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Ryan E. Hibbs, Ph.D. - Publications

Affiliations: 
Neurscience University of Texas Southwestern Medical Center, Dallas, TX, United States 
Area:
Ligand-gated ion channel structural biology
Website:
https://www.utsouthwestern.edu/labs/hibbs/
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE. Structural insights into opposing actions of neurosteroids on GABA receptors. Nature Communications. 14: 5091. PMID 37607940 DOI: 10.1038/s41467-023-40800-1  0.835
2023 Goswami U, Rahman MM, Teng J, Hibbs RE. Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nature Communications. 14: 3169. PMID 37264005 DOI: 10.1038/s41467-023-38827-5  0.8
2023 Allard CAH, Kang G, Kim JJ, Valencia-Montoya WA, Hibbs RE, Bellono NW. Structural basis of sensory receptor evolution in octopus. Nature. 616: 373-377. PMID 37045920 DOI: 10.1038/s41586-023-05822-1  0.858
2023 Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE. Sensory specializations drive octopus and squid behaviour. Nature. 616: 378-383. PMID 37045917 DOI: 10.1038/s41586-023-05808-z  0.833
2022 Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208081119. PMID 36251999 DOI: 10.1073/pnas.2208081119  0.803
2022 Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE. Structural and dynamic mechanisms of GABA receptor modulators with opposing activities. Nature Communications. 13: 4582. PMID 35933426 DOI: 10.1038/s41467-022-32212-4  0.825
2022 Noviello CM, Kreye J, Teng J, Prüss H, Hibbs RE. Structural mechanisms of GABA receptor autoimmune encephalitis. Cell. 185: 2469-2477.e13. PMID 35803245 DOI: 10.1016/j.cell.2022.06.025  0.812
2022 Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE. Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nature Structural & Molecular Biology. PMID 35301478 DOI: 10.1038/s41594-022-00737-3  0.794
2021 Rahman MM, Worrell BT, Stowell MHB, Hibbs RE. Purification of a native nicotinic receptor. Methods in Enzymology. 653: 189-206. PMID 34099171 DOI: 10.1016/bs.mie.2020.12.003  0.587
2021 Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE. Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell. PMID 33735609 DOI: 10.1016/j.cell.2021.02.049  0.851
2021 Kim JJ, Hibbs RE. Direct Structural Insights into GABA Receptor Pharmacology. Trends in Biochemical Sciences. PMID 33674151 DOI: 10.1016/j.tibs.2021.01.011  0.634
2020 Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. PMID 32879488 DOI: 10.1038/S41586-020-2654-5  0.806
2020 Rahman MM, Teng J, Worrell BT, Noviello CM, Lee M, Karlin A, Stowell MHB, Hibbs RE. Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron. PMID 32275860 DOI: 10.1016/J.Neuron.2020.03.012  0.859
2020 Gharpure A, Noviello CM, Hibbs RE. Progress in nicotinic receptor structural biology. Neuropharmacology. 171: 108086. PMID 32272141 DOI: 10.1016/J.Neuropharm.2020.108086  0.861
2020 Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C. Modulation of the ligand-gated ion channel (ELIC) and the 5-HT receptor via a common vestibule site. Elife. 9. PMID 31990273 DOI: 10.7554/Elife.51511  0.8
2020 Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C. Author response: Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site Elife. DOI: 10.7554/Elife.51511.Sa2  0.801
2020 Zhuang Y, Gharpure A, Hibbs RE, Howard RJ, Lindahl ER. Molecular Dynamics Simulation of Ligand Binding and Ion Permeation in a Ganglionic Nicotinic Receptor Biophysical Journal. 118: 584a. DOI: 10.1016/J.Bpj.2019.11.3165  0.831
2020 Kim JJ, Gharpure A, Teng J, Zhu S, Noviello CM, Walsh RM, Hibbs RE. Cryo-EM Structure of the α1β2γ2 GabaAReceptor in a Lipidic Environment Biophysical Journal. 118: 582a-583a. DOI: 10.1016/J.Bpj.2019.11.3160  0.738
2019 Mann N, Kause F, Henze EK, Gharpure A, Shril S, Connaughton DM, Nakayama M, Klämbt V, Majmundar AJ, Wu CW, Kolvenbach CM, Dai R, Chen J, van der Ven AT, Ityel H, ... ... Hibbs RE, et al. CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations. American Journal of Human Genetics. PMID 31708116 DOI: 10.1016/J.Ajhg.2019.10.004  0.787
2019 Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor. Neuron. PMID 31488329 DOI: 10.1016/J.Bpj.2019.11.3177  0.847
2019 Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL. Heteromeric neuronal nicotinic acetylcholine receptors with mutant beta subunits acquire sensitivity to α7-selective positive allosteric modulators. The Journal of Pharmacology and Experimental Therapeutics. PMID 31175218 DOI: 10.1124/Jpet.119.259499  0.792
2019 Kim JJ, Hibbs RE. Bridges between Antimalarials and Synaptic Transmission. Neuron. 101: 546-547. PMID 30790532 DOI: 10.1016/J.Neuron.2019.01.057  0.584
2019 Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor Neuron. 104: 501-511. DOI: 10.2210/Pdb6Pv8/Pdb  0.819
2018 Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE. Structure of a human synaptic GABA receptor. Nature. PMID 29950725 DOI: 10.1038/S41586-018-0255-3  0.808
2018 Walsh RM, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE. Structural principles of distinct assemblies of the human α4β2 nicotinic receptor. Nature. PMID 29720657 DOI: 10.1038/S41586-018-0081-7  0.829
2018 Hibbs R, Dutzler R. Decision letter: Cryo-EM structure of the mechanically activated ion channel OSCA1.2 Elife. DOI: 10.7554/Elife.41845.036  0.337
2018 Jr RWW, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE. Structural principles underlying distinct assemblies of the human alpha4beta2 nicotinic receptor Nature. DOI: 10.2210/Pdb6Cnk/Pdb  0.853
2018 Walsh RM, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE. Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor. Nature. 557: 261-265. DOI: 10.2210/Pdb6Cnj/Pdb  0.828
2018 Walsh RM, Roh S, Hibbs RE. Resolution of Heterogeneity in Nicotinic Receptor Assembly by Cryo-EM Biophysical Journal. 114: 10a-11a. DOI: 10.1016/J.Bpj.2017.11.097  0.774
2017 Morales-Perez CL, Noviello CM, Hibbs RE. Structure and Mechanism of Neuronal Nicotinic Acetylcholine Receptors Biophysical Journal. 112: 320a. DOI: 10.1016/J.Bpj.2016.11.1735  0.863
2016 Morales-Perez CL, Noviello CM, Hibbs RE. X-ray structure of the human α4β2 nicotinic receptor. Nature. PMID 27698419 DOI: 10.1038/Nature19785  0.864
2016 Morales-Perez CL, Noviello CM, Hibbs RE. Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins. Structure (London, England : 1993). PMID 27041595 DOI: 10.1016/J.Str.2016.03.004  0.788
2016 Morales-Perez CL, Noviello CM, Hibbs RE. X-ray structure of the human alpha 4 beta 2 nicotinic receptor. Nature. 538: 411-415. DOI: 10.2210/Pdb5Kxi/Pdb  0.79
2014 Althoff T, Hibbs RE, Banerjee S, Gouaux E. X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature. 512: 333-7. PMID 25143115 DOI: 10.1038/Nature13669  0.545
2012 Hattori M, Hibbs RE, Gouaux E. A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. Structure (London, England : 1993). 20: 1293-9. PMID 22884106 DOI: 10.1016/J.Str.2012.06.009  0.318
2011 Hibbs RE, Gouaux E. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature. 474: 54-60. PMID 21572436 DOI: 10.1038/Nature10139  0.59
2009 Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. The Embo Journal. 28: 3040-51. PMID 19696737 DOI: 10.1038/Emboj.2009.227  0.828
2008 Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P. Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proceedings of the National Academy of Sciences of the United States of America. 105: 7606-11. PMID 18477694 DOI: 10.1073/Pnas.0802197105  0.828
2007 Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE, Shi J. Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes. Biochemical Pharmacology. 74: 1164-71. PMID 17826748 DOI: 10.1016/J.Bcp.2007.07.038  0.869
2006 Hibbs RE, Johnson DA, Shi J, Taylor P. Structural dynamics of the acetylcholine binding protein: hydrodynamic and fluorescence anisotropy decay analyses. Journal of Molecular Neuroscience : Mn. 30: 73-4. PMID 17192634 DOI: 10.1385/Jmn:30:1:73  0.662
2006 Hibbs RE, Radic Z, Taylor P, Johnson DA. Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein. The Journal of Biological Chemistry. 281: 39708-18. PMID 17068341 DOI: 10.1074/Jbc.M604752200  0.622
2005 Hibbs RE, Johnson DA, Shi J, Hansen SB, Taylor P. Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: hydrodynamic and fluorescence anisotropy decay analyses. Biochemistry. 44: 16602-11. PMID 16342951 DOI: 10.1021/Bi051735P  0.683
2004 Hibbs RE, Talley TT, Taylor P. Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein. The Journal of Biological Chemistry. 279: 28483-91. PMID 15117947 DOI: 10.1074/Jbc.M403713200  0.766
2004 Taylor P, Hansen SB, Talley TT, Hibbs RE, Radi? Z. Contemporary paradigms for cholinergic ligand design guided by biological structure. Bioorganic & Medicinal Chemistry Letters. 14: 1875-7. PMID 15050619 DOI: 10.1016/J.Bmcl.2003.10.072  0.859
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