| Year |
Citation |
Score |
| 2024 |
He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G. Allosteric modulation and G-protein selectivity of the Ca-sensing receptor. Nature. PMID 38326620 DOI: 10.1038/s41586-024-07055-2 |
0.38 |
|
| 2023 |
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G. Structure-based discovery of positive allosteric modulators for the calcium sensing receptor. Biorxiv : the Preprint Server For Biology. PMID 38234749 DOI: 10.1101/2023.12.27.573448 |
0.307 |
|
| 2023 |
Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Álvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, ... ... Skiniotis G, et al. AlphaFold2 structures template ligand discovery. Biorxiv : the Preprint Server For Biology. PMID 38187536 DOI: 10.1101/2023.12.20.572662 |
0.792 |
|
| 2023 |
Vizurraga AL, Robertson MJ, Yu M, Skiniotis G, Tall GG. Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56. Molecular Pharmacology. 104: 28-41. PMID 37290962 DOI: 10.1124/molpharm.123.000688 |
0.555 |
|
| 2023 |
Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B. Structural basis for activation of CB1 by an endocannabinoid analog. Nature Communications. 14: 2672. PMID 37160876 DOI: 10.1038/s41467-023-37864-4 |
0.647 |
|
| 2023 |
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G protein activation by a GPCR. Biorxiv : the Preprint Server For Biology. PMID 36993214 DOI: 10.1101/2023.03.20.533387 |
0.834 |
|
| 2023 |
Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG. Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms. Structure (London, England : 1993). PMID 36931277 DOI: 10.1016/j.str.2023.02.011 |
0.818 |
|
| 2022 |
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, ... ... Skiniotis G, et al. Structure-based design of bitopic ligands for the µ-opioid receptor. Nature. PMID 36450356 DOI: 10.1038/s41586-022-05588-y |
0.785 |
|
| 2022 |
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, ... ... Skiniotis G, et al. Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature Chemical Biology. PMID 36411392 DOI: 10.1038/s41589-022-01208-y |
0.815 |
|
| 2022 |
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G. Structure determination of inactive-state GPCRs with a universal nanobody. Nature Structural & Molecular Biology. PMID 36396979 DOI: 10.1038/s41594-022-00859-8 |
0.82 |
|
| 2022 |
Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, ... ... Skiniotis G, et al. Bespoke library docking for 5-HT receptor agonists with antidepressant activity. Nature. PMID 36171289 DOI: 10.1038/s41586-022-05258-z |
0.8 |
|
| 2022 |
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, ... ... Skiniotis G, et al. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. PMID 36087581 DOI: 10.1016/j.neuron.2022.08.006 |
0.795 |
|
| 2022 |
Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD. Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nature Communications. 13: 5232. PMID 36064945 DOI: 10.1038/s41467-022-32822-y |
0.738 |
|
| 2022 |
Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G. Author Correction: Plasticity in ligand recognition at somatostatin receptors. Nature Structural & Molecular Biology. PMID 35804245 DOI: 10.1038/s41594-022-00813-8 |
0.539 |
|
| 2022 |
Robertson MJ, Skiniotis G. Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins. Journal of Chemical Theory and Computation. PMID 35687850 DOI: 10.1021/acs.jctc.2c00015 |
0.529 |
|
| 2022 |
Barros-Álvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, ... ... Skiniotis G, et al. The tethered peptide activation mechanism of adhesion GPCRs. Nature. PMID 35418682 DOI: 10.1038/s41586-022-04575-7 |
0.806 |
|
| 2022 |
Gmeiner P, Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK. Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists. Angewandte Chemie (International Ed. in English). PMID 35385593 DOI: 10.1002/anie.202200269 |
0.765 |
|
| 2022 |
Meyerowitz JG, Robertson MJ, Barros-Álvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G. The oxytocin signaling complex reveals a molecular switch for cation dependence. Nature Structural & Molecular Biology. PMID 35241813 DOI: 10.1038/s41594-022-00728-4 |
0.835 |
|
| 2022 |
Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G. Plasticity in ligand recognition at somatostatin receptors. Nature Structural & Molecular Biology. PMID 35210615 DOI: 10.1038/s41594-022-00727-5 |
0.616 |
|
| 2022 |
Tsutsumi N, Maeda S, Qu Q, Vögele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC. Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science Advances. 8: eabl5442. PMID 35061538 DOI: 10.1126/sciadv.abl5442 |
0.73 |
|
| 2021 |
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L. Structure and mechanism of the SGLT family of glucose transporters. Nature. PMID 34880492 DOI: 10.1038/s41586-021-04211-w |
0.743 |
|
| 2021 |
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA. Structural insights into GIRK2 channel modulation by cholesterol and PIP. Cell Reports. 36: 109619. PMID 34433062 DOI: 10.1016/j.celrep.2021.109619 |
0.79 |
|
| 2021 |
Robertson MJ, Meyerowitz JG, Skiniotis G. Drug discovery in the era of cryo-electron microscopy. Trends in Biochemical Sciences. PMID 34281791 DOI: 10.1016/j.tibs.2021.06.008 |
0.509 |
|
| 2021 |
Robertson MJ, Meyerowitz JG, Skiniotis G. Drug discovery in the era of cryo-electron microscopy. Trends in Biochemical Sciences. PMID 34281791 DOI: 10.1016/j.tibs.2021.06.008 |
0.509 |
|
| 2021 |
Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC. Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity. PMID 34216564 DOI: 10.1016/j.immuni.2021.06.001 |
0.775 |
|
| 2021 |
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Bräuner-Osborne H, Mathiesen JM, Skiniotis G. Asymmetric activation of the calcium-sensing receptor homodimer. Nature. PMID 34194040 DOI: 10.1038/s41586-021-03691-0 |
0.818 |
|
| 2021 |
Seven AB, Barros-Álvarez X, de Lapeyrière M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G. G-protein activation by a metabotropic glutamate receptor. Nature. PMID 34194039 DOI: 10.1038/s41586-021-03680-3 |
0.822 |
|
| 2021 |
Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA. Structure of the visual signaling complex between transducin and phosphodiesterase 6. Molecular Cell. 81: 2496. PMID 34087182 DOI: 10.1016/j.molcel.2021.05.006 |
0.772 |
|
| 2021 |
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell. 184: 983-999.e24. PMID 33606986 DOI: 10.1016/j.cell.2021.01.018 |
0.764 |
|
| 2020 |
Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Molecular Cell. PMID 33007200 DOI: 10.1016/j.molcel.2020.09.013 |
0.823 |
|
| 2020 |
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor. Cell. 182: 1574-1588.e19. PMID 32946782 DOI: 10.1016/J.Cell.2020.08.024 |
0.809 |
|
| 2020 |
Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK. Structural insights into differences in G protein activation by family A and family B GPCRs. Science (New York, N.Y.). 369. PMID 32732395 DOI: 10.1126/Science.Aba3373 |
0.741 |
|
| 2020 |
Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G. Structures of metabotropic GABA receptor. Nature. PMID 32580208 DOI: 10.1038/S41586-020-2469-4 |
0.81 |
|
| 2020 |
Robertson MJ, van Zundert GCP, Borrelli K, Skiniotis G. GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps. Structure (London, England : 1993). PMID 32413291 DOI: 10.1016/J.Str.2020.04.018 |
0.575 |
|
| 2020 |
Kan W, Enos MD, Korkmazhan E, Muennich S, Chen DH, Gammons MV, Vasishtha M, Bienz M, Dunn AR, Skiniotis G, Weis WI. Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction. Elife. 9. PMID 32297861 DOI: 10.7554/Elife.55015 |
0.338 |
|
| 2020 |
Wouters E, Walraed J, Robertson MJ, Meyrath M, Szpakowska M, Chevigné A, Skiniotis G, Stove C. Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds. Acs Pharmacology & Translational Science. 3: 285-295. PMID 32296768 DOI: 10.1021/acsptsci.9b00069 |
0.596 |
|
| 2020 |
Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G. Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Reports. PMID 32126208 DOI: 10.1016/J.Celrep.2020.02.086 |
0.79 |
|
| 2020 |
Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G. Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. Nature. PMID 31945772 DOI: 10.1038/S41586-020-1954-0 |
0.812 |
|
| 2020 |
Huang W, Masureel M, Qianhui Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK. Structure of the neurotensin receptor 1 in complex with β-arrestin 1. Nature. PMID 31945771 DOI: 10.1038/S41586-020-1953-1 |
0.693 |
|
| 2020 |
Glaaser IW, Mathiharan YK, Zhao Y, Skiniotis G, Slesinger PA. CRYO-EM Structures of the GIRK2 Channel Reveal Mechanisms for Lipid Modulation Biophysical Journal. 118: 497a-498a. DOI: 10.1016/J.Bpj.2019.11.2749 |
0.773 |
|
| 2019 |
Yang Y, Joshi M, Takahashi YH, Ning Z, Qu Q, Brunzelle JS, Skiniotis G, Figeys D, Shilatifard A, Couture JF. A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS. Nucleic Acids Research. PMID 31724694 DOI: 10.1093/Nar/Gkz1037 |
0.752 |
|
| 2019 |
Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G. Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Molecular Cell. PMID 31300275 DOI: 10.2210/Pdb6Oy9/Pdb |
0.795 |
|
| 2019 |
Chae PS, Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK. Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31243822 DOI: 10.1002/Chem.201902468 |
0.741 |
|
| 2019 |
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Conformational transitions of a neurotensin receptor 1-G complex. Nature. PMID 31243364 DOI: 10.1038/s41586-019-1337-6 |
0.744 |
|
| 2019 |
Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK. Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science (New York, N.Y.). 364: 552-557. PMID 31073061 DOI: 10.1126/Science.Aaw5188 |
0.818 |
|
| 2019 |
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, ... Skiniotis G, et al. Author Correction: Structural insights into the activation of metabotropic glutamate receptors. Nature. PMID 30814739 DOI: 10.1038/S41586-019-0983-Z |
0.784 |
|
| 2019 |
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, ... Skiniotis G, et al. Structural insights into the activation of metabotropic glutamate receptors. Nature. PMID 30675062 DOI: 10.1038/s41586-019-0881-4 |
0.835 |
|
| 2019 |
Kato HE, Zhang Y, Hu H, Suomivuori C, Kadji FMN, Aoki J, Kumar KK, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G. Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature. 572: 80-85. DOI: 10.2210/Pdb6Os9/Pdb |
0.77 |
|
| 2018 |
Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, ... Skiniotis G, et al. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell. PMID 30639101 DOI: 10.1016/J.Cell.2018.11.040 |
0.829 |
|
| 2018 |
Kappel K, Liu S, Larsen KP, Skiniotis G, Puglisi EV, Puglisi JD, Zhou ZH, Zhao R, Das R. De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes. Nature Methods. 15: 947-954. PMID 30377372 DOI: 10.1038/S41592-018-0172-2 |
0.312 |
|
| 2018 |
Haddad JF, Yang Y, Takahashi YH, Joshi M, Chaudhary N, Woodfin A, Benyoucef A, Yeung S, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation. Structure (London, England : 1993). PMID 30270175 DOI: 10.1016/J.Str.2018.08.004 |
0.346 |
|
| 2018 |
Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK. Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nature Communications. 9: 3712. PMID 30213947 DOI: 10.1038/S41467-018-06002-W |
0.729 |
|
| 2018 |
Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G. Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell. 174: 1117-1126.e12. PMID 30100186 DOI: 10.1016/J.Cell.2018.07.020 |
0.813 |
|
| 2018 |
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, ... Skiniotis G, et al. Structure of the µ-opioid receptor-G protein complex. Nature. PMID 29899455 DOI: 10.1038/S41586-018-0219-7 |
0.833 |
|
| 2018 |
Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV. Architecture of an HIV-1 reverse transcriptase initiation complex. Nature. PMID 29695867 DOI: 10.1038/S41586-018-0055-9 |
0.784 |
|
| 2018 |
Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D. Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell. 173: 735-748.e15. PMID 29677516 DOI: 10.1016/J.Cell.2018.03.036 |
0.799 |
|
| 2018 |
Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Vitamin E-based glycoside amphiphiles for membrane protein structural studies. Organic & Biomolecular Chemistry. PMID 29564464 DOI: 10.1039/C8Ob00270C |
0.744 |
|
| 2018 |
Zhang Y, Hong S, Ruangprasert A, Skiniotis G, Dunham CM. Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel. Structure (London, England : 1993). PMID 29456023 DOI: 10.1016/J.Str.2018.01.013 |
0.347 |
|
| 2018 |
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, ... Skiniotis G, et al. Structure of the mu-opioid receptor-Giprotein complex. Nature. 558: 547-552. DOI: 10.2210/Pdb6Dde/Pdb |
0.801 |
|
| 2018 |
Larsen K, Mathiharan Y, Kappel K, Coey A, Chen D, Madigan L, Skiniotis G, Puglisi J, Viani Puglisi E. Structural Characterization of the HIV-1 Reverse Transcriptase Initiation Complex Biophysical Journal. 114: 193a. DOI: 10.1016/J.Bpj.2017.11.1080 |
0.777 |
|
| 2017 |
Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study. Chemical Science. 8: 8315-8324. PMID 29619178 DOI: 10.1039/C7Sc03700G |
0.745 |
|
| 2017 |
Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/J.Cell.2017.11.014 |
0.424 |
|
| 2017 |
Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/j.cell.2017.11.014 |
0.309 |
|
| 2017 |
Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, Zimmerman E, Bashan A, Isobe T, Jaffe CL, Yonath A, Skiniotis G. Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nature Communications. 8: 1589. PMID 29150609 DOI: 10.2210/Pdb6Az1/Pdb |
0.787 |
|
| 2017 |
Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. The Analyst. PMID 28913526 DOI: 10.1039/C7An01168G |
0.698 |
|
| 2017 |
Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B, Adams EJ. Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28807997 DOI: 10.1073/Pnas.1707547114 |
0.359 |
|
| 2017 |
Gao Y, Westfield G, Erickson JW, Cerione RA, Skiniotis G, Ramachandran S. Isolation and Structure-function Characterization of a Signaling-active Rhodopsin-G protein Complex. The Journal of Biological Chemistry. PMID 28655769 DOI: 10.1074/Jbc.M117.797100 |
0.833 |
|
| 2017 |
Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G. Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature. PMID 28538729 DOI: 10.1038/Nature22394 |
0.843 |
|
| 2017 |
Su M, Guo EZ, Ding X, Li Y, Tarrasch JT, Brooks CL, Xu Z, Skiniotis G. Mechanism of Vps4 hexamer function revealed by cryo-EM. Science Advances. 3: e1700325. PMID 28439563 DOI: 10.1126/Sciadv.1700325 |
0.411 |
|
| 2017 |
Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, ... ... Skiniotis G, et al. Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature. PMID 28437792 DOI: 10.1038/Nature22327 |
0.524 |
|
| 2017 |
Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell. 169: 407-421.e16. PMID 28431242 DOI: 10.1016/J.Cell.2017.03.047 |
0.511 |
|
| 2017 |
Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, ... ... Skiniotis G, et al. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223524 DOI: 10.1073/Pnas.1701529114 |
0.475 |
|
| 2017 |
Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. Journal of the American Chemical Society. PMID 28218862 DOI: 10.1021/Jacs.6B11997 |
0.344 |
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| 2017 |
De M, Oleskie AN, Ayyash M, Dutta S, Mancour L, Abazeed ME, Brace EJ, Skiniotis G, Fuller RS. The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion. The Journal of Cell Biology. PMID 28122955 DOI: 10.1083/Jcb.201606078 |
0.793 |
|
| 2016 |
Cheng S, Seven AB, Wang J, Skiniotis G, Özkan E. Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex. Structure (London, England : 1993). 24: 2163-2173. PMID 27926833 DOI: 10.1016/J.Str.2016.11.004 |
0.769 |
|
| 2016 |
Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. PMID 27499021 DOI: 10.1016/J.Cell.2016.07.004 |
0.472 |
|
| 2016 |
Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN. Flexible, symmetry-directed approach to assembling protein cages. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432965 DOI: 10.1073/Pnas.1606013113 |
0.396 |
|
| 2016 |
Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G. 2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania. Cell Reports. PMID 27373148 DOI: 10.1016/J.Celrep.2016.06.014 |
0.793 |
|
| 2016 |
Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. Journal of the American Chemical Society. PMID 26966956 DOI: 10.1021/Jacs.5B13233 |
0.372 |
|
| 2016 |
Drake EJ, Miller BR, Shi C, Tarrasch JT, Sundlov JA, Allen CL, Skiniotis G, Aldrich CC, Gulick AM. Structures of two distinct conformations of holo-non-ribosomal peptide synthetases. Nature. 529: 235-8. PMID 26762461 DOI: 10.1038/Nature16163 |
0.39 |
|
| 2015 |
Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. Plos Pathogens. 11: e1005322. PMID 26646856 DOI: 10.1371/Journal.Ppat.1005322 |
0.645 |
|
| 2015 |
Skiniotis G, Southworth DR. Single-particle cryo-electron microscopy of macromolecular complexes. Microscopy (Oxford, England). PMID 26611544 DOI: 10.1093/Jmicro/Dfv366 |
0.315 |
|
| 2015 |
Verma V, Mallik L, Hariadi RF, Sivaramakrishnan S, Skiniotis G, Joglekar AP. Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds. Plos One. 10: e0137125. PMID 26348722 DOI: 10.1371/Journal.Pone.0137125 |
0.314 |
|
| 2015 |
Peisley A, Skiniotis G. 2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy. Methods in Molecular Biology (Clifton, N.J.). 1335: 29-38. PMID 26260592 DOI: 10.1007/978-1-4939-2914-6_3 |
0.362 |
|
| 2015 |
Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B. The ERdj5 reductase cooperates with PDI to promote SV40 ER membrane translocation. Journal of Virology. PMID 26085143 DOI: 10.1128/Jvi.00941-15 |
0.775 |
|
| 2015 |
Yee A, Oleskie AN, Dosey AM, Kretz CA, Gildersleeve RD, Dutta S, Su M, Ginsburg D, Skiniotis G. Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII. Blood. PMID 26065653 DOI: 10.1182/Blood-2015-04-641696 |
0.779 |
|
| 2015 |
Smith JL, Skiniotis G, Sherman DH. Architecture of the polyketide synthase module: surprises from electron cryo-microscopy. Current Opinion in Structural Biology. 31: 9-19. PMID 25791608 DOI: 10.1016/J.Sbi.2015.02.014 |
0.349 |
|
| 2015 |
Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Genes & Development. 29: 123-8. PMID 25593305 DOI: 10.1101/Gad.254870.114 |
0.432 |
|
| 2014 |
Tremblay V, Zhang P, Chaturvedi CP, Thornton J, Brunzelle JS, Skiniotis G, Shilatifard A, Brand M, Couture JF. Molecular basis for DPY-30 association to COMPASS-like and NURF complexes. Structure (London, England : 1993). 22: 1821-30. PMID 25456412 DOI: 10.1016/J.Str.2014.10.002 |
0.408 |
|
| 2014 |
Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Skiniotis G, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/Nature13430 |
0.837 |
|
| 2014 |
Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510: 560-4. PMID 24965656 DOI: 10.1038/Nature13409 |
0.68 |
|
| 2014 |
Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Structure of a modular polyketide synthase. Nature. 510: 512-7. PMID 24965652 DOI: 10.1038/Nature13423 |
0.662 |
|
| 2014 |
Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL. Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science (New York, N.Y.). 343: 881-5. PMID 24505133 DOI: 10.1126/Science.1247749 |
0.667 |
|
| 2014 |
Vashisth H, Skiniotis G, Brooks CL. Collective variable approaches for single molecule flexible fitting and enhanced sampling. Chemical Reviews. 114: 3353-65. PMID 24446720 DOI: 10.1021/Cr4005988 |
0.342 |
|
| 2014 |
Thornton JL, Westfield GH, Takahashi YH, Cook M, Gao X, Woodfin AR, Lee JS, Morgan MA, Jackson J, Smith ER, Couture JF, Skiniotis G, Shilatifard A. Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation. Genes & Development. 28: 115-20. PMID 24402317 DOI: 10.1101/Gad.232215.113 |
0.767 |
|
| 2014 |
Patterson DP, Su M, Franzmann TM, Sciore A, Skiniotis G, Marsh EN. Characterization of a highly flexible self-assembling protein system designed to form nanocages. Protein Science : a Publication of the Protein Society. 23: 190-9. PMID 24318954 DOI: 10.1002/Pro.2405 |
0.351 |
|
| 2013 |
Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K. Inhibition of AMPK catabolic action by GSK3. Molecular Cell. 50: 407-19. PMID 23623684 DOI: 10.1016/J.Molcel.2013.03.022 |
0.302 |
|
| 2013 |
Vashisth H, Skiniotis G, Brooks CL. Enhanced sampling and overfitting analyses in structural refinement of nucleic acids into electron microscopy maps. The Journal of Physical Chemistry. B. 117: 3738-46. PMID 23506287 DOI: 10.1021/Jp3126297 |
0.35 |
|
| 2013 |
Couture JF, Skiniotis G. Assembling a COMPASS. Epigenetics : Official Journal of the Dna Methylation Society. 8: 349-54. PMID 23470558 DOI: 10.4161/Epi.24177 |
0.332 |
|
| 2013 |
Cline EN, Li MH, Choi SK, Herbstman JF, Kaul N, Meyhöfer E, Skiniotis G, Baker JR, Larson RG, Walter NG. Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action. Biomacromolecules. 14: 654-64. PMID 23391096 DOI: 10.1021/Bm301719B |
0.783 |
|
| 2013 |
Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ. Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain. Nature Structural & Molecular Biology. 20: 355-62. PMID 23377541 DOI: 10.1038/Nsmb.2497 |
0.701 |
|
| 2013 |
Sherman D, Skiniotis G, Smith J, Håkansson K, Dutta S, Whicher J, Hansen D, Hale W, Chemler J, Congdon G, Narayan A. The Structure and Rearrangements of a Complete Polyketide Synthase Module During its Catalytic Cycle Planta Medica. 79. DOI: 10.1055/S-0033-1348499 |
0.641 |
|
| 2012 |
Soppina V, Herbstman JF, Skiniotis G, Verhey KJ. Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules. Plos One. 7: e48204. PMID 23110214 DOI: 10.1371/Journal.Pone.0048204 |
0.785 |
|
| 2012 |
Mancour LV, Daghestani HN, Dutta S, Westfield GH, Schilling J, Oleskie AN, Herbstman JF, Chou SZ, Skiniotis G. Ligand-induced architecture of the leptin receptor signaling complex. Molecular Cell. 48: 655-61. PMID 23063524 DOI: 10.1016/J.Molcel.2012.09.003 |
0.769 |
|
| 2012 |
Vashisth H, Skiniotis G, Brooks CL. Using enhanced sampling and structural restraints to refine atomic structures into low-resolution electron microscopy maps. Structure (London, England : 1993). 20: 1453-62. PMID 22958641 DOI: 10.1016/J.Str.2012.08.007 |
0.321 |
|
| 2012 |
Chan YP, Lu M, Dutta S, Yan L, Barr J, Flora M, Feng YR, Xu K, Nikolov DB, Wang LF, Skiniotis G, Broder CC. Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins. Journal of Virology. 86: 11457-71. PMID 22915804 DOI: 10.1128/Jvi.01318-12 |
0.663 |
|
| 2012 |
Thompson AD, Bernard SM, Skiniotis G, Gestwicki JE. Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress & Chaperones. 17: 313-27. PMID 22076723 DOI: 10.1007/S12192-011-0307-1 |
0.396 |
|
| 2012 |
Yee A, Oleskie AN, Gildersleeve RD, Kretz CA, Su M, McGee BM, Carr KM, Skiniotis G, Ginsburg D. Partial in Vivo FVIII Stabilization by VWF Fragments Blood. 120: 15-15. DOI: 10.1182/Blood.V120.21.15.15 |
0.775 |
|
| 2012 |
Cline E, Li M, Ki Choi S, Herbstman J, Kaul N, Meyhofer E, Skiniotis G, Baker JR, Larson RG, Walter NG. Taxol-Conjugated Pamam Dendrimers Utilize Three Modes of Action on Microtubule Structure Biophysical Journal. 102: 187a. DOI: 10.1016/J.Bpj.2011.11.1022 |
0.788 |
|
| 2011 |
Takahashi YH, Westfield GH, Oleskie AN, Trievel RC, Shilatifard A, Skiniotis G. Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human. Proceedings of the National Academy of Sciences of the United States of America. 108: 20526-31. PMID 22158900 DOI: 10.1073/Pnas.1109360108 |
0.792 |
|
| 2011 |
Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, ... ... Skiniotis G, et al. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 16086-91. PMID 21914848 DOI: 10.1073/Pnas.1113645108 |
0.82 |
|
| 2011 |
Strunk BS, Loucks CR, Su M, Vashisth H, Cheng S, Schilling J, Brooks CL, Karbstein K, Skiniotis G. Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates. Science (New York, N.Y.). 333: 1449-53. PMID 21835981 DOI: 10.1126/Science.1208245 |
0.783 |
|
| 2011 |
Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, ... ... Skiniotis G, et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature. 477: 549-55. PMID 21772288 DOI: 10.1038/Nature10361 |
0.523 |
|
| 2011 |
Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH. Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angewandte Chemie (International Ed. in English). 50: 2795-8. PMID 21387490 DOI: 10.1002/Anie.201005280 |
0.614 |
|
| 2011 |
Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, Garcia KC. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (London, England : 1993). 19: 45-55. PMID 21220115 DOI: 10.1016/J.Str.2010.10.010 |
0.58 |
|
| 2010 |
Mancour L, Schilling J, Skiniotis G. Structural Characterization of the Activated Leptin Receptor Complex Microscopy and Microanalysis. 16: 1064-1065. DOI: 10.1017/S1431927610061404 |
0.809 |
|
| 2008 |
Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Molecular Cell. 31: 737-48. PMID 18775332 DOI: 10.1016/J.Molcel.2008.08.011 |
0.6 |
|
| 2007 |
Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D. Structural basis of Dscam isoform specificity. Nature. 449: 487-91. PMID 17721508 DOI: 10.1038/Nature06147 |
0.564 |
|
| 2007 |
Skiniotis G, Moazed D, Walz T. Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex. The Journal of Biological Chemistry. 282: 20804-8. PMID 17535815 DOI: 10.1074/Jbc.C700081200 |
0.538 |
|
| 2007 |
Ruch C, Skiniotis G, Steinmetz MO, Walz T, Ballmer-Hofer K. Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nature Structural & Molecular Biology. 14: 249-50. PMID 17293873 DOI: 10.1038/Nsmb1202 |
0.621 |
|
| 2005 |
Skiniotis G, Boulanger MJ, Garcia KC, Walz T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nature Structural & Molecular Biology. 12: 545-51. PMID 15895091 DOI: 10.1038/Nsmb941 |
0.598 |
|
| 2004 |
Santarella RA, Skiniotis G, Goldie KN, Tittmann P, Gross H, Mandelkow EM, Mandelkow E, Hoenger A. Surface-decoration of microtubules by human tau. Journal of Molecular Biology. 339: 539-53. PMID 15147841 DOI: 10.1016/J.Jmb.2004.04.008 |
0.615 |
|
| 2004 |
Skiniotis G, Cochran JC, Müller J, Mandelkow E, Gilbert SP, Hoenger A. Modulation of kinesin binding by the C-termini of tubulin. The Embo Journal. 23: 989-99. PMID 14976555 DOI: 10.1038/Sj.Emboj.7600118 |
0.624 |
|
| 2003 |
Skiniotis G, Surrey T, Altmann S, Gross H, Song YH, Mandelkow E, Hoenger A. Nucleotide-induced conformations in the neck region of dimeric kinesin. The Embo Journal. 22: 1518-28. PMID 12660159 DOI: 10.1093/Emboj/Cdg164 |
0.63 |
|
| 2003 |
Wendt T, Skiniotis G, Hoenger A. Cryo-electron microscopy and 3-D image analysis of microtubules complexed with molecular motors Microscopy and Microanalysis. 9: 398-399. DOI: 10.1017/S1431927603033063 |
0.589 |
|
| 2002 |
Wendt TG, Volkmann N, Skiniotis G, Goldie KN, Müller J, Mandelkow E, Hoenger A. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd. The Embo Journal. 21: 5969-78. PMID 12426369 DOI: 10.1093/Emboj/Cdf622 |
0.626 |
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