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Ku-Lung Hsu - Publications

Affiliations: 
Chemistry University of Virginia, Charlottesville, VA 
 2023- University of Texas at Austin, Austin, Texas, U.S.A. 
Website:
https://hsulab.com/index.html
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mendez R, Shaikh M, Lemke MC, Yuan K, Libby AH, Bai DL, Ross MM, Harris TE, Hsu KL. Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold. Rsc Chemical Biology. 4: 422-430. PMID 37292058 DOI: 10.1039/d3cb00057e  0.319
2023 Ciancone AM, Seo KW, Chen M, Borne AL, Libby AH, Bai DL, Kleiner RE, Hsu KL. Global Discovery of Covalent Modulators of Ribonucleoprotein Granules. Journal of the American Chemical Society. PMID 37159397 DOI: 10.1021/jacs.3c00165  0.801
2022 Ciancone AM, Hosseinibarkooie S, Bai DL, Borne AL, Ferris HA, Hsu KL. Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chemical Biology. 29: 1709-1720.e7. PMID 36476517 DOI: 10.1016/j.chembiol.2022.11.008  0.785
2022 Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, ... Hsu KL, et al. ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer. Developmental Cell. PMID 35508175 DOI: 10.1016/j.devcel.2022.04.014  0.776
2021 McCloud RL, Yuan K, Mahoney KE, Bai DL, Shabanowitz J, Ross MM, Hunt DF, Hsu KL. Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Analytical Chemistry. PMID 34431655 DOI: 10.1021/acs.analchem.1c01591  0.312
2021 Hussain SS, Tran TM, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu KL, Kashatus DF. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal. Cell Reports. 36: 109451. PMID 34320341 DOI: 10.1016/j.celrep.2021.109451  0.789
2021 Ware TB, Hsu KL. Advances in chemical proteomic evaluation of lipid kinases-DAG kinases as a case study. Current Opinion in Chemical Biology. 65: 101-108. PMID 34311404 DOI: 10.1016/j.cbpa.2021.06.007  0.802
2021 Huang T, Hosseinibarkooie S, Borne AL, Granade ME, Brulet JW, Harris TE, Ferris HA, Hsu KL. Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chemical Science. 12: 3295-3307. PMID 34164099 DOI: 10.1039/d0sc06623k  0.831
2021 Borne AL, Brulet JW, Yuan K, Hsu KL. Development and biological applications of sulfur-triazole exchange (SuTEx) chemistry. Rsc Chemical Biology. 2: 322-337. PMID 34095850 DOI: 10.1039/d0cb00180e  0.805
2021 Nass SR, Steele FF, Ware TB, Libby AH, Hsu KL, Kinsey SG. Monoacylglycerol Lipase Inhibition Using JZL184 Attenuates Paw Inflammation and Functional Deficits in a Mouse Model of Inflammatory Arthritis. Cannabis and Cannabinoid Research. PMID 34042520 DOI: 10.1089/can.2020.0177  0.774
2021 Toroitich EK, Ciancone AM, Hahm HS, Brodowski SM, Libby AH, Hsu KL. Discovery of a cell-active SuTEx ligand of prostaglandin reductase 2. Chembiochem : a European Journal of Chemical Biology. PMID 33861519 DOI: 10.1002/cbic.202000879  0.786
2020 Brulet JW, Borne AL, Yuan K, Libby AH, Hsu KL. Liganding Functional Tyrosine Sites on Proteins Using Sulfur-Triazole Exchange Chemistry. Journal of the American Chemical Society. PMID 32329615 DOI: 10.1021/Jacs.0C00648  0.812
2020 Shin M, Ware TB, Hsu KL. DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages. Cell Chemical Biology. PMID 31991095 DOI: 10.1016/J.Chembiol.2020.01.005  0.779
2020 Ware TB, Franks CE, Granade ME, Zhang M, Kim KB, Park KS, Gahlmann A, Harris TE, Hsu KL. Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering. Nature Chemical Biology. PMID 31932721 DOI: 10.1038/S41589-019-0445-9  0.789
2019 Yin B, Mendez R, Zhao XY, Rakhit R, Hsu KL, Ewald SE. Automated Spatially Targeted Optical Micro Proteomics (autoSTOMP) to Determine Protein Complexity of Subcellular Structures. Analytical Chemistry. PMID 31869197 DOI: 10.1021/Acs.Analchem.9B04396  0.341
2019 Hahm HS, Toroitich EK, Borne AL, Brulet JW, Libby AH, Yuan K, Ware TB, McCloud RL, Ciancone AM, Hsu KL. Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nature Chemical Biology. PMID 31768034 DOI: 10.1038/S41589-019-0404-5  0.757
2019 Ware TB, Shin M, Hsu KL. Metabolomics analysis of lipid metabolizing enzyme activity. Methods in Enzymology. 626: 407-428. PMID 31606084 DOI: 10.1016/Bs.Mie.2019.06.027  0.785
2019 Lazo JS, Blanco IK, Tasker NR, Rastelli EJ, Burnett JC, Garrott SR, Hart DJ, McCloud RL, Hsu KL, Wipf P, Sharlow ER. Next-Generation Cell-active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase. The Journal of Pharmacology and Experimental Therapeutics. PMID 31601683 DOI: 10.1124/Jpet.119.262188  0.418
2019 Franks CE, Hsu KL. Activity-Based Kinome Profiling Using Chemical Proteomics and ATP Acyl Phosphates. Current Protocols in Chemical Biology. 11: e72. PMID 31483100 DOI: 10.1002/Cpch.72  0.811
2019 Shin M, Buckner A, Prince J, Bullock TNJ, Hsu KL. Diacylglycerol Lipase-β Is Required for TNF-α Response but Not CD8 T Cell Priming Capacity of Dendritic Cells. Cell Chemical Biology. PMID 31105063 DOI: 10.1016/J.Chembiol.2019.04.002  0.791
2019 Shin M, Ware TB, Lee HC, Hsu KL. Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 1864: 907-921. PMID 30905349 DOI: 10.1016/J.Bbalip.2018.08.007  0.781
2018 Manterola A, Bernal-Chico A, Cipriani R, Ruiz A, Pérez-Samartín A, Moreno-Rodríguez M, Hsu KL, Cravatt B, Brown JM, Rodríguez-Puertas R, Matute C, Mato S. Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis. Neuropharmacology. PMID 30171986 DOI: 10.1016/J.Neuropharm.2018.08.038  0.514
2018 Campbell ST, Franks CE, Borne AL, Shin M, Zhang L, Hsu KL. Chemoproteomic discovery of a ritanserin-targeted kinase network mediating apoptotic cell death of lung tumor cells. Molecular Pharmacology. PMID 30158316 DOI: 10.1124/Mol.118.113001  0.777
2018 Borne AL, Huang T, McCloud RL, Pachaiyappan B, Bullock TNJ, Hsu KL. Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling. Current Topics in Microbiology and Immunology. PMID 30128827 DOI: 10.1007/82_2018_124  0.781
2018 Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-García Á, Martín-Fontecha M, Pérez-Cerdá F, Victoria Sánchez-Gómez M, Ortega-Gutiérrez S, Mark Brown J, Hsu KL, Cravatt B, Matute C, Mato S. Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination. Biochemical Pharmacology. PMID 30075103 DOI: 10.1016/J.Bcp.2018.07.042  0.498
2018 Shin M, Franks CE, Hsu KL. Isoform-selective activity-based profiling of ERK signaling. Chemical Science. 9: 2419-2431. PMID 29732117 DOI: 10.1039/C8Sc00043C  0.805
2018 Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, Mustafa MA, Poklis J, Niphakis M, Hsu KL, Cravatt BF, Gewirtz DA, Damaj MI, Lichtman AH. Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 29540562 DOI: 10.1124/Jpet.117.245704  0.485
2018 Wilkerson JL, Curry ZA, Kinlow PD, Mason BL, Hsu KL, van der Stelt M, Cravatt BF, Lichtman AH. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain. PMID 29528965 DOI: 10.1097/J.Pain.0000000000001199  0.367
2017 McCloud RL, Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL. Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics. Biochemistry. PMID 29155586 DOI: 10.1021/Acs.Biochem.7B00962  0.831
2017 Shin M, Snyder HW, Donvito G, Schurman LD, Fox TE, Lichtman AH, Kester M, Hsu KL. Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo. Molecular Pharmaceutics. PMID 28901776 DOI: 10.1021/Acs.Molpharmaceut.7B00657  0.793
2017 Franks CE, Campbell ST, Purow BW, Harris TE, Hsu KL. The Ligand Binding Landscape of Diacylglycerol Kinases. Cell Chemical Biology. PMID 28712745 DOI: 10.1016/J.Chembiol.2017.06.007  0.817
2017 Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochemical and Biophysical Research Communications. PMID 28684316 DOI: 10.1016/J.Bbrc.2017.06.195  0.476
2016 Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI, Cravatt BF, Lichtman AH. Diacylglycerol lipase beta inhibition reverses nociceptive behavior in mouse models of inflammatory and neuropathic pain. British Journal of Pharmacology. PMID 26915789 DOI: 10.1111/Bph.13469  0.356
2016 Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Parsons LH. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. Proceedings of the National Academy of Sciences of the United States of America. PMID 26755579 DOI: 10.1073/pnas.1522672113  0.602
2015 Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allarà M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, et al. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society. 137: 8851-7. PMID 26083464 DOI: 10.1021/Jacs.5B04883  0.578
2015 Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK. Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. Acs Chemical Biology. 10: 1624-30. PMID 25945974 DOI: 10.1021/Acschembio.5B00053  0.734
2015 Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, ... ... Hsu KL, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32. PMID 25602368 DOI: 10.1021/Cb500893Q  0.79
2014 Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, Marnett LJ. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. The Journal of Biological Chemistry. 289: 33741-53. PMID 25301951 DOI: 10.1074/Jbc.M114.582353  0.6
2014 Inloes JM, Hsu KL, Dix MM, Viader A, Masuda K, Takei T, Wood MR, Cravatt BF. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proceedings of the National Academy of Sciences of the United States of America. 111: 14924-9. PMID 25267624 DOI: 10.1073/Pnas.1413706111  0.694
2014 Grim TW, Ghosh S, Hsu KL, Cravatt BF, Kinsey SG, Lichtman AH. Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models. Pharmacology, Biochemistry, and Behavior. 124: 405-11. PMID 25058512 DOI: 10.1016/J.Pbb.2014.07.008  0.451
2014 Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 83: 361-71. PMID 25033180 DOI: 10.1016/J.Neuron.2014.06.030  0.344
2014 Agrawal P, Kurcon T, Pilobello KT, Rakus JF, Koppolu S, Liu Z, Batista BS, Eng WS, Hsu KL, Liang Y, Mahal LK. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proceedings of the National Academy of Sciences of the United States of America. 111: 4338-43. PMID 24591635 DOI: 10.1073/Pnas.1321524111  0.761
2014 Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nature Chemical Biology. 10: 113-21. PMID 24362705 DOI: 10.1038/Nchembio.1429  0.742
2014 Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. The Journal of Biological Chemistry. 289: 1491-504. PMID 24297180 DOI: 10.1074/Jbc.M113.497651  0.391
2013 Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry. 56: 8270-9. PMID 24152295 DOI: 10.1021/Jm400899C  0.809
2013 Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Journal of Medicinal Chemistry. 56: 8257-69. PMID 24152245 DOI: 10.1021/Jm400898X  0.794
2013 Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43. PMID 23260346 DOI: 10.1016/J.Bmcl.2012.11.061  0.768
2012 Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nature Chemical Biology. 8: 999-1007. PMID 23103940 DOI: 10.1038/Nchembio.1105  0.555
2012 Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8. PMID 22690931 DOI: 10.1021/Ja303400U  0.811
2012 Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF. Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. Journal of the American Chemical Society. 134: 5068-71. PMID 22400490 DOI: 10.1021/Ja300799T  0.535
2012 Adibekian A, Martin BR, Wang C, Hsu K, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Erratum: Corrigendum: Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors Nature Chemical Biology. 8: 318-318. DOI: 10.1038/Nchembio0312-318C  0.679
2011 Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nature Chemical Biology. 7: 469-78. PMID 21572424 DOI: 10.1038/Nchembio.579  0.709
2011 Propheter DC, Hsu KL, Mahal LK. Recombinant lectin microarrays for glycomic analysis. Methods in Molecular Biology (Clifton, N.J.). 723: 67-77. PMID 21370060 DOI: 10.1007/978-1-61779-043-0_6  0.594
2011 Hsu KL, Pilobello K, Krishnamoorthy L, Mahal LK. Ratiometric lectin microarray analysis of the mammalian cell surface glycome. Methods in Molecular Biology (Clifton, N.J.). 671: 117-31. PMID 20967626 DOI: 10.1007/978-1-59745-551-0_6  0.775
2010 Propheter DC, Hsu KL, Mahal LK. Fabrication of an oriented lectin microarray. Chembiochem : a European Journal of Chemical Biology. 11: 1203-7. PMID 20486145 DOI: 10.1002/Cbic.201000106  0.507
2009 Hsu KL, Mahal LK. Sweet tasting chips: microarray-based analysis of glycans. Current Opinion in Chemical Biology. 13: 427-32. PMID 19716334 DOI: 10.1016/J.Cbpa.2009.07.013  0.599
2008 Hsu KL, Gildersleeve JC, Mahal LK. A simple strategy for the creation of a recombinant lectin microarray. Molecular Biosystems. 4: 654-62. PMID 18493664 DOI: 10.1039/B800725J  0.6
2006 Hsu KL, Mahal LK. A lectin microarray approach for the rapid analysis of bacterial glycans. Nature Protocols. 1: 543-9. PMID 17406280 DOI: 10.1038/Nprot.2006.76  0.574
2006 Hsu KL, Pilobello KT, Mahal LK. Analyzing the dynamic bacterial glycome with a lectin microarray approach. Nature Chemical Biology. 2: 153-7. PMID 16462751 DOI: 10.1038/Nchembio767  0.565
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