| Year |
Citation |
Score |
| 2024 |
Raniga K, Nasir A, Vo NTN, Vaidyanathan R, Dickerson S, Hilcove S, Mosqueira D, Mirams GR, Clements P, Hicks R, Pointon A, Stebbeds W, Francis J, Denning C. Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. PMID 38366587 DOI: 10.1016/j.stem.2024.01.007 |
0.331 |
|
| 2024 |
Johnson BB, Cosson MV, Tsansizi LI, Holmes TL, Gilmore T, Hampton K, Song OR, Vo NTN, Nasir A, Chabronova A, Denning C, Peffers MJ, Merry CLR, Whitelock J, Troeberg L, et al. Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes. Cell Reports. 43: 113668. PMID 38198277 DOI: 10.1016/j.celrep.2023.113668 |
0.325 |
|
| 2023 |
Cumberland MJ, Euchner J, Azad AJ, T N Vo N, Kirchhof P, Holmes AP, Denning C, Gehmlich K. Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model. F1000research. 12: 1224. PMID 38298530 DOI: 10.12688/f1000research.139482.1 |
0.381 |
|
| 2023 |
Li N, Edel M, Liu K, Denning C, Betts J, Neely OC, Li D, Paterson DJ. Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220173. PMID 37122212 DOI: 10.1098/rstb.2022.0173 |
0.42 |
|
| 2022 |
Raniga K, Vo NTN, Denning C. Differentiation and Characterization of Human Pluripotent Stem Cell-Derived Cardiac Endothelial Cells for In Vitro Applications. Methods in Molecular Biology (Clifton, N.J.). 2441: 339-348. PMID 35099750 DOI: 10.1007/978-1-0716-2059-5_27 |
0.385 |
|
| 2021 |
James V, Nizamudeen ZA, Lea D, Dottorini T, Holmes TL, Johnson BB, Arkill KP, Denning C, Smith JGW. Transcriptomic analysis of cardiomyocyte extracellular vesicles in hypertrophic cardiomyopathy reveals differential snoRNA cargo. Stem Cells and Development. PMID 34806414 DOI: 10.1089/scd.2021.0202 |
0.335 |
|
| 2021 |
Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, ... ... Denning C, et al. Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes. Stem Cell Reports. PMID 34019816 DOI: 10.1016/j.stemcr.2021.04.018 |
0.455 |
|
| 2021 |
Goulding J, Kondrashov A, Mistry SJ, Melarangi T, Vo NTN, Hoang DM, White CW, Denning C, Briddon SJ, Hill SJ. The use of fluorescence correlation spectroscopy to monitor cell surface β2-adrenoceptors at low expression levels in human embryonic stem cell-derived cardiomyocytes and fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21398. PMID 33710675 DOI: 10.1096/fj.202002268R |
0.439 |
|
| 2021 |
Nasir A, Thorpe J, Burroughs L, Meurs J, Pijuan‐Galito S, Irvine DJ, Alexander MR, Denning C. Biomaterials Discovery: Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion (Adv. Healthcare Mater. 6/2021) Advanced Healthcare Materials. 10: 2170019. DOI: 10.1002/ADHM.202170019 |
0.431 |
|
| 2020 |
Nasir A, Thorpe J, Burroughs L, Meurs J, Pijuan-Galito S, Irvine DJ, Alexander MR, Denning C. Discovery of a Novel Polymer for Xeno-Free, Long-Term Culture of Human Pluripotent Stem Cell Expansion. Advanced Healthcare Materials. e2001448. PMID 33369242 DOI: 10.1002/adhm.202001448 |
0.357 |
|
| 2020 |
Mannhardt I, Saleem U, Mosqueira D, Loos MF, Ulmer BM, Lemoine MD, Larsson C, Améen C, de Korte T, Vlaming MLH, Harris K, Clements P, Denning C, Hansen A, Eschenhagen T. Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format. Stem Cell Reports. 15: 983-998. PMID 33053362 DOI: 10.1016/j.stemcr.2020.09.002 |
0.329 |
|
| 2020 |
Bodbin SE, Denning C, Mosqueira D. Transfection of hPSC-Cardiomyocytes Using Viafect™ Transfection Reagent. Methods and Protocols. 3. PMID 32784848 DOI: 10.3390/mps3030057 |
0.355 |
|
| 2020 |
Kargaran PK, Evans JM, Bodbin SE, Smith JGW, Nelson TJ, Denning C, Mosqueira D. Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy. Journal of Clinical Medicine. 9. PMID 32718021 DOI: 10.3390/Jcm9082349 |
0.333 |
|
| 2020 |
Bhagwan JR, Mosqueira D, Chairez-Cantu K, Mannhardt I, Bodbin SE, Bakar M, Smith JGW, Denning C. Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics. Journal of Molecular and Cellular Cardiology. PMID 32531470 DOI: 10.1016/J.Yjmcc.2020.06.003 |
0.345 |
|
| 2020 |
Saleem U, van Meer BJ, Katili PA, Yusof NANM, Mannhardt I, Garcia AK, Tertoolen L, de Korte T, Vlaming MLH, McGlynn K, Nebel J, Bahinski A, Harris K, Rossman E, Xu X, ... ... Denning C, et al. Blinded, multi-centre evaluation of drug-induced changes in contractility using human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32421822 DOI: 10.1093/Toxsci/Kfaa058 |
0.435 |
|
| 2019 |
Bhagwan JR, Collins E, Mosqueira D, Bakar M, Johnson BB, Thompson A, Smith JGW, Denning C. Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the locus as not an entirely safe harbour. F1000research. 8: 1911. PMID 32789000 DOI: 10.12688/F1000Research.19894.1 |
0.431 |
|
| 2019 |
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, et al. N-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature Genetics. PMID 31844323 DOI: 10.1038/S41588-019-0549-X |
0.63 |
|
| 2019 |
van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL. Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes. Nature Communications. 10: 4325. PMID 31541103 DOI: 10.1038/S41467-019-12354-8 |
0.349 |
|
| 2019 |
de Korte T, Katili PA, Mohd Yusof NAN, van Meer BJ, Saleem U, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C. Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive? Annual Review of Pharmacology and Toxicology. PMID 31506008 DOI: 10.1146/Annurev-Pharmtox-010919-023309 |
0.438 |
|
| 2019 |
Alvarez-Paino M, Amer MH, Nasir A, Cuzzucoli Crucitti V, Thorpe J, Burroughs L, Needham D, Denning C, Alexander MR, Alexander C, Rose FRAJ. Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function. Acs Applied Materials & Interfaces. PMID 31502820 DOI: 10.1021/Acsami.9B04769 |
0.456 |
|
| 2019 |
Mosqueira D, Smith JGW, Bhagwan JR, Denning C. Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention. Trends in Molecular Medicine. PMID 31324451 DOI: 10.1016/J.Molmed.2019.06.005 |
0.407 |
|
| 2019 |
Howe CL, Webb KF, Abayzeed SA, Anderson DJ, Denning C, Russell NA. Surface plasmon resonance imaging of excitable cells. Journal of Physics D: Applied Physics. 52: 104001. PMID 30867618 DOI: 10.1088/1361-6463/Aaf849 |
0.311 |
|
| 2019 |
Diksin M, Rowlinson J, Kondrashov A, Denning C, Hughes J, Constantin-Teodosiu T, Cui W, Scurr D, Ahmad O, Gell C, Onion D, Croxall N, Smith S, Rahman R. TMOD-11. CHARACTERISATION OF THE POST-SURGICAL INVASIVE TUMOUR NICHE USING ASTROCYTE-GLIOBLASTOMA ORGANOIDS AND DECELLULARISED HUMAN BRAIN Neuro-Oncology. 21: vi264-vi265. DOI: 10.1093/Neuonc/Noz175.1110 |
0.441 |
|
| 2019 |
Diksin M, Rowlinson J, Kondrashov A, Denning C, Hughes J, Constantin-Teodo T, Cui W, Gell C, Onion D, Croxall N, Smith S, Rahman R. Characterisation of the invasive tumour niche using astrocyte-glioblastoma organoids and decellularised human brain Neuro-Oncology. 21: iv7-iv7. DOI: 10.1093/Neuonc/Noz167.028 |
0.444 |
|
| 2018 |
Smith JGW, Owen T, Bhagwan JR, Mosqueira D, Scott E, Mannhardt I, Patel A, Barriales-Villa R, Monserrat L, Hansen A, Eschenhagen T, Harding SE, Marston S, Denning C. Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits. Stem Cell Reports. PMID 30392975 DOI: 10.1016/J.Stemcr.2018.10.006 |
0.41 |
|
| 2018 |
Harrison R, Lugo Leija HA, Strohbuecker S, Crutchley J, Marsh S, Denning C, El Haj A, Sottile V. Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing. Stem Cell Research & Therapy. 9: 248. PMID 30257709 DOI: 10.1186/S13287-018-0968-0 |
0.427 |
|
| 2018 |
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, ... ... Denning C, et al. CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. European Heart Journal. PMID 29741611 DOI: 10.1093/Eurheartj/Ehy249 |
0.516 |
|
| 2018 |
Kondrashov A, Duc Hoang M, Smith J, Bhagwan J, Duncan G, Mosqueira D, Munoz M, Vo NTN, Denning C. Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells. Stem Cells and Development. PMID 29402189 DOI: 10.1089/Scd.2017.0268 |
0.472 |
|
| 2017 |
Sala L, van Meer BJ, Tertoolen LT, Bakkers J, Bellin M, Davis RP, Denning CN, Dieben MA, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman E, Jongbloed MR, Kamel SM, et al. MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo. Circulation Research. PMID 29282212 DOI: 10.1161/Circresaha.117.312067 |
0.397 |
|
| 2017 |
Duncan G, Firth K, George V, Hoang MD, Staniforth A, Smith G, Denning C. Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytes. Stem Cells and Development. PMID 28992755 DOI: 10.1089/Scd.2017.0172 |
0.433 |
|
| 2017 |
Lewis LC, Lo PC, Foster JM, Dai N, Corrêa IR, Durczak PM, Duncan G, Ramsawhook A, Aithal GP, Denning C, Hannan NR, Ruzov A. Dynamics of 5-carboxylcytosine during hepatic differentiation: potential general role for active demethylation by DNA repair in lineage specification. Epigenetics. 0. PMID 28267381 DOI: 10.1080/15592294.2017.1292189 |
0.463 |
|
| 2017 |
Harris K, Rossman E, Xu X, Clements P, Mannhardt I, Hansen A, Saleem U, Eschenhagen T, Hortigon M, Rodriguez VZ, Smith G, van Meer B, Tertoolen L, Mummery C, Ribeiro M, ... ... Denning C, et al. InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility Journal of Pharmacological and Toxicological Methods. 88: 238. DOI: 10.1016/J.Vascn.2017.09.228 |
0.514 |
|
| 2016 |
van Meer BJ, de Vries H, Firth KSA, van Weerd J, Tertoolen LGJ, Karperien HBJ, Jonkheijm P, Denning C, IJzerman AP, Mummery CL. Small molecule absorption by PDMS in the context of drug response bioassays. Biochemical and Biophysical Research Communications. 482: 323-328. PMID 27856254 DOI: 10.1016/J.Bbrc.2016.11.062 |
0.307 |
|
| 2016 |
Kalra S, Montanaro F, Denning C. Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies? Journal of Neuromuscular Diseases. 3: 309-332. PMID 27854224 DOI: 10.3233/Jnd-150133 |
0.399 |
|
| 2016 |
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, et al. Stem cell-derived models to improve mechanistic understanding and prediction of human drug induced liver injury. Hepatology (Baltimore, Md.). PMID 27775817 DOI: 10.1002/Hep.28886 |
0.529 |
|
| 2016 |
Hammad M, Rao W, Smith JG, Anderson DG, Langer R, Young LE, Barrett DA, Davies MC, Denning C, Alexander MR. Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion. Biomaterials Science. PMID 27466628 DOI: 10.1039/C6Bm00214E |
0.704 |
|
| 2016 |
Rajamohan D, Kalra S, Hoang MD, George V, Staniforth A, Russell H, Yang X, Denning C. Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells and Development. PMID 26906236 DOI: 10.1089/Scd.2015.0253 |
0.518 |
|
| 2016 |
Dixon JE, Osman G, Morris GE, Markides H, Rotherham M, Bayoussef Z, El Haj AJ, Denning C, Shakesheff KM. Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. Proceedings of the National Academy of Sciences of the United States of America. 113: E291-9. PMID 26733682 DOI: 10.1073/Pnas.1518634113 |
0.456 |
|
| 2015 |
Smith JG, Celiz AD, Patel AK, Short RD, Alexander MR, Denning C. Scaling human pluripotent stem cell expansion and differentiation: are cell factories becoming a reality? Regenerative Medicine. PMID 26542310 DOI: 10.2217/Rme.15.65 |
0.553 |
|
| 2015 |
Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE. Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochimica Et Biophysica Acta. PMID 26524115 DOI: 10.1016/J.Bbamcr.2015.10.014 |
0.687 |
|
| 2015 |
Ghita A, Pascut FC, Sottile V, Denning C, Notingher I. Applications of Raman micro-spectroscopy to stem cell technology: label-free molecular discrimination and monitoring cell differentiation. Epj Techniques and Instrumentation. 2: 6. PMID 26161299 DOI: 10.1140/Epjti/S40485-015-0016-8 |
0.51 |
|
| 2015 |
Celiz AD, Smith JG, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, ... ... Denning C, et al. Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials (Deerfield Beach, Fla.). 27: 4006-12. PMID 26033422 DOI: 10.1002/Adma.201501351 |
0.717 |
|
| 2015 |
Patel AK, Celiz AD, Rajamohan D, Anderson DG, Langer R, Davies MC, Alexander MR, Denning C. A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays. Biomaterials. 61: 257-65. PMID 26005764 DOI: 10.1016/J.Biomaterials.2015.05.019 |
0.5 |
|
| 2015 |
Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Disease Models & Mechanisms. 8: 457-66. PMID 25791035 DOI: 10.1242/Dev.125161 |
0.455 |
|
| 2015 |
Patel AK, Tibbitt MW, Celiz AD, Davies MC, Langer R, Denning C, Alexander MR, Anderson DG. High throughput screening for discovery of materials that control stem cell fate Current Opinion in Solid State and Materials Science. DOI: 10.1016/J.Cossms.2016.02.002 |
0.452 |
|
| 2014 |
Földes G, Matsa E, Kriston-Vizi J, Leja T, Amisten S, Kolker L, Kodagoda T, Dolatshad NF, Mioulane M, Vauchez K, Arányi T, Ketteler R, Schneider MD, Denning C, Harding SE. Aberrant α-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells. Stem Cell Reports. 3: 905-14. PMID 25418732 DOI: 10.1016/J.Stemcr.2014.09.002 |
0.474 |
|
| 2014 |
Celiz AD, Smith JG, Patel AK, Langer R, Anderson DG, Barrett DA, Young LE, Davies MC, Denning C, Alexander MR. Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4bm00054dClick here for additional data file. Biomaterials Science. 2: 1604-1611. PMID 25328672 DOI: 10.1039/C4Bm00054D |
0.659 |
|
| 2014 |
Celiz AD, Smith JG, Langer R, Anderson DG, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR. Materials for stem cell factories of the future. Nature Materials. 13: 570-9. PMID 24845996 DOI: 10.1038/Nmat3972 |
0.68 |
|
| 2014 |
Dixon JE, Shah DA, Rogers C, Hall S, Weston N, Parmenter CD, McNally D, Denning C, Shakesheff KM. Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 5580-5. PMID 24706900 DOI: 10.1073/Pnas.1319685111 |
0.509 |
|
| 2014 |
Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C. Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. European Heart Journal. 35: 1078-87. PMID 23470493 DOI: 10.1093/Eurheartj/Eht067 |
0.5 |
|
| 2013 |
Dick E, Kalra S, Anderson D, George V, Ritso M, Laval SH, Barresi R, Aartsma-Rus A, Lochmüller H, Denning C. Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells-cardiomyocytes harboring DMD mutations. Stem Cells and Development. 22: 2714-24. PMID 23829870 DOI: 10.1089/Scd.2013.0135 |
0.452 |
|
| 2013 |
Dick E, Kalra S, Anderson D, George V, Ritson M, Laval S, Barresi R, Aartsma-Rus A, Lochmuller H, Denning C. Exon skipping and gene transfer restore dystrophin expression in hiPSC-cardiomyocytes harbouring DMD mutations. Stem Cells and Development. PMID 23786351 DOI: 10.1089/2013.0135 |
0.409 |
|
| 2013 |
Pascut FC, Kalra S, George V, Welch N, Denning C, Notingher I. Non-invasive label-free monitoring the cardiac differentiation of human embryonic stem cells in-vitro by Raman spectroscopy. Biochimica Et Biophysica Acta. 1830: 3517-24. PMID 23403134 DOI: 10.1016/J.Bbagen.2013.01.030 |
0.532 |
|
| 2013 |
Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Research. 10: 48-56. PMID 23089628 DOI: 10.1016/J.Scr.2012.08.007 |
0.418 |
|
| 2013 |
Rajamohan D, Matsa E, Kalra S, Crutchley J, Patel A, George V, Denning C. Current status of drug screening and disease modelling in human pluripotent stem cells. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 281-98. PMID 22886688 DOI: 10.1002/Bies.201200053 |
0.526 |
|
| 2013 |
Foldes G, Matsa E, Kriston-Vizi J, Leja T, Mioulane M, Vauchez K, Ketteler R, Schneider MD, Denning C, Harding SE. Key differences in hypertrophic signalling between hESC- and hIPSC-derived cardiomyocytes European Heart Journal. 34: P1458-P1458. DOI: 10.1093/Eurheartj/Eht308.P1458 |
0.49 |
|
| 2012 |
Matsa E, Denning C. In vitro uses of human pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Translational Research. 5: 581-92. PMID 22639342 DOI: 10.1007/S12265-012-9376-5 |
0.558 |
|
| 2012 |
Paik I, Scurr DJ, Morris B, Hall G, Denning C, Alexander MR, Shakesheff KM, Dixon JE. Rapid micropatterning of cell lines and human pluripotent stem cells on elastomeric membranes. Biotechnology and Bioengineering. 109: 2630-41. PMID 22511037 DOI: 10.1002/Bit.24529 |
0.502 |
|
| 2012 |
Almeida RD, Loose M, Sottile V, Matsa E, Denning C, Young L, Johnson AD, Gering M, Ruzov A. 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics : Official Journal of the Dna Methylation Society. 7: 383-9. PMID 22419071 DOI: 10.4161/Epi.19375 |
0.683 |
|
| 2011 |
Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, ... ... Denning C, et al. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nature Biotechnology. 29: 1132-44. PMID 22119741 DOI: 10.1038/Nbt.2051 |
0.725 |
|
| 2011 |
Dixon JE, Dick E, Rajamohan D, Shakesheff KM, Denning C. Directed differentiation of human embryonic stem cells to interrogate the cardiac gene regulatory network. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1695-703. PMID 21694703 DOI: 10.1038/Mt.2011.125 |
0.505 |
|
| 2011 |
Dick E, Matsa E, Young LE, Darling D, Denning C. Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection. Nature Protocols. 6: 701-14. PMID 21637193 DOI: 10.1038/Nprot.2011.320 |
0.716 |
|
| 2011 |
Pascut FC, Goh HT, George V, Denning C, Notingher I. Toward label-free Raman-activated cell sorting of cardiomyocytes derived from human embryonic stem cells. Journal of Biomedical Optics. 16: 045002. PMID 21529069 DOI: 10.1117/1.3570302 |
0.518 |
|
| 2011 |
Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A, Denning C. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. European Heart Journal. 32: 952-62. PMID 21367833 DOI: 10.1093/Eurheartj/Ehr073 |
0.666 |
|
| 2011 |
Pascut FC, Goh HT, Welch N, Buttery LD, Denning C, Notingher I. Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells. Biophysical Journal. 100: 251-9. PMID 21190678 DOI: 10.1016/J.Bpj.2010.11.043 |
0.469 |
|
| 2011 |
Dick E, Matsa E, Bispham J, Reza M, Guglieri M, Staniforth A, Watson S, Kumari R, Lochmüller H, Young L, Darling D, Denning C. Two new protocols to enhance the production and isolation of human induced pluripotent stem cell lines. Stem Cell Research. 6: 158-67. PMID 21095172 DOI: 10.1016/J.Scr.2010.10.002 |
0.732 |
|
| 2011 |
Ritso M, Dick E, Reza M, Laval S, Bushby K, Straub V, Denning C, Lochmuller H. P4.36 Develoment of pluripotent stem celss as vectors for viral gene therapy Neuromuscular Disorders. 21: 715. DOI: 10.1016/J.Nmd.2011.06.1001 |
0.378 |
|
| 2011 |
Kane NM, Denning C, Baker AH. Genetic modification of human embryonic and induced pluripotent stem cells: Viral and non-viral approaches Stem Cell Engineering: Principles and Applications. 159-179. DOI: 10.1007/978-3-642-11865-4_7 |
0.408 |
|
| 2010 |
Dick E, Rajamohan D, Ronksley J, Denning C. Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening. Biochemical Society Transactions. 38: 1037-45. PMID 20659000 DOI: 10.1042/Bst0381037 |
0.557 |
|
| 2010 |
Priddle H, Allegrucci C, Burridge P, Munoz M, Smith NM, Devlin L, Sjoblom C, Chamberlain S, Watson S, Young LE, Denning C. Derivation and characterisation of the human embryonic stem cell lines, NOTT1 and NOTT2. In Vitro Cellular & Developmental Biology. Animal. 46: 367-75. PMID 20177995 DOI: 10.1007/S11626-010-9290-6 |
0.806 |
|
| 2010 |
Braam SR, Denning C, Mummery CL. Genetic manipulation of human embryonic stem cells in serum and feeder-free media. Methods in Molecular Biology (Clifton, N.J.). 584: 413-23. PMID 19907990 DOI: 10.1007/978-1-60761-369-5_22 |
0.539 |
|
| 2010 |
Mahlstedt MM, Anderson D, Sharp JS, McGilvray R, Muñoz MD, Buttery LD, Alexander MR, Rose FR, Denning C. Maintenance of pluripotency in human embryonic stem cells cultured on a synthetic substrate in conditioned medium. Biotechnology and Bioengineering. 105: 130-40. PMID 19718698 DOI: 10.1002/Bit.22520 |
0.53 |
|
| 2009 |
Priddle H, Grabowska A, Morris T, Clarke PA, McKenzie AJ, Sottile V, Denning C, Young L, Watson S. Bioluminescence imaging of human embryonic stem cells transplanted in vivo in murine and chick models. Cloning and Stem Cells. 11: 259-67. PMID 19522673 DOI: 10.1089/Clo.2008.0056 |
0.681 |
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| 2009 |
Thomas RJ, Anderson D, Chandra A, Smith NM, Young LE, Williams D, Denning C. Automated, scalable culture of human embryonic stem cells in feeder-free conditions. Biotechnology and Bioengineering. 102: 1636-44. PMID 19062183 DOI: 10.1002/Bit.22187 |
0.745 |
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| 2008 |
Braam SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL. Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Nature Protocols. 3: 1435-43. PMID 18772870 DOI: 10.1038/Nprot.2008.140 |
0.719 |
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| 2008 |
Braam SR, Denning C, van den Brink S, Kats P, Hochstenbach R, Passier R, Mummery CL. Improved genetic manipulation of human embryonic stem cells. Nature Methods. 5: 389-92. PMID 18391958 DOI: 10.1038/Nmeth.1200 |
0.554 |
|
| 2008 |
Kane NM, McRae S, Denning C, Baker AH. Viral and non-viral gene delivery and its role in pluripotent stem cell engineering Drug Discovery Today: Technologies. 5: e107-e115. DOI: 10.1016/J.Ddtec.2008.10.002 |
0.554 |
|
| 2008 |
Denning C, Anderson D. Cardiomyocytes from human embryonic stem cells as predictors of cardiotoxicity Drug Discovery Today: Therapeutic Strategies. 5: 223-232. DOI: 10.1016/J.Ddstr.2008.08.002 |
0.539 |
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| 2007 |
Kim KP, Thurston A, Mummery C, Ward-van Oostwaard D, Priddle H, Allegrucci C, Denning C, Young L. Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines. Genome Research. 17: 1731-42. PMID 17989250 DOI: 10.1101/Gr.6609207 |
0.734 |
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| 2007 |
Anderson D, Self T, Mellor IR, Goh G, Hill SJ, Denning C. Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 2027-36. PMID 17895862 DOI: 10.1038/Sj.Mt.6300303 |
0.56 |
|
| 2007 |
Allegrucci C, Wu YZ, Thurston A, Denning CN, Priddle H, Mummery CL, Ward-van Oostwaard D, Andrews PW, Stojkovic M, Smith N, Parkin T, Jones ME, Warren G, Yu L, Brena RM, et al. Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Human Molecular Genetics. 16: 1253-68. PMID 17409196 DOI: 10.1093/Hmg/Ddm074 |
0.694 |
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| 2007 |
Burridge PW, Anderson D, Priddle H, Barbadillo Muñoz MD, Chamberlain S, Allegrucci C, Young LE, Denning C. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells (Dayton, Ohio). 25: 929-38. PMID 17185609 DOI: 10.1634/Stemcells.2006-0598 |
0.761 |
|
| 2007 |
Young LE, Denning C. Oct4 during the pluripotency differentiation transition: Who is regulating the regulator? Regenerative Medicine. 2: 211-215. DOI: 10.2217/17460751.2.2.211 |
0.706 |
|
| 2007 |
Mummery C, Passier R, Denning C. Part A: Directed Differentiation of Human Embryonic Stem Cells into Cardiomyocytes Human Embryonic Stem Cells: the Practical Handbook. 213-228. DOI: 10.1002/9780470511619.ch13a |
0.487 |
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| 2006 |
Clark AJ, Burl S, Denning C. Genetic modification of sheep by nuclear transfer with gene-targeted somatic cells. Methods in Molecular Biology (Clifton, N.J.). 348: 199-212. PMID 16988381 DOI: 10.1007/978-1-59745-154-3_13 |
0.436 |
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| 2006 |
Porter G, Denning C, Plomer A, Sinden J, Torremans P. The patentability of human embryonic stem cells in Europe. Nature Biotechnology. 24: 653-5. PMID 16763591 DOI: 10.1038/Nbt0606-653 |
0.508 |
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| 2006 |
Denning C, Allegrucci C, Priddle H, Barbadillo-Muñoz MD, Anderson D, Self T, Smith NM, Parkin CT, Young LE. Common culture conditions for maintenance and cardiomyocyte differentiation of the human embryonic stem cell lines, BG01 and HUES-7. The International Journal of Developmental Biology. 50: 27-37. PMID 16323075 DOI: 10.1387/Ijdb.052107Cd |
0.726 |
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| 2006 |
Denning C. Gene Targeting and Embryonic Stem Cells. Advanced Methods. Edited by Alison Thomson and , Jim McWhir. London and New York: BIOS Scientific Publishers. $59.95 (paper). ix + 205 p; ill.; index. ISBN: 1–85996– 360–9. 2004. The Quarterly Review of Biology. 81: 61-61. DOI: 10.1086/503949 |
0.316 |
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| 2006 |
Passier R, Denning C, Mummery C. Cardiomyocytes from human embryonic stem cells. Handbook of Experimental Pharmacology. 174: 101-122. DOI: 10.1007/3-540-31265-X_5 |
0.568 |
|
| 2005 |
van de Stolpe A, van den Brink S, van Rooijen M, Ward-van Oostwaard D, van Inzen W, Slaper-Cortenbach I, Fauser B, van den Hout N, Weima S, Passier R, Smith N, Denning C, Mummery C. Human embryonic stem cells: towards therapies for cardiac disease. Derivation of a Dutch human embryonic stem cell line. Reproductive Biomedicine Online. 11: 476-85. PMID 16274613 DOI: 10.1016/S1472-6483(10)61144-3 |
0.574 |
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| 2005 |
Goh G, Self T, Barbadillo Muñoz MD, Hall IP, Young L, Denning C. Molecular and phenotypic analyses of human embryonic stem cell-derived cardiomyocytes: opportunities and challenges for clinical translation. Thrombosis and Haemostasis. 94: 728-37. PMID 16270624 DOI: 10.1160/Th05-04-0268 |
0.744 |
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| 2005 |
Allegrucci C, Denning CN, Burridge P, Steele W, Sinclair KD, Young LE. Human embryonic stem cells as a model for nutritional programming: an evaluation. Reproductive Toxicology (Elmsford, N.Y.). 20: 353-67. PMID 15975761 DOI: 10.1016/J.Reprotox.2005.04.010 |
0.771 |
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| 2005 |
Steele W, Allegrucci C, Singh R, Lucas E, Priddle H, Denning C, Sinclair K, Young L. Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction? Reproductive Biomedicine Online. 10: 755-66. PMID 15970006 DOI: 10.1016/S1472-6483(10)61120-0 |
0.671 |
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| 2005 |
Smith N, Denning C, Priddle H, Allegrucci C, Ward-van OD, Mummery C, Parkin C, Young L. P▪36 Cytogenetic abnormalities in human embryonic stem cell lines Reproductive Biomedicine Online. 10: 42-43. DOI: 10.1016/S1472-6483(11)60358-1 |
0.56 |
|
| 2004 |
Allegrucci C, Denning C, Priddle H, Young L. Stem-cell consequences of embryo epigenetic defects. Lancet. 364: 206-8. PMID 15246736 DOI: 10.1016/S0140-6736(04)16636-1 |
0.647 |
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| 2003 |
Denning C, Priddle H. New frontiers in gene targeting and cloning: success, application and challenges in domestic animals and human embryonic stem cells. Reproduction (Cambridge, England). 126: 1-11. PMID 12814342 DOI: 10.1530/Rep.0.1260001 |
0.552 |
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| 2003 |
Clark AJ, Ferrier P, Aslam S, Burl S, Denning C, Wylie D, Ross A, de Sousa P, Wilmut I, Cui W. Proliferative lifespan is conserved after nuclear transfer. Nature Cell Biology. 5: 535-8. PMID 12738962 DOI: 10.1038/Ncb992 |
0.405 |
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| 2001 |
Denning C, Dickinson P, Burl S, Wylie D, Fletcher J, Clark AJ. Gene targeting in primary fetal fibroblasts from sheep and pig. Cloning and Stem Cells. 3: 221-31. PMID 11945232 DOI: 10.1089/15362300152725945 |
0.366 |
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| 2001 |
Denning C, Burl S, Ainslie A, Bracken J, Dinnyes A, Fletcher J, King T, Ritchie M, Ritchie WA, Rollo M, de Sousa P, Travers A, Wilmut I, Clark AJ. Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep. Nature Biotechnology. 19: 559-62. PMID 11385461 DOI: 10.1038/89313 |
0.333 |
|
| 2000 |
Clark AJ, Burl S, Denning C, Dickinson P. Gene targeting in livestock: a preview. Transgenic Research. 9: 263-75. PMID 11131006 DOI: 10.1023/A:1008974616402 |
0.333 |
|
| 1997 |
Denning C, Pitts JD. Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes. Human Gene Therapy. 8: 1825-35. PMID 9358032 DOI: 10.1089/Hum.1997.8.15-1825 |
0.363 |
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