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Geoff P. Horsman, Ph.D. - Publications

Affiliations: 
2011- Chemistry & Biochemistry Wilfrid Laurier University (Canada) 
Area:
Enzymology, Natural products biosynthesis, biocatalysis
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ramos-Figueroa JS, Palmer DRJ, Horsman GP. Phosphoenolpyruvate mutase-catalyzed C-P bond formation: mechanistic ambiguities and opportunities. Chembiochem : a European Journal of Chemical Biology. PMID 35943842 DOI: 10.1002/cbic.202200285  0.333
2022 Li S, Horsman GP. An inventory of early branch points in microbial phosphonate biosynthesis. Microbial Genomics. 8. PMID 35188456 DOI: 10.1099/mgen.0.000781  0.348
2020 Yan Y, Yang J, Wang L, Xu D, Yu Z, Guo X, Horsman GP, Lin S, Tao M, Huang SX. Biosynthetic access to the rare antiarose sugar an unusual reductase-epimerase. Chemical Science. 11: 3959-3964. PMID 34122866 DOI: 10.1039/c9sc05766h  0.365
2020 Wang D, Qi J, Han W, Gao JM, Horsman GP. Kanamycin-induced production of 2',3'-cyclic AMP in Escherichia coli. Biochemical and Biophysical Research Communications. PMID 32430174 DOI: 10.1016/J.Bbrc.2020.04.144  0.336
2020 Yan Y, Yang J, Wang L, Xu D, Yu Z, Guo X, Horsman GP, Lin S, Tao M, Huang S. Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase Chemical Science. 11: 3959-3964. DOI: 10.1039/C9Sc05766H  0.463
2019 Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP. The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis. Nature Communications. 10: 3698. PMID 31420548 DOI: 10.1038/S41467-019-11627-6  0.491
2019 Hao T, Xie Z, Wang M, Liu L, Zhang Y, Wang W, Zhang Z, Zhao X, Li P, Guo Z, Gao S, Lou C, Zhang G, Merritt J, Horsman GP, et al. An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters. Nature Communications. 10: 3665. PMID 31413323 DOI: 10.1038/S41467-019-11673-0  0.303
2017 Bartlett C, Bansal S, Burnett A, Suits MD, Schaefer J, Cegelski L, Horsman GP, Weadge JT. Whole-Cell Detection of C-P Bonds in Bacteria. Biochemistry. PMID 29068202 DOI: 10.1021/Acs.Biochem.7B00814  0.346
2016 Liu L, Hao T, Xie Z, Horsman GP, Chen Y. Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans. Scientific Reports. 6: 37479. PMID 27869143 DOI: 10.1038/Srep37479  0.331
2016 Horsman GP, Zechel DL. Phosphonate Biochemistry. Chemical Reviews. PMID 27787975 DOI: 10.1021/acs.chemrev.6b00536  0.353
2016 Yan Y, Ma YT, Yang J, Horsman GP, Luo D, Ji X, Huang SX. Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces. Organic Letters. PMID 26926531 DOI: 10.1021/Acs.Orglett.6B00074  0.404
2013 Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B. Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry. 52: 5217-24. PMID 23844627 DOI: 10.1021/Bi400572A  0.552
2013 Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Molecular Biosystems. 9: 478-91. PMID 23360970 DOI: 10.1039/C3Mb25523A  0.692
2012 Ruzzini AC, Horsman GP, Eltis LD. The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage. Biochemistry. 51: 5831-40. PMID 22747426 DOI: 10.1021/Bi300663R  0.657
2012 Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Organic Letters. 14: 2300-3. PMID 22519717 DOI: 10.1021/Ol300720S  0.626
2012 Ruzzini AC, Ghosh S, Horsman GP, Foster LJ, Bolin JT, Eltis LD. Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad. Journal of the American Chemical Society. 134: 4615-24. PMID 22339283 DOI: 10.1021/Ja208544G  0.671
2011 Chen Y, Yin M, Horsman GP, Shen B. Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. Journal of Natural Products. 74: 420-4. PMID 21250756 DOI: 10.1021/Np100825Y  0.571
2010 Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B. Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. Journal of the American Chemical Society. 132: 12534-6. PMID 20718468 DOI: 10.1021/Ja1050814  0.539
2010 Lin S, Horsman GP, Shen B. Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster. Organic Letters. 12: 3816-9. PMID 20704329 DOI: 10.1021/Ol101473T  0.502
2010 Chen Y, Yin M, Horsman GP, Huang S, Shen B. Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. 63: 482-5. PMID 20551990 DOI: 10.1038/Ja.2010.55  0.563
2010 Horsman GP, Chen Y, Thorson JS, Shen B. Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes. Proceedings of the National Academy of Sciences of the United States of America. 107: 11331-5. PMID 20534556 DOI: 10.1073/Pnas.1003442107  0.57
2010 Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD. Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. The Journal of Biological Chemistry. 285: 434-43. PMID 19875455 DOI: 10.1074/Jbc.M109.058081  0.626
2009 Lin S, Horsman GP, Chen Y, Li W, Shen B. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. Journal of the American Chemical Society. 131: 16410-7. PMID 19856960 DOI: 10.1021/Ja901242S  0.545
2009 Van Lanen SG, Lin S, Horsman GP, Shen B. Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027. Fems Microbiology Letters. 300: 237-41. PMID 19817865 DOI: 10.1111/J.1574-6968.2009.01802.X  0.632
2009 Horsman GP, Van Lanen SG, Shen B. Iterative type I polyketide synthases for enediyne core biosynthesis. Methods in Enzymology. 459: 97-112. PMID 19362637 DOI: 10.1016/S0076-6879(09)04605-9  0.49
2007 Bhowmik S, Horsman GP, Bolin JT, Eltis LD. The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization. The Journal of Biological Chemistry. 282: 36377-85. PMID 17932031 DOI: 10.1074/Jbc.M707035200  0.646
2007 Horsman GP, Bhowmik S, Seah SY, Kumar P, Bolin JT, Eltis LD. The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad. The Journal of Biological Chemistry. 282: 19894-904. PMID 17442675 DOI: 10.1074/Jbc.M702237200  0.66
2007 Seah SY, Ke J, Denis G, Horsman GP, Fortin PD, Whiting CJ, Eltis LD. Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites. Journal of Bacteriology. 189: 4038-45. PMID 17416660 DOI: 10.1128/Jb.01950-06  0.656
2006 Horsman GP, Ke J, Dai S, Seah SY, Bolin JT, Eltis LD. Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway. Biochemistry. 45: 11071-86. PMID 16964968 DOI: 10.1021/Bi0611098  0.645
2006 Fortin PD, Horsman GP, Yang HM, Eltis LD. A glutathione S-transferase catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls. Journal of Bacteriology. 188: 4424-30. PMID 16740949 DOI: 10.1128/Jb.01849-05  0.634
2005 Horsman GP, Jirasek A, Vaillancourt FH, Barbosa CJ, Jarzecki AA, Xu C, Mekmouche Y, Spiro TG, Lipscomb JD, Blades MW, Turner RF, Eltis LD. Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase. Journal of the American Chemical Society. 127: 16882-91. PMID 16316234 DOI: 10.1021/Ja053800O  0.695
2005 Park S, Morley KL, Horsman GP, Holmquist M, Hult K, Kazlauskas RJ. Focusing mutations into the P. fluorescens esterase binding site increases enantioselectivity more effectively than distant mutations. Chemistry & Biology. 12: 45-54. PMID 15664514 DOI: 10.1016/J.Chembiol.2004.10.012  0.606
2003 Horsman GP, Liu AM, Henke E, Bornscheuer UT, Kazlauskas RJ. Mutations in distant residues moderately increase the enantioselectivity of Pseudomonas fluorescens esterase towards methyl 3bromo-2-methylpropanoate and ethyl 3phenylbutyrate. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 1933-9. PMID 12740839 DOI: 10.1002/Chem.200204551  0.561
2001 Liu AMF, Somers NA, Kazlauskas RJ, Brush TS, Zocher F, Enzelberger MM, Bornscheuer UT, Horsman GP, Mezzetti A, Schmidt-Dannert C, Schmid RD. Mapping the substrate selectivity of new hydrolases using colorimetric screening: Lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas fluorescens and Streptomyces diastatochromogenes Tetrahedron Asymmetry. 12: 545-556. DOI: 10.1016/S0957-4166(01)00072-6  0.588
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