Hao Fang - Publications

Affiliations: 
Georgia State University, Atlanta, GA, United States 

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ma M, Yang Y, Chen Z, Li X, Yang Z, Wang K, Li X, Fang H, Cheng Y, Qiao T, Zou X, Lu Z, Wang X, Wu D. T-cell senescence induced by peripheral phospholipids. Cell Biology and Toxicology. PMID 37261679 DOI: 10.1007/s10565-023-09811-y  0.453
2021 Liang T, Xue J, Yao Z, Ye Y, Yang X, Hou X, Fang H. Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors. European Journal of Medicinal Chemistry. 221: 113526. PMID 33992929 DOI: 10.1016/j.ejmech.2021.113526  0.302
2020 Liang X, Fu H, Xiao P, Fang H, Hou X. Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors. Bioorganic Chemistry. 103: 104124. PMID 32768742 DOI: 10.1016/J.Bioorg.2020.104124  0.38
2020 Du J, Li W, Liu B, Zhang Y, Yu J, Hou X, Fang H. An in silico mechanistic insight into HDAC8 activation facilitates the discovery of new small-molecule activators. Bioorganic & Medicinal Chemistry. 28: 115607. PMID 32690262 DOI: 10.1016/J.Bmc.2020.115607  0.338
2020 Du J, Liu L, Liu B, Yang J, Hou X, Yu J, Fang H. Structure-based virtual screening, biological evaluation and biophysical study of novel Mcl-1 inhibitors. Future Medicinal Chemistry. PMID 32397829 DOI: 10.4155/Fmc-2020-0114  0.423
2020 Zhou Y, Liu X, Xue J, Liu L, Liang T, Li W, Yang X, Hou X, Fang H. Discovery of Peptide Boronate Derivatives as Histone Deacetylase (HDAC) and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma. Journal of Medicinal Chemistry. PMID 32267687 DOI: 10.1021/Acs.Jmedchem.9B02161  0.33
2020 Liu L, Liu R, Yang X, Hou X, Fang H. Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. European Journal of Medicinal Chemistry. 191: 112142. PMID 32088497 DOI: 10.1016/J.Ejmech.2020.112142  0.39
2020 Hou X, Sun JP, Ge L, Liang X, Li K, Zhang Y, Fang H. Inhibition of striatal-enriched protein tyrosine phosphatase by targeting computationally revealed cryptic pockets. European Journal of Medicinal Chemistry. 190: 112131. PMID 32078861 DOI: 10.1016/J.Ejmech.2020.112131  0.355
2020 Du J, Guo J, Kang D, Li Z, Wang G, Wu J, Zhang Z, Fang H, Hou X, Huang Z, Li G, Lu X, Liu X, Ouyang L, Rao L, et al. New techniques and strategies in drug discovery Chinese Chemical Letters. 31: 1695-1708. DOI: 10.1016/J.Cclet.2020.03.028  0.374
2019 Chen C, Yang X, Fang H, Hou X. Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors. European Journal of Medicinal Chemistry. 181: 111563. PMID 31415980 DOI: 10.1016/J.Ejmech.2019.111563  0.319
2019 Liang T, Hou X, Zhou Y, Yang X, Fang H. Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors. Acs Medicinal Chemistry Letters. 10: 1122-1127. PMID 31413795 DOI: 10.1021/Acsmedchemlett.9B00084  0.407
2019 Chen C, Nie Y, Xu G, Yang X, Fang H, Hou X. Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry. PMID 31079964 DOI: 10.1016/J.Bmc.2019.05.003  0.361
2019 Liu R, Liu L, Yang X, Fang H. Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors. Bioorganic Chemistry. 88: 102938. PMID 31028992 DOI: 10.1016/J.Bioorg.2019.102938  0.412
2019 Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, et al. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. The Journal of Biological Chemistry. PMID 30979725 DOI: 10.1074/Jbc.Ra118.007129  0.391
2019 Liu T, Dong G, Xu F, Han B, Fang H, Huang Y, Zhou Y, Du L, Li M. Discovery of Turn-On Fluorescent Probes for Detecting Bcl-2 Protein. Analytical Chemistry. PMID 30859811 DOI: 10.1021/Acs.Analchem.8B05853  0.684
2019 Li Y, Fang H, Hou Z, Sang L, Yang X. An in-line capillary electrophoresis assay for the high-throughput screening of histone deacetylase inhibitors. Journal of Chromatography. A. PMID 30665742 DOI: 10.1016/J.Chroma.2019.01.025  0.329
2018 Hou X, Rooklin DW, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H. Computational strategy for bound state structure prediction in structure-based virtual screening: a case study of protein tyrosine phosphatase receptor type O inhibitors. Journal of Chemical Information and Modeling. PMID 30299094 DOI: 10.1021/Acs.Jcim.8B00548  0.34
2018 Liu R, Liu L, Liu T, Yang X, Wan Y, Fang H. Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors. Bioorganic & Medicinal Chemistry. PMID 30170927 DOI: 10.1016/J.Bmc.2018.08.030  0.369
2018 Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A, Yu X, et al. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. The Journal of Biological Chemistry. PMID 30154244 DOI: 10.1074/Jbc.Ra118.004175  0.331
2018 Wan Y, Dai N, Tang Z, Fang H. Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. European Journal of Medicinal Chemistry. 146: 471-482. PMID 29407973 DOI: 10.1016/J.Ejmech.2018.01.076  0.342
2018 Fang G, Wang H, Bian Z, Sun J, Liu A, Fang H, Liu B, Yao Q, Wu Z. Recent development of boronic acid-based fluorescent sensors Rsc Advances. 8: 29400-29427. DOI: 10.1039/C8Ra04503H  0.342
2017 Liu T, Jiang Y, Liu Z, Li J, Fang K, Zhuang C, Du L, Fang H, Sheng C, Li M. Correction: Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction. Medchemcomm. 8: 1727. PMID 30109865 DOI: 10.1039/C7Md90031G  0.66
2017 Liu T, Jiang Y, Liu Z, Li J, Fang K, Zhuang C, Du L, Fang H, Sheng C, Li M. Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction. Medchemcomm. 8: 1668-1672. PMID 30108877 DOI: 10.1039/C7Md00287D  0.686
2017 Liu T, Gao Y, Zhang X, Wan Y, Du L, Fang H, Li M. Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 (Mcl-1) Protein. Analytical Chemistry. PMID 29025262 DOI: 10.1021/Acs.Analchem.7B01148  0.693
2017 Xu G, Liu T, Zhou Y, Yang X, Fang H. 1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation. Bioorganic & Medicinal Chemistry. PMID 28866374 DOI: 10.1016/J.Bmc.2017.08.024  0.4
2017 Zhou Y, Dun Y, Fu H, Wang L, Pan X, Yang X, Fang H. Design, synthesis and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase (HDAC) inhibitor. Chemical Biology & Drug Design. PMID 28489276 DOI: 10.1111/Cbdd.13019  0.407
2017 Chen C, Hou X, Wang G, Pan W, Yang X, Zhang Y, Fang H. Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors. European Journal of Medicinal Chemistry. 133: 11-23. PMID 28371677 DOI: 10.1016/J.Ejmech.2017.03.064  0.395
2017 Liu T, Wan Y, Liu R, Ma L, Li M, Fang H. Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry. PMID 28233676 DOI: 10.1016/J.Bmc.2017.02.014  0.611
2016 Hou X, Rooklin D, Fang H, Zhang Y. Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation. Scientific Reports. 6: 38186. PMID 27901083 DOI: 10.1038/Srep38186  0.328
2016 Wan Y, Liu T, Li X, Chen C, Fang H. Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains. Bioorganic & Medicinal Chemistry. PMID 27810438 DOI: 10.1016/J.Bmc.2016.10.020  0.427
2016 Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ, Fang H, Sun JP. Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorganic & Medicinal Chemistry Letters. PMID 27554446 DOI: 10.1016/J.Bmcl.2016.08.024  0.393
2016 Liu R, Wang J, Tang W, Fang H. Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry. PMID 26907204 DOI: 10.1016/J.Bmc.2016.02.005  0.418
2016 Pan X, Wang L, Dun Y, Fang H. Synthesis and Antiproliferative Activity Studies on 2-Substitued Aniline Quinazoline Derivatives Chinese Journal of Organic Chemistry. 36: 1044. DOI: 10.6023/Cjoc201510018  0.346
2016 Liu T, Wan Y, Liu R, Ma L, Li M, Fang H. Improved antiproliferative activities of a new series of 1,3,4-thiadiazole derivatives against human leukemia and breast cancer cell lines Chemical Research in Chinese Universities. 32: 768-774. DOI: 10.1007/S40242-016-6159-6  0.571
2015 Wan Y, Wang J, Sun F, Chen M, Hou X, Fang H. Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors. Bioorganic & Medicinal Chemistry. PMID 26620718 DOI: 10.1016/J.Bmc.2015.11.014  0.409
2015 Wang G, Wang Y, Wang L, Han L, Hou X, Fu H, Fang H. Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. Bioorganic & Medicinal Chemistry. PMID 26558516 DOI: 10.1016/J.Bmc.2015.10.023  0.373
2015 Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. Chemmedchem. PMID 26553423 DOI: 10.1002/Cmdc.201500454  0.429
2015 Fu H, Hou X, Wang L, Dun Y, Yang X, Fang H. Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 26421995 DOI: 10.1016/J.Bmcl.2015.09.051  0.402
2015 Hou X, Li K, Yu X, Sun JP, Fang H. Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures. Journal of Chemical Information and Modeling. PMID 26360643 DOI: 10.1021/Acs.Jcim.5B00344  0.365
2015 Fu H, Han L, Hou X, Dun Y, Wang L, Gong X, Fang H. Design, synthesis and biological evaluation of saccharin-based N-hydroxybenzamides as histone deacetylases (HDACs) inhibitors. Bioorganic & Medicinal Chemistry. 23: 5774-81. PMID 26216016 DOI: 10.1016/J.Bmc.2015.07.008  0.362
2015 Wang L, Hou X, Fu H, Pan X, Xu W, Tang W, Fang H. Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors. Bioorganic & Medicinal Chemistry. PMID 26149591 DOI: 10.1016/J.Bmc.2015.06.024  0.432
2015 Wan Y, Wu S, Xiao G, Liu T, Hou X, Chen C, Guan P, Yang X, Fang H. Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. Bioorganic & Medicinal Chemistry. 23: 1994-2003. PMID 25818766 DOI: 10.1016/J.Bmc.2015.03.024  0.387
2015 Hou X, Du J, Liu R, Zhou Y, Li M, Xu W, Fang H. Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8. Journal of Chemical Information and Modeling. 55: 861-71. PMID 25757142 DOI: 10.1021/Ci500762Z  0.584
2014 Hou X, Li R, Li K, Yu X, Sun JP, Fang H. Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. Journal of Medicinal Chemistry. 57: 9309-22. PMID 25372368 DOI: 10.1021/Jm500692U  0.364
2014 Guan P, Wang L, Hou X, Wan Y, Xu W, Tang W, Fang H. Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif. Bioorganic & Medicinal Chemistry. 22: 5766-75. PMID 25311567 DOI: 10.1016/J.Bmc.2014.09.039  0.353
2014 Wan Y, Liu T, Hou X, Dun Y, Guan P, Fang H. Antagonists of IAP proteins: novel anti-tumor agents. Current Medicinal Chemistry. 21: 3877-92. PMID 25174926 DOI: 10.2174/0929867321666140826115258  0.315
2014 Yang X, Su L, Hou X, Ding S, Xu W, Wang B, Fang H. High-performance liquid chromatographic enantioseparation of 3,5-disubstituted hydantoins analogs and temperature-induced reversals of elution orders on a polysaccharide-based chiral stationary phase. Journal of Chromatography. A. 1355: 291-5. PMID 24973033 DOI: 10.1016/J.Chroma.2014.06.022  0.481
2014 Fu H, Fang H, Sun J, Wang H, Liu A, Sun J, Wu Z. Boronic acid-based enzyme inhibitors: a review of recent progress. Current Medicinal Chemistry. 21: 3271-80. PMID 24934348 DOI: 10.2174/0929867321666140601200803  0.339
2014 Han L, Wang L, Hou X, Fu H, Song W, Tang W, Fang H. Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry. 22: 1529-38. PMID 24525003 DOI: 10.1016/J.Bmc.2014.01.045  0.401
2014 Wang J, Wang Q, Dun Y, Fang H. Syntheses and Antitumor Activities of Purine-sulfonamides Derivatives† Chemical Journal of Chinese Universities-Chinese. 35: 1189. DOI: 10.7503/Cjcu20131048  0.323
2014 Wang J, Sun F, Han L, Hou X, Pan X, Liu R, Tang W, Fang H. Design, synthesis, and preliminary bioactivity studies of substituted purine hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors Medchemcomm. 5: 1887-1891. DOI: 10.1039/C4Md00203B  0.366
2013 Zhang Y, Inks ES, Zhu M, Chou CJ, Fang H, Li M, Shen Y, Yi F, Xu W. Discovery of a Pair of Diastereomers as Potent HDACs Inhibitors: Determination of Absolute Configuration, Biological Activity Comparison and Computational Study. Rsc Advances. 3. PMID 24273644 DOI: 10.1039/C3Ra43249A  0.567
2013 Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, et al. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Scientific Reports. 3: 2333. PMID 23903585 DOI: 10.1038/Srep02333  0.308
2013 Su L, Jia Y, Wang X, Zhang L, Fang H, Xu W. Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent. Bioorganic & Medicinal Chemistry Letters. 23: 2512-7. PMID 23528299 DOI: 10.1016/J.Bmcl.2013.03.021  0.359
2013 Hou X, Du J, Zhang J, Du L, Fang H, Li M. How to improve docking accuracy of AutoDock4.2: a case study using different electrostatic potentials. Journal of Chemical Information and Modeling. 53: 188-200. PMID 23244516 DOI: 10.1021/Ci300417Y  0.66
2013 Chen L, Sun W, Li J, Liu Z, Ma Z, Zhang W, Du L, Xu W, Fang H, Li M. The first ratiometric fluorescent probes for aminopeptidase N cell imaging. Organic & Biomolecular Chemistry. 11: 378-82. PMID 23174889 DOI: 10.1039/C2Ob26564H  0.681
2013 Zhang X, Zhang L, Zhang J, Feng J, Yuan Y, Fang H, Xu W. Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 545-51. PMID 22380779 DOI: 10.3109/14756366.2012.656622  0.387
2013 Chen L, Li J, Liu Z, Ma Z, Zhang W, Du L, Xu W, Fang H, Li M. A novel pH "off-on" fluorescent probe for lysosome imaging Rsc Advances. 3: 13412-13416. DOI: 10.1039/C3Ra41898G  0.542
2013 Wang J, Wang Q, Zhang L, Fang H. Design, Synthesis and Preliminary Biological Evaluation of Purine-2,6-diamine Derivatives as Cyclin-dependent Kinase (CDK) Inhibitors Chinese Journal of Chemistry. 31: 1181-1191. DOI: 10.1002/Cjoc.201300420  0.353
2012 Su L, Cao J, Jia Y, Zhang X, Fang H, Xu W. Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis. Acs Medicinal Chemistry Letters. 3: 959-64. PMID 24900417 DOI: 10.1021/Ml3000758  0.362
2012 Yang X, Hou X, Wang B, Li M, Fang H. Density functional theory based quantitative structure-property relationship studies on coumarin-based prodrugs. Bioscience Trends. 6: 234-40. PMID 23229116 DOI: 10.5582/Bst.2012.V6.5.234  0.628
2012 Wu Z, Li M, Fang H, Wang B. A new boronic acid based fluorescent reporter for catechol. Bioorganic & Medicinal Chemistry Letters. 22: 7179-82. PMID 23079526 DOI: 10.1016/J.Bmcl.2012.09.060  0.655
2012 Yao J, He Z, Chen J, Sun W, Fang H, Xu W. Design, synthesis and biological activities of sorafenib derivatives as antitumor agents. Bioorganic & Medicinal Chemistry Letters. 22: 6549-53. PMID 23021967 DOI: 10.1016/J.Bmcl.2012.09.031  0.391
2012 Sun W, Wu J, Li J, Fang H, Du L, Li M. Boronate can be the fluorogenic switch for the detection of hydrogen peroxide. Current Medicinal Chemistry. 19: 3622-34. PMID 22612709 DOI: 10.2174/092986712801323270  0.662
2012 Su L, Jia Y, Zhang L, Xu Y, Fang H, Xu W. Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 20: 3807-15. PMID 22607877 DOI: 10.1016/J.Bmc.2012.04.035  0.408
2012 Guan P, Sun F, Hou X, Wang F, Yi F, Xu W, Fang H. Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry. 20: 3865-72. PMID 22579621 DOI: 10.1016/J.Bmc.2012.04.032  0.414
2012 Huang S, Jia M, Xie Y, Wang J, Xu W, Fang H. The progress of selective fluorescent chemosensors by boronic acid. Current Medicinal Chemistry. 19: 2621-37. PMID 22506769 DOI: 10.2174/092986712800493066  0.337
2012 Li Q, Fang H, Wang X, Hu G, Wang Q, Xu W. Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 850-3. PMID 22206607 DOI: 10.1016/J.Bmcl.2011.12.048  0.401
2012 Zhang X, Fang H, Zhang J, Yuan Y, Xu W. Recent advance in aminopeptidase N (APN/CD13) inhibitor research. Current Medicinal Chemistry. 18: 5011-21. PMID 22050749 DOI: 10.2174/092986711797535155  0.339
2012 Yang K, Fen J, Fang H, Zhang L, Gong J, Xu W. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 27: 302-10. PMID 21770859 DOI: 10.3109/14756361003698147  0.398
2012 Wu Z, Yang X, Xu W, Wang B, Fang H. A new boronic acid-based fluorescent sensor for L-dihydroxyphenylalanine. Drug Discoveries and Therapeutics. 6: 238-241. DOI: 10.5582/Ddt.2012.V6.5.238  0.501
2012 Wu S, Chen M, Wang Y, Hou X, Yang X, Su L, Fang H. A facile method for the synthesis of N-(α-aminoacyl) sulfonamides. Drug Discoveries and Therapeutics. 6: 62-68. DOI: 10.5582/Ddt.2012.V6.2.62  0.313
2012 Chen L, Sun W, Li W, Li J, Du L, Xu W, Fang H, Li M. The first ratiometric fluorescent probe for aminopeptidase N Analytical Methods. 4: 2661-2663. DOI: 10.1039/C2Ay25556A  0.674
2012 Liu Y, Liu X, Sun W, Fang H, Li M, Xu W. Synthesis of tert-butyl 1-(5,8-dioxohexahydro-[1,3]thiazolo[3,4-a]pyrazin-3-yl)ethylcarbamate Chemistry of Heterocyclic Compounds. 48: 950-954. DOI: 10.1007/S10593-012-1082-3  0.515
2012 Yao J, Chen J, He Z, Sun W, Fang H, Xu W. Thiourea and thioether derivatives of sorafenib: synthesis, crystal structure, and antiproliferative activity Medicinal Chemistry Research. 22: 3959-3968. DOI: 10.1007/S00044-012-0400-8  0.373
2012 Xu Y, Zhang L, Li M, Xu W, Fang H, Shang L. QSAR studies of aminopeptidase N/CD13 (APN) inhibitors with the scaffold 3-phenylpropane-1,2-diamine and molecular docking Medicinal Chemistry Research. 21: 1000-1015. DOI: 10.1007/S00044-011-9597-1  0.585
2012 Zhang L, Li M, Feng J, Fang H, Xu W. Discovery of a novel histone deacetylase 8 inhibitor by virtual screening Medicinal Chemistry Research. 21: 152-156. DOI: 10.1007/S00044-010-9519-7  0.57
2011 Chen LZ, Mou JJ, Xu YY, Fang H, Xu WF. Design, synthesis and activity study of aminopeptidase N targeted 3-amino-2-hydroxy-4-phenyl-butanoic acid derivatives. Drug Discoveries & Therapeutics. 5: 61-5. PMID 22466141 DOI: 10.5582/Ddt.2011.V5.2.61  0.416
2011 Zhang Y, Feng J, Jia Y, Xu Y, Liu C, Fang H, Xu W. Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group. European Journal of Medicinal Chemistry. 46: 5387-97. PMID 21924799 DOI: 10.1016/J.Ejmech.2011.08.045  0.383
2011 Zhang X, Zhang J, Zhang L, Feng J, Xu Y, Yuan Y, Fang H, Xu W. Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 19: 6015-25. PMID 21911297 DOI: 10.1016/J.Bmc.2011.08.041  0.409
2011 Jia M, Yang K, Fang H, Xu Y, Sun S, Su L, Xu W. Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine. Bioorganic & Medicinal Chemistry. 19: 5190-8. PMID 21802307 DOI: 10.1016/J.Bmc.2011.07.008  0.404
2011 Zhang Y, Feng J, Liu C, Fang H, Xu W. Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors. Bioorganic & Medicinal Chemistry. 19: 4437-44. PMID 21733698 DOI: 10.1016/J.Bmc.2011.06.046  0.397
2011 Zhang Y, Fang H, Feng J, Jia Y, Wang X, Xu W. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. Journal of Medicinal Chemistry. 54: 5532-9. PMID 21714538 DOI: 10.1021/Jm200577A  0.379
2011 Wang Q, Su L, Liu N, Zhang L, Xu W, Fang H. Cyclin dependent kinase 1 inhibitors: a review of recent progress. Current Medicinal Chemistry. 18: 2025-43. PMID 21517772 DOI: 10.2174/092986711795590110  0.307
2011 Zhang Y, Feng J, Jia Y, Wang X, Zhang L, Liu C, Fang H, Xu W. Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities. Journal of Medicinal Chemistry. 54: 2823-38. PMID 21476600 DOI: 10.1021/Jm101605Z  0.431
2011 Liu Y, Jing F, Xu Y, Xie Y, Shi F, Fang H, Li M, Xu W. Design, synthesis and biological activity of thiazolidine-4-carboxylic acid derivatives as novel influenza neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 19: 2342-8. PMID 21382719 DOI: 10.1016/J.Bmc.2011.02.019  0.601
2011 Xie Y, Gong J, Li M, Fang H, Xu W. The medicinal potential of influenza virus surface proteins: Hemagglutinin and neuraminidase Current Medicinal Chemistry. 18: 1050-1066. PMID 21254972 DOI: 10.2174/092986711794940815  0.522
2011 Luan Y, Ma C, Sui Z, Wang X, Feng J, Liu N, Jing F, Wang Y, Li M, Fang H, Xu W. LYP3, a new bestatin derivative for aminopeptidase N inhibition. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 7: 32-6. PMID 21235517 DOI: 10.2174/157340611794072706  0.555
2011 Su L, Fang H, Yang K, Xu Y, Xu W. Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors. Bioorganic & Medicinal Chemistry. 19: 900-6. PMID 21194957 DOI: 10.1016/J.Bmc.2010.11.066  0.389
2011 Zhang L, Tsai KC, Du L, Fang H, Li M, Xu W. How to generate reliable and predictive CoMFA models Current Medicinal Chemistry. 18: 923-930. PMID 21182474 DOI: 10.2174/092986711794927702  0.65
2011 Hou X, Du J, Fang H, Li M. 3D-QSAR study on a series of bcl-2 protein inhibitors using comparative molecular field analysis Protein and Peptide Letters. 18: 440-449. PMID 21171944 DOI: 10.2174/092986611794927992  0.543
2011 Liu Y, Zhang L, Gong J, Fang H, Liu A, Du G, Xu W. Design, synthesis, and biological activity of thiazole derivatives as novel influenza neuraminidase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 26: 506-13. PMID 21143042 DOI: 10.3109/14756366.2010.534732  0.386
2011 Luan Y, Wang Q, Liu N, Mou J, Jiao X, Fang H, Li M, Xu W. Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor Anti-Cancer Drugs. 22: 99-103. PMID 21048494 DOI: 10.1097/Cad.0B013E32833Ab78A  0.573
2011 Wang X, Zhang L, Yang K, Zhang C, Zhang J, Fang H, Xu W. The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor. Biological & Pharmaceutical Bulletin. 33: 1658-65. PMID 20930372 DOI: 10.1248/Bpb.33.1658  0.346
2011 Wang X, Jing F, Zhu H, Fang H, Zhang J, Xu W. Activity screening and structure-activity relationship of the hit compounds targeting APN/CD13. Fundamental & Clinical Pharmacology. 25: 217-28. PMID 20636366 DOI: 10.1111/J.1472-8206.2010.00844.X  0.38
2011 Zhang L, Zhu H, Wang Q, Fang H, Xu W, Li M. Homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1 Journal of Molecular Modeling. 17: 219-226. PMID 20419498 DOI: 10.1007/S00894-010-0710-Z  0.537
2010 Cheng Y, Li M, Wang S, Peng H, Reid S, Ni N, Fang H, Xu W, Wang B. Carbohydrate biomarkers for future disease detection and treatment. Science China. Chemistry. 53: 3-20. PMID 32214994 DOI: 10.1007/S11426-010-0021-3  0.739
2010 Zhang Y, Fang H, Xu W. Applications and modifications of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in peptides and peptidomimetics design and discovery. Current Protein & Peptide Science. 11: 752-8. PMID 21235510 DOI: 10.2174/138920310794557691  0.329
2010 Cao J, Fang H, Wang B, Ma C, Xu W. Epidermal growth factor receptor as a target for anti-cancer agent design. Anti-Cancer Agents in Medicinal Chemistry. 10: 491-503. PMID 20698825 DOI: 10.2174/1871520611009060491  0.487
2010 Zhang X, Fang H, Zhu H, Wang X, Zhang L, Li M, Li Q, Yuan Y, Xu W. Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N′-substituted-2,6-piperidinedione Bioorganic and Medicinal Chemistry. 18: 5981-5987. PMID 20637634 DOI: 10.1016/J.Bmc.2010.06.078  0.584
2010 Zhang Y, Feng J, Liu C, Zhang L, Jiao J, Fang H, Su L, Zhang X, Zhang J, Li M, Wang B, Xu W. Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors. Bioorganic & Medicinal Chemistry. 18: 1761-72. PMID 20171895 DOI: 10.1016/J.Bmc.2010.01.060  0.675
2010 Wang Q, Xu F, Mou J, Zhang J, Shang L, Luan Y, Yuan Y, Liu Y, Li M, Fang H, Wang B, Xu W. Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors. Protein and Peptide Letters. 17: 847-53. PMID 20156182 DOI: 10.2174/092986610791306661  0.656
2010 Li Q, Fang H, Wang X, Xu W. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II. European Journal of Medicinal Chemistry. 45: 1618-26. PMID 20129718 DOI: 10.1016/J.Ejmech.2009.12.071  0.429
2010 Mou J, Fang H, Liu Y, Shang L, Wang Q, Zhang L, Xu W. Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 18: 887-95. PMID 19969464 DOI: 10.1016/J.Bmc.2009.11.036  0.371
2010 Zhang L, Fang H, Xu W. Strategies in developing promising histone deacetylase inhibitors. Medicinal Research Reviews. 30: 585-602. PMID 19634125 DOI: 10.1002/Med.20169  0.347
2010 Jiao J, Fang H, Wang X, Zhu H, Jiang L, Xu W. Synthesis of a novel series of benzylether-containing cinnamoyl derivatives as histone deacetylase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 25: 132-8. PMID 19558346 DOI: 10.3109/14756360903049034  0.384
2009 Liu N, Fang H, Li Y, Xu W. Recent research in selective cyclin-dependent kinase 4 inhibitors for anti-cancer treatment. Current Medicinal Chemistry. 16: 4869-88. PMID 19929781 DOI: 10.2174/092986709789909611  0.312
2009 Liu Y, Shang L, Fang H, Zhu H, Mu J, Wang Q, Wang X, Yuan Y, Xu W. Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorganic & Medicinal Chemistry. 17: 7398-404. PMID 19782572 DOI: 10.1016/J.Bmc.2009.07.014  0.408
2009 Gong J, Fang H, Li M, Liu Y, Yang K, Xu W. Potential targets and their relevant inhibitors in anti-influenza fields Current Medicinal Chemistry. 16: 3716-3739. PMID 19747144 DOI: 10.2174/092986709789104984  0.519
2009 Li Q, Fang H, Wang X, Hu L, Xu W. Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I. European Journal of Medicinal Chemistry. 44: 4819-25. PMID 19683842 DOI: 10.1016/J.Ejmech.2009.07.022  0.42
2009 Jiao J, Fang H, Wang X, Guan P, Yuan Y, Xu W. Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors. European Journal of Medicinal Chemistry. 44: 4470-6. PMID 19608304 DOI: 10.1016/J.Ejmech.2009.06.010  0.387
2009 Mou J, Fang H, Jing F, Wang Q, Liu Y, Zhu H, Shang L, Wang X, Xu W. Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 17: 4666-73. PMID 19454370 DOI: 10.1016/J.Bmc.2009.04.056  0.399
2009 Yang K, Wang Q, Su L, Fang H, Wang X, Gong J, Wang B, Xu W. Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors. Bioorganic & Medicinal Chemistry. 17: 3810-7. PMID 19423354 DOI: 10.1016/J.Bmc.2009.04.038  0.564
2009 Shang L, Fang H, Zhu H, Wang X, Wang Q, Mu J, Wang B, Kishioka S, Xu W. Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 17: 2775-84. PMID 19299146 DOI: 10.1016/J.Bmc.2009.02.034  0.567
2009 Luan Y, Wang X, Zhu H, Qu X, Fang H, Xu W. The Synthesis and Activity Evaluation of a Bestatin Derivative (LYP) as an Aminopeptidase N Inhibitor Letters in Drug Design & Discovery. 6: 420-423. DOI: 10.2174/157018009789057535  0.333
2009 Zhu H, Fang H, Cheng X, Wang Q, Zhang L, Feng J, Xu W. 3D-QSAR study of pyrrolidine derivatives as matrix metalloproteinase-2 inhibitors Medicinal Chemistry Research. 18: 683-701. DOI: 10.1007/S00044-008-9160-X  0.323
2008 Shang L, Wang Q, Fang H, Mu J, Wang X, Yuan Y, Wang B, Xu W. Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry. 16: 9984-90. PMID 18996018 DOI: 10.1016/J.Bmc.2008.10.025  0.559
2008 Li M, Lin N, Huang Z, Du L, Altier C, Fang H, Wang B. Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety. Journal of the American Chemical Society. 130: 12636-8. PMID 18763762 DOI: 10.1021/Ja801510D  0.743
2008 Cheng XC, Wang Q, Fang H, Tang W, Xu WF. Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors. Bioorganic & Medicinal Chemistry. 16: 7932-8. PMID 18718763 DOI: 10.1016/J.Bmc.2008.07.073  0.327
2008 Li M, Fang H, Du L, Xia L, Wang B. Computational studies of the binding site of alpha1A-adrenoceptor antagonists. Journal of Molecular Modeling. 14: 957-66. PMID 18626669 DOI: 10.1007/S00894-008-0342-8  0.709
2008 Wang Q, Chen M, Zhu H, Zhang J, Fang H, Wang B, Xu W. Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 16: 5473-81. PMID 18467109 DOI: 10.1016/J.Bmc.2008.04.012  0.565
2008 Cheng XC, Wang Q, Fang H, Tang W, Xu WF. Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors. Bioorganic & Medicinal Chemistry. 16: 5398-404. PMID 18440232 DOI: 10.1016/J.Bmc.2008.04.027  0.346
2008 Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 16: 3839-47. PMID 18304821 DOI: 10.1016/J.Bmc.2008.01.036  0.387
2008 Xu W, Cheng X, Wang Q, Fang H. Advances in Matrix Metalloproteinase Inhibitors Based on Pyrrolidine Scaffold Current Medicinal Chemistry. 15: 374-385. DOI: 10.2174/092986708783497373  0.315
2008 Jiao J, Wang Q, Zhu HW, Fang H, Xu WF. Synthesis and biological evaluation of a new series of histone deacetylases inhibitors Chinese Chemical Letters. 19: 673-675. DOI: 10.1016/J.Cclet.2008.04.010  0.408
2008 Li YL, Fang H, Xu WF, Wang BH. New synthetic way to prepare 2-aryl-8-(piperidin-4-yl)-5,7-dimethoxy-4H-chromen-4-one as key intermediate for CDK inhibitor Chinese Chemical Letters. 19: 541-543. DOI: 10.1016/J.Cclet.2008.03.025  0.494
2007 Cheng XC, Wang Q, Fang H, Tang W, Xu WF. Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors. European Journal of Medicinal Chemistry. 43: 2130-9. PMID 18362041 DOI: 10.1016/J.Ejmech.2007.12.020  0.337
2007 Liu FZ, Fang H, Zhu HW, Wang Q, Yang Y, Xu WF. Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors. Bioorganic & Medicinal Chemistry. 16: 578-85. PMID 17937988 DOI: 10.1016/J.Bmc.2007.04.030  0.392
2007 Li Q, Fang H, Xu W. Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 2935-8. PMID 17433673 DOI: 10.1016/J.Bmcl.2006.12.095  0.366
2007 Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 15: 2749-58. PMID 17287121 DOI: 10.1016/J.Bmc.2007.01.020  0.376
2007 Lin N, Yan J, Huang Z, Altier C, Li M, Carrasco N, Suyemoto M, Johnston L, Wang S, Wang Q, Fang H, Caton-Williams J, Wang B. Design and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation into DNA. Nucleic Acids Research. 35: 1222-9. PMID 17267413 DOI: 10.1093/Nar/Gkl1091  0.67
2007 Liu FZ, Fang H, Xu WF. An efficient way to coupling amine with derivatives of steric N-Boc-pyrrolidine-2-carboxylic acid Chinese Chemical Letters. 18: 393-396. DOI: 10.1016/J.Cclet.2007.01.048  0.313
2007 Fang H, Li MY, Xia L. Pharmacophore-guided design, synthesis and evaluation of quinazoline-arylpiperazines as new α1-adrenoceptor antagonists Chinese Chemical Letters. 18: 41-44. DOI: 10.1016/J.Cclet.2006.11.022  0.343
2006 Zhang L, Zhang J, Fang H, Wang Q, Xu W. Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors. Bioorganic & Medicinal Chemistry. 14: 8286-94. PMID 17008101 DOI: 10.1016/J.Bmc.2006.09.015  0.383
2005 Yan J, Fang H, Wang B. Boronolectins and fluorescent boronolectins: an examination of the detailed chemistry issues important for the design. Medicinal Research Reviews. 25: 490-520. PMID 16025498 DOI: 10.1002/Med.20038  0.594
2005 Li MY, Fang H, Xia L. Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as alpha(1)-adrenoceptor antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 3216-9. PMID 15935663 DOI: 10.1016/J.Bmcl.2005.05.003  0.547
2005 Fang H, Kaur G, Yan J, Wang B. An Efficient Synthesis of Sterically Hindered Arylboronic Acids. Cheminform. 36. DOI: 10.1016/J.Tetlet.2005.01.064  0.504
2005 Fang H, Kaur G, Yan J, Wang B. An efficient synthesis of sterically hindered arylboronic acids Tetrahedron Letters. 46: 1671-1674. DOI: 10.1016/j.tetlet.2005.01.064  0.411
2004 Fang H, Yan J, Wang B. Biaryl product formation from cross-coupling in palladium-catalyzed borylation of a Boc protected aminobromoquinoline compound. Molecules (Basel, Switzerland). 9: 178-84. PMID 18007422 DOI: 10.3390/90300178  0.489
2004 Fang H, Kaur G, Wang B. Progress in boronic acid-based fluorescent glucose sensors. Journal of Fluorescence. 14: 481-9. PMID 15617256 DOI: 10.1023/B:Jofl.0000039336.51399.3B  0.514
2004 Ni W, Fang H, Springsteen G, Wang B. The design of boronic acid spectroscopic reporter compounds by taking advantage of the pK(a)-lowering effect of diol binding: nitrophenol-based color reporters for diols. The Journal of Organic Chemistry. 69: 1999-2007. PMID 15058946 DOI: 10.1021/Jo0350357  0.753
2003 Yang W, Yan J, Fang H, Wang B. The first fluorescent sensor for D-glucarate based on the cooperative action of boronic acid and guanidinium groups. Chemical Communications (Cambridge, England). 792-3. PMID 12703826 DOI: 10.1039/B300098B  0.681
Show low-probability matches.