| Year |
Citation |
Score |
| 2020 |
Liu J, Han J, Izawa K, Sato T, White S, Meanwell NA, Soloshonok VA. Cyclic tailor-made amino acids in the design of modern pharmaceuticals. European Journal of Medicinal Chemistry. 208: 112736. PMID 32966895 DOI: 10.1016/J.Ejmech.2020.112736 |
0.321 |
|
| 2020 |
Sivaprakasam P, Wang Z, Meanwell NA, Khan JA, Langley DR, Johnson SR, Li G, Pendri A, Connolly TP, Gao M, Camac DM, Klakouski C, Zvyaga T, Cianci C, McAuliffe B, et al. Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. 127531. PMID 32890685 DOI: 10.1016/J.Bmcl.2020.127531 |
0.372 |
|
| 2020 |
Patel M, Cianci C, Allard CW, Parker DD, Simmermacher J, Jenkins S, Mcauliffe B, Minassian B, Discotto L, Krystal M, Meanwell NA, Naidu BN. Design, Synthesis and SAR Study of Novel C2-Pyrazolopyrimidine Amides and Amide Isosteres as Allosteric Integrase Inhibitors. Bioorganic & Medicinal Chemistry Letters. 127516. PMID 32860982 DOI: 10.1016/J.Bmcl.2020.127516 |
0.411 |
|
| 2020 |
Patel M, Naidu BN, Dicker I, Higley H, Lin Z, Terry B, Protack T, Krystal M, Jenkins S, Parker D, Panja C, Rampulla R, Mathur A, Meanwell NA, Walker MA. Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 115541. PMID 32389483 DOI: 10.1016/J.Bmc.2020.115541 |
0.377 |
|
| 2020 |
Mei H, Han J, White S, Graham DJ, Izawa K, Sato T, Fustero S, Meanwell NA, Soloshonok VA. Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in the Modern Pharmaceuticals. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32359086 DOI: 10.1002/Chem.202000617 |
0.308 |
|
| 2020 |
Li G, Meanwell NA, Krystal MR, Langley DR, Naidu BN, Sivaprakasam P, Lewis H, Kish K, Khan JA, Ng A, Trainor GL, Cianci C, Dicker IB, Walker MA, Lin Z, et al. Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry. PMID 32081010 DOI: 10.1021/Acs.Jmedchem.9B01681 |
0.361 |
|
| 2020 |
Oderinde MS, Mao E, Ramirez A, Pawluczyk J, Jorge C, Cornelius LAM, Kempson J, Vetrichelvan M, Pitchai M, Gupta A, Gupta AK, Meanwell NA, Mathur A, Dhar TGM. Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity. Journal of the American Chemical Society. PMID 31927959 DOI: 10.1021/Jacs.9B12129 |
0.311 |
|
| 2020 |
Karmakar A, Ramalingam S, Basha M, Indasi GK, Belema M, Meanwell NA, Dhar TGM, Rampulla R, Mathur A, Gupta A, Gupta AK. Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles Synthesis. 52: 441-449. DOI: 10.1055/S-0039-1690699 |
0.325 |
|
| 2020 |
Smith D, Krishnananthan S, Meanwell NA, Mathur A, Li J. Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process Organic Process Research & Development. 24: 1157-1163. DOI: 10.1021/Acs.Oprd.0C00198 |
0.346 |
|
| 2019 |
Peese KM, Narasimhulu Naidu B, Patel M, Li C, Langley DR, Terry B, Protack T, Gali V, Lin Z, Samanta HK, Zheng M, Jenkins S, Dicker IB, Krystal MR, Meanwell NA, et al. Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors. Bioorganic & Medicinal Chemistry Letters. 126784. PMID 31761656 DOI: 10.1016/J.Bmcl.2019.126784 |
0.372 |
|
| 2019 |
Mei H, Han J, Klika KD, Izawa K, Sato T, Meanwell NA, Soloshonok VA. Applications of fluorine-containing amino acids for drug design. European Journal of Medicinal Chemistry. 111826. PMID 31740056 DOI: 10.1016/J.Ejmech.2019.111826 |
0.314 |
|
| 2019 |
Wang T, Wallace OB, Zhang Z, Fang H, Yang Z, Robinson BA, Spicer TP, Gong YF, Blair WS, Shi PY, Lin PF, Deshpande M, Meanwell NA, Kadow JF. A survey of core replacements in indole-based HIV-1 attachment inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30940396 DOI: 10.1016/J.Bmcl.2019.03.018 |
0.418 |
|
| 2019 |
A M Subbaiah M, Mandlekar S, Desikan S, Ramar T, Subramani L, Annadurai M, Desai SD, Sinha S, Jenkins SM, Krystal MR, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, ... ... Meanwell NA, et al. Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir. Journal of Medicinal Chemistry. PMID 30938524 DOI: 10.1021/Acs.Jmedchem.9B00002 |
0.345 |
|
| 2019 |
Regueiro-Ren A, Dicker IB, Hanumegowda U, Meanwell NA. Second Generation Inhibitors of HIV-1 Maturation. Acs Medicinal Chemistry Letters. 10: 287-294. PMID 30891128 DOI: 10.1021/Acsmedchemlett.8B00656 |
0.369 |
|
| 2019 |
Peese K, Allard C, Connolly T, Johnson B, Li C, Patel M, Sorensen M, Walker M, Meanwell NA, McAuliffe B, Minassian B, Krystal M, Parker D, Lewis HA, Kish K, et al. 5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent Allosteric Site HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry. PMID 30609350 DOI: 10.1021/Acs.Jmedchem.8B01473 |
0.357 |
|
| 2018 |
Wu YJ, Venables B, Guernon J, Chen J, Sit SY, Rajamani R, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Thompson LA, Dzierba C. Discovery of new indole-based acylsulfonamide Na1.7 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30638874 DOI: 10.1016/J.Bmcl.2018.12.013 |
0.373 |
|
| 2018 |
Yeung KS, Beno BR, Mosure K, Zhu J, Grant-Young KA, Parcella K, Anjanappa P, Bora RO, Selvakumar K, Wang YK, Fang H, Krause R, Rigat K, Liu M, Lemm J, ... ... Meanwell NA, et al. Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. Acs Medicinal Chemistry Letters. 9: 1217-1222. PMID 30613329 DOI: 10.1021/Acsmedchemlett.8B00379 |
0.383 |
|
| 2018 |
Luo G, Chen L, Easton A, Newton A, Bourin C, Shields E, Mosure K, Soars MG, Knox RJ, Matchett M, Pieschl RL, Post-Munson D, Wang S, Herrington J, Graef J, ... ... Meanwell NA, et al. Discovery of Indole- and Indazole-Acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 30576602 DOI: 10.1021/Acs.Jmedchem.8B01550 |
0.307 |
|
| 2018 |
Wang T, Ueda Y, Zhang Z, Yin Z, Matiskella J, Pearce BC, Yang Z, Zheng M, Parker D, Yamanaka G, Gong YF, Ho HT, Colonno R, Langley DR, Lin PF, ... Meanwell NA, et al. Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and its Phosphonooxymethyl Prodrug Fostemsavir. Journal of Medicinal Chemistry. PMID 29920093 DOI: 10.1021/Acs.Jmedchem.8B00759 |
0.377 |
|
| 2018 |
Naidu BN, Walker MA, Sorenson ME, Ueda Y, Matiskella JD, Connolly TP, Dicker IB, Lin Z, Bollini S, Terry BJ, Higley H, Zheng M, Parker DD, Wu D, Adams S, ... ... Meanwell NA, et al. The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor. Bioorganic & Medicinal Chemistry Letters. PMID 29779976 DOI: 10.1016/J.Bmcl.2018.05.027 |
0.385 |
|
| 2018 |
Subbaiah MAM, Meanwell NA, Kadow JF, Subramani L, Annadurai M, Ramar T, Desai SD, Sinha S, Subramanian M, Mandlekar S, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Jenkins SM, et al. Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir. Journal of Medicinal Chemistry. PMID 29693401 DOI: 10.1021/Acs.Jmedchem.8B00277 |
0.34 |
|
| 2018 |
Venables BL, Sin N, Wang AX, Sun LQ, Tu Y, Hernandez D, Sheaffer A, Lee M, Dunaj C, Zhai G, Barry D, Friborg J, Yu F, Knipe J, Sandquist J, ... ... Meanwell NA, et al. P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor. Bioorganic & Medicinal Chemistry Letters. PMID 29650290 DOI: 10.1016/J.Bmcl.2018.04.009 |
0.335 |
|
| 2018 |
Chen Y, Sit SY, Chen J, Swidorski JJ, Liu Z, Sin N, Venables BL, Parker DD, Nowicka-Sans B, Lin Z, Li Z, Terry BJ, Protack T, Rahematpura S, Hanumegowda U, ... ... Meanwell NA, et al. The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation. Bioorganic & Medicinal Chemistry Letters. PMID 29631960 DOI: 10.1016/J.Bmcl.2018.03.067 |
0.407 |
|
| 2018 |
Zheng B, D'Andrea SV, Sun LQ, Wang AX, Chen Y, Hrnciar P, Friborg J, Falk P, Hernandez D, Yu F, Sheaffer AK, Knipe JO, Mosure K, Rajamani R, Good AC, ... ... Meanwell NA, et al. Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor. Acs Medicinal Chemistry Letters. 9: 143-148. PMID 29456803 DOI: 10.1021/Acsmedchemlett.7B00503 |
0.368 |
|
| 2018 |
Wu YJ, Guernon J, McClure A, Venables B, Rajamani R, Robbins KJ, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Olson R, Thompson LA, Dzierba C. Discovery of morpholine-based aryl sulfonamides as Na1.7 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29439904 DOI: 10.1016/J.Bmcl.2018.01.035 |
0.357 |
|
| 2018 |
Meanwell NA. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design. Journal of Medicinal Chemistry. PMID 29400967 DOI: 10.1021/Acs.Jmedchem.7B01788 |
0.308 |
|
| 2018 |
Yeung K-, Beno BR, Mosure K, Zhu J, Grant-Young KA, Parcella K, Anjanappa P, Bora RO, Selvakumar K, Wang Y-, Fang H, Rigat K, Liu M, Lemm J, Sheriff S, ... ... Meanwell NA, et al. Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition of Hepatitis C Virus NS5B Replicase in Benzofuran Palm Site Allosteric Inhibitors Acs Medicinal Chemistry Letters. DOI: 10.2210/Pdb5Qj0/Pdb |
0.341 |
|
| 2017 |
Eastman KJ, Parcella K, Yeung KS, Grant-Young KA, Zhu J, Wang T, Zhang Z, Yin Z, Beno BR, Sheriff S, Kish K, Tredup J, Jardel AG, Halan V, Ghosh K, ... ... Meanwell NA, et al. The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. Medchemcomm. 8: 796-806. PMID 30108798 DOI: 10.1039/C6Md00636A |
0.335 |
|
| 2017 |
Meanwell NA, Krystal MR, Nowicka-Sans B, Langley DR, Conlon DA, Eastgate MD, Grasela DM, Timmins P, Wang T, Kadow JF. Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir. Journal of Medicinal Chemistry. PMID 29271653 DOI: 10.1021/Acs.Jmedchem.7B01337 |
0.37 |
|
| 2017 |
Zhuo X, Wang YZ, Yeung KS, Zhu J, Huang XS, Parcella KE, Eastman KJ, Kadow JF, Meanwell NA, Shu YZ, Johnson BM. Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-12. PMID 29182424 DOI: 10.1080/00498254.2017.1409915 |
0.385 |
|
| 2017 |
Bowsher M, Hiebert S, Li R, Wang AX, Friborg J, Yu F, Hernandez D, Wang YK, Klei H, Rajamani R, Mosure K, Knipe JO, Meanwell NA, McPhee F, Scola PM. The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease. Bioorganic & Medicinal Chemistry Letters. PMID 29162454 DOI: 10.1016/J.Bmcl.2017.11.005 |
0.35 |
|
| 2017 |
Mathur A, Wang B, Smith D, Li J, Pawluczyk J, Sun JH, Wong MK, Krishnananthan S, Wu DR, Sun D, Li P, Yip S, Cheng BC, Baran PS, Chen Q, ... ... Meanwell NA, et al. Development of large scale synthesis of tetrahydropyran glycine, a precursor to the HCV NS5A inhibitor BMS-986097. The Journal of Organic Chemistry. PMID 28877441 DOI: 10.1021/Acs.Joc.7B01852 |
0.365 |
|
| 2017 |
Subbaiah MAM, Meanwell NA, Kadow JF. Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties. European Journal of Medicinal Chemistry. 139: 865-883. PMID 28865281 DOI: 10.1016/J.Ejmech.2017.07.044 |
0.357 |
|
| 2017 |
Parcella K, Eastman K, Yeung KS, Grant-Young KA, Zhu J, Wang T, Zhang Z, Yin Z, Parker D, Mosure K, Fang H, Wang YK, Lemm J, Zhuo X, Hanumegowda U, ... ... Meanwell NA, et al. Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor. Acs Medicinal Chemistry Letters. 8: 771-774. PMID 28740615 DOI: 10.1021/Acsmedchemlett.7B00211 |
0.345 |
|
| 2017 |
Zheng BZ, D'Andrea SV, Hanumegowda U, Knipe JO, Mosure K, Zhuo X, Lemm JA, Liu M, Rigat KL, Wang YK, Fang H, Poronsky C, Cutrone J, Wu DR, Arunachalam PN, ... ... Meanwell NA, et al. Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters. PMID 28633899 DOI: 10.1016/J.Bmcl.2017.06.024 |
0.379 |
|
| 2017 |
Yeung KS, Beno BR, Parcella K, Bender JA, Grant-Young KA, Nickel A, Gunaga P, Anjanappa P, Bora RO, Selvakumar K, Rigat K, Wang YK, Liu M, Lemm JA, Mosure K, ... ... Meanwell NA, et al. Discovery of an HCV NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. Journal of Medicinal Chemistry. PMID 28430437 DOI: 10.1021/Acs.Jmedchem.7B00328 |
0.373 |
|
| 2017 |
Wu YJ, Guernon J, Shi J, Ditta J, Robbins KJ, Rajamani R, Easton A, Newton AE, Bourin C, Mosure K, Soars MG, Knox RJ, Matchett M, Pieschl RL, Post-Munson DJ, ... ... Meanwell NA, et al. Development of new benzenesulfonamides as potent and selective Nav1.7 inhibitors for the treatment of pain. Journal of Medicinal Chemistry. PMID 28234467 DOI: 10.1021/Acs.Jmedchem.6B01918 |
0.312 |
|
| 2016 |
Mull ES, Sun LQ, Zhao Q, Eggers B, Pokornowski K, Zhai G, Rajamani R, Jenkins S, Kramer M, Wang YK, Fang H, Tenney D, Baldick CJ, Cockett MI, Meanwell NA, et al. Functionalized triazines as potent HCV entry inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28089701 DOI: 10.1016/J.Bmcl.2016.12.038 |
0.386 |
|
| 2016 |
Wang AX, Chen J, Zhao Q, Sun LQ, Friborg J, Yu F, Hernandez D, Good AC, Klei HE, Rajamani R, Mosure K, Knipe JO, Li D, Zhu J, Levesque PC, ... ... Meanwell NA, et al. Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus. Bioorganic & Medicinal Chemistry Letters. PMID 28011221 DOI: 10.1016/J.Bmcl.2016.12.013 |
0.404 |
|
| 2016 |
Parcella K, Nickel A, Beno BR, Sheriff S, Wan C, Wang YK, Roberts SB, Meanwell NA, Kadow JF. Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorganic & Medicinal Chemistry Letters. PMID 27908764 DOI: 10.1016/J.Bmcl.2016.11.054 |
0.342 |
|
| 2016 |
Lin Z, Cantone J, Lu H, Nowicka-Sans B, Protack T, Yuan T, Yang H, Liu Z, Drexler D, Regueiro-Ren A, Meanwell NA, Cockett M, Krystal M, Lataillade M, Dicker IB. Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors. Plos Pathogens. 12: e1005990. PMID 27893830 DOI: 10.1371/Journal.Ppat.1005990 |
0.317 |
|
| 2016 |
Sun LQ, Mull E, Zheng B, D'Andrea S, Zhao Q, Wang AX, Sin N, Venables BL, Sit SY, Chen Y, Chen J, Cocuzza A, Bilder DM, Mathur A, Rampulla R, ... ... Meanwell NA, et al. Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing. Journal of Medicinal Chemistry. PMID 27564532 DOI: 10.1021/Acs.Jmedchem.6B00821 |
0.386 |
|
| 2016 |
Meanwell NA. 2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph. Journal of Medicinal Chemistry. 59: 7311-51. PMID 27501244 DOI: 10.1021/Acs.Jmedchem.6B00915 |
0.34 |
|
| 2016 |
Regueiro-Ren A, Liu Z, Chen Y, Sin N, Sit SY, Swidorski JJ, Chen J, Venables BL, Zhu J, Nowicka-Sans B, Protack T, Lin Z, Terry B, Samanta H, Zhang S, ... ... Meanwell NA, et al. Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity. Acs Medicinal Chemistry Letters. 7: 568-72. PMID 27326328 DOI: 10.1021/Acsmedchemlett.6B00010 |
0.329 |
|
| 2016 |
Nowicka-Sans B, Protack T, Lin Z, Li Z, Zhang S, Sun Y, Samanta H, Terry B, Liu Z, Chen Y, Sin N, Sit SY, Swidorski JJ, Chen J, Venables BL, ... ... Meanwell NA, et al. BMS-955176: Identification and Characterization of a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic Coverage. Antimicrobial Agents and Chemotherapy. PMID 27090171 DOI: 10.1128/Aac.02560-15 |
0.371 |
|
| 2016 |
Swidorski JJ, Liu Z, Sit SY, Chen J, Chen Y, Sin N, Venables BL, Parker DD, Nowicka-Sans B, Terry BJ, Protack T, Rahematpura S, Hanumegowda U, Jenkins S, Krystal M, ... ... Meanwell NA, et al. Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids. Bioorganic & Medicinal Chemistry Letters. PMID 26988305 DOI: 10.1016/J.Bmcl.2016.03.019 |
0.356 |
|
| 2016 |
Meanwell NA. Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space. Chemical Research in Toxicology. 29: 564-616. PMID 26974882 DOI: 10.1021/Acs.Chemrestox.6B00043 |
0.325 |
|
| 2016 |
Liu Z, Swidorski JJ, Nowicka-Sans B, Terry B, Protack T, Lin Z, Samanta H, Zhang S, Li Z, Parker DD, Rahematpura S, Jenkins S, Beno BR, Krystal M, Meanwell NA, et al. C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors. Bioorganic & Medicinal Chemistry. PMID 26968652 DOI: 10.1016/J.Bmc.2016.03.001 |
0.386 |
|
| 2015 |
Hewawasam P, Tu Y, Gao M, Hanumegowda U, Knipe J, Lemm JA, Parker DD, Rigat KL, Roberts SB, Meanwell NA, Kadow JF. Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase. Bioorganic & Medicinal Chemistry Letters. PMID 26747393 DOI: 10.1016/J.Bmcl.2015.12.058 |
0.362 |
|
| 2015 |
O'Boyle DR, Nower PT, Gao M, Fridell R, Wang C, Hewawasam P, Lopez O, Tu Y, Meanwell NA, Belema M, Roberts SB, Cockett M, Sun JH. Synergistic activity of combined NS5A inhibitors. Antimicrobial Agents and Chemotherapy. PMID 26711745 DOI: 10.1128/Aac.02639-15 |
0.34 |
|
| 2015 |
Swidorski JJ, Liu Z, Yin Z, Wang T, Carini DJ, Rahematpura S, Zheng M, Johnson K, Zhang S, Lin PF, Parker DD, Li W, Meanwell NA, Hamann LG, Regueiro-Ren A. Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore. Bioorganic & Medicinal Chemistry Letters. PMID 26584882 DOI: 10.1016/J.Bmcl.2015.11.009 |
0.376 |
|
| 2015 |
Sun JH, O'Boyle Ii DR, Fridell RA, Langley DR, Wang C, Roberts SB, Nower P, Johnson BM, Moulin F, Nophsker MJ, Wang YK, Liu M, Rigat K, Tu Y, Hewawasam P, ... ... Meanwell NA, et al. Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A. Nature. PMID 26536115 DOI: 10.1038/Nature15711 |
0.358 |
|
| 2015 |
Gillis EP, Eastman KJ, Hill MD, Donnelly DJ, Meanwell NA. Applications of Fluorine in Medicinal Chemistry. Journal of Medicinal Chemistry. 58: 8315-59. PMID 26200936 DOI: 10.1021/Acs.Jmedchem.5B00258 |
0.304 |
|
| 2015 |
Naidu BN, Sorenson ME, Patel M, Ueda Y, Banville J, Beaulieu F, Bollini S, Dicker IB, Higley H, Lin Z, Pajor L, Parker DD, Terry BJ, Zheng M, Martel A, ... Meanwell NA, et al. Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 717-20. PMID 25529736 DOI: 10.1016/J.Bmcl.2014.11.060 |
0.333 |
|
| 2014 |
Belema M, Meanwell NA. Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect. Journal of Medicinal Chemistry. 57: 5057-71. PMID 24749835 DOI: 10.1021/Jm500335H |
0.371 |
|
| 2014 |
Lemm JA, Liu M, Gentles RG, Ding M, Voss S, Pelosi LA, Wang YK, Rigat KL, Mosure KW, Bender JA, Knipe JO, Colonno R, Meanwell NA, Kadow JF, Santone KS, et al. Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 58: 3485-95. PMID 24733465 DOI: 10.1128/Aac.02495-13 |
0.352 |
|
| 2014 |
Timmins P, Brown J, Meanwell NA, Hanna GJ, Zhu L, Kadow JF. Enabled clinical use of an HIV-1 attachment inhibitor through drug delivery. Drug Discovery Today. 19: 1288-93. PMID 24727410 DOI: 10.1016/J.Drudis.2014.03.025 |
0.349 |
|
| 2014 |
Eastman KJ, Yang Z, Bender JA, Mosure K, Lemm JA, Meanwell NA, Roberts SB, Knipe J, Kadow JF. Identification of a novel series of potent HCV NS5B Site I inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 1993-7. PMID 24656612 DOI: 10.1016/J.Bmcl.2014.02.047 |
0.361 |
|
| 2014 |
Lambert SM, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, Matthews SJ. The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors. Protein Science : a Publication of the Protein Society. 23: 723-34. PMID 24639329 DOI: 10.1002/Pro.2456 |
0.312 |
|
| 2014 |
Belema M, Lopez OD, Bender JA, Romine JL, St Laurent DR, Langley DR, Lemm JA, O'Boyle DR, Sun JH, Wang C, Fridell RA, Meanwell NA. Discovery and development of hepatitis C virus NS5A replication complex inhibitors. Journal of Medicinal Chemistry. 57: 1643-72. PMID 24621191 DOI: 10.1021/Jm401793M |
0.354 |
|
| 2014 |
Scola PM, Sun LQ, Wang AX, Chen J, Sin N, Venables BL, Sit SY, Chen Y, Cocuzza A, Bilder DM, D'Andrea SV, Zheng B, Hewawasam P, Tu Y, Friborg J, ... ... Meanwell NA, et al. The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. Journal of Medicinal Chemistry. 57: 1730-52. PMID 24564672 DOI: 10.1021/Jm500297K |
0.37 |
|
| 2014 |
Scola PM, Wang AX, Good AC, Sun LQ, Combrink KD, Campbell JA, Chen J, Tu Y, Sin N, Venables BL, Sit SY, Chen Y, Cocuzza A, Bilder DM, D'Andrea S, ... ... Meanwell NA, et al. Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection. Journal of Medicinal Chemistry. 57: 1708-29. PMID 24555570 DOI: 10.1021/Jm401840S |
0.418 |
|
| 2014 |
Belema M, Nguyen VN, Bachand C, Deon DH, Goodrich JT, James CA, Lavoie R, Lopez OD, Martel A, Romine JL, Ruediger EH, Snyder LB, St Laurent DR, Yang F, Zhu J, ... ... Meanwell NA, et al. Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir. Journal of Medicinal Chemistry. 57: 2013-32. PMID 24521299 DOI: 10.1021/Jm401836P |
0.402 |
|
| 2014 |
Belema M, Nguyen VN, Romine JL, St Laurent DR, Lopez OD, Goodrich JT, Nower PT, O'Boyle DR, Lemm JA, Fridell RA, Gao M, Fang H, Krause RG, Wang YK, Oliver AJ, ... ... Meanwell NA, et al. Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons. Journal of Medicinal Chemistry. 57: 1995-2012. PMID 24437689 DOI: 10.1021/Jm4016203 |
0.37 |
|
| 2014 |
Gentles RG, Ding M, Bender JA, Bergstrom CP, Grant-Young K, Hewawasam P, Hudyma T, Martin S, Nickel A, Regueiro-Ren A, Tu Y, Yang Z, Yeung KS, Zheng X, Chao S, ... ... Meanwell NA, et al. Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase. Journal of Medicinal Chemistry. 57: 1855-79. PMID 24397558 DOI: 10.1021/Jm4016894 |
0.423 |
|
| 2014 |
St Laurent DR, Serrano-Wu MH, Belema M, Ding M, Fang H, Gao M, Goodrich JT, Krause RG, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle DR, Pearce BC, ... ... Meanwell NA, et al. HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity. Journal of Medicinal Chemistry. 57: 1976-94. PMID 23573957 DOI: 10.1021/Jm301796K |
0.319 |
|
| 2014 |
Hewawasam P, Tu Y, Hudyma TW, Zhang X, Gentles RG, Kadow JF, Meanwell NA. A practical and efficient synthesis of 6-carboalkoxy-13-cycloalkyl-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid derivatives Tetrahedron Letters. 55: 1148-1153. DOI: 10.1016/J.Tetlet.2013.12.085 |
0.337 |
|
| 2013 |
O'Boyle DR, Sun JH, Nower PT, Lemm JA, Fridell RA, Wang C, Romine JL, Belema M, Nguyen VN, St. Laurent DR, Serrano-Wu M, Snyder LB, Meanwell NA, Langley DR, Gao M. Characterizations of HCV NS5A replication complex inhibitors Virology. 444: 343-354. PMID 23896639 DOI: 10.1016/J.Virol.2013.06.032 |
0.373 |
|
| 2013 |
Belema M, Nguyen VN, St. Laurent DR, Lopez OD, Qiu Y, Good AC, Nower PT, Valera L, O'Boyle DR, Sun JH, Liu M, Fridell RA, Lemm JA, Gao M, Knipe JO, ... Meanwell NA, et al. HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives Bioorganic and Medicinal Chemistry Letters. 23: 4428-4435. PMID 23803586 DOI: 10.1016/J.Bmcl.2013.05.040 |
0.343 |
|
| 2013 |
Treitler DS, Li Z, Krystal M, Meanwell NA, Snyder SA. Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A. Bioorganic & Medicinal Chemistry Letters. 23: 2192-6. PMID 23434230 DOI: 10.1016/J.Bmcl.2013.01.098 |
0.355 |
|
| 2013 |
Regueiro-Ren A, Simmermacher-Mayer J, Sinz M, Johnson KA, Huang XS, Jenkins S, Parker D, Rahematpura S, Zheng M, Meanwell NA, Kadow JF. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248. Journal of Medicinal Chemistry. 56: 1670-6. PMID 23374053 DOI: 10.1021/Jm301638A |
0.36 |
|
| 2013 |
Regueiro-Ren A, Xue QM, Swidorski JJ, Gong YF, Mathew M, Parker DD, Yang Z, Eggers B, D'Arienzo C, Sun Y, Malinowski J, Gao Q, Wu D, Langley DR, Colonno RJ, ... ... Meanwell NA, et al. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248). Journal of Medicinal Chemistry. 56: 1656-69. PMID 23360431 DOI: 10.1021/Jm3016377 |
0.414 |
|
| 2013 |
Lopez OD, Nguyen VN, St. Laurent DR, Belema M, Serrano-Wu MH, Goodrich JT, Yang F, Qiu Y, Ripka AS, Nower PT, Valera L, Liu M, O'Boyle DR, Sun JH, Fridell RA, ... ... Meanwell NA, et al. HCV NS5A replication complex inhibitors. Part 3 Bioorganic and Medicinal Chemistry Letters. 23: 779-784. PMID 23273521 DOI: 10.1016/J.Bmcl.2012.11.086 |
0.332 |
|
| 2013 |
Bender JA, Yang Z, Eggers B, Gong YF, Lin PF, Parker DD, Rahematpura S, Zheng M, Meanwell NA, Kadow JF. Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores. Bioorganic & Medicinal Chemistry Letters. 23: 218-22. PMID 23206859 DOI: 10.1016/J.Bmcl.2012.10.118 |
0.368 |
|
| 2013 |
Wang T, Yang Z, Zhang Z, Gong YF, Riccardi KA, Lin PF, Parker DD, Rahematpura S, Mathew M, Zheng M, Meanwell NA, Kadow JF, Bender JA. Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores. Bioorganic & Medicinal Chemistry Letters. 23: 213-7. PMID 23200254 DOI: 10.1016/J.Bmcl.2012.10.120 |
0.391 |
|
| 2013 |
Yeung KS, Qiu Z, Xue Q, Fang H, Yang Z, Zadjura L, D'Arienzo CJ, Eggers BJ, Riccardi K, Shi PY, Gong YF, Browning MR, Gao Q, Hansel S, Santone K, ... ... Meanwell NA, et al. Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents. Bioorganic & Medicinal Chemistry Letters. 23: 198-202. PMID 23200252 DOI: 10.1016/J.Bmcl.2012.10.115 |
0.423 |
|
| 2013 |
Yeung KS, Qiu Z, Yin Z, Trehan A, Fang H, Pearce B, Yang Z, Zadjura L, D'Arienzo CJ, Riccardi K, Shi PY, Spicer TP, Gong YF, Browning MR, Hansel S, ... ... Meanwell NA, et al. Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 203-8. PMID 23200249 DOI: 10.1016/J.Bmcl.2012.10.117 |
0.392 |
|
| 2013 |
Yeung KS, Qiu Z, Yang Z, Zadjura L, D'Arienzo CJ, Browning MR, Hansel S, Huang XS, Eggers BJ, Riccardi K, Lin PF, Meanwell NA, Kadow JF. Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative. Bioorganic & Medicinal Chemistry Letters. 23: 209-12. PMID 23200244 DOI: 10.1016/J.Bmcl.2012.10.125 |
0.345 |
|
| 2012 |
St Laurent DR, Belema M, Gao M, Goodrich J, Kakarla R, Knipe JO, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle D, Qiu Y, Romine JL, Serrano-Wu MH, ... ... Meanwell NA, et al. HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides. Bioorganic & Medicinal Chemistry Letters. 22: 6063-6. PMID 22959243 DOI: 10.1016/J.Bmcl.2012.08.049 |
0.345 |
|
| 2012 |
McPhee F, Sheaffer AK, Friborg J, Hernandez D, Falk P, Zhai G, Levine S, Chaniewski S, Yu F, Barry D, Chen C, Lee MS, Mosure K, Sun LQ, Sinz M, ... Meanwell NA, et al. Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032). Antimicrobial Agents and Chemotherapy. 56: 5387-96. PMID 22869577 DOI: 10.1128/Aac.01186-12 |
0.362 |
|
| 2012 |
Nowicka-Sans B, Gong YF, McAuliffe B, Dicker I, Ho HT, Zhou N, Eggers B, Lin PF, Ray N, Wind-Rotolo M, Zhu L, Majumdar A, Stock D, Lataillade M, Hanna GJ, ... ... Meanwell NA, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrobial Agents and Chemotherapy. 56: 3498-507. PMID 22547625 DOI: 10.1128/Aac.00426-12 |
0.361 |
|
| 2012 |
Kadow JF, Ueda Y, Meanwell NA, Connolly TP, Wang T, Chen CP, Yeung KS, Zhu J, Bender JA, Yang Z, Parker D, Lin PF, Colonno RJ, Mathew M, Morgan D, et al. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 6. Preclinical and human pharmacokinetic profiling of BMS-663749, a phosphonooxymethyl prodrug of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043). Journal of Medicinal Chemistry. 55: 2048-56. PMID 22356441 DOI: 10.1021/Jm201218M |
0.368 |
|
| 2011 |
Romine JL, St Laurent DR, Leet JE, Martin SW, Serrano-Wu MH, Yang F, Gao M, O'Boyle DR, Lemm JA, Sun JH, Nower PT, Huang XS, Deshpande MS, Meanwell NA, Snyder LB. Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes. Acs Medicinal Chemistry Letters. 2: 224-9. PMID 24900306 DOI: 10.1021/Ml1002647 |
0.364 |
|
| 2011 |
Gish RG, Meanwell NA. The NS5A replication complex inhibitors: difference makers? Clinics in Liver Disease. 15: 627-39. PMID 21867941 DOI: 10.1016/J.Cld.2011.05.010 |
0.358 |
|
| 2011 |
Qiu D, Lemm JA, O'Boyle DR, Sun JH, Nower PT, Nguyen V, Hamann LG, Snyder LB, Deon DH, Ruediger E, Meanwell NA, Belema M, Gao M, Fridell RA. The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization. The Journal of General Virology. 92: 2502-11. PMID 21795470 DOI: 10.1099/Vir.0.034801-0 |
0.366 |
|
| 2011 |
Pendri A, Meanwell NA, Peese KM, Walker MA. New first and second generation inhibitors of human immunodeficiency virus-1 integrase. Expert Opinion On Therapeutic Patents. 21: 1173-89. PMID 21599420 DOI: 10.1517/13543776.2011.586631 |
0.359 |
|
| 2011 |
Lemm JA, Leet JE, O'Boyle DR, Romine JL, Huang XS, Schroeder DR, Alberts J, Cantone JL, Sun JH, Nower PT, Martin SW, Serrano-Wu MH, Meanwell NA, Snyder LB, Gao M. Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures. Antimicrobial Agents and Chemotherapy. 55: 3795-802. PMID 21576451 DOI: 10.1128/Aac.00146-11 |
0.405 |
|
| 2011 |
Meanwell NA, Belema M. Hepatitis C Virus—Progress Toward Inhibiting the Nonenzymatic Viral Proteins Annual Reports in Medicinal Chemistry. 46: 263-282. DOI: 10.1016/B978-0-12-386009-5.00011-4 |
0.354 |
|
| 2010 |
Baldick CJ, Wichroski MJ, Pendri A, Walsh AW, Fang J, Mazzucco CE, Pokornowski KA, Rose RE, Eggers BJ, Hsu M, Zhai W, Zhai G, Gerritz SW, Poss MA, Meanwell NA, et al. A novel small molecule inhibitor of hepatitis C virus entry. Plos Pathogens. 6: e1001086. PMID 20838466 DOI: 10.1371/Journal.Ppat.1001086 |
0.367 |
|
| 2010 |
Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR, Lemm JA, Wang C, Knipe JO, Chien C, Colonno RJ, ... ... Meanwell NA, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Nature. 465: 96-100. PMID 20410884 DOI: 10.1038/Nature08960 |
0.346 |
|
| 2010 |
Lemm JA, O'Boyle D, Liu M, Nower PT, Colonno R, Deshpande MS, Snyder LB, Martin SW, St Laurent DR, Serrano-Wu MH, Romine JL, Meanwell NA, Gao M. Identification of hepatitis C virus NS5A inhibitors. Journal of Virology. 84: 482-91. PMID 19812153 DOI: 10.1128/Jvi.01360-09 |
0.408 |
|
| 2010 |
Yang Z, Zadjura LM, Marino AM, D'Arienzo CJ, Malinowski J, Gesenberg C, Lin PF, Colonno RJ, Wang T, Kadow JF, Meanwell NA, Hansel SB. Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties. Journal of Pharmaceutical Sciences. 99: 2135-52. PMID 19780144 DOI: 10.1002/Jps.21948 |
0.346 |
|
| 2010 |
Banville J, Bouthillier G, Plamondon S, Remillard R, Meanwell NA, Martel A, Walker MA. (Z)-2,2-Dimethyl-5-carboxymethylene-1,3-dioxolan-4-one: a new synthon for the synthesis of α,γ-diketoacid derivatives Tetrahedron Letters. 51: 3170-3173. DOI: 10.1016/J.Tetlet.2010.04.032 |
0.329 |
|
| 2010 |
Wang T, Kadow JF, Zhang Z, Yin Z, Gao Q, Wu D, Parker DD, Yang Z, Zadjura L, Robinson BA, Gong YF, Spicer TP, Blair WS, Shi PY, Yamanaka G, ... ... Meanwell NA, et al. Corrigendum to "Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives" [Bioorg. Med. Chem. Lett. 19 (2009) 5140] (DOI:10.1016/j.bmcl.2009.07.076) Bioorganic and Medicinal Chemistry Letters. 20: 1462. DOI: 10.1016/J.Bmcl.2010.01.022 |
0.368 |
|
| 2010 |
Meanwell NA, Wallace OB, Fang H, Wang H, Deshpande M, Wang T, Yin Z, Zhang Z, Pearce BC, James J, Yeung KS, Qiu Z, Wright JJK, Yang Z, Zadjura L, et al. Corrigendum to "Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns" [Bioorg. Med. Chem. Lett. 19 (2009) 1977] (DOI:10.1016/j.bmcl.2009.02.040) Bioorganic and Medicinal Chemistry Letters. 20: 1460. DOI: 10.1016/J.Bmcl.2010.01.020 |
0.326 |
|
| 2009 |
Wang T, Yin Z, Zhang Z, Bender JA, Yang Z, Johnson G, Yang Z, Zadjura LM, D'Arienzo CJ, DiGiugno Parker D, Gesenberg C, Yamanaka GA, Gong YF, Ho HT, Fang H, ... ... Meanwell NA, et al. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects. Journal of Medicinal Chemistry. 52: 7778-87. PMID 19769332 DOI: 10.1021/Jm900843G |
0.395 |
|
| 2009 |
Wang T, Kadow JF, Zhang Z, Yin Z, Gao Q, Wu D, Parker DD, Yang Z, Zadjura L, Robinson BA, Gong YF, Spicer TP, Blair WS, Shi PY, Yamanaka G, ... ... Meanwell NA, et al. Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives. Bioorganic & Medicinal Chemistry Letters. 19: 5140-5. PMID 19664921 DOI: 10.1016/J.Bmcl.2009.07.076 |
0.392 |
|
| 2009 |
Meanwell NA, Wallace OB, Wang H, Deshpande M, Pearce BC, Trehan A, Yeung KS, Qiu Z, Wright JJ, Robinson BA, Gong YF, Wang HG, Spicer TP, Blair WS, Shi PY, et al. Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity. Bioorganic & Medicinal Chemistry Letters. 19: 5136-9. PMID 19632112 DOI: 10.1016/J.Bmcl.2009.07.027 |
0.397 |
|
| 2009 |
Sin N, Venables BL, Combrink KD, Gulgeze HB, Yu KL, Civiello RL, Thuring J, Wang XA, Yang Z, Zadjura L, Marino A, Kadow KF, Cianci CW, Clarke J, Genovesi EV, ... ... Meanwell NA, et al. Respiratory syncytial virus fusion inhibitors. Part 7: Structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo Bioorganic and Medicinal Chemistry Letters. 19: 4857-4862. PMID 19596574 DOI: 10.1016/J.Bmcl.2009.06.030 |
0.395 |
|
| 2009 |
Meanwell NA, Wallace OB, Fang H, Wang H, Deshpande M, Wang T, Yin Z, Zhang Z, Pearce BC, James J, Yeung KS, Qiu Z, Kim Wright JJ, Yang Z, Zadjura L, et al. Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns. Bioorganic & Medicinal Chemistry Letters. 19: 1977-81. PMID 19251416 DOI: 10.1016/J.Bmcl.2009.02.040 |
0.375 |
|
| 2009 |
Meanwell NA, Kadow JF, Scola PM. Chapter 20 Progress towards the Discovery and Development of Specifically Targeted Inhibitors of Hepatitis C Virus Annual Reports in Medicinal Chemistry. 44: 397-440. DOI: 10.1016/S0065-7743(09)04420-0 |
0.355 |
|
| 2007 |
Combrink KD, Gulgeze HB, Thuring JW, Yu KL, Civiello RL, Zhang Y, Pearce BC, Yin Z, Langley DR, Kadow KF, Cianci CW, Li Z, Clarke J, Genovesi EV, Medina I, ... ... Meanwell NA, et al. Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety. Bioorganic & Medicinal Chemistry Letters. 17: 4784-90. PMID 17616396 DOI: 10.1016/J.Bmcl.2007.06.065 |
0.376 |
|
| 2007 |
Walker MA, Johnson T, Naidu BN, Banville J, Remillard R, Plamondon S, Martel A, Li C, Torri A, Samanta H, Lin Z, Dicker I, Krystal M, Meanwell NA. Benzyl amide-ketoacid inhibitors of HIV-integrase. Bioorganic & Medicinal Chemistry Letters. 17: 4886-90. PMID 17604626 DOI: 10.1016/J.Bmcl.2007.06.042 |
0.356 |
|
| 2007 |
Wang XA, Cianci CW, Yu KL, Combrink KD, Thuring JW, Zhang Y, Civiello RL, Kadow KF, Roach J, Li Z, Langley DR, Krystal M, Meanwell NA. Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity. Bioorganic & Medicinal Chemistry Letters. 17: 4592-8. PMID 17576060 DOI: 10.1016/J.Bmcl.2007.05.102 |
0.407 |
|
| 2007 |
Yu KL, Sin N, Civiello RL, Wang XA, Combrink KD, Gulgeze HB, Venables BL, Wright JJK, Dalterio RA, Zadjura L, Marino A, Dando S, D'Arienzo C, Kadow KF, Cianci CW, ... ... Meanwell NA, et al. Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability Bioorganic and Medicinal Chemistry Letters. 17: 895-901. PMID 17169560 DOI: 10.1016/J.Bmcl.2006.11.063 |
0.352 |
|
| 2007 |
Meanwell NA, Krystal M. Respiratory syncytial virus - The discovery and optimization of orally bioavailable fusion inhibitors Drugs of the Future. 32: 441. DOI: 10.1358/Dof.2007.032.05.1087141 |
0.316 |
|
| 2007 |
Yu KL, Sin N, Civiello RL, Wang XA, Combrink KD, Gulgeze HB, Venables BL, Kim Wright JJ, Dalterio RA, Zadjura L, Marino A, Dando S, D'Arienzo C, Kadow KF, Cianci CW, ... ... Meanwell NA, et al. Corrigendum to "Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability" [Bioorg. Med. Chem. Lett. 17 (2007) 895-901] (DOI:10.1016/j.bmcl.2006.11.063) Bioorganic and Medicinal Chemistry Letters. 17: 2385. DOI: 10.1016/J.Bmcl.2007.03.020 |
0.307 |
|
| 2006 |
Walker MA, Johnson T, Ma Z, Zhang Y, Banville J, Remillard R, Plamondon S, Pendri A, Wong H, Smith D, Torri A, Samanta H, Lin Z, Deminie C, Terry B, ... ... Meanwell N, et al. Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype. Bioorganic & Medicinal Chemistry Letters. 16: 5818-21. PMID 16971121 DOI: 10.1016/J.Bmcl.2006.08.075 |
0.367 |
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| 2006 |
Walker MA, Johnson T, Ma Z, Banville J, Remillard R, Kim O, Zhang Y, Staab A, Wong H, Torri A, Samanta H, Lin Z, Deminie C, Terry B, Krystal M, ... Meanwell N, et al. Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore. Bioorganic & Medicinal Chemistry Letters. 16: 2920-4. PMID 16546383 DOI: 10.1016/J.Bmcl.2006.03.010 |
0.342 |
|
| 2006 |
Yu KL, Wang XA, Civiello RL, Trehan AK, Pearce BC, Yin Z, Combrink KD, Gulgeze HB, Zhang Y, Kadow KF, Cianci CW, Clarke J, Genovesi EV, Medina I, Lamb L, ... ... Meanwell NA, et al. Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo. Bioorganic & Medicinal Chemistry Letters. 16: 1115-22. PMID 16368233 DOI: 10.1016/J.Bmcl.2005.11.109 |
0.372 |
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| 2006 |
Yang Z, Zadjura L, D'Arienzo C, Marino A, Santone K, Klunk L, Greene D, Lin PF, Colonno R, Wang T, Meanwell N, Hansel S. Preclinical pharmacokinetics of a novel HIV-1 attachment inhibitor BMS-378806 and prediction of its human pharmacokinetics. Biopharmaceutics & Drug Disposition. 26: 387-402. PMID 16142720 DOI: 10.1002/Bdd.471 |
0.318 |
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| 2006 |
Li J, Smith D, Wong HS, Campbell JA, Meanwell NA, Scola PM. A Facile Synthesis of 1-Substituted Cyclopropylsulfonamides Synlett. 2006: 725-728. DOI: 10.1055/S-2006-933130 |
0.31 |
|
| 2006 |
Zhu J, Wong H, Zhang Z, Yin Z, Meanwell NA, Kadow JF, Wang T. An effective procedure for the preparation of 3-substituted-4- or 6-azaindoles from ortho-methyl nitro pyridines Tetrahedron Letters. 47: 5653-5656. DOI: 10.1016/J.Tetlet.2006.06.017 |
0.305 |
|
| 2005 |
Cianci C, Meanwell N, Krystal M. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. Journal of Antimicrobial Chemotherapy. 55: 289-292. PMID 15681582 DOI: 10.1093/Jac/Dkh558 |
0.385 |
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| 2005 |
Yin Z, Zhang Z, Zhu J, Wong H, Kadow JF, Meanwell NA, Wang T. Synthesis of substituted aryl amidines from aminoacetonitriles Tetrahedron Letters. 46: 4919-4923. DOI: 10.1016/J.Tetlet.2005.04.142 |
0.315 |
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| 2005 |
Zhu J, Wong H, Zhang Z, Yin Z, Kadow JF, Meanwell NA, Wang T. A one-pot synthesis of nitrogen-containing heteroaryl α-keto amides from heteroaryl halides Tetrahedron Letters. 46: 3587-3589. DOI: 10.1016/J.Tetlet.2005.03.100 |
0.309 |
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| 2005 |
Yeung KS, Farkas ME, Kadow JF, Meanwell NA. A base-catalyzed, direct synthesis of 3,5-disubstituted 1,2,4-triazoles from nitriles and hydrazides Tetrahedron Letters. 46: 3429-3432. DOI: 10.1016/J.Tetlet.2005.02.167 |
0.311 |
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| 2004 |
Cianci C, Langley DR, Dischino DD, Sun Y, Yu K, Stanley A, Roach J, Li Z, Dalterio R, Colonno R, Meanwell NA, Krystal M. Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion Proceedings of the National Academy of Sciences of the United States of America. 101: 15046-15051. PMID 15469910 DOI: 10.1073/Pnas.0406696101 |
0.363 |
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| 2004 |
Cianci C, Genovesi EV, Lamb L, Medina I, Yang Z, Zadjura L, Yang H, D'Arienzo C, Sin N, Yu KL, Combrink K, Li Z, Colonno R, Meanwell N, Clark J, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrobial Agents and Chemotherapy. 48: 2448-54. PMID 15215093 DOI: 10.1128/Aac.48.7.2448-2454.2004 |
0.329 |
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| 2004 |
Yu KL, Zhang Y, Civiello RL, Trehan AK, Pearce BC, Yin Z, Combrink KD, Gulgeze HB, Wang XA, Kadow KF, Cianci CW, Krystal M, Meanwell NA. Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives. Bioorganic & Medicinal Chemistry Letters. 14: 1133-7. PMID 14980651 DOI: 10.1016/J.Bmcl.2003.12.072 |
0.376 |
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| 2004 |
Yin Z, Zhang Z, Kadow JF, Meanwell NA, Wang T. Acetonitrile derivatives as carbonyl synthons. One-pot preparation of diheteroaryl ketones via a strategy of sequential SNAr substitution and oxidation. The Journal of Organic Chemistry. 69: 1364-7. PMID 14961693 DOI: 10.1021/Jo030234B |
0.303 |
|
| 2004 |
Cianci C, Yu KL, Combrink K, Sin N, Pearce B, Wang A, Civiello R, Voss S, Luo G, Kadow K, Genovesi EV, Venables B, Gulgeze H, Trehan A, James J, ... ... Meanwell N, et al. Orally active fusion inhibitor of respiratory syncytial virus. Antimicrobial Agents and Chemotherapy. 48: 413-22. PMID 14742189 DOI: 10.1128/Aac.48.2.413-422.2004 |
0.344 |
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| 2004 |
Zhu J, Wong H, Zhang Z, Yin Z, Kadow JF, Meanwell NA, Wang T. Malononitrile as a carbonyl synthon: a one-pot preparation of heteroaryl amide via a SNAr-oxidation–displacement strategy ☆ Tetrahedron Letters. 45: 5909-5911. DOI: 10.1016/J.Tetlet.2004.05.154 |
0.33 |
|
| 2004 |
Ruediger E, Martel A, Meanwell N, Solomon C, Turmel B. Novel 3'-deoxy analogs of the anti-HBV agent entecavir: synthesis of enantiomers from a single chiral epoxide Tetrahedron Letters. 45: 739-742. DOI: 10.1016/J.Tetlet.2003.11.052 |
0.313 |
|
| 2003 |
Wang T, Zhang Z, Wallace OB, Deshpande M, Fang H, Yang Z, Zadjura LM, Tweedie DL, Huang S, Zhao F, Ranadive S, Robinson BS, Gong YF, Ricarrdi K, Spicer TP, ... ... Meanwell NA, et al. Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. Journal of Medicinal Chemistry. 46: 4236-9. PMID 13678401 DOI: 10.1021/Jm034082O |
0.331 |
|
| 2003 |
Guo Q, Ho HT, Dicker I, Fan L, Zhou N, Friborg J, Wang T, McAuliffe BV, Wang HG, Rose RE, Fang H, Scarnati HT, Langley DR, Meanwell NA, Abraham R, et al. Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions. Journal of Virology. 77: 10528-36. PMID 12970437 DOI: 10.1128/Jvi.77.19.10528-10536.2003 |
0.332 |
|
| 2003 |
Lin PF, Blair W, Wang T, Spicer T, Guo Q, Zhou N, Gong YF, Wang HG, Rose R, Yamanaka G, Robinson B, Li CB, Fridell R, Deminie C, Demers G, ... ... Meanwell N, et al. A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proceedings of the National Academy of Sciences of the United States of America. 100: 11013-8. PMID 12930892 DOI: 10.1073/Pnas.1832214100 |
0.35 |
|
| 2003 |
Yu KL, Zhang Y, Civiello RL, Kadow KF, Cianci C, Krystal M, Meanwell NA. Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor. Bioorganic & Medicinal Chemistry Letters. 13: 2141-2144. PMID 12798322 DOI: 10.1016/S0960-894X(03)00383-4 |
0.349 |
|
| 2003 |
McPhee F, Yeung KS, Good AC, Meanwell NA. Hepatitis C virus NS3 serine protease as a drug discovery target Drugs of the Future. 28: 465-488. DOI: 10.1358/Dof.2003.028.05.734774 |
0.373 |
|
| 2003 |
Meanwell NA, Serrano-Wu MH, Snyder LB. Chapter 22. Non-HIV antiviral agents Annual Reports in Medicinal Chemistry. 38: 213-228. DOI: 10.1016/S0065-7743(03)38023-6 |
0.375 |
|
| 2002 |
Yu KL, Torri AF, Luo G, Cianci C, Grant-Young K, Danetz S, Tiley L, Krystal M, Meanwell NA. Structure–activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-Trimethyl-5-hydroxy-cyclohexylmethylamine Bioorganic & Medicinal Chemistry Letters. 12: 3379-3382. PMID 12419365 DOI: 10.1016/S0960-894X(02)00761-8 |
0.347 |
|
| 2002 |
Sperandio D, Gangloff AR, Litvak J, Goldsmith R, Hataye JM, Wang VR, Shelton EJ, Elrod K, Janc JW, Clark JM, Rice K, Weinheimer S, Yeung KS, Meanwell NA, Hernandez D, et al. Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease. Bioorganic & Medicinal Chemistry Letters. 12: 3129-33. PMID 12372517 DOI: 10.1016/S0960-894X(02)00680-7 |
0.366 |
|
| 2002 |
Hewawasam P, Erway M, Moon SL, Knipe J, Weiner H, Boissard CG, Post-Munson DJ, Gao Q, Huang S, Gribkoff VK, Meanwell NA. Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties. Journal of Medicinal Chemistry. 45: 1487-99. PMID 11906290 DOI: 10.1021/Jm0101850 |
0.309 |
|
| 2002 |
Deshpande MS, Wei J, Luo G, Cianci C, Danetz S, Torri A, Tiley L, Krystal M, Yu KL, Huang S, Gao Q, Meanwell NA. An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology. Bioorganic & Medicinal Chemistry Letters. 11: 2393-6. PMID 11527739 DOI: 10.1016/S0960-894X(01)00459-0 |
0.377 |
|
| 2001 |
Yeung KS, Meanwell NA, Qiu Z, Hernandez D, Zhang S, McPhee F, Weinheimer S, Clark JM, Janc JW. Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease. Bioorganic & Medicinal Chemistry Letters. 11: 2355-9. PMID 11527730 DOI: 10.1016/S0960-894X(01)00457-7 |
0.359 |
|
| 2000 |
Combrink KD, Gulgeze HB, Yu KL, Pearce BC, Trehan AK, Wei J, Deshpande M, Krystal M, Torri A, Luo G, Cianci C, Danetz S, Tiley L, Meanwell NA. Salicylamide inhibitors of influenza virus fusion. Bioorganic & Medicinal Chemistry Letters. 10: 1649-52. PMID 10937716 DOI: 10.1016/S0960-894X(00)00335-8 |
0.34 |
|
| 2000 |
Blair WS, Lin P, Meanwell NA, Wallace OB. HIV-1 entry - an expanding portal for drug discovery. Drug Discovery Today. 5: 183-194. PMID 10790262 DOI: 10.1016/S1359-6446(00)01484-7 |
0.326 |
|
| 1999 |
Yu K, Ruediger E, Luo G, Cianci C, Danetz S, Tiley L, Trehan AK, Monkovic I, Pearce B, Martel A, Krystal M, Meanwell NA. Novel quinolizidine salicylamide influenza fusion inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 2177-2180. PMID 10465540 DOI: 10.1016/S0960-894X(99)00361-3 |
0.384 |
|
| 1999 |
Yu K, Civiello R, Roberts DGM, Seiler SM, Meanwell NA. Solid-phase synthesis of benzisothiazolones as serine protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 663-666. PMID 10201825 DOI: 10.1016/S0960-894X(99)00078-5 |
0.346 |
|
| 1999 |
Cianci C, Yu KL, Dischino DD, Harte W, Deshpande M, Luo G, Colonno RJ, Meanwell NA, Krystal M. pH-Dependent Changes in Photoaffinity Labeling Patterns of the H1 Influenza Virus Hemagglutinin by Using an Inhibitor of Viral Fusion Journal of Virology. 73: 1785-1794. DOI: 10.1128/Jvi.73.3.1785-1794.1999 |
0.338 |
|
| 1999 |
Dischino DD, Cianci C, Krystal M, Meanwell NA, Morimoto H, Pearce BC, Williams P, Yu K. Synthesis of 3H-labeled 2-hydroxy-N-[(1,3,3-trimethyl-[4,5,6-3H]cyclohexyl)methyl]-5-azidobenzamide, a photoaffinity analog of an influenza fusion inhibitor Journal of Labelled Compounds and Radiopharmaceuticals. 42: 965-974. DOI: 10.1002/(Sici)1099-1344(199910)42:10<965::Aid-Jlcr255>3.0.Co;2-K |
0.329 |
|
| 1998 |
Combrink KD, Gülgeze HB, Meanwell NA, Pearce BC, Zulan P, Bisacchi GS, Roberts DGM, Stanley P, Seiler SM. 1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase. Journal of Medicinal Chemistry. 41: 4854-4860. PMID 9822554 DOI: 10.1021/Jm9804580 |
0.366 |
|
| 1997 |
Luo G, Torri A, Harte WE, Danetz S, Cianci C, Tiley L, Day S, Mullaney D, Yu KL, Ouellet C, Dextraze P, Meanwell N, Colonno R, Krystal M. Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus. Journal of Virology. 71: 4062-4070. PMID 9094684 DOI: 10.1128/Jvi.71.5.4062-4070.1997 |
0.316 |
|
| 1996 |
Cianci C, Chung TDY, Meanwell N, Putz H, Hagen M, Colonno RJ, Krystal M. Identification of N-Hydroxamic Acid and N-Hydroxyimide Compounds that Inhibit the Influenza Virus Polymerase Antiviral Chemistry & Chemotherapy. 7: 353-360. DOI: 10.1177/095632029600700609 |
0.334 |
|
| 1996 |
Meanwell NA, Krystal M. Taking aim at a moving target — inhibitors of influenza virus Part 2: viral replication, packaging and release Drug Discovery Today. 1: 388-397. DOI: 10.1016/1359-6446(96)10035-0 |
0.318 |
|
| 1996 |
Meanwell NA, Krystal M. Taking aim at a moving target-inhibitors of influenza virus Part 1 : virus adsorption, entry and uncoating Drug Discovery Today. 1: 316-324. DOI: 10.1016/1359-6446(96)10029-5 |
0.307 |
|
| 1996 |
Sit SY, Ehrgott FJ, Gao J, Meanwell NA. 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor Bioorganic and Medicinal Chemistry Letters. 6: 499-504. DOI: 10.1016/0960-894X(96)00031-5 |
0.324 |
|
| 1995 |
St Laurent DR, Balasubramanian N, Han WT, Trehan A, Federici ME, Meanwell NA, Wright JJ, Seiler SM. Active site-directed thrombin inhibitors--II. Studies related to arginine/guanidine bioisosteres. Bioorganic & Medicinal Chemistry. 3: 1145-56. PMID 7582986 DOI: 10.1016/0968-0896(95)00103-N |
0.363 |
|
| 1995 |
Han WT, Trehan AK, Wright JJK, Federici ME, Seiler SM, Meanwell NA. Azetidin-2-one derivatives as inhibitors of thrombin. Bioorganic & Medicinal Chemistry. 3: 1123-1143. PMID 7582985 DOI: 10.1016/0968-0896(95)00101-L |
0.402 |
|
| 1994 |
Hewawasam P, Meanwell NA. A general method for the synthesis of isatins: Preparation of regiospecifically functionalized isatins from anilines Tetrahedron Letters. 35: 7303-7306. DOI: 10.1016/0040-4039(94)85299-5 |
0.315 |
|
| 1993 |
Balasubramanian N, St Laurent DR, Federici ME, Meanwell NA, Wright JJ, Schumacher WA, Seiler SM. Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series. Journal of Medicinal Chemistry. 36: 300-3. PMID 8423602 DOI: 10.1021/Jm00054A018 |
0.339 |
|
| 1993 |
Meanwell NA, Rosenfeld MJ, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Gamberdella M, Hartl KS, Zavoico GB. Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted alpha to the oxazole ring. Journal of Medicinal Chemistry. 36: 3871-83. PMID 8254619 DOI: 10.1021/Jm00076A017 |
0.343 |
|
| 1993 |
Meanwell NA, Hewawasam P, Thomas JA, Wright JJ, Russell JW, Gamberdella M, Goldenberg HJ, Seiler SM, Zavoico GB. Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives. Journal of Medicinal Chemistry. 36: 3251-64. PMID 8230115 DOI: 10.1021/Jm00074A005 |
0.326 |
|
| 1993 |
Meanwell NA, Romine JL, Rosenfeld MJ, Martin SW, Trehan AK, Wright JJ, Malley MF, Gougoutas JZ, Brassard CL, Buchanan JO. Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid. Journal of Medicinal Chemistry. 36: 3884-903. PMID 7504734 DOI: 10.1021/Jm00076A018 |
0.309 |
|
| 1993 |
Epperson JR, Hewawasam P, Meanwell NA, Boissard CG, Gribkoff VK, Post-Munson D. Synthesis and excitatory amino acid pharmacology of some novel quinoxalinediones Bioorganic and Medicinal Chemistry Letters. 3: 2801-2804. DOI: 10.1016/S0960-894X(01)80768-X |
0.312 |
|
| 1992 |
Meanwell NA, Rosenfeld MJ, Trehan AK, Romine JL, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Gamberdella M. Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety. Journal of Medicinal Chemistry. 35: 3498-512. PMID 1404231 DOI: 10.1021/Jm00097A007 |
0.382 |
|
| 1992 |
Meanwell NA, Rosenfeld MJ, Trehan AK, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Gamberdella M, Zavoico GB. Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives. Journal of Medicinal Chemistry. 35: 3483-97. PMID 1404230 DOI: 10.1021/Jm00097A006 |
0.35 |
|
| 1992 |
Meanwell NA, Rosenfeld MJ, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Seiler SM. Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic. Journal of Medicinal Chemistry. 35: 389-97. PMID 1370696 DOI: 10.1021/Jm00080A028 |
0.323 |
|
| 1992 |
Meanwell NA, Pearce BC, Roth HR, Smith EC, Wedding DL, Wright JJ, Buchanan JO, Baryla UM, Gamberdella M, Gillespie E. Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. Journal of Medicinal Chemistry. 35: 2672-87. PMID 1321910 DOI: 10.1021/Jm00092A019 |
0.356 |
|
| 1991 |
Fleming JS, Buchanan JO, Seiler SM, Meanwell NA. Antithrombotic activity of BMY-43351, a new imidazoquinoline with enhanced aqueous solubility Thrombosis Research. 63: 145-155. PMID 1948816 DOI: 10.1016/0049-3848(91)90277-4 |
0.321 |
|
| 1991 |
Meanwell NA, Roth HR, Smith EC, Wedding DL, Wright JJ, Fleming JS, Gillespie E. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. Journal of Medicinal Chemistry. 34: 2906-16. PMID 1654430 DOI: 10.1021/Jm00113A033 |
0.333 |
|
| 1991 |
Seiler S, Gillespie E, Arnold AJ, Brassard CL, Meanwell NA, Fleming JS. Imidazoquinoline derivatives: potent inhibitors of platelet cAMP phosphodiesterase which elevate cAMP levels and activate protein kinase in platelets. Thrombosis Research. 62: 31-42. PMID 1649498 DOI: 10.1016/0049-3848(91)90666-K |
0.316 |
|
| 1991 |
Meanwell NA, Roth HR, Smith ECR, Wedding DL, Wright JJK. Diethyl 2,4-dioxoimidazolidine-5-phosphonates: Horner-Wadsworth-Emmons reagents for the mild and efficient preparation of C-5 unsaturated hydantoin derivatives Journal of Organic Chemistry. 56: 6897-6904. DOI: 10.1021/Jo00024A036 |
0.303 |
|
| 1985 |
Johnson CR, Barbachyn MR, Meanwell NA, Stark CJ, Zeller JR. Utilization of Sulfoximines in the Synthesis of Optically Pure Substances Phosphorus Sulfur and Silicon and the Related Elements. 24: 151-163. DOI: 10.1080/03086648508073400 |
0.477 |
|
| 1985 |
Jones DN, Meanwell NA, Mirza SM. Convergent syntheses of 9-deoxy-12-phenylthioprostanoids and 9-deoxy-Δ8(12)-PGD1 derivatives Journal of the Chemical Society-Perkin Transactions 1. 16: 145-151. DOI: 10.1039/P19850000145 |
0.554 |
|
| 1984 |
Brown PJ, Jones DN, Khan MA, Meanwell NA, Richards PJ. Conjugate additions to α,β-unsaturated sulphoxides: syntheses of cyclopentenones and 9-deoxyprostanoids Journal of the Chemical Society-Perkin Transactions 1. 15: 2049-2060. DOI: 10.1039/P19840002049 |
0.528 |
|
| 1983 |
Brown PJ, Jones D, Khan M, Meanwell NA. Alkenyl sulphoxides as precursors to cyclopentenones and prostanoid β-side chains Tetrahedron Letters. 24: 405-408. DOI: 10.1016/S0040-4039(00)81420-3 |
0.502 |
|
| 1982 |
Meanwell NA, Johnson CR. The Preparation of β-Oxo Sulfoxides from Sulfinyl Chlorides and Trimethylsilyl Enol Ethers Synthesis. 1982: 283-284. DOI: 10.1055/S-1982-29780 |
0.463 |
|
| 1982 |
Johnson CR, Elliott RC, Meanwell NA. Ketone methylenation with optical resolution. Synthesis of (+)- and (−)-hop ether Tetrahedron Letters. 23: 5005-5008. DOI: 10.1016/S0040-4039(00)85558-6 |
0.481 |
|
| 1981 |
Johnson CR, Meanwell NA. Ketone methylenation with optical resolution. Total synthesis of the ginseng sesquiterpene (-)-.beta.-panasinsene and its enantiomer Journal of the American Chemical Society. 103: 7667-7669. DOI: 10.1021/Ja00415A052 |
0.449 |
|
| 1980 |
Bell R, Cottam PD, Davies J, Jones D, Meanwell NA. Reaction of allylsulphenic acid with alkynes to give thiolan 1-oxide derivatives Tetrahedron Letters. 21: 4379-4382. DOI: 10.1016/S0040-4039(00)77863-4 |
0.509 |
|
| 1979 |
Johnson CR, Bis KG, Cantillo JH, Meanwell NA, Reinhard MFD, Zeller JR, Vonk GP. Preparation and reactions of sulfonimidoyl chlorides Journal of Organic Chemistry. 44: 2055-2061. DOI: 10.1021/Jo00149A001 |
0.452 |
|
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