| Year |
Citation |
Score |
| 2023 |
Sterle M, Durcik M, Stevenson CEM, Henderson SR, Szili PE, Czikkely M, Lawson DM, Maxwell A, Cahard D, Kikelj D, Zidar N, Pal C, Mašič LP, Ilaš J, Tomašič T, et al. Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens. Acs Omega. 8: 24387-24395. PMID 37457471 DOI: 10.1021/acsomega.3c01930 |
0.383 |
|
| 2023 |
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, ... ... Maxwell A, et al. Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against and . Journal of Medicinal Chemistry. PMID 36634346 DOI: 10.1021/acs.jmedchem.2c01597 |
0.352 |
|
| 2022 |
Orritt KM, Feng L, Newell JF, Sutton JN, Grossman S, Germe T, Abbott LR, Jackson HL, Bury BKL, Maxwell A, McPhillie MJ, Fishwick CWG. design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region. Rsc Medicinal Chemistry. 13: 831-839. PMID 35919336 DOI: 10.1039/d2md00049k |
0.371 |
|
| 2022 |
McKie SJ, Desai P, Seol Y, Allen AM, Maxwell A, Neuman KC. Topoisomerase VI is a chirally-selective, preferential DNA decatenase. Elife. 11. PMID 35076393 DOI: 10.7554/eLife.67021 |
0.518 |
|
| 2021 |
M Orritt K, Maxwell A, Wg Fishwick C, J McPhillie M. Exploitation of a novel allosteric binding region in DNA gyrase and its implications for antibacterial drug discovery. Future Medicinal Chemistry. 13: 2125-2127. PMID 34605249 DOI: 10.4155/fmc-2021-0266 |
0.413 |
|
| 2021 |
Feng L, Mundy JEA, Stevenson CEM, Mitchenall LA, Lawson DM, Mi K, Maxwell A. The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33836580 DOI: 10.1073/pnas.2016705118 |
0.559 |
|
| 2021 |
Pyne ALB, Noy A, Main KHS, Velasco-Berrelleza V, Piperakis MM, Mitchenall LA, Cugliandolo FM, Beton JG, Stevenson CEM, Hoogenboom BW, Bates AD, Maxwell A, Harris SA. Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides. Nature Communications. 12: 1053. PMID 33594049 DOI: 10.1038/s41467-021-21243-y |
0.49 |
|
| 2021 |
McKie SJ, Neuman KC, Maxwell A. DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2000286. PMID 33480441 DOI: 10.1002/bies.202000286 |
0.512 |
|
| 2021 |
Kolarič A, Germe T, Hrast M, Stevenson CEM, Lawson DM, Burton NP, Vörös J, Maxwell A, Minovski N, Anderluh M. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. Nature Communications. 12: 150. PMID 33420011 DOI: 10.1038/s41467-020-20405-8 |
0.491 |
|
| 2020 |
Skok Ž, Barančoková M, Benek O, Cruz CD, Tammela P, Tomašič T, Zidar N, Mašič LP, Zega A, Stevenson CEM, Mundy JEA, Lawson DM, Maxwell A, Kikelj D, Ilaš J. Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors. Acs Medicinal Chemistry Letters. 11: 2433-2440. PMID 33329764 DOI: 10.1021/acsmedchemlett.0c00416 |
0.374 |
|
| 2020 |
Bush NG, Diez-Santos I, Abbott LR, Maxwell A. Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance. Molecules (Basel, Switzerland). 25. PMID 33271787 DOI: 10.3390/molecules25235662 |
0.427 |
|
| 2020 |
Waraich NF, Jain S, Colloms SD, Stark WM, Burton NP, Maxwell A. A novel decatenation assay for DNA topoisomerases using a singly-linked catenated substrate. Biotechniques. PMID 33000631 DOI: 10.2144/btn-2020-0059 |
0.489 |
|
| 2020 |
Henderson SR, Stevenson CEM, Malone B, Zholnerovych Y, Mitchenall LA, Pichowicz M, McGarry DH, Cooper IR, Charrier C, Salisbury AM, Lawson DM, Maxwell A. Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase. The Journal of Antimicrobial Chemotherapy. PMID 32728686 DOI: 10.1093/Jac/Dkaa286 |
0.517 |
|
| 2020 |
McKie SJ, Maxwell A, Neuman KC. Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques. Genes. 11. PMID 31941152 DOI: 10.3390/Genes11010092 |
0.499 |
|
| 2019 |
Bax BD, Murshudov G, Maxwell A, Germe T. DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion. Journal of Molecular Biology. PMID 31301408 DOI: 10.1016/J.Jmb.2019.07.008 |
0.618 |
|
| 2019 |
McAuley S, Huynh A, Howells A, Walpole C, Maxwell A, Nodwell JR. Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation. Cell Chemical Biology. PMID 31279606 DOI: 10.1016/J.Chembiol.2019.06.002 |
0.45 |
|
| 2019 |
Narramore S, Stevenson CEM, Maxwell A, Lawson DM, Fishwick CWG. New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorganic & Medicinal Chemistry. PMID 31257079 DOI: 10.1016/j.bmc.2019.06.015 |
0.553 |
|
| 2019 |
Collin F, Maxwell A. The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents. Journal of Molecular Biology. PMID 31181289 DOI: 10.1016/J.Jmb.2019.05.050 |
0.407 |
|
| 2019 |
Li X, Zhang Y, Zhou X, Hu X, Zhou Y, Liu D, Maxwell A, Mi K. The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress. Molecular Microbiology. PMID 30838726 DOI: 10.1111/Mmi.14235 |
0.454 |
|
| 2019 |
Ghilarov D, Stevenson CEM, Travin DY, Piskunova J, Serebryakova M, Maxwell A, Lawson DM, Severinov K. Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Molecular Cell. PMID 30661981 DOI: 10.1016/J.Molcel.2018.11.032 |
0.336 |
|
| 2018 |
Stracy M, Wollman AJ, Kaja E, Gapinski J, Lee JE, Leek VA, McKie SJ, Mitchenall LA, Maxwell A, Sherratt DJ, Leake MC, Zawadzki P. Single-molecule imaging of DNA gyrase activity in living Escherichia coli. Nucleic Acids Research. PMID 30445553 DOI: 10.1093/Nar/Gky1143 |
0.499 |
|
| 2018 |
Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, et al. Imidazopyrazinones (IPYs): non-quinolone bacterial topoisomerase inhibitors showing partial cross-resistance with quinolones. Journal of Medicinal Chemistry. PMID 29596745 DOI: 10.1021/Acs.Jmedchem.7B01892 |
0.346 |
|
| 2018 |
Germe T, Vörös J, Jeannot F, Taillier T, Stavenger RA, Bacqué E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Research. PMID 29596599 DOI: 10.1093/nar/gky241 |
0.581 |
|
| 2018 |
Germe T, Vörös J, Jeannot F, Taillier T, Stavenger RA, Bacqué E, Maxwell A, Bax BD. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Research. PMID 29538767 DOI: 10.1093/nar/gky181 |
0.508 |
|
| 2018 |
Wallace MD, Waraich NF, Debowski AW, Corral MG, Maxwell A, Mylne JS, Stubbs KA. Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action. Chemical Communications (Cambridge, England). PMID 29388638 DOI: 10.1039/C7Cc09518J |
0.438 |
|
| 2018 |
Colgan AM, Quinn HJ, Kary SC, Mitchenall LA, Maxwell A, Ds Cameron A, Dorman CJ. Negative supercoiling of DNA by gyrase is inhibited in Salmonella enterica serovar Typhimurium during adaptation to acid stress. Molecular Microbiology. PMID 29352745 DOI: 10.1111/Mmi.13911 |
0.527 |
|
| 2018 |
Mitchenall LA, Hipkin RE, Piperakis MM, Burton NP, Maxwell A. A rapid high-resolution method for resolving DNA topoisomers. Bmc Research Notes. 11: 37. PMID 29338757 DOI: 10.1186/S13104-018-3147-6 |
0.549 |
|
| 2018 |
Bush NG, Agarwal M, Henderson SR, Waraich NF, Maxwell A. DNA in a twist? How topoisomerases solve topological problems in DNA The Biochemist. 40: 26-31. DOI: 10.1042/bio04002026 |
0.52 |
|
| 2017 |
Buttner MJ, Schäfer M, Lawson DM, Maxwell A. Structural insights into simocyclinone as an antibiotic, effector ligand, and substrate. Fems Microbiology Reviews. PMID 29126195 DOI: 10.1093/Femsre/Fux055 |
0.436 |
|
| 2017 |
Ghilarov D, Serebryakova M, Stevenson CEM, Hearnshaw SJ, Volkov D, Maxwell A, Lawson DM, Severinov K. The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure (London, England : 1993). PMID 28943336 DOI: 10.1016/J.Str.2017.08.006 |
0.35 |
|
| 2017 |
Chan PF, Germe T, Bax BD, Huang J, Thalji RK, Bacqué E, Checchia A, Chen D, Cui H, Ding X, Ingraham K, McCloskey L, Raha K, Srikannathasan V, Maxwell A, et al. Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28507124 DOI: 10.1073/Pnas.1700721114 |
0.628 |
|
| 2017 |
Noy A, Maxwell A, Harris SA. Interference between Triplex and Protein Binding to Distal Sites on Supercoiled DNA. Biophysical Journal. PMID 28108011 DOI: 10.1016/J.Bpj.2016.12.034 |
0.58 |
|
| 2016 |
Nagaraja V, Godbole AA, Henderson SR, Maxwell A. DNA topoisomerase I and DNA gyrase as targets for TB therapy. Drug Discovery Today. PMID 27856347 DOI: 10.1016/J.Drudis.2016.11.006 |
0.498 |
|
| 2016 |
Bates AD, Maxwell A. Topology simplification: Important biological phenomenon or evolutionary relic?: Comment on "Disentangling DNA molecules" by Alexander Vologodskii. Physics of Life Reviews. 18: 144-146. PMID 27432778 DOI: 10.1016/J.Plrev.2016.07.007 |
0.513 |
|
| 2016 |
Djaout K, Singh V, Boum Y, Katawera V, Becker HF, Bush NG, Hearnshaw SJ, Pritchard JE, Bourbon P, Madrid PB, Maxwell A, Mizrahi V, Myllykallio H, Ekins S. Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis. Scientific Reports. 6: 27792. PMID 27283217 DOI: 10.1038/Srep27792 |
0.406 |
|
| 2016 |
Austin MJ, Hearnshaw SJ, Mitchenall LA, McDermott PJ, Howell LA, Maxwell A, Searcey M. A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents Medchemcomm. 7: 1387-1391. DOI: 10.1039/C6Md00229C |
0.442 |
|
| 2015 |
Evans-Roberts KM, Mitchenall LA, Wall MK, Leroux J, Mylne JS, Maxwell A. DNA Gyrase is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana. The Journal of Biological Chemistry. PMID 26663076 DOI: 10.1074/Jbc.M115.689554 |
0.481 |
|
| 2015 |
Bush NG, Evans-Roberts K, Maxwell A. DNA Topoisomerases. Ecosal Plus. 6. PMID 26435256 DOI: 10.1128/ecosalplus.ESP-0010-2014 |
0.556 |
|
| 2015 |
Schäfer M, Le TB, Hearnshaw SJ, Maxwell A, Challis GL, Wilkinson B, Buttner MJ. SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone. Journal of Molecular Biology. 427: 2192-204. PMID 25861759 DOI: 10.1016/J.Jmb.2015.03.019 |
0.478 |
|
| 2015 |
Hearnshaw SJ, Chung TT, Stevenson CE, Maxwell A, Lawson DM. The role of monovalent cations in the ATPase reaction of DNA gyrase. Acta Crystallographica. Section D, Biological Crystallography. 71: 996-1005. PMID 25849408 DOI: 10.1107/S1399004715002916 |
0.422 |
|
| 2014 |
Thomson NH, Santos S, Mitchenall LA, Stuchinskaya T, Taylor JA, Maxwell A. DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases. Scientific Reports. 4: 6158. PMID 25142513 DOI: 10.1038/Srep06158 |
0.534 |
|
| 2014 |
Hearnshaw SJ, Edwards MJ, Stevenson CE, Lawson DM, Maxwell A. A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition. Journal of Molecular Biology. 426: 2023-33. PMID 24594357 DOI: 10.1016/J.Jmb.2014.02.017 |
0.487 |
|
| 2014 |
Thompson RE, Collin F, Maxwell A, Jolliffe KA, Payne RJ. Synthesis of full length and truncated microcin B17 analogues as DNA gyrase poisons. Organic & Biomolecular Chemistry. 12: 1570-8. PMID 24448886 DOI: 10.1039/C3Ob42516A |
0.454 |
|
| 2013 |
Karkare S, Brown AC, Parish T, Maxwell A. Identification of the likely translational start of Mycobacterium tuberculosis GyrB. Bmc Research Notes. 6: 274. PMID 23856181 DOI: 10.1186/1756-0500-6-274 |
0.339 |
|
| 2013 |
Collin F, Thompson RE, Jolliffe KA, Payne RJ, Maxwell A. Fragments of the bacterial toxin microcin B17 as gyrase poisons. Plos One. 8: e61459. PMID 23593482 DOI: 10.1371/Journal.Pone.0061459 |
0.412 |
|
| 2013 |
Bates AD, Noy A, Piperakis MM, Harris SA, Maxwell A. Small DNA circles as probes of DNA topology. Biochemical Society Transactions. 41: 565-70. PMID 23514155 DOI: 10.1042/Bst20120320 |
0.574 |
|
| 2013 |
Taylor JA, Mitchenall LA, Rejzek M, Field RA, Maxwell A. Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI. Plos One. 8: e58010. PMID 23469129 DOI: 10.1371/Journal.Pone.0058010 |
0.518 |
|
| 2013 |
Tao J, Han J, Wu H, Hu X, Deng J, Fleming J, Maxwell A, Bi L, Mi K. Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance. Nucleic Acids Research. 41: 2370-81. PMID 23275532 DOI: 10.1093/Nar/Gks1351 |
0.587 |
|
| 2013 |
Karkare S, Chung TT, Collin F, Mitchenall LA, McKay AR, Greive SJ, Meyer JJ, Lall N, Maxwell A. The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. The Journal of Biological Chemistry. 288: 5149-56. PMID 23275348 DOI: 10.1074/Jbc.M112.419069 |
0.495 |
|
| 2012 |
Smith AB, López-Villarejo J, Diago-Navarro E, Mitchenall LA, Barendregt A, Heck AJ, Lemonnier M, Maxwell A, Díaz-Orejas R. A Common Origin for the Bacterial Toxin-Antitoxin Systems parD and ccd, Suggested by Analyses of Toxin/Target and Toxin/Antitoxin Interactions Plos One. 7. PMID 23029540 DOI: 10.1371/Journal.Pone.0046499 |
0.508 |
|
| 2012 |
Karkare S, Yousafzai F, Mitchenall LA, Maxwell A. The role of Ca²⁺ in the activity of Mycobacterium tuberculosis DNA gyrase. Nucleic Acids Research. 40: 9774-87. PMID 22844097 DOI: 10.1093/Nar/Gks704 |
0.409 |
|
| 2012 |
Taylor JA, Burton NP, Maxwell A. High-throughput microtitre plate-based assay for DNA topoisomerases. Methods in Molecular Biology (Clifton, N.J.). 815: 229-39. PMID 22130995 DOI: 10.1007/978-1-61779-424-7_17 |
0.585 |
|
| 2011 |
Collin F, Karkare S, Maxwell A. Exploiting bacterial DNA gyrase as a drug target: current state and perspectives. Applied Microbiology and Biotechnology. 92: 479-97. PMID 21904817 DOI: 10.1007/S00253-011-3557-Z |
0.514 |
|
| 2011 |
Wu J, Zhang Z, Mitchenall LA, Maxwell A, Deng J, Zhang H, Zhou Y, Chen YY, Wang DC, Zhang XE, Bi L. The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage. Nucleic Acids Research. 39: 8488-502. PMID 21745817 DOI: 10.1093/Nar/Gkr553 |
0.471 |
|
| 2011 |
Alt S, Mitchenall LA, Maxwell A, Heide L. Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. The Journal of Antimicrobial Chemotherapy. 66: 2061-9. PMID 21693461 DOI: 10.1093/Jac/Dkr247 |
0.595 |
|
| 2011 |
Bates AD, Berger JM, Maxwell A. The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks. Nucleic Acids Research. 39: 6327-39. PMID 21525132 DOI: 10.1093/Nar/Gkr258 |
0.558 |
|
| 2011 |
Le TB, Stevenson CE, Fiedler HP, Maxwell A, Lawson DM, Buttner MJ. Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression. Journal of Molecular Biology. 408: 40-56. PMID 21354180 DOI: 10.1016/J.Jmb.2011.02.035 |
0.366 |
|
| 2011 |
Edwards MJ, Williams MA, Maxwell A, McKay AR. Mass spectrometry reveals that the antibiotic simocyclinone D8 binds to DNA gyrase in a "bent-over" conformation: evidence of positive cooperativity in binding. Biochemistry. 50: 3432-40. PMID 21338149 DOI: 10.1021/Bi101691K |
0.526 |
|
| 2011 |
Pitts SL, Liou GF, Mitchenall LA, Burgin AB, Maxwell A, Neuman KC, Osheroff N. Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Research. 39: 4808-17. PMID 21300644 DOI: 10.1093/Nar/Gkr018 |
0.439 |
|
| 2011 |
Hegde SS, Vetting MW, Mitchenall LA, Maxwell A, Blanchard JS. Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor Antimicrobial Agents and Chemotherapy. 55: 110-117. PMID 20937785 DOI: 10.1128/Aac.01158-10 |
0.51 |
|
| 2010 |
Yuan J, Sterckx Y, Mitchenall LA, Maxwell A, Loris R, Waldor MK. Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. The Journal of Biological Chemistry. 285: 40397-408. PMID 20952390 DOI: 10.1074/Jbc.M110.138776 |
0.601 |
|
| 2010 |
Evans-Roberts KM, Breuer C, Wall MK, Sugimoto-Shirasu K, Maxwell A. Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit. Plos One. 5: e9899. PMID 20360860 DOI: 10.1371/Journal.Pone.0009899 |
0.593 |
|
| 2010 |
Bates AD, Maxwell A. The role of ATP in the reactions of type II DNA topoisomerases. Biochemical Society Transactions. 38: 438-42. PMID 20298198 DOI: 10.1042/Bst0380438 |
0.554 |
|
| 2010 |
Burrell MR, Burton NP, Maxwell A. A high-throughput assay for DNA topoisomerases and other enzymes, based on DNA triplex formation. Methods in Molecular Biology (Clifton, N.J.). 613: 257-66. PMID 19997889 DOI: 10.1007/978-1-60327-418-0_16 |
0.575 |
|
| 2010 |
Sissi C, Vazquez E, Chemello A, Mitchenall LA, Maxwell A, Palumbo M. Mapping Simocyclinone D8 Interaction with DNA Gyrase: Evidence for a New Binding Site on GyrB Antimicrobial Agents and Chemotherapy. 54: 213-220. PMID 19858260 DOI: 10.1128/Aac.00972-09 |
0.523 |
|
| 2009 |
Evans-Roberts K, Maxwell A. DNA Topoisomerases. Ecosal Plus. 3. PMID 26443761 DOI: 10.1128/ecosalplus.4.4.9 |
0.539 |
|
| 2009 |
Edwards MJ, Flatman RH, Mitchenall LA, Stevenson CE, Le TB, Clarke TA, McKay AR, Fiedler HP, Buttner MJ, Lawson DM, Maxwell A. A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase. Science (New York, N.Y.). 326: 1415-8. PMID 19965760 DOI: 10.1126/Science.1179123 |
0.527 |
|
| 2009 |
Edwards MJ, Flatman RH, Mitchenall LA, Stevenson CE, Maxwell A, Lawson DM. Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 846-8. PMID 19652356 DOI: 10.1107/S1744309109028097 |
0.495 |
|
| 2009 |
Le TB, Fiedler HP, den Hengst CD, Ahn SK, Maxwell A, Buttner MJ. Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus. Molecular Microbiology. 72: 1462-74. PMID 19460097 DOI: 10.1111/J.1365-2958.2009.06735.X |
0.52 |
|
| 2009 |
Stuchinskaya T, Mitchenall LA, Schoeffler AJ, Corbett KD, Berger JM, Bates AD, Maxwell A. How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. Journal of Molecular Biology. 385: 1397-408. PMID 19094994 DOI: 10.1016/J.Jmb.2008.11.056 |
0.565 |
|
| 2008 |
Sissi C, Chemello A, Vazquez E, Mitchenall LA, Maxwell A, Palumbo M. DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action. Biochemistry. 47: 8538-45. PMID 18642932 DOI: 10.1021/Bi800480J |
0.499 |
|
| 2008 |
Anderle C, Stieger M, Burrell M, Reinelt S, Maxwell A, Page M, Heide L. Biological activities of novel gyrase inhibitors of the aminocoumarin class. Antimicrobial Agents and Chemotherapy. 52: 1982-90. PMID 18347114 DOI: 10.1128/Aac.01235-07 |
0.582 |
|
| 2008 |
Hashimi SM, Huang G, Maxwell A, Birch RG. DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties. Antimicrobial Agents and Chemotherapy. 52: 1382-90. PMID 18268084 DOI: 10.1128/Aac.01551-07 |
0.533 |
|
| 2007 |
Breuer C, Stacey NJ, West CE, Zhao Y, Chory J, Tsukaya H, Azumi Y, Maxwell A, Roberts K, Sugimoto-Shirasu K. BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis. The Plant Cell. 19: 3655-68. PMID 18055605 DOI: 10.1105/Tpc.107.054833 |
0.493 |
|
| 2007 |
Richter SN, Giaretta G, Comuzzi V, Leo E, Mitchenall LA, Fisher LM, Maxwell A, Palumbo M. Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases. Nucleic Acids Research. 35: 6075-85. PMID 17766248 DOI: 10.1093/Nar/Gkm653 |
0.525 |
|
| 2007 |
Bates AD, Maxwell A. Energy coupling in type II topoisomerases: why do they hydrolyze ATP? Biochemistry. 46: 7929-41. PMID 17580973 DOI: 10.1021/Bi700789G |
0.49 |
|
| 2007 |
Costenaro L, Grossmann JG, Ebel C, Maxwell A. Modular structure of the full-length DNA gyrase B subunit revealed by small-angle X-ray scattering. Structure (London, England : 1993). 15: 329-39. PMID 17355868 DOI: 10.1016/J.Str.2007.01.013 |
0.464 |
|
| 2007 |
Nöllmann M, Stone MD, Bryant Z, Gore J, Crisona NJ, Hong SC, Mitelheiser S, Maxwell A, Bustamante C, Cozzarelli NR. Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque. Nature Structural & Molecular Biology. 14: 264-71. PMID 17334374 DOI: 10.1038/Nsmb1213 |
0.499 |
|
| 2007 |
Parks WM, Bottrill AR, Pierrat OA, Durrant MC, Maxwell A. The action of the bacterial toxin, microcin B17, on DNA gyrase. Biochimie. 89: 500-7. PMID 17276574 DOI: 10.1016/J.Biochi.2006.12.005 |
0.509 |
|
| 2007 |
Hashimi SM, Wall MK, Smith AB, Maxwell A, Birch RG. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrobial Agents and Chemotherapy. 51: 181-7. PMID 17074789 DOI: 10.1128/Aac.00918-06 |
0.601 |
|
| 2006 |
Burlison JA, Neckers L, Smith AB, Maxwell A, Blagg BS. Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90. Journal of the American Chemical Society. 128: 15529-36. PMID 17132020 DOI: 10.1021/Ja065793P |
0.395 |
|
| 2006 |
Huang YY, Deng JY, Gu J, Zhang ZP, Maxwell A, Bi LJ, Chen YY, Zhou YF, Yu ZN, Zhang XE. The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA). Nucleic Acids Research. 34: 5650-9. PMID 17038336 DOI: 10.1093/Nar/Gkl695 |
0.588 |
|
| 2006 |
Stacey NJ, Kuromori T, Azumi Y, Roberts G, Breuer C, Wada T, Maxwell A, Roberts K, Sugimoto-Shirasu K. Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination. The Plant Journal : For Cell and Molecular Biology. 48: 206-16. PMID 17018031 DOI: 10.1111/J.1365-313X.2006.02867.X |
0.507 |
|
| 2006 |
Smith AB, Maxwell A. A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site. Nucleic Acids Research. 34: 4667-76. PMID 16963775 DOI: 10.1093/Nar/Gkl636 |
0.6 |
|
| 2006 |
Maxwell A, Burton NP, O'Hagan N. High-throughput assays for DNA gyrase and other topoisomerases. Nucleic Acids Research. 34: e104. PMID 16936317 DOI: 10.1093/Nar/Gkl504 |
0.578 |
|
| 2006 |
Oram M, Travers AA, Howells AJ, Maxwell A, Pato ML. Dissection of the bacteriophage Mu strong gyrase site (SGS): significance of the SGS right arm in Mu biology and DNA gyrase mechanism. Journal of Bacteriology. 188: 619-32. PMID 16385052 DOI: 10.1128/Jb.188.2.619-632.2006 |
0.476 |
|
| 2005 |
Sugimoto-Shirasu K, Roberts GR, Stacey NJ, McCann MC, Maxwell A, Roberts K. RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth. Proceedings of the National Academy of Sciences of the United States of America. 102: 18736-41. PMID 16339310 DOI: 10.1073/Pnas.0505883102 |
0.506 |
|
| 2005 |
Maxwell A, Costenaro L, Mitelheiser S, Bates AD. Coupling ATP hydrolysis to DNA strand passage in type IIA DNA topoisomerases. Biochemical Society Transactions. 33: 1460-1464. PMID 16246146 DOI: 10.1042/Bst20051460 |
0.502 |
|
| 2005 |
Sissi C, Marangon E, Chemello A, Noble CG, Maxwell A, Palumbo M. The effects of metal ions on the structure and stability of the DNA gyrase B protein. Journal of Molecular Biology. 353: 1152-1160. PMID 16223508 DOI: 10.1016/J.Jmb.2005.09.043 |
0.38 |
|
| 2005 |
Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS. Biochemistry: A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA Science. 308: 1480-1483. PMID 15933203 DOI: 10.1126/Science.1110699 |
0.554 |
|
| 2005 |
Manjunatha UH, Maxwell A, Nagaraja V. A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism. Nucleic Acids Research. 33: 3085-94. PMID 15930158 DOI: 10.1093/Nar/Gki622 |
0.592 |
|
| 2005 |
Pierrat OA, Maxwell A. Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase. Biochemistry. 44: 4204-15. PMID 15766248 DOI: 10.1021/Bi0478751 |
0.63 |
|
| 2005 |
Edmondson AC, Song D, Alvarez LA, Wall MK, Almond D, McClellan DA, Maxwell A, Nielsen BL. Characterization of a mitochondrially targeted single-stranded DNA-binding protein in Arabidopsis thaliana. Molecular Genetics and Genomics : Mgg. 273: 115-22. PMID 15744502 DOI: 10.1007/S00438-004-1106-5 |
0.481 |
|
| 2005 |
Flatman RH, Howells AJ, Heide L, Fiedler HP, Maxwell A. Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action. Antimicrobial Agents and Chemotherapy. 49: 1093-100. PMID 15728908 DOI: 10.1128/Aac.49.3.1093-1100.2005 |
0.556 |
|
| 2005 |
Costenaro L, Grossmann JG, Ebel C, Maxwell A. Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase a subunit. Structure (London, England : 1993). 13: 287-96. PMID 15698572 DOI: 10.1016/J.Str.2004.12.011 |
0.533 |
|
| 2004 |
Gruger T, Nitiss JL, Maxwell A, Zechiedrich EL, Heisig P, Seeber S, Pommier Y, Strumberg D. A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II. Antimicrobial Agents and Chemotherapy. 48: 4495-504. PMID 15561817 DOI: 10.1128/Aac.48.12.4495-4504.2004 |
0.546 |
|
| 2004 |
Li K, Pasternak C, Härtig E, Haberzettl K, Maxwell A, Klug G. Thioredoxin can influence gene expression by affecting gyrase activity. Nucleic Acids Research. 32: 4563-75. PMID 15328368 DOI: 10.1093/Nar/Gkh794 |
0.375 |
|
| 2004 |
Wall MK, Mitchenall LA, Maxwell A. Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria Proceedings of the National Academy of Sciences of the United States of America. 101: 7821-7826. PMID 15136745 DOI: 10.1073/Pnas.0400836101 |
0.575 |
|
| 2004 |
Heddle JG, Mitelheiser S, Maxwell A, Thomson NH. Nucleotide binding to DNA gyrase causes loss of DNA wrap. Journal of Molecular Biology. 337: 597-610. PMID 15019780 DOI: 10.1016/J.Jmb.2004.01.049 |
0.617 |
|
| 2003 |
Oram M, Howells AJ, Maxwell A, Pato ML. A biochemical analysis of the interaction of DNA gyrase with the bacteriophage Mu, pSC101 and pBR322 strong gyrase sites: the role of DNA sequence in modulating gyrase supercoiling and biological activity. Molecular Microbiology. 50: 333-47. PMID 14507384 DOI: 10.1046/J.1365-2958.2003.03690.X |
0.532 |
|
| 2003 |
Pierrat OA, Maxwell A. The action of the bacterial toxin microcin B17. Insight into the cleavage-religation reaction of DNA gyrase. Journal of Biological Chemistry. 278: 35016-35023. PMID 12829716 DOI: 10.1074/Jbc.M304516200 |
0.537 |
|
| 2003 |
Noble CG, Barnard FM, Maxwell A. Quinolone-DNA Interaction: Sequence-Dependent Binding to Single-Stranded DNA Reflects the Interaction within the Gyrase-DNA Complex Antimicrobial Agents and Chemotherapy. 47: 854-862. PMID 12604512 DOI: 10.1128/Aac.47.3.854-862.2003 |
0.59 |
|
| 2003 |
Maxwell A, Lawson DM. The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Current Topics in Medicinal Chemistry. 3: 283-303. PMID 12570764 DOI: 10.2174/1568026033452500 |
0.462 |
|
| 2002 |
Strumberg D, Nitiss JL, Dong J, Walker J, Nicklaus MC, Kohn KW, Heddle JG, Maxwell A, Seeber S, Pommier Y. Importance of the Fourth Alpha-Helix within the CAP Homology Domain of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone Action Antimicrobial Agents and Chemotherapy. 46: 2735-2746. PMID 12183223 DOI: 10.1128/Aac.46.9.2735-2746.2002 |
0.51 |
|
| 2002 |
Campbell S, Maxwell A. The ATP-operated Clamp of Human DNA Topoisomerase IIα: Hyperstimulation of ATPase by “Piggy-back” Binding Journal of Molecular Biology. 320: 171-188. PMID 12079377 DOI: 10.1016/S0022-2836(02)00461-8 |
0.584 |
|
| 2002 |
Noble CG, Maxwell A. The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism. Journal of Molecular Biology. 318: 361-371. PMID 12051843 DOI: 10.1016/S0022-2836(02)00049-9 |
0.506 |
|
| 2002 |
Hockings SC, Maxwell A. Identification of four GyrA residues involved in the DNA breakage-reunion reaction of DNA gyrase. Journal of Molecular Biology. 318: 351-9. PMID 12051842 DOI: 10.1016/S0022-2836(02)00048-7 |
0.564 |
|
| 2002 |
Heddle J, Maxwell A. Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB Antimicrobial Agents and Chemotherapy. 46: 1805-1815. PMID 12019094 DOI: 10.1128/Aac.46.6.1805-1815.2002 |
0.547 |
|
| 2001 |
Sissi C, Perdonà E, Domenici E, Feriani A, Howells AJ, Maxwell A, Palumbo M. Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions. Journal of Molecular Biology. 311: 195-203. PMID 11469868 DOI: 10.1006/Jmbi.2001.4838 |
0.396 |
|
| 2001 |
Zamble DB, Miller DA, Heddle JG, Maxwell A, Walsh CT, Hollfelder F. In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites. Proceedings of the National Academy of Sciences of the United States of America. 98: 7712-7. PMID 11427730 DOI: 10.1073/Pnas.141225698 |
0.602 |
|
| 2001 |
Barnard FM, Maxwell A. Interaction between DNA Gyrase and Quinolones: Effects of Alanine Mutations at GyrA Subunit Residues Ser83 and Asp87 Antimicrobial Agents and Chemotherapy. 45: 1994-2000. PMID 11408214 DOI: 10.1128/Aac.45.7.1994-2000.2001 |
0.55 |
|
| 2001 |
Heddle JG, Lu T, Zhao X, Drlica K, Maxwell A. gyrB-225, a Mutation of DNA Gyrase that Compensates for Topoisomerase I Deficiency: Investigation of its Low Activity and Quinolone Hypersensitivity Journal of Molecular Biology. 309: 1219-1231. PMID 11399091 DOI: 10.1006/Jmbi.2001.4733 |
0.597 |
|
| 2001 |
Heddle JG, Blance SJ, Zamble DB, Hollfelder F, Miller DA, Wentzell LM, Walsh CT, Maxwell A. The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. Journal of Molecular Biology. 307: 1223-34. PMID 11292337 DOI: 10.1006/Jmbi.2001.4562 |
0.582 |
|
| 2001 |
Williams NL, Howells AJ, Maxwell A. Locking the ATP-operated clamp of DNA gyrase: probing the mechanism of strand passage. Journal of Molecular Biology. 306: 969-84. PMID 11237612 DOI: 10.1006/Jmbi.2001.4468 |
0.584 |
|
| 2001 |
Pingoud A, Jeltsch A, Maxwell A, Sherratt D. Enzymes that keep DNA under control: Meeting: DNA enzymes: structures and mechanisms Embo Reports. 2: 271-276. DOI: 10.1093/Embo-Reports/Kve073 |
0.511 |
|
| 2000 |
Wentzell LM, Maxwell A. The Complex of DNA Gyrase and Quinolone Drugs on DNA Forms a Barrier to the T7 DNA Polymerase Replication Complex Journal of Molecular Biology. 304: 779-791. PMID 11124026 DOI: 10.1006/Jmbi.2000.4266 |
0.596 |
|
| 2000 |
Heddle JG, Barnard FM, Wentzell LM, Maxwell A. The interaction of drugs with DNA gyrase: a model for the molecular basis of quinolone action. Nucleosides, Nucleotides & Nucleic Acids. 19: 1249-1264. PMID 11097055 DOI: 10.1080/15257770008033048 |
0.543 |
|
| 2000 |
Hammonds TR, Foster SR, Maxwell A. Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIα by selective mutagenesis Journal of Molecular Biology. 300: 481-491. PMID 10884345 DOI: 10.1006/Jmbi.2000.3892 |
0.438 |
|
| 2000 |
Blance SJ, Williams NL, Preston ZA, Bishara J, Smyth MS, Maxwell A. Temperature-sensitive suppressor mutations of the Escherichia coli DNA gyrase B protein. Protein Science : a Publication of the Protein Society. 9: 1035-7. PMID 10850814 DOI: 10.1110/Ps.9.5.1035 |
0.358 |
|
| 2000 |
Chatterji M, Unniraman S, Maxwell A, Nagaraja V. The additional 165 amino acids in the B protein of Escherichia coli DNA gyrase have an important role in DNA binding Journal of Biological Chemistry. 275: 22888-22894. PMID 10764756 DOI: 10.1074/Jbc.M001047200 |
0.608 |
|
| 1999 |
Maxwell A, Howells AJ. Overexpression and Purification of Bacterial DNA Gyrase Methods of Molecular Biology. 94: 135-144. PMID 12844869 DOI: 10.1385/1-59259-259-7:135 |
0.59 |
|
| 1999 |
Williams NL, Maxwell A. Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis. Biochemistry. 38: 14157-64. PMID 10571989 DOI: 10.1021/Bi991478M |
0.607 |
|
| 1999 |
Kampranis SC, Howells AJ, Maxwell A. The interaction of DNA gyrase with the bacterial toxin CcdB: evidence for the existence of two gyrase-CcdB complexes. Journal of Molecular Biology. 293: 733-744. PMID 10543963 DOI: 10.1006/Jmbi.1999.3182 |
0.467 |
|
| 1999 |
Williams NL, Maxwell A. Probing the two-gate mechanism of DNA gyrase using cysteine cross-linking. Biochemistry. 38: 13502-11. PMID 10521257 DOI: 10.1021/Bi9912488 |
0.53 |
|
| 1999 |
Kampranis SC, Bates AD, Maxwell A. A model for the mechanism of strand passage by DNA gyrase. Proceedings of the National Academy of Sciences of the United States of America. 96: 8414-8419. PMID 10411889 DOI: 10.1073/Pnas.96.15.8414 |
0.591 |
|
| 1999 |
Maxwell A. DNA gyrase as a drug target Biochemical Society Transactions. 27: 48-53. PMID 10093705 DOI: 10.1042/Bst0270048 |
0.557 |
|
| 1999 |
Kampranis SC, Gormley NA, Tranter R, Orphanides G, Maxwell A. Probing the binding of coumarins and cyclothialidines to DNA gyrase. Biochemistry. 38: 1967-1976. PMID 10026280 DOI: 10.1021/Bi982320P |
0.444 |
|
| 1999 |
Maxwell A. DNA gyrase and the mechanism of DNA supercoiling Biochemical Society Transactions. 27. DOI: 10.1042/Bst027A087C |
0.588 |
|
| 1998 |
Gardiner LP, Roper DI, Hammonds TR, Maxwell A. The N-terminal domain of human topoisomerase IIalpha is a DNA-dependent ATPase. Biochemistry. 37: 16997-17004. PMID 9836594 DOI: 10.1021/Bi9818321 |
0.503 |
|
| 1998 |
Kampranis SC, Maxwell A. Hydrolysis of ATP at Only One GyrB Subunit Is Sufficient to Promote Supercoiling by DNA Gyrase Journal of Biological Chemistry. 273: 26305-26309. PMID 9756859 DOI: 10.1074/Jbc.273.41.26305 |
0.485 |
|
| 1998 |
Kampranis SC, Maxwell A. The DNA Gyrase-Quinolone Complex ATP HYDROLYSIS AND THE MECHANISM OF DNA CLEAVAGE Journal of Biological Chemistry. 273: 22615-22626. PMID 9712890 DOI: 10.1074/Jbc.273.35.22615 |
0.627 |
|
| 1998 |
Kampranis SC, Maxwell A. Conformational Changes in DNA Gyrase Revealed by Limited Proteolysis Journal of Biological Chemistry. 273: 22606-22614. PMID 9712889 DOI: 10.1074/Jbc.273.35.22606 |
0.56 |
|
| 1998 |
Smith CV, Maxwell A. Identification of a residue involved in transition-state stabilization in the ATPase reaction of DNA gyrase Biochemistry. 37: 9658-9667. PMID 9657678 DOI: 10.1021/Bi9801309 |
0.449 |
|
| 1998 |
Hammonds TR, Maxwell A, Jenkins JR. Use of a rapid throughput in vivo screen to investigate inhibitors of eukaryotic topoisomerase II enzymes. Antimicrobial Agents and Chemotherapy. 42: 889-94. PMID 9559802 DOI: 10.1128/Aac.42.4.889 |
0.507 |
|
| 1998 |
Maxwell A, Critchlow SE. Mode of Action Handbook of Experimental Pharmacology. 127: 119-166. DOI: 10.1007/978-3-642-80364-2_4 |
0.397 |
|
| 1997 |
Hammonds TR, Maxwell A. The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIα Journal of Biological Chemistry. 272: 32696-32703. PMID 9405488 DOI: 10.1074/Jbc.272.51.32696 |
0.597 |
|
| 1997 |
Bates AD, Maxwell A. DNA topology: Topoisomerases keep it simple Current Biology. 7. PMID 9382831 DOI: 10.1016/S0960-9822(06)00403-9 |
0.584 |
|
| 1997 |
Critchlow SE, O’Dea MH, Howells AJ, Couturier M, Gellert M, Maxwell A. The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription. Journal of Molecular Biology. 273: 826-839. PMID 9367775 DOI: 10.1006/Jmbi.1997.1357 |
0.622 |
|
| 1997 |
Morais Cabral JH, Jackson AP, Smith CV, Shikotra N, Maxwell A, Liddington RC. Crystal structure of the breakage-reunion domain of DNA gyrase. Nature. 388: 903-6. PMID 9278055 DOI: 10.1038/42294 |
0.66 |
|
| 1997 |
Cove ME, Tingey AP, Maxwell A. DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs Nucleic Acids Research. 25: 2716-2722. PMID 9207016 DOI: 10.1093/Nar/25.14.2716 |
0.571 |
|
| 1997 |
Cullis PM, Maxwell aA, Weiner DP. Exploiting nucleotide thiophosphates to probe mechanistic aspects of Escherichia coli DNA gyrase. Biochemistry. 36: 6059-6068. PMID 9166776 DOI: 10.1021/Bi962725E |
0.479 |
|
| 1997 |
Maxwell A. DNA gyrase as a drug target Trends in Microbiology. 5: 102-109. PMID 9080608 DOI: 10.1016/S0966-842X(96)10085-8 |
0.57 |
|
| 1996 |
Tingey AP, Maxwell A. Probing the Role of the ATP-Operated Clamp in the Strand-Passage Reaction of DNA Gyrase Nucleic Acids Research. 24: 4868-4873. PMID 9016655 DOI: 10.1093/Nar/24.24.4868 |
0.622 |
|
| 1996 |
Kampranis SC, Maxwell A. Conversion Of Dna Gyrase Into A Conventional Type Ii Topoisomerase Proceedings of the National Academy of Sciences of the United States of America. 93: 14416-14421. PMID 8962066 DOI: 10.1073/Pnas.93.25.14416 |
0.633 |
|
| 1996 |
Oram M, Dosanjh B, Gormley NA, Smith CV, Fisher LM, Maxwell A, Duncan K. Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase. Antimicrobial Agents and Chemotherapy. 40: 473-6. PMID 8834902 DOI: 10.1128/Aac.40.2.473 |
0.52 |
|
| 1996 |
Gormley NA, Orphanides G, Meyer A, Cullis PM, Maxwell A. The interaction of coumarin antibiotics with fragments of DNA gyrase B protein. Biochemistry. 35: 5083-5092. PMID 8664301 DOI: 10.1021/Bi952888N |
0.541 |
|
| 1996 |
Critchlow SE, Maxwell A. DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex. Biochemistry. 35: 7387-7393. PMID 8652515 DOI: 10.1021/Bi9603175 |
0.613 |
|
| 1996 |
Maxwell A. Protein gates in DNA topoisomerase II. Nature Structural & Molecular Biology. 3: 109-112. PMID 8564532 DOI: 10.1038/Nsb0296-109 |
0.587 |
|
| 1996 |
Lewis RJ, Singh OM, Smith CV, Skarzynski T, Maxwell A, Wonacott AJ, Wigley DB. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. The Embo Journal. 15: 1412-1420. DOI: 10.1002/J.1460-2075.1996.Tb00483.X |
0.518 |
|
| 1995 |
Ali JA, Orphanides G, Maxwell A. Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein. Biochemistry. 34: 9801-9808. PMID 7626649 DOI: 10.1021/Bi00030A018 |
0.457 |
|
| 1994 |
Orphanides G, Maxwell A. Evidence for a conformational change in the DNA gyrase–DNA complex from hydroxyl radical footprinting Nucleic Acids Research. 22: 1567-1575. PMID 8202356 DOI: 10.1093/Nar/22.9.1567 |
0.569 |
|
| 1994 |
Gilbert EJ, Maxwell A. The 24 kDa N‐terminal sub‐domain of the DNA gyrase B protein binds coumarin drugs Molecular Microbiology. 12: 365-373. PMID 8065258 DOI: 10.1111/J.1365-2958.1994.Tb01026.X |
0.458 |
|
| 1994 |
Lewis RJ, Singh OM, Smith CV, Maxwell A, Skarzynski T, Wonacott AJ, Wigley DB. Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein. Journal of Molecular Biology. 241: 128-30. PMID 8051702 DOI: 10.1006/Jmbi.1994.1480 |
0.363 |
|
| 1994 |
Blandamer MJ, Briggs B, Cullis PM, Jackson AP, Maxwell A, Reece RJ. Domain structure of Escherichia coli DNA gyrase as revealed by differential scanning calorimetry. Biochemistry. 33: 7510-6. PMID 8011616 DOI: 10.1021/BI00190A003 |
0.381 |
|
| 1994 |
Thornton M, Armitage M, Maxwell A, Dosanjh B, Howells AJ, Norris V, Sigee DC. Immunogold localization of GyrA and GyrB proteins in Escherichia coli. Microbiology. 140: 2371-2382. PMID 7952188 DOI: 10.1099/13500872-140-9-2371 |
0.401 |
|
| 1994 |
Willmott CJ, Critchlow SE, Eperon IC, Maxwell A. The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase. Journal of Molecular Biology. 242: 351-63. PMID 7932695 DOI: 10.1006/Jmbi.1994.1586 |
0.496 |
|
| 1994 |
Orphanides G, Maxwell A. Topoisomerases: In one gate, out the other Current Biology. 4: 1006-1009. PMID 7874480 DOI: 10.1016/S0960-9822(00)00227-X |
0.578 |
|
| 1993 |
McCullough JE, Muller MT, Howells AJ, Maxwell A, O'Sullivan J, Summerill RS, Parker WL, Wells JS, Bonner DP, Fernandes PB. Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase. The Journal of Antibiotics. 46: 526-30. PMID 8386713 DOI: 10.7164/ANTIBIOTICS.46.526 |
0.46 |
|
| 1993 |
Ali JA, Jackson AP, Howells AJ, Maxwell A. The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs. Biochemistry. 32: 2717-24. PMID 8383523 DOI: 10.1021/Bi00061A033 |
0.638 |
|
| 1993 |
Willmott CJ, Maxwell A. A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex. Antimicrobial Agents and Chemotherapy. 37: 126-7. PMID 8381633 DOI: 10.1128/Aac.37.1.126 |
0.585 |
|
| 1993 |
Jackson AP, Maxwell A. Identifying the catalytic residue of the ATPase reaction of DNA gyrase. Proceedings of the National Academy of Sciences of the United States of America. 90: 11232-6. PMID 8248233 DOI: 10.1073/Pnas.90.23.11232 |
0.636 |
|
| 1993 |
Maxwell A. The interaction between coumarin drugs and DNA gyrase. Molecular Microbiology. 9: 681-686. PMID 8231802 DOI: 10.1111/J.1365-2958.1993.Tb01728.X |
0.542 |
|
| 1992 |
Cullis PM, Maxwell A, Weiner DP. Energy coupling in DNA gyrase: a thermodynamic limit to the extent of DNA supercoiling. Biochemistry. 31: 9642-9646. PMID 1327123 DOI: 10.1021/Bi00155A017 |
0.434 |
|
| 1992 |
Confreres A, Maxwell A. gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase. Molecular Microbiology. 6: 1617-1624. PMID 1323022 DOI: 10.1111/J.1365-2958.1992.Tb00886.X |
0.575 |
|
| 1992 |
Dobbs ST, Cullis PM, Maxwell A. The cleavage of DNA at phosphorothioate internucleotidic linkages by DNA gyrase. Nucleic Acids Research. 20: 3567-73. PMID 1322526 DOI: 10.1093/NAR/20.14.3567 |
0.445 |
|
| 1991 |
Reece RJ, Maxwell A. The C-terminal domain of the Escherichia coli DNA gyrase A subunit is a DNA-binding protein Nucleic Acids Research. 19: 1399-1405. PMID 1851291 DOI: 10.1093/Nar/19.7.1399 |
0.604 |
|
| 1991 |
Hallett P, Maxwell A. Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins. Antimicrobial Agents and Chemotherapy. 35: 335-340. PMID 1850970 DOI: 10.1128/Aac.35.2.335 |
0.556 |
|
| 1991 |
Jackson AP, Maxwell A, Wigley DB. Preliminary crystallographic analysis of the ATP-hydrolysing domain of the Escherichia coli DNA gyrase B protein. Journal of Molecular Biology. 217: 15-7. PMID 1846427 DOI: 10.1016/0022-2836(91)90606-7 |
0.521 |
|
| 1991 |
Reece RJ, Maxwell A. DNA Gyrase: Structure and Function Critical Reviews in Biochemistry and Molecular Biology. 26: 335-375. PMID 1657531 DOI: 10.3109/10409239109114072 |
0.614 |
|
| 1991 |
Wigley DB, Davies GJ, Dodson EJ, Maxwell A, Dodson G. Crystal structure of an N-terminal fragment of the DNA gyrase B protein. Nature. 351: 624-9. PMID 1646964 DOI: 10.1038/351624A0 |
0.507 |
|
| 1991 |
Reece RJ, Maxwell A. Probing the limits of the DNA breakage-reunion domain of the Escherichia coli DNA gyrase A protein Journal of Biological Chemistry. 266: 3540-3546. DOI: 10.1016/s0021-9258(19)67829-4 |
0.509 |
|
| 1990 |
Reece RJ, Dauter Z, Wilson KS, Maxwell A, Wigley DB. Preliminary crystallographic analysis of the breakage-reunion domain of the Escherichia coli DNA gyrase A protein. Journal of Molecular Biology. 215: 493-5. PMID 2172550 DOI: 10.1016/S0022-2836(05)80162-7 |
0.377 |
|
| 1990 |
Hallett P, Grimshaw AJ, Wigley DB, Maxwell A. Cloning of the DNA gyrase genes under tac promoter control: overproduction of the gyrase A and B proteins. Gene. 93: 139-142. PMID 2172086 DOI: 10.1016/0378-1119(90)90148-K |
0.418 |
|
| 1990 |
Krueger S, Zaccai G, Wlodawer A, Langowski J, O'Dea M, Maxwell A, Gellert M. Neutron and light-scattering studies of DNA gyrase and its complex with DNA. Journal of Molecular Biology. 211: 211-20. PMID 2153834 DOI: 10.1016/0022-2836(90)90021-D |
0.529 |
|
| 1990 |
Hallett P, Mehlert A, Maxwell A. Escherichia coli cells resistant to the DNA gyrase inhibitor, ciprofloxacin, overproduce a 60 kD protein homologous to GroEL. Molecular Microbiology. 4: 345-353. PMID 1972534 DOI: 10.1111/J.1365-2958.1990.Tb00602.X |
0.504 |
|
| 1989 |
Reece RJ, Maxwell A. Tryptic Fragments of the Escherichia coli DNA Gyrase A Protein Journal of Biological Chemistry. 264: 19648-19653. DOI: 10.1016/s0021-9258(19)47162-7 |
0.481 |
|
| 1989 |
Bates AD, Maxwell A. DNA gyrase can supercoil DNA circles as small as 174 base pairs. The Embo Journal. 8: 1861-1866. DOI: 10.1002/J.1460-2075.1989.Tb03582.X |
0.573 |
|
| 1988 |
Westerhoff HV, O'Dea MH, Maxwell A, Gellert M. DNA supercoiling by DNA gyrase. A static head analysis. Cell Biophysics. 12: 157-81. PMID 2453279 DOI: 10.1007/BF02918357 |
0.451 |
|
| 1987 |
Rau DC, Gellert M, Thoma F, Maxwell A. Structure of the DNA gyrase-DNA complex as revealed by transient electric dichroism Journal of Molecular Biology. 193: 555-569. PMID 3035196 DOI: 10.1016/0022-2836(87)90266-X |
0.6 |
|
| 1987 |
Chen Y, Maxwell A, Westerhoff HV. Co-operativity and enzymatic activity in polymer-activated enzymes. A one-dimensional piggy-back binding model and its application to the DNA-dependent ATPase of DNA gyrase. Journal of Molecular Biology. 190: 201-14. PMID 3025451 DOI: 10.1016/0022-2836(86)90293-7 |
0.512 |
|
| 1987 |
Maxwell A, Craigie R, Mizuuchi K. B protein of bacteriophage mu is an ATPase that preferentially stimulates intermolecular DNA strand transfer. Proceedings of the National Academy of Sciences of the United States of America. 84: 699-703. PMID 2949325 DOI: 10.1073/Pnas.84.3.699 |
0.524 |
|
| 1986 |
Wijmenga SS, Maxwell A. Rotational diffusion of short DNA fragments in polyacrylamide gels: an electric birefringence study. Biopolymers. 25: 2173-2186. PMID 3790705 DOI: 10.1002/Bip.360251110 |
0.415 |
|
| 1986 |
Maxwell A, Gellert M. Mechanistic Aspects of DNA Topoisomerases Advances in Protein Chemistry. 38: 69-107. PMID 3026152 DOI: 10.1016/S0065-3233(08)60526-4 |
0.611 |
|
| 1984 |
Maxwell A, Gellert M. The DNA dependence of the ATPase activity of DNA gyrase. Journal of Biological Chemistry. 259: 14472-14480. DOI: 10.1016/s0021-9258(17)42623-8 |
0.522 |
|
| 1982 |
Maxwell A, Halford SE. The SalGI restriction endonuclease. Enzyme specificity. Biochemical Journal. 203: 93-98. PMID 6285900 DOI: 10.1042/Bj2030093 |
0.726 |
|
| 1982 |
Maxwell A, Halford SE. The SalGI restriction endonuclease. Mechanism of DNA cleavage Biochemical Journal. 203: 85-92. PMID 6285899 DOI: 10.1042/Bj2030085 |
0.743 |
|
| 1982 |
Maxwell A, Halford SE. The SalGI restriction endonuclease. Purification and properties Biochemical Journal. 203: 77-84. PMID 6285898 DOI: 10.1042/Bj2030077 |
0.609 |
|
| 1981 |
Maxwell A, Halford SE. The Mechanism Of Dna Cleavage By Restriction Endonuclease Salgi Biochemical Society Transactions. 9. DOI: 10.1042/Bst009227Pc |
0.737 |
|
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