| Year |
Citation |
Score |
| 2024 |
Alzain AA, Elbadwi FA, Shoaib TH, Sherif AE, Osman W, Ashour A, Mohamed GA, Ibrahim SRM, Roh EJ, Hassan AHE. Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies. Frontiers in Chemistry. 12: 1339891. PMID 38318109 DOI: 10.3389/fchem.2024.1339891 |
0.365 |
|
| 2023 |
Zaki WA, El-Sayed SM, Alswah M, El-Morsy A, Bayoumi AH, Mayhoub AS, Moustafa WH, Awaji AA, Roh EJ, Hassan AHE, Mahmoud K. Design, Synthesis, In Vitro, and In Silico Studies of New -Substituted-pyrazolo[3,4-]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors. Pharmaceuticals (Basel, Switzerland). 16. PMID 38004458 DOI: 10.3390/ph16111593 |
0.333 |
|
| 2023 |
Lee EH, Park JE, Gotina L, Han YE, Viswanath ANI, Yoo S, Moon B, Hwang JY, Park WK, Cho Y, Song C, Min SJ, Hwang EM, Lee H, Pae AN, ... Roh EJ, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 165: 115139. PMID 37454597 DOI: 10.1016/j.biopha.2023.115139 |
0.319 |
|
| 2022 |
Elkamhawy A, Paik S, Ali EMH, Hassan AHE, Kang SJ, Lee K, Roh EJ. Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies. Pharmaceuticals (Basel, Switzerland). 15. PMID 36145271 DOI: 10.3390/ph15091050 |
0.486 |
|
| 2022 |
Park S, Ahn Y, Kim Y, Roh EJ, Lee Y, Han C, Yoo HM, Yu J. Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA and hA Adenosine Receptor. Molecules (Basel, Switzerland). 27. PMID 35807265 DOI: 10.3390/molecules27134016 |
0.591 |
|
| 2022 |
Elsherbeny MH, Ammar UM, Abdellattif MH, Abourehab MAS, Abdeen A, Ibrahim SF, Abdelrahaman D, Mady W, Roh EJ, Elkamhawy A. 2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation. Life (Basel, Switzerland). 12. PMID 35743907 DOI: 10.3390/life12060876 |
0.366 |
|
| 2022 |
Farag AK, Ahn BS, Yoo JS, Karam R, Roh EJ. Design, synthesis, and biological evaluation of pseudo-bicyclic pyrimidine-based compounds as potential EGFR inhibitors. Bioorganic Chemistry. 126: 105918. PMID 35696765 DOI: 10.1016/j.bioorg.2022.105918 |
0.324 |
|
| 2021 |
Elsherbeny MH, Kim J, Gouda NA, Gotina L, Cho J, Pae AN, Lee K, Park KD, Elkamhawy A, Roh EJ. Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress. Antioxidants (Basel, Switzerland). 10. PMID 34679775 DOI: 10.3390/antiox10101641 |
0.522 |
|
| 2021 |
Elkamhawy A, Woo J, Gouda NA, Kim J, Nada H, Roh EJ, Park KD, Cho J, Lee K. Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress. Antioxidants (Basel, Switzerland). 10. PMID 34679739 DOI: 10.3390/antiox10101604 |
0.492 |
|
| 2021 |
Elsherbeny MH, Elkamhawy A, Nada H, Abdellattif MH, Lee K, Roh EJ. Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity. Biomedicines. 9. PMID 34572319 DOI: 10.3390/biomedicines9091131 |
0.488 |
|
| 2021 |
Elkamhawy A, Kim HJ, Elsherbeny MH, Paik S, Park JH, Gotina L, Abdellattif MH, Gouda NA, Cho J, Lee K, Nim Pae A, Park KD, Roh EJ. Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action. Bioorganic Chemistry. 116: 105352. PMID 34562673 DOI: 10.1016/j.bioorg.2021.105352 |
0.525 |
|
| 2021 |
Elkamhawy A, Ammar UM, Paik S, Abdellattif MH, Elsherbeny MH, Lee K, Roh EJ. Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening. Molecules (Basel, Switzerland). 26. PMID 34500757 DOI: 10.3390/molecules26175324 |
0.536 |
|
| 2021 |
Elkamhawy A, Paik S, Park JH, Kim HJ, Hassan AHE, Lee K, Park KD, Roh EJ. Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies. Bioorganic Chemistry. 115: 105233. PMID 34390968 DOI: 10.1016/j.bioorg.2021.105233 |
0.532 |
|
| 2020 |
Elkamhawy A, Paik S, Kim HJ, Park JH, Londhe AM, Lee K, Pae AN, Park KD, Roh EJ. Discovery of -(1-(3-fluorobenzoyl)-1-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1568-1580. PMID 32752896 DOI: 10.1080/14756366.2020.1800666 |
0.526 |
|
| 2020 |
Farag AK, Hassan AHE, Chung KS, Lee JH, Gil HS, Lee KT, Roh EJ. Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches. Bioorganic Chemistry. 103: 104121. PMID 32745753 DOI: 10.1016/j.bioorg.2020.104121 |
0.36 |
|
| 2020 |
Farag AK, Hassan AHE, Ahn BS, Park KD, Roh EJ. Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 311-324. PMID 31809612 DOI: 10.1080/14756366.2019.1699554 |
0.349 |
|
| 2019 |
Elkamhawy A, Kim NY, Hassan AHE, Park JE, Paik S, Yang JE, Oh KS, Lee BH, Lee MY, Shin KJ, Pae AN, Lee KT, Roh EJ. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. European Journal of Medicinal Chemistry. 188: 111955. PMID 31893550 DOI: 10.1016/j.ejmech.2019.111955 |
0.322 |
|
| 2018 |
Farag AK, Hassan AHE, Jeong H, Kwon Y, Choi JG, Oh MS, Park KD, Kim YK, Roh EJ. First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl)amino)pyrimidin-5-yl)benzamide as a potential anti-tauopathies agent. European Journal of Medicinal Chemistry. 162: 161-175. PMID 30445265 DOI: 10.1016/j.ejmech.2018.10.057 |
0.335 |
|
| 2018 |
Choi MJ, Roh EJ, Hur W, Lee SH, Sim T, Oh CH, Lee SH, Kim JS, Yoo KH. Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30340900 DOI: 10.1016/j.bmcl.2018.10.013 |
0.347 |
|
| 2017 |
Farag AK, Elkamhawy A, Londhe AM, Lee KT, Pae AN, Roh EJ. Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders. European Journal of Medicinal Chemistry. PMID 29107425 DOI: 10.1016/j.ejmech.2017.10.003 |
0.331 |
|
| 2017 |
Elkamhawy A, Paik S, Hassan AHE, Lee YS, Roh EJ. Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library. Bioorganic Chemistry. 75: 393-405. PMID 29102722 DOI: 10.1016/j.bioorg.2017.10.009 |
0.347 |
|
| 2017 |
Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Park BG, Paik S, Do J, Park JH, Park KD, Moon B, Park WK, Cho H, Jeong DY, Roh EJ. Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28435076 DOI: 10.1016/J.Ejps.2017.04.015 |
0.314 |
|
| 2015 |
Elkamhawy A, Viswanath AN, Pae AN, Kim HY, Heo JC, Park WK, Lee CO, Yang H, Kim KH, Nam DH, Seol HJ, Cho H, Roh EJ. Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). European Journal of Medicinal Chemistry. 103: 210-222. PMID 26355532 DOI: 10.1016/J.Ejmech.2015.08.001 |
0.345 |
|
| 2015 |
Elkamhawy A, Park JE, Cho NC, Sim T, Pae AN, Roh EJ. Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-9. PMID 25807298 DOI: 10.3109/14756366.2015.1004057 |
0.31 |
|
| 2014 |
Elkamhawy A, Lee J, Park BG, Park I, Pae AN, Roh EJ. Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study. European Journal of Medicinal Chemistry. 84: 466-75. PMID 25050879 DOI: 10.1016/J.Ejmech.2014.07.027 |
0.315 |
|
| 2014 |
Park BS, Al-Sanea MM, Abdelazem AZ, Park HM, Roh EJ, Park HM, Yoo KH, Sim T, Tae JS, Lee SH. Structure-based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors. Bioorganic & Medicinal Chemistry. 22: 3871-8. PMID 24997577 DOI: 10.1016/j.bmc.2014.06.020 |
0.368 |
|
| 2012 |
Song H, Lee YS, Roh EJ, Seo JH, Oh KS, Lee BH, Han H, Shin KJ. Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy. Bioorganic & Medicinal Chemistry Letters. 22: 5668-74. PMID 22858099 DOI: 10.1016/j.bmcl.2012.06.088 |
0.345 |
|
| 2011 |
Kim S, Jung JK, Lee HS, Kim Y, Kim J, Choi K, Baek DJ, Moon B, Oh KS, Lee BH, Shin KJ, Pae AN, Nam G, Roh EJ, Cho YS, et al. Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 3002-6. PMID 21489792 DOI: 10.1016/J.Bmcl.2011.03.044 |
0.317 |
|
| 2008 |
Roh EJ, Keller JM, Olah Z, Iadarola MJ, Jacobson KA. Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorganic & Medicinal Chemistry. 16: 9349-58. PMID 18809334 DOI: 10.1016/J.Bmc.2008.08.048 |
0.36 |
|
| 2007 |
Costanzi S, Tikhonova IG, Ohno M, Roh EJ, Joshi BV, Colson AO, Houston D, Maddileti S, Harden TK, Jacobson KA. P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring. Journal of Medicinal Chemistry. 50: 3229-41. PMID 17564423 DOI: 10.1021/Jm0700971 |
0.589 |
|
| 2006 |
Jacobson KA, Costanzi S, Kim SK, Roh E, Joshi BV, Tchilibon S, Duong HT, Gao ZG. Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors. Nucleosides, Nucleotides & Nucleic Acids. 25: 1425-36. PMID 17067963 DOI: 10.1080/15257770600919027 |
0.6 |
|
| 2006 |
Hechler B, Nonne C, Roh EJ, Cattaneo M, Cazenave JP, Lanza F, Jacobson KA, Gachet C. MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. The Journal of Pharmacology and Experimental Therapeutics. 316: 556-63. PMID 16236815 DOI: 10.1124/Jpet.105.094037 |
0.465 |
|
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