| Year |
Citation |
Score |
| 2014 |
Chung HS, Yang EG, Hwang D, Lee JE, Guan Z, Raetz CR. Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. Biochemical and Biophysical Research Communications. 452: 789-94. PMID 25204504 DOI: 10.1016/J.Bbrc.2014.08.153 |
0.488 |
|
| 2014 |
Qian J, Garrett TA, Raetz CR. In vitro assembly of the outer core of the lipopolysaccharide from Escherichia coli K-12 and Salmonella typhimurium. Biochemistry. 53: 1250-62. PMID 24479701 DOI: 10.1021/Bi4015665 |
0.491 |
|
| 2014 |
Masoudi A, Raetz CR, Zhou P, Pemble CW. Chasing acyl carrier protein through a catalytic cycle of lipid A production. Nature. 505: 422-6. PMID 24196711 DOI: 10.1038/Nature12679 |
0.412 |
|
| 2013 |
Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, et al. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. The Journal of Biological Chemistry. 288: 35812-23. PMID 24189069 DOI: 10.1074/Jbc.M113.519637 |
0.524 |
|
| 2013 |
Sohlenkamp C, Raetz CR, Ingram BO. The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation. Biochimica Et Biophysica Acta. 1831: 1250-9. PMID 24046865 DOI: 10.1016/j.bbalip.2013.04.002 |
0.408 |
|
| 2013 |
Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S. Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification. Molecular Microbiology. 89: 52-64. PMID 23659637 DOI: 10.1111/Mmi.12257 |
0.7 |
|
| 2013 |
Emptage RP, Pemble CW, York JD, Raetz CR, Zhou P. Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis. Biochemistry. 52: 2280-90. PMID 23464738 DOI: 10.1021/Bi400097Z |
0.414 |
|
| 2013 |
Gattis SG, Chung HS, Trent MS, Raetz CR. The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. The Journal of Biological Chemistry. 288: 9216-25. PMID 23413030 DOI: 10.1074/Jbc.M113.453324 |
0.831 |
|
| 2013 |
Sun W, Six DA, Reynolds CM, Chung HS, Raetz CR, Curtiss R. Pathogenicity of Yersinia pestis synthesis of 1-dephosphorylated lipid A. Infection and Immunity. 81: 1172-85. PMID 23357387 DOI: 10.1128/Iai.01403-12 |
0.753 |
|
| 2013 |
Zeng D, Zhao J, Chung HS, Guan Z, Raetz CR, Zhou P. Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. The Journal of Biological Chemistry. 288: 5475-86. PMID 23316051 DOI: 10.1074/Jbc.M112.447607 |
0.48 |
|
| 2012 |
Sohlenkamp C, Raetz CR, Ingram BO. The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation. Biochimica Et Biophysica Acta. 1831: 1250-9. PMID 23583844 DOI: 10.1016/J.Bbalip.2013.04.002 |
0.504 |
|
| 2012 |
Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. LpxI structures reveal how a lipid A precursor is synthesized. Nature Structural & Molecular Biology. 19: 1132-8. PMID 23042606 DOI: 10.1038/Nsmb.2393 |
0.748 |
|
| 2012 |
Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 151: 138-52. PMID 23021221 DOI: 10.1016/J.Cell.2012.06.054 |
0.533 |
|
| 2012 |
Tan BK, Bogdanov M, Zhao J, Dowhan W, Raetz CR, Guan Z. Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. Proceedings of the National Academy of Sciences of the United States of America. 109: 16504-9. PMID 22988102 DOI: 10.1073/Pnas.1212797109 |
0.329 |
|
| 2012 |
Llewellyn AC, Zhao J, Song F, Parvathareddy J, Xu Q, Napier BA, Laroui H, Merlin D, Bina JE, Cotter PA, Miller MA, Raetz CR, Weiss DS. NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Molecular Microbiology. 86: 611-27. PMID 22966934 DOI: 10.1111/Mmi.12004 |
0.515 |
|
| 2012 |
Guan Z, Johnston NC, Raetz CR, Johnson EA, Goldfine H. Lipid diversity among botulinum neurotoxin-producing clostridia. Microbiology (Reading, England). 158: 2577-84. PMID 22837302 DOI: 10.1099/Mic.0.060707-0 |
0.379 |
|
| 2012 |
Emptage RP, Daughtry KD, Pemble CW, Raetz CR. Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface. Proceedings of the National Academy of Sciences of the United States of America. 109: 12956-61. PMID 22826246 DOI: 10.1073/Pnas.1206072109 |
0.454 |
|
| 2012 |
Kong Q, Six DA, Liu Q, Gu L, Wang S, Alamuri P, Raetz CR, Curtiss R. Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity. Infection and Immunity. 80: 3215-24. PMID 22753374 DOI: 10.1128/Iai.00123-12 |
0.771 |
|
| 2012 |
Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK. LPS remodeling is an evolved survival strategy for bacteria. Proceedings of the National Academy of Sciences of the United States of America. 109: 8716-21. PMID 22586119 DOI: 10.1073/Pnas.1202908109 |
0.496 |
|
| 2012 |
Six DA, Lambert B, Raetz CR, Doerrler WT. Density gradient enrichment of Escherichia coli lpxL mutants. Biochimica Et Biophysica Acta. 1821: 989-93. PMID 22554681 DOI: 10.1016/J.Bbalip.2012.04.003 |
0.736 |
|
| 2012 |
Joo SH, Chung HS, Raetz CR, Garrett TA. Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase. Biochemistry. 51: 4322-30. PMID 22545860 DOI: 10.1021/Bi3002242 |
0.542 |
|
| 2012 |
Gründahl JE, Guan Z, Rust S, Reunert J, Müller B, Du Chesne I, Zerres K, Rudnik-Schöneborn S, Ortiz-Brüchle N, Häusler MG, Siedlecka J, Swiezewska E, Raetz CR, Marquardt T. Life with too much polyprenol: polyprenol reductase deficiency. Molecular Genetics and Metabolism. 105: 642-51. PMID 22304929 DOI: 10.1016/J.Ymgme.2011.12.017 |
0.336 |
|
| 2012 |
Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infection and Immunity. 80: 943-51. PMID 22215738 DOI: 10.1128/Iai.06109-11 |
0.348 |
|
| 2012 |
Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. LpxI: A Novel Phosphosaccharolipid Hydrolase Biophysical Journal. 102: 303a. DOI: 10.1016/J.Bpj.2011.11.1675 |
0.759 |
|
| 2011 |
Kong Q, Six DA, Liu Q, Gu L, Roland KL, Raetz CR, Curtiss R. Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant. Infection and Immunity. 79: 5027-38. PMID 21930761 DOI: 10.1128/Iai.05524-11 |
0.726 |
|
| 2011 |
Garrett TA, Raetz CR, Son JD, Richardson TD, Bartling C, Guan Z. Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts. Biochimica Et Biophysica Acta. 1811: 827-37. PMID 21925285 DOI: 10.1016/J.Bbalip.2011.08.012 |
0.805 |
|
| 2011 |
Haig NA, Guan Z, Li D, McMichael A, Raetz CR, Xu XN. Identification of self-lipids presented by CD1c and CD1d proteins. The Journal of Biological Chemistry. 286: 37692-701. PMID 21900247 DOI: 10.1074/Jbc.M111.267948 |
0.371 |
|
| 2011 |
Li C, Guan Z, Liu D, Raetz CR. Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 11387-92. PMID 21709257 DOI: 10.1073/Pnas.1108840108 |
0.525 |
|
| 2011 |
Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metabolism. 13: 690-700. PMID 21641550 DOI: 10.1016/J.Cmet.2011.04.007 |
0.33 |
|
| 2011 |
Kong Q, Six DA, Roland KL, Liu Q, Gu L, Reynolds CM, Wang X, Raetz CR, Curtiss R. Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity. Journal of Immunology (Baltimore, Md. : 1950). 187: 412-23. PMID 21632711 DOI: 10.4049/Jimmunol.1100339 |
0.737 |
|
| 2011 |
Nguyen BD, Cunningham D, Liang X, Chen X, Toone EJ, Raetz CR, Zhou P, Valdivia RH. Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis. Proceedings of the National Academy of Sciences of the United States of America. 108: 10284-9. PMID 21628561 DOI: 10.1073/Pnas.1107478108 |
0.484 |
|
| 2011 |
Sun W, Six D, Kuang X, Roland KL, Raetz CR, Curtiss R. A live attenuated strain of Yersinia pestis KIM as a vaccine against plague. Vaccine. 29: 2986-98. PMID 21320544 DOI: 10.1016/J.Vaccine.2011.01.099 |
0.737 |
|
| 2011 |
Guan Z, Johnston NC, Aygun-Sunar S, Daldal F, Raetz CR, Goldfine H. Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens. Biochimica Et Biophysica Acta. 1811: 186-93. PMID 21195206 DOI: 10.1016/J.Bbalip.2010.12.010 |
0.428 |
|
| 2011 |
Liang X, Lee CJ, Chen X, Chung HS, Zeng D, Raetz CR, Li Y, Zhou P, Toone EJ. Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorganic & Medicinal Chemistry. 19: 852-60. PMID 21194954 DOI: 10.1016/J.Bmc.2010.12.017 |
0.386 |
|
| 2011 |
Chung HS, Raetz CR. Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 108: 510-5. PMID 21178073 DOI: 10.1073/Pnas.1016462108 |
0.444 |
|
| 2011 |
Lee CJ, Liang X, Chen X, Zeng D, Joo SH, Chung HS, Barb AW, Swanson SM, Nicholas RA, Li Y, Toone EJ, Raetz CR, Zhou P. Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chemistry & Biology. 18: 38-47. PMID 21167751 DOI: 10.1016/J.Chembiol.2010.11.011 |
0.699 |
|
| 2011 |
Lu YH, Guan Z, Zhao J, Raetz CR. Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. The Journal of Biological Chemistry. 286: 5506-18. PMID 21148555 DOI: 10.1074/Jbc.M110.199265 |
0.468 |
|
| 2011 |
Guan Z, Wang X, Raetz CR. Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium. Analytical Biochemistry. 409: 284-9. PMID 21050835 DOI: 10.1016/J.Ab.2010.10.035 |
0.361 |
|
| 2010 |
Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, et al. A mouse macrophage lipidome. The Journal of Biological Chemistry. 285: 39976-85. PMID 20923771 DOI: 10.1074/Jbc.M110.182915 |
0.594 |
|
| 2010 |
Ingram BO, Masoudi A, Raetz CR. Escherichia coli mutants that synthesize dephosphorylated lipid A molecules. Biochemistry. 49: 8325-37. PMID 20795687 DOI: 10.1021/Bi101253S |
0.552 |
|
| 2010 |
Rush JS, Matveev S, Guan Z, Raetz CR, Waechter CJ. Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells. Glycobiology. 20: 1585-93. PMID 20685834 DOI: 10.1093/Glycob/Cwq107 |
0.356 |
|
| 2010 |
Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, ... Raetz CR, et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. Journal of Lipid Research. 51: 3299-305. PMID 20671299 DOI: 10.1194/Jlr.M009449 |
0.761 |
|
| 2010 |
Zhao J, Raetz CR. A two-component Kdo hydrolase in the inner membrane of Francisella novicida. Molecular Microbiology. 78: 820-36. PMID 20662782 DOI: 10.1111/J.1365-2958.2010.07305.X |
0.526 |
|
| 2010 |
Stead CM, Zhao J, Raetz CR, Trent MS. Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface. Molecular Microbiology. 78: 837-52. PMID 20659292 DOI: 10.1111/J.1365-2958.2010.07304.X |
0.464 |
|
| 2010 |
Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blümel P, Sykut-Cegielska J, Houliston S, Swistun D, ... ... Raetz CR, et al. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 142: 203-17. PMID 20637498 DOI: 10.1016/J.Cell.2010.06.001 |
0.365 |
|
| 2010 |
Metzger LE, Raetz CR. An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis. Biochemistry. 49: 6715-26. PMID 20608695 DOI: 10.1021/Bi1008744 |
0.765 |
|
| 2010 |
Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, ... Raetz CR, et al. Subcellular organelle lipidomics in TLR-4-activated macrophages. Journal of Lipid Research. 51: 2785-97. PMID 20574076 DOI: 10.1194/Jlr.M008748 |
0.615 |
|
| 2010 |
Bodewits K, Raetz CR, Govan JR, Campopiano DJ. Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex. Antimicrobial Agents and Chemotherapy. 54: 3531-3. PMID 20516283 DOI: 10.1128/Aac.01600-09 |
0.415 |
|
| 2010 |
Chung HS, Raetz CR. Interchangeable domains in the Kdo transferases of Escherichia coli and Haemophilus influenzae. Biochemistry. 49: 4126-37. PMID 20394418 DOI: 10.1021/Bi100343E |
0.567 |
|
| 2010 |
Grabi?ska KA, Cui J, Chatterjee A, Guan Z, Raetz CR, Robbins PW, Samuelson J. Molecular characterization of the cis-prenyltransferase of Giardia lamblia. Glycobiology. 20: 824-32. PMID 20308470 DOI: 10.1093/Glycob/Cwq036 |
0.406 |
|
| 2010 |
Johnston NC, Aygun-Sunar S, Guan Z, Ribeiro AA, Daldal F, Raetz CR, Goldfine H. A phosphoethanolamine-modified glycosyl diradylglycerol in the polar lipids of Clostridium tetani. Journal of Lipid Research. 51: 1953-61. PMID 20173213 DOI: 10.1194/Jlr.M004788 |
0.401 |
|
| 2010 |
Ingram BO, Sohlenkamp C, Geiger O, Raetz CR. Altered lipid A structures and polymyxin hypersensitivity of Rhizobium etli mutants lacking the LpxE and LpxF phosphatases. Biochimica Et Biophysica Acta. 1801: 593-604. PMID 20153447 DOI: 10.1016/J.Bbalip.2010.02.001 |
0.526 |
|
| 2010 |
Zavaleta-Pastor M, Sohlenkamp C, Gao JL, Guan Z, Zaheer R, Finan TM, Raetz CR, López-Lara IM, Geiger O. Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation. Proceedings of the National Academy of Sciences of the United States of America. 107: 302-7. PMID 20018679 DOI: 10.1073/Pnas.0912930107 |
0.511 |
|
| 2010 |
Barb AW, Jiang L, Raetz CR, Zhou P. Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240. Biomolecular Nmr Assignments. 4: 37-40. PMID 19941092 DOI: 10.1007/S12104-009-9201-5 |
0.696 |
|
| 2010 |
Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. Application of proteomic marker ensembles to subcellular organelle identification. Molecular & Cellular Proteomics : McP. 9: 388-402. PMID 19884172 DOI: 10.1074/Mcp.M900432-Mcp200 |
0.526 |
|
| 2009 |
Metzger LE, Raetz CR. Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein. Biochemistry. 48: 11559-71. PMID 19883124 DOI: 10.1021/Bi901750F |
0.755 |
|
| 2009 |
Reynolds CM, Raetz CR. Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. Biochemistry. 48: 9627-40. PMID 19754149 DOI: 10.1021/Bi901391G |
0.534 |
|
| 2009 |
Bartling CM, Raetz CR. Crystal structure and acyl chain selectivity of Escherichia coli LpxD, the N-acyltransferase of lipid A biosynthesis. Biochemistry. 48: 8672-83. PMID 19655786 DOI: 10.1021/Bi901025V |
0.826 |
|
| 2009 |
Robins LI, Williams AH, Raetz CR. Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry. 48: 6191-201. PMID 19456129 DOI: 10.1021/Bi900629E |
0.54 |
|
| 2009 |
Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi CR, Raetz CR. Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry. 48: 3068-77. PMID 19256534 DOI: 10.1021/Bi900167Q |
0.803 |
|
| 2009 |
Rutten L, Mannie JP, Stead CM, Raetz CR, Reynolds CM, Bonvin AM, Tommassen JP, Egmond MR, Trent MS, Gros P. Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium. Proceedings of the National Academy of Sciences of the United States of America. 106: 1960-4. PMID 19174515 DOI: 10.1073/Pnas.0813064106 |
0.484 |
|
| 2009 |
Wang X, Ribeiro AA, Guan Z, Raetz CR. Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification. Biochemistry. 48: 1162-72. PMID 19166327 DOI: 10.1021/Bi802211K |
0.484 |
|
| 2009 |
Song F, Guan Z, Raetz CR. Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida. Biochemistry. 48: 1173-82. PMID 19166326 DOI: 10.1021/Bi802212T |
0.432 |
|
| 2009 |
Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. Update of the LIPID MAPS comprehensive classification system for lipids. Journal of Lipid Research. 50: S9-14. PMID 19098281 DOI: 10.1194/Jlr.R800095-Jlr200 |
0.589 |
|
| 2009 |
Garrett TA, Raetz CR, Richardson T, Kordestani R, Son JD, Rose RL. Identification of phosphatidylserylglutamate: a novel minor lipid in Escherichia coli. Journal of Lipid Research. 50: 1589-99. PMID 19096047 DOI: 10.1194/Jlr.M800549-Jlr200 |
0.387 |
|
| 2009 |
Karbarz MJ, Six DA, Raetz CR. Purification and characterization of the lipid A 1-phosphatase LpxE of Rhizobium leguminosarum. The Journal of Biological Chemistry. 284: 414-25. PMID 18984595 DOI: 10.1074/Jbc.M808390200 |
0.841 |
|
| 2009 |
Raetz CR, Guan Z, Ingram BO, Six DA, Song F, Wang X, Zhao J. Discovery of new biosynthetic pathways: the lipid A story. Journal of Lipid Research. 50: S103-8. PMID 18974037 DOI: 10.1194/Jlr.R800060-Jlr200 |
0.762 |
|
| 2009 |
Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi CR, Raetz C. Correction to uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC (Biochemistry (2009) 48, (3068) DOI: 10.1021/bi900167q) Biochemistry. 48: 7776. DOI: 10.1021/Bi9012066 |
0.782 |
|
| 2008 |
Ma B, Reynolds CM, Raetz CR. Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant. Proceedings of the National Academy of Sciences of the United States of America. 105: 13823-8. PMID 18768814 DOI: 10.1073/Pnas.0807028105 |
0.475 |
|
| 2008 |
Six DA, Carty SM, Guan Z, Raetz CR. Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. Biochemistry. 47: 8623-37. PMID 18656959 DOI: 10.1021/Bi800873N |
0.797 |
|
| 2008 |
Grabi?ska KA, Ghosh SK, Guan Z, Cui J, Raetz CR, Robbins PW, Samuelson J. Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis. Eukaryotic Cell. 7: 1344-51. PMID 18552282 DOI: 10.1128/Ec.00061-08 |
0.358 |
|
| 2008 |
Bartling CM, Raetz CR. Steady-state kinetics and mechanism of LpxD, the N-acyltransferase of lipid A biosynthesis. Biochemistry. 47: 5290-302. PMID 18422345 DOI: 10.1021/Bi800240R |
0.793 |
|
| 2008 |
Gibbons HS, Reynolds CM, Guan Z, Raetz CR. An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A. Biochemistry. 47: 2814-25. PMID 18254598 DOI: 10.1021/Bi702457C |
0.754 |
|
| 2008 |
Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/J.Molcel.2007.11.026 |
0.368 |
|
| 2007 |
Guan Z, Li S, Smith DC, Shaw WA, Raetz CR. Identification of N-acylphosphatidylserine molecules in eukaryotic cells. Biochemistry. 46: 14500-13. PMID 18031065 DOI: 10.1021/Bi701907G |
0.337 |
|
| 2007 |
Barb AW, Jiang L, Raetz CR, Zhou P. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 18433-8. PMID 18025458 DOI: 10.1073/Pnas.0709412104 |
0.716 |
|
| 2007 |
Sohlenkamp C, Galindo-Lagunas KA, Guan Z, Vinuesa P, Robinson S, Thomas-Oates J, Raetz CR, Geiger O. The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions. Molecular Plant-Microbe Interactions : Mpmi. 20: 1421-30. PMID 17977153 DOI: 10.1094/Mpmi-20-11-1421 |
0.46 |
|
| 2007 |
Garrett TA, Guan Z, Raetz CR. Analysis of ubiquinones, dolichols, and dolichol diphosphate-oligosaccharides by liquid chromatography-electrospray ionization-mass spectrometry. Methods in Enzymology. 432: 117-43. PMID 17954215 DOI: 10.1016/S0076-6879(07)32005-3 |
0.365 |
|
| 2007 |
Yan A, Guan Z, Raetz CR. An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. The Journal of Biological Chemistry. 282: 36077-89. PMID 17928292 DOI: 10.1074/Jbc.M706172200 |
0.433 |
|
| 2007 |
Williams AH, Raetz CR. Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 104: 13543-50. PMID 17698807 DOI: 10.1073/Pnas.0705833104 |
0.575 |
|
| 2007 |
Raetz CR, Reynolds CM, Trent MS, Bishop RE. Lipid A modification systems in gram-negative bacteria. Annual Review of Biochemistry. 76: 295-329. PMID 17362200 DOI: 10.1146/Annurev.Biochem.76.010307.145803 |
0.52 |
|
| 2007 |
Wang X, Ribeiro AA, Guan Z, Abraham SN, Raetz CR. Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 104: 4136-41. PMID 17360489 DOI: 10.1073/Pnas.0611606104 |
0.406 |
|
| 2007 |
Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 46: 3793-802. PMID 17335290 DOI: 10.1021/Bi6025165 |
0.83 |
|
| 2007 |
Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. LMSD: LIPID MAPS structure database. Nucleic Acids Research. 35: D527-32. PMID 17098933 DOI: 10.1093/Nar/Gkl838 |
0.567 |
|
| 2006 |
Wang X, Ribeiro AA, Guan Z, McGrath SC, Cotter RJ, Raetz CR. Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida. Biochemistry. 45: 14427-40. PMID 17128982 DOI: 10.1021/Bi061767S |
0.382 |
|
| 2006 |
Schaaf G, Betts L, Garrett TA, Raetz CR, Bankaitis VA. Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1156-60. PMID 17077504 DOI: 10.1107/S1744309106041728 |
0.35 |
|
| 2006 |
Williams AH, Immormino RM, Gewirth DT, Raetz CR. Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proceedings of the National Academy of Sciences of the United States of America. 103: 10877-82. PMID 16835299 DOI: 10.1073/Pnas.0604465103 |
0.544 |
|
| 2006 |
Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 50: 2178-84. PMID 16723580 DOI: 10.1128/Aac.00140-06 |
0.813 |
|
| 2006 |
Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ, Raetz CR, Trent MS. An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A. The Journal of Biological Chemistry. 281: 21974-87. PMID 16704973 DOI: 10.1074/Jbc.M603527200 |
0.536 |
|
| 2006 |
Kanjilal-Kolar S, Basu SS, Kanipes MI, Guan Z, Garrett TA, Raetz CR. Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases. The Journal of Biological Chemistry. 281: 12865-78. PMID 16497674 DOI: 10.1074/Jbc.M513864200 |
0.518 |
|
| 2006 |
Kanjilal-Kolar S, Raetz CR. Dodecaprenyl phosphate-galacturonic acid as a donor substrate for lipopolysaccharide core glycosylation in Rhizobium leguminosarum. The Journal of Biological Chemistry. 281: 12879-87. PMID 16497671 DOI: 10.1074/Jbc.M513865200 |
0.553 |
|
| 2006 |
Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, et al. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Journal of Lipid Research. 47: 1097-111. PMID 16479018 DOI: 10.1194/Jlr.M600027-Jlr200 |
0.615 |
|
| 2006 |
Wang X, McGrath SC, Cotter RJ, Raetz CR. Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF. The Journal of Biological Chemistry. 281: 9321-30. PMID 16467300 DOI: 10.1074/Jbc.M600435200 |
0.547 |
|
| 2005 |
McClerren AL, Endsley S, Bowman JL, Andersen NH, Guan Z, Rudolph J, Raetz CR. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin. Biochemistry. 44: 16574-83. PMID 16342948 DOI: 10.1021/Bi0518186 |
0.828 |
|
| 2005 |
Nahori MA, Fournié-Amazouz E, Que-Gewirth NS, Balloy V, Chignard M, Raetz CR, Saint Girons I, Werts C. Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 6022-31. PMID 16237097 DOI: 10.4049/Jimmunol.175.9.6022 |
0.359 |
|
| 2005 |
Guan Z, Breazeale SD, Raetz CR. Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli. Analytical Biochemistry. 345: 336-9. PMID 16118008 DOI: 10.1016/J.Ab.2005.07.002 |
0.452 |
|
| 2005 |
Murphy RC, Raetz CR, Reynolds CM, Barkley RM. Mass spectrometry advances in lipidomica: collision-induced decomposition of Kdo2-lipid A. Prostaglandins & Other Lipid Mediators. 77: 131-40. PMID 16099398 DOI: 10.1016/J.Prostaglandins.2004.09.004 |
0.428 |
|
| 2005 |
Boon Hinckley M, Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ, Lauw FN, Golenbock DT, Raetz CR. A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A. The Journal of Biological Chemistry. 280: 30214-24. PMID 15994324 DOI: 10.1074/Jbc.M506103200 |
0.437 |
|
| 2005 |
Doerrler WT, Raetz CR. Loss of outer membrane proteins without inhibition of lipid export in an Escherichia coli YaeT mutant. The Journal of Biological Chemistry. 280: 27679-87. PMID 15951436 DOI: 10.1074/Jbc.M504796200 |
0.463 |
|
| 2005 |
Tran AX, Lester ME, Stead CM, Raetz CR, Maskell DJ, McGrath SC, Cotter RJ, Trent MS. Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A. The Journal of Biological Chemistry. 280: 28186-94. PMID 15951433 DOI: 10.1074/Jbc.M505020200 |
0.486 |
|
| 2005 |
Williams GJ, Breazeale SD, Raetz CR, Naismith JH. Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. The Journal of Biological Chemistry. 280: 23000-8. PMID 15809294 DOI: 10.1074/Jbc.M501534200 |
0.392 |
|
| 2005 |
Reynolds CM, Kalb SR, Cotter RJ, Raetz CR. A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant. The Journal of Biological Chemistry. 280: 21202-11. PMID 15795227 DOI: 10.1074/Jbc.M500964200 |
0.392 |
|
| 2005 |
Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, et al. A comprehensive classification system for lipids. Journal of Lipid Research. 46: 839-61. PMID 15722563 DOI: 10.1194/Jlr.E400004-Jlr200 |
0.626 |
|
| 2005 |
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. The Journal of Biological Chemistry. 280: 14154-67. PMID 15695810 DOI: 10.1074/Jbc.M414265200 |
0.791 |
|
| 2005 |
Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J, Hindsgaul O, Raetz CR, Zhou P. Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. Biochemistry. 44: 1114-26. PMID 15667205 DOI: 10.1021/Bi047820Z |
0.8 |
|
| 2005 |
McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. Biochemistry. 44: 1106-13. PMID 15667204 DOI: 10.1021/Bi048001H |
0.77 |
|
| 2005 |
Gibbons HS, Kalb SR, Cotter RJ, Raetz CR. Role of Mg2+ and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Molecular Microbiology. 55: 425-40. PMID 15659161 DOI: 10.1111/J.1365-2958.2004.04409.X |
0.732 |
|
| 2004 |
Jain NU, Wyckoff TJ, Raetz CR, Prestegard JH. Rapid analysis of large protein-protein complexes using NMR-derived orientational constraints: the 95 kDa complex of LpxA with acyl carrier protein. Journal of Molecular Biology. 343: 1379-89. PMID 15491619 DOI: 10.1016/J.Jmb.2004.08.103 |
0.325 |
|
| 2004 |
Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS. Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. The Journal of Biological Chemistry. 279: 55780-91. PMID 15489235 DOI: 10.1074/Jbc.M406480200 |
0.805 |
|
| 2004 |
Wang X, Karbarz MJ, McGrath SC, Cotter RJ, Raetz CR. MsbA transporter-dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane: topography of francisella novicida LpxE expressed in Escherichia coli. The Journal of Biological Chemistry. 279: 49470-8. PMID 15339914 DOI: 10.1074/Jbc.M409078200 |
0.827 |
|
| 2004 |
Doerrler WT, Gibbons HS, Raetz CR. MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli. The Journal of Biological Chemistry. 279: 45102-9. PMID 15304478 DOI: 10.1074/Jbc.M408106200 |
0.755 |
|
| 2004 |
Sweet CR, Ribeiro AA, Raetz CR. Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains. The Journal of Biological Chemistry. 279: 25400-10. PMID 15044494 DOI: 10.1074/Jbc.M400596200 |
0.469 |
|
| 2004 |
Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR. Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group. The Journal of Biological Chemistry. 279: 25411-9. PMID 15044493 DOI: 10.1074/Jbc.M400597200 |
0.828 |
|
| 2004 |
Que-Gewirth NL, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM, Adler B, Girons IS, Werts C, Raetz CR. A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2. The Journal of Biological Chemistry. 279: 25420-9. PMID 15044492 DOI: 10.1074/Jbc.M400598200 |
0.484 |
|
| 2003 |
Karbarz MJ, Kalb SR, Cotter RJ, Raetz CR. Expression cloning and biochemical characterization of a Rhizobium leguminosarum lipid A 1-phosphatase. The Journal of Biological Chemistry. 278: 39269-79. PMID 12869541 DOI: 10.1074/Jbc.M305830200 |
0.814 |
|
| 2003 |
Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. Nature Structural Biology. 10: 645-51. PMID 12833153 DOI: 10.1038/Nsb948 |
0.792 |
|
| 2003 |
Breazeale SD, Ribeiro AA, Raetz CR. Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose. The Journal of Biological Chemistry. 278: 24731-9. PMID 12704196 DOI: 10.1074/Jbc.M304043200 |
0.436 |
|
| 2003 |
Kanipes MI, Ribeiro AA, Lin S, Cotter RJ, Raetz CR. A mannosyl transferase required for lipopolysaccharide inner core assembly in Rhizobium leguminosarum. Purification, substrate specificity, and expression in Salmonella waaC mutants. The Journal of Biological Chemistry. 278: 16356-64. PMID 12591937 DOI: 10.1074/Jbc.M301255200 |
0.446 |
|
| 2003 |
Kanipes MI, Kalb SR, Cotter RJ, Hozbor DF, Lagares A, Raetz CR. Relaxed sugar donor selectivity of a Sinorhizobium meliloti ortholog of the Rhizobium leguminosarum mannosyl transferase LpcC. Role of the lipopolysaccharide core in symbiosis of Rhizobiaceae with plants. The Journal of Biological Chemistry. 278: 16365-71. PMID 12591936 DOI: 10.1074/Jbc.M301256200 |
0.409 |
|
| 2003 |
Li X, Uchiyama T, Raetz CR, Hindsgaul O. Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis. Organic Letters. 5: 539-41. PMID 12583763 DOI: 10.1021/Ol027458L |
0.472 |
|
| 2003 |
Pirrung MC, Tumey LN, McClerren AL, Raetz CR. High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties. Journal of the American Chemical Society. 125: 1575-86. PMID 12568618 DOI: 10.1021/Ja0209114 |
0.787 |
|
| 2003 |
Que-Gewirth NL, Karbarz MJ, Kalb SR, Cotter RJ, Raetz CR. Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ. The Journal of Biological Chemistry. 278: 12120-9. PMID 12531908 DOI: 10.1074/Jbc.M300379200 |
0.808 |
|
| 2003 |
Que-Gewirth NL, Lin S, Cotter RJ, Raetz CR. An outer membrane enzyme that generates the 2-amino-2-deoxy-gluconate moiety of Rhizobium leguminosarum lipid A. The Journal of Biological Chemistry. 278: 12109-19. PMID 12531907 DOI: 10.1074/Jbc.M300378200 |
0.453 |
|
| 2002 |
Hwang PM, Choy WY, Lo EI, Chen L, Forman-Kay JD, Raetz CR, Privé GG, Bishop RE, Kay LE. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proceedings of the National Academy of Sciences of the United States of America. 99: 13560-5. PMID 12357033 DOI: 10.1073/Pnas.212344499 |
0.466 |
|
| 2002 |
Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. Journal of Medicinal Chemistry. 45: 4359-70. PMID 12213077 DOI: 10.1021/Jm020183V |
0.805 |
|
| 2002 |
Doerrler WT, Raetz CR. ATPase activity of the MsbA lipid flippase of Escherichia coli. The Journal of Biological Chemistry. 277: 36697-705. PMID 12119303 DOI: 10.1074/Jbc.M205857200 |
0.544 |
|
| 2002 |
Kline T, Andersen NH, Harwood EA, Bowman J, Malanda A, Endsley S, Erwin AL, Doyle M, Fong S, Harris AL, Mendelsohn B, Mdluli K, Raetz CR, Stover CK, Witte PR, et al. Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC. Journal of Medicinal Chemistry. 45: 3112-29. PMID 12086497 DOI: 10.1021/Jm010579R |
0.414 |
|
| 2002 |
Raetz CR, Whitfield C. Lipopolysaccharide endotoxins. Annual Review of Biochemistry. 71: 635-700. PMID 12045108 DOI: 10.1146/annurev.biochem.71.110601.135414 |
0.363 |
|
| 2002 |
Basu SS, Karbarz MJ, Raetz CR. Expression cloning and characterization of the C28 acyltransferase of lipid A biosynthesis in Rhizobium leguminosarum. The Journal of Biological Chemistry. 277: 28959-71. PMID 12019272 DOI: 10.1074/Jbc.M204525200 |
0.821 |
|
| 2002 |
Babinski KJ, Kanjilal SJ, Raetz CR. Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene. The Journal of Biological Chemistry. 277: 25947-56. PMID 12000771 DOI: 10.1074/Jbc.M204068200 |
0.819 |
|
| 2002 |
Babinski KJ, Ribeiro AA, Raetz CR. The Escherichia coli gene encoding the UDP-2,3-diacylglucosamine pyrophosphatase of lipid A biosynthesis. The Journal of Biological Chemistry. 277: 25937-46. PMID 12000770 DOI: 10.1074/Jbc.M204067200 |
0.825 |
|
| 2002 |
Sweet CR, Preston A, Toland E, Ramirez SM, Cotter RJ, Maskell DJ, Raetz CR. Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases. The Journal of Biological Chemistry. 277: 18281-90. PMID 11889134 DOI: 10.1074/Jbc.M201057200 |
0.47 |
|
| 2002 |
Vorachek-Warren MK, Ramirez S, Cotter RJ, Raetz CR. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. The Journal of Biological Chemistry. 277: 14194-205. PMID 11830595 DOI: 10.1074/Jbc.M200409200 |
0.834 |
|
| 2002 |
Vorachek-Warren MK, Carty SM, Lin S, Cotter RJ, Raetz CR. An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. The Journal of Biological Chemistry. 277: 14186-93. PMID 11830594 DOI: 10.1074/Jbc.M200408200 |
0.819 |
|
| 2002 |
Breazeale SD, Ribeiro AA, Raetz CR. Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. The Journal of Biological Chemistry. 277: 2886-96. PMID 11706007 DOI: 10.1074/Jbc.M109377200 |
0.416 |
|
| 2001 |
Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter RJ, Raetz CR. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. The Journal of Biological Chemistry. 276: 43132-44. PMID 11535605 DOI: 10.1074/Jbc.M106962200 |
0.371 |
|
| 2001 |
Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CR. An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. The Journal of Biological Chemistry. 276: 43122-31. PMID 11535604 DOI: 10.1074/Jbc.M106961200 |
0.422 |
|
| 2001 |
Zhou Z, Ribeiro AA, Lin S, Cotter RJ, Miller SI, Raetz CR. Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation. The Journal of Biological Chemistry. 276: 43111-21. PMID 11535603 DOI: 10.1074/Jbc.M106960200 |
0.48 |
|
| 2001 |
Raetz CR. Regulated covalent modifications of lipid A. Journal of Endotoxin Research. 7: 73-8. PMID 11521087 DOI: 10.1177/09680519010070010201 |
0.572 |
|
| 2001 |
Sweet CR, Lin S, Cotter RJ, Raetz CR. A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species. The Journal of Biological Chemistry. 276: 19565-74. PMID 11279221 DOI: 10.1074/Jbc.M101868200 |
0.469 |
|
| 2001 |
Doerrler WT, Reedy MC, Raetz CR. An Escherichia coli mutant defective in lipid export. The Journal of Biological Chemistry. 276: 11461-4. PMID 11278265 DOI: 10.1074/Jbc.C100091200 |
0.452 |
|
| 2001 |
Jackman JE, Raetz CR, Fierke CA. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site. Biochemistry. 40: 514-23. PMID 11148046 DOI: 10.1021/Bi001872G |
0.772 |
|
| 2001 |
Kanipes MI, Lin S, Cotter RJ, Raetz CR. Ca2+-induced phosphoethanolamine transfer to the outer 3-deoxy-D-manno-octulosonic acid moiety of Escherichia coli lipopolysaccharide. A novel membrane enzyme dependent upon phosphatidylethanolamine. The Journal of Biological Chemistry. 276: 1156-63. PMID 11042192 DOI: 10.1074/Jbc.M009019200 |
0.42 |
|
| 2000 |
Trent MS, Pabich W, Raetz CR, Miller SI. A PhoP/PhoQ-induced Lipase (PagL) that catalyzes 3-O-deacylation of lipid A precursors in membranes of Salmonella typhimurium. The Journal of Biological Chemistry. 276: 9083-92. PMID 11108722 DOI: 10.1074/Jbc.M010730200 |
0.473 |
|
| 2000 |
Bishop RE, Gibbons HS, Guina T, Trent MS, Miller SI, Raetz CR. Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria. The Embo Journal. 19: 5071-80. PMID 11013210 DOI: 10.1093/Emboj/19.19.5071 |
0.773 |
|
| 2000 |
Gibbons HS, Lin S, Cotter RJ, Raetz CR. Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue. The Journal of Biological Chemistry. 275: 32940-9. PMID 10903325 DOI: 10.1074/Jbc.M005779200 |
0.745 |
|
| 2000 |
Que NL, Ribeiro AA, Raetz CR. Two-dimensional NMR spectroscopy and structures of six lipid A species from Rhizobium etli CE3. Detection of an acyloxyacyl residue in each component and origin of the aminogluconate moiety. The Journal of Biological Chemistry. 275: 28017-27. PMID 10856304 DOI: 10.1074/Jbc.M004009200 |
0.45 |
|
| 2000 |
Que NL, Lin S, Cotter RJ, Raetz CR. Purification and mass spectrometry of six lipid A species from the bacterial endosymbiont Rhizobium etli. Demonstration of a conserved distal unit and a variable proximal portion. The Journal of Biological Chemistry. 275: 28006-16. PMID 10856303 DOI: 10.1074/Jbc.M004008200 |
0.406 |
|
| 2000 |
Zhou Z, Ribeiro AA, Raetz CR. High-resolution NMR spectroscopy of lipid A molecules containing 4-amino-4-deoxy-L-arabinose and phosphoethanolamine substituents. Different attachment sites on lipid A molecules from NH4VO3-treated Escherichia coli versus kdsA mutants of Salmonella typhimurium. The Journal of Biological Chemistry. 275: 13542-51. PMID 10788469 DOI: 10.1074/Jbc.275.18.13542 |
0.419 |
|
| 2000 |
Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs. The Journal of Biological Chemistry. 275: 11002-9. PMID 10753902 DOI: 10.1074/Jbc.275.15.11002 |
0.811 |
|
| 1999 |
Wyckoff TJ, Raetz CR. The active site of Escherichia coli UDP-N-acetylglucosamine acyltransferase. Chemical modification and site-directed mutagenesis. The Journal of Biological Chemistry. 274: 27047-55. PMID 10480918 DOI: 10.1074/Jbc.274.38.27047 |
0.483 |
|
| 1999 |
Zhou Z, Lin S, Cotter RJ, Raetz CR. Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate. The Journal of Biological Chemistry. 274: 18503-14. PMID 10373459 DOI: 10.1074/Jbc.274.26.18503 |
0.451 |
|
| 1999 |
Isobe T, White KA, Allen AG, Peacock M, Raetz CR, Maskell DJ. Bordetella pertussis waaA encodes a monofunctional 2-keto-3-deoxy-D-manno-octulosonic acid transferase that can complement an Escherichia coli waaA mutation. Journal of Bacteriology. 181: 2648-51. PMID 10198035 DOI: 10.1128/Jb.181.8.2648-2651.1999 |
0.394 |
|
| 1999 |
Basu SS, York JD, Raetz CR. A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. The Journal of Biological Chemistry. 274: 11139-49. PMID 10196199 DOI: 10.1074/Jbc.274.16.11139 |
0.497 |
|
| 1999 |
Carty SM, Sreekumar KR, Raetz CR. Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. The Journal of Biological Chemistry. 274: 9677-85. PMID 10092655 DOI: 10.1074/Jbc.274.14.9677 |
0.509 |
|
| 1999 |
Chen MH, Steiner MG, de Laszlo SE, Patchett AA, Anderson MS, Hyland SA, Onishi HR, Silver LL, Raetz CR. Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis. Bioorganic & Medicinal Chemistry Letters. 9: 313-8. PMID 10091675 DOI: 10.1016/S0960-894X(98)00749-5 |
0.491 |
|
| 1999 |
Garrett TA, Rosser MF, Raetz CR. Signal transduction triggered by lipid A-like molecules in 70Z/3 pre-B lymphocyte tumor cells. Biochimica Et Biophysica Acta. 1437: 246-56. PMID 10064907 DOI: 10.1016/S1388-1981(99)00014-1 |
0.346 |
|
| 1999 |
Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K, Young K, Su LH, Fierke CA, Jackman JE, Raetz CR, Coleman J, Tomoyasu T, Matsuzawa H. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Molecular Microbiology. 31: 833-44. PMID 10048027 DOI: 10.1046/J.1365-2958.1999.01221.X |
0.814 |
|
| 1999 |
Jackman JE, Raetz CR, Fierke CA. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme. Biochemistry. 38: 1902-11. PMID 10026271 DOI: 10.1021/Bi982339S |
0.761 |
|
| 1998 |
Kadrmas JL, Allaway D, Studholme RE, Sullivan JT, Ronson CW, Poole PS, Raetz CR. Cloning and overexpression of glycosyltransferases that generate the lipopolysaccharide core of Rhizobium leguminosarum. The Journal of Biological Chemistry. 273: 26432-40. PMID 9756877 DOI: 10.1074/Jbc.273.41.26432 |
0.494 |
|
| 1998 |
Wyckoff TJ, Raetz CR, Jackman JE. Antibacterial and anti-inflammatory agents that target endotoxin. Trends in Microbiology. 6: 154-9. PMID 9587193 DOI: 10.1016/S0966-842X(98)01230-X |
0.695 |
|
| 1998 |
Raetz CR. Enzymes of lipid A biosynthesis: targets for the design of new antibiotics Progress in Clinical and Biological Research. 397: 1-14. PMID 9575543 |
0.33 |
|
| 1998 |
Garrett TA, Que NL, Raetz CR. Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. The Journal of Biological Chemistry. 273: 12457-65. PMID 9575203 DOI: 10.1074/Jbc.273.20.12457 |
0.524 |
|
| 1998 |
Kadrmas JL, Raetz CR. Enzymatic synthesis of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase i. The Journal of Biological Chemistry. 273: 2799-807. PMID 9446588 DOI: 10.1074/Jbc.273.5.2799 |
0.525 |
|
| 1997 |
Garrett TA, Kadrmas JL, Raetz CR. Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. The Journal of Biological Chemistry. 272: 21855-64. PMID 9268317 DOI: 10.1074/Jbc.272.35.21855 |
0.475 |
|
| 1997 |
Clementz T, Zhou Z, Raetz CR. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. The Journal of Biological Chemistry. 272: 10353-60. PMID 9099672 DOI: 10.1074/Jbc.272.16.10353 |
0.53 |
|
| 1997 |
Milla ME, Raetz CR. Association of lipid A disaccharide synthase with aerobic glycerol-3-phosphate dehydrogenase in extracts of Escherichia coli. Biochimica Et Biophysica Acta. 1304: 245-53. PMID 8982270 DOI: 10.1016/S0005-2760(96)00124-5 |
0.453 |
|
| 1997 |
Brozek KA, Carlson RW, Raetz CR. A special acyl carrier protein for transferring long hydroxylated fatty acids to lipid A in Rhizobium. The Journal of Biological Chemistry. 271: 32126-36. PMID 8943266 DOI: 10.1074/Jbc.271.50.32126 |
0.53 |
|
| 1996 |
Onishi HR, Pelak BA, Gerckens LS, Silver LL, Kahan FM, Chen MH, Patchett AA, Galloway SM, Hyland SA, Anderson MS, Raetz CR. Antibacterial agents that inhibit lipid A biosynthesis. Science (New York, N.Y.). 274: 980-2. PMID 8875939 DOI: 10.1126/science.274.5289.980 |
0.438 |
|
| 1996 |
Sorensen PG, Lutkenhaus J, Young K, Eveland SS, Anderson MS, Raetz CR. Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis. The Journal of Biological Chemistry. 271: 25898-905. PMID 8824222 DOI: 10.1074/Jbc.271.42.25898 |
0.54 |
|
| 1996 |
Clementz T, Bednarski JJ, Raetz CR. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. The Journal of Biological Chemistry. 271: 12095-102. PMID 8662613 DOI: 10.1074/Jbc.271.20.12095 |
0.555 |
|
| 1996 |
Belunis CJ, Clementz T, Carty SM, Raetz CR. Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli. The Journal of Biological Chemistry. 270: 27646-52. PMID 7499229 DOI: 10.1074/Jbc.270.46.27646 |
0.535 |
|
| 1995 |
Young K, Silver LL, Bramhill D, Cameron P, Eveland SS, Raetz CR, Hyland SA, Anderson MS. The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase. The Journal of Biological Chemistry. 270: 30384-91. PMID 8530464 DOI: 10.1074/Jbc.270.51.30384 |
0.48 |
|
| 1995 |
Price NP, Jeyaretnam B, Carlson RW, Kadrmas JL, Raetz CR, Brozek KA. Lipid A biosynthesis in Rhizobium leguminosarum: role of a 2-keto-3-deoxyoctulosonate-activated 4' phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 92: 7352-6. PMID 7638195 DOI: 10.1073/Pnas.92.16.7352 |
0.552 |
|
| 1994 |
Mohan S, Raetz CR. Endotoxin biosynthesis in Pseudomonas aeruginosa: enzymatic incorporation of laurate before 3-deoxy-D-manno-octulosonate. Journal of Bacteriology. 176: 6944-51. PMID 7961456 DOI: 10.1128/jb.176.22.6944-6951.1994 |
0.442 |
|
| 1992 |
Brozek KA, Raetz CR. 3-deoxy-D-manno-octulosonate transferase and late acyltransferases of lipopolysaccharide biosynthesis. Methods in Enzymology. 209: 476-85. PMID 1495427 DOI: 10.1016/0076-6879(92)09058-B |
0.492 |
|
| 1992 |
Raetz CR. Lipid A disaccharide synthase from Escherichia coli. Methods in Enzymology. 209: 455-66. PMID 1495426 DOI: 10.1016/0076-6879(92)09056-9 |
0.549 |
|
| 1992 |
Anderson MS, Raetz CR. UDP-N-acetylglucosamine 3-O-acyltransferase from Escherichia coli. Methods in Enzymology. 209: 449-54. PMID 1495425 DOI: 10.1016/0076-6879(92)09055-8 |
0.478 |
|
| 1991 |
Williamson JM, Anderson MS, Raetz CR. Acyl-acyl carrier protein specificity of UDP-GlcNAc acyltransferases from gram-negative bacteria: relationship to lipid A structure. Journal of Bacteriology. 173: 3591-6. PMID 1904441 DOI: 10.1128/jb.173.11.3591-3596.1991 |
0.374 |
|
| 1990 |
Golenbock DT, Hampton RY, Raetz CR, Wright SD. Human phagocytes have multiple lipid A-binding sites. Infection and Immunity. 58: 4069-4075. DOI: 10.1128/iai.58.12.4069-4075.1990 |
0.628 |
|
| 1987 |
Raetz CR. Molecular genetics of membrane phospholipid synthesis. Annual Review of Genetics. 20: 253-95. PMID 3545060 DOI: 10.1146/annurev.ge.20.120186.001345 |
0.417 |
|
| 1986 |
Zoeller RA, Raetz CR. Isolation of animal cell mutants deficient in plasmalogen biosynthesis and peroxisome assembly. Proceedings of the National Academy of Sciences of the United States of America. 83: 5170-4. PMID 3460088 DOI: 10.1073/Pnas.83.14.5170 |
0.362 |
|
| 1985 |
Sparrow CP, Ganong BR, Raetz CR. Escherichia coli membrane vesicles with elevated phosphatidic acid levels. A detergent-free system for in vitro phospholipid synthesis. Biochimica Et Biophysica Acta. 796: 373-83. PMID 6391555 DOI: 10.1016/0005-2760(84)90140-1 |
0.366 |
|
| 1985 |
Nishijima M, Amano F, Akamatsu Y, Akagawa K, Tokunaga T, Raetz CR. Macrophage activation by monosaccharide precursors of Escherichia coli lipid A. Proceedings of the National Academy of Sciences of the United States of America. 82: 282-6. PMID 3881760 DOI: 10.1073/Pnas.82.2.282 |
0.42 |
|
| 1984 |
Raetz CR. The enzymatic synthesis of lipid A: molecular structure and biologic function of monosaccharide precursors. Reviews of Infectious Diseases. 6: 463-71. PMID 6382553 DOI: 10.1093/clinids/6.4.463 |
0.391 |
|
| 1983 |
Raetz CR, Purcell S, Takayama K. Molecular requirements for B-lymphocyte activation by Escherichia coli lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 80: 4624-8. PMID 6348772 DOI: 10.1073/Pnas.80.15.4624 |
0.464 |
|
| 1983 |
Icho T, Raetz CR. Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors. Journal of Bacteriology. 153: 722-730. DOI: 10.1128/jb.153.2.722-730.1983 |
0.31 |
|
| 1982 |
Esko JD, Nishijima M, Raetz CR. Animal cells dependent on exogenous phosphatidylcholine for membrane biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 79: 1698-702. PMID 6281780 DOI: 10.1073/Pnas.79.6.1698 |
0.453 |
|
| 1978 |
Esko JD, Raetz CR. Replica plating and in situ enzymatic assay of animal cell colonies established on filter paper. Proceedings of the National Academy of Sciences of the United States of America. 75: 1190-3. PMID 349559 DOI: 10.1073/Pnas.75.3.1190 |
0.316 |
|
| 1977 |
Raetz CR, Larson TJ, Dowhan W. Gene cloning for the isolation of enzymes of membrane lipid synthesis: phosphatidylserine synthase overproduction in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 74: 1412-1416. PMID 193099 DOI: 10.1073/Pnas.74.4.1412 |
0.395 |
|
| 1977 |
Raetz CR, Chu MY, Srivastava S, Turcotte JG. A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue. Science (New York, N.Y.). 196: 303-5. PMID 191910 DOI: 10.1126/Science.191910 |
0.329 |
|
| 1976 |
Raetz CR, Dowhan W, Kennedy EP. Partial purification and characterization of cytidine 5'-diphosphate-diglyceride hydrolase from membranes of Escherichia coli. Journal of Bacteriology. 125: 855-63. PMID 1254556 DOI: 10.1128/Jb.125.3.855-863.1976 |
0.619 |
|
| 1975 |
Raetz CR. Isolation of Escherichia coli mutants defective in enzymes of membrane lipid synthesis. Proceedings of the National Academy of Sciences of the United States of America. 72: 2274-8. PMID 49056 DOI: 10.1073/pnas.72.6.2274 |
0.306 |
|
| 1974 |
Raetz CR, Kennedy EP. Partial purification and properties of phosphatidylserine synthetase from Escherichia coli. The Journal of Biological Chemistry. 249: 5083-45. PMID 4604873 |
0.559 |
|
| 1973 |
Raetz CR, Kennedy EP. Function of cytidine diphosphate-diglyceride and deoxycytidine diphosphate-diglyceride in the biogenesis of membrane lipids in Escherichia coli. The Journal of Biological Chemistry. 248: 1098-105. PMID 4567788 |
0.648 |
|
| 1972 |
Raetz CR, Kennedy EP. The association of phosphatidylserine synthetase with ribosomes in extracts of Escherichia coli. The Journal of Biological Chemistry. 247: 2008-14. PMID 4552685 |
0.525 |
|
| 1972 |
Raetz CR, Hirschberg CB, Dowhan W, Wickner WT, Kennedy EP. A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride. The Journal of Biological Chemistry. 247: 2245-7. PMID 4335869 |
0.709 |
|
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