| Year |
Citation |
Score |
| 2024 |
Du Pont-Thibodeau G, Li SYH, Ducharme-Crevier L, Jutras C, Pantopoulos K, Farrell C, Roumeliotis N, Harrington K, Thibault C, Roy N, Shah A, Lacroix J, Stanworth SJ. Iron Deficiency in Anemic Children Surviving Critical Illness: Post Hoc Analysis of a Single-Center Prospective Cohort in Canada, 2019-2022. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 38358779 DOI: 10.1097/PCC.0000000000003442 |
0.558 |
|
| 2024 |
Michailidou G, Li Y, Zamboulis A, Karlioti G, Meimaroglou D, Pantopoulos K, Bikiaris DN. A Water-Soluble Chitosan Derivative for the Release of Bioactive Deferoxamine. International Journal of Molecular Sciences. 25. PMID 38255991 DOI: 10.3390/ijms25020913 |
0.466 |
|
| 2023 |
Charlebois E, Pantopoulos K. Nutritional Aspects of Iron in Health and Disease. Nutrients. 15. PMID 37299408 DOI: 10.3390/nu15112441 |
0.651 |
|
| 2023 |
Pantopoulos K. Macrophage checkpoint for iron absorption. Blood. 141: 2791-2793. PMID 37289479 DOI: 10.1182/blood.2023020167 |
0.595 |
|
| 2023 |
Bigorra Mir M, Charlebois E, Tsyplenkova S, Fillebeen C, Pantopoulos K. Cardiac mRNA Is Predominantly Expressed in the Right Atrium and Does Not Respond to Iron. International Journal of Molecular Sciences. 24. PMID 36982241 DOI: 10.3390/ijms24065163 |
0.444 |
|
| 2023 |
Charlebois E, Li Y, Wagner V, Pantopoulos K, Olivier M. Genetic Iron Overload Hampers Development of Cutaneous Leishmaniasis in Mice. International Journal of Molecular Sciences. 24. PMID 36675185 DOI: 10.3390/ijms24021669 |
0.628 |
|
| 2022 |
Charlebois E, Fillebeen CC, Presley JF, Cagnone G, Lisi V, Lavallee VP, Joyal JS, Pantopoulos K. Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin bound iron. Blood. PMID 36351237 DOI: 10.1182/blood.2022016987 |
0.699 |
|
| 2022 |
Gu W, Fillebeen C, Pantopoulos K. Human IRP1 Translocates to the Nucleus in a Cell-Specific and Iron-Dependent Manner. International Journal of Molecular Sciences. 23. PMID 36142654 DOI: 10.3390/ijms231810740 |
0.541 |
|
| 2022 |
Charlebois E, Fillebeen C, Katsarou A, Rabinovich A, Wisniewski K, Venkataramani V, Michalke B, Velentza A, Pantopoulos K. A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice. Elife. 11. PMID 36066082 DOI: 10.7554/eLife.81332 |
0.673 |
|
| 2022 |
Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, ... ... Pantopoulos K, et al. The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. Proceedings of the National Academy of Sciences of the United States of America. 119: e2121251119. PMID 35994670 DOI: 10.1073/pnas.2121251119 |
0.49 |
|
| 2022 |
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z. Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway. Cellular and Molecular Life Sciences : Cmls. 79: 394. PMID 35786773 DOI: 10.1007/s00018-022-04423-x |
0.629 |
|
| 2022 |
Allameh A, Hüttmann N, Charlebois E, Katsarou A, Gu W, Gkouvatsos K, Pasini E, Bhat M, Minic Z, Berezovski M, Guido M, Fillebeen C, Pantopoulos K. Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma. Communications Biology. 5: 153. PMID 35194137 DOI: 10.1038/s42003-022-03108-2 |
0.388 |
|
| 2022 |
Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z. Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway. Free Radical Biology & Medicine. PMID 35045311 DOI: 10.1016/j.freeradbiomed.2022.01.012 |
0.554 |
|
| 2021 |
Katsarou A, Gkouvatsos K, Fillebeen C, Pantopoulos K. Tissue-Specific Regulation of Ferroportin in Wild-Type and Hjv-/- Mice Following Dietary Iron Manipulations. Hepatology Communications. 5: 2139-2150. PMID 34558857 DOI: 10.1002/hep4.1780 |
0.636 |
|
| 2021 |
Charlebois E, Pantopoulos K. Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes. Plos One. 16: e0253475. PMID 34161397 DOI: 10.1371/journal.pone.0253475 |
0.646 |
|
| 2021 |
Botta A, Barra NG, Lam NH, Chow S, Pantopoulos K, Schertzer JD, Sweeney G. Iron Reshapes the Gut Microbiome and Host Metabolism. Journal of Lipid and Atherosclerosis. 10: 160-183. PMID 34095010 DOI: 10.12997/jla.2021.10.2.160 |
0.586 |
|
| 2021 |
Pantopoulos K. Iron, FRDA, and intermediary metabolism. Blood. 137: 1994-1995. PMID 33856446 DOI: 10.1182/blood.2021010835 |
0.575 |
|
| 2020 |
Fillebeen C, Lam NH, Chow S, Botta A, Sweeney G, Pantopoulos K. Regulatory Connections between Iron and Glucose Metabolism. International Journal of Molecular Sciences. 21. PMID 33096618 DOI: 10.3390/ijms21207773 |
0.556 |
|
| 2020 |
Katsarou A, Pantopoulos K. Basics and principles of cellular and systemic iron homeostasis. Molecular Aspects of Medicine. 100866. PMID 32564977 DOI: 10.1016/J.Mam.2020.100866 |
0.727 |
|
| 2020 |
Lazaridou M, Christodoulou E, Nerantzaki M, Kostoglou M, Lambropoulou DA, Katsarou A, Pantopoulos K, Bikiaris DN. Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO). Pharmaceutics. 12. PMID 32156022 DOI: 10.3390/Pharmaceutics12030238 |
0.39 |
|
| 2020 |
Sung HK, Song E, Jahng JWS, Pantopoulos K, Sweeney G. Author Correction: Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress. Scientific Reports. 10: 1836. PMID 31996760 DOI: 10.1038/S41598-020-58752-7 |
0.497 |
|
| 2019 |
Galaris D, Barbouti A, Pantopoulos K. Iron homeostasis and oxidative stress: An intimate relationship. Biochimica Et Biophysica Acta. Molecular Cell Research. 1866: 118535. PMID 31446062 DOI: 10.1016/J.Bbamcr.2019.118535 |
0.608 |
|
| 2019 |
Wagner J, Fillebeen C, Haliotis T, Charlebois E, Katsarou A, Mui J, Vali H, Pantopoulos K. Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat diet. Plos One. 14: e0221455. PMID 31442254 DOI: 10.1371/Journal.Pone.0221455 |
0.538 |
|
| 2019 |
Charlebois E, Fillebeen C, Pantopoulos K. Hepatocellular heme oxygenase 1 deficiency does not affect inflammatory hepcidin regulation in mice. Plos One. 14: e0219835. PMID 31295319 DOI: 10.1371/Journal.Pone.0219835 |
0.464 |
|
| 2019 |
Sung HK, Song E, Jahng JWS, Pantopoulos K, Sweeney G. Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress. Scientific Reports. 9: 4668. PMID 30874600 DOI: 10.1038/S41598-019-41111-6 |
0.651 |
|
| 2018 |
Fillebeen C, Charlebois E, Wagner J, Katsarou A, Mui J, Vali H, Garcia-Santos D, Ponka P, Presley J, Pantopoulos K. Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Blood. PMID 30538134 DOI: 10.1182/Blood-2018-05-850404 |
0.671 |
|
| 2018 |
Pantopoulos K. Inherited Disorders of Iron Overload. Frontiers in Nutrition. 5: 103. PMID 30420953 DOI: 10.3389/Fnut.2018.00103 |
0.696 |
|
| 2018 |
Fillebeen C, Wilkinson N, Charlebois E, Katsarou A, Wagner J, Pantopoulos K. Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling. Blood. PMID 30213871 DOI: 10.1182/Blood-2018-03-841197 |
0.635 |
|
| 2017 |
Garcia-Santos D, Hamdi A, Saxova Z, Fillebeen C, Pantopoulos K, Horvathova M, Ponka P. Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in β-thalassemia mouse model. Blood. PMID 29180398 DOI: 10.1182/Blood-2017-07-798728 |
0.564 |
|
| 2017 |
Turato C, Kent P, Sebastiani G, Cannito S, Morello E, Terrin L, Biasiolo A, Simonato D, Parola M, Pantopoulos K, Pontisso P. Serpinb3 is overexpressed in the liver in presence of iron overload. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. PMID 28935635 DOI: 10.1136/Jim-2017-000473 |
0.689 |
|
| 2017 |
Papanikolaou G, Pantopoulos K. Systemic iron homeostasis and erythropoiesis. Iubmb Life. PMID 28387022 DOI: 10.1002/Iub.1629 |
0.736 |
|
| 2016 |
Sebastiani G, Wilkinson N, Pantopoulos K. Pharmacological Targeting of the Hepcidin/Ferroportin Axis. Frontiers in Pharmacology. 7: 160. PMID 27445804 DOI: 10.3389/Fphar.2016.00160 |
0.725 |
|
| 2016 |
Fillebeen C, Gkouvatsos K, Fragoso G, Calvé A, Garcia-Santos D, Buffler M, Becker C, Schümann K, Ponka P, Santos MM, Pantopoulos K. Response to: Dietary and pharmacological factors affecting iron absorption in mice and man. Haematologica. 101: e122. PMID 26928251 DOI: 10.3324/Haematol.2015.139741 |
0.618 |
|
| 2015 |
Fillebeen C, Gkouvatsos K, Fragoso G, Calve' A, Garcia-Santos D, Buffler M, Becker C, Schümann K, Ponka P, Santos MM, Pantopoulos K. Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation. Haematologica. PMID 25975840 DOI: 10.3324/Haematol.2015.126870 |
0.64 |
|
| 2015 |
Pantopoulos K. Iron regulation of hepcidin through Hfe and Hjv: Common or distinct pathways? Hepatology (Baltimore, Md.). 62: 1922-3. PMID 25761647 DOI: 10.1002/hep.27777 |
0.638 |
|
| 2015 |
Pantopoulos K. TfR2 links iron metabolism and erythropoiesis. Blood. 125: 1055-6. PMID 25678434 DOI: 10.1182/Blood-2014-12-617571 |
0.637 |
|
| 2015 |
Kent P, Wilkinson N, Constante M, Fillebeen C, Gkouvatsos K, Wagner J, Buffler M, Becker C, Schümann K, Santos MM, Pantopoulos K. Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin. Journal of Molecular Medicine (Berlin, Germany). 93: 489-98. PMID 25609138 DOI: 10.1007/S00109-015-1253-7 |
0.712 |
|
| 2015 |
Padda RS, Gkouvatsos K, Guido M, Mui J, Vali H, Pantopoulos K. A high-fat diet modulates iron metabolism but does not promote liver fibrosis in hemochromatotic Hjv⁻/⁻ mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G251-61. PMID 25501544 DOI: 10.1152/Ajpgi.00137.2014 |
0.626 |
|
| 2014 |
Fillebeen C, Wilkinson N, Pantopoulos K. Electrophoretic mobility shift assay (EMSA) for the study of RNA-protein interactions: the IRE/IRP example. Journal of Visualized Experiments : Jove. PMID 25548934 DOI: 10.3791/52230 |
0.361 |
|
| 2014 |
Sebastiani G, Pantopoulos K. NTBI unveiled by chelatable fluorescent beads Biochemical Journal. 463: e7-e9. PMID 25301074 DOI: 10.1042/Bj20141083 |
0.532 |
|
| 2014 |
Wilkinson N, Pantopoulos K. The IRP/IRE system in vivo: insights from mouse models. Frontiers in Pharmacology. 5: 176. PMID 25120486 DOI: 10.3389/Fphar.2014.00176 |
0.706 |
|
| 2014 |
Gkouvatsos K, Fillebeen C, Daba A, Wagner J, Sebastiani G, Pantopoulos K. Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels. Plos One. 9: e85530. PMID 24409331 DOI: 10.1371/Journal.Pone.0085530 |
0.807 |
|
| 2013 |
Fillebeen C, Pantopoulos K. Hepatitis C virus infection causes iron deficiency in Huh7.5.1 cells. Plos One. 8: e83307. PMID 24349485 DOI: 10.1371/Journal.Pone.0083307 |
0.583 |
|
| 2013 |
Wilkinson N, Pantopoulos K. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood. 122: 1658-68. PMID 23777768 DOI: 10.1182/Blood-2013-03-492454 |
0.694 |
|
| 2013 |
Chachami G, Lyberopoulou A, Kalousi A, Paraskeva E, Pantopoulos K, Simos G. Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera. Biochemical and Biophysical Research Communications. 435: 540-5. PMID 23665013 DOI: 10.1016/J.Bbrc.2013.04.085 |
0.565 |
|
| 2013 |
Daba A, Gkouvatsos K, Sebastiani G, Pantopoulos K. Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: Compartmentalization is critical for iron sensing Journal of Molecular Medicine. 91: 95-102. PMID 22847740 DOI: 10.1007/S00109-012-0937-5 |
0.811 |
|
| 2012 |
Song W, Zukor H, Lin SH, Liberman A, Tavitian A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM. Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. Journal of Neurochemistry. 123: 325-36. PMID 22881289 DOI: 10.1111/J.1471-4159.2012.07914.X |
0.645 |
|
| 2012 |
Pantopoulos K, Porwal SK, Tartakoff A, Devireddy L. Mechanisms of mammalian iron homeostasis. Biochemistry. 51: 5705-24. PMID 22703180 DOI: 10.1021/Bi300752R |
0.739 |
|
| 2012 |
Daba A, Koromilas AE, Pantopoulos K. Alternative ferritin mRNA translation via internal initiation. Rna (New York, N.Y.). 18: 547-56. PMID 22271759 DOI: 10.1261/Rna.029322.111 |
0.775 |
|
| 2012 |
Gkouvatsos K, Papanikolaou G, Pantopoulos K. Regulation of iron transport and the role of transferrin. Biochimica Et Biophysica Acta. 1820: 188-202. PMID 22085723 DOI: 10.1016/J.Bbagen.2011.10.013 |
0.723 |
|
| 2011 |
Sebastiani G, Gkouvatsos K, Maffettone C, Busatto G, Guido M, Pantopoulos K. Accelerated CCL 4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression Plos One. 6. PMID 21966437 DOI: 10.1371/Journal.Pone.0025138 |
0.461 |
|
| 2011 |
Sebastiani G, Pantopoulos K. Disorders associated with systemic or local iron overload: From pathophysiology to clinical practice Metallomics. 3: 971-986. PMID 21901209 DOI: 10.1039/C1Mt00082A |
0.709 |
|
| 2011 |
Gkouvatsos K, Wagner J, Papanikolaou G, Sebastiani G, Pantopoulos K. Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin Hepatology. 54: 1800-1807. PMID 21748766 DOI: 10.1002/Hep.24547 |
0.655 |
|
| 2011 |
Wang J, Pantopoulos K. Regulation of cellular iron metabolism. The Biochemical Journal. 434: 365-81. PMID 21348856 DOI: 10.1042/Bj20101825 |
0.739 |
|
| 2011 |
Hausmann A, Lee J, Pantopoulos K. Redox control of iron regulatory protein 2 stability. Febs Letters. 585: 687-92. PMID 21281640 DOI: 10.1016/J.Febslet.2011.01.036 |
0.736 |
|
| 2011 |
Gkouvatsos K, Pantopoulos K. 893 IRON-DEPENDENT REGULATION OF HEPATIC HEPCIDIN EXPRESSION IN HJV-/- MICE Journal of Hepatology. 54: S355-S356. DOI: 10.1016/S0168-8278(11)60895-7 |
0.547 |
|
| 2011 |
Fillebeen C, Pantopoulos K. Reply to: Hepatocyte iron accumulation: A new string to ribavirin’s antiviral bow? Journal of Hepatology. 55: 238. DOI: 10.1016/J.Jhep.2011.02.009 |
0.686 |
|
| 2011 |
Fillebeen C, Pantopoulos K. Reply to: Is there any association between HCV multiplication and iron induced liver injury in chronic hepatitis C? Journal of Hepatology. 55: 236-237. DOI: 10.1016/J.Jhep.2011.01.004 |
0.433 |
|
| 2011 |
Fillebeen C, Pantopoulos K. Erratum to: Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells [J Hepatol. 2010 Dec;53(6):995–999] Journal of Hepatology. 55: 240. DOI: 10.1016/J.Jhep.2010.12.015 |
0.521 |
|
| 2010 |
Fillebeen C, Pantopoulos K. Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells. Journal of Hepatology. 53: 995-9. PMID 20813419 DOI: 10.1016/J.Jhep.2010.04.044 |
0.576 |
|
| 2010 |
Maffettone C, Chen G, Drozdov I, Ouzounis C, Pantopoulos K. Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert. Plos One. 5: e10163. PMID 20405006 DOI: 10.1371/Journal.Pone.0010163 |
0.459 |
|
| 2010 |
Schümann K, Herbach N, Kerling C, Seifert M, Fillebeen C, Prysch I, Reich J, Weiss G, Pantopoulos K. Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation. Journal of Trace Elements in Medicine and Biology : Organ of the Society For Minerals and Trace Elements (Gms). 24: 58-66. PMID 20122582 DOI: 10.1016/J.Jtemb.2009.10.002 |
0.651 |
|
| 2009 |
Zukor H, Song W, Liberman A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM. HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues. Journal of Neurochemistry. 109: 776-91. PMID 19250338 DOI: 10.1111/J.1471-4159.2009.06007.X |
0.656 |
|
| 2008 |
Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Molecular Cell. 32: 838-48. PMID 19111663 DOI: 10.1016/J.Molcel.2008.12.004 |
0.466 |
|
| 2008 |
Pantopoulos K. Function of the hemochromatosis protein HFE: Lessons from animal models. World Journal of Gastroenterology. 14: 6893-901. PMID 19058322 DOI: 10.3748/Wjg.14.6893 |
0.73 |
|
| 2008 |
Dycke C, Charbonnier P, Pantopoulos K, Moulis JM. A role for lysosomes in the turnover of human iron regulatory protein 2. The International Journal of Biochemistry & Cell Biology. 40: 2826-32. PMID 18582596 DOI: 10.1016/J.Biocel.2008.05.015 |
0.73 |
|
| 2008 |
Koliaraki V, Marinou M, Samiotaki M, Panayotou G, Pantopoulos K, Mamalaki A. Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris. Biochimie. 90: 726-35. PMID 18295606 DOI: 10.1016/j.biochi.2008.01.012 |
0.5 |
|
| 2008 |
Galaris D, Pantopoulos K. Oxidative stress and iron homeostasis: mechanistic and health aspects. Critical Reviews in Clinical Laboratory Sciences. 45: 1-23. PMID 18293179 DOI: 10.1080/10408360701713104 |
0.696 |
|
| 2008 |
Wang J, Chen G, Filebeen C, Pantopoulos K. Insights on regulation and function of the iron regulatory protein 1 (IRP1). Hemoglobin. 32: 109-15. PMID 18274988 DOI: 10.1080/03630260701680326 |
0.668 |
|
| 2008 |
Wang J, Chen G, Lee J, Pantopoulos K. Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity. Bmc Molecular Biology. 9: 15. PMID 18226225 DOI: 10.1186/1471-2199-9-15 |
0.714 |
|
| 2008 |
Andriopoulos B, Hegedüsch S, Mangin J, Wang J, Pantopoulos K, Mueller S. Sustained oxidative stress (H2O2) increases hepatic iron accumulation via translational stimulation of transferrin receptor 1 synthesis independent of the IRE/IRP network Zeitschrift FüR Gastroenterologie. 46. DOI: 10.1055/s-2008-1037551 |
0.477 |
|
| 2007 |
Dycke C, Bougault C, Gaillard J, Andrieu JP, Pantopoulos K, Moulis JM. Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein. The Biochemical Journal. 408: 429-39. PMID 17760563 DOI: 10.1042/Bj20070983 |
0.568 |
|
| 2007 |
Andriopoulos B, Hegedüsch S, Mangin J, Riedel HD, Hebling U, Wang J, Pantopoulos K, Mueller S. Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network. The Journal of Biological Chemistry. 282: 20301-8. PMID 17517884 DOI: 10.1074/Jbc.M702463200 |
0.706 |
|
| 2007 |
Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K. Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. Journal of Hepatology. 47: 12-22. PMID 17399844 DOI: 10.1016/J.Jhep.2007.01.035 |
0.667 |
|
| 2007 |
Wang J, Fillebeen C, Chen G, Biederbick A, Lill R, Pantopoulos K. Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway. Molecular and Cellular Biology. 27: 2423-30. PMID 17242182 DOI: 10.1128/Mcb.01111-06 |
0.71 |
|
| 2007 |
Chen G, Fillebeen C, Wang J, Pantopoulos K. Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts. Carcinogenesis. 28: 785-91. PMID 17127713 DOI: 10.1093/Carcin/Bgl210 |
0.677 |
|
| 2007 |
Andriopoulos B, Rest D, Hegedusch S, Welker A, Wang J, Pantopoulos K, Mueller S. [738] OXIDATIVE STRESS (H2O2) INCREASES HEPATIC IRON ACCUMULATION VIA STIMULATION OF TRANSFERRIN RECEPTOR 1 SYNTHESIS INDEPENDENT OF THE IRE/IRP NETWORK Journal of Hepatology. 46: S278. DOI: 10.1016/S0168-8278(07)62336-8 |
0.552 |
|
| 2006 |
Nie G, Chen G, Sheftel AD, Pantopoulos K, Ponka P. In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin. Blood. 108: 2428-34. PMID 16757684 DOI: 10.1182/Blood-2006-04-018341 |
0.66 |
|
| 2006 |
Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, Fein E, Andriopoulos B, Pantopoulos K, Gollan J. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression Journal of Biological Chemistry. 281: 22974-22982. PMID 16737972 DOI: 10.1074/Jbc.M602098200 |
0.563 |
|
| 2006 |
Wang J, Fillebeen C, Chen G, Andriopoulos B, Pantopoulos K. Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178. Molecular and Cellular Biology. 26: 1948-54. PMID 16479012 DOI: 10.1128/Mcb.26.5.1948-1954.2006 |
0.607 |
|
| 2006 |
Andriopoulos B, Pantopoulos K. Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes. Journal of Hepatology. 44: 1125-31. PMID 16460831 DOI: 10.1016/J.Jhep.2005.10.025 |
0.682 |
|
| 2006 |
Rost D, Andriopoulos B, Hegedusch S, Mangin J, Welker A, Riedel H, Hebling U, Wang J, Pantopoulos K, Mueller S. 703 Sustained non-toxic oxidative stress (h2o2) increases hepatic transferrin receptor 1 mediated iron uptake in vitro and in vivo independent of the IL-6/Hepcidin and IRE/IRP1 network Journal of Hepatology. 44: S259. DOI: 10.1016/S0168-8278(06)80703-8 |
0.529 |
|
| 2005 |
Wang J, Chen G, Pantopoulos K. Inhibition of transferrin receptor 1 transcription by a cell density response element. The Biochemical Journal. 392: 383-8. PMID 16092918 DOI: 10.1042/Bj20050492 |
0.539 |
|
| 2005 |
Wang J, Pantopoulos K. The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL. Biochimica Et Biophysica Acta. 1743: 79-85. PMID 15777842 DOI: 10.1016/J.Bbamcr.2004.08.011 |
0.65 |
|
| 2005 |
Wang J, Chen G, Pantopoulos K. Nitric oxide inhibits the degradation of IRP2. Molecular and Cellular Biology. 25: 1347-53. PMID 15684386 DOI: 10.1128/Mcb.25.4.1347-1353.2005 |
0.665 |
|
| 2005 |
Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K. Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. The Journal of Biological Chemistry. 280: 9049-57. PMID 15637067 DOI: 10.1074/Jbc.M412687200 |
0.691 |
|
| 2005 |
Fillebeen C, Caltagirone A, Martelli A, Moulis JM, Pantopoulos K. IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities. The Biochemical Journal. 388: 143-50. PMID 15636585 DOI: 10.1042/Bj20041623 |
0.58 |
|
| 2005 |
Papanikolaou G, Pantopoulos K. Iron metabolism and toxicity. Toxicology and Applied Pharmacology. 202: 199-211. PMID 15629195 DOI: 10.1016/J.Taap.2004.06.021 |
0.721 |
|
| 2005 |
Mehlhase J, Sandig G, Pantopoulos K, Grune T. Oxidation-induced ferritin turnover in microglial cells: role of proteasome. Free Radical Biology & Medicine. 38: 276-85. PMID 15607911 DOI: 10.1016/j.freeradbiomed.2004.10.025 |
0.549 |
|
| 2005 |
Nie G, Chen G, Sheftel A, Pantopoulos K, Ponka P. Effects of Mitochondrial Ferritin Expression on Tumor Iron Metabolism and Tumor Growth in Nude Mice Xenografts. Blood. 106: 3582-3582. DOI: 10.1182/Blood.V106.11.3582.3582 |
0.631 |
|
| 2004 |
Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Annals of the New York Academy of Sciences. 1012: 1-13. PMID 15105251 DOI: 10.1196/Annals.1306.001 |
0.763 |
|
| 2004 |
Kiemer AK, Förnges AC, Pantopoulos K, Bilzer M, Andriopoulos B, Gerwig T, Kenngott S, Gerbes AL, Vollmar AM. ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G518-26. PMID 15087280 DOI: 10.1152/Ajpgi.00514.2003 |
0.52 |
|
| 2004 |
Schümann K, Brennan K, Weiss M, Pantopoulos K, Hentze MW. Rat duodenal IRP1 activity and iron absorption in iron deficiency and after HO perfusion. European Journal of Clinical Investigation. 34: 275-82. PMID 15086359 DOI: 10.1111/J.1365-2362.2004.01335.X |
0.792 |
|
| 2004 |
Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K. Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Molecular and Cellular Biology. 24: 954-65. PMID 14729944 DOI: 10.1128/Mcb.24.3.954-965.2004 |
0.748 |
|
| 2003 |
Fillebeen C, Chahine D, Caltagirone A, Segal P, Pantopoulos K. A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation. Molecular and Cellular Biology. 23: 6973-81. PMID 12972614 DOI: 10.1128/Mcb.23.19.6973-6981.2003 |
0.678 |
|
| 2003 |
Mütze S, Hebling U, Stremmel W, Wang J, Arnhold J, Pantopoulos K, Mueller S. Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1. The Journal of Biological Chemistry. 278: 40542-9. PMID 12888561 DOI: 10.1074/Jbc.M307159200 |
0.638 |
|
| 2003 |
Wang J, Chen G, Pantopoulos K. The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin. The Biochemical Journal. 370: 891-9. PMID 12464008 DOI: 10.1042/Bj20021607 |
0.512 |
|
| 2003 |
HEGEDUSCH S, MANGIN J, ROST D, WELKER A, PANTOPOULOS K, STREMMEL W, MUELLER S. 166 Oxidative stress mediates hepatic iron uptake and Hepatology. 38: 235-235. DOI: 10.1016/S0270-9139(03)80209-4 |
0.612 |
|
| 2002 |
Wang J, Buss JL, Chen G, Ponka P, Pantopoulos K. The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. Febs Letters. 529: 309-12. PMID 12372619 DOI: 10.1016/S0014-5793(02)03389-6 |
0.73 |
|
| 2002 |
Wang J, Pantopoulos K. Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant. Molecular and Cellular Biology. 22: 4638-51. PMID 12052872 DOI: 10.1128/Mcb.22.13.4638-4651.2002 |
0.699 |
|
| 2002 |
Fillebeen C, Pantopoulos K. Redox control of iron regulatory proteins. Redox Report : Communications in Free Radical Research. 7: 15-22. PMID 11981450 DOI: 10.1179/135100002125000136 |
0.745 |
|
| 2002 |
Mueller S, Pantopoulos K. Activation of iron regulatory protein-1 by oxidative stress. Methods in Enzymology. 348: 324-37. PMID 11885287 DOI: 10.1016/S0076-6879(02)48651-X |
0.612 |
|
| 2001 |
Mueller S, Pantopoulos K, Hübner CA, Stremmel W, Hentze MW. IRP1 activation by extracellular oxidative stress in the perfused rat liver. The Journal of Biological Chemistry. 276: 23192-6. PMID 11297549 DOI: 10.1074/Jbc.M100654200 |
0.66 |
|
| 2001 |
Caltagirone A, Weiss G, Pantopoulos K. Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts. The Journal of Biological Chemistry. 276: 19738-45. PMID 11264285 DOI: 10.1074/Jbc.M100245200 |
0.694 |
|
| 1999 |
Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM. Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding. The Journal of Biological Chemistry. 274: 21625-30. PMID 10419470 DOI: 10.1074/Jbc.274.31.21625 |
0.743 |
|
| 1999 |
Gehring NH, Hentze MW, Pantopoulos K. Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. The Journal of Biological Chemistry. 274: 6219-25. PMID 10037708 DOI: 10.1074/Jbc.274.10.6219 |
0.78 |
|
| 1998 |
Pantopoulos K, Hentze MW. Activation of iron regulatory protein-1 by oxidative stress in vitro. Proceedings of the National Academy of Sciences of the United States of America. 95: 10559-63. PMID 9724742 DOI: 10.1073/Pnas.95.18.10559 |
0.74 |
|
| 1998 |
Andersen Ø, Pantopoulos K, Kao HT, Muckenthaler M, Youson JH, Pieribone V. Regulation of iron metabolism in the sanguivore lamprey Lampetra fluviatilis - Molecular cloning of two ferritin subunits and two iron- regulatory proteins (IRP) reveals evolutionary conservation of the iron- regulatory element (IRE)/IRP regulatory system European Journal of Biochemistry. 254: 223-229. PMID 9660174 DOI: 10.1046/j.1432-1327.1998.2540223.x |
0.519 |
|
| 1997 |
Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW. Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress. The Journal of Biological Chemistry. 272: 9802-8. PMID 9092514 DOI: 10.1074/Jbc.272.15.9802 |
0.702 |
|
| 1996 |
Pantopoulos K, Weiss G, Hentze MW. Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways. Molecular and Cellular Biology. 16: 3781-8. PMID 8668195 DOI: 10.1128/Mcb.16.7.3781 |
0.805 |
|
| 1996 |
Gray NK, Pantopoulos K, Dandekar T, Ackrell BA, Hentze MW. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proceedings of the National Academy of Sciences of the United States of America. 93: 4925-30. PMID 8643505 DOI: 10.1073/Pnas.93.10.4925 |
0.799 |
|
| 1995 |
Pantopoulos K, Hentze MW. Rapid responses to oxidative stress mediated by iron regulatory protein. The Embo Journal. 14: 2917-24. PMID 7796817 DOI: 10.1002/J.1460-2075.1995.Tb07291.X |
0.788 |
|
| 1995 |
Pantopoulos K, Gray NK, Hentze MW. Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB. Rna (New York, N.Y.). 1: 155-63. PMID 7585245 |
0.761 |
|
| 1995 |
Pantopoulos K, Hentze MW. Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 92: 1267-71. PMID 7533289 DOI: 10.1073/Pnas.92.5.1267 |
0.796 |
|
| 1994 |
Pantopoulos K, Weiss G, Hentze MW. Nitric oxide and the post-transcriptional control of cellular iron traffic. Trends in Cell Biology. 4: 82-6. PMID 14731597 DOI: 10.1016/0962-8924(94)90179-1 |
0.795 |
|
| 1994 |
Pantopoulos K, Johansson HE, Hentze MW. The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies. Progress in Nucleic Acid Research and Molecular Biology. 48: 181-238. PMID 7938549 DOI: 10.1016/S0079-6603(08)60856-9 |
0.548 |
|
| 1994 |
Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Grünewald K, Wachter H, Hentze MW. Stimulation of IRE-BP activity of IRF by tetrahydrobiopterin and cytokine dependent induction of nitric oxide synthase. Advances in Experimental Medicine and Biology. 356: 133-9. PMID 7534029 |
0.436 |
|
| 1993 |
Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Wachter H, Hentze MW. Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. The Embo Journal. 12: 3651-7. PMID 7504627 DOI: 10.1002/J.1460-2075.1993.Tb06039.X |
0.789 |
|
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