| Year |
Citation |
Score |
| 2023 |
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. Author Correction: A central role for JNK in obesity and insulin resistance. Nature. PMID 37328696 DOI: 10.1038/s41586-023-06285-0 |
0.362 |
|
| 2023 |
Inouye KE, Prentice KJ, Lee A, Wang ZB, Dominguez-Gonzalez C, Chen MX, Riveros JK, Burak MF, Lee GY, Hotamisligil GS. Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion. Jci Insight. PMID 37279064 DOI: 10.1172/jci.insight.164642 |
0.335 |
|
| 2023 |
Prentice KJ, Lee A, Cedillo P, Inouye KE, Ertunc ME, Riveros JK, Lee GY, Hotamisligil GS. Sympathetic tone dictates the impact of lipolysis on FABP4 secretion. Journal of Lipid Research. 100386. PMID 37172691 DOI: 10.1016/j.jlr.2023.100386 |
0.317 |
|
| 2023 |
Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS. Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity. Biorxiv : the Preprint Server For Biology. PMID 36865319 DOI: 10.1101/2023.02.21.528863 |
0.789 |
|
| 2022 |
Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 603: 736-742. PMID 35264794 DOI: 10.1038/s41586-022-04488-5 |
0.776 |
|
| 2021 |
Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca signaling by IPRs in adipocytes links inflammation to metabolic dysregulation in obesity. Science Signaling. 14: eabf2059. PMID 34905386 DOI: 10.1126/scisignal.abf2059 |
0.798 |
|
| 2021 |
Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS. A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. PMID 34880500 DOI: 10.1038/s41586-021-04137-3 |
0.792 |
|
| 2021 |
Sethi JK, Hotamisligil GS. Metabolic Messengers: tumour necrosis factor. Nature Metabolism. 3: 1302-1312. PMID 34650277 DOI: 10.1038/s42255-021-00470-z |
0.381 |
|
| 2021 |
Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metabolism. 33: 1716. PMID 34348100 DOI: 10.1016/j.cmet.2021.07.005 |
0.813 |
|
| 2020 |
Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metabolism. PMID 33340456 DOI: 10.1016/j.cmet.2020.11.009 |
0.828 |
|
| 2020 |
Zhang Z, Qian Q, Li M, Shao F, Ding WX, Lira VA, Chen SX, Sebag SC, Hotamisligil GS, Cao H, Yang L. The Unfolded Protein Response Regulates Hepatic Autophagy by sXBP1-mediated Activation of TFEB. Autophagy. PMID 32597296 DOI: 10.1080/15548627.2020.1788889 |
0.411 |
|
| 2019 |
Goncalves RLS, Hotamisligil GS. TMEM2 Modulates ER Stress in a Non-canonical Manner. Cell Metabolism. 30: 999-1001. PMID 31801059 DOI: 10.1016/J.Cmet.2019.11.008 |
0.317 |
|
| 2019 |
Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, ... ... Hotamisligil GS, et al. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metabolism. PMID 31353262 DOI: 10.1016/J.Cmet.2019.07.001 |
0.446 |
|
| 2019 |
Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, ... Hotamisligil GS, et al. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science Translational Medicine. 11. PMID 31019023 DOI: 10.1126/Scitranslmed.Aav0120 |
0.802 |
|
| 2019 |
Prentice KJ, Saksi J, Hotamisligil GS. Adipokine FABP4 integrates energy stores and counter regulatory metabolic responses. Journal of Lipid Research. PMID 30705117 DOI: 10.1194/Jlr.S091793 |
0.467 |
|
| 2019 |
Burak MF, Dagtekin N, Bejo P, Vaillancourt E, Liu L, Gorgun C, Rimm E, Tuncman G, Hotamisligil G. OR01-1 Leveraging Immunometabolic Control to Prevent and Treat Obesity Related Asthma Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Or01-1 |
0.359 |
|
| 2018 |
Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M. TACI Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis. Diabetes. PMID 29871859 DOI: 10.2337/Db17-1089 |
0.522 |
|
| 2018 |
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, ... ... Hotamisligil GS, et al. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nature Medicine. PMID 29400713 DOI: 10.1038/Nm.4481 |
0.817 |
|
| 2017 |
Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity. Elife. 6. PMID 29243589 DOI: 10.7554/Elife.29968 |
0.81 |
|
| 2017 |
Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS. NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 171: 1094-1109.e15. PMID 29149604 DOI: 10.1016/J.Cell.2017.10.003 |
0.323 |
|
| 2017 |
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, ... ... Hotamisligil GS, et al. Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature Medicine. 23: 1384. PMID 29117173 DOI: 10.1038/Nm1117-1384B |
0.32 |
|
| 2017 |
Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Reports. 21: 393-402. PMID 29020626 DOI: 10.1016/J.Celrep.2017.09.051 |
0.448 |
|
| 2017 |
Hotamisligil GS. Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity. 47: 406-420. PMID 28930657 DOI: 10.1016/J.Immuni.2017.08.009 |
0.402 |
|
| 2017 |
Garfinkel BP, Hotamisligil GS. ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity. Molecular Cell. 66: 731-733. PMID 28622517 DOI: 10.1016/J.Molcel.2017.05.037 |
0.477 |
|
| 2017 |
Parlakgul G, Hotamisligil GS. Type I Interferons Interfere with Liver Glucose Metabolism. Cell Metabolism. 25: 1211-1212. PMID 28591628 DOI: 10.1016/J.Cmet.2017.05.009 |
0.813 |
|
| 2017 |
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, ... ... Hotamisligil GS, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature Medicine. PMID 28346411 DOI: 10.1038/Nm.4297 |
0.486 |
|
| 2017 |
Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. PMID 28219080 DOI: 10.1038/Nature21379 |
0.583 |
|
| 2017 |
Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 542: 177-185. PMID 28179656 DOI: 10.1038/Nature21363 |
0.372 |
|
| 2017 |
Pan Y, Tian T, Park C, Lofftus S, Mei S, Liu X, Luo C, O'Malley J, Gehad A, Teague J, Divito S, Fuhlbrigge R, Puigserver P, Krueger J, Hotamisligil G, et al. 055 Tissue resident memory T cell survival requires exogenous lipid uptake and metabolism Journal of Investigative Dermatology. 137: S10. DOI: 10.1016/J.Jid.2017.02.068 |
0.589 |
|
| 2016 |
Widenmaier SB, Hotamışlıgil GS. Immune Cell Intolerance for Excess Cholesterol. Immunity. 45: 1186-1188. PMID 28002726 DOI: 10.1016/J.Immuni.2016.12.006 |
0.318 |
|
| 2016 |
Hotamisligil GS, Davis RJ. Cell Signaling and Stress Responses. Cold Spring Harbor Perspectives in Biology. 8. PMID 27698029 DOI: 10.1101/Cshperspect.A006072 |
0.415 |
|
| 2016 |
Çimen I, Kocatürk B, Koyuncu S, Tufanlı Ö, Onat UI, Yıldırım AD, Apaydın O, Demirsoy Ş, Aykut ZG, Nguyen UT, Watkins SM, Hotamışlıgil GS, Erbay E. Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Science Translational Medicine. 8: 358ra126. PMID 27683551 DOI: 10.1126/Scitranslmed.Aaf9087 |
0.475 |
|
| 2016 |
Erikci Ertunc M, Hotamisligil GS. Lipid signaling and lipotoxicity in metabolic inflammation: indications for metabolic disease pathogenesis and treatment. Journal of Lipid Research. PMID 27330055 DOI: 10.1194/Jlr.R066514 |
0.446 |
|
| 2016 |
Yilmaz M, Claiborn KC, Hotamisligil GS. De Novo Lipogenesis Products and Endogenous Lipokines. Diabetes. PMID 27288005 DOI: 10.2337/Db16-0251 |
0.387 |
|
| 2016 |
Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF. Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27102962 DOI: 10.1161/Atvbaha.116.307580 |
0.337 |
|
| 2015 |
Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, ... ... Hotamisligil GS, et al. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Science Translational Medicine. 7: 319ra205. PMID 26702093 DOI: 10.1126/Scitranslmed.Aac6336 |
0.804 |
|
| 2015 |
Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. PMID 26625874 DOI: 10.1007/S10456-015-9491-4 |
0.357 |
|
| 2015 |
Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, et al. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metabolism. PMID 26481668 DOI: 10.1016/J.Cmet.2015.09.013 |
0.467 |
|
| 2015 |
Hotamisligil GS, Bernlohr DA. Metabolic functions of FABPs-mechanisms and therapeutic implications. Nature Reviews. Endocrinology. 11: 592-605. PMID 26260145 DOI: 10.1038/Nrendo.2015.122 |
0.438 |
|
| 2015 |
Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS. METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science (New York, N.Y.). 349: 500-6. PMID 26228140 DOI: 10.1126/Science.Aaa0079 |
0.829 |
|
| 2015 |
Arruda AP, Hotamisligil GS. Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metabolism. 22: 381-97. PMID 26190652 DOI: 10.1016/J.Cmet.2015.06.010 |
0.499 |
|
| 2015 |
Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, Bugliani M, Engin F, Hotamisligil GS, Marchetti P, Eizirik DL. Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms. Diabetologia. 58: 2307-16. PMID 26099855 DOI: 10.1007/S00125-015-3669-6 |
0.324 |
|
| 2015 |
Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Science Translational Medicine. 7: 292ra98. PMID 26084805 DOI: 10.1126/Scitranslmed.Aaa9134 |
0.452 |
|
| 2015 |
Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BL. Potential role for snoRNAs in PKR activation during metabolic stress. Proceedings of the National Academy of Sciences of the United States of America. 112: 5023-8. PMID 25848059 DOI: 10.1073/Pnas.1424044112 |
0.335 |
|
| 2015 |
Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS. A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity. Cell Reports. 11: 295-307. PMID 25843719 DOI: 10.1016/J.Celrep.2015.03.021 |
0.532 |
|
| 2015 |
Ertunc ME, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, Saatcioglu F, Hotamisligil GS. Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. Journal of Lipid Research. 56: 423-34. PMID 25535287 DOI: 10.1194/Jlr.M055798 |
0.429 |
|
| 2014 |
Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nature Medicine. 20: 1427-35. PMID 25419710 DOI: 10.1038/Nm.3735 |
0.805 |
|
| 2014 |
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 513: 440-3. PMID 25043031 DOI: 10.1038/Nature13492 |
0.327 |
|
| 2014 |
Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. Aberrant islet unfolded protein response in type 2 diabetes. Scientific Reports. 4: 4054. PMID 24514745 DOI: 10.1038/Srep04054 |
0.417 |
|
| 2014 |
Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein M. FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes. 63: 900-11. PMID 24319114 DOI: 10.2337/Db13-0436 |
0.527 |
|
| 2014 |
Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS. Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes. 63: 526-34. PMID 24150608 DOI: 10.2337/Db13-1019 |
0.522 |
|
| 2013 |
Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, ... ... Hotamisligil GS, et al. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. Plos One. 8: e79386. PMID 24244493 DOI: 10.1371/Journal.Pone.0079386 |
0.434 |
|
| 2013 |
Engin F, Yermalovich A, Nguyen T, Ngyuen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Science Translational Medicine. 5: 211ra156. PMID 24225943 DOI: 10.1126/Scitranslmed.3006534 |
0.428 |
|
| 2013 |
Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 502: 550-4. PMID 24153306 DOI: 10.1038/Nature12710 |
0.413 |
|
| 2013 |
Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metabolism. 17: 768-78. PMID 23663740 DOI: 10.1016/J.Cmet.2013.04.012 |
0.447 |
|
| 2013 |
Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Reports. 3: 1430-9. PMID 23623498 DOI: 10.1016/J.Celrep.2013.03.042 |
0.49 |
|
| 2013 |
Calay ES, Hotamisligil GS. Turning off the inflammatory, but not the metabolic, flames. Nature Medicine. 19: 265-7. PMID 23467233 DOI: 10.1038/Nm.3114 |
0.827 |
|
| 2013 |
Yalcin A, Hotamisligil GS. Impact of ER protein homeostasis on metabolism. Diabetes. 62: 691-3. PMID 23431011 DOI: 10.2337/Db12-1526 |
0.312 |
|
| 2013 |
Mozaffarian D, De Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, Siscovick DS, Nettleton JA. Trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: The multi-ethnic study of atherosclerosis (MESA) American Journal of Clinical Nutrition. 97: 854-861. PMID 23407305 DOI: 10.3945/Ajcn.112.045468 |
0.302 |
|
| 2013 |
Yilmaz M, Hotamisligil GS. Damned if you do, damned if you don't: the conundrum of adipose tissue vascularization. Cell Metabolism. 17: 7-9. PMID 23312279 DOI: 10.1016/J.Cmet.2012.12.014 |
0.384 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Hotamisligil GS, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.553 |
|
| 2012 |
Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GS. Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. Plos Genetics. 8: e1002902. PMID 22927828 DOI: 10.1371/Journal.Pgen.1002902 |
0.537 |
|
| 2012 |
ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamisligil GS. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metabolism. 16: 81-9. PMID 22704678 DOI: 10.1016/J.Cmet.2012.05.009 |
0.786 |
|
| 2012 |
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proceedings of the National Academy of Sciences of the United States of America. 109: E1868-77. PMID 22699504 DOI: 10.1073/Pnas.1116889109 |
0.426 |
|
| 2012 |
Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: Role of stem cell factor/c-kit pathway Angiogenesis. 15: 457-468. PMID 22562362 DOI: 10.1007/S10456-012-9274-0 |
0.347 |
|
| 2012 |
Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metabolism. 15: 623-34. PMID 22560215 DOI: 10.1016/J.Cmet.2012.03.007 |
0.483 |
|
| 2012 |
Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. The Journal of Biological Chemistry. 287: 6025-34. PMID 22215663 DOI: 10.1074/Jbc.M111.311217 |
0.347 |
|
| 2011 |
Furuhashi M, Ishimura S, Ota H, Hayashi M, Nishitani T, Tanaka M, Yoshida H, Shimamoto K, Hotamisligil GS, Miura T. Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. Plos One. 6: e27356. PMID 22102888 DOI: 10.1371/Journal.Pone.0027356 |
0.353 |
|
| 2011 |
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metabolism. 14: 21-32. PMID 21723501 DOI: 10.1016/J.Cmet.2011.06.002 |
0.404 |
|
| 2011 |
Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH. Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 108: 8885-90. PMID 21555585 DOI: 10.1073/Pnas.1105564108 |
0.421 |
|
| 2011 |
Fu S, Yang L, Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 473: 528-31. PMID 21532591 DOI: 10.1038/nature09968 |
0.416 |
|
| 2011 |
Babaev VR, Runner RP, Fan D, Ding L, Zhang Y, Tao H, Erbay E, Görgün CZ, Fazio S, Hotamisligil GS, Linton MF. Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1283-90. PMID 21474828 DOI: 10.1161/Atvbaha.111.225839 |
0.38 |
|
| 2011 |
Horng T, Hotamisligil GS. Linking the inflammasome to obesity-related disease. Nature Medicine. 17: 164-5. PMID 21297609 DOI: 10.1038/Nm0211-164 |
0.476 |
|
| 2011 |
Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annual Review of Immunology. 29: 415-45. PMID 21219177 DOI: 10.1146/Annurev-Immunol-031210-101322 |
0.549 |
|
| 2010 |
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Annals of Internal Medicine. 153: 790-9. PMID 21173413 DOI: 10.7326/0003-4819-153-12-201012210-00005 |
0.386 |
|
| 2010 |
Vallerie SN, Hotamisligil GS. The role of JNK proteins in metabolism. Science Translational Medicine. 2: 60rv5. PMID 21123811 DOI: 10.1126/Scitranslmed.3001007 |
0.505 |
|
| 2010 |
Engin F, Hotamisligil GS. Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases. Diabetes, Obesity & Metabolism. 12: 108-15. PMID 21029307 DOI: 10.1111/J.1463-1326.2010.01282.X |
0.386 |
|
| 2010 |
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. The American Journal of Clinical Nutrition. 92: 1350-8. PMID 20943795 DOI: 10.3945/Ajcn.110.003970 |
0.396 |
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| 2010 |
Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circulation Research. 107: 579-91. PMID 20814028 DOI: 10.1161/Circresaha.110.225698 |
0.49 |
|
| 2010 |
Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S. Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 59: 1899-905. PMID 20522594 DOI: 10.2337/Db10-0308 |
0.387 |
|
| 2010 |
Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism. 11: 467-78. PMID 20519119 DOI: 10.1016/J.Cmet.2010.04.005 |
0.829 |
|
| 2010 |
Li P, Hotamisligil GS. Metabolism: Host and microbes in a pickle. Nature. 464: 1287-8. PMID 20428156 DOI: 10.1038/4641287A |
0.432 |
|
| 2010 |
Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nature Medicine. 16: 396-9. PMID 20376052 DOI: 10.1038/Nm0410-396 |
0.467 |
|
| 2010 |
Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 140: 900-17. PMID 20303879 DOI: 10.1016/J.Cell.2010.02.034 |
0.493 |
|
| 2010 |
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 140: 338-48. PMID 20144759 DOI: 10.1016/J.Cell.2010.01.001 |
0.536 |
|
| 2010 |
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults Annals of Internal Medicine. 153: 790-799. DOI: 10.1059/0003-4819-153-12-201012210-00005 |
0.329 |
|
| 2010 |
Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Erratum: Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis Nature Medicine. 16: 237-237. DOI: 10.1038/Nm0210-237C |
0.322 |
|
| 2010 |
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Erratum: Corrigendum: Neuronal PTP1B regulates body weight, adiposity and leptin action Nature Medicine. 16: 237-237. DOI: 10.1038/Nm0210-237A |
0.301 |
|
| 2009 |
Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Medicine. 15: 1383-91. PMID 19966778 DOI: 10.1038/Nm.2067 |
0.396 |
|
| 2009 |
Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nature Medicine. 15: 940-5. PMID 19633655 DOI: 10.1038/Nm.1994 |
0.483 |
|
| 2009 |
Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, ... ... Hotamisligil GS, et al. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metabolism. 9: 339-49. PMID 19356715 DOI: 10.1016/J.Cmet.2009.03.002 |
0.504 |
|
| 2009 |
Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes. 58: 693-700. PMID 19066313 DOI: 10.2337/Db08-1220 |
0.518 |
|
| 2009 |
Peraldi P, Hotamisligil GS, Buurman WA, White M, Spiegelman BM. O-47: Mechanisms of TNF-α induced insulin resistance Experimental and Clinical Endocrinology & Diabetes. 104: 59-59. DOI: 10.1055/s-0029-1211538 |
0.467 |
|
| 2008 |
Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. International Journal of Obesity (2005). 32: S52-4. PMID 19136991 DOI: 10.1038/Ijo.2008.238 |
0.544 |
|
| 2008 |
Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nature Reviews. Immunology. 8: 923-34. PMID 19029988 DOI: 10.1038/Nri2449 |
0.387 |
|
| 2008 |
Yang L, Hotamisligil GS. Stressing the brain, fattening the body. Cell. 135: 20-2. PMID 18854151 DOI: 10.1016/J.Cell.2008.09.030 |
0.409 |
|
| 2008 |
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 134: 933-44. PMID 18805087 DOI: 10.1016/J.Cell.2008.07.048 |
0.456 |
|
| 2008 |
Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. Plos One. 3: e3151. PMID 18773087 DOI: 10.1371/Journal.Pone.0003151 |
0.482 |
|
| 2008 |
Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. The Journal of Clinical Investigation. 118: 2640-50. PMID 18551191 DOI: 10.1172/Jci34750 |
0.531 |
|
| 2008 |
Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nature Reviews. Drug Discovery. 7: 489-503. PMID 18511927 DOI: 10.1038/Nrd2589 |
0.427 |
|
| 2008 |
Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell. 29: 541-51. PMID 18342602 DOI: 10.1016/J.Molcel.2007.12.023 |
0.427 |
|
| 2007 |
Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. Novartis Foundation Symposium. 286: 86-94; discussion 94. PMID 18269176 DOI: 10.1002/9780470985571.Ch8 |
0.579 |
|
| 2007 |
Erbay E, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome. Current Atherosclerosis Reports. 9: 222-9. PMID 18241617 DOI: 10.1007/S11883-007-0023-6 |
0.466 |
|
| 2007 |
Gregor MF, Hotamisligil GS. Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. Journal of Lipid Research. 48: 1905-14. PMID 17699733 DOI: 10.1194/Jlr.R700007-Jlr200 |
0.543 |
|
| 2007 |
Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 179: 313-21. PMID 17579051 DOI: 10.4049/Jimmunol.179.1.313 |
0.391 |
|
| 2007 |
Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 447: 959-65. PMID 17554340 DOI: 10.1038/Nature05844 |
0.408 |
|
| 2007 |
Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell. 129: 537-48. PMID 17482547 DOI: 10.1016/J.Cell.2007.02.049 |
0.48 |
|
| 2007 |
Li P, Carling D, Hotamisligil GS, Bernlohr DA, Attie AD, Kim JB, Spiegelman BM. Discussion Novartis Foundation Symposium. 286: 81-85. |
0.345 |
|
| 2006 |
Hotamisligil GS. Inflammation and metabolic disorders. Nature. 444: 860-7. PMID 17167474 DOI: 10.1038/Nature05485 |
0.419 |
|
| 2006 |
Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism. 4: 465-74. PMID 17141630 DOI: 10.1016/J.Cmet.2006.11.005 |
0.468 |
|
| 2006 |
Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear LJ. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochemical and Biophysical Research Communications. 350: 1063-8. PMID 17045576 DOI: 10.1016/J.Bbrc.2006.09.158 |
0.385 |
|
| 2006 |
Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology. 131: 934-45. PMID 16952562 DOI: 10.1053/J.Gastro.2006.05.054 |
0.449 |
|
| 2006 |
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (New York, N.Y.). 313: 1137-40. PMID 16931765 DOI: 10.1126/Science.1128294 |
0.492 |
|
| 2006 |
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine. 12: 917-24. PMID 16845389 DOI: 10.1038/Nm1435 |
0.465 |
|
| 2006 |
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 103: 10741-6. PMID 16818881 DOI: 10.1073/Pnas.0603509103 |
0.527 |
|
| 2006 |
Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 55: 1915-22. PMID 16804058 DOI: 10.2337/Db05-1496 |
0.502 |
|
| 2006 |
Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 6970-5. PMID 16641093 DOI: 10.1073/Pnas.0602178103 |
0.44 |
|
| 2006 |
Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metabolism. 3: 247-56. PMID 16581002 DOI: 10.1016/J.Cmet.2006.02.010 |
0.42 |
|
| 2006 |
Neels JG, Pandey M, Hotamisligil GS, Samad F. Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. The American Journal of Pathology. 168: 435-44. PMID 16436658 DOI: 10.2353/Ajpath.2006.050699 |
0.344 |
|
| 2006 |
Baumgartl J, Baudler S, Scherner M, Babaev VR, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton MF, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) Cell Metabolism. 3: 469. DOI: 10.1016/J.Cmet.2006.05.008 |
0.378 |
|
| 2005 |
Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 54: S73-8. PMID 16306344 DOI: 10.2337/Diabetes.54.Suppl_2.S73 |
0.543 |
|
| 2005 |
Makowski L, Hotamisligil GS. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Current Opinion in Lipidology. 16: 543-8. PMID 16148539 DOI: 10.1097/01.Mol.0000180166.08196.07 |
0.491 |
|
| 2005 |
Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. Embo Reports. 6: 879-84. PMID 16082385 DOI: 10.1038/Sj.Embor.7400490 |
0.352 |
|
| 2005 |
Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metabolism. 1: 107-19. PMID 16054052 DOI: 10.1016/J.Cmet.2004.12.008 |
0.538 |
|
| 2005 |
Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. The Journal of Clinical Investigation. 115: 1111-9. PMID 15864338 DOI: 10.1172/Jci25102 |
0.502 |
|
| 2004 |
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (New York, N.Y.). 306: 457-61. PMID 15486293 DOI: 10.1126/Science.1103160 |
0.503 |
|
| 2004 |
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 110: 1492-8. PMID 15353487 DOI: 10.1161/01.Cir.0000141735.13202.B6 |
0.46 |
|
| 2004 |
Makowski L, Hotamisligil GS. Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. The Journal of Nutrition. 134: 2464S-2468S. PMID 15333743 DOI: 10.1093/Jn/134.9.2464S |
0.39 |
|
| 2004 |
Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology. 145: 2214-20. PMID 14764635 DOI: 10.1210/En.2003-1580 |
0.418 |
|
| 2003 |
Hotamisligil GS. Inflammatory pathways and insulin action. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 27: S53-5. PMID 14704746 DOI: 10.1038/Sj.Ijo.0802502 |
0.542 |
|
| 2003 |
Tong Q, Tsai J, Hotamisligil GS. GATA transcription factors and fat cell formation. Drug News & Perspectives. 16: 585-8. PMID 14702139 DOI: 10.1358/Dnp.2003.16.9.829340 |
0.309 |
|
| 2003 |
Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. The Journal of Clinical Investigation. 112: 1785-8. PMID 14679172 DOI: 10.1172/Jci20514 |
0.451 |
|
| 2003 |
Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obesity Research. 11: 1055-64. PMID 12972675 DOI: 10.1038/Oby.2003.145 |
0.412 |
|
| 2003 |
Pischon T, Hotamisligil GS, Rimm EB. Adiponectin: Stability in plasma over 36 hours and within-person variation over 1 year Clinical Chemistry. 49: 650-652. PMID 12651819 DOI: 10.1373/49.4.650 |
0.397 |
|
| 2003 |
Pandey M, Tuncman G, Hotamisligil GS, Samad F. Divergent roles for p55 and p75 TNF-α receptors in the induction of plasminogen activator inhibitor-1 American Journal of Pathology. 162: 933-941. PMID 12598326 DOI: 10.1016/S0002-9440(10)63888-6 |
0.367 |
|
| 2003 |
Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 52: 300-7. PMID 12540600 DOI: 10.2337/Diabetes.52.2.300 |
0.56 |
|
| 2003 |
Hotamisligil GS. The irresistible biology of resistin Journal of Clinical Investigation. 111: 173-174. PMID 12531870 DOI: 10.1172/Jci17605 |
0.509 |
|
| 2002 |
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature. 420: 333-6. PMID 12447443 DOI: 10.1038/Nature01137 |
0.518 |
|
| 2002 |
Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 1686-1691. PMID 12377750 DOI: 10.1161/01.Atv.0000033090.81345.E6 |
0.404 |
|
| 2002 |
Fisher RM, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M. Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue International Journal of Obesity. 26: 1379-1385. PMID 12355335 DOI: 10.1038/Sj.Ijo.0802110 |
0.47 |
|
| 2002 |
Xu H, Teoman Uysal K, David Becherer J, Arner P, Hotamisligil GS. Altered tumor necrosis factor-α (TNF-α) processing in adipocytes and increased expression of transmembrane TNF-α in obesity Diabetes. 51: 1876-1883. PMID 12031976 DOI: 10.2337/Diabetes.51.6.1876 |
0.386 |
|
| 2002 |
Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology. 143: 1502-11. PMID 11897709 DOI: 10.1210/Endo.143.4.8715 |
0.456 |
|
| 2002 |
Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, ... ... Hotamisligil GS, et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. Journal of Cellular Physiology. 190: 251-8. PMID 11807829 DOI: 10.1002/Jcp.10061 |
0.486 |
|
| 2001 |
Fisher RM, Eriksson P, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M, Hamsten A, Arner P. Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals Diabetologia. 44: 1268-1273. PMID 11692175 DOI: 10.1007/S001250100643 |
0.46 |
|
| 2001 |
Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Obberghen EV. SOCS-3 inhibits insulin signaling and is up-regulated in response to TNF-a in the adipose tissue of obese mice Journal of Biological Chemistry. PMID 11604392 DOI: 10.1074/Jbc.M104602200 |
0.5 |
|
| 2001 |
Xu H, Hotamisligil GS. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation Febs Letters. 506: 97-102. PMID 11591379 DOI: 10.1016/S0014-5793(01)02889-7 |
0.332 |
|
| 2001 |
Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men Atherosclerosis. 157: 495-503. PMID 11472752 DOI: 10.1016/S0021-9150(00)00755-3 |
0.454 |
|
| 2001 |
Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis Nature Medicine. 7: 699-705. PMID 11385507 DOI: 10.1038/89076 |
0.415 |
|
| 2001 |
Way JM, Görgün CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 276: 25651-3. PMID 11373275 DOI: 10.1074/Jbc.C100189200 |
0.499 |
|
| 2001 |
Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men International Journal of Obesity. 25: 106-114. PMID 11244465 DOI: 10.1038/Sj.Ijo.0801468 |
0.355 |
|
| 2001 |
Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E. SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice Journal of Biological Chemistry. 276: 47944-47949. |
0.373 |
|
| 2000 |
Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte International Journal of Obesity. 24: S23-S27. PMID 11126235 DOI: 10.1038/sj/ijo/0801497 |
0.453 |
|
| 2000 |
Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men International Journal of Obesity. 24: 1085-1092. PMID 11033975 DOI: 10.1038/Sj.Ijo.0801361 |
0.42 |
|
| 2000 |
Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science (New York, N.Y.). 290: 134-8. PMID 11021798 DOI: 10.1126/Science.290.5489.134 |
0.362 |
|
| 2000 |
Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2 Endocrinology. 141: 3388-3396. PMID 10965911 DOI: 10.1210/Endo.141.9.7637 |
0.511 |
|
| 2000 |
Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity Proceedings of the National Academy of Sciences of the United States of America. 97: 8033-8038. PMID 10884431 DOI: 10.1073/Pnas.97.14.8033 |
0.481 |
|
| 2000 |
Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. Febs Letters. 469: 77-82. PMID 10708760 DOI: 10.1016/S0014-5793(00)01250-3 |
0.396 |
|
| 2000 |
Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C. Upregulation of uncoupling protein 2 mRNA in genetic obesity: Lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-α Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1484: 41-50. PMID 10685029 DOI: 10.1016/S1388-1981(99)00195-X |
0.413 |
|
| 1999 |
Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2(-/-) mice Diabetes. 48: 1987-1994. PMID 10512363 DOI: 10.2337/Diabetes.48.10.1987 |
0.42 |
|
| 1999 |
Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1. The Journal of Biological Chemistry. 274: 26287-95. PMID 10473584 DOI: 10.1074/Jbc.274.37.26287 |
0.335 |
|
| 1999 |
Hotamisligil GS. The role of TNFα and TNF receptors in obesity and insulin resistance Journal of Internal Medicine. 245: 621-625. PMID 10395191 DOI: 10.1046/j.1365-2796.1999.00490.x |
0.334 |
|
| 1999 |
Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ. Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1 Proceedings of the National Academy of Sciences of the United States of America. 96: 6902-6907. PMID 10359811 DOI: 10.1073/Pnas.96.12.6902 |
0.461 |
|
| 1999 |
Sethi JK, Hotamisligil GS. The role of TNF alpha in adipocyte metabolism. Seminars in Cell & Developmental Biology. 10: 19-29. PMID 10355025 DOI: 10.1006/Scdb.1998.0273 |
0.393 |
|
| 1999 |
Hotamisligil GS. Mechanisms of TNF-α-induced insulin resistance Experimental and Clinical Endocrinology and Diabetes. 107: 119-125. PMID 10320052 DOI: 10.1055/S-0029-1212086 |
0.445 |
|
| 1998 |
Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α- mediated insulin resistance in genetic obesity Endocrinology. 139: 4832-4838. PMID 9832419 DOI: 10.1210/Endo.139.12.6337 |
0.492 |
|
| 1997 |
Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes Journal of Clinical Investigation. 100: 2777-2782. PMID 9389742 DOI: 10.1172/Jci119824 |
0.449 |
|
| 1997 |
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF- α function Nature. 389: 610-614. PMID 9335502 DOI: 10.1038/39335 |
0.428 |
|
| 1997 |
Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes. 46: 451-5. PMID 9032102 DOI: 10.2337/Diab.46.3.451 |
0.628 |
|
| 1996 |
Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (New York, N.Y.). 274: 1377-9. PMID 8910278 DOI: 10.1126/Science.274.5291.1377 |
0.74 |
|
| 1996 |
Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. The Journal of Biological Chemistry. 271: 13018-22. PMID 8662983 DOI: 10.1074/Jbc.271.22.13018 |
0.56 |
|
| 1996 |
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (New York, N.Y.). 271: 665-8. PMID 8571133 DOI: 10.1126/Science.271.5249.665 |
0.596 |
|
| 1996 |
Hotamisligil GS, Peraldi P, Spiegelman BM. The molecular link between obesity and diabetes Current Opinion in Endocrinology and Diabetes. 3: 16-23. DOI: 10.1097/00060793-199602000-00004 |
0.402 |
|
| 1995 |
Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of Clinical Investigation. 95: 2409-15. PMID 7738205 DOI: 10.1172/Jci117936 |
0.593 |
|
| 1994 |
Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134: 264-70. PMID 8275942 DOI: 10.1210/endo.134.1.8275942 |
0.563 |
|
| 1994 |
Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 4854-8. PMID 8197147 DOI: 10.1073/Pnas.91.11.4854 |
0.569 |
|
| 1994 |
Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 43: 1271-8. PMID 7926300 DOI: 10.2337/Diab.43.11.1271 |
0.619 |
|
| 1994 |
Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. The Journal of Clinical Investigation. 94: 1543-9. PMID 7523453 DOI: 10.1172/JCI117495 |
0.59 |
|
| 1993 |
Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF alpha. Cell. 73: 625-7. PMID 8500160 DOI: 10.1016/0092-8674(93)90243-J |
0.566 |
|
| 1993 |
Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. The Journal of Biological Chemistry. 268: 6823-6. PMID 8463205 |
0.533 |
|
| 1993 |
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (New York, N.Y.). 259: 87-91. PMID 7678183 DOI: 10.1126/Science.7678183 |
0.617 |
|
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