| Year |
Citation |
Score |
| 2022 |
Huppelschoten Y, Mukhopadhyay RVH, Buchardt J, Nielsen TE, Vertegaal ACO, Ovaa H, van der Heden van Noort G. In-plate Chemical Synthesis of Isopeptide-linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP preferences. Chembiochem : a European Journal of Chemical Biology. PMID 36377600 DOI: 10.1002/cbic.202200601 |
0.313 |
|
| 2020 |
Kooij R, Liu S, Sapmaz A, Xin BT, Janssen GMC, van Veelen PA, Ovaa H, Ten Dijke P, Geurink PP. A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. Journal of the American Chemical Society. PMID 32886496 DOI: 10.1021/Jacs.0C07726 |
0.431 |
|
| 2020 |
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, ... ... Ovaa H, et al. Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. The Embo Journal. e106275. PMID 32845033 DOI: 10.15252/Embj.2020106275 |
0.414 |
|
| 2020 |
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, et al. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. PMID 32726803 DOI: 10.1038/S41586-020-2601-5 |
0.346 |
|
| 2020 |
Armstrong Z, Kuo CL, Lahav D, Liu B, Johnson R, Beenakker TJM, de Boer C, Wong CS, van Rijssel ER, Debets MF, Florea BI, Hissink C, Boot RG, Geurink PP, Ovaa H, et al. Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. Journal of the American Chemical Society. PMID 32605368 DOI: 10.1021/Jacs.0C03880 |
0.396 |
|
| 2020 |
Schubert AF, Nguyen JV, Franklin TG, Geurink PP, Roberts CG, Sanderson DJ, Miller LN, Ovaa H, Hofmann K, Pruneda JN, Komander D. Identification and characterization of diverse OTU deubiquitinases in bacteria. The Embo Journal. e105127. PMID 32567101 DOI: 10.15252/Embj.2020105127 |
0.306 |
|
| 2020 |
Wössner N, Alhalabi Z, González J, Swyter S, Gan J, Schmidtkunz K, Zhang L, Vaquero A, Ovaa H, Einsle O, Sippl W, Jung M. Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD Dependent Lysine Deacetylases. Frontiers in Oncology. 10: 657. PMID 32426286 DOI: 10.3389/Fonc.2020.00657 |
0.36 |
|
| 2020 |
van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC, Filippov DV. Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. Chembiochem : a European Journal of Chemical Biology. PMID 32421893 DOI: 10.1002/Cbic.202000230 |
0.362 |
|
| 2020 |
van der Zanden SY, Luimstra JJ, Neefjes J, Borst J, Ovaa H. Opportunities for Small Molecules in Cancer Immunotherapy. Trends in Immunology. PMID 32381382 DOI: 10.1016/J.It.2020.04.004 |
0.312 |
|
| 2020 |
Wu HQ, Baker D, Ovaa H. Small molecules that target the ubiquitin system. Biochemical Society Transactions. PMID 32196552 DOI: 10.1042/Bst20190535 |
0.372 |
|
| 2020 |
van Kruijsbergen I, Mulder MPC, Uckelmann M, van Welsem T, de Widt J, Spanjaard A, Jacobs H, El Oualid F, Ovaa H, van Leeuwen F. Strategy for Development of Site-Specific Ubiquitin Antibodies. Frontiers in Chemistry. 8: 111. PMID 32154221 DOI: 10.3389/Fchem.2020.00111 |
0.37 |
|
| 2019 |
Gjonaj L, Sapmaz A, Flierman D, Janssen GMC, van Veelen PA, Ovaa H. Development of a DUB-selective fluorogenic substrate. Chemical Science. 10: 10290-10296. PMID 32110315 DOI: 10.1039/C9Sc02226K |
0.416 |
|
| 2019 |
Pérez Berrocal DA, Witting KF, Ovaa H, Mulder MPC. Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code. Frontiers in Chemistry. 7: 931. PMID 32039151 DOI: 10.3389/Fchem.2019.00931 |
0.344 |
|
| 2019 |
Shahul Hameed D, van Tilburg GBA, Merkx R, Flierman D, Wienk H, El Oualid F, Hofmann K, Boelens R, Ovaa H. Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1. Frontiers in Chemistry. 7: 921. PMID 32039147 DOI: 10.3389/Fchem.2019.00921 |
0.343 |
|
| 2019 |
Xin BT, Jin G, Fernandez DJ, Knobeloch KP, Geurink PP, Ovaa H. Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties. Organic & Biomolecular Chemistry. PMID 31710063 DOI: 10.1039/C9Ob02127B |
0.38 |
|
| 2019 |
Mulder MPC, Witting KF, Ovaa H. Cracking the Ubiquitin Code: The Ubiquitin Toolbox. Current Issues in Molecular Biology. 37: 1-20. PMID 31674341 DOI: 10.21775/Cimb.037.001 |
0.417 |
|
| 2019 |
Karpiyevich M, Adjalley S, Mol M, Ascher DB, Mason B, van der Heden van Noort GJ, Laman H, Ovaa H, Lee MCS, Artavanis-Tsakonas K. Nedd8 hydrolysis by UCH proteases in Plasmodium parasites. Plos Pathogens. 15: e1008086. PMID 31658303 DOI: 10.1371/Journal.Ppat.1008086 |
0.327 |
|
| 2019 |
Luimstra JJ, Franken KLMC, Garstka MA, Drijfhout JW, Neefjes J, Ovaa H. Production and Thermal Exchange of Conditional Peptide-MHC I Multimers. Current Protocols in Immunology. 126. PMID 31483102 DOI: 10.1002/Cpim.85 |
0.302 |
|
| 2019 |
Schipper-Krom S, Sanz AS, van Bodegraven EJ, Speijer D, Florea BI, Ovaa H, Reits EA. Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes. Frontiers in Molecular Biosciences. 6: 56. PMID 31482094 DOI: 10.3389/Fmolb.2019.00056 |
0.395 |
|
| 2019 |
Hameed DS, Sapmaz A, Burggraaff L, Amore A, Slingerland CJ, van Westen GJP, Ovaa H. Development of a Ubiquitin based probe for metalloprotease deubiquitinases. Angewandte Chemie (International Ed. in English). PMID 31381834 DOI: 10.1002/Anie.201906790 |
0.417 |
|
| 2019 |
Jia Y, Claessens LA, Vertegaal ACO, Ovaa H. Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs). Acs Chemical Biology. PMID 31361113 DOI: 10.1021/Acschembio.9B00402 |
0.454 |
|
| 2019 |
Narasimhan S, Scherpe S, Lucini Paioni A, van der Zwan J, Folkers GE, Ovaa H, Baldus M. DNP supported solid-state NMR of proteins inside Mammalian Cells. Angewandte Chemie (International Ed. in English). PMID 31233270 DOI: 10.1002/anie.201903246 |
0.338 |
|
| 2019 |
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, ... ... Ovaa H, et al. Rapid covalent-probe discovery by electrophile-fragment screening. Journal of the American Chemical Society. PMID 31060360 DOI: 10.1021/Jacs.9B02822 |
0.327 |
|
| 2019 |
Spits M, Janssen LJ, Voortman LM, Kooij R, Neefjes ACM, Ovaa H, Neefjes J. Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis. Journal of Cell Science. 132. PMID 30992344 DOI: 10.1242/Jcs.225524 |
0.31 |
|
| 2019 |
Gjonaj L, Sapmaz A, González-Prieto R, Vertegaal ACO, Flierman D, Ovaa H. USP7: combining tools towards selectivity. Chemical Communications (Cambridge, England). 55: 5075-5078. PMID 30972393 DOI: 10.1039/C9Cc00969H |
0.347 |
|
| 2019 |
Gan J, Leestemaker Y, Sapmaz A, Ovaa H. Highlighting the Proteasome: Using Fluorescence to Visualize Proteasome Activity and Distribution. Frontiers in Molecular Biosciences. 6: 14. PMID 30968028 DOI: 10.3389/Fmolb.2019.00014 |
0.393 |
|
| 2019 |
Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H. USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7. Nature Communications. 10: 1454. PMID 30926795 DOI: 10.1038/S41467-019-09437-X |
0.34 |
|
| 2019 |
van der Heden van Noort GJ, Gan J, Ovaa H. Synthetic ubiquitinated proteins meet the proteasome: Distinct roles of ubiquitin in a chain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926663 DOI: 10.1073/Pnas.1903405116 |
0.393 |
|
| 2019 |
Geurink PP, van der Heden van Noort GJ, Mulder MPC, Knaap RCM, Kikkert M, Ovaa H. Profiling DUBs and Ubl-specific proteases with activity-based probes. Methods in Enzymology. 618: 357-387. PMID 30850060 DOI: 10.1016/Bs.Mie.2018.12.037 |
0.441 |
|
| 2019 |
Mons E, Jansen IDC, Loboda J, van Doodewaerd BR, Hermans J, Verdoes M, van Boeckel CAA, van Veelen PA, Turk B, Turk D, Ovaa H. The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K. Journal of the American Chemical Society. 141: 3507-3514. PMID 30689386 DOI: 10.1021/Jacs.8B11027 |
0.329 |
|
| 2019 |
Kim RQ, Geurink PP, Mulder MPC, Fish A, Ekkebus R, El Oualid F, van Dijk WJ, van Dalen D, Ovaa H, van Ingen H, Sixma TK. Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity. Nature Communications. 10: 231. PMID 30651545 DOI: 10.1038/S41467-018-08231-5 |
0.409 |
|
| 2019 |
Heijkants R, Teunisse A, de Vries J, Ovaa H, Jochemsen A. Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms. Acs Chemical Biology. 14: 132-136. PMID 30525429 DOI: 10.1021/Acschembio.8B00292 |
0.345 |
|
| 2019 |
van der Heden van Noort GJ, Talavera Ormeño C, van Dalen D, Ovaa H. One-Step Chemical Synthesis of Native Met1-Linked Poly-Ubiquitin Chains. Chembiochem : a European Journal of Chemical Biology. 20: 62-65. PMID 30264452 DOI: 10.1002/Cbic.201800520 |
0.393 |
|
| 2019 |
van der Heden van Noort GJ, Ovaa H. How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling. Current Topics in Microbiology and Immunology. 420: 111-130. PMID 30178261 DOI: 10.1007/82_2018_134 |
0.438 |
|
| 2019 |
Narasimhan S, Scherpe S, Lucini Paioni A, van der Zwan J, Folkers GE, Ovaa H, Baldus M. Rücktitelbild: DNP‐Supported Solid‐State NMR Spectroscopy of Proteins Inside Mammalian Cells (Angew. Chem. 37/2019) Angewandte Chemie. 131: 13296-13296. DOI: 10.1002/Ange.201908849 |
0.31 |
|
| 2018 |
Hameed DS, Sapmaz A, Gjonaj L, Merkx R, Ovaa H. Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates. Chembiochem : a European Journal of Chemical Biology. 19: 2553-2557. PMID 30351505 DOI: 10.1002/Cbic.201800649 |
0.359 |
|
| 2018 |
van Tol BDM, Geurink PP, Ovaa H. A MALDI-TOF Approach to Ubiquitin Ligase Activity. Cell Chemical Biology. 25: 1053-1055. PMID 30241600 DOI: 10.1016/J.Chembiol.2018.09.002 |
0.352 |
|
| 2018 |
Witting K, van der Heden van Noort G, Kofoed C, Talavera Ormeno C, El Atmioui D, Mulder MPC, Ovaa H. Generation of the UFM1 toolkit for profiling UFM1-specific proteases and ligases. Angewandte Chemie (International Ed. in English). PMID 30188611 DOI: 10.1002/Anie.201809232 |
0.429 |
|
| 2018 |
Xin BT, van Tol BDM, Ovaa H, Geurink PP. Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation. Organic & Biomolecular Chemistry. PMID 30117511 DOI: 10.1039/C8Ob01627E |
0.372 |
|
| 2018 |
Mulder MPC, Merkx R, Witting K, Hameed D, El Atmioui D, Lelieveld L, Liebelt F, Neefjes J, Berlin I, Vertegaal A, Ovaa H. Total chemical synthesis of SUMO and SUMO ABPs to profile activity of SUMO-specific proteases. Angewandte Chemie (International Ed. in English). PMID 29771001 DOI: 10.1002/Anie.201803483 |
0.446 |
|
| 2018 |
Luimstra JJ, Garstka MA, Roex MCJ, Redeker A, Janssen GMC, van Veelen PA, Arens R, Falkenburg JHF, Neefjes J, Ovaa H. A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells. The Journal of Experimental Medicine. PMID 29666167 DOI: 10.1084/Jem.20180156 |
0.302 |
|
| 2018 |
Ovaa H, Vertegaal ACO. Probing ubiquitin and SUMO conjugation and deconjugation. Biochemical Society Transactions. 46: 423-436. PMID 29588386 DOI: 10.1042/Bst20170086 |
0.378 |
|
| 2018 |
Eifler K, Cuijpers SAG, Willemstein E, Raaijmakers JA, El Atmioui D, Ovaa H, Medema RH, Vertegaal ACO. SUMO targets the APC/C to regulate transition from metaphase to anaphase. Nature Communications. 9: 1119. PMID 29549242 DOI: 10.1038/S41467-018-03486-4 |
0.362 |
|
| 2018 |
Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K. A family of unconventional deubiquitinases with modular chain specificity determinants. Nature Communications. 9: 799. PMID 29476094 DOI: 10.1038/S41467-018-03148-5 |
0.383 |
|
| 2018 |
Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D. Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463763 DOI: 10.1073/Pnas.1710617115 |
0.321 |
|
| 2018 |
Zhang X, Smits AH, van Tilburg GB, Ovaa H, Huber W, Vermeulen M. Proteome-wide identification of ubiquitin interactions using UbIA-MS. Nature Protocols. 13: 530-550. PMID 29446774 DOI: 10.1038/Nprot.2017.147 |
0.333 |
|
| 2018 |
Oerlemans R, Berkers CR, Assaraf YG, Scheffer GL, Peters GJ, Verbrugge SE, Cloos J, Slootstra J, Meloen RH, Shoemaker RH, Dijkmans BAC, Scheper RJ, Ovaa H, Jansen G. Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide. Investigational New Drugs. PMID 29442210 DOI: 10.1007/S10637-018-0569-X |
0.323 |
|
| 2018 |
Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Scientific Reports. 8: 1405. PMID 29362455 DOI: 10.1038/S41598-018-19538-0 |
0.414 |
|
| 2017 |
Palmer AL, de Jong A, Leestemaker Y, Geurink PP, Wijdeven RH, Ovaa H, Dolan BP. Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29282303 DOI: 10.4049/Jimmunol.1700273 |
0.373 |
|
| 2017 |
Leestemaker Y, Ovaa H. Tools to investigate the ubiquitin proteasome system. Drug Discovery Today. Technologies. 26: 25-31. PMID 29249239 DOI: 10.1016/J.Ddtec.2017.11.006 |
0.395 |
|
| 2017 |
Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort G, Filippov DV. A General Approach Towards Triazole-linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angewandte Chemie (International Ed. in English). PMID 29215186 DOI: 10.1002/Anie.201710527 |
0.332 |
|
| 2017 |
van der Heden van Noort GJ, Kooij R, Elliott PR, Komander D, Ovaa H. Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer. Organic Letters. 19: 6490-6493. PMID 29172548 DOI: 10.1021/Acs.Orglett.7B03085 |
0.308 |
|
| 2017 |
Dohmen AJC, Qiao X, Duursma A, Wijdeven RH, Lieftink C, Hageman F, Morris B, Halonen P, Vens C, van den Brekel MWM, Ovaa H, Neefjes J, Zuur CL. Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity. Oncotarget. 8: 73925-73937. PMID 29088757 DOI: 10.18632/Oncotarget.18034 |
0.337 |
|
| 2017 |
Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, et al. A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Non-lysosomal Glucosylceramidase. Journal of the American Chemical Society. PMID 28937220 DOI: 10.1021/Jacs.7B07352 |
0.401 |
|
| 2017 |
Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, ... ... Ovaa H, et al. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. The Journal of Clinical Investigation. PMID 28846070 DOI: 10.1172/Jci90895 |
0.306 |
|
| 2017 |
de Jong A, Witting K, Kooij R, Flierman D, Ovaa H. Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents. Angewandte Chemie (International Ed. in English). PMID 28841265 DOI: 10.1002/Anie.201706738 |
0.441 |
|
| 2017 |
Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H. Proteasome Activation by Small Molecules. Cell Chemical Biology. PMID 28552582 DOI: 10.1016/J.Chembiol.2017.05.010 |
0.413 |
|
| 2017 |
Witting KF, Mulder MPC, Ovaa H. Advancing our understanding of ubiquitination using the Ub-Toolkit. Journal of Molecular Biology. PMID 28410891 DOI: 10.1016/J.Jmb.2017.04.002 |
0.432 |
|
| 2017 |
Chojnacki M, Mansour W, Hameed DS, Singh RK, El Oualid F, Rosenzweig R, Nakasone MA, Yu Z, Glaser F, Kay LE, Fushman D, Ovaa H, Glickman MH. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chemical Biology. PMID 28330605 DOI: 10.1016/J.Chembiol.2017.02.013 |
0.39 |
|
| 2017 |
Zhang S, Burns-Huang KE, Janssen GV, Li H, Ovaa H, Hedstrom L, Darwin KH. Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates. Mbio. 8. PMID 28223451 DOI: 10.1128/Mbio.00122-17 |
0.382 |
|
| 2017 |
Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M. An Interaction Landscape of Ubiquitin Signaling. Molecular Cell. PMID 28190767 DOI: 10.1016/J.Molcel.2017.01.004 |
0.345 |
|
| 2017 |
Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G. Structural basis of the specificity of USP18 toward ISG15. Nature Structural & Molecular Biology. PMID 28165509 DOI: 10.1038/Nsmb.3371 |
0.39 |
|
| 2017 |
Leestemaker Y, de Jong A, Ovaa H. Profiling the Activity of Deubiquitinating Enzymes Using Chemically Synthesized Ubiquitin-Based Probes. Methods in Molecular Biology (Clifton, N.J.). 1491: 113-130. PMID 27778285 DOI: 10.1007/978-1-4939-6439-0_9 |
0.404 |
|
| 2017 |
Hameed DS, Sapmaz A, Ovaa H. How Chemical Synthesis of Ubiquitin Conjugates Helps To Understand Ubiquitin Signal Transduction. Bioconjugate Chemistry. 28: 805-815. PMID 27077728 DOI: 10.1021/Acs.Bioconjchem.6B00140 |
0.379 |
|
| 2016 |
Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, ... ... Ovaa H, et al. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorganic & Medicinal Chemistry Letters. PMID 27780639 DOI: 10.1016/J.Bmcl.2016.10.036 |
0.335 |
|
| 2016 |
Mevissen TE, Kulathu Y, Mulder MP, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BD, Akutsu M, El Oualid F, Kawasaki M, Freund SM, Ovaa H, Komander D. Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature. PMID 27732584 DOI: 10.1038/Nature19836 |
0.426 |
|
| 2016 |
Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW, Schulman BA. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Cell. 166: 1198-1214.e24. PMID 27565346 DOI: 10.1016/J.Cell.2016.07.027 |
0.317 |
|
| 2016 |
Pruneda JN, Durkin CH, Geurink PP, Ovaa H, Santhanam B, Holden DW, Komander D. The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases. Molecular Cell. PMID 27425412 DOI: 10.1016/J.Molcel.2016.06.015 |
0.415 |
|
| 2016 |
Rosendahl Huber SK, Luimstra JJ, van Beek J, Hoppes R, Jacobi RH, Hendriks M, Kapteijn K, Ouwerkerk C, Rodenko B, Ovaa H, de Jonge J. Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance. Plos One. 11: e0156462. PMID 27333291 DOI: 10.1371/Journal.Pone.0156462 |
0.301 |
|
| 2016 |
van Tilburg GB, Elhebieshy AF, Ovaa H. Synthetic and semi-synthetic strategies to study ubiquitin signaling. Current Opinion in Structural Biology. 38: 92-101. PMID 27315041 DOI: 10.1016/J.Sbi.2016.05.022 |
0.388 |
|
| 2016 |
Békés M, van der Heden van Noort GJ, Ekkebus R, Ovaa H, Huang TT, Lima CD. Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease. Molecular Cell. 62: 572-585. PMID 27203180 DOI: 10.1016/J.Molcel.2016.04.016 |
0.354 |
|
| 2016 |
Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nature Chemical Biology. PMID 27182664 DOI: 10.1038/Nchembio.2084 |
0.392 |
|
| 2016 |
Flierman D, van der Heden van Noort GJ, Ekkebus R, Geurink PP, Mevissen TE, Hospenthal MK, Komander D, Ovaa H. Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chemical Biology. 23: 472-82. PMID 27066941 DOI: 10.1016/J.Chembiol.2016.03.009 |
0.436 |
|
| 2016 |
Geurink PP, van Tol BD, van Dalen D, Brundel PJ, Mevissen TE, Pruneda JN, Elliott PR, van Tilburg GB, Komander D, Ovaa H. Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes. Chembiochem : a European Journal of Chemical Biology. PMID 26996281 DOI: 10.1002/Cbic.201600017 |
0.402 |
|
| 2016 |
Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, et al. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. PMID 26930717 DOI: 10.18632/Oncotarget.7596 |
0.327 |
|
| 2016 |
Sahtoe DD, van Dijk WJ, Ekkebus R, Ovaa H, Sixma TK. BAP1/ASXL1 recruitment and activation for H2A deubiquitination. Nature Communications. 7: 10292. PMID 26739236 DOI: 10.1038/Ncomms10292 |
0.327 |
|
| 2016 |
Bekes M, Ekkebus R, Noort GJvdHv, Ovaa H, Huang TT, Lima CD. Structural basis for the diUb-Lys48 recognition and specificity of the SARS coronavirus deubiquitinating enzyme, SARS PLpro Molecular Cell. 62. DOI: 10.2210/Pdb5E6J/Pdb |
0.325 |
|
| 2015 |
Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N. De-ubiquitylase inhibition reveals LXR-independent transcriptional regulation of the E3 ubiquitin ligase IDOL and lipoprotein uptake. The Journal of Biological Chemistry. PMID 26719329 DOI: 10.1074/Jbc.M115.698688 |
0.339 |
|
| 2015 |
Leestemaker Y, Ovaa H. Hitting the target. Nature Methods. 12: 1127-8. PMID 26624797 DOI: 10.1038/Nmeth.3660 |
0.312 |
|
| 2015 |
Navarro-Yepes J, Anandhan A, Bradley E, Bohovych I, Yarabe B, de Jong A, Ovaa H, Zhou Y, Khalimonchuk O, Quintanilla-Vega B, Franco R. Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways. Molecular Neurobiology. PMID 26409479 DOI: 10.1007/S12035-015-9414-9 |
0.351 |
|
| 2014 |
Ekkebus R, Flierman D, Geurink PP, Ovaa H. Catching a DUB in the act: novel ubiquitin-based active site directed probes. Current Opinion in Chemical Biology. 23: 63-70. PMID 25461387 DOI: 10.1016/J.Cbpa.2014.10.005 |
0.412 |
|
| 2014 |
Wijdeven RH, Neefjes J, Ovaa H. How chemistry supports cell biology: The chemical toolbox at your service Trends in Cell Biology. 24: 751-760. DOI: 10.1016/J.Tcb.2014.07.002 |
0.329 |
|
| 2013 |
Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, et al. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nature Communications. 4: 2656. PMID 24141283 DOI: 10.1038/Ncomms3656 |
0.366 |
|
| 2013 |
Smit JJ, van Dijk WJ, El Atmioui D, Merkx R, Ovaa H, Sixma TK. Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements. The Journal of Biological Chemistry. 288: 31728-37. PMID 24030825 DOI: 10.1074/Jbc.M113.495846 |
0.353 |
|
| 2013 |
van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity. 39: 259-71. PMID 23973222 DOI: 10.1016/J.Immuni.2013.05.018 |
0.332 |
|
| 2013 |
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 154: 169-84. PMID 23827681 DOI: 10.1016/J.Cell.2013.05.046 |
0.361 |
|
| 2013 |
Orre M, Kamphuis W, Dooves S, Kooijman L, Chan ET, Kirk CJ, Dimayuga Smith V, Koot S, Mamber C, Jansen AH, Ovaa H, Hol EM. Reactive glia show increased immunoproteasome activity in Alzheimer's disease. Brain : a Journal of Neurology. 136: 1415-31. PMID 23604491 DOI: 10.1093/Brain/Awt083 |
0.355 |
|
| 2013 |
Ekkebus R, van Kasteren SI, Kulathu Y, Scholten A, Berlin I, Geurink PP, de Jong A, Goerdayal S, Neefjes J, Heck AJ, Komander D, Ovaa H. On terminal alkynes that can react with active-site cysteine nucleophiles in proteases. Journal of the American Chemical Society. 135: 2867-70. PMID 23387960 DOI: 10.1021/Ja309802N |
0.387 |
|
| 2013 |
Bai Z, Cai L, Umemoto E, Takeda A, Tohya K, Komai Y, Veeraveedu PT, Hata E, Sugiura Y, Kubo A, Suematsu M, Hayasaka H, Okudaira S, Aoki J, Tanaka T, ... ... Ovaa H, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. Journal of Immunology (Baltimore, Md. : 1950). 190: 2036-48. PMID 23365076 DOI: 10.4049/Jimmunol.1202025 |
0.31 |
|
| 2013 |
Amore A, Wals K, Koekoek E, Hoppes R, Toebes M, Schumacher TNM, Rodenko B, Ovaa H. Development of a Hypersensitive Periodate‐Cleavable Amino Acid that is Methionine‐ and Disulfide‐Compatible and its Application in MHC Exchange Reagents for T Cell Characterisation Chembiochem. 14: 123-131. PMID 23280887 DOI: 10.1002/Cbic.201200540 |
0.304 |
|
| 2013 |
Hoppes R, Lokhorst H, Spaapen RM, Ovaa H, Mutis T. Improved Vaccine Design For Adoptive Immunotherapy In Hematological Malignancies Through Chemically Modified Minor Histocompatibility Antigen Epitopes Blood. 122: 5435-5435. DOI: 10.1182/Blood.V122.21.5435.5435 |
0.316 |
|
| 2012 |
de Jong A, Merkx R, Berlin I, Rodenko B, Wijdeven RH, El Atmioui D, Yalçin Z, Robson CN, Neefjes JJ, Ovaa H. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. Chembiochem : a European Journal of Chemical Biology. 13: 2251-8. PMID 23011887 DOI: 10.1002/Cbic.201200497 |
0.406 |
|
| 2012 |
Burns KE, McAllister FE, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH. Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase. The Journal of Biological Chemistry. 287: 37522-9. PMID 22942282 DOI: 10.1074/Jbc.M112.384784 |
0.42 |
|
| 2012 |
Merkx R, Burns KE, Slobbe P, El Oualid F, El Atmioui D, Darwin KH, Ovaa H. Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis. Chembiochem : a European Journal of Chemical Biology. 13: 2056-60. PMID 22927162 DOI: 10.1002/Cbic.201200460 |
0.354 |
|
| 2012 |
Schulz S, Chachami G, Kozaczkiewicz L, Winter U, Stankovic-Valentin N, Haas P, Hofmann K, Urlaub H, Ovaa H, Wittbrodt J, Meulmeester E, Melchior F. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. Embo Reports. 13: 930-8. PMID 22878415 DOI: 10.1038/Embor.2012.125 |
0.424 |
|
| 2012 |
Berkers CR, Leestemaker Y, Schuurman KG, Ruggeri B, Jones-Bolin S, Williams M, Ovaa H. Probing the specificity and activity profiles of the proteasome inhibitors bortezomib and delanzomib. Molecular Pharmaceutics. 9: 1126-1135. PMID 22432738 DOI: 10.1021/Mp2004143 |
0.412 |
|
| 2012 |
Albers HM, Ovaa H. Chemical evolution of autotaxin inhibitors. Chemical Reviews. 112: 2593-603. PMID 22335786 DOI: 10.1021/Cr2003213 |
0.32 |
|
| 2012 |
Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nature Structural & Molecular Biology. 19: 62-71. PMID 22157957 DOI: 10.1038/Nsmb.2169 |
0.338 |
|
| 2012 |
Jong Ad, Schuurman KG, Rodenko B, Ovaa H, Berkers CR. Fluorescence-based proteasome activity profiling. Methods of Molecular Biology. 803: 183-204. PMID 22065226 DOI: 10.1007/978-1-61779-364-6_13 |
0.356 |
|
| 2012 |
Wijdeven R, Berlin I, Ovaa H, Neefjes J. Finding inhibitors for de-ubiquitinating enzymes (DUBs) that regulate MHCII transcription Molecular Immunology. 51: 36. DOI: 10.1016/J.Molimm.2012.02.104 |
0.356 |
|
| 2011 |
Geurink PP, El Oualid F, Jonker A, Hameed DS, Ovaa H. A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents. Chembiochem : a European Journal of Chemical Biology. 13: 293-7. PMID 22213387 DOI: 10.1002/Cbic.201100706 |
0.405 |
|
| 2011 |
Faesen AC, Luna-Vargas MP, Geurink PP, Clerici M, Merkx R, van Dijk WJ, Hameed DS, El Oualid F, Ovaa H, Sixma TK. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chemistry & Biology. 18: 1550-61. PMID 22195557 DOI: 10.1016/J.Chembiol.2011.10.017 |
0.319 |
|
| 2011 |
Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A, Sixma TK. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Molecular Cell. 44: 147-59. PMID 21981925 DOI: 10.1016/J.Molcel.2011.06.034 |
0.342 |
|
| 2011 |
van Kasteren SI, Berlin I, Colbert JD, Keane D, Ovaa H, Watts C. A multifunctional protease inhibitor to regulate endolysosomal function. Acs Chemical Biology. 6: 1198-204. PMID 21910425 DOI: 10.1021/Cb200292C |
0.411 |
|
| 2011 |
Albers HM, Hendrickx LJ, van Tol RJ, Hausmann J, Perrakis A, Ovaa H. Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of Medicinal Chemistry. 54: 4619-26. PMID 21615078 DOI: 10.1021/Jm200310Q |
0.35 |
|
| 2011 |
Nijholt DAT, Graaf TRd, Haastert ESv, Oliveira AO, Berkers CR, Zwart R, Ovaa H, Baas F, Hoozemans JJM, Scheper W. Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease Cell Death & Differentiation. 18: 1071-1081. PMID 21252911 DOI: 10.1038/Cdd.2010.176 |
0.313 |
|
| 2011 |
Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, ... ... Ovaa H, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Current Cancer Drug Targets. 11: 254-84. PMID 21247382 DOI: 10.2174/156800911794519716 |
0.339 |
|
| 2011 |
Frederiks F, Stulemeijer IJE, Ovaa H, Leeuwen Fv. A modified epigenetics toolbox to study histone modifications on the nucleosome core. Chembiochem. 12: 308-313. PMID 21243718 DOI: 10.1002/Cbic.201000617 |
0.307 |
|
| 2011 |
Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, ... ... Ovaa H, et al. Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology. 18: 198-204. PMID 21240271 DOI: 10.1038/Nsmb.1980 |
0.382 |
|
| 2010 |
El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin. Angewandte Chemie (International Ed. in English). 49: 10149-53. PMID 21117055 DOI: 10.1002/Anie.201005995 |
0.367 |
|
| 2010 |
Cavalli S, Houben AJ, Albers HM, van Tilburg EW, de Ru A, Aoki J, van Veelen P, Moolenaar WH, Ovaa H. Development of an activity-based probe for autotaxin. Chembiochem : a European Journal of Chemical Biology. 11: 2311-7. PMID 20941725 DOI: 10.1002/Cbic.201000349 |
0.382 |
|
| 2010 |
Hoppes R, Ekkebus R, Schumacher TNM, Ovaa H. Technologies for MHC class I immunoproteomics. Journal of Proteomics. 73: 1945-1953. PMID 20546957 DOI: 10.1016/J.Jprot.2010.05.009 |
0.31 |
|
| 2010 |
Shanmugham A, Fish A, Luna-Vargas MP, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes. Journal of the American Chemical Society. 132: 8834-5. PMID 20540574 DOI: 10.1021/Ja101803S |
0.382 |
|
| 2010 |
Albers HM, van Meeteren LA, Egan DA, van Tilburg EW, Moolenaar WH, Ovaa H. Discovery and optimization of boronic acid based inhibitors of autotaxin. Journal of Medicinal Chemistry. 53: 4958-67. PMID 20536182 DOI: 10.1021/Jm1005012 |
0.359 |
|
| 2010 |
Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proceedings of the National Academy of Sciences of the United States of America. 107: 7257-62. PMID 20360563 DOI: 10.1073/Pnas.1001529107 |
0.363 |
|
| 2010 |
Berkers CR, Ovaa H. Drug discovery and assay development in the ubiquitin–proteasome system Biochemical Society Transactions. 38: 14-20. PMID 20074028 DOI: 10.1042/Bst0380014 |
0.33 |
|
| 2010 |
Verzijlbergen KF, Menendez-Benito V, van Welsem T, van Deventer SJ, Lindstrom DL, Ovaa H, Neefjes J, Gottschling DE, van Leeuwen F. Recombination-induced tag exchange to track old and new proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 64-8. PMID 20018668 DOI: 10.1073/Pnas.0911164107 |
0.327 |
|
| 2010 |
Cavalli S, Houben AJS, Albers HMHG, van Tilburg EW, de Ru A, Aoki J, van Veelen P, Moolenaar WH, Ovaa H. Cover Picture: Development of an Activity-Based Probe for Autotaxin (ChemBioChem 16/2010) Chembiochem. 11: 2193-2193. DOI: 10.1002/Cbic.201090077 |
0.304 |
|
| 2009 |
Hadrup SR, Toebes M, Rodenko B, Bakker AH, Egan DA, Ovaa H, Schumacher TN. High-throughput T-cell epitope discovery through MHC peptide exchange. Methods in Molecular Biology (Clifton, N.J.). 524: 383-405. PMID 19377960 DOI: 10.1007/978-1-59745-450-6_28 |
0.314 |
|
| 2009 |
Middeldorp J, Kamphuis W, Sluijs JA, Achoui D, Leenaars CH, Feenstra MG, van Tijn P, Fischer DF, Berkers C, Ovaa H, Quinlan RA, Hol EM. Intermediate filament transcription in astrocytes is repressed by proteasome inhibition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2710-26. PMID 19332645 DOI: 10.1096/Fj.08-127696 |
0.355 |
|
| 2009 |
Crawford LJ, Windrum P, Magill L, Melo JV, McCallum L, McMullin MF, Ovaa H, Walker B, Irvine AE. Proteasome proteolytic profile is linked to Bcr-Abl expression. Experimental Hematology. 37: 357-66. PMID 19157685 DOI: 10.1016/J.Exphem.2008.11.004 |
0.39 |
|
| 2008 |
Shanmugham A, Ovaa H. DUBs and disease: activity assays for inhibitor development. Current Opinion in Drug Discovery & Development. 11: 688-96. PMID 18729020 |
0.307 |
|
| 2008 |
Raijmakers R, Berkers CR, de Jong A, Ovaa H, Heck AJ, Mohammed S. Automated online sequential isotope labeling for protein quantitation applied to proteasome tissue-specific diversity. Molecular & Cellular Proteomics : McP. 7: 1755-62. PMID 18534969 DOI: 10.1074/Mcp.M800093-Mcp200 |
0.331 |
|
| 2008 |
Birks EJ, Latif N, Enesa K, Folkvang T, Luong LA, Sarathchandra P, Khan M, Ovaa H, Terracciano CM, Barton PJR, Yacoub MH, Evans PC. Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy Cardiovascular Research. 79: 472-480. PMID 18375498 DOI: 10.1093/Cvr/Cvn083 |
0.305 |
|
| 2008 |
Piva R, Ruggeri B, Williams M, Costa G, Tamagno I, Ferrero D, Giai V, Coscia M, Peola S, Massaia M, Pezzoni G, Allievi C, Pescalli N, Cassin M, di Giovine S, ... ... Ovaa H, et al. CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood. 111: 2765-75. PMID 18057228 DOI: 10.1182/Blood-2007-07-100651 |
0.37 |
|
| 2008 |
Crawford L, Windrum P, Magill L, Melo JV, McCallum L, McMullin M, Ovaa H, Walker B, Irvine A. Bcr-Abl Positive Cells Display Increased Proteasome Activity and Greater Sensitivity to Proteasome Inhibition Blood. 112: 3192-3192. DOI: 10.1182/Blood.V112.11.3192.3192 |
0.361 |
|
| 2007 |
Butterworth MB, Edinger RS, Ovaa H, Burg D, Johnson JP, Frizzell RA. The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. The Journal of Biological Chemistry. 282: 37885-93. PMID 17967898 DOI: 10.1074/Jbc.M707989200 |
0.325 |
|
| 2007 |
Berkers CR, van Leeuwen FW, Groothuis TA, Peperzak V, van Tilburg EW, Borst J, Neefjes JJ, Ovaa H. Profiling proteasome activity in tissue with fluorescent probes. Molecular Pharmaceutics. 4: 739-48. PMID 17708652 DOI: 10.1021/Mp0700256 |
0.371 |
|
| 2007 |
Ovaa H. Active-site directed probes to report enzymatic action in the ubiquitin proteasome system Nature Reviews Cancer. 7: 613-620. PMID 17646866 DOI: 10.1038/Nrc2128 |
0.392 |
|
| 2007 |
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menéndez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ. Disease-associated prion protein oligomers inhibit the 26S proteasome. Molecular Cell. 26: 175-88. PMID 17466621 DOI: 10.1016/J.Molcel.2007.04.001 |
0.357 |
|
| 2007 |
Ponnappan S, Ovaa H, Ponnappan U. Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging. The International Journal of Biochemistry & Cell Biology. 39: 799-809. PMID 17317272 DOI: 10.1016/J.Biocel.2007.01.002 |
0.405 |
|
| 2007 |
Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, Ovaa H, Tatsumi K, Komatsu M, Tanaka K, Chung CH. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. The Journal of Biological Chemistry. 282: 5256-62. PMID 17182609 DOI: 10.1074/Jbc.M610590200 |
0.399 |
|
| 2006 |
Verdoes M, Florea BI, Menendez-Benito V, Maynard CJ, Witte MD, van der Linden WA, van den Nieuwendijk AM, Hofmann T, Berkers CR, van Leeuwen FW, Groothuis TA, Leeuwenburgh MA, Ovaa H, Neefjes JJ, Filippov DV, et al. A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chemistry & Biology. 13: 1217-26. PMID 17114003 DOI: 10.1016/J.Chembiol.2006.09.013 |
0.419 |
|
| 2006 |
Hol EM, Fischer DF, Ovaa H, Scheper W. Ubiquitin proteasome system as a pharmacological target in neurodegeneration. Expert Review of Neurotherapeutics. 6: 1337-47. PMID 17009921 DOI: 10.1586/14737175.6.9.1337 |
0.31 |
|
| 2006 |
Verdoes M, Berkers CR, Florea BI, Swieten PFv, Overkleeft HS, Ovaa H. Chemical proteomics profiling of proteasome activity. Methods of Molecular Biology. 328: 51-69. PMID 16785641 DOI: 10.1385/1-59745-026-X:51 |
0.41 |
|
| 2006 |
Crawford LJA, Walker B, Ovaa H, Chauhan D, Anderson KC, Morris TCM, Irvine AE. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Research. 66: 6379-6386. PMID 16778216 DOI: 10.1158/0008-5472.Can-06-0605 |
0.413 |
|
| 2006 |
Groll M, Berkers CR, Ploegh HL, Ovaa H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome Structure. 14: 451-456. PMID 16531229 DOI: 10.1016/J.Str.2005.11.019 |
0.335 |
|
| 2006 |
Chauhan D, Singh A, Velankar M, Hideshima T, Ovaa H, Berkers C, Bianchi G, Sitia R, Munshi NC, Richardson P, Palladino MA, Anderson KC. Distinct Dynamic Profiles for NPI-0052-And Bortezomib-Induced Apoptosis in Multiple Myeloma. Blood. 108: 3396-3396. DOI: 10.1182/Blood.V108.11.3396.3396 |
0.337 |
|
| 2005 |
Ovaa H, Galardy PJ, Ploegh HL. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Synthesis of active site-directed probes Methods in Enzymology. 399: 468-478. PMID 16338376 DOI: 10.1016/S0076-6879(05)99032-0 |
0.464 |
|
| 2005 |
Galardy P, Ploegh HL, Ovaa H. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Crystallography, activity profiling, and protease identification Methods in Enzymology. 399: 120-131. PMID 16338352 DOI: 10.1016/S0076-6879(05)99008-3 |
0.448 |
|
| 2005 |
Chauhan D, Catley L, Li G, Podar K, Hideshima T, Velankar M, Mitsiades C, Mitsiades N, Yasui H, Letai A, Ovaa H, Berkers C, Nicholson B, Chao TH, Neuteboom ST, et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell. 8: 407-19. PMID 16286248 DOI: 10.1016/J.Ccr.2005.10.013 |
0.327 |
|
| 2005 |
Meulmeester E, Maurice MM, Boutell C, Teunisse AFAS, Ovaa H, Abraham TE, Dirks RW, Jochemsen AG. Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 Molecular Cell. 18: 565-576. PMID 15916963 DOI: 10.1016/J.Molcel.2005.04.024 |
0.344 |
|
| 2005 |
Berkers CR, Ovaa H. Immunotherapeutic potential for ceramide-based activators of iNKT cells Trends in Pharmacological Sciences. 26: 252-257. PMID 15860372 DOI: 10.1016/J.Tips.2005.03.005 |
0.316 |
|
| 2005 |
Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib Nature Methods. 2: 357-362. PMID 15846363 DOI: 10.1038/Nmeth759 |
0.39 |
|
| 2005 |
Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/Cbic.200400236 |
0.397 |
|
| 2005 |
Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of Biological Chemistry. 280: 1512-20. PMID 15531586 DOI: 10.1074/Jbc.M410770200 |
0.385 |
|
| 2005 |
Driessen C, Kraus M, Gogel J, Beck A, Kammer W, Ovaa H, Overkleeft H, Rückrich T. Activity Profiling of Proteasome Subunits and Deubiquitinating Enzymes in Human Hematopoetic Malignancies. Blood. 106: 617-617. DOI: 10.1182/Blood.V106.11.617.617 |
0.376 |
|
| 2005 |
Driessen C, Gogel J, Kraus M, Ovaa H, Beck A, Rückrich T. Acquired Bortezomib (Velcade®)-Resistance Is Accompanied by Downmodulation of Proteasome Activity and Upregulation of Tripeptidyl Peptidase II (TPPII) and a Ubiquitin-Specific Protease. Blood. 106: 3375-3375. DOI: 10.1182/Blood.V106.11.3375.3375 |
0.371 |
|
| 2005 |
Crawford LJA, Ovaa H, Walker B, Chauhan D, Anderson KC, Morris TCM, Irvine AE. Evaluation of the Specificity and Cytotoxicity of Three Proteasome Inhibitors. Blood. 106: 3366-3366. DOI: 10.1182/Blood.V106.11.3366.3366 |
0.373 |
|
| 2005 |
Chauhan D, Chao T, Catley L, Nicholson B, Velanker M, Hideshima T, Berkers C, Ovaa H, Neuteboom S, Palladino M, Anderson KC. In vitro and in vivo proteasome activity profiles of bortezomib and a novel proteasome inhibitor NPI-0052 Blood. 106: 3363-3363. DOI: 10.1182/Blood.V106.11.3363.3363 |
0.317 |
|
| 2004 |
Bogyo M, Baruch A, Jeffery DA, Greenbaum D, Borodovsky A, Ovaa H, Kessler B. Applications for chemical probes of proteolytic activity. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.17. PMID 18429259 DOI: 10.1002/0471140864.Ps2117S36 |
0.416 |
|
| 2004 |
Hemelaar J, Galardy PJ, Borodovsky A, Kessler BM, Ploegh HL, Ovaa H. Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. Journal of Proteome Research. 3: 268-76. PMID 15113103 DOI: 10.1021/Pr0341080 |
0.408 |
|
| 2004 |
Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Proceedings of the National Academy of Sciences of the United States of America. 101: 4566-4571. PMID 15070758 DOI: 10.1073/Pnas.0400885101 |
0.304 |
|
| 2004 |
Ovaa H, Kessler BM, Rolén U, Galardy PJ, Ploegh HL, Masucci MG. Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 2253-8. PMID 14982996 DOI: 10.1073/Pnas.0308411100 |
0.358 |
|
| 2004 |
Evans PC, Ovaa H, Hamon M, Kilshaw PJ, Hamm S, Bauer S, Ploegh HL, Smith TS. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. The Biochemical Journal. 378: 727-34. PMID 14748687 DOI: 10.1042/Bj20031377 |
0.417 |
|
| 2004 |
Hemelaar J, Borodovsky A, Kessler BM, Reverter D, Cook J, Kolli N, Gan-Erdene T, Wilkinson KD, Gill G, Lima CD, Ploegh HL, Ovaa H. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Molecular and Cellular Biology. 24: 84-95. PMID 14673145 DOI: 10.1128/Mcb.24.1.84-95.2004 |
0.454 |
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| 2003 |
Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angewandte Chemie (International Ed. in English). 42: 3626-9. PMID 12916032 DOI: 10.1002/Anie.200351314 |
0.333 |
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| 2002 |
Borodovsky A, Ovaa H, Kolli N, Gan-Erdene T, Wilkinson KD, Ploegh HL, Kessler BM. Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chemistry & Biology. 9: 1149-59. PMID 12401499 DOI: 10.1016/S1074-5521(02)00248-X |
0.418 |
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