mechanistic Study of Electrochemical Reactions. Angewandte Chemie (International Ed. in English). e202312048. PMID 37669353 DOI: 10.1002/anie.202312048  0.741
2022 Sharma AD, Gutheil WG. Synergistic Combinations of FDA-Approved Drugs with Ceftobiprole against Methicillin-Resistant Staphylococcus aureus. Microbiology Spectrum. e0372622. PMID 36519895 DOI: 10.1128/spectrum.03726-22  0.653
2022 Gargvanshi S, Gutheil WG. Library Screening for Synergistic Combinations of FDA-Approved Drugs and Metabolites with Vancomycin against VanA-Type Vancomycin-Resistant Enterococcus faecium. Microbiology Spectrum. e0141222. PMID 35969069 DOI: 10.1128/spectrum.01412-22  0.774
2021 Ayon NJ, Gutheil WG. Correction to "Dimensionally Enhanced Antibacterial Library Screening". Acs Chemical Biology. PMID 34324290 DOI: 10.1021/acschembio.1c00435  0.732
2021 Gargvanshi S, Vemula H, Gutheil WG. Effect of vancomycin on cytoplasmic peptidoglycan intermediates and operon mRNA levels in VanA-type vancomycin resistant . Journal of Bacteriology. JB0023021. PMID 34060906 DOI: 10.1128/JB.00230-21  0.774
2020 Dey AS, Ayon NJ, Bhattacharya C, Gutheil WG, Mukherji M. Positive/negative ion-switching-based LC-MS/MS method for quantification of cytosine derivatives produced by the TET-family 5-methylcytosine dioxygenases. Biology Methods & Protocols. 5: bpaa019. PMID 33376805 DOI: 10.1093/biomethods/bpaa019  0.774
2020 Massa SM, Sharma AD, Siletti C, Tu Z, Godfrey JJ, Gutheil WG, Huynh TN. C-di-AMP accumulation impairs muropeptide synthesis in . Journal of Bacteriology. PMID 33020220 DOI: 10.1128/JB.00307-20  0.678
2020 Gargvanshi S, Gutheil W. Effect of Vancomycin on Cytoplasmic Peptidoglycan Intermediate Levels in Vancomycin Resistant Enterococci. The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00731  0.3
2019 Ayon NJ, Gutheil WG. Dimensionally Enhanced Antibacterial Library Screening. Acs Chemical Biology. PMID 31675203 DOI: 10.1021/Acschembio.9B00745  0.771
2018 Ayon NJ, Sharma AD, Gutheil WG. LC-MS/MS-Based Separation and Quantification of Marfey's Reagent Derivatized Proteinogenic Amino Acid DL-Stereoisomers. Journal of the American Society For Mass Spectrometry. PMID 30421361 DOI: 10.1007/S13361-018-2093-9  0.789
2018 Bhattacharya C, Dey AS, Ayon NJ, Gutheil WG, Mukherji M. Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase. Journal of Visualized Experiments : Jove. PMID 30371677 DOI: 10.3791/57798  0.783
2018 Kitase Y, Vallejo JA, Gutheil W, Vemula H, Jähn K, Yi J, Zhou J, Brotto M, Bonewald LF. β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. Cell Reports. 22: 1531-1544. PMID 29425508 DOI: 10.1016/J.Celrep.2018.01.041  0.755
2017 Vemula H, Ayon NJ, Burton A, Gutheil WG. Antibiotic Effects on Methicillin Resistant Staphylococcus aureus Cytoplasmic Peptidoglycan Intermediate Levels; Evidence for Potential Metabolite Level Regulatory Loops. Antimicrobial Agents and Chemotherapy. PMID 28320719 DOI: 10.1128/Aac.02253-16  0.776
2017 Jaiswal M, Bhar S, Vemula H, Prakash S, Ponnaluri VK, Gutheil WG, Mukherji M. Convenient expression, purification and quantitative liquid chromatography-tandem mass spectrometry-based analysis of TET2 5-methylcytosine demethylase. Protein Expression and Purification. PMID 28188826 DOI: 10.1016/J.Pep.2017.02.003  0.777
2016 Vemula H, Kitase Y, Ayon NJ, Bonewald L, Gutheil WG. Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers. Analytical Biochemistry. 516: 75-85. PMID 27771391 DOI: 10.1016/J.Ab.2016.10.017  0.787
2016 Vemula H, Ayon NJ, Gutheil WG. Cytoplasmic peptidoglycan intermediate levels in Staphylococcus aureus. Biochimie. 121: 72-8. PMID 26612730 DOI: 10.1016/J.Biochi.2015.11.017  0.797
2015 Rangarajan P, Subramaniam D, Paul S, Kwatra D, Palaniyandi K, Islam S, Harihar S, Ramalingam S, Gutheil W, Putty S, Pradhan R, Padhye S, Welch DR, Anant S, Dhar A. Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells. Oncotarget. 6: 27661-73. PMID 26317547 DOI: 10.18632/Oncotarget.4871  0.759
2014 Vemula H, Bobba S, Putty S, Barbara JE, Gutheil WG. Ion-pairing liquid chromatography-tandem mass spectrometry-based quantification of uridine diphosphate-linked intermediates in the Staphylococcus aureus cell wall biosynthesis pathway. Analytical Biochemistry. 465: 12-9. PMID 25086364 DOI: 10.1016/J.Ab.2014.07.024  0.776
2013 Putty S, Vemula H, Bobba S, Gutheil WG. A liquid chromatography-tandem mass spectrometry assay for d-Ala-d-Lac: a key intermediate for vancomycin resistance in vancomycin-resistant enterococci. Analytical Biochemistry. 442: 166-71. PMID 23938774 DOI: 10.1016/J.Ab.2013.07.045  0.763
2012 Bobba S, Resch GE, Gutheil WG. A liquid chromatography-tandem mass spectrometry assay for detection and quantitation of the dipeptide Gly-Gln in rat brain. Analytical Biochemistry. 425: 145-50. PMID 22446498 DOI: 10.1016/J.Ab.2012.03.007  0.795
2011 Putty S, Rai A, Jamindar D, Pagano P, Quinn CL, Mima T, Schweizer HP, Gutheil WG. Characterization of d-boroAla as a novel broad-spectrum antibacterial agent targeting d-Ala-d-Ala ligase. Chemical Biology & Drug Design. 78: 757-63. PMID 21827632 DOI: 10.1111/J.1747-0285.2011.01210.X  0.8
2011 Bobba S, Gutheil WG. Multivariate geometrical analysis of catalytic residues in the penicillin-binding proteins. The International Journal of Biochemistry & Cell Biology. 43: 1490-9. PMID 21740978 DOI: 10.1016/J.Biocel.2011.06.012  0.774
2011 Bobba S, Ponnaluri VK, Mukherji M, Gutheil WG. Microtiter plate-based assay for inhibitors of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 55: 2783-7. PMID 21402836 DOI: 10.1128/Aac.01327-10  0.779
2011 Aurora C, Gutheil WG, Reed G, Anant S, Dhar A. Abstract 4609: Prevention of pancreatic cancer using novel crocetin compound Cancer Research. 71: 4609-4609. DOI: 10.1158/1538-7445.Am2011-4609  0.314
2010 Stefanova M, Bobba S, Gutheil WG. A microtiter plate-based beta-lactam binding assay for inhibitors of high-molecular-mass penicillin-binding proteins. Analytical Biochemistry. 396: 164-6. PMID 19748471 DOI: 10.1016/J.Ab.2009.09.004  0.77
2010 Jamindar D, Gutheil WG. A liquid chromatography-tandem mass spectrometry assay for Marfey's derivatives of L-Ala, D-Ala, and D-Ala-D-Ala: application to the in vivo confirmation of alanine racemase as the target of cycloserine in Escherichia coli. Analytical Biochemistry. 396: 1-7. PMID 19748470 DOI: 10.1016/J.Ab.2009.09.006  0.496
2009 Ponnaluri VK, Vavilala DT, Putty S, Gutheil WG, Mukherji M. Identification of non-histone substrates for JMJD2A-C histone demethylases. Biochemical and Biophysical Research Communications. 390: 280-4. PMID 19799855 DOI: 10.1016/J.Bbrc.2009.09.107  0.75
2009 Peddi S, Nicholas RA, Gutheil WG. Neisseria gonorrhoeae penicillin-binding protein 3 demonstrates a pronounced preference for N(epsilon)-acylated substrates. Biochemistry. 48: 5731-7. PMID 19413336 DOI: 10.1021/Bi9003099  0.414
2005 Nicola G, Peddi S, Stefanova M, Nicholas RA, Gutheil WG, Davies C. Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: a role for Ser-110 in deacylation. Biochemistry. 44: 8207-17. PMID 15938610 DOI: 10.1021/Bi0473004  0.321
2004 Stefanova ME, Tomberg J, Davies C, Nicholas RA, Gutheil WG. Overexpression and enzymatic characterization of Neisseria gonorrhoeae penicillin-binding protein 4. European Journal of Biochemistry / Febs. 271: 23-32. PMID 14686916 DOI: 10.1046/J.1432-1033.2003.03886.X  0.413
2003 Stefanova ME, Tomberg J, Olesky M, Höltje JV, Gutheil WG, Nicholas RA. Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities. Biochemistry. 42: 14614-25. PMID 14661974 DOI: 10.1021/Bi0350607  0.353
2003 Pechenov A, Stefanova ME, Nicholas RA, Peddi S, Gutheil WG. Potential transition state analogue inhibitors for the penicillin-binding proteins. Biochemistry. 42: 579-88. PMID 12525187 DOI: 10.1021/Bi026726K  0.37
2002 Stefanova ME, Davies C, Nicholas RA, Gutheil WG. pH, inhibitor, and substrate specificity studies on Escherichia coli penicillin-binding protein 5. Biochimica Et Biophysica Acta. 1597: 292-300. PMID 12044907 DOI: 10.1016/S0167-4838(02)00311-4  0.374
2000 Gutheil WG, Stefanova ME, Nicholas RA. Fluorescent coupled enzyme assays for D-Alanine: Application to penicillin-binding protein and vancomycin activity assays Analytical Biochemistry. 287: 196-202. PMID 11112264 DOI: 10.1006/Abio.2000.4835  0.418
1999 Krause SO, Gutheil WG, Simeonov AM, Matsunaga TO, Stauber MJ, Kenyon GL, Mckenna CE. Perspectives on the mechanism of ATP hydrolysis by nitrogenase Phosphorus, Sulfur and Silicon and Related Elements. 144: 513-516. DOI: 10.1080/10426509908546294  0.477
1998 Gutheil WG. A sensitive equilibrium-based assay for D-lactate using D-lactate dehydrogenase: application to penicillin-binding protein/DD-carboxypeptidase activity assays. Analytical Biochemistry. 259: 62-7. PMID 9606144 DOI: 10.1006/Abio.1998.2642  0.414
1996 Tsilikounas E, Rao T, Gutheil WG, Bachovchin WW. 15N and 1H NMR spectroscopy of the catalytic histidine in chloromethyl ketone-inhibited complexes of serine proteases Biochemistry. 35: 2437-2444. PMID 8652587 DOI: 10.1021/Bi9513968  0.593
1994 Sudmeier JL, Günther UL, Gutheil WG, Coutts SJ, Snow RJ, Barton RW, Bachovchin WW. Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy Biochemistry. 33: 12427-12438. PMID 7918465 DOI: 10.1021/Bi00207A009  0.63
1994 Gutheil WG, Subramanyam M, Flentke GR, Sanford DG, Munoz E, Huber BT, Bachovchin WW. Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity. Proceedings of the National Academy of Sciences of the United States of America. 91: 6594-8. PMID 7912830 DOI: 10.1073/Pnas.91.14.6594  0.59
1994 Gutheil WG, Kettner CA, Bachovchin WW. Kinlsq: A program for fitting kinetics data with numerically integrated rate equations and its application to the analysis of slow, tight-binding inhibition data Analytical Biochemistry. 223: 13-20. PMID 7695087 DOI: 10.1006/Abio.1994.1539  0.574
1994 Snow RJ, Bachovchin WW, Barton RW, Campbell SJ, Coutts SJ, Freeman DM, Gutheil WG, Kelly TA, Kennedy CA, Krolikowski DA, Leonard SF, Pargellis CA, Tong L, Adams J. Studies on proline boronic acid dipeptide inhibitors of dipeptidyl peptidase IV: Identification of a cyclic species containing a B-N bond Journal of the American Chemical Society. 116: 10860-10869. DOI: 10.1021/Ja00103A002  0.597
1993 Gutheil WG, Bachovchin WW. Separation of L-Pro-DL-boroPro into its component diastereomers and kinetic analysis of their inhibition of dipeptidyl peptidase IV. A new method for the analysis of slow, tight-binding inhibition Biochemistry. 32: 8723-8731. PMID 8103356 DOI: 10.1021/Bi00085A001  0.629
1993 Farr-Jones S, Wong WYL, Gutheil WG, Bachovchin WW. Direct observation of the tautomeric forms of histidine in 15N NMR spectra at low temperatures. Comments on intramolecular hydrogen bonding and on tautomeric equilibrium constants Journal of the American Chemical Society. 115: 6813-6819.  0.523
1992 Gutheil WG, Holmquist B, Vallee BL. Purification, characterization, and partial sequence of the glutathione-dependent formaldehyde dehydrogenase from Escherichia coli: A class III alcohol dehydrogenase Biochemistry. 31: 475-481. PMID 1731906 DOI: 10.1021/Bi00117A025  0.463
1992 Gutheil WG, McKenna CE. Unique and independent parameters (UIP) formulation for thermodynamic models of complex protein-ligand systems. Biophysical Chemistry. 45: 171-9. PMID 1286150 DOI: 10.1016/0301-4622(92)87009-8  0.496
1991 McKenna CE, Gutheil WG, Song W. A method for preparing analytically pure sodium dithionite. Dithionite quality and observed nitrogenase-specific activities. Biochimica Et Biophysica Acta. 1075: 109-17. PMID 1892862 DOI: 10.1016/0304-4165(91)90082-R  0.499
1989 McKenna CE, Gutheil WG, Kenyon GL, Matsunaga TO. Mass spectrometric analysis of phosphate from β,γ-[18O]ATP hydrolyzed by Azotobacter vinelandii nitrogenase: Direct evidence for PγOPβ bond cleavage Bioorganic Chemistry. 17: 377-384. DOI: 10.1016/0045-2068(89)90039-4  0.514
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