Kenneth H. Cowan - Publications

Affiliations: 
Cancer and Allied Diseases University of Nebraska Medical Center, Omaha, NE, United States 
Area:
Molecular Biology, Oncology, Cell Biology

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kolb RH, Greer PM, Cao PT, Cowan KH, Yan Y. Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation. Plos One. 18: e0292423. PMID 37769019 DOI: 10.1371/journal.pone.0292423  0.706
2020 Griess B, Klinkebiel D, Kueh A, Desler M, Cowan K, Fitzgerald M, Teoh-Fitzgerald M. Association of SOD3 promoter DNA methylation with its down-regulation in breast carcinomas. Epigenetics. 15: 1325-1335. PMID 32508251 DOI: 10.1080/15592294.2020.1777666  0.319
2020 Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM. Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget. 11: 304. PMID 32076492 DOI: 10.18632/Oncotarget.27450  0.353
2020 Malekzadeh P, Cowan K, Steinberg SM, Camphausen KA, Shriver C, Merino MJ, Good ML, Berman A, Danforth DN. Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer. American Journal of Clinical Oncology. PMID 32000167 DOI: 10.1097/Coc.0000000000000667  0.311
2019 Maxwell J, Shats O, Aldridge J, Lyden E, Krie A, Conklin R, Manning K, Fahed R, Vaziri I, Deveras RAE, Mateen Z, Crow K, Bjorling V, Meschi JT, Makoni S, ... ... Cowan K, et al. The impact of the affordable care act on breast cancer care in the USA: A multi-institutional analysis. The Breast Journal. PMID 31187577 DOI: 10.1111/Tbj.13373  0.305
2019 Yan Y, Haas JP, Kim M, Sgagias MK, Cowan KH. Withdrawal: BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. The Journal of Biological Chemistry. 294: 8309. PMID 31101659 DOI: 10.1074/Jbc.W119.009053  0.359
2018 Razidlo GL, Johnson HJ, Stoeger SM, Cowan KH, Bessho T, Lewis RE. Correction: KSR1 is required for cell cycle reinitiation following DNA damage. The Journal of Biological Chemistry. 293: 19136. PMID 30530853 DOI: 10.1074/Jbc.Aac118.006696  0.762
2017 Downs B, Xiao F, Kim YC, Chen PX, Huang D, Fleissner EA, Cowan K, Wang SM. Single-base LOH can be used as Specific Marker to Classify BRCAx Familial Breast Cancer into More Homogenous Subtypes. The Breast Journal. PMID 28117528 DOI: 10.1111/Tbj.12777  0.324
2015 Downs B, Kim YC, Xiao F, Snyder C, Chen P, Fleissner EA, Becirovic D, Wen H, Sherman S, Cowan KH, Lynch HT, Wang SM. Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer. Breast Cancer Research and Treatment. 151: 219-24. PMID 25833210 DOI: 10.1007/S10549-015-3358-7  0.311
2015 Li Y, Wang X, Vural S, Mishra NK, Cowan KH, Guda C. Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers. Plos One. 10: e0119383. PMID 25803781 DOI: 10.1371/Journal.Pone.0119383  0.355
2015 Yan Y, Hein AL, Greer PM, Wang Z, Kolb RH, Batra SK, Cowan KH. A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation. Oncogene. 34: 2215-26. PMID 24909175 DOI: 10.1038/Onc.2014.167  0.787
2014 Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM. Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget. 5: 10251-70. PMID 25344910 DOI: 10.18632/Oncotarget.2500  0.432
2014 Xiao F, Kim YC, Snyder C, Wen H, Chen PX, Luo J, Becirovic D, Downs B, Cowan KH, Lynch H, Wang SM. Genome instability in blood cells of a BRCA1+ breast cancer family. Bmc Cancer. 14: 342. PMID 24884718 DOI: 10.1186/1471-2407-14-342  0.358
2013 Xiao F, Kim YC, Wen H, Luo J, Chen P, Cowan K, Wang SM. The genome of polymorphonuclear neutrophils maintains normal coding sequences. Plos One. 8: e78685. PMID 24250807 DOI: 10.1371/Journal.Pone.0078685  0.308
2013 Lynch H, Wen H, Kim YC, Snyder C, Kinarsky Y, Chen PX, Xiao F, Goldgar D, Cowan KH, Wang SM. Can unknown predisposition in familial breast cancer be family-specific? The Breast Journal. 19: 520-8. PMID 23800003 DOI: 10.1111/Tbj.12145  0.31
2012 Kolb RH, Greer PM, Cao PT, Cowan KH, Yan Y. ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation. Plos One. 7: e50281. PMID 23166842 DOI: 10.1371/Journal.Pone.0050281  0.763
2012 Yan Y, Greer PM, Cao PT, Kolb RH, Cowan KH. RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation. Breast Cancer Research : Bcr. 14: R60. PMID 22494620 DOI: 10.1186/Bcr3164  0.78
2012 Lynch HT, Wen H, Kim Y, Snyder C, Kinarsky Y, Chen PX, Cowan KH, Goldgar D, Wang SM. Identification of new susceptibility genes in familial breast cancer by exome sequencing. Journal of Clinical Oncology. 30: 1538-1538. DOI: 10.1200/Jco.2012.30.15_Suppl.1538  0.36
2012 Yan Y, Greer PM, Kolb RH, Cowan KH. Abstract 2041: Her2/Neu has an essential role for the gamma-irradiation-induced ERK1/2 signaling activation and G2/M checkpoint response Cancer Research. 72: 2041-2041. DOI: 10.1158/1538-7445.Am2012-2041  0.517
2011 Sherman S, Shats O, Fleissner E, Bascom G, Yiee K, Copur M, Crow K, Rooney J, Mateen Z, Ketcham MA, Feng J, Sherman A, Gleason M, Kinarsky L, Silva-Lopez E, ... ... Cowan K, et al. Multicenter breast cancer collaborative registry. Cancer Informatics. 10: 217-26. PMID 21918596 DOI: 10.4137/Cin.S7845  0.337
2010 Yan Y, Cao PT, Greer PM, Nagengast ES, Kolb RH, Mumby MC, Cowan KH. Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene. 29: 4317-29. PMID 20498628 DOI: 10.1038/Onc.2010.187  0.752
2009 Razidlo GL, Johnson HJ, Stoeger SM, Cowan KH, Bessho T, Lewis RE. KSR1 is required for cell cycle reinitiation following DNA damage. The Journal of Biological Chemistry. 284: 6705-15. PMID 19147494 DOI: 10.1074/Jbc.M806457200  0.799
2009 Stoeger SM, Cowan KH. Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines. Cancer Chemotherapy and Pharmacology. 63: 807-18. PMID 18661133 DOI: 10.1007/S00280-008-0794-7  0.794
2009 Reed E, Cowan K, Gabrilovich D, Warkentin P, Janssen W, Wisecarver J, Turken O, Coskun U, Anderson J, Mailliard M, Maas S, Lemon S, Talmadge J. Autologous dendritic cell vaccine directed at wild type p53 in patients with high-risk breast cancer treated with adjuvant chemotherapy. Cancer Research. 69: 2152. DOI: 10.1158/0008-5472.Sabcs-2152  0.327
2009 Minton S, Gabrilovich D, Lacevic M, Laronga C, Lee M, Kiluk J, Khakpour N, Bui M, Soliman H, Ismail-khan R, Han H, Munster P, Janssen W, Cowan K, Talmadge J, et al. Neoadjuvant Intratumoral Injection of Dendritic Cells in Breast Cancer. Cancer Research. 69: 4128-4128. DOI: 10.1158/0008-5472.Sabcs-09-4128  0.378
2008 Yan Y, Black CP, Cao PT, Haferbier JL, Kolb RH, Spieker RS, Ristow AM, Cowan KH. Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer Research. 68: 5113-21. PMID 18593910 DOI: 10.1158/0008-5472.Can-07-5818  0.794
2008 Talmadge JE, Reed E, Cowan K, Gabrilovich D, Warkentin P, Janssen WE, Wisecarver J, Anderson J, Mailliard M, Maas S, Turken O, Coskun U. Significant Expansion of Myeloid Derived Suppressor Cells in Patients with High- Risk Breast Cancer Treated with Dose Dense Adjuvant Chemotherapy Blood. 112: 4653-4653. DOI: 10.1182/Blood.V112.11.4653.4653  0.306
2007 Yan Y, Black CP, Cowan KH. Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene. 26: 4689-98. PMID 17297454 DOI: 10.1038/Sj.Onc.1210268  0.473
2007 Yaar M, Eller MS, Panova I, Kubera J, Wee LH, Cowan KH, Gilchrest BA. Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Research : Bcr. 9: R13. PMID 17257427 DOI: 10.1186/Bcr1646  0.343
2006 Muraoka-Cook RS, Caskey LS, Sandahl MA, Hunter DM, Husted C, Strunk KE, Sartor CI, Rearick WA, McCall W, Sgagias MK, Cowan KH, Earp HS. Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1. Molecular and Cellular Biology. 26: 6412-24. PMID 16914727 DOI: 10.1128/Mcb.01950-05  0.481
2006 Das AV, Zhao X, James J, Kim M, Cowan KH, Ahmad I. Neural stem cells in the adult ciliary epithelium express GFAP and are regulated by Wnt signaling. Biochemical and Biophysical Research Communications. 339: 708-16. PMID 16332461 DOI: 10.1016/J.Bbrc.2005.11.064  0.321
2005 Dixon KH, Trepel JB, Eng SC, Cowan KH. Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line. Cancer Communications. 3: 357-65. PMID 16296001 DOI: 10.3727/095535491820873687  0.319
2005 Basma H, El-Refaey H, Sgagias MK, Cowan KH, Luo X, Cheng PW. BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53. Journal of Biomedical Science. 12: 999-1011. PMID 16228292 DOI: 10.1007/S11373-005-9025-Y  0.428
2005 Kim M, Yan Y, Kortum RL, Stoeger SM, Sgagias MK, Lee K, Lewis RE, Cowan KH. Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity. Cancer Research. 65: 3986-92. PMID 15899786 DOI: 10.1158/0008-5472.Can-03-2334  0.793
2005 Yan Y, Spieker RS, Kim M, Stoeger SM, Cowan KH. BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene. 24: 3285-96. PMID 15735702 DOI: 10.1038/Sj.Onc.1208492  0.801
2004 Sgagias MK, Wagner KU, Hamik B, Stoeger S, Spieker R, Huber LJ, Chodosh LA, Cowan KH. Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS. Cell Cycle (Georgetown, Tex.). 3: 1451-6. PMID 15492509 DOI: 10.4161/Cc.3.11.1211  0.788
2004 Kim M, Yan Y, Lee K, Sgagias M, Cowan KH. Ectopic expression of von Hippel-Lindau tumor suppressor induces apoptosis in 786-O renal cell carcinoma cells and regresses tumor growth of 786-O cells in nude mouse. Biochemical and Biophysical Research Communications. 320: 945-50. PMID 15240140 DOI: 10.1016/J.Bbrc.2004.06.042  0.361
2004 Kim M, Sgagias M, Deng X, Jung YJ, Rikiyama T, Lee K, Ouellette M, Cowan K. Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. Biochemical and Biophysical Research Communications. 320: 138-44. PMID 15207713 DOI: 10.1016/J.Bbrc.2004.05.135  0.394
2002 Deng X, Kim M, Vandier D, Jung YJ, Rikiyama T, Sgagias MK, Goldsmith M, Cowan KH. Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin. Biochemical and Biophysical Research Communications. 296: 792-8. PMID 12200117 DOI: 10.1016/S0006-291X(02)00948-8  0.363
2002 Yan Y, Haas JP, Kim M, Sgagias MK, Cowan KH. BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. The Journal of Biological Chemistry. 277: 33422-30. PMID 12082091 DOI: 10.1074/Jbc.M201147200  0.528
2002 Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nature Genetics. 30: 285-9. PMID 11836499 DOI: 10.1038/Ng837  0.451
2002 Kim M, Turnquist H, Jackson J, Sgagias M, Yan Y, Gong M, Dean M, Sharp JG, Cowan K. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 22-8. PMID 11801536  0.333
2000 Vandier D, Rixe O, Besnard F, Kim M, Rikiyama T, Goldsmith M, Brenner M, Gouyette A, Cowan KH. Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter. Cancer Gene Therapy. 7: 1120-6. PMID 10975672 DOI: 10.1038/Sj.Cgt.7700211  0.387
2000 Kim M, Katayose Y, Rojanala L, Shah S, Sgagias M, Jang L, Jung YJ, Lee SH, Hwang SG, Cowan KH. Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein. Cell Death and Differentiation. 7: 706-11. PMID 10918444 DOI: 10.1038/Sj.Cdd.4400703  0.49
2000 Sgagias MK, Nieroda C, Yannelli JR, Cowan KH, Danforth DN. Upregulation of DF3, in association with ICAM-1 and MHC class II by IFN-gamma in short-term human mammary carcinoma cell cultures. Cancer Biotherapy & Radiopharmaceuticals. 11: 177-85. PMID 10851535 DOI: 10.1089/Cbr.1996.11.177  0.39
2000 Paul D, Qazilbash MH, Song K, Xu H, Sinha BK, Liu J, Cowan KH. Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12). Cancer Gene Therapy. 7: 308-15. PMID 10770641 DOI: 10.1038/Sj.Cgt.7700105  0.319
2000 MacLachlan TK, Somasundaram K, Sgagias M, Shifman Y, Muschel RJ, Cowan KH, El-Deiry WS. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. The Journal of Biological Chemistry. 275: 2777-85. PMID 10644742 DOI: 10.1074/Jbc.275.4.2777  0.484
2000 Conley B, O'Shaughnessy J, Prindiville S, Lawrence J, Chow C, Jones E, Merino MJ, Kaiser-Kupfer MI, Caruso RC, Podgor M, Goldspiel B, Venzon D, Danforth D, Wu S, Noone M, ... ... Cowan KH, et al. Pilot trial of the safety, tolerability, and retinoid levels of N-(4-hydroxyphenyl) retinamide in combination with tamoxifen in patients at high risk for developing invasive breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 275-83. PMID 10637240 DOI: 10.1200/Jco.2000.18.2.275  0.33
2000 Zujewski J, Pai L, Wakefield L, Giusti R, Dorr FA, Flanders C, Caruso R, Kaiser M, Goodman L, Merino M, Gossard M, Noone MA, Denicoff A, Venzon D, Cowan KH, et al. Tamoxifen and fenretinide in women with metastatic breast cancer. Breast Cancer Research and Treatment. 57: 277-83. PMID 10617304 DOI: 10.1023/A:1006216409688  0.332
2000 Somasundaram K, MacLachlan TK, Burns TF, Sgagias M, Cowan KH, Weber BL, el-Deiry WS. BRCA1 signals ARF-dependent stabilization and coactivation of p53. Oncogene. 18: 6605-14. PMID 10597265 DOI: 10.1038/Sj.Onc.1203284  0.378
1999 Rakkar AN, Katayose Y, Kim M, Craig C, Ohri E, Li Z, Cowan KH, Seth P. A novel adenoviral vector expressing human Fas/CD95/APO-1 enhances p53-mediated apoptosis. Cell Death and Differentiation. 6: 326-33. PMID 10381625 DOI: 10.1038/sj.cdd.4400498  0.317
1999 Gong M, Cowan KH, Gudas J, Moscow JA. Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1). Gene. 233: 21-31. PMID 10375617 DOI: 10.1016/S0378-1119(99)00166-3  0.36
1999 Moscow JA, Huang H, Carter C, Hines K, Zujewski J, Cusack G, Chow C, Venzon D, Sorrentino B, Chiang Y, Goldspiel B, Leitman S, Read EJ, Abati A, Gottesman MM, ... ... Cowan KH, et al. Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells After Breast Cancer Chemotherapy Blood. 94: 52-61. DOI: 10.1182/Blood.V94.1.52.413K35_52_61  0.397
1998 Rakkar ANS, Li Z, Katayose Y, Kim M, Cowan KH, Seth P. Adenoviral Expression of the Cyclin-Dependent Kinase Inhibitor p27Kip1: a Strategy for Breast Cancer Gene Therapy Journal of the National Cancer Institute. 90: 1836-1838. PMID 9839525 DOI: 10.1093/Jnci/90.23.1836  0.395
1998 Craig C, Kim M, Ohri E, Wersto R, Katayose D, Li Z, Choi YH, Mudahar B, Srivastava S, Seth P, Cowan K. Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. Oncogene. 16: 265-72. PMID 9464545 DOI: 10.1038/sj.onc.1201493  0.328
1997 Moscow JA, Connolly T, Myers TG, Cheng CC, Paull K, Cowan KH. Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines. International Journal of Cancer. 72: 184-90. PMID 9212241 DOI: 10.1002/(Sici)1097-0215(19970703)72:1<184::Aid-Ijc26>3.0.Co;2-I  0.423
1997 Morrow C, Cowan KH. Drug resistance markers: are they bad or good? Annals of Oncology : Official Journal of the European Society For Medical Oncology. 8: 314-5. PMID 9209659 DOI: 10.1023/A:1008211227476  0.611
1997 Craig C, Wersto R, Kim M, Ohri E, Li Z, Katayose D, Lee SJ, Trepel J, Cowan K, Seth P. A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells. Oncogene. 14: 2283-9. PMID 9178904 DOI: 10.1038/sj.onc.1201064  0.414
1997 Gong M, Yess J, Connolly T, Ivy SP, Ohnuma T, Cowan KH, Moscow JA. Molecular Mechanism of Antifolate Transport-Deficiency in a Methotrexate-Resistant MOLT-3 Human Leukemia Cell Line Blood. 89: 2494-2499. DOI: 10.1182/Blood.V89.7.2494  0.412
1997 Emmons RVB, Doren S, Zujewski J, Cottler-Fox M, Carter CS, Hines K, O'Shaughnessy JA, Leitman SF, Greenblatt JJ, Cowan K, Dunbar CE. Retroviral gene transduction of adult peripheral blood or marrow-derived CD34+ cells for six hours without growth factors or on autologous stroma does not improve marking efficiency assessed in vivo. Blood. 89: 4040-4046. DOI: 10.1182/Blood.V89.11.4040  0.338
1996 Warren MK, Zujewski J, Rose WL, Szabo JM, O'Shaughnessy JA, Halverson DC, Cowan KH, Gress RE, Schwartz GN. Early suppressive effects of chemotherapy on recovery of bone marrow megakaryocyte precursors: possible relationship to platelet recovery. Stem Cells (Dayton, Ohio). 14: 31-7. PMID 11012200 DOI: 10.1002/Stem.5530140704  0.313
1996 Gudas JM, Nguyen H, Li T, Sadzewicz L, Robey R, Wosikowski K, Cowan KH. Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein. Carcinogenesis. 17: 1417-27. PMID 8706243 DOI: 10.1093/Carcin/17.7.1417  0.475
1996 Tolcher AW, Cowan KH, Solomon D, Ognibene F, Goldspiel B, Chang R, Noone MH, Denicoff AM, Barnes CS, Gossard MR, Fetsch PA, Berg SL, Balis FM, Venzon DJ, O'Shaughnessy JA. Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 14: 1173-84. PMID 8648372 DOI: 10.1200/Jco.1996.14.4.1173  0.318
1996 Fisherman JS, Cowan KH, Noone M, Denicoff A, Berg S, Poplack D, Balis F, Venzon D, McCabe M, Goldspiel B, Chow C, Ognibene FP, O'Shaughnessy J. Phase I/II study of 72-hour infusional paclitaxel and doxorubicin with granulocyte colony-stimulating factor in patients with metastatic breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 14: 774-82. PMID 8622023 DOI: 10.1200/Jco.1996.14.3.774  0.342
1996 Schwartz GN, Hakim F, Zujewski J, Szabo JM, Cepada R, Riseberg D, Warren MK, Mackall CL, Setzer A, Noone M, Cowan KH, O'Shaughnessy J, Gress RE. Early suppressive effects of chemotherapy and cytokine treatment on committed versus primitive haemopoietic progenitors in patient bone marrow. British Journal of Haematology. 92: 537-47. PMID 8616014 DOI: 10.1046/J.1365-2141.1996.00387.X  0.321
1996 Tolcher AW, Cowan KH, Noone MH, Denicoff AM, Kohler DR, Goldspiel BR, Barnes CS, McCabe M, Gossard MR, Zujewski J, O'Shaughnessy JA. Phase I study of paclitaxel in combination with cyclophosphamide and granulocyte colony-stimulating factor in metastatic breast cancer patients. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 14: 95-102. PMID 8558227 DOI: 10.1200/Jco.1996.14.1.95  0.35
1995 Tolcher AW, Giusti RM, O'Shaughnessy JA, Cowan KH. Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy: a report of two cases. Cancer Investigation. 13: 188-92. PMID 7874573 DOI: 10.3109/07357909509011689  0.321
1995 O'Shaughnessy JA, Cowan KH. Current status of paclitaxel in the treatment of breast cancer Breast Cancer Research and Treatment. 33: 27-37. PMID 7749130 DOI: 10.1007/Bf00666068  0.385
1995 Moscow JA, Johnston PG, Cole D, Poplack DG, Cowan KH. Characterization of cross-resistance to methotrexate in a human breast cancer cell line selected for resistance to melphalan. Biochemical Pharmacology. 49: 1069-78. PMID 7748187 DOI: 10.1016/0006-2952(95)98503-2  0.444
1995 Sokolova IA, Cowan KH, Schneider E. Ca2+/Mg(2+)-dependent endonuclease activation is an early event in VP-16-induced apoptosis of human breast cancer MCF7 cells in vitro. Biochimica Et Biophysica Acta. 1266: 135-42. PMID 7742378 DOI: 10.1016/0167-4889(94)00233-5  0.406
1995 Schneider E, Yamazaki H, Sinha BK, Cowan KH. Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation. British Journal of Cancer. 71: 738-43. PMID 7710938 DOI: 10.1038/bjc.1995.144  0.342
1995 Yokomizo A, Kohno K, Wada M, Ono M, Morrow CS, Cowan KH, Kuwano M. Markedly decreased expression of glutathione S-transferase pi gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis. The Journal of Biological Chemistry. 270: 19451-7. PMID 7642628 DOI: 10.1074/Jbc.270.33.19451  0.691
1995 Berg SL, Tolcher A, O'Shaughnessy JA, Denicoff AM, Noone M, Ognibene FP, Cowan KH, Balis FM. Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 13: 2039-42. PMID 7636546 DOI: 10.1200/Jco.1995.13.8.2039  0.314
1995 Katayose D, Wersto R, Cowan K, Seth P. Consequences of p53 gene expression by adenovirus vector on cell cycle arrest and apoptosis in human aortic vascular smooth muscle cells. Biochemical and Biophysical Research Communications. 215: 446-51. PMID 7487976 DOI: 10.1006/Bbrc.1995.2485  0.395
1994 Moscow JA, He R, Gudas JM, Cowan KH. Utilization of multiple polyadenylation signals in the human RHOA protooncogene. Gene. 144: 229-36. PMID 8039707 DOI: 10.1016/0378-1119(94)90382-4  0.433
1994 Morrow CS, Nakagawa M, Goldsmith ME, Madden MJ, Cowan KH. Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells. The Journal of Biological Chemistry. 269: 10739-46. PMID 7908296  0.644
1994 O'Shaughnessy JA, Denicoff AM, Venzon DJ, Danforth D, Pierce LJ, Frame JN, Bastian A, Ghosh B, Goldspiel B, Miller L, Dorr FA, Keegan P, Ben-Bamch N, Mrose H, Noone M, ... Cowan KH, et al. A dose intensity study of FLAC (5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide) chemotherapy and Escherichia coli-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) in advanced breast cancer patients Annals of Oncology. 5: 709-716. PMID 7826903 DOI: 10.1093/Oxfordjournals.Annonc.A058975  0.328
1994 Schneider E, Cowan KH. Multiple drug resistance in cancer therapy Medical Journal of Australia. 160: 371-373. DOI: 10.5694/J.1326-5377.1994.Tb138241.X  0.32
1993 Moscow JA, Swanson CA, Cowan KH. Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan. British Journal of Cancer. 68: 732-7. PMID 8398701 DOI: 10.1038/bjc.1993.419  0.337
1993 Molina R, Oesterreich S, Zhou JL, Tandon AK, Clark GM, Allred DC, Townsend AJ, Moscow JA, Cowan KH, McGuire WL. Glutathione transferase GST pi in breast tumors evaluated by three techniques. Disease Markers. 11: 71-82. PMID 8261735 DOI: 10.1155/1993/906187  0.371
1993 Morrow CS, Cowan K. Drug resistance and cancer Advances in Experimental Medicine and Biology. 330: 287-305. PMID 8103619  0.605
1993 Dunbar CE, Nienhuis AW, Stewart FM, Quesenberry P, O'Shaughnessy J, Cowan K, Cottler-Fox M, Leitman S, Goodman S, Sorrentino BP. Amendment to clinical research projects. Genetic marking with retroviral vectors to study the feasibility of stem cell gene transfer and the biology of hematopoietic reconstitution after autologous transplantation in multiple myeloma, chronic myelogenous leukemia, or metastatic breast cancer. Human Gene Therapy. 4: 205-22. PMID 8098622 DOI: 10.1089/Hum.1993.4.2-205  0.321
1993 Madden MJ, Morrow CS, Nakagawa M, Goldsmith ME, Fairchild CR, Cowan KH. Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdr1 gene in vivo. The Journal of Biological Chemistry. 268: 8290-7. PMID 8096520  0.644
1993 Goldsmith ME, Madden MJ, Morrow CS, Cowan KH. A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene. The Journal of Biological Chemistry. 268: 5856-60. PMID 8095499  0.625
1993 Morrow CS, Cowan KH. Antineoplastic drug resistance and breast cancer. Annals of the New York Academy of Sciences. 698: 289-312. PMID 7904140 DOI: 10.1111/J.1749-6632.1993.Tb17220.X  0.658
1993 Ben-Baruch N, Denicoff AM, Goldspiel BR, O'Shaughnessy JA, Cowan KH. Phase II study of fazarabine (NSC 281272) in patients with metastatic colon cancer. Investigational New Drugs. 11: 71-4. PMID 7688714 DOI: 10.1007/Bf00873915  0.328
1993 Chung KN, Saikawa Y, Paik TH, Dixon KH, Mulligan T, Cowan KH, Elwood PC. Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates. The Journal of Clinical Investigation. 91: 1289-94. PMID 7682567 DOI: 10.1172/JCI116327  0.312
1993 Johnston PG, Kleiner D, Cowan KH. Fazarabine American Journal of Clinical Oncology. 16: 34-37. DOI: 10.1097/00000421-199302000-00009  0.315
1992 Morrow CS, Chiu J, Cowan KH. Posttranscriptional control of glutathione S-transferase pi gene expression in human breast cancer cells. The Journal of Biological Chemistry. 267: 10544-50. PMID 1587835  0.648
1992 Moscow JA, Morrow CS, He R, Mullenbach GT, Cowan KH. Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1). The Journal of Biological Chemistry. 267: 5949-58. PMID 1556108  0.642
1992 Moscow JA, Morrow CS, Cowan KH. Multidrug resistance. Cancer Chemotherapy and Biological Response Modifiers. 13: 91-114. PMID 1356403  0.57
1991 Yu G, Ahmad S, Aquino A, Fairchild CR, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Cowan KH, Glazer RI. Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Communications. 3: 181-9. PMID 1675575 DOI: 10.3727/095535491820873263  0.424
1991 Fairchild CR, Cowan KH. Keynote address: multidrug resistance: a pleiotropic response to cytotoxic drugs. International Journal of Radiation Oncology, Biology, Physics. 20: 361-7. PMID 1671383 DOI: 10.1016/0360-3016(91)90121-J  0.389
1991 Townsend AJ, Morrow CS, Sinha BK, Cowan KH. Selenium-dependent glutathione peroxidase expression is inversely related to estrogen receptor content of human breast cancer cells. Cancer Communications. 3: 265-70. PMID 1653587 DOI: 10.3727/095535491820873119  0.699
1990 Morrow CS, Cowan KH. Glutathione S-transferases and drug resistance. Cancer Cells (Cold Spring Harbor, N.Y. : 1989). 2: 15-22. PMID 2201336 DOI: 10.1007/978-1-4613-1601-5_11  0.626
1990 Morrow CS, Cowan KH. Multidrug resistance associated with altered topoisomerase II activity--topoisomerases II as targets for rational drug design. Journal of the National Cancer Institute. 82: 638-9. PMID 2157026 DOI: 10.1093/Jnci/82.8.638  0.618
1990 Morrow CS, Goldsmith ME, Cowan KH. Regulation of human glutathione S-transferase pi gene transcription: influence of 5'-flanking sequences and trans-activating factors which recognize AP-1-binding sites. Gene. 88: 215-25. PMID 2112105 DOI: 10.1016/0378-1119(90)90034-O  0.668
1989 Whelan RD, Hosking LK, Townsend AJ, Cowan KH, Hill BT. Differential increases in glutathione S-transferase activities in a range of multidrug-resistant human tumor cell lines Cancer Communications. 1: 359-365. PMID 2702041 DOI: 10.3727/095535489820875057  0.388
1989 Morrow CS, Cowan KH, Goldsmith ME. Structure of the human genomic glutathione S-transferase-pi gene. Gene. 75: 3-11. PMID 2542132 DOI: 10.1016/0378-1119(89)90377-6  0.608
1989 Vickers PJ, Dufresne MJ, Cowan KH. Relation between cytochrome P450IA1 expression and estrogen receptor content of human breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 3: 157-64. PMID 2464754 DOI: 10.1210/mend-3-1-157  0.351
1988 Vickers PJ, Dickson RB, Shoemaker R, Cowan KH. A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo Molecular Endocrinology. 2: 886-892. PMID 3185565 DOI: 10.1210/mend-2-10-886  0.303
1988 Morrow CS, Cowan KH. Mechanisms and clinical significance of multidrug resistance. Oncology (Williston Park, N.Y.). 2: 55-63, 66-8. PMID 3079288  0.601
1988 Vickers PP, Dixon RB, Cowan KH. A pleiotropic response associated with resistance of breast cancer cells to antineoplastic drugs and hormonal agents. Trends in Pharmacological Sciences. 9: 443-5. PMID 3078086 DOI: 10.1016/0165-6147(88)90135-6  0.302
1988 Moscow JA, Townsend AJ, Goldsmith ME, Whang-Peng J, Vickers PJ, Poisson R, Legault-Poisson S, Myers CE, Cowan KH. Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 85: 6518-22. PMID 2842775 DOI: 10.1073/Pnas.85.17.6518  0.457
1987 Cowan KH, Batist G, Tulpule A, Sinha BK, Myers CE. Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proceedings of the National Academy of Sciences of the United States of America. 83: 9328-32. PMID 3540935 DOI: 10.1073/Pnas.83.24.9328  0.303
1987 Fairchild CR, Ivy SP, Rushmore T, Lee G, Koo P, Goldsmith ME, Myers CE, Farber E, Cowan KH. Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proceedings of the National Academy of Sciences of the United States of America. 84: 7701-5. PMID 2890168 DOI: 10.1073/Pnas.84.21.7701  0.392
1986 Goldsmith ME, Beckman CA, Cowan KH. 5' Nucleotide sequences influence serum-modulated expression of a human dihydrofolate reductase minigene. Molecular and Cellular Biology. 6: 878-86. PMID 3022136 DOI: 10.1128/MCB.6.3.878  0.303
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