Gaynor A Smith - Publications

Affiliations: 
Cardiff University, Cardiff, Wales, United Kingdom 
Area:
Drosophila, Parkinson's disease, Huntington's disease, mitochondria

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Maddison DC, Malik B, Amadio L, Bis-Brewer DM, Züchner S, Peters OM, Smith GA. COPI-regulated mitochondria-ER contact site formation maintains axonal integrity. Cell Reports. 42: 112883. PMID 37498742 DOI: 10.1016/j.celrep.2023.112883  0.742
2022 Rees D, Beynon AL, Lelos MJ, Smith GA, Roberts LD, Phelps L, Dunnett SB, Morgan AH, Brown RM, Wells T, Davies JS. Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson's Disease. Cellular and Molecular Neurobiology. PMID 36107359 DOI: 10.1007/s10571-022-01282-9  0.531
2021 Peters OM, Smith GA. A nod and a Wnk to axon branching and destruction. Neuron. 109: 2799-2802. PMID 34534451 DOI: 10.1016/j.neuron.2021.08.027  0.747
2021 Lin TH, Bis-Brewer DM, Sheehan AE, Townsend LN, Maddison DC, Züchner S, Smith GA, Freeman MR. TSG101 negatively regulates mitochondrial biogenesis in axons. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33972422 DOI: 10.1073/pnas.2018770118  0.515
2021 Peters OM, Weiss A, Metterville J, Song L, Logan R, Smith GA, Schwarzschild MA, Mueller C, Brown RH, Freeman M. Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of Disease. 105368. PMID 33892050 DOI: 10.1016/j.nbd.2021.105368  0.765
2020 Precious SV, Smith GA, Heuer A, Jaeger I, Lane EL, Dunnett SB, Li M, Kelly CM, Rosser AE. Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson's Disease Model. Frontiers in Neuroscience. 14: 312. PMID 32317925 DOI: 10.3389/Fnins.2020.00312  0.774
2019 Malik BR, Maddison DC, Smith GA, Peters OM. Autophagic and endo-lysosomal dysfunction in neurodegenerative disease. Molecular Brain. 12: 100. PMID 31783880 DOI: 10.1186/S13041-019-0504-X  0.756
2019 Smith GA, Lin TH, Sheehan AE, Van der Goes van Naters W, Neukomm LJ, Graves HK, Bis-Brewer DM, Züchner S, Freeman MR. Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation. Neuron. PMID 31101394 DOI: 10.1016/J.Neuron.2019.04.017  0.584
2016 Breger LS, Kienle K, Smith GA, Dunnett SB, Lane EL. Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity. PMID 27864045 DOI: 10.1016/J.Bbi.2016.11.014  0.764
2015 Smith GA, Jansson J, Rocha EM, Osborn T, Hallett PJ, Isacson O. Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Molecular Neurobiology. PMID 26399642 DOI: 10.1007/S12035-015-9435-4  0.543
2015 Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease. PMID 26392287 DOI: 10.1016/J.Nbd.2015.09.009  0.583
2015 Lewis EA, Smith GA. Using Drosophila models of Huntington's disease as a translatable tool. Journal of Neuroscience Methods. PMID 26241927 DOI: 10.1016/J.Jneumeth.2015.07.026  0.36
2015 Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Chronic pharmacological glucocerebrosidase inhibition induces α-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice. Antioxidants & Redox Signaling. PMID 26094487 DOI: 10.1089/Ars.2015.6307  0.56
2015 Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson O. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology. 2: 433-8. PMID 25909088 DOI: 10.1002/Acn3.177  0.543
2015 Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O. A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). Plos One. 10: e0121072. PMID 25815475 DOI: 10.1371/Journal.Pone.0121072  0.602
2015 Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 16: 269-74. PMID 25732245 DOI: 10.1016/J.Stem.2015.01.018  0.624
2014 McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson O. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology. 261: 217-29. PMID 24907400 DOI: 10.1016/J.Expneurol.2014.05.024  0.508
2014 McLean JR, Smith GA, Rocha EM, Hayes MA, Beagan JA, Hallett PJ, Isacson O. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576: 73-8. PMID 24882721 DOI: 10.1016/J.Neulet.2014.05.044  0.534
2014 Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics. 23: 4510-27. PMID 24728190 DOI: 10.1093/Hmg/Ddu166  0.575
2014 Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK. Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of Disease. 64: 79-87. PMID 24388974 DOI: 10.1016/J.Nbd.2013.12.011  0.607
2013 Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells (Dayton, Ohio). 31: 1548-62. PMID 23666606 DOI: 10.1002/Stem.1415  0.59
2013 Peters OM, Shelkovnikova T, Tarasova T, Springe S, Kukharsky MS, Smith GA, Brooks S, Kozin SA, Kotelevtsev Y, Bachurin SO, Ninkina N, Buchman VL. Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease : Jad. 36: 589-96. PMID 23645096 DOI: 10.3233/Jad-130071  0.735
2013 Heuer A, Smith GA, Dunnett SB. Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice. The European Journal of Neuroscience. 37: 294-302. PMID 23113688 DOI: 10.1111/Ejn.12036  0.67
2012 Smith GA, Heuer A, Klein A, Vinh NN, Dunnett SB, Lane EL. Amphetamine-induced dyskinesia in the transplanted hemi-Parkinsonian mouse. Journal of Parkinson's Disease. 2: 107-13. PMID 23933747 DOI: 10.3233/Jpd-2012-12102  0.776
2012 Smith GA, Isacson O, Dunnett SB. The search for genetic mouse models of prodromal Parkinson's disease. Experimental Neurology. 237: 267-73. PMID 22819262 DOI: 10.1016/J.Expneurol.2012.06.035  0.663
2012 Smith GA, Breger LS, Lane EL, Dunnett SB. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology. 63: 818-28. PMID 22722025 DOI: 10.1016/J.Neuropharm.2012.06.011  0.771
2012 Smith GA, Dunnett SB, Lane EL. Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat--response to pharmacological modulation. Behavioural Brain Research. 232: 411-5. PMID 22516841 DOI: 10.1016/J.Bbr.2012.04.003  0.726
2012 Heuer A, Smith GA, Lelos MJ, Lane EL, Dunnett SB. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research. 228: 30-43. PMID 22146593 DOI: 10.1016/J.Bbr.2011.11.027  0.773
2012 Smith GA, Heuer A, Dunnett SB, Lane EL. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia. Behavioural Brain Research. 226: 281-92. PMID 21946310 DOI: 10.1016/J.Bbr.2011.09.025  0.767
2011 Torres EM, Lane EL, Heuer A, Smith GA, Murphy E, Dunnett SB. Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates. Journal of Neuroscience Methods. 200: 29-35. PMID 21723319 DOI: 10.1016/J.Jneumeth.2011.06.012  0.753
2011 Lane EL, Daly CS, Smith GA, Dunnett SB. Context-driven changes in L-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiology of Disease. 42: 99-107. PMID 21220017 DOI: 10.1016/J.Nbd.2011.01.010  0.712
2011 Smith GA, Heuer A. 6-OHDA toxin model in mouse Neuromethods. 61: 281-297. DOI: 10.1007/978-1-61779-298-4_14  0.565
2010 Lane EL, Smith GA. Understanding graft-induced dyskinesia. Regenerative Medicine. 5: 787-97. PMID 20868333 DOI: 10.2217/Rme.10.42  0.685
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