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Juan Du, Ph.D. - Publications

Affiliations: 
2017- Van Andel Institute 
Area:
structural biology, neuroscience
Website:
https://dulab.vai.org
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ruan Z, Lee J, Li Y, Du J, Lü W. Human Pannexin 1 Channel is NOT Phosphorylated by Src Tyrosine Kinase at Tyr199 and Tyr309. Biorxiv : the Preprint Server For Biology. PMID 38168229 DOI: 10.1101/2023.09.10.557063  0.608
2023 Huang Y, Lü W, Du J. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. Biorxiv : the Preprint Server For Biology. PMID 36993210 DOI: 10.1101/2023.03.16.533055  0.815
2022 Bai S, Wei Y, Liu R, Chen Y, Ma W, Wang M, Chen L, Luo Y, Du J. The role of transient receptor potential channels in metastasis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 158: 114074. PMID 36493698 DOI: 10.1016/j.biopha.2022.114074  0.338
2022 Müller C, Zhang L, Zipfel S, Topitsch A, Lutz M, Eckert J, Prasser B, Chami M, Lü W, Du J, Einsle O. Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature. PMID 35896743 DOI: 10.1038/s41586-022-05015-2  0.59
2022 Tian PF, Sun MM, Hu XY, Du J, He W. TRPP2 ion channels: The roles in various subcellular locations. Biochimie. PMID 35760123 DOI: 10.1016/j.biochi.2022.06.010  0.416
2021 Ruan Z, Haley E, Orozco IJ, Sabat M, Myers R, Roth R, Du J, Lü W. Author Correction: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nature Structural & Molecular Biology. PMID 34285419 DOI: 10.1038/s41594-021-00641-2  0.777
2021 Ruan Z, Haley E, Orozco IJ, Sabat M, Myers R, Roth R, Du J, Lü W. Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nature Structural & Molecular Biology. PMID 34168372 DOI: 10.1038/s41594-021-00607-4  0.77
2021 Yu J, Zhu H, Lape R, Greiner T, Du J, Lü W, Sivilotti L, Gouaux E. Mechanism of gating and partial agonist action in the glycine receptor. Cell. PMID 33567265 DOI: 10.1016/j.cell.2021.01.026  0.639
2020 Ruan Z, Osei-Owusu J, Du J, Qiu Z, Lü W. Structures and pH-sensing mechanism of the proton-activated chloride channel. Nature. PMID 33149300 DOI: 10.1038/s41586-020-2875-7  0.66
2020 Ruan Z, Orozco IJ, Du J, Lü W. Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature. PMID 32494015 DOI: 10.1038/S41586-020-2357-Y  0.833
2020 Lü W, Du J. The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site. The Journal of General Physiology. 152. PMID 32282890 DOI: 10.1085/Jgp.201912555  0.543
2020 Csanády L, Du J, Zubcevic L. Decision letter: Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms Elife. DOI: 10.7554/Elife.58660.Sa1  0.477
2020 Huang Y, Roth B, Lu W, Du J. Ligand Recognition and Gating Mechanism of the TRPM2 Channel Biophysical Journal. 118: 22a. DOI: 10.1016/J.Bpj.2019.11.300  0.578
2019 Huang Y, Fliegert R, Guse AH, Lü W, Du J. A structural overview of the ion channels of the TRPM family. Cell Calcium. 85: 102111. PMID 31812825 DOI: 10.1016/J.Ceca.2019.102111  0.817
2019 Choi W, Clemente N, Sun W, Du J, Lü W. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature. PMID 31776515 DOI: 10.1038/S41586-019-1781-3  0.814
2019 Huang Y, Roth B, Lu W, Du J. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife. 8. PMID 31513012 DOI: 10.7554/Elife.50175  0.81
2019 Haley E, Choi W, Fan C, Sun W, Du J, Lü W. Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy. Journal of Visualized Experiments : Jove. PMID 30663716 DOI: 10.3791/58754  0.794
2019 Huang Y, Roth B, Lü W, Du J. Author response: Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel Elife. DOI: 10.7554/Elife.50175.029  0.521
2019 Haley E, Choi W, Fan C, Sun W, Du J, Lü W. Expression and purification of the human lipid-sensitive cation channel TRPC3 for structural determination by single-particle cryo-electron microscopy Jove.  0.349
2019 Huang Y, Roth B, Lü W#, Du J#. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel Elife.  0.355
2018 Huang Y, Winkler PA, Sun W, Lü W, Du J. Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature. PMID 30250252 DOI: 10.1038/S41586-018-0558-4  0.808
2018 Fan C, Choi W, Sun W, Du J, Lu W. Structure of the human lipid-gated cation channel TRPC3. Elife. 7. PMID 29726814 DOI: 10.7554/Elife.36852  0.805
2018 Fan C, Choi W, Sun W, Du J, Lü W. Author response: Structure of the human lipid-gated cation channel TRPC3 Elife. DOI: 10.7554/Elife.36852.021  0.581
2018 Fan C, Choi W, Sun W, Du J, Lu W. Structure of the human lipid-sensitive cation channel TRPC3 Elife. DOI: 10.2210/Pdb6Cud/Pdb  0.58
2018 Huang Y, Winkler PA, Sun W, Lü W, Du J. Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium Nature.  0.39
2018 Fan C*, Choi W*, Sun W, Du J#, Lü W#. Structure of the human lipid-gated cation channel TRPC3. Elife.  0.453
2017 Winkler PA, Huang Y, Sun W, Du J, Lü W. Electron cryo-microscopy structure of a human TRPM4 channel. Nature. 552: 200-204. PMID 29211723 DOI: 10.1038/Nature24674  0.815
2017 Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller MR, Tian J, Zhu J, Xu J, Wen M, Er-Bu A, Wang J, Xiao Y, Wu M, McManus OB, et al. Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. Journal of Medicinal Chemistry. PMID 28395140 DOI: 10.1021/Acs.Jmedchem.7B00304  0.399
2017 Lü W, Du J, Goehring A, Gouaux E. Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation. Science (New York, N.Y.). PMID 28232581 DOI: 10.1126/Science.Aal3729  0.505
2017 Winkler PA*, Huang Y*, Sun W*, Du J, Lü W. Electron cryo-microscopy structure of a human TRPM4 channel Nature.  0.405
2016 Du J, Fu J, Xia XM, Shen B. The functions of TRPP2 in the vascular system. Acta Pharmacologica Sinica. 37: 13-8. PMID 26725733 DOI: 10.1038/aps.2015.126  0.323
2015 Song K, Zhong XG, Xia XM, Huang JH, Fan YF, Yuan RX, Xue NR, Du J, Han WX, Xu AM, Shen B. Orai1 forms a signal complex with SK3 channel in gallbladder smooth muscle. Biochemical and Biophysical Research Communications. PMID 26367175 DOI: 10.1016/j.bbrc.2015.09.049  0.305
2015 Du J, Lü W, Wu S, Cheng Y, Gouaux E. Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature. PMID 26344198 DOI: 10.1038/Nature14853  0.524
2014 Yu Z, Li J, Zhu J, Zhu M, Jiang F, Zhang J, Li Z, Zhong M, Kaye JB, Du J, Shen B. A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential. Journal of Materials Chemistry. B. 2: 3809-3818. PMID 32261727 DOI: 10.1039/c3tb21645d  0.404
2014 Du J, Ma X, Shen B, Huang Y, Birnbaumer L, Yao X. TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4677-85. PMID 25114176 DOI: 10.1096/Fj.14-251652  0.446
2014 Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E. NMDA receptor structures reveal subunit arrangement and pore architecture. Nature. 511: 191-7. PMID 25008524 DOI: 10.1038/Nature13548  0.789
2013 Lü W, Du J, Schwarzer NJ, Wacker T, Andrade SL, Einsle O. The formate/nitrite transporter family of anion channels. Biological Chemistry. 394: 715-27. PMID 23380538 DOI: 10.1515/Hsz-2012-0339  0.7
2013 Lü W, Du J, Schwarzer N, Wacker T, Andrade SLA, Einsle O. The formate/nitrite transporter family of anion channels Biol Chem.  0.345
2012 Lü W, Schwarzer NJ, Du J, Gerbig-Smentek E, Andrade SL, Einsle O. Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium. Proceedings of the National Academy of Sciences of the United States of America. 109: 18395-400. PMID 23090993 DOI: 10.1073/Pnas.1210793109  0.722
2012 Lü W, Du J, Schwarzer NJ, Gerbig-Smentek E, Einsle O, Andrade SL. The formate channel FocA exports the products of mixed-acid fermentation. Proceedings of the National Academy of Sciences of the United States of America. 109: 13254-9. PMID 22847446 DOI: 10.1073/Pnas.1204201109  0.717
2012 Du J, Dong H, Zhou HX. Size matters in activation/inhibition of ligand-gated ion channels. Trends in Pharmacological Sciences. 33: 482-93. PMID 22789930 DOI: 10.1016/J.Tips.2012.06.005  0.372
2012 Lü W, Schwarzer N, Du J, Gerbig-Smentek E, Andrade SLA, Einsle O. Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium. Proc Natl Acad Sci U S A.  0.455
2011 Du J, Say RF, Lü W, Fuchs G, Einsle O. Active-site remodelling in the bifunctional fructose-1,6-bisphosphate aldolase/phosphatase Nature. 478: 534-537. PMID 21983965 DOI: 10.1038/Nature10458  0.591
2011 Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O. pH-dependent gating in a FocA formate channel. Science (New York, N.Y.). 332: 352-4. PMID 21493860 DOI: 10.1126/Science.1199098  0.666
2011 Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SLA, Einsle O. Mechanism of gating in the formate channel FocA from Salmonella typhimurium Science.  0.457
2010 Lü W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O. Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila. Journal of Molecular Biology. 396: 321-31. PMID 19941871 DOI: 10.1016/J.Jmb.2009.11.044  0.611
2008 Du J, Ding M, Sours-Brothers S, Graham S, Ma R. Mediation of angiotensin II-induced Ca2+ signaling by polycystin 2 in glomerular mesangial cells. American Journal of Physiology. Renal Physiology. 294: F909-18. PMID 18256307 DOI: 10.1152/ajprenal.00606.2007  0.32
2008 Zhang Y, Du J, Zhang Y, Sun HL, Pan ZW, Lu YJ, Li BX, Yang BF. [Effects of matrine, oxymatrine and resveratrol on HERG channel expression]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 42: 139-44. PMID 17518040  0.37
2007 Du J, Sours-Brothers S, Coleman R, Ding M, Graham S, Kong DH, Ma R. Canonical transient receptor potential 1 channel is involved in contractile function of glomerular mesangial cells. Journal of the American Society of Nephrology : Jasn. 18: 1437-45. PMID 17389736 DOI: 10.1681/ASN.2006091067  0.366
2006 Ma R, Du J, Sours S, Ding M. Store-operated Ca2+ channel in renal microcirculation and glomeruli. Experimental Biology and Medicine (Maywood, N.J.). 231: 145-53. PMID 16446490 DOI: 10.1177/153537020623100204  0.31
2006 Sours S, Du J, Chu S, Ding M, Zhou XJ, Ma R. Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells American Journal of Physiology - Renal Physiology. 290: F1507-F1515. PMID 16418302 DOI: 10.1152/ajprenal.00268.2005  0.406
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