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Christine M. Freeman, Ph.D. - Publications

Affiliations: 
2006 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Immunology, Pathology, Cell Biology
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ryu MH, Yun JH, Morrow JD, Saferali A, Castaldi P, Chase R, Stav M, Xu Z, Barjaktarevic I, Han M, Labaki W, Huang YJ, Christenson S, O'Neal W, Bowler R, ... ... Freeman CM, et al. Blood Gene Expression and Immune Cell Subtypes Associated with COPD Exacerbations. American Journal of Respiratory and Critical Care Medicine. PMID 37286295 DOI: 10.1164/rccm.202301-0085OC  0.355
2022 Madapoosi SS, Cruickshank-Quinn C, Opron K, Erb-Downward JR, Begley LA, Li G, Barjaktarevic I, Barr RG, Comellas AP, Couper D, Cooper CB, Freeman C, Han M, Kaner RJ, Labaki W, et al. Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage COPD. American Journal of Respiratory and Critical Care Medicine. PMID 35536732 DOI: 10.1164/rccm.202110-2241OC  0.3
2021 Pallazola AM, Rao JX, Mengistu DT, Morcos MS, Toma MS, Stolberg VR, Tretyakova A, McCloskey L, Curtis JL, Freeman CM. Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in Chronic Obstructive Pulmonary Disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 34704847 DOI: 10.1152/ajplung.00322.2020  0.419
2021 Opron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, Graham Barr R, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, et al. Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort. Npj Biofilms and Microbiomes. 7: 14. PMID 33547327 DOI: 10.1038/s41522-021-00185-9  0.437
2020 Zhang WZ, Oromendia C, Kikkers SA, Butler JJ, O'Beirne S, Kim K, O'Neal WK, Freeman CM, Christenson SA, Peters SP, Wells JM, Doerschuk C, Putcha N, Barjaktarevic I, Woodruff PG, et al. Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS. Scientific Reports. 10: 10562. PMID 32601308 DOI: 10.1038/S41598-020-67047-W  0.313
2020 Freeman CM, Curtis JL. It's Complicated: Lung Dendritic Cells in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. PMID 32286855 DOI: 10.1164/Rccm.202004-0899Ed  0.462
2019 Norman KC, Freeman CM, Bidthanapally NS, Han MK, Martinez FJ, Curtis JL, Arnold KB. Inference of Cellular Immune Environments in Sputum and Peripheral Blood Associated with Acute Exacerbations of COPD. Cellular and Molecular Bioengineering. 12: 165-177. PMID 31719907 DOI: 10.1007/S12195-019-00567-2  0.353
2019 Wells JM, Xing D, Viera L, Burkes RM, Wu Y, Bhatt SP, Dransfield MT, Couper DJ, O'Neal W, Hoffman EA, Gaggar A, Barjaktarevic I, Curtis JL, Labaki WW, Han MLK, ... Freeman CM, et al. The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS. Respiratory Research. 20: 254. PMID 31718676 DOI: 10.1186/S12931-019-1230-8  0.353
2019 Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, et al. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report. American Journal of Respiratory Cell and Molecular Biology. 61: 150-161. PMID 31368812 DOI: 10.1165/Rcmb.2019-0191St  0.378
2019 Verhamme FM, Freeman CM, Brusselle GG, Bracke KR, Curtis JL. Growth Differentiation Factor (GDF)-15 in Pulmonary and Critical Care Medicine. American Journal of Respiratory Cell and Molecular Biology. PMID 30633545 DOI: 10.1165/Rcmb.2018-0379Tr  0.375
2018 Finch DK, Stolberg VR, Ferguson J, Alikaj H, Kady MR, Richmond BW, Polosukhin VV, Blackwell TS, McCloskey L, Curtis JL, Freeman CM. Lung Dendritic Cells Drive NK Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα. American Journal of Respiratory and Critical Care Medicine. PMID 29676596 DOI: 10.1164/Rccm.201712-2513Oc  0.522
2018 Mancuso P, Curtis JL, Freeman CM, Peters-Golden M, Weinberg JB, Myers MG. Ablation of the Leptin receptor in Myeloid Cells Impairs Pulmonary Clearance of Streptococcus Pneumoniae and Alveolar Macrophage Bactericidal Function. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29565180 DOI: 10.1152/Ajplung.00447.2017  0.374
2018 Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley P, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, et al. At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. PMID 29406779 DOI: 10.1164/Rccm.201710-2028Pp  0.434
2018 Kady M, Christenson S, Stolberg V, Bates M, Labaki W, Alexis N, Barjaktarevic I, Barr G, Bleecker E, Boucher R, Bowler R, Cooper C, Couper D, Doerschuk C, Han M, ... ... Freeman C, et al. Lung dendritic cells correlate to small airway abnormality & lung CD4+ T cells: SPIROMICS bronchoscopy study European Respiratory Journal. 52. DOI: 10.1183/13993003.Congress-2018.Oa4925  0.517
2017 Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, ... ... Freeman CM, et al. Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. The Journal of Allergy and Clinical Immunology. PMID 28916185 DOI: 10.1016/J.Jaci.2017.07.039  0.409
2017 Martinez CH, Freeman CM, Nelson JD, Murray S, Wang X, Budoff MJ, Dransfield MT, Hokanson JE, Kazerooni EA, Kinney GL, Regan EA, Wells JM, Martinez FJ, Han MK, Curtis JL, et al. GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respiratory Research. 18: 42. PMID 28245821 DOI: 10.1186/S12931-017-0521-1  0.319
2017 Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Falkowski NR, Huffnagle GB, Curtis JL. Bacterial Topography of the Healthy Human Lower Respiratory Tract. Mbio. 8. PMID 28196961 DOI: 10.1128/Mbio.02287-16  0.386
2016 Freeman CM, Curtis JL. Lung Dendritic Cells: Shaping Immune Responses Throughout COPD Progression. American Journal of Respiratory Cell and Molecular Biology. PMID 27767327 DOI: 10.1165/Rcmb.2016-0272Tr  0.517
2015 Curtis JL, Freeman CM, Huffnagle GB. "B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 192: 648-51. PMID 26371807 DOI: 10.1164/Rccm.201506-1230Ed  0.457
2015 Freeman CM, Martinez CH, Todt JC, Martinez FJ, Han MK, Thompson DL, McCloskey L, Curtis JL. Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood. Respiratory Research. 16: 94. PMID 26243260 DOI: 10.1186/S12931-015-0251-1  0.464
2015 Stolberg VR, McCubbrey AL, Freeman CM, Brown JP, Crudgington SW, Taitano SH, Saxton BL, Mancuso P, Curtis JL. Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function. Journal of Immunology (Baltimore, Md. : 1950). 195: 174-84. PMID 25987742 DOI: 10.4049/Jimmunol.1402217  0.453
2015 Bourdonnay E, Zas?ona Z, Penke LR, Speth JM, Schneider DJ, Przybranowski S, Swanson JA, Mancuso P, Freeman CM, Curtis JL, Peters-Golden M. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. The Journal of Experimental Medicine. 212: 729-42. PMID 25847945 DOI: 10.1084/Jem.20141675  0.378
2015 Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB, Curtis JL. Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography. Annals of the American Thoracic Society. 12: 821-30. PMID 25803243 DOI: 10.1513/Annalsats.201501-029Oc  0.385
2015 Bassis CM, Erb-Downward JR, Dickson RP, Freeman CM, Schmidt TM, Young VB, Beck JM, Curtis JL, Huffnagle GB. Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals. Mbio. 6: e00037. PMID 25736890 DOI: 10.1128/Mbio.00037-15  0.36
2015 Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R, Rennard SI, et al. Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). Journal of Translational Medicine. 13: 19. PMID 25622723 DOI: 10.1186/S12967-014-0374-Z  0.345
2015 Curtis JL, Freeman CM. Why do we need a nonhuman primate model of smoking-induced COPD? The American Journal of Pathology. 185: 610-3. PMID 25576784 DOI: 10.1016/J.Ajpath.2014.12.002  0.318
2014 Freeman CM, Stolberg VR, Crudgington S, Martinez FJ, Han MK, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease. Plos One. 9: e103840. PMID 25078269 DOI: 10.1371/Journal.Pone.0103840  0.67
2014 Freeman CM, McCubbrey AL, Crudgington S, Nelson J, Martinez FJ, Han MK, Washko GR, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent. Plos One. 9: e96421. PMID 24805101 DOI: 10.1371/Journal.Pone.0096421  0.7
2014 Stolberg VR, Martin B, Mancuso P, Olszewski MA, Freeman CM, Curtis JL, Chensue SW. Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure. The American Journal of Pathology. 184: 454-63. PMID 24333113 DOI: 10.1016/J.Ajpath.2013.10.017  0.678
2013 Todt JC, Freeman CM, Brown JP, Sonstein J, Ames TM, McCubbrey AL, Martinez FJ, Chensue SW, Beck JM, Curtis JL. Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. Respiratory Research. 14: 33. PMID 23497334 DOI: 10.1186/1465-9921-14-33  0.604
2013 Freeman CM, Martinez FJ, Han MK, Washko GR, McCubbrey AL, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respiratory Research. 14: 13. PMID 23374856 DOI: 10.1186/1465-9921-14-13  0.695
2012 McCubbrey AL, Sonstein J, Ames TM, Freeman CM, Curtis JL. Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα. Journal of Immunology (Baltimore, Md. : 1950). 189: 112-9. PMID 22615206 DOI: 10.4049/Jimmunol.1200984  0.44
2011 Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB. Analysis of the lung microbiome in the "healthy" smoker and in COPD. Plos One. 6: e16384. PMID 21364979 DOI: 10.1371/Journal.Pone.0016384  0.404
2010 Freeman CM, Han MK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak TJ, Sonstein J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. Journal of Immunology (Baltimore, Md. : 1950). 184: 6504-13. PMID 20427767 DOI: 10.4049/Jimmunol.1000006  0.712
2009 Han MK, Bartholmai B, Liu LX, Murray S, Curtis JL, Sciurba FC, Kazerooni EA, Thompson B, Frederick M, Li D, Schwarz M, Limper A, Freeman C, Landreneau RJ, Wise R, et al. Clinical significance of radiologic characterizations in COPD. Copd. 6: 459-67. PMID 19938970 DOI: 10.3109/15412550903341513  0.306
2009 Freeman CM, Martinez FJ, Han MK, Ames TM, Chensue SW, Todt JC, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 180: 1179-88. PMID 19729666 DOI: 10.1164/Rccm.200904-0552Oc  0.672
2009 Curtis JL, Todt JC, Hu B, Osterholzer JJ, Freeman CM. Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake. Frontiers in Bioscience (Landmark Edition). 14: 2631-46. PMID 19273223 DOI: 10.2741/3401  0.346
2007 Curtis JL, Freeman CM, Hogg JC. The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research. Proceedings of the American Thoracic Society. 4: 512-21. PMID 17878463 DOI: 10.1513/pats.200701-002FM  0.451
2007 Freeman CM, Curtis JL, Chensue SW. CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. The American Journal of Pathology. 171: 767-76. PMID 17640964 DOI: 10.2353/Ajpath.2007.061177  0.705
2007 Chiu BC, Stolberg VR, Freeman CM, Chensue SW. Mononuclear phagocyte-derived interleukin-10 suppresses the innate pulmonary granuloma cytokine response in aged mice. The American Journal of Pathology. 171: 829-37. PMID 17631521 DOI: 10.2353/Ajpath.2007.061122  0.665
2006 Freeman CM, Stolberg VR, Chiu BC, Lukacs NW, Kunkel SL, Chensue SW. CCR4 participation in Th type 1 (mycobacterial) and Th type 2 (schistosomal) anamnestic pulmonary granulomatous responses. Journal of Immunology (Baltimore, Md. : 1950). 177: 4149-58. PMID 16951380 DOI: 10.4049/Jimmunol.177.6.4149  0.693
2006 Hu JS, Freeman CM, Stolberg VR, Chiu BC, Bridger GJ, Fricker SP, Lukacs NW, Chensue SW. AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation. The American Journal of Pathology. 169: 424-32. PMID 16877345 DOI: 10.2353/Ajpath.2006.051234  0.65
2005 Stolberg VR, Chiu BC, Komuniecki E, Freeman CM, Chensue SW. Analysis of inducible costimulatory molecule participation during the induction and elicitation of granulomatous responses to mycobacterial and schistosomal antigens. Cellular Immunology. 237: 45-54. PMID 16300749 DOI: 10.1016/J.Cellimm.2005.09.005  0.629
2005 Freeman CM, Chiu BC, Stolberg VR, Hu J, Zeibecoglou K, Lukacs NW, Lira SA, Kunkel SL, Chensue SW. CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice. Journal of Immunology (Baltimore, Md. : 1950). 174: 1962-70. PMID 15699124 DOI: 10.4049/Jimmunol.174.4.1962  0.687
2004 Chiu BC, Freeman CM, Stolberg VR, Hu JS, Zeibecoglou K, Lu B, Gerard C, Charo IF, Lira SA, Chensue SW. Impaired lung dendritic cell activation in CCR2 knockout mice. The American Journal of Pathology. 165: 1199-209. PMID 15466386 DOI: 10.1016/S0002-9440(10)63380-9  0.667
2004 Chiu BC, Freeman CM, Stolberg VR, Hu JS, Komuniecki E, Chensue SW. The innate pulmonary granuloma: characterization and demonstration of dendritic cell recruitment and function. The American Journal of Pathology. 164: 1021-30. PMID 14982855 DOI: 10.1016/S0002-9440(10)63189-6  0.68
2003 Chiu BC, Freeman CM, Stolberg VR, Komuniecki E, Lincoln PM, Kunkel SL, Chensue SW. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. American Journal of Respiratory Cell and Molecular Biology. 29: 106-16. PMID 12600821 DOI: 10.1165/Rcmb.2002-0241Oc  0.637
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